Compounds and compositions as CBP / p300 degradation agents and uses thereof

Abstract

Described herein are compounds of Formula I and pharmaceutically acceptable salts, solvates or stereoisomers thereof, as well as uses thereof (e.g., for degrading certain proteins, such as CBP / p300 protein).

Description

Related applications

[0001] This application claims the benefit and priority of U.S. Provisional Application No. 63 / 505,201, filed May 31, 2023, and U.S. Provisional Application No. 63 / 519,002, filed August 11, 2023, the contents of each of which are incorporated herein by reference in their entirety. Background Technology

[0002] Proteolytic targeting chimeric molecules (PROTACs) are heterobifunctional compounds that simultaneously bind to a target protein and an E3 ligase complex, inducing ubiquitin translocation and initiating a process that ultimately leads to proteasomal degradation of the target protein. PROTACs can generate enhanced substrate specificity by catalyzing the formation of a ternary complex involving the E3 ligase receptor, the target protein, and a small molecule. Selective PROTAC molecules have been in demand for the treatment and / or prevention of cancers and other diseases responding to inhibition or degradation of CBP / p300 proteins. Selective p300 degraders can exhibit strong selectivity for p300 beyond CBP and have demonstrated time-dependent loss of p300, enhancer acetylation, and transcriptional output in cancer cells both in vitro and in vivo, while exhibiting limited toxicity to untransformed cells. Enhanced p300 dependence has been found in many cancer lineages. Summary of the Invention

[0003] In some respects, this disclosure provides compounds of formula I: TLC(I), and its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: C has the formula I-1' (I-1') T has: i) Formula I-3-i (I-3-i) ii) Formula I-3-ii (I-3-ii) iii) Equation I-3-iii (I-3-iii) iv) Formula I-3-iv (I-3-iv) v) Equation I-3-v (I-3-v) or vi) Formula I-3-vi (I-3-vi), and L has the formula I-2'' (I-2'') Each of the variables in equations I-1', I-2', I-3-i, I-3-ii, I-3-iii, I-3-iv, I-3-v and I-3-vi is described, embodied and exemplified herein.

[0004] In some respects, this disclosure provides pharmaceutical compositions comprising the compounds disclosed herein and pharmaceutically acceptable excipients.

[0005] In some aspects, this disclosure provides a method for degrading proteins in a subject or biological sample, the method comprising administering a compound disclosed herein to the subject, or contacting the biological sample with a compound disclosed herein.

[0006] In some respects, this disclosure provides for the use of the compounds disclosed herein in the preparation of medicaments for the degradation of proteins in subjects or biological samples.

[0007] In some respects, this disclosure provides compounds disclosed herein for the degradation of proteins in subjects or biological samples. Detailed Implementation

[0008] This disclosure relates to compounds exhibiting activity in degrading certain proteins (e.g., p300 / CBP), and pharmaceutical compositions comprising such compounds.

