Application of external medicinal liquor in preparation of medicine for treating gout

Abstract

The invention discloses application of external medicinal liquor in preparation of a medicine for treating gout, relates to the technical field of traditional Chinese medicines, and solves the problems of high cost, slow effect and adverse reaction of an existing ventilation treatment method. And the external medicinal liquor comprises dragon's blood, ephedra powder, cassia twig, safflower, ligusticum wallichii, red peony root, white peony root, beautiful sweetgum fruit, caltrop, fructus forsythiae, hedyotis diffusa, radix angelicae pubescentis, notopterygium root, salvia miltiorrhiza and white spirit. The preparation method comprises the following steps: drying the traditional Chinese medicine components, crushing, and putting into a three-dimensional motion mixer to obtain uniformly mixed traditional Chinese medicine powder; adding 5-8% by mass of white spirit, uniformly stirring, and activating in a vacuum drying oven; and then putting into the rest white spirit, covering, sealing and soaking for 7 days, and filtering to remove medicine residues to obtain the external medicinal liquor. The traditional Chinese medicine composition can be applied to treatment of gout diseases, and is low in cost, high in safety and quick in effect.

Description

TECHNICAL FIELD

[0001] The application relates to the technical field of traditional Chinese medicines, and particularly relates to application of an external medicinal liquor in preparation of a medicine for treating gout. BACKGROUND

[0002] Gout is a metabolic disease caused by high blood uric acid level due to disorder of purine metabolism and excretion of uric acid, and deposition of urate crystals in joints and surrounding soft tissues, cartilage, synovial membrane and other parts. The onset of gout is closely related to improper diet such as high purine diet, irregular work and rest, poor constitution, genetic factors and combined underlying diseases. Clinically, gout is characterized by sudden redness, swelling, heat and pain of joints, and often involves the first metatarsophalangeal joint, ankle joint, knee joint and other parts. The severe and recurrent pain can lead to joint deformity, dysfunction, gouty tophi and other complications such as uric acid nephropathy and kidney stones, and significantly reduces the quality of life of patients. Therefore, safe and effective treatment methods for gout have important clinical significance and application value.

[0003] At present, the treatment methods for gout mainly include oral drug therapy and non-drug therapy. Oral drug therapy is a conventional clinical treatment method, which includes uric acid-lowering drugs, acute attack period symptomatic treatment drugs and traditional Chinese medicine preparations. Among them, uric acid-lowering drugs regulate blood uric acid level by inhibiting uric acid generation or promoting uric acid excretion, symptomatic treatment drugs of western medicine mainly have anti-inflammatory and analgesic effects, and traditional Chinese medicine treatment is based on the pathogenesis of damp-heat stagnation, cold-dampness stagnation and phlegm and blood stasis, and the therapeutic principle is clearing heat and dampness, warming meridians and dispelling cold, resolving phlegm and resolving stasis. The body metabolism is regulated by the compatibility of traditional Chinese medicines. However, oral drugs need to be absorbed by the gastrointestinal tract, metabolized by the liver and excreted by the kidney. Long-term use of uric acid-lowering drugs may cause liver damage, gastrointestinal discomfort and other adverse reactions. Drugs such as colchicine and non-steroidal anti-inflammatory drugs are prone to cause nausea, vomiting, diarrhea and cardiovascular system risks. Some patients have poor tolerance to oral drugs due to differences in constitution or underlying diseases such as liver and kidney dysfunction. At the same time, the onset of drugs needs to go through the metabolism process in the body, and the remission of acute attack period joint pain lacks pertinence and the onset is delayed.

[0004] Non-drug therapy gradually attracts attention in the treatment of gout due to direct action on the local lesion, avoidance of systemic metabolic burden and less adverse reactions. Non-drug therapy mainly includes physical therapy, external preparation smearing and the like. Physical therapy such as cold compress and ultrasonic treatment can only temporarily relieve local swelling and pain, and cannot fundamentally improve urate deposition and inflammatory reaction. The commonly used external preparations in clinic are mainly western medicine gels or ordinary traditional Chinese medicine ointments. Western medicine gels mainly have local anti-inflammatory and analgesic effects, and have single action. Traditional Chinese medicine ointments often have problems such as low drug penetration efficiency and insufficient release of effective components.

