Sterile isolation medicine mixing device for pharmacy
By designing an automated unpacking and feeding mechanism and a tilting component, the problem of manual labor dependence in the isolation mixing device was solved, achieving uniform mixing and efficient stirring of solid and liquid materials, and improving the quality consistency of the mixed drug product.
Patent Information
- Application Number
- CN202511911498.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-17
- Publication Date
- 2026-02-24
AI Technical Summary
Existing drug mixing devices rely heavily on manual labor, have low efficiency, and solid materials tend to clump together during solid-liquid mixing, affecting the consistency of the finished drug product's quality.
A sterile isolation mixing device was designed, which includes an unpacking and feeding mechanism and a tilting component. The device uses components such as a lifting electric cylinder, a tilting motor and an air needle to realize the automated unpacking and feeding of solid raw materials. The uniform falling and mixing of materials is achieved by a cloth-spreading motor and a diversion water drain, avoiding the difficulty of manual operation and material waste.
It improves the automation level of the equipment, increases the efficiency of mixing, ensures full utilization and uniform mixing of materials, and reduces material waste and operational errors.
Smart Images
Figure CN121550894A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of mixing equipment technology, and in particular to a sterile, isolated mixing device for pharmaceuticals. Background Technology
[0002] In fields such as biopharmaceuticals, fine chemicals, and specialty formulations, where strict isolation and sterility requirements exist for material mixing environments, it is crucial to prevent these materials from deteriorating or becoming contaminated upon contact with the external environment. Furthermore, to prevent leakage and potential health threats to operators, the unpacking, loading, and subsequent mixing of these materials must be completed within sealed isolation boxes (glove boxes) or other isolated spaces. This establishes an independent isolation and protection system, ensuring the purity and activity of the materials and the safety of the operational process.
[0003] Since the unpacking and loading of solid raw materials largely rely on manual operation through the glove box opening, the limited movement of gloves makes unpacking difficult and inefficient. This not only limits the automation level of the overall drug mixing process but also makes it easy for materials to spill or become contaminated due to human error. Furthermore, materials are prone to remain inside the bags, making it difficult to unload completely and resulting in material waste. In the solid-liquid mixing stage, solid materials are very easy to clump together when poured directly, making it difficult to ensure the consistency of the final mixed drug product's quality even with manual stirring assistance. Summary of the Invention
[0004] This invention provides a sterile isolation mixing device for pharmaceuticals, which can solve the problems of high dependence on manual labor and low working efficiency in existing isolation mixing devices.
[0005] The present invention provides a sterile isolation mixing device for pharmaceuticals, including a glove box, wherein the inside of the glove box is provided with a packaging unpacking and feeding mechanism, the packaging unpacking and feeding mechanism including a material transfer and unpacking component for unpacking raw materials and a tilting component for flipping and tilting the packaging. The material transfer and unpacking assembly includes a material transfer guide rail, a lifting electric cylinder is slidably installed on the inner wall of the material transfer guide rail, a cutting unit is fixedly connected to the output end of the lifting electric cylinder, the cutting unit includes a cutting frame, a cutting cavity is opened in the middle of the cutting frame, a pressing roller is rotatably installed on the top of the inner side wall of the cutting cavity, a pushing electric cylinder is fixedly installed on the bottom of the inner side wall of the cutting cavity, a cutting blade is fixedly connected to the output end of the pushing electric cylinder, a material picking clamp is fixedly installed below the cutting frame, and a mixing hopper is fixedly installed on the bottom of the inner wall of the glove box, with a discharge pipe connected to the bottom of the mixing hopper.
[0006] As a further aspect of the present invention: the tilting assembly includes a tilting motor, the output end of which is fixedly connected to a tilting disc, a bag bottom limiting unit is fixedly connected to one side of the tilting disc, the bag bottom limiting unit includes a support frame, clamping frames are fixedly installed on both sides of the support frame, clamping electric cylinders are fixedly installed inside the two clamping frames, and clamping plates are fixedly connected to the output ends of the two clamping electric cylinders.
