Sleep-aiding preparation containing melatonin and plant extract and preparation method of sleep-aiding preparation

Abstract

The invention discloses a sleep-aiding preparation containing melatonin and plant extracts and a preparation method, the sleep-aiding preparation comprises the following raw materials: melatonin, a spina date seed extract, melissa essential oil, a passionflower extract and a valerian root extract, limited melatonin can avoid somnolence in the next day, low-concentration melissa essential oil can create a soothing atmosphere, and the sleep-aiding preparation can be used for preventing somnolence in the next day. The proportion of the spina date seed extract and the valerian root extract can reduce the risk of gastrointestinal tract stimulation, play a role in sedation and hypnosis and enhance the depth and duration of sleep, and the passion flower extract eliminates the inducement of sleep disorder and has the efficacy of improving sleep quality. The synergistic effect of the raw materials in precise proportion enables the preparation to have more obvious effects in the aspects of promoting sleep and improving sleep quality, and the safety is higher.

Description

Technical Field

[0001] This invention relates to the field of health and wellness, specifically to a sleep aid preparation containing melatonin and plant extracts, and its preparation method. Background Technology

[0002] Sleep disorders affect a large portion of the population, leading to various health problems such as weakened immunity, lethargy, and memory loss. Good sleep is an important guarantee for maintaining physical health and normal physiological functions, so people's demand for improving sleep is becoming increasingly urgent.

[0003] To improve sleep, people have explored various natural therapies to aid sleep, such as using plant extracts with sedative and calming effects. However, current sleep aids on the market have limitations in dosage form and usage, making it difficult to meet the needs of different groups. This invention aims to provide an effective method for preparing a sleep aid formulation that can be administered via a sprayer, aerosolizer, or nebulizer, helping people improve sleep in a more convenient and effective way. Summary of the Invention

[0004] The purpose of this invention is to provide a sleep aid preparation containing melatonin and plant extracts and a preparation method thereof, so as to solve the problem that the dosage form and usage of sleep aid products in the prior art are limited.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] In a first aspect, the present invention provides a sleep aid preparation containing melatonin and plant extracts, comprising the following raw materials: melatonin, jujube seed extract, lemon balm essential oil, passionflower extract and valerian root extract.

[0007] Furthermore, the above-mentioned sleep aid preparation contains the following parts by weight: melatonin 0.0003-0.005g, jujube seed extract 10-20g, lemon balm essential oil 0.01-0.08g, passionflower extract 10-20g, and valerian root extract 5-15g.

[0008] Furthermore, the aforementioned sleep aid preparation contains the following parts by weight: 0.0003 or 0.005g of melatonin, 10 or 20g of jujube seed extract, 0.01 or 0.08g of lemon balm essential oil, 10 or 20g of passionflower extract, and 5 or 15g of valerian root extract.

[0009] Furthermore, the aforementioned sleep aid preparation contains the following proportions by weight: 0.0012g melatonin, 15g jujube seed extract, 0.05g lemon balm essential oil, 15g passionflower extract, and 10g valerian root extract.

[0010] Furthermore, the pharmacological effects of the various ingredients in the above-mentioned sleep aid preparation are as follows:

[0011] Melatonin: Its core function is to regulate the body's circadian rhythm. It transmits sleep signals by binding to melatonin receptors in the suprachiasmatic nucleus of the hypothalamus, shortening the sleep latency and improving sleep maintenance. Within a ratio of 0.003%-0.05%, it can precisely regulate the body's biological clock, and is particularly effective for sleep rhythm disorders caused by jet lag, staying up late, etc.

[0012] Jujube seed extract contains jujube seed saponins, flavonoids and other components, which can act on the central nervous system, inhibit central excitation, and exert a sedative and hypnotic effect. It can prolong sleep time, improve sleep quality and has no obvious addictive properties.

[0013] Melissa essential oil: Its volatile components enter the body through the olfactory nerve, which can regulate the limbic system of the brain, relieve anxiety and tension, and thus indirectly promote sleep. Low concentrations of melissa essential oil can create a soothing atmosphere and enhance the effects of other sleep-aiding ingredients.

[0014] Passionflower extract: Contains flavonoids and other components that can inhibit excessive excitation of the central nervous system, and has sedative and anti-anxiety effects. It can relieve difficulty falling asleep caused by emotional tension. It works synergistically with jujube seed extract to enhance the sedative effect.

[0015] Valerian root extract: Its active ingredient, valerenoic acid, has a sedative and hypnotic effect. It can prolong deep sleep time and improve sleep structure.

[0016] On the other hand, the present invention provides a sleep aid preparation containing melatonin and plant extracts, and a method for preparing it, comprising the following steps:

[0017] S1 Extraction Process: The plant extracts were obtained by soaking and extracting the jujube seed, passionflower and valerian root in a solvent and then filtering them.