[0005] In addition, in the external treatment of similar cold-dampness stagnation related diseases, the existing technology such as medicine wine rubbing therapy has been applied, but there are obvious defects. The raw materials of the medicine wine are various, and the soaking time is usually more than 6 months, resulting in high preparation cost and long period; the effective components of the medicine need to be separated out in a small amount after long-term soaking, and the skin penetration efficiency is limited when used externally, so that the therapy has slow effect, long treatment period and is difficult to quickly relieve the severe pain in the acute attack period of gout; at the same time, the high concentration of alcohol in the traditional medicine wine can easily damage the skin sebum layer, resulting in dry skin and barrier damage, and can also cause allergic reactions, especially for the damaged or sensitive joint skin in the acute attack period of gout, the irritation is stronger. In addition, non-drug methods such as fire therapy have high operation risks such as fire and burn due to the direct action of high-burning alcohol on the skin, and are not suitable for local treatment of gout joints at all.

[0006] In summary, in the existing treatment methods for gout, the internal medicine has the problems of high risk of adverse reactions and poor tolerance of some patients, the conventional physical physiotherapy has limited effect, and the existing external preparation and traditional medicine wine therapy have defects such as complicated preparation, high cost, slow effect, and strong skin irritation. Therefore, it is a technical problem to be solved at present to develop an external treatment method with high safety, simple preparation, controllable cost, rapid effect, and effective anti-inflammatory and analgesic effect, and to promote the metabolism of uric acid, so as to improve the clinical symptoms in the acute attack and chronic persistent period of gout. SUMMARY

[0007] In order to solve the problems of high cost, slow effect and adverse reactions of the existing gout treatment methods, the application of an external medicine wine in the preparation of a medicine for treating gout is proposed.

[0008] The technical scheme of the application is as follows: The application of an external medicine wine in the preparation of a medicine for treating gout, wherein the external medicine wine comprises the following components in mass fraction: 10-70 parts of dragon's blood, 10-70 parts of ephedra, 10-70 parts of cassia twig, 10-70 parts of safflower, 10-70 parts of chuanxiong, 10-70 parts of red peony root, 10-70 parts of white peony root, 10-70 parts of rue, 10-70 parts of tribulus terrestris, 10-70 parts of forsythia, 10-70 parts of leech, 60-120 parts of angelica pubescens, 60-120 parts of notopterygium, 60-120 parts of salvia miltiorrhiza, and 40000-60000 parts of white spirit; the alcohol content of the white spirit is 60-80%.

[0009] Preferably, the external medicine wine is prepared by the following steps: (1) drying each traditional Chinese medicine component to a water content of ≤8%, and crushing, then mixing in a three-dimensional motion mixer to obtain a mixed traditional Chinese medicine powder; (2) Add 5-8% of the mass of the mixed traditional Chinese medicine powder into the liquor, stir uniformly, and then place in a vacuum drying box for activation treatment; (3) Put the activated mixed traditional Chinese medicine powder into the remaining liquor, seal, soak for 7 days, filter out the dregs, and obtain the external use medicinal liquor.

[0010] Preferably, the crushing treatment in step (1) is specifically: crushing the notoginseng, notopterygium, and salvia miltiorrhiza to 100-120 meshes, crushing the dragon's blood, ephedra, cassia twig, safflower, chuanxiong, red peony root, white peony root, luffa, and tribulus terrestris to 120-150 meshes, and crushing the forsythia and lecanorchis to 150-200 meshes.

[0011] Preferably, the rotation speed of the mixing in step (1) is 30-50 r / min, and the mixing time is 15-20 min.

[0012] Preferably, the activation treatment in step (2) is specifically: treating under the conditions of a vacuum degree of-0.06 to-0.08 MPa and a temperature of 40-45 DEG C for 2-3 h.

