Traditional Chinese medicine composition for preventing and treating cerebral arterial thrombosis and preparation method thereof

Abstract

The invention belongs to the technical field of Chinese herbal medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating cerebral arterial thrombosis and a preparation method thereof. The traditional Chinese medicine composition comprises leeches, earthworms, miscanthus, pseudo-ginseng, astragalus membranaceus, poria cocos, almonds, peach kernels, angelica sinensis, immature bitter orange, radix polygoni multiflori preparata, pericarpium citri reticulatae, carthamus tinctorius, liquorice and borneol flakes. By combining the traditional Chinese medicines, the traditional Chinese medicine composition has a remarkable treatment effect on preventing and treating cerebral arterial thrombosis. In addition, the traditional Chinese medicine composition disclosed by the invention is high in safety and definite in curative effect, and has a wide application prospect in the field of prevention and treatment of cerebral arterial thrombosis.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and specifically relates to a traditional Chinese medicine composition and preparation method for the prevention and treatment of ischemic stroke. Background Technology

[0002] Stroke, commonly known as "cerebrovascular accident," is an acute manifestation of cerebrovascular disease, named for its sudden onset and rapid progression. It mainly includes two categories: ischemic stroke (cerebral vascular occlusion) and hemorrhagic stroke (cerebral vascular rupture), both related to brain tissue damage caused by interruption of cerebral blood flow or hemorrhage.

[0003] The current situation of stroke incidence in China can be summarized as follows: the disease burden is extremely heavy, and it is characterized by "three highs": high incidence, high disability and mortality, and high recurrence rate. At the same time, the age of onset is trending younger.

[0004] The total number of stroke patients in China exceeds 28 million. A new stroke occurs approximately every 12 seconds, and a stroke causes death approximately every 21 seconds. Stroke is the leading cause of death and disability among adults in China. About 75% of surviving patients are left with varying degrees of disability, and the recurrence rate within 5 years of onset is as high as 40%, which is 2-3 times higher than in Europe and the United States.

[0005] Ischemic stroke accounts for about 80% of all stroke cases in China; approximately 8 out of every 10 stroke patients suffer from ischemic stroke. Over the past 30 years, the number of ischemic stroke cases in China has surged by 201.13%, far exceeding the global average growth rate. Meanwhile, the incidence of hemorrhagic stroke is declining. This means that the proportion of ischemic stroke continues to expand.

[0006] Hypertension has consistently been the leading risk factor for ischemic stroke over the past 30 years. Current public health and disease control strategies are focusing on curbing the rapid increase in ischemic stroke through measures such as controlling hypertension and lifestyle modifications. A 2025 report, "China Neurological Diseases Report 2024," also indicates that the vast majority of ischemic strokes can be prevented early by controlling risk factors. The incidence of ischemic stroke in China is severe, making it a priority area for public health. Controlling core risks such as hypertension and strengthening early screening and management of high-risk groups are key to reversing this trend.

[0007] Currently, routine diagnostic and treatment techniques for ischemic stroke typically include:

[0008] The procedure employed was minimally invasive endovascular thrombectomy.

[0009] Drug treatment: Intravenous thrombolysis (recombinant tissue-type lysozyme activator)

[0010] Anticoagulation therapy: Medications (warfarin, dabigatran, rivaroxaban, aspirin, clopidogrel, etc.)

[0011] While the aforementioned treatments have yielded some therapeutic effects, they only alleviate the apparent symptoms of ischemic stroke and cannot completely cure it. Patients often experience relapses or recurrences during treatment, and long-term drug therapy can lead to decreased drug sensitivity and tolerance, limiting further clinical application. Furthermore, the side effects of the medications cause varying degrees of damage to the patient's body.

[0012] With the vigorous development of traditional Chinese medicine (TCM) technology, TCM prescriptions are increasingly attracting attention due to their advantages such as fewer side effects, addressing both the symptoms and root cause, lower treatment costs, and reduced national medical expenses and economic burden on patients. Therefore, developing an economical and effective TCM composition for the prevention and treatment of ischemic stroke has significant theoretical and practical implications in the field of ischemic stroke prevention and treatment. Summary of the Invention

[0013] To overcome the shortcomings of existing knowledge and technology, this invention utilizes a traditional Chinese medicine (TCM) composition for the treatment of ischemic stroke. A synergistic TCM composition with additive effects was developed by applying a multi-ingredient, linear computational model. The purpose of this invention is to provide a TCM composition for the prevention and treatment of ischemic stroke and its application. The TCM composition provided by this invention exhibits good preventive and therapeutic effects against ischemic stroke.