[0007] As a further aspect of the present invention: a plurality of clamping cones are fixedly connected to the middle of the two clamping plates, and air needles are fixedly installed in the middle of the plurality of clamping cones. One end of the plurality of air needles is connected to an air inlet pipe, and an air pump is fixedly installed in one end of the air inlet pipe.
[0008] As a further aspect of the present invention: a dispersing and distributing device is provided above the mixing hopper, the dispersing and distributing device includes a distributing frame, a material dividing screen is fixedly connected to the bottom of the distributing frame, a distributing motor is fixedly installed in the middle of the material dividing screen, a distributing trough is fixedly connected to the output end of the distributing motor, an opening is provided at the bottom of the distributing trough, the bottom of the opening is in close contact with the top of the material dividing screen, and the area of the material dividing screen is smaller than the top area of the mixing hopper.
[0009] As a further aspect of the present invention: a top cover plate is fixedly connected to the top of the fabric rack, a feeding port is opened on the top of the top cover plate, a weighing hopper is provided on the top of the feeding port, and a quantitative controller is provided inside the weighing hopper.
[0010] As a further aspect of the present invention: a receiving baffle is fixedly connected to the top of the weighing hopper, and the edge of the receiving baffle is bent upward; feed baffles are fixedly connected to both sides of the inner wall of the weighing hopper, and the two feed baffles are inclined downward toward the side that is closer to each other.
[0011] As a further embodiment of the present invention: a feeding box is fixedly installed on one side of the glove box, a through groove is provided at the connection between the feeding box and the glove box, a flexible baffle is fixed on the inner wall of the through groove, a conveyor frame is fixedly installed inside the feeding box, a feeding conveyor belt is rotatably installed on the inner wall of the conveyor frame, and a number of limiting baffles are fixedly connected to the surface of the feeding conveyor belt.
[0012] As a further embodiment of the present invention: discharge rollers are rotatably connected to one side edge of both clamping frames, a discharge groove is provided at the bottom of the support frame, a discharge port is provided on one side of the receiving baffle, the top of the discharge port is correspondingly arranged to the top of the discharge groove, a guide tube is fixedly connected to the bottom of the discharge port, a plurality of guide rollers are rotatably connected to the inner wall of the guide tube, one end of the guide tube is inclined downward, and a storage box is fixedly connected to one end of the guide tube.
[0013] As a further aspect of the present invention: a solution pipe is fixedly connected to one side of the stirring hopper, a plurality of diversion water drains are fixedly connected to the inner wall of the stirring hopper, a connecting pipe is fixedly connected to the middle of each of the plurality of diversion water drains, the plurality of connecting pipes are connected to the solution pipe, a plurality of diversion ports are opened on one side of each of the plurality of diversion water drains, the other side of each of the plurality of diversion water drains is set as an inclined surface, and a stirrer is provided inside the stirring hopper.
[0014] As a further embodiment of the present invention: an installation platform is fixedly connected to the bottom of the inner wall of the mixing hopper, and a discharge chute for material to pass through is opened on the edge of the installation platform. A discharge electric cylinder is fixedly installed below the installation platform, and a sealing plug is fixedly connected to the output end of the discharge electric cylinder. The top of the sealing plug is correspondingly arranged with the discharge chute, and the agitator is fixedly installed on the installation platform.
[0015] Compared with the prior art, the beneficial effects of the present invention are: the isolation mixing device of the present invention, by setting up a packaging and feeding mechanism, automatically completes the packaging and feeding operations of solid raw materials inside the glove box, avoiding the problems of high operation difficulty and slow packaging speed caused by manual packaging operation using the glove box, thus improving the automation level of the device and improving the mixing efficiency. This invention utilizes a cutting unit and a pusher cylinder to move the cutting blade, opening the packaging bag. A clamping plate then clamps and transfers the bag after the opening is cut, moving the material to the loading position. A bottom-supporting unit supports the bag from the bottom, reducing stress fluctuations on the clamping plate and stabilizing the bag's orientation for stable tilting and unloading. A clamping cylinder moves the clamping plate, ensuring stable clamping and limiting of bags of different sizes, improving stability during tilting and movement. Simultaneously, a needle piercing the bag blows air into it, effectively expelling any remaining material and maximizing material utilization.