[0013] Preferably, the external use medicinal liquor is placed in a container and ignited, and the ignited external use medicinal liquor is dipped with a hand wearing a ready-to-use tool to contact the body surface part.

[0014] Compared with the prior art, the specific beneficial effects of the present application are: The present application precisely selects traditional Chinese medicine components and scientifically matches them, each component forms a synergistic effect based on its own pharmacological characteristics, realizes efficient superposition in aspects of warming and dredging joints, clearing heat and dampness, promoting blood circulation and removing blood stasis, and promoting urate metabolism, and at the same time, considers the safety of drug use, precisely adapts to the core pathogenesis of gouty rheumatism turbid stasis and different treatment needs of acute attack and chronic period. Specifically, notoginseng is pungent and warm and goes up, is good at dispersing upper body damp turbid stasis, and is especially good at relieving the acid and swelling pain of gout involving knees and ankles; notoginseng is slightly warm and goes down, and is good at attacking lower body rheumatism, and is more targeted to the first metatarsophalangeal joint and ankle joint lesions of gout; the two are used together to form a turbid network of dredging collaterals covering the whole body joints, and comprehensively cope with the characteristics of multiple joint involvement of gout.

[0015] Ephedra is pungent and warm and opens, belongs to the lung and bladder meridians, can dredge joints and pores, and provides an outlet for urate crystals and damp turbid evil; cassia twig is sweet and warm and tonifies yang, can help ephedra to enhance the dispersing power, and can warm and dredge joints and meridians to disperse stasis and cold in deep collaterals, and avoid long-term deposition of damp turbid urate. With the help of chuanxiong, which is pungent and warm and moves qi, the effect of dispersing dampness and stasis by qi movement is used to make the warm and turbidity-dispersing power smoothly spread along the joint collaterals, quickly relieve the core symptoms of gout such as joint redness, swelling, heat and pain, and activity limitation, reduce urate residues from the source, and reduce the risk of joint deformity and gout stone formation.

[0016] Gout is a common chronic disease caused by the deposition of uric acid crystals in the joints, which can cause joint pain, swelling, and other symptoms. It is a common disease in the world, and its incidence is increasing year by year. Traditional Chinese medicine believes that gout is caused by the accumulation of dampness and turbidity in the body, and the treatment should be to remove dampness and turbidity, and promote blood circulation. The main treatment methods include clearing heat and removing dampness, promoting blood circulation, and removing blood stasis. The main treatment methods include clearing heat and removing dampness, promoting blood circulation, and removing blood stasis.

[0017] White peony root is sweet and slightly cold, and belongs to liver and spleen meridians. It nourishes blood and astringes yin, and soothes liver and relieves pain. It can restrict the dispersing nature of ephedra and cassia bark, and prevent the consumption of local blood and blood in the joint. Red peony root is bitter and cold, and can clear heat and cool blood, and remove blood stasis and relieve pain. It is astringent and dispersing, and can enhance the effect of removing blood stasis and protecting yin blood, and reduce the irritation of the skin of the sensitive or damaged joints in the acute stage of gout. Although Lonicera japonica and aconite both have a cooling effect, the amount and warm nature of the medicine form a precise balance, which can remove the trace of heat caused by dampness and turbidity, and perfectly adapt to the symptoms of redness and pain in the acute stage of gout. It can also be used for long-term conditioning in the chronic stage, expanding the application scenarios.

[0018] White wine is a long-term medicine, which can be used as a carrier and core medicine. It is warm and belongs to heart, liver, and spleen meridians. It can promote blood circulation and remove wind and cold, and directly respond to the effect of removing dampness and turbidity. At the same time, with the solvent properties of alcohol, the active ingredients of anti-inflammatory and analgesic, and the promotion of uric acid solubility in the preparation process of the medicine, the basic effect of the medicine is improved. The volatility and penetration of white wine can accelerate the absorption of drug components through the skin, so that the components of removing dampness and promoting blood circulation can quickly penetrate the skin, muscle, and bone, and directly reach the joint cavity and synovial membrane, and other uric acid deposition sites, solving the problem of slow effect of traditional external medicine and deep lesions. Especially for the deep uric acid deposition and joint deformity in the chronic stage of gout, the penetration of white wine can make the medicine more accurately act on the lesion, and shorten the conditioning period.