[0009] The compounds disclosed herein In some respects, this disclosure provides compounds of formula I: TLC(I), and its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: C has the formula I-1' (I-1') in: Indicates connection to L; B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B6 It is C or N; R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is O, S, or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2. T has: i) Formula I-3-i (I-3-i) in: E 1 yes CR E1 Or N; E 2 yes CR E2 Or N; E 3 yes CR E3 Or N; Indicates connection to L; R E1 R E2 RE3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 1 It is C or N; F 2 It is NR F2' or CR F2; R F2' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b-OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 3 It is CR F3 , N or NR F3' ; R F3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c Rd -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F3' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F4 It is -C(=O)NR 3a R 3b Or optionally by one or more R u The substituted 5- to 6-membered heteroaryl groups; and R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R dThe alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl group, wherein the heterocycle or heteroaryl group is optionally connected by one or more R groups. u replace; ii) Formula I-3-ii (I-3-ii) in: G 1 yes , N or CR G1 ; G 2 yes , N or CR G2 ; G 3 yes , N or CR G3 ; Indicates connection to L; R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR bC(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; H 1 It is C(R) H1 2. NR H1' Or O; H 2 It is C(R) H2 2. NR H2' Or O; R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u Replace; and R H1' and R H2' Independently, it is hydrogen and C1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace, iii) Equation I-3-iii (I-3-iii) in: Indicates connection to L; I 1 It is C(R) I1 2. NR I1' Or O; I 2 It is C(R) I2 2. NR I2' Or O; R I1 and R I2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a-S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R I Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR bor -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; i is an integer selected from 0 to 4; J 1 Is it N or CR? J1 ; J 2 Is it N or CR? J2 ;and R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR cR d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; iv) Formula I-3-iv (I-3-iv) in: M 1 It is N or C; M 2 yes , , N or CR M2 ; M 3 yes , , N or CR M3 ; M 4 yes , , N or CR M4 ; in Indicates connection with L; and M 1 M 2 M 3 and M 4 At least one of them is N or ; R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR cS(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; K 1 Is it -C(=O)- or -C(R)? K1 )2-; Each R K1Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c Rd -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and k is an integer selected from 0 to 4; v) Equation I-3-v (I-3-v) in: P 1 yes , , N or CR P1 ; P 2 yes , , N or CR P2 ; Indicates connection to L; Each R N Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a-NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; n is an integer selected from 0 to 6; R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b-OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and R 4 It is -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; or vi) Formula I-3-vi (I-3-vi) in: Q 1 It is NR Q1' C(R) Q1 )2 or O; R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R dThe alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R Q1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q1 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; when If it is a double bond, then Q 2 Is it N or CR? Q2 And Q 3 Is it N or CR? Q3 ; when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O; Q 3 It is NR Q3' C(R) Q3 )2 or O; R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R dThe alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; S 1 It is CR S1 Or N; S 2 yes CR S2 Or N; S 3 yes CR S3 Or N; S 4 yes CR S4 Or N; Indicates connection with L; and R S1 R S2 R S3 and R S4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a-S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; L has the formula I-2'' (I-2'') in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes , in: when When it is a double bond, then Y 1 It is C; when When it is a single bond, then Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1 Or N; Z 2 It is CR Z2 Or N; R Z1 and R Z2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2It is a C6 arylene or a 5- to 6-membered heteroarylene, wherein the arylene or heteroarylene is optionally surrounded by one or more R u replace; L 2 It is CH2 or CH(C) 1-3 Alkyl); and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace, in: Each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 6-membered heterocyclic groups Each R a C is independent 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; Each R b Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; and Each R c and R d Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; or R c and R d Together with the nitrogen atom it is attached to, it forms a 3- to 6-membered heterocyclic group. Where R a R b R c and R d Each time it appears, it is independently and optionally controlled by one or more R... z Replace; and Each R z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbon cyclic groups or 3- to 6-membered heterocyclic groups.

[0010] In some respects, this disclosure provides compounds of formula I: TLC(I), and its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: C has the formula I-1' (I-1') in: Indicates connection to L; B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B 6 It is C or N; R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is either O or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2. T has: i) Formula I-3-i (I-3-i) in: E 1 yes CR E1 Or N; E 2 yes CR E2 Or N; E 3 yes CR E3 Or N; Indicates connection to L; R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NRc R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 1 It is C or N; F 2 It is NR F2' or CR F2 ; R F2' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c Rd -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 3 It is CR F3 , N or NR F3' ; R F3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR cS(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F3' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F4 It is -C(=O)NR 3a R 3bOr optionally by one or more R u The substituted 5- to 6-membered heteroaryl groups; and R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl group, wherein the heterocycle or heteroaryl group is optionally connected by one or more R groups. u replace; ii) Formula I-3-ii (I-3-ii) in: G 1 yes , N or CR G1 ; G 2 yes , N or CR G2 ; G 3 yes , N or CR G3 ; Indicates connection to L; R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; H 1 It is C(R) H1 2. NR H1' Or O; H 2 It is C(R) H2 2. NR H2' Or O; R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u Replace; and R H1' and R H2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace, iii) Equation I-3-iii (I-3-iii) in: Indicates connection to L; I 1 It is C(R) I1 2. NR I1' Or O; I 2 It is C(R) I2 2. NR I2' Or O; R I1 and R I2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R I Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c Rd -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; i is an integer selected from 0 to 4; J 1 Is it N or CR? J1 ; J 2 Is it N or CR? J2 ;and R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR cS(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; iv) Formula I-3-iv (I-3-iv) in: M 1 It is N or C; M 2 yes , , N or CR M2 ; M 3 yes , , N or CR M3 ; M 4 yes , , N or CR M4 ; in Indicates connection with L; and M 1 M 2 M 3 and M 4 At least one of them is N or ; R M2 R M3 and RM4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; K 1 Is it -C(=O)- or -C(R)? K1 )2-; Each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2ORb -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and k is an integer selected from 0 to 4; v) Equation I-3-v (I-3-v) in: P 1 yes , , N or CR P1 ; P 2 yes , , N or CR P2 ; Indicates connection to L; Each R N Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)Ra -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; n is an integer selected from 0 to 6; R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a-S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and R 4 It is -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; or vi) Formula I-3-vi (I-3-vi) in: Q 1 It is NR Q1' C(R) Q1 )2 or O; R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R Q1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q1 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; when If it is a double bond, then Q 2 Is it N or CR? Q2 And Q 3 Is it N or CR? Q3 ; when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O; Q 3 It is NR Q3' C(R) Q3)2 or O; R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; S 1 It is CR S1 Or N; S 2 yes CR S2 Or N; S 3 yes CR S3 Or N; S 4 yes CR S4 Or N; Indicates connection with L; and R S1 R S2 R S3 and R S4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; L has formula I-2' (I-2') in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes , in: Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1 Or N; R Z1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is optionally controlled by one or more R u Replaced 5- to 6-membered heteroaryl groups; L 2 It is CH2 or CH(C) 1-3 Alkyl); and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace, in: Each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups. Each R a C is independent 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; Each R b Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; and Each R c and R d Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; or R c and R d Together with the nitrogen atom it is attached to, it forms a 3- to 6-membered heterocyclic group. Where R a R b R c and R d Each time it appears, it is independently and optionally controlled by one or more R... z Replace; and Each R z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbon cyclic groups or 3- to 6-membered heterocyclic groups.