[0016] This invention utilizes a feeding motor to drive the feeding trough to rotate, causing the material to fall periodically and evenly through the distribution mesh, achieving uniform distribution of the falling material in the direction of the mixing hopper. This effectively prevents the material from clumping together, thus ensuring stable and uneven mixing. Liquid material is delivered through dispersed drainage channels and outlets, circulating along the inner wall of the mixing hopper. This effectively catches the falling solid material, achieving uniform mixing through continuous flow, preventing solid material from agglomerating, and also preventing adhesion to the inner walls of other mixing hoppers, further improving mixing uniformity. Attached Figure Description
[0017] Figure 1 This is a three-dimensional schematic diagram of the present invention; Figure 2 This is a schematic diagram of the internal structure of the present invention; Figure 3 This is a frontal cross-sectional view of the present invention. Figure 4 This is a schematic diagram of the flip component structure of the present invention; Figure 5 This is a schematic diagram of the structure of the notch unit of the present invention; Figure 6 This is a three-dimensional schematic diagram of the bag bottom limiting unit of the present invention; Figure 7 This is a cross-sectional schematic diagram of the bag bottom limiting unit of the present invention; Figure 8 This is a schematic diagram of the structure of the mixing hopper of the present invention.
[0018] Explanation of reference numerals in the attached figures: 1. Glove box; 2. Feeding box; 3. Mixing hopper; 301. Diverting drain; 302. Diverting outlet; 303. Mounting platform; 304. Agitator; 4. Discharge pipe; 5. Material transfer guide rail; 6. Lifting cylinder; 7. Solution pipe; 8. Material distribution rack; 9. Material distribution trough; 10. Material distribution mesh; 11. Weighing hopper; 12. Feed baffle; 13. Receiving baffle; 14. Feeding conveyor belt; 15. Tilting plate; 16. Bag bottom limiting unit; 1601. Support frame; 1602. Clamping frame 1603. Clamping electric cylinder; 1604. Clamping plate; 1605. Clamping cone; 1606. Discharge roller; 1607. Discharge trough; 1608. Air inlet pipe; 17. Cutting unit; 1701. Cutting frame; 1702. Pressing roller; 1703. Cutting knife; 1704. Material picking clamp; 1705. Pushing electric cylinder; 18. Guide flat tube; 1801. Discharge port; 1802. Guide roller; 1803. Storage box; 19. Conveyor frame; 20. Limiting partition. Detailed Implementation
[0019] The specific embodiments of the present invention will be described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments.
[0020] like Figure 1 As shown in the embodiment of the present invention, a sterile isolation mixing device for pharmaceuticals is provided, including a glove box 1. The glove box 1 is equipped with an unpacking and feeding mechanism, which includes a material transfer and unpacking component for unpacking raw materials and a tilting component for tilting and pouring the packaging. By setting up the unpacking and feeding mechanism, the present application automatically completes the unpacking and feeding operations of solid raw materials inside the glove box 1, avoiding the problems of high operation difficulty and slow unpacking speed caused by manually using the glove box 1 for unpacking operations, improving the automation level of the device, and thus improving the mixing efficiency.
[0021] Please see Figure 2 and Figure 3 The material transfer and unpacking assembly includes a material transfer guide rail 5, a lifting electric cylinder 6 is slidably installed on the inner wall of the material transfer guide rail 5, and a cutting unit 17 is fixedly connected to the output end of the lifting electric cylinder 6. By setting the cooperation between the material transfer guide rail 5 and the lifting electric cylinder 6, the cutting unit 17 is driven to move horizontally and vertically, thereby realizing the movement of the solid raw material packaging bag and facilitating the flexible cooperation between the components. In one embodiment, see Figure 3 and Figure 5 The cutting unit 17 includes a cutting frame 1701, with a cutting cavity in the middle of the cutting frame 1701. A pressure roller 1702 is rotatably mounted on the top of the inner wall of the cutting cavity. The pressure roller 1702 is used to limit and fix the top of the bag opening of the packaging bag and assist in tensioning it to facilitate cutting. At the same time, the rotation of the pressure roller 1702 can press and hold the cut bag opening edge temporarily, and send it out when necessary, so as to realize the continuous cutting operation. A pusher cylinder is fixedly installed on the bottom of the inner wall of the cutting cavity. 1705, the output end of the push electric cylinder 1705 is fixedly connected to the cutting blade 1703, and the material picking clamp 1704 is fixedly installed below the cutting frame 1701. By setting the push electric cylinder 1705 to drive the cutting blade 1703 to move, the opening operation of the packaging bag is realized, and the clamping operation of the material picking clamp 1704 is used to clamp and transfer the packaging bag after the bag mouth is cut open, so as to move the material to the feeding position; a mixing hopper 3 is fixedly installed at the bottom of the inner wall of the glove box 1, and the bottom of the mixing hopper 3 is connected to the discharge pipe 4.