[0018] S2 Formula Mixing: The plant extracts obtained in step S1 are mixed with melatonin and lemon balm essential oil to form a mixed formula;

[0019] S3 Formulation Processing: The mixture prepared in step S2 is processed into a spray, aerosol, or atomizing agent.

[0020] Further, in step S1, jujube seed, passionflower and valerian root are extracted by soaking in ethanol or water under the following conditions: temperature 50-80℃ and soaking time 2-4 hours.

[0021] Further, in step S2, melatonin essential oil containing 0.3mg-5mg per dose and a concentration ratio of 0.1-0.8% is extracted and uniformly mixed with the plant extract obtained in step S1.

[0022] Further, the mixture prepared in step S2 is diluted with distilled water and filled into a container with an atomizing nozzle to form a spray.

[0023] Further, the mixed formulation prepared in step S2 is mixed with hydrofluoroalkane or dimethyl ether at a volume ratio of 30:70, and then filled into a pressure-resistant aerosol can to prepare an aerosol.

[0024] Further, adjust the viscosity of the mixed formulation prepared in step S2 to ≤5 cP, dispense it into single-dose containers, suitable for administration via electronic nebulizers or mesh nebulizers, to prepare an nebulizer.

[0025] Beneficial effects of the present invention

[0026] The low concentration of melatonin can prevent drowsiness the next day and regulate sleep rhythm to lay the foundation for overall sleep aid. The reasonable ratio of jujube seed extract and valerian root extract can reduce the risk of gastrointestinal irritation and exert sedative and hypnotic effects through different pathways, enhancing sleep depth and duration. The low concentration of lemon balm essential oil regulates mood through the sense of smell, and passion fruit extract relieves anxiety and eliminates the triggers of sleep disorders. The synergistic effect of this formula makes the preparation more effective in promoting sleep and improving sleep quality, and it is also safer. Detailed Implementation

[0027] The present invention will be further described in detail below with reference to the embodiments. The embodiments are only intended to provide a clearer understanding of the technical features, objectives and effects of the present invention, and are not intended to limit the present invention.

[0028] Example 1

[0029] The following raw materials were extracted and weighed in the following proportions: melatonin 0.0003g, jujube seed extract 10g, lemon balm essential oil 0.01g, passionflower extract 10g, and valerian root extract 5g.

[0030] Spray: Jujube seed, passion fruit and valerian root were soaked in ethanol for 3 hours. The plant extracts were then separated by filtration. The filtered jujube seed extract, passion fruit extract and valerian root extract were weighed and mixed evenly with melatonin and lemon balm essential oil. The mixture was diluted with distilled water and filled into a container with an atomizing nozzle to make a spray.

[0031] Aerosol: Jujube seed, passion fruit and valerian root were soaked in ethanol for 3 hours, and then filtered to obtain plant extracts. The filtered jujube seed extract, passion fruit extract and valerian root extract were weighed and mixed evenly with melatonin and lemon balm essential oil. This mixture was then mixed with the propellant hydrofluorocarbon at a volume ratio of 30:70. The mixture was then filled into a pressure-resistant aerosol can to make an aerosol.

[0032] Nebulizer: Soak jujube seed, passion fruit, and valerian root in ethanol for 3 hours, then filter and separate the plant extracts. Weigh the filtered jujube seed extract, passion fruit extract, and valerian root extract, and mix them evenly with melatonin and lemon balm essential oil. Adjust the viscosity of the mixture to ≤5 cP, dispense it into single-dose containers, and prepare the nebulizer for use with electronic nebulizers or mesh nebulizers.

[0033] Example 2

[0034] The following raw materials were extracted and weighed in the following proportions: melatonin 0.0012g, jujube seed extract 15g, lemon balm essential oil 0.05g, passionflower extract 15g, and valerian root extract 10g.

[0035] The preparation method is the same as in Example 1.

[0036] Example 3

[0037] The following raw materials were extracted and weighed in the following proportions: melatonin 0.005g, jujube seed extract 20g, lemon balm essential oil 0.08g, passionflower extract 20g, and valerian root extract 15g.

[0038] The preparation method is the same as in Example 1.

[0039] Comparative Example

[0040] The following raw materials were extracted and weighed in the following proportions: melatonin 0.1g, jujube seed extract 12g, lemon balm essential oil 0.05g, passionflower extract 12g, and valerian root extract 12g.

[0041] The preparation method is the same as in Example 1.

[0042] Test

[0043] Test subjects: Mice, 18-22g.

