Soluble microneedle
By using sodium hyaluronate and trehalose of specific molecular weights in soluble microneedles, combined with a photocurable resin substrate and a low molecular weight polyvinylpyrrolidone penetration enhancer, the problems of insufficient permeability and bonding strength in existing technologies have been solved, achieving a balance between high permeability and low needle breakage rate, thus improving product quality and preparation efficiency.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEIJING CAS MICRONEEDLE TECH LTD
- Filing Date
- 2026-01-29
- Publication Date
- 2026-05-26
AI Technical Summary
Existing soluble microneedles have room for improvement in terms of cumulative permeability and the binding strength between the drug-loaded needle and the substrate, making it difficult to achieve both high permeability and low needle breakage rate.
A drug-loaded needle containing sodium hyaluronate and trehalose of a specific molecular weight is used, combined with a specific photocurable resin substrate. The substrate is formed by photocurable resin monomers, photoinitiators and solvents. The mass ratio and component ratio of the drug-loaded needle to the substrate are controlled. Low molecular weight polyvinylpyrrolidone and surfactants are used as penetration enhancers. The preparation process is optimized to improve the bonding strength and permeability.
It significantly improved the cumulative penetration rate of active drugs, reduced the needle breakage rate, enhanced the interfacial bonding strength between the drug-loaded needle and the substrate, simplified the preparation process, and improved the product qualification rate.
Smart Images
Figure CN121588023B_ABST