[0022] In one embodiment, see Figure 4 To assist in emptying the materials inside the packaging bag, the emptying assembly includes a tilting motor. The output end of the tilting motor is fixedly connected to a tilting disc 15, and a bag bottom limiting unit 16 is fixedly connected to one side of the tilting disc 15. Please refer to [link / reference]. Figure 6 and Figure 7 The bag bottom limiting unit 16 includes a support frame 1601, with clamping frames 1602 fixedly installed on both sides of the support frame 1601. Clamping electric cylinders 1603 are fixedly installed inside the two clamping frames 1602, and clamping plates 1604 are fixedly connected to the output ends of the two clamping electric cylinders 1603. The bag bottom limiting unit 16 supports the packaging bag from the bottom, which can reduce the force fluctuation of the material picking clamp 1704, and more stably realize the adjustment of the posture of the packaging bag, so as to realize the stable tilting and feeding of the packaging bag. By setting the clamping electric cylinders 1603 to drive the clamping plates 1604 to move, the stable clamping and limiting of packaging bags of different sizes can be realized, improving their stability during the tilting and moving process.
[0023] In one embodiment, to improve the limiting stability of the bag bottom limiting unit 16 on the packaging bag, several clamping cones 1605 are fixedly connected to the middle of the two clamping plates 1604. In order to achieve stable discharge of solid materials inside the packaging bag and reduce material loss and waste, air needles are fixedly installed in the middle of the several clamping cones 1605. One end of the several air needles is connected to an air inlet pipe 1608. An air pump is fixedly installed at one end of the air inlet pipe 1608. The air inlet end of the air pump is located inside the glove box 1 to avoid introducing external bacteria. In the final stage of material pouring, airflow is blown into the packaging bag by the air needles that pierce the packaging bag to fully discharge the residual material inside, so as to achieve full utilization of the material. In specific implementation, the airflow sent out by the air needles can also be used to blow and clean the residual material in the symmetrical measuring hopper 11.
[0024] In one embodiment, to facilitate the discharge of the finished packaging bag, discharge rollers 1606 are rotatably connected to one side edge of each of the two clamping frames 1602. (See also...) Figure 3 and Figure 4 The bottom of the support frame 1601 is provided with a discharge groove 1607, and the side of the receiving baffle 13 is provided with a discharge port 1801. The top of the discharge port 1801 is corresponding to the top of the discharge groove 1607. The bottom of the discharge port 1801 is fixedly connected with a guide tube 18. Several guide rollers 1802 are rotatably connected to the inner wall of the guide tube 18. One end of the guide tube 18 is inclined downward, and one end of the guide tube 18 is fixedly connected with a storage box 1803.
[0025] In one embodiment, see Figure 2 and Figure 3 To improve the uniformity of solid material mixing, a dispersing device is installed above the mixing hopper 3. The dispersing device includes a distributing frame 8, with a material distribution mesh 10 fixedly connected to the bottom of the distributing frame 8. A distributing motor is fixedly installed in the middle of the material distribution mesh 10, and a distributing trough 9 is fixedly connected to the output end of the distributing motor. The bottom of the distributing trough 9 has an opening, and the bottom of the opening is in close contact with the top of the material distribution mesh 10. The area of the material distribution mesh is smaller than the top area of the mixing hopper 3. The distributing motor drives the distributing trough 9 to rotate, causing the material to fall periodically and evenly through the material distribution mesh 10, thereby achieving uniform distribution and falling in the direction of the mixing hopper 3 and effectively preventing the material from clumping together, which would lead to uneven mixing and instability.