[0014] Modern medical research has proven that due to persistently high levels of blood lipids, blood sugar, and uric acid, the microcirculation of blood vessels in the brain is blocked by "sugar deposits or salt deposits," obstructing blood flow. The body then naturally initiates a stress response, increasing blood pressure to meet the brain's blood supply needs. This is the main cause of hypertension, accounting for 95% of cases. Hypertension is also a major culprit in ischemic stroke.

[0015] Ischemic stroke can be divided into two categories: acute and chronic.

[0016] Acute ischemic stroke: This is caused by the detachment of plaques from the coronary arteries, carotid arteries, and vertebral arteries, leading to blockage of the basal brainstem. It has an extremely high mortality rate. These patients typically don't have high blood pressure and rarely experience symptoms like headaches, dizziness, or headaches, leading to insufficient awareness of the risks.

[0017] Chronic ischemic stroke is caused by blockage of the microcirculation of capillaries in the brain by "glucose deposits" or "salt deposits," which can lead to hemiplegia, a vegetative state, or even death. These patients typically have high blood pressure and frequently experience headaches, dizziness, and other symptoms, requiring long-term use of antihypertensive medication to control their blood pressure.

[0018] Patients with diabetes and high uric acid are the "main force" of hypertension patients, accounting for more than 85% of all patients. Patients with long-term high adrenaline or cervical spondylosis may also develop hypertension, and these patients are not sensitive to antihypertensive drugs.

[0019] Therefore, in the treatment of ischemic stroke, it is important to emphasize syndrome differentiation and treatment. This not only involves addressing the symptoms themselves but also considering factors such as the patient's etiology, physical condition, and emotions, and adopting comprehensive treatment measures to achieve both symptomatic and root-cause relief.

[0020] Based on the aforementioned theories regarding the causes of ischemic stroke, the technical solution proposed in this invention is: a traditional Chinese medicine composition and preparation method for the prevention and treatment of ischemic stroke, mainly composed of the following raw materials in parts by weight: leech 4-15 parts, earthworm 2-7 parts, worm 1-5 parts, Panax notoginseng 4-15 parts, Astragalus membranaceus 4-15 parts, Poria cocos 3-9 parts, apricot kernel 2-7 parts, peach kernel 2-7 parts, Angelica sinensis 3-9 parts, Citrus aurantium 2-7 parts, processed Polygonum multiflorum 1-5 parts, tangerine peel 2-7 parts, safflower 1-5 parts, licorice 2-7 parts, and borneol 1-3 parts.

[0021] The medicinal properties and effects of each herbal raw material in the herbal composition of the present invention are described below:

[0022] The formula uses leeches, earthworms, and mantis shrimp as the principal ingredients to break up blood stasis and remove blood clots; Panax notoginseng, peach kernel, and safflower as the assistant ingredients to invigorate blood and remove blood stasis; Astragalus membranaceus, Angelica sinensis, tangerine peel, immature bitter orange, Poria cocos, apricot kernel, prepared Polygonum multiflorum, and licorice root as the adjuvant ingredients to replenish qi and promote circulation; and borneol as the guiding ingredient to open the orifices and relieve stagnation. It has the effects of breaking up blood stasis, invigorating blood and removing blood stasis, replenishing qi and promoting circulation, and opening the orifices and relieving stagnation.

[0023] Leeches: They are salty and neutral in nature, and their function is to break up blood stasis and remove blood clots. They are black in color and have a putrid smell. They are good at entering the blood and breaking up blood stasis without harming new blood.

[0024] Earthworm: It is salty and cold in nature, and its properties are mobile and penetrating. It is used for its effects of promoting blood circulation, anticoagulation and unblocking collaterals.

[0025] Mangchong: It is bitter and cool in nature, and its effects are to remove blood stasis, break up accumulations and promote menstruation, especially good at treating blood stasis.

[0026] Panax notoginseng: It has a bitter and neutral nature. Its functions include dispersing blood stasis and reducing swelling, promoting blood circulation and stopping bleeding. It can resolve blood stasis without harming new blood, so it can treat all blood diseases.