[0044] Experimental Description: Spray A1, aerosol B1, and nebulizer C1 were prepared using the formulation of Example 1; spray A2, aerosol B2, and nebulizer C2 were prepared using the formulation of Example 2; spray A3, aerosol B3, and nebulizer C3 were prepared using the formulation of Example 3; and spray A, aerosol B, and nebulizer C were prepared using the formulation of the comparative example. These were administered to mice.

[0045] Table 1: Tests using the formulation ratios from Example 1

[0046] Use of formulations Sleep latency (minutes) Sleep duration (hours) Spray A1 8 12 Aerosol B1 8 13 Atomizing agent C1 10 15

[0047] Table 2: Tests using the formulation ratios from Example 2

[0048] Use of formulations Sleep latency (minutes) Sleep duration (hours) Spray A2 9 14 Aerosol B2 8 12 Atomizer C2 8 15

[0049] Table 3: Tests using the formulation ratios from Example 2

[0050] Use of formulations Sleep latency (minutes) Sleep duration (hours) Spray A3 6 13 Aerosol B3 7 12 Atomizer C3 6 14

[0051] Table 4: Tests using the formulation ratios from Example 2

[0052] Use of formulations Sleep latency (minutes) Sleep duration (hours) Spray A 2 24 Aerosol B 3 25 Atomizer C 2 26

[0053] Based on Tables 1-4 above, it can be seen that the formulations in Examples 1, 2, and 3 enabled mice to quickly fall asleep. The control group, due to its excessively high melatonin content, while allowing rapid sleep, experienced a sleep duration of up to 24 hours. Furthermore, the mice's condition upon waking was observed; the mice using the control group formulation showed poor mental state upon waking. Therefore, precise formulation of raw materials can significantly promote sleep, improve sleep quality, and has a higher safety profile.

[0054] The embodiments of the present invention are merely specific descriptions of the technical solutions and are not intended to limit the technical solutions. Any substitutions or modifications made by those skilled in the art without changing the essential content of the present invention shall fall within the protection scope of the present invention.

Claims

1. A sleep aid preparation containing melatonin and plant extracts, characterized in that, It contains the following ingredients: melatonin, jujube seed extract, lemon balm oil, passionflower extract, and valerian root extract.

2. The sleep aid preparation according to claim 1, characterized in that, Prepared according to the following weight ratio: melatonin 0.0003-0.005g, jujube seed extract 10-20g, lemon balm essential oil 0.01-0.08g, passionflower extract 10-20g, valerian root extract 5-15g.

3. The sleep aid preparation according to claim 2, characterized in that, Prepared in the following weight ratios: melatonin 0.0003 or 0.005g, jujube seed extract 10 or 20g, lemon balm essential oil 0.01 or 0.08g, passionflower extract 10 or 20g, valerian root extract 5 or 15g.

4. The sleep aid preparation according to claim 2, characterized in that, Prepared according to the following weight ratio: melatonin 0.0012g, jujube seed extract 15g, lemon balm essential oil 0.05g, passionflower extract 15g, valerian root extract 10g.

5. The sleep aid preparation according to claim 1 or 2, characterized in that, The formulation can be made into sprays, aerosols, and atomizing agents.

6. The sleep aid preparation according to claim 1 or 2, characterized in that, The preparation method of the formulation includes the following steps: S1 Extraction Process: The plant extracts were obtained by soaking and extracting the jujube seed, passionflower and valerian root in a solvent and then filtering them. S2 Formula Mixing: The plant extracts obtained in step S1 are mixed with melatonin and lemon balm essential oil to form a mixed formula; S3 Formulation Processing: The mixture prepared in step S2 is processed into a spray, aerosol, or atomizing agent.

7. The method for preparing the sleep aid preparation according to claim 6, characterized in that, The solvent used in step S1 is ethanol or water, and the extraction conditions are: soaking and extraction time is 2-4 hours.

8. The method for preparing the sleep aid preparation according to claim 6, characterized in that, In step S2, the concentration of melatonin in the mixed formulation is 0.3mg-5mg per dose, the concentration of lemon balm essential oil is controlled at 0.1-0.8%, and the aroma intensity does not exceed the pharmacological effects of other active ingredients.

9. The method for preparing the sleep aid preparation according to claim 6, characterized in that, The dosage form processing in step S3 is as follows: Spray: The mixture prepared in step S2 is diluted with distilled water or a suitable carrier and filled into a container with an atomizing nozzle to form a spray. Aerosol: The mixture prepared in step S2 is mixed with a suitable propellant (hydrofluoroalkane, dimethyl ether or a combination thereof) at a volume ratio of 30:70 and filled into a pressure-resistant aerosol can to form an aerosol. Nebulizer: Adjust the viscosity of the mixed formulation prepared in step S2 to ≤5 cP, dispense it into single-dose containers, and prepare the nebulizer for administration via electronic nebulizers or mesh nebulizers.