[0026] In one embodiment, see Figure 8To further improve the uniformity of mixing, for the liquid phase material during the stirring process, a solution pipe 7 is fixedly connected to one side of the stirring hopper 3, and several diversion drains 301 are fixedly connected to the inner wall of the stirring hopper 3. A connecting pipe is fixedly connected to the middle of each of the several diversion drains 301, and the several connecting pipes are connected to the solution pipe 7. Several diversion ports 302 are opened on one side of each of the several diversion drains 301, and the other side of each of the several diversion drains 301 is set as an inclined surface. An agitator 304 is installed in the stirring hopper. The liquid material is delivered through the dispersed diversion drains 301 and diversion ports 302, so that it circulates along the inner wall of the stirring hopper 3. This can effectively receive the falling solid material, thereby achieving uniform mixing of the material in continuous flow, avoiding the agglomeration of solid material, and preventing the adhesion of the remaining inner wall of the stirring hopper 3.
[0027] In one embodiment, to achieve mixing and automatic discharge control of materials, an installation platform 303 is fixedly connected to the bottom of the inner wall of the mixing hopper 3. The edge of the installation platform 303 is provided with a discharge chute for material to pass through. A discharge electric cylinder is fixedly installed below the installation platform 303. A sealing plug is fixedly connected to the output end of the discharge electric cylinder. The top of the sealing plug is correspondingly set with the discharge chute. The agitator 304 is fixedly installed on the installation platform 303.
[0028] In one embodiment, to achieve quantitative control of the falling solid raw materials, a top cover plate is fixedly connected to the top of the fabric rack 8. A feeding port is opened at the top of the top cover plate, and a weighing hopper 11 is installed at the top of the feeding port. A quantitative controller is installed inside the weighing hopper 11 to control the quantitative feeding of solid materials. This can be implemented using existing technology. In this embodiment, the quantitative controller includes a feeding motor, and a weighing plate is fixedly connected to the output end of the feeding motor. A weighing sensor (not shown in the figure) is fixedly installed inside the weighing plate.
[0029] In one embodiment, see Figure 2 To reduce the spillage of solid raw materials during feeding and movement, a receiving baffle 13 is fixedly connected to the top of the weighing hopper 11, and the edge of the receiving baffle 13 is bent upward; both sides of the inner wall of the weighing hopper 11 are fixedly connected to feed baffles 12, and both feed baffles 12 are inclined downward to the side that is closer to each other.
[0030] In one embodiment, see Figure 1 and Figure 2To achieve automated feeding of solid raw materials, a feeding box 2 is fixedly installed on one side of the glove box 1. A through groove is provided at the connection between the feeding box 2 and the glove box 1. Flexible baffles are fixed on the inner wall of the through groove. A conveyor frame 19 is fixedly installed inside the feeding box 2. A feeding conveyor belt 14 is rotatably installed on the inner wall of the conveyor frame 19. Several limiting baffles 20 are fixedly connected to the surface of the feeding conveyor belt 14. In specific implementation, a stable control device, such as a semiconductor cooling chip or a heat conduction pipe embedded in the box wall of the feeding box 2, can be set inside the feeding box 2 to achieve a temperature control method that does not introduce external media into the box environment, so as to ensure that the temperature of the solid raw materials is appropriate and to ensure their activity.