[0027] Peach kernel: It has a bitter and sweet taste and functions to promote blood circulation, remove blood stasis and promote blood flow. It is a special medicine for blood stasis and blood stasis, so it can be used for blood clotting.

[0028] Safflower: It is pungent and warm in nature, and its effects include promoting blood circulation and regulating menstruation. It is a qi-regulating herb in the blood, especially good at promoting blood circulation, regulating blood, and clearing the meridians.

[0029] Astragalus: It is sweet and warm in nature. Its functions include tonifying the middle energizer and replenishing qi, as well as boosting qi, replenishing primordial qi, strengthening defensive qi, and effectively replenishing the qi of the whole body.

[0030] Angelica sinensis: It is sweet, pungent and warm in nature. Angelica sinensis is mainly used for diseases of the blood, nourishing and harmonizing the blood, especially nourishing the heart blood. It is a holy medicine for blood. When used with Astragalus membranaceus, it can unblock blood vessels and replenish qi and blood.

[0031] Dried tangerine peel: It is pungent and warm in nature, and its functions include regulating qi and strengthening the spleen, relieving phlegm and saliva, and is used for its function of regulating qi and drying dampness.

[0032] Fructus Aurantii Immaturus: It is bitter and cold in nature, and its functions are to promote qi circulation, eliminate stagnation, and relieve abdominal distension.

[0033] Poria cocos: It has a sweet and bland taste and functions to drain dampness and promote urination, benefit the spleen and stomach, calm the mind and soothe the nerves, and also promote the production of body fluids and eliminate dampness.

[0034] Almonds: They are bitter and warm in nature, and their functions include relieving stagnation, lowering qi, resolving phlegm, and clearing away stagnation in the qi level.

[0035] Prepared Polygonum multiflorum: It is sweet and warm in nature, and its effects are to nourish essence and blood, benefit blood and dispel wind. It specifically enters the liver and kidneys, nourishing both the innate true yin and the acquired nutritive blood.

[0036] Licorice: It is sweet and warm in nature, and has the most complete earth element. It is used to detoxify, harmonize the stomach, and regulate the effects of various medicines.

[0037] Plum blossom: It is bitter and cool in nature, and has the effects of being pungent and penetrating, and opening the orifices.

[0038] This invention utilizes the aforementioned combination of traditional Chinese medicines, which has significant therapeutic effects in the prevention and treatment of ischemic stroke. Patients assess the rehabilitation effect based on the degree of disability achieved during treatment and recovery.

[0039] Level 0 allows you to return to work or do housework;

[0040] Level 1: Self-sufficient in daily living, able to live independently, and partially work;

[0041] Level 2: Basic independent living, with some need for assistance;

[0042] Level 3: Can manage some daily activities independently, but requires assistance for most activities;

[0043] Level 4: Can stand and walk, but requires constant care;

[0044] Level 5 bedridden, able to sit up, requires assistance with all aspects of daily life;

[0045] Level 6 bedridden, with some consciousness and activity, can be fed;

[0046] Level 7 vegetative state.

[0047] As a preferred embodiment, the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke is mainly made from the following raw materials in parts by weight: leech 4-15 parts, earthworm 2-7 parts, worm 1-5 parts, Panax notoginseng 4-15 parts, Astragalus membranaceus 4-15 parts, Poria cocos 3-9 parts, apricot kernel 2-7 parts, peach kernel 2-7 parts, Angelica sinensis 3-9 parts, Citrus aurantium 2-7 parts, processed Polygonum multiflorum 1-5 parts, tangerine peel 2-7 parts, safflower 1-5 parts, licorice 2-7 parts, and borneol 1-3 parts.

[0048] A method for preparing a traditional Chinese medicine composition for the prevention and treatment of ischemic stroke as described above includes the following steps:

[0049] (1) Take the prescribed amounts of leech, earthworm, worm, Panax notoginseng, Astragalus membranaceus, Poria cocos, apricot kernel, peach kernel, Angelica sinensis, Citrus aurantium, processed Polygonum multiflorum, tangerine peel, safflower, licorice, and borneol, mix them, and then pulverize them to obtain ultrafine powder of Chinese medicine.

[0050] (2) The ultrafine powder of the Chinese herbal raw materials is mixed with water and stirred, then granulated and dried, and then filled into capsules to obtain a Chinese herbal composition capsule for the prevention and treatment of ischemic stroke.

[0051] (3) The capsule preparation is sterilized to obtain the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke.