[0011] In some embodiments, this disclosure provides compounds of formula I: TLC(I), and its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: C has equation I-1 (I-1), in: B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; R B1 R B3 R B4 and R B5 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is either O or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; or When X is NR X And B 5 It is CR B5 When, then R X and R B5 Together with the atoms it bonds to, it forms a 5-membered heteroaryl group; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2. T has: i) Formula I-3-i (I-3-i) in: E 1 yes CR E1 Or N; E 2 yes CR E2 Or N; E 3 yes CR E3 Or N; Indicates connection to L; R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c Rd -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 1 It is C or N; F 2 It is NR F2' or CR F2 ; R F2' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 3 It is CR F3 , N or NR F3' ; R F3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F3' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)Ra -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F4 It is -C(=O)NR 3a R 3b Or optionally by one or more R u The substituted 5- to 6-membered heteroaryl groups; and R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl group, wherein the heterocycle or heteroaryl group is optionally connected by one or more R groups. u replace; ii) Formula I-3-ii (I-3-ii) in: G 1 yes , N or CR G1 ; G 2 yes , N or CR G2 ; G 3 yes , N or CR G3 ; Indicates connection to L; R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; H 1 It is C(R) H12. NR H1' Or O; H 2 It is C(R) H2 2. NR H2' Or O; R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u Replace; and R H1' and R H2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace, iii) Equation I-3-iii (I-3-iii) in: Indicates connection to L; I 1 It is C(R) I1 2. NR I1' Or O; I 2 It is C(R) I22. NR I2' Or O; R I1 and R I2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R I Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b-S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; i is an integer selected from 0 to 4; J 1 Is it N or CR? J1 ; J 2 Is it N or CR? J2 ;and R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b-S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; iv) Formula I-3-iv (I-3-iv) in: M 1 It is N or C; M 2 yes , , N or CR M2 ; M 3 yes , , N or CR M3 ; M 4 yes , , N or CR M4 ; in Indicates connection with L; and M 1 M 2 M 3 and M 4 At least one of them is N or ; R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NRc R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; K 1 Is it -C(=O)- or -C(R)? K1 )2-; Each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a-S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and k is an integer selected from 0 to 4; v) Equation I-3-v (I-3-v) in: P 1 yes , , N or CR P1 ; P 2 yes , , N or CR P2 ; Indicates connection to L; Each R NIndependently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; n is an integer selected from 0 to 6; R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and R 4 It is -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; or vi) Formula I-3-vi (I-3-vi) in: Q 1 It is NR Q1' C(R) Q1 )2 or O; R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R Q1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q1 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; when If it is a double bond, then Q 2 Is it N or CR? Q2 And Q 3 Is it N or CR? Q3 ; when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O; Q 3 It is NR Q3' C(R) Q3 )2 or O; R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; S1 It is CR S1 Or N; S 2 yes CR S2 Or N; S 3 yes CR S3 Or N; S 4 yes CR S4 Or N; Indicates connection with L; and R S1 R S2 R S3 and R S4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a-OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; L has Equation I-2 (I-2) in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, t is an integer selected from 0 to 6; or Cy1 yes , in: Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1 Or N; R Z1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is optionally controlled by one or more R u The 5- to 6-membered heteroaryl groups are replaced; and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace, in: Each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups. Each R a C is independent 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; Each R b Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; and Each R c and R d Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; or R c and R d Together with the nitrogen atom it is attached to, it forms a 3- to 6-membered heterocyclic group. Where R aR b R c and R d Each time it appears, it is independently and optionally controlled by one or more R... z Replace; and Each R z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbon cyclic groups or 3- to 6-membered heterocyclic groups.