[0019] The present application only uses 14 kinds of traditional Chinese medicines, greatly simplifies the components compared with traditional medicinal liquor, and significantly reduces the preparation cost; the white liquor brewed from grains is selected, after soaking the traditional Chinese medicines, the medicinal liquor has low ignition point, can be extinguished by hand, has no fire hazard, has no cases of burn injury and scald in clinical application, has high safety, and is suitable for the self-care needs of gout patients at home; the soaking time is only 7 days, which is greatly shortened compared with the soaking period of more than 6 months of traditional medicinal liquor, and the preparation efficiency is significantly improved; the preparation process is simple, only 4 core processes are needed from drying and crushing of traditional Chinese medicines, activation treatment, soaking to filtration, energy and labor cost are effectively saved; and the acute pain of gout can be quickly relieved, the chronic period regulating course is short, the effect is quick, and the patient compliance is higher. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 The patient's pre-treatment examination report of the typical case 1 of the present application; Figure 2 The patient's post-treatment examination report of the typical case 1 of the present application. DETAILED DESCRIPTION

[0021] In order to make the technical solutions of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings of the specification of the present application. It should be noted that the following embodiments are only used to better understand the technical solutions of the present application, and should not be understood as a limitation of the present application.

[0022] Embodiment 1. The raw material components and quality of this embodiment are as follows: Dragon's blood 300g, Ephedra 300g, Cinnamomum 300g, Safflower 300g, Chuanxiong 300g, Red peony root 300g, White peony root 300g, Herba Ruta 300g, Tribulus terrestris 300g, Forsythia 300g, White flower snake grass 300g, Angelica pubescens 800g, Notopterygium 800g, Salvia miltiorrhiza 800g, White liquor 500000g; the alcohol content of the white liquor is 70%vol.

[0023] The specific preparation process is recorded as follows: (1) The above-mentioned traditional Chinese medicine components are respectively placed in a 40℃ hot air drying oven and dried to a moisture content of 7%, and then classified and crushed: Angelica pubescens, Notopterygium and Salvia miltiorrhiza are crushed to 110 mesh fine powder; Dragon's blood, Ephedra, Cinnamomum, Safflower, Chuanxiong, Red peony root, White peony root, Herba Ruta and Tribulus terrestris are crushed to 130 mesh fine powder; Forsythia and White flower snake grass are crushed to 180 mesh fine powder. All the traditional Chinese medicine fine powder meeting the particle size requirement is put into a three-dimensional motion mixer, mixed at a speed of 40r / min for 18min, and a mixed traditional Chinese medicine powder with uniform mixing is obtained.

[0024] (2) Take 6% of the total mass of the mixed traditional Chinese medicine powder of the white spirit, add it to the mixed traditional Chinese medicine powder, and quickly stir until there is no dry powder lump, then place it in a vacuum drying oven, activate it under the conditions of vacuum degree -0.07 MPa and temperature 42℃ for 2.5 hours, and obtain the activated traditional Chinese medicine powder.

[0025] (3) Put the activated traditional Chinese medicine powder into the remaining white spirit, pour it into a ceramic wine barrel with a sealed cover, stir to immerse the traditional Chinese medicine powder completely, tightly cover the cover, and place it in a 25℃ cool and ventilated place for 7 days of soaking. After soaking, first remove the large particle residues with a 200 mesh filter screen, then fine filter with a 0.45 μm filter membrane, and collect the filtrate as the external use medicinal liquor.

[0026] Example 2. The raw material components and mass of this example are as follows: Dragon's blood 500g, Ephedra 500g, Cinnamon Twig 500g, Safflower 500g, Chuanxiong 500g, Red Peony Root 500g, White Peony Root 500g, Herba Rorippae 500g, Forsythia 500g, White Flower Snake Grass 500g, Duhuo 1000g, Notopterygium 1000g, Salvia Miltiorrhiza 1000g, White Spirit 450000g; the alcohol content of the white spirit is 65%vol.