[0052] As a preferred method, the pulverization process is cryogenic pulverization; the mesh size of the ultrafine powder is 1000~1200 mesh.

[0053] As a preferred method, the ultrafine powder of the raw materials is mixed evenly, and the ratio of the raw materials to room temperature purified water is 10:1.

[0054] As a preferred method, the uniformly mixed raw materials are granulated, and the diameter of the granules is 0.2~0.5mm.

[0055] As a preferred method, the raw material particles are dried at a temperature of 60 degrees Celsius for 2 hours.

[0056] As a preferred method, the dried microparticles are encapsulated, with a capsule content of 0.5g.

[0057] As a preferred method, the sterilization method employs radiation sterilization.

[0058] The preparation method of the traditional Chinese medicine composition of the present invention draws on the principle of the "ultra-high pressure micro-explosion process" of the cutting-edge technology of traditional Chinese medicine. The present invention preferably adopts the ultra-low temperature pulverization and cell wall breaking preparation process. Under normal temperature and pressure conditions, the same process effect of herbal composition preparation as the ultra-high pressure micro-explosion process is achieved, and the yield of effective components of raw materials reaches 100%.

[0059] Compared with traditional water extraction and alcohol extraction processes (effective component yield 26-31%), and supercritical fluid extraction and ultrasonic extraction processes (effective component yield 50-55%), the preparation process of this invention has the advantages of reducing raw material consumption by 4-5 times, achieving 100% effective component yield, producing highly effective drugs, and being pollution-free (no waste residue, no wastewater, no waste gas). This process not only reduces the raw material cost of the product and improves the utilization rate of social resources, but also greatly enhances the efficacy of the drug in treating diseases.

[0060] The use of a traditional Chinese medicine composition as described above or a traditional Chinese medicine composition prepared by the method described above in the preparation of a traditional Chinese medicine composition for the prevention and treatment of ischemic stroke, wherein the medicine is a traditional Chinese medicine solid capsule.

[0061] The technical solution of this invention has the following advantages and beneficial effects: The traditional Chinese medicine composition of this invention is based on the comprehensive pathogenesis of ischemic stroke and many years of clinical experience:

[0062] Regulate and control blood pressure levels to prevent and treat ischemic stroke.

[0063] Clear blockages in arteries and veins and microcirculation, preventing and treating ischemic stroke.

[0064] It can improve nutrition, enhance antioxidant and immune functions, and improve the body's self-healing ability.

[0065] Experiments have confirmed that the traditional Chinese medicine composition provided by this invention for the prevention and treatment of ischemic stroke has the following clear therapeutic effects in treating patients with ischemic stroke: (1) Significant improvement in symptoms of ischemic stroke (including: cognitive ability, language ability, facial expression, and limb movement); (2) Improvement in dizziness, headache, and dizziness, and blood pressure stabilization; (3) Improvement in patients' biochemical indicators: blood lipid indicators, blood glucose indicators, liver function indicators, kidney function indicators, etc., all show significant improvement; (4) Improvement in patients' imaging examination indicators: head CT examination, venous artery color Doppler ultrasound examination, coronary angiography examination, leg deep vein color Doppler ultrasound examination, etc., all show significant improvement; (5) No side effects: no adverse reactions were observed after patients consumed the medicine.

[0066] Therefore, this invention uses traditional Chinese medicine raw materials to prepare a product that significantly improves ischemic stroke, is safe to consume, has no adverse reactions, and uses common and widely available raw materials with stable processing technology, enabling large-scale industrial production. It has broad application prospects in the prevention and treatment of ischemic stroke. Detailed Implementation

[0067] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0068] Example 1

[0069] This embodiment provides a traditional Chinese medicine composition and preparation method for the prevention and treatment of ischemic stroke, which is made from the following traditional Chinese medicine raw materials in parts by weight: 12 parts leech, 6 parts earthworm, 2 parts worm, 12 parts Panax notoginseng, 12 parts Astragalus membranaceus, 6 parts Poria cocos, 6 parts apricot kernel, 6 parts peach kernel, 9 parts Angelica sinensis, 6 parts Citrus aurantium, 2 parts processed Polygonum multiflorum, 6 parts tangerine peel, 2 parts safflower, 6 parts licorice, and 1 part borneol.