[0012] In some embodiments, this disclosure provides compounds of formula IA: (IA), Or its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: G 3 It is N or CH; R G4 It is C 1-6 Alkyl or 3- to 12-membered heterocyclic groups; Cy 1 yes or , in: Indicates connection to ring G; Z 1 It is CR Z1 Or N; R Z1 It is halogen; and Cy 2 yes or ,in Indicates Cy 1 connect.

[0013] In some embodiments, this disclosure provides compounds of formula IB: (IB), Or its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: S 1 It is CH or N; S 3 It is CH or N; and R S2 It is C 1-6 Alkyl or 3- to 12-membered heterocyclic groups.

[0014] In some embodiments, the compound of formula I is not and / or .

[0015] In some embodiments, the compound of formula I is not , , , and / or .

[0016] In some embodiments, C has formula I-1' (I-1') in: Indicates connection to L; B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B 6 It is C or N; R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is O, S, or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R DIndependently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2.

[0017] In some embodiments, C has formula I-1' (I-1') in: Indicates connection to L; B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B 6 It is C or N; R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is either O or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2.

[0018] In some embodiments, C has formula I-1', wherein: B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B 6 It is C or N; R B1 It is hydrogen or halogen; R B3 It is hydrogen, halogen, -CN or C 1-6 alkyl; R B4 It is hydrogen, halogen, -CN, C 1-6 Alkyl, C 1-6 Alkylamino or 3- to 4-membered heterocyclic groups; R B5 It is a C that is oxidized, hydrogenated, halogenated, or optionally substituted with one or more halogens. 1-6 Alkyl groups, C groups optionally substituted with one or more halogens 1-6 Alkoxy or C 1-6 Alkylamino.

[0019] X does not exist; it is either O or NR. X ; R X Is it hydrogen or C? 1-3 alkyl; R D1 It is hydrogen; d is 0; and q is 1.

[0020] In some embodiments, C has formula I-1 (I-1), in: B1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; R B1 R B3 R B4 and R B5 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is either O or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; or When X is NR X And B 5 It is CR B5 When, then R X and R B5 Together with the atoms it bonds to, it forms a 5-membered heteroaryl group; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2.

[0021] In some embodiments, C has formula I-1' (I-1') in: Indicates connection to L; B 1 It is CR B1 ; B 3 It is CR B3 ; B 4 It is CR B4 ; B 5 It is CR B5 ; B 6 It is C; R B1 R B3 R B4 and R B5 It is hydrogen on its own; X is NR X ; R X It is hydrogen; R D1 It is hydrogen; d is 0; and q is 1.

[0022] In some embodiments, X is absent and is O, S, or NR. X In some embodiments, X is 0. In some embodiments, X is S. In some embodiments, X is NR. X .

[0023] In some embodiments, X is absent, and is O or NR. X In some embodiments, X is absent or NH. In some embodiments, X is absent.

[0024] In some embodiments, R X It is hydrogen, C 1-3 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), or isopropyl (C3)), C 3-4 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4) or cyclobutenyl (C4)) or 3- to 4-membered heterocyclic groups (e.g., heterocyclic groups comprising a 3- to 4-membered ring and a heteroatom selected from N, O and S).

[0025] In some embodiments, C has the formula I-1'-X or I-1'-Y. (I-1'-X) or (I-1'-Y) In some embodiments, C has formula I-1-i, I-1-ii, or I-1-iii. (I-1-i) (I-1-ii) or (I-1-iii).

[0026] In some embodiments, C has the formula I-1-i (I-1-i).

[0027] In certain embodiments, C has the formula I-1-i-1', I-1-i-2', I-1-i-3, I-1-ii-1, I-1-ii-2, I-1-ii-3, I-1-iii-1, I-1-iii-2, or I-1-iii-3 (I-1-i-1') (I-1-i-2') (I-1-i-3) (I-1-ii-1) (I-1-ii-2) (I-1-ii-3) (I-1-iii-1) (I-1-iii-2) or (I-1-iii-3).

[0028] In some embodiments, C has the formula I-1-i-1 or I-1-i-2. (I-1-i-1) or (I-1-i-2).

[0029] In some embodiments, B 1 It is CR B1 Or N. In some embodiments, B 1 It is CR B1 In some embodiments, B 1 It is N.

[0030] In some embodiments, B 3 It is CR B3 Or N. In some embodiments, B 3 It is CR B3 In some embodiments, B 3 It is N.

[0031] In some embodiments, B 4 It is CR B4 Or N. In some embodiments, B 4 It is CR B4 In some embodiments, B4 It is N.

[0032] In some embodiments, B 5 It is CR B5 Or N. In some embodiments, B 5 It is CR B5 In some embodiments, B 5 It is N.

[0033] In some embodiments, B 6 It is C or N. In some embodiments, B 6 It is C. In some embodiments, B 6 It is N.