[0027] The specific preparation process is as follows: (1) Place each traditional Chinese medicine component in a 38℃ hot air drying oven and dry until the moisture content is 6%, then perform grading pulverization: pulverize Duhuo, Notopterygium, and Salvia Miltiorrhiza to 100 mesh fine powder; pulverize Dragon's Blood, Ephedra, Cinnamon Twig, Safflower, Chuanxiong, Red Peony Root, White Peony Root, Herba Rorippae to 120 mesh fine powder; pulverize Forsythia and White Flower Snake Grass to 150 mesh fine powder. Put all the traditional Chinese medicine fine powder into a three-dimensional motion mixer, mix under the condition of rotation speed 35 r / min for 16 min, and obtain mixed traditional Chinese medicine powder.

[0028] (2) Take 5% of the total mass of the mixed traditional Chinese medicine powder of the white spirit, add it to the mixed traditional Chinese medicine powder, stir evenly, and then place it in a vacuum drying oven, activate it under the conditions of vacuum degree -0.06 MPa and temperature 43℃ for 2 hours, and obtain the activated traditional Chinese medicine powder.

[0029] (3) Add the activated traditional Chinese medicine powder to the remaining white spirit, pour it into a stainless steel sealed wine barrel, stir evenly, seal, and place it in a 23℃ environment for 7 days of soaking. After soaking is completed, filter the residues through a 180 mesh filter screen, then remove the small impurities by centrifugal separation (rotation speed 3000 r / min, time 10 min), and collect the supernatant as the external use medicinal liquor.

[0030] Example 3. The raw material components and mass of this example are as follows: Dragon's blood 200g, Ephedra 200g, Cinnamomum 200g, Safflower 200g, Chuanxiong 200g, Red peony root 200g, White peony root 200g, Rosin 200g, Tribulus terrestris 200g, Forsythia 200g, White flower snake grass 200g, Duhuo 700g, Notopterygium 700g, Salvia miltiorrhiza 700g, White liquor 550000g; the alcohol content of the white liquor is 75%vol.

[0031] (1) Each traditional Chinese medicine component is placed in a 42℃ hot air drying oven and dried until the moisture content is 5%, and then classified and crushed: Duhuo, Notopterygium, and Salvia miltiorrhiza are crushed to 120 mesh fine powder; Dragon's blood, Ephedra, Cinnamomum, Safflower, Chuanxiong, Red peony root, White peony root, Rosin, and Tribulus terrestris are crushed to 150 mesh fine powder; Forsythia and White flower snake grass are crushed to 200 mesh fine powder. All the fine powder of traditional Chinese medicine is put into a three-dimensional motion mixer and mixed at a speed of 45r / min for 19min to obtain mixed traditional Chinese medicine powder.

[0032] (2) Activation of mixed traditional Chinese medicine powder: 8% of the total mass of mixed traditional Chinese medicine powder of white liquor is added to the mixed traditional Chinese medicine powder, and after being fully stirred to a uniform state, it is placed in a vacuum drying oven and activated at a vacuum degree of-0.08MPa and a temperature of 44℃ for 3h to obtain activated traditional Chinese medicine powder.

[0033] (3) Soaking and preparation of finished product: The activated traditional Chinese medicine powder is put into the remaining white liquor, injected into a sealed wine tank with a stirring device, and stirred for 5min to mix the materials uniformly. After sealing, it is placed in a 27℃ light-proof environment for 7 days of soaking. After soaking, it is sequentially filtered through a 200 mesh filter screen and a 0.3μm ceramic membrane, and the filtrate is collected to obtain an external use medicinal liquor.

[0034] Effect example An external use medicinal liquor is prepared according to the formula and process described in Example 1, and a patient is treated in the following manner: Prepare supplies: external use medicinal liquor, container, pure cotton gloves, disposable plastic gloves, disposable bed sheet, towel, and physiotherapy clothes.