[0070] This embodiment also provides a method for preparing the above-mentioned traditional Chinese medicine composition for the prevention and treatment of ischemic stroke, comprising the following steps:

[0071] (1) Take the prescribed amount of Chinese herbal raw materials (including leech, earthworm, worm, Panax notoginseng, Astragalus membranaceus, Poria cocos, apricot kernel, peach kernel, Angelica sinensis, Citrus aurantium, processed Polygonum multiflorum, tangerine peel, safflower, licorice, and borneol) and mix them. Then soak them in liquid nitrogen for 3 minutes and then pulverize them to obtain 1000-1200 mesh Chinese herbal ultrafine powder.

[0072] (2) Add 1 / 10 times the mass of the ultrafine powder of traditional Chinese medicine to room temperature purified water, mix and stir for 2 hours. After stirring evenly, add it to a granulator for granulation to obtain microparticles of 0.2~0.5mm. Place it in a dryer at 60 degrees Celsius for 2 hours and then air dry. Then put it into a capsule filling machine for capsule processing to obtain oral capsules of traditional Chinese medicine.

[0073] (3) The capsule product is placed in a 120mL medicine bottle, then sterilized by radiation for 45 minutes. Finally, the sterilized product is labeled and packaged to obtain the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke. According to the calculation, each 120mL oral capsule of the traditional Chinese medicine composition contains an effective amount of 60g.

[0074] Experimental Example 1: Typical Case

[0075] The treatment for typical cases is: 6 pills (containing 3g of medicine) of the traditional Chinese medicine composition of Example 1, taken orally 3 times a day, for a period of 30 to 150 days.

[0076] Typical Case 1: Male, 72 years old, from a state-owned enterprise. Diagnosed with ischemic stroke one year ago (manifestations: drooling, tongue biting, slurred speech, stumbling, etc.). Symptoms included hypertension, blurred vision, coronary heart disease, 73% stenosis of the left anterior descending coronary artery, and chest tightness and shortness of breath. He was treated with this traditional Chinese medicine combination for three months. All previously taken oral Western medications for lowering blood pressure, blood sugar, blood lipids, and uric acid were discontinued. His post-stroke sequelae were largely recovered, and his physical condition reached Level 1 (self-care, independent living, and partial work).

[0077] Typical Case 2: A 69-year-old male patient from Hebei Province. He was diagnosed with ischemic stroke one year ago (manifestations: slurred speech, facial drooping with drooling, intermittent crying, and inability to walk). After 35 days of treatment with this traditional Chinese medicine combination, he discontinued all his previous antihypertensive and hypoglycemic Western medications. The sequelae of the ischemic stroke essentially disappeared. He was able to walk 3 kilometers independently and ride a bicycle for leisure activities. His physical recovery reached Level 1 (self-care, independent living, and partial work).

[0078] Typical Case 3: Male, 61 years old, from Anhui Province. Diagnosed with ischemic stroke 4 years ago (manifested as vegetative state, bedridden for 4 years). After more than 20 days of treatment with this traditional Chinese medicine composition, the patient was able to get out of bed and move with assistance, with the help of a caregiver. After another 6 months of treatment, the patient recovered from level 7 (vegetative state) to level 5 (able to lie in bed, able to sit, but requiring assistance with all aspects of daily life).

[0079] Typical Case 4: Male, 73 years old, from Hebei Province. Diagnosed with ischemic stroke 17 years ago, recurring three times (manifested as: only able to sit, unable to stand, unable to walk, and with slurred speech). After 15 days of treatment with this traditional Chinese medicine combination, the patient's speech basically returned to normal, he was able to stand independently, and he could walk slowly with the help of a cane. After another 4 months of treatment, the patient recovered to level 4 (able to stand and walk, but requires constant care).

[0080] Case 5: A 68-year-old female patient from Beijing. She was diagnosed with ischemic stroke one month prior (presenting as a vegetative state, bedridden and aphasic). After 15 days of treatment with this traditional Chinese medicine combination, her speech largely returned to normal, and she was able to stand and walk slowly on her own. Following three months of treatment, she recovered to level 2 (basically independent living, requiring minimal assistance).

[0081] Case 6: Male, 46 years old, from Hainan. Diagnosed with ischemic stroke (manifestations: numbness in hands and feet, and immobility of the left side of the body). The onset was only half a month ago, which is considered the early stage. After one month of treatment with this traditional Chinese medicine combination, he recovered to level 0 (able to resume work, activities, or household chores). He is currently living and working normally and has not relapsed for 6 years.