[0034] In some embodiments, B 1 B 3 B 4 and B 5 None of them are N.

[0035] In some embodiments, B 1 and B 5 One of them is N, and B 1 and B 5 The other one is CR B1 or CR B5 .

[0036] In some embodiments, R B1 R B3 R B4 and R B5 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 5-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0037] In some embodiments, R B1 R B3 and R B4 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 5-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0038] In some embodiments, R B3 R B4 and R B5 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 5-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 5-membered ring and at least one heteroatom independently selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0039] In some embodiments, R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 or R B3 R B4 and R B5 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0040] In some embodiments, R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbon cyclic group or 3- to 5-membered heterocyclic group.

[0041] In some embodiments, R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbon cyclic group or 3- to 4-membered heterocyclic group.

[0042] In some embodiments, R B1 R B3 R B4 and R B5Independently, it consists of oxygen, hydrogen, halogen, and carbon. 1-6 Alkyl or C 1-6 Alkyl group.

[0043] In some embodiments, R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 or R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally substituted with one or more halogens.

[0044] In some embodiments, R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally substituted with one or more halogens.

[0045] In some embodiments, R B1 R B3 and R B4 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally substituted with one or more halogens.

[0046] In some embodiments, R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally substituted with one or more halogens.

[0047] In some embodiments, R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 or R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally substituted with one or more halogens.

[0048] In some embodiments, R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 or R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -OH, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy or C 1-6 Alkylamino.

[0049] In some embodiments, R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 or R B3 R B4 and R B5 Independently, it is hydrogen, halogen, or C. 1-6 alkyl.

[0050] In some embodiments, R D1 Is it hydrogen, deuterium, or carbon? 1-6Alkyl (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5) or hexyl (C6)).

[0051] In some embodiments, R D1 It is hydrogen.

[0052] In some embodiments, each R D Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is used. In some embodiments, d is an integer from 0 to 6 when valence is allowed. In some embodiments, d is 0. In some embodiments, d is 1. In some embodiments, d is 2. In some embodiments, d is 3 when valence is allowed. In some embodiments, d is 4 when valence is allowed. In some embodiments, d is 5 when valence is allowed. In some embodiments, d is 6 when valence is allowed.

[0053] In some embodiments, d is 0.

[0054] In some embodiments, q is an integer from 0 to 2. In some embodiments, q is 0. In some embodiments, q is 1. In some embodiments, q is 2.

[0055] In some embodiments, q is 1.

[0056] In some embodiments, C is selected from the group consisting of: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and .

[0057] In some embodiments, C is or .

[0058] In some embodiments, T is Equation I-3-i (I-3-i) in: E 1 yes CR E1 Or N; E 2 yes CR E2 Or N; E 3 yes CR E3 Or N; Indicates connection to L; R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b-OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 1 It is C or N; F 2 It is NR F2' or CR F2 ; R F2' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2Ra -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 3 It is CR F3 , N or NR F3' ; R F3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2ORb -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F3' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F4 It is -C(=O)NR 3a R 3b Or optionally by one or more R u The substituted 5- to 6-membered heteroaryl groups; and R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl group, wherein the heterocycle or heteroaryl group is optionally connected by one or more R groups. u replace.

[0059] In some embodiments, T has the formula I-3-ia (I-3-ia).

[0060] In some embodiments, T has the formula I-3-ib (I-3-ib).

[0061] In some embodiments, E 1 yes CR E1 Or N.

[0062] In some embodiments, E 2 yes CR E2 Or N.

[0063] In some embodiments, E 3 yes CR E3 Or N.

[0064] In some embodiments, E 1 E 2 and E 3 One of them is N. In some embodiments, E 1 E 2 and E 3 The two in it are N.

[0065] In some embodiments, R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d-OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0066] In some embodiments, R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0067] In some embodiments, R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0068] In some embodiments, R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0069] In some embodiments, R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0070] In some embodiments, R E1 and R E3 Independently, or R E1 or R E2 It is hydrogen, halogen, or optionally contained by one or more R u Replacement C 1-6 alkyl.

[0071] In some embodiments, R E4 It is hydrogen, halogen, -CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, or -S(=O)2R a The alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0072] In some embodiments, F 1 It is C or N.

[0073] In some embodiments, F 2 It is NR F2' or CR F2 .

[0074] In some embodiments, F 3 It is NR F3' , N or CR F3 .

[0075] In some embodiments, R F2' and R F3' Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2)), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5) or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0076] In some embodiments, R F2' and R F3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, 5- to 6-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0077] In some embodiments, R F2' and R F3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0078] In some embodiments, R F2' and R F3' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R dThe alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0079] In some embodiments, R F2' It is hydrogen or optionally composed of one or more R u Replacement C 1-6 alkyl.