[0035] Dip fire: after wearing the supplies, ignite the external use medicinal liquor in the container, separate the five fingers of the palm with the flame, and gently dip the palm with the ignited external use medicinal liquor until there is fire in the palm.

[0036] Shake fire: after the palm is brought to fire, the Qi of Dantian is poured into the palm, from top to bottom, aiming at the container, and instantly exerting force to shake off the excess external use medicinal liquor on the palm.

[0037] Burn fire: the palm is like a hawk's claw, and when burning fire, the five fingers are opened and slightly bent to relax, from the Spleen Shu point to the eight Liao points, and then back to the Spleen Shu point, repeatedly, until the fire in the palm is extinguished. If standing on the left body position, burn fire from the left side of the patient to the right side; if standing on the right body position, burn fire from the right side of the patient to the left side.

[0038] Fire: with the rhythm of the way, the power of medicine, wine, fire, heat directly to the lesion, wine, fire, and continue to fire, until the big, wind door, spleen, kidney, eight points, such as the whole body feel performance for a little hot and warm, you can stop fire, start to simmer.

[0039] Fire: the use of heat to exchange the cold and damp inside the body outside, cold and damp in the form of water, the time of simmering fire in accordance with the amount of external use of medicinal wine, the amount of external use of medicinal wine is 3~6 bottles, 250ml / bottle. The heavier the cold and damp, the more the amount of external use of medicinal wine, the longer the simmering time, every 250ml / bottle 5 minutes, simmering time is generally in 15~30 minutes; After simmering, the patient is the best, cold and damp in the form of water in the body, will not cause burns, scalds and other conditions.

[0040] The following gives the clinical experimental data.

[0041] 1、Clinical data: In this group of 100 cases, 55 cases were male and 45 cases were female, the youngest was 22 years old and the oldest was 75 years old, the course of disease was 3 months to 35 years. 2、Efficacy criteria: Recovery: symptoms and signs basically subsided, efficacy index ≥ 90%; Marked effect: symptoms and signs were significantly reduced, and the efficacy index was 60%-89%; Effective: symptoms and signs improved, efficacy index 5%-59%; No effect: no significant improvement in symptoms and signs, efficacy index <5%.

[0042] 3、Treatment: External use of medicinal wine acting on the dermis, according to the patient's symptoms, 250ml~1500ml each time, the external use of medicinal wine is ignited, the palm is dipped in fire, and the skin is burned along the meridian (fire), fire, simmering, once a day, 7 days for a course of treatment.

[0043] 4、Treatment results: After statistics, among the 100 patients in this group, 50 cases (50.0%) had significant effect, 49 cases (49.0%) were effective, and 1 case (1.0%) was ineffective, and the total effective rate was 99.0%.

[0044] 5、Typical cases: (1) Male, 51 years old, acute gout, blood uric acid value 513μmol / L, see Figure 1As shown, accompanied by the first metatarsophalangeal joint of the right foot redness, swelling, heat and pain, tenderness obvious, can not walk, night pain. After using the external medicine wine of the application, according to the application method of the application, the joint pain is significantly reduced, and the joint pain is significantly reduced. After 3 times of treatment, the redness subsides, the pain basically disappears, and the patient can walk normally. After 5 months of treatment, the blood uric acid value is 425 μmol / L, and the inspection report is shown in Figure 2 As shown, the symptoms are completely cured. After 3 months of follow-up, no recurrence is found.

[0045] (2) Female, 56 years old, chronic gout in remission, 8 years of history, left ankle joint repeated swelling and pain, local formation of about 1.2 cm diameter tophi, limited activity, blood uric acid value 612 μmol / L, joint ultrasound suggests urate crystal deposition. After using the external medicine wine of the application, according to the application method of the application, the joint swelling and pain is relieved; after 2 courses of treatment (2 weeks), the tophi is reduced to 0.8 cm, and the activity is improved; after 6 courses of treatment (6 weeks), the tophi is basically dispersed, the blood uric acid value is reduced to 398 μmol / L, and the patient can participate in daily activities normally. After 1 year of follow-up, no acute attack is found.