[0031] In use, the present invention is used in a sterile and clean closed equipment room. The bagged solid raw materials to be mixed are placed into the feeding conveyor belt 14 with the bag opening facing upward by the external feeding equipment, and are divided and placed one by one by the limiting partitions 20. During the mixing operation, the material transfer guide rail 5 drives the lifting cylinder 6 and the cutting unit 17 to move above the feeding conveyor belt 14. Then, the lifting cylinder 6 and the cutting unit 17 move down, allowing the top edge of the bag opening of the solid raw material to pass into the cutting chamber. At this time, the rotation of the pressing roller 1702 clamps the top of the bag opening and pulls it upward to straighten and tighten it. At the same time, the material picking clamp 1704 clamps the top of the packaging bag. Then, the pushing cylinder 1705 drives the cutting blade 1703 to move and cut off the top edge of the bag opening. After that, the lifting cylinder 6 drives the cutting unit 17 to lift up, and then the material transfer guide rail... 5. The cutting unit 17 and the bagged solid material held thereon are moved to the bottom limiting unit 16 of the bag. The bottom of the bagged solid material is then positioned between the two clamping frames 1602 of the support frame 1601 by the lifting cylinder 6 below. Then, the cutting unit 17 is moved above the weighing hopper 11 by the transfer guide rail 5, and then pushed downwards by the lifting cylinder 6 until it and the top of the bagged solid material held thereon are moved below the feed baffle 12. Then, the material removal clamp 1704 is released, allowing the material to flow out of the bag and into the weighing hopper 11. Simultaneously, the tilting motor drives the tilting disc 15 to rotate, and the material is fed into the weighing hopper 11. The rotating support frame 1601 assists in adjusting the posture of the bagged solid raw materials, causing the bag opening to gradually face downwards to complete the unloading of the solid materials. Once the rotating disc 15, driven by the rotating motor, rotates to make the bag vertically downwards, the air pump starts, sending airflow through the air inlet pipe 1608 into the air needle and blowing it into the bag to fully expel any remaining material and reduce waste. Then, the rotating motor rotates in the opposite direction, driving the rotating disc 15 to rotate and resetting the support frame 1601. After resetting, the discharge slot 1607 of the support frame 1601 aligns with the discharge port 1801, allowing the material to be discharged. The electric cylinder 1603 drives the clamping plate 1604 to retract, causing the air needle to disengage from the packaging bag. Then, the discharge roller 1606 rotates, pushing the packaging bag through the discharge groove 1607 and the discharge port, and then guiding it into the flat tube 18. The rotation of the guide roller 1802 then sends it out into the storage box 1803. Then, the material transfer guide rail 5 drives the cutting unit 17 to move above the support frame 1601. The clamping roller rotates in the opposite direction, pushing the cut bag top edge into the support frame 1601. Then, the rotation of the guide roller 1802 sends it out through the discharge groove 1607 and the discharge port 1801. Then, the weighing sensor of the weighing hopper 11 weighs the preset weight of solid material, and the feeding motor rotates to drive the material into the feeding frame 8. The feeding motor drives the feeding frame 8 to rotate, so that the material passes through the distribution mesh 10 and falls down gradually. At the same time, the solution pipe 7 connects to the liquid phase material and sends it out through the diversion drain 301 and the diversion port 302, which are fully mixed with the solid material in the mixing hopper 3. The agitator 304 is started to mix and stir the material. During the stirring, the operator can use the glove operating port on the glove box 1 to assist in the operation. After the stirring is completed, the discharge electric cylinder drives the sealing plug to move down and open the discharge chute. The stirred material is sent out through the discharge pipe 4.
[0032] The above-disclosed embodiments are merely a few specific examples of the present invention. However, the embodiments of the present invention are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.
Claims
1. A sterile, isolated drug mixing device for pharmaceutical use, characterized in that, Includes a glove box (1), the inside of which is provided with a packing and feeding mechanism, the packing and feeding mechanism including a material transfer and packing component for unpacking raw materials and a tipping component for flipping and tipping the packaging; The material transfer and unpacking assembly includes a material transfer guide rail (5), a lifting electric cylinder (6) is slidably installed on the inner wall of the material transfer guide rail (5), a cutting unit (17) is fixedly connected to the output end of the lifting electric cylinder (6), the cutting unit (17) includes a cutting frame (1701), a cutting cavity is opened in the middle of the cutting frame (1701), a pressing roller (1702) is rotatably installed on the top of the inner side wall of the cutting cavity, a pushing electric cylinder (1705) is fixedly installed on the bottom of the inner side wall of the cutting cavity, a cutting blade (1703) is fixedly connected to the output end of the pushing electric cylinder (1705), a material picking clamp (1704) is fixedly installed below the cutting frame (1701), and a mixing hopper (3) is fixedly installed on the bottom of the inner wall of the glove box (1).