[0080] In some embodiments, R F2 and R F3 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c Rd -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0081] In some embodiments, R F2 and R F3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0082] In some embodiments, R F2 and R F3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0083] In some embodiments, R F2 and R F3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0084] In some embodiments, R F2 and R F3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0085] In some embodiments, R F3 It is hydrogen.

[0086] In some embodiments, R F4 It is -C(=O)NR 3a R 3b Or optionally by one or more R u Substituted 5- to 6-membered heteroaryl groups (e.g., heteroaryl groups comprising a 5- or 6-membered ring and 1-3 heteroatoms selected from N, O, and S).

[0087] In some embodiments, R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2)), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5) or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0088] In some embodiments, R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, 5- to 6-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0089] In some embodiments, R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b-S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0090] In some embodiments, R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0091] In some embodiments, R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle (e.g., a heterocyclic group comprising one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S) or a 5- to 10-membered heteroaryl group (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the heterocycle or heteroaryl group is optionally connected by one or more R u replace.

[0092] In some embodiments, R 3a and R 3b Independently hydrogen or optionally by one or more R u Replacement C 1-6 alkyl.

[0093] In some embodiments, T has formula I-3-ii (I-3-ii) in: G 1 yes , N or CR G1 ; G 2 yes , N or CRG2 ; G 3 yes , N or CR G3 ; Indicates connection to L; R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R dThe alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; H 1 It is C(R) H1 2. NR H1' Or O; H 2 It is C(R) H2 2. NR H2' Or O; R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u Replace; and R H1' and R H2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0094] In some embodiments, T has formula I-3-ii (I-3-ii) in: G1 It is CR G1 ; G 2 yes ; G 3 Is it N or CR? G3 ; Indicates connection to L; R G1 R G3 and R G4 Independently, it is hydrogen and C 1-6 Alkyl or 3- to 12-membered heterocyclic groups; H 1 It is NR H1' ; H 2 It is NR H2' ;and R H1' and R H2' C is independent 1-6 alkyl.

[0095] In some embodiments, T has formula I-3-ii-a (I-3-ii-a).

[0096] In some embodiments, G 1 yes , N or CR G1 .

[0097] In some embodiments, G 2 yes , N or CR G2 .

[0098] In some embodiments, G 3 yes , N or CR G3 .

[0099] In some embodiments, R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0100] In some embodiments, R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0101] In some embodiments, R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0102] In some embodiments, R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0103] In some embodiments, R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0104] In some embodiments, R G1 and R G3 Both are hydrogen.

[0105] In some embodiments, R G4 It is hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenyl or 3- to 12-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl or heterocyclic group is optionally surrounded by one or more R u replace.

[0106] In some embodiments, R G4 It is C 1-6 Alkyl, C 1-6 Alkylamino and 3- to 12-membered heterocyclic groups, wherein the alkyl, alkylamino, or heterocyclic group is optionally surrounded by one or more R u replace.

[0107] In some embodiments, R G4 It is C 1-6 Alkyl, C 1-6 Alkylamino and 3- to 12-membered heterocyclic groups, wherein the alkyl, alkylamino, or heterocyclic group is optionally surrounded by one or more -OH, halogen, and C. 1-6 Alkyl substitution.

[0108] In some embodiments, H 1 It is C(R) H1 2. NR H1' Or O.

[0109] In some embodiments, H 2 It is C(R) H2 2. NR H2' Or O.

[0110] In some embodiments, H 1 It is NR H1' And H 2 It is NR H2' .

[0111] In some embodiments, R H1 and R H2 Each time it appears, it is independently hydrogen, a halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H-Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl) or 5- to 10-membered heteroaryl (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R u replace.

[0112] In some embodiments, R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0113] In some embodiments, R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0114] In some embodiments, R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0115] In some embodiments, R H1' and R H2' C is independent 1-6 alkyl.

[0116] In some embodiments, R H1' and R H2' Independently hydrogen or C 1-6 alkyl.

[0117] In some embodiments, two R H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic group is optionally separated by one or more R atoms. u replace.

[0118] In some embodiments, R H1' and R H2' Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)), 3- to 6-membered heterocyclic groups (e.g., heterocyclic groups comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. ureplace.

[0119] In certain embodiments, T has formula I-3-ii-a-1, I-3-ii-a-2, I-3-ii-a-3, I-3-ii-a-4, or I-3-ii-a-5 (I-3-ii-a-1) (I-3-ii-a-2) (I-3-ii-a-3), (I-3-ii-a-4) or (I-3-ii-a-5).