[0046] (3) Male, 58 years old, gout combined with hypertension, right knee joint acute attack for 3 days, joint redness, swelling and heat, pain VAS score 8, stomach discomfort after taking non-steroidal anti-inflammatory drugs. After using the external medicine wine of the application, according to the application method of the application, the pain VAS score is reduced to 4, and the stomach is not uncomfortable; after 2 times of treatment, the redness is reduced, and the pain VAS score is 2; after 5 times of treatment, the symptoms are completely relieved, and the blood uric acid is 435 μmol / L. After 2 months of follow-up, no recurrence is found, and the blood pressure is stable.

[0047] (4) Female, 32 years old, first gout attack, left ankle joint redness and pain, accompanied by low fever 37.8℃, blood uric acid 524 μmol / L, refused to take oral medicine due to preparation for pregnancy. After using the external medicine wine of the application, according to the application method of the application, the low fever subsides, and the joint pain is relieved; after 3 times of treatment, the redness completely subsides, and the activity is normal; after 10 days of treatment, the blood uric acid is 410 μmol / L, and the symptoms are cured. After 6 months of follow-up, no recurrence is found, and successful pregnancy is achieved.

[0048] (5) Male, 50 years old, gout in chronic stage with multiple joint involvement, pain and stiffness in both first metatarsophalangeal joints and right knee joint, more obvious in the morning, serum uric acid 568 μmol / L, long-term use of uric acid-lowering drugs still repeated discomfort. After using the external medicinal liquor of the application according to the application method for 1 course of treatment (1 week), the joint stiffness was reduced; after 3 courses of treatment (3 weeks), the joint pain basically disappeared and the activity was flexible; after 2 months of review, the serum uric acid was 402 μmol / L, and the follow-up was 8 months with only mild attack once. After using the external medicinal liquor of the application according to the application method for 2 times, the symptoms were relieved.

[0049] Comparative example. Select more than 20 kinds of traditional Chinese medicines, specifically including: Angelica 200g, Wind-preventing 200g, Gentiana 200g, Atractylodes 200g, Cyathula 200g, Eucommia 200g, Taxillus 200g, Acanthopanax 200g, Radix Cynanchi 200g, Sea wind 200g, Loxogenes 200g, Millettia 200g, Geumjogui 200g, Millettia 200g, Notopterygium 200g, Cinnamomum 200g, Ephedra 200g, Safflower 200g, Chuanxiong 200g, Salvia 200g, Peach kernel 200g, Olibanum 200g, Myrrh 200g, Corydalis 200g; Baijiu 400000g (alcohol content 65%vol), white vinegar 80000g.

[0050] Grind the above more than 20 kinds of traditional Chinese medicines to 2-3 cm, put them into a ceramic jar, then add Baijiu and white vinegar, stir with a bamboo chopstick for 3 times to preliminarily mix the materials, ensure that the traditional Chinese medicines are completely immersed in the liquid, seal the jar opening, and place it in a room temperature environment for 180 days of soaking. Open the jar, remove the dregs, and collect the filtrate as the finished medicinal liquor.

[0051] The patient was treated by the same method as the application. Compared with the indicators of the application example, the results are shown in Table 1.

[0052] Table 1

[0053] After comparison, it can be determined that the technical advantage of the application is that the number of raw materials is small, the cost is greatly reduced, the preparation efficiency is greatly improved, and the market and clinical demand can be quickly responded. The effect speed is improved by more than 60%, the patient's discomfort is quickly improved, and the safety is also significantly improved.