2. The pharmaceutical sterile isolation mixing device as described in claim 1, characterized in that, The tilting assembly includes a tilting motor, the output end of which is fixedly connected to a tilting disc (15). A bag bottom limiting unit (16) is fixedly connected to one side of the tilting disc (15). The bag bottom limiting unit (16) includes a support frame (1601). Clamping frames (1602) are fixedly installed on both sides of the support frame (1601). Clamping electric cylinders (1603) are fixedly installed inside the two clamping frames (1602). Clamping plates (1604) are fixedly connected to the output ends of the two clamping electric cylinders (1603).
3. The pharmaceutical sterile isolation mixing device as described in claim 2, characterized in that, Several clamping cones (1605) are fixedly connected to the middle of the two clamping plates (1604). Air needles are fixedly installed in the middle of the several clamping cones (1605). One end of the several air needles is connected to an air inlet pipe (1608). An air pump is fixedly installed at one end of the air inlet pipe (1608).
4. The pharmaceutical sterile isolation mixing device as described in claim 2, characterized in that, A dispersing device is provided above the mixing hopper (3). The dispersing device includes a distributing frame (8). A material distribution mesh (10) is fixedly connected to the bottom of the distributing frame (8). A distributing motor is fixedly installed in the middle of the material distribution mesh (10). A material distribution trough (9) is fixedly connected to the output end of the material distribution motor. An opening is provided at the bottom of the material distribution trough (9). The bottom of the opening is in contact with the top of the material distribution mesh (10).
5. A pharmaceutical aseptic mixing device as described in claim 4, characterized in that, The top of the fabric rack (8) is fixedly connected to an upper cover plate, and the top of the upper cover plate is provided with a feeding port, and the top of the feeding port is provided with a weighing hopper (11).
6. The pharmaceutical sterile isolation mixing device as described in claim 5, characterized in that, The weighing hopper (11) is fixedly connected to a receiving baffle (13), the edge of which is bent upward; both sides of the inner wall of the weighing hopper (11) are fixedly connected to feed baffles (12), and both feed baffles (12) are inclined downward toward the side that is closer to each other.
7. The pharmaceutical sterile isolation mixing device as described in claim 1, characterized in that, A feeding box (2) is fixedly installed on one side of the glove box (1). A through groove is provided at the connection between the feeding box (2) and the glove box (1). A conveyor frame (19) is fixedly installed inside the feeding box (2). A feeding conveyor belt (14) is rotatably installed on the inner wall of the conveyor frame (19). Several limiting partitions (20) are fixedly connected to the surface of the feeding conveyor belt (14).
8. A pharmaceutical aseptic mixing device as described in claim 6, characterized in that, The two clamping frames (1602) are rotatably connected to one side edge of each of them. The bottom of the support frame (1601) is provided with a discharge groove (1607). The side of the receiving baffle (13) is provided with a discharge port (1801). The top of the discharge port (1801) is corresponding to the top of the discharge groove (1607). The bottom of the discharge port (1801) is fixedly connected with a guide tube (18). One end of the guide tube (18) is fixedly connected with a storage box (1803).
9. A pharmaceutical aseptic mixing device as described in claim 1, characterized in that, A solution pipe (7) is fixedly connected to one side of the stirring hopper (3). Several diversion water drains (301) are fixedly connected to the inner wall of the stirring hopper (3). A connecting pipe is fixedly connected to the middle of each of the several diversion water drains (301). The several connecting pipes are connected to the solution pipe (7). Several diversion ports (302) are opened on one side of each of the several diversion water drains (301). The other side of each of the several diversion water drains (301) is set as an inclined surface. A stirrer (304) is provided in the stirring hopper.
10. A pharmaceutical sterile isolation mixing device as described in claim 9, characterized in that, The bottom of the inner wall of the mixing hopper (3) is fixedly connected to an installation platform (303). The edge of the installation platform (303) is provided with a discharge chute for material to pass through. A discharge electric cylinder is fixedly installed below the installation platform (303). A sealing plug is fixedly connected to the output end of the discharge electric cylinder. The top of the sealing plug is set corresponding to the discharge chute.