[0120] In some embodiments, T is selected from the group consisting of: , , , , , , , , , , , , , and .

[0121] In some embodiments, T has formula I-3-iii (I-3-iii) in: Indicates connection to L; I 1 It is C(R) I1 2. NR I1' Or O; I 2 It is C(R) I2 2. NR I2' Or O; R I1 and R I2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R I Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NRc R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; i is an integer selected from 0 to 4; J 1 Is it N or CR? J1 ; J 2 Is it N or CR? J2 ;and R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR cS(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0122] In some embodiments, T has formula I-3-iii-a (I-3-iii-a).

[0123] In some embodiments, I 1 It is C(R) I1 2. NR I1' Or O.

[0124] In some embodiments, I 2 It is C(R) I2 2. NR I2' Or O.

[0125] In some embodiments, I 1 It is NR I1' And I 2 It is NR I2'。

[0126] In some embodiments, R I1 and R I2 Each time it appears, it is independently an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H-Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl) or 5- to 10-membered heteroaryl (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R u replace.

[0127] In some embodiments, R I1 and R I2 Each time it appears, it is independently of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0128] In some embodiments, R I1 and R I2 Each time it appears, it is independently of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0129] In some embodiments, R I1 and R I2 Each time it appears, it is independently of oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0130] In some embodiments, two R I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic group is optionally separated by one or more R atoms. u replace; In some embodiments, R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)), 3- to 6-membered heterocyclic groups (e.g., heterocyclic groups comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0131] In some embodiments, R I1' and R I2' Independently hydrogen or C 1-6 alkyl.

[0132] In some embodiments, each R IIndependently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d-C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0133] In some embodiments, each R I Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0134] In some embodiments, each R I Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0135] In some embodiments, each R I Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0136] In some embodiments, each R I It is C1-6 Alkyl group. In some embodiments, at least one R I It is C 1-6 alkyl.

[0137] In some embodiments, each R I Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0138] In some embodiments, i is an integer selected from 0 to 4. In some embodiments, i is 0. In some embodiments, i is 1. In some embodiments, i is 2. In some embodiments, i is 3. In some embodiments, i is 4.

[0139] In some embodiments, J 1 Is it N or CR? J1 .

[0140] In some embodiments, J 2 Is it N or CR? J2 .

[0141] In some embodiments, R J1 R J2 and R J3 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)Ra -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0142] In some embodiments, R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0143] In some embodiments, R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0144] In some embodiments, R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0145] In some embodiments, R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0146] In some embodiments, R J3 It is hydrogen, halogen, C 1-6 Alkyl, 3- to 12-membered heterocyclic, 5- to 10-membered heteroaryl, or -C(=O)NR c R d The alkyl, heterocyclic, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0147] In some embodiments, R J1 and R J2 Independently hydrogen or optionally by one or more R u Replacement C 1-6 alkyl.

[0148] In some embodiments, T has formula I-3-iv (I-3-iv) in: M 1 It is N or C; M 2 yes , , N or CR M2 ; M 3 yes , , N or CR M3 ; M 4 yes , , N or CR M4 ; in Indicates connection with L; and M 1 M 2 M 3 and M 4 At least one of them is N or ; R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2ORb -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; K 1 Is it -C(=O)- or -C(R)? K1 )2-; Each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NRc R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and k is an integer selected from 0 to 4.

[0149] In some embodiments, T has formula I-3-iv-a (I-3-iv-a).

[0150] In some embodiments, T has formula I-3-iv-b (I-3-iv-b).

[0151] In some embodiments, M 1 It is N or C.

[0152] In some embodiments, M 2 yes , , N or CR M2 .

[0153] In some embodiments, M 3 yes , , N or CR M3 .

[0154] In some embodiments, M 3 It is N.

[0155] In some embodiments, M 4 yes , , N or CR M4 .

[0156] In some embodiments, M 1 M 2 M 3 and M 4 At least one of them is N or .

[0157] In some embodiments, M 1 M 3 and M 4 At least two of them are N. In some embodiments, M 1 M 3 and M 4 At least one of them is N.

[0158] In some embodiments, R M2 R M3 and RM4 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d-C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0159] In some embodiments, R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0160] In some embodiments, R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0161] In some embodiments, R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0162] In some embodiments, R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0163] In some embodiments, R M2 It is C 1-6 Alkyl, C 1-6 Alkoxy or 3- to 12-membered heterocyclic group, wherein the alkyl, alkoxy, or heterocyclic group is optionally surrounded by one or more R u replace.

[0164] In some embodiments, R M3 It is hydrogen.