[0054] The present application solves the core defects of the existing gout external treatment technology, such as complex types of traditional Chinese medicines, long preparation period, insufficient dissolution of effective components, and high cost, through the process design of accurate component screening, classified crushing, and vacuum activation. The vacuum activation treatment can efficiently destroy the cell wall structure of traditional Chinese medicines, greatly improve the dissolution efficiency of effective components for anti-inflammatory and analgesic, promoting the dissolution and metabolism of urate, and achieve high dissolution effect without long-term soaking. The preparation period is shortened from 6 months of traditional medicinal liquor to within 10 days, and the cost is significantly reduced. In the components of the present application, Qianghuo and Duhuo work together to remove turbidity and dredge collaterals, and comprehensively cope with the characteristics of multiple joint involvement of gout. Longxuejie and Honghua precisely remove blood stasis and relieve pain, breaking the vicious cycle of turbid stasis and pain caused by stasis. Combined with the penetration of Baijiu, the effective components can quickly penetrate the skin and reach the joint cavity where urate deposits, with a shorter onset time (pain can be relieved after one treatment) and shorter treatment period than traditional external preparations. At the same time, the ingenious combination of Baishao and Chishao enhances the effect of removing blood stasis and dredging collaterals, and promoting the excretion of urate, while effectively reducing the irritation to the skin of sensitive joints in the acute phase of gout, with better safety, fully meeting the external treatment needs of acute and chronic gout.

[0055] Obviously, the above examples are only examples for clearly illustrating but not limiting the embodiments. Based on the above description, other different forms of changes or variations can be made by those skilled in the art. Here, all the embodiments are not required to be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. The application of a topical medicinal wine in the preparation of a medicine for treating gout, characterized in that, The external medicinal wine contains the following components in parts by weight: The ingredients are: 10-70 parts of dragon's blood, 10-70 parts of ephedra, 10-70 parts of cinnamon twig, 10-70 parts of safflower, 10-70 parts of chuanxiong rhizome, 10-70 parts of red peony root, 10-70 parts of white peony root, 10-70 parts of luffa fruit, 10-70 parts of tribulus terrestris, 10-70 parts of forsythia, 10-70 parts of white-flowered snake grass, 60-120 parts of angelica pubescens root, 60-120 parts of notopterygium root, 60-120 parts of salvia miltiorrhiza root, and 40,000-60,000 parts of baijiu (Chinese white liquor); the alcohol content of the baijiu is 60-80%.

2. The application of the external medicinal wine according to claim 1 in the preparation of a medicine for treating gout, characterized in that, The external medicinal wine is prepared through the following steps: (1) Dry each Chinese herbal medicine component to a moisture content of ≤8%, and then pulverize it. Then put it into a three-dimensional motion mixer to mix and obtain a uniformly mixed Chinese herbal medicine powder. (2) Add 5-8% of the weight of the mixed Chinese herbal powder to the white wine, stir evenly, and then place it in a vacuum drying oven for activation treatment; (3) Add the activated mixed Chinese medicine powder into the remaining white wine, seal the lid, soak for 7 days, filter out the dregs, and obtain the external medicinal wine.

3. The application of the external medicinal wine according to claim 2 in the preparation of a medicine for treating gout, characterized in that, The specific pulverization process described in step (1) is as follows: pulverize Angelica pubescens, Notopterygium incisum, and Salvia miltiorrhiza to 100-120 mesh; pulverize Dragon's Blood, Ephedra sinica, Cinnamomum cassia, Carthamus tinctorius, Ligusticum chuanxiong, Paeonia lactiflora, Paeonia veitchii, Liquidambar formosana, and Tribulus terrestris to 120-150 mesh; and pulverize Forsythia suspensa and Hedyotis diffusa to 150-200 mesh.

4. The application of the external medicinal wine according to claim 2 in the preparation of a medicine for treating gout, characterized in that, The mixing speed in step (1) is 30~50 r / min, and the mixing time is 15~20 min.

5. The application of the external medicinal wine according to claim 2 in the preparation of a medicine for treating gout, characterized in that, The activation process described in step (2) specifically includes: Treat for 2-3 hours under vacuum conditions of -0.06 to -0.08 MPa and temperature of 40 to 45°C.

6. The application of the external medicinal wine according to claim 1 in the preparation of a medicine for treating gout, characterized in that, Place the topical medicated wine in a container and ignite it. Dip the palm of your hand (wearing protective gear) into the ignited topical medicated wine and apply it to the affected area of ​​the body.

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