[0082] Typical Case 7: Male, 57 years old, from Shandong Province. Diagnosed with ischemic stroke (manifestations: hypertension, bedridden, speech impairment). Three months after the onset of the stroke, he was treated with this traditional Chinese medicine combination for four months and recovered to Level 1 (self-care, independent living, partial work, slow speech). He currently lives and works normally and has not had a recurrence for two years.

[0083] Typical Case 8: Male, 35 years old, from Chengde. Diagnosed with ischemic stroke (manifested as vegetative state, unable to speak). After 3 months of treatment with this traditional Chinese medicine combination, he recovered to level 3 (able to manage some daily activities independently, but speaking is slower and there is some discomfort in his left leg when walking). He is currently living and working normally and has not had a recurrence for 5 years.

[0084] The above-described typical case analyses demonstrate that the traditional Chinese medicine composition of this invention, in the treatment of ischemic stroke patients, not only improves patients' physiological function indicators and alleviates their clinical symptoms, but also enhances their quality of life, with good safety profile. This brings new hope to patients with ischemic stroke. The efficacy evaluation of these cases provides strong evidence supporting the application of the traditional Chinese medicine composition of this invention in the treatment of ischemic stroke.

[0085] In summary, the traditional Chinese medicine composition provided by this invention can effectively improve the efficacy of ischemic stroke and has broad application potential in the prevention and treatment of ischemic stroke.

[0086] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for the prevention and treatment of ischemic stroke and its preparation method, characterized in that, It is mainly made from the following raw materials in parts by weight: leech 4-15 parts, earthworm 2-7 parts, worm 1-5 parts, Panax notoginseng 4-15 parts, Astragalus membranaceus 4-15 parts, Poria cocos 3-9 parts, apricot kernel 2-7 parts, peach kernel 2-7 parts, angelica sinensis 3-9 parts, Citrus aurantium 2-7 parts, processed Polygonum multiflorum 1-5 parts, tangerine peel 2-7 parts, safflower 1-5 parts, licorice 2-7 parts, and borneol 1-3 parts.

2. The traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to claim 1, characterized in that, It is mainly made from the following ingredients in parts by weight: 12 parts leech, 6 parts earthworm, 2 parts worm, 12 parts Panax notoginseng, 12 parts Astragalus membranaceus, 6 parts Poria cocos, 6 parts apricot kernel, 6 parts peach kernel, 9 parts Angelica sinensis, 6 parts Citrus aurantium, 2 parts processed Polygonum multiflorum, 6 parts dried tangerine peel, 2 parts safflower, 6 parts licorice, and 1 part borneol.

3. A method for preparing a traditional Chinese medicine composition for the prevention and treatment of ischemic stroke as described in claim 1, characterized in that, Includes the following steps: (1) Take the formula amount of leech, earthworm, worm, Panax notoginseng, Astragalus membranaceus, Poria cocos, apricot kernel, peach kernel, Angelica sinensis, Citrus aurantium, processed Polygonum multiflorum, tangerine peel, safflower, licorice and borneol, mix them together and then pulverize them to obtain ultrafine powder of Chinese medicine raw materials; (2) The ultrafine powder of the Chinese herbal raw material is mixed and stirred with room temperature pure water, then granulated and dried, and then filled into capsules to obtain capsules of the Chinese herbal composition for the prevention and treatment of ischemic stroke.

4. The method for preparing the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to claim 3, characterized in that, The pulverization process is ultra-low temperature pulverization; the mesh size of the ultrafine powder of the traditional Chinese medicine is 1000~1200 mesh.

5. The method for preparing the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to claim 3, characterized in that, The mixing ratio of the ultrafine powder to room temperature purified water is 10:

1.

6. The method for preparing the traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to claim 3, characterized in that, The granulation size is 0.2~0.5 mm.

7. A method for preparing a traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to any one of claims 3 to 6, characterized in that, The drying temperature is 60 degrees Celsius, and the drying time is 2 hours.

8. A method for preparing a traditional Chinese medicine composition for the prevention and treatment of ischemic stroke according to any one of claims 3 to 6, characterized in that, The capsule weighs 0.5 mg.

9. The application of a traditional Chinese medicine composition prepared according to claim 1 or the preparation method according to any one of claims 3 to 8 in the prevention and treatment of ischemic stroke, characterized in that... The traditional Chinese medicine composition is a solid oral capsule of traditional Chinese medicine.