[0165] In some embodiments, R K' It is hydrogen, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2)), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5) or hexynyl (C6)), C 3-12Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0166] In some embodiments, R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, 5- to 6-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0167] In some embodiments, R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0168] In some embodiments, R K' It is hydrogen, C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0169] In some embodiments, R K' It is hydrogen or optionally composed of one or more R u Replacement C 1-6 alkyl.

[0170] In some embodiments, K 1 Is it -C(=O)- or -C(R)? K1 )2-.

[0171] In some embodiments, each R K1 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl) or 5- to 10-membered heteroaryl (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R u replace.

[0172] In some embodiments, each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0173] In some embodiments, each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0174] In some embodiments, each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0175] In some embodiments, each R KIndependently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d-C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0176] In some embodiments, each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0177] In some embodiments, each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0178] In some embodiments, each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0179] In some embodiments, each R KIndependently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0180] In some embodiments, each R K Independently hydrogen or C 1-6 Alkyl group. In some embodiments, at least one R K It is hydrogen. In some embodiments, at least one R K It is C 1-6 alkyl.

[0181] In some embodiments, an R K It's hydrogen, the other paired R K It is C 1-6 alkyl.

[0182] In some embodiments, k is an integer selected from 0 to 4. In some embodiments, k is 0. In some embodiments, k is 1. In some embodiments, k is 2. In some embodiments, k is 3. In some embodiments, k is 4.

[0183] In some embodiments, T has formula I-3-iv-a-1 (I-3-iv-a-1).

[0184] In some embodiments, T is .

[0185] In some embodiments, T has formula I-3-v (I-3-v) in: P 1 yes , , N or CR P1 ; P 2 yes , , N or CR P2 ; Indicates connection to L; Each R N Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; n is an integer selected from 0 to 6; R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and R 4 It is -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0186] In some embodiments, T has the formula I-3-va (I-3-va).

[0187] In some embodiments, P 1 yes , , N or CR P1 .

[0188] In some embodiments, P 2 yes , , N or CR P2 .

[0189] In some embodiments, each R N Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)Ra -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0190] In some embodiments, each R N Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0191] In some embodiments, each R N Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0192] In some embodiments, each R N Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0193] In some embodiments, each R N Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0194] In some embodiments, n is an integer selected from 0 to 6. In some embodiments, n is 0. In some embodiments, n is 1. In some embodiments, n is 2. In some embodiments, n is 3. In some embodiments, n is 4. In some embodiments, n is 5. In some embodiments, n is 6.

[0195] In some embodiments, n is 0.

[0196] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0197] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H-Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0198] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0199] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0200] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0201] In some embodiments, R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups.u replace.

[0202] In some embodiments, R P3 It is hydrogen, C 1-6 Alkyl, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0203] In some embodiments, R 4 It is -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0204] In some embodiments, R 4 It is C 1-6 Alkyl or C 1-6 Alkylamino, wherein the alkyl or alkylamino group is optionally composed of one or more R u replace.

[0205] In some embodiments, T has formula I-3-vi , in: Q 1 It is NR Q1' C(R) Q1 )2 or O; R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)Ra -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R Q1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q1 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; when If it is a double bond, then Q 2 Is it N or CR? Q2 And Q 3 Is it N or CR? Q3 ; when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O; Q 3 It is NR Q3' C(R) Q3 )2 or O; R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)ORb or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; S 1 It is CR S1 Or N; S 2 yes CR S2 Or N; S 3 yes CR S3 Or N; S 4 yes CR S4 Or N; Indicates connection with L; and R S1 R S2 R S3 and R S4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0206] In some embodiments, T has formula I-3-vi (I-3-vi) in: Q 1 It is NR Q1' ; R Q1' It is C 1-6 alkyl; It is a double bond; Q 2 It is CR Q2 ; Q3 It is CR Q3 ; R Q2 and R Q3 Each time it appears, it is independently either hydrogen or C. 1-6 alkyl; S 1 It is CR S1 Or N; S 2 It is CR S2 ; S 3 It is CR S3 Or N; S 4 yes ; Indicates connection with L; and R S1 R S2 and R S3 Independently, it is hydrogen and C 1-6 Alkyl or 3- to 12-membered heterocyclic groups.

[0207] In some embodiments, T has formula I-3-vi-a or I-3-vi-b (I-3-vi-a) or (I-3-vi-b).

[0208] In some embodiments, Q 1 It is NR Q1' C(R) Q1 )2 or O.

[0209] In some embodiments, R Q1' It is hydrogen, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2)), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5) or hexynyl (C6)), C 3-12Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0210] In some embodiments, R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, 5- to 6-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0211] In some embodiments, R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0212] In some embodiments, R Q1' It is hydrogen, C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0213] In some embodiments, R Q1' Is it hydrogen or C? 1-6 alkyl.

[0214] In some embodiments, each R Q1 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10Aryl (e.g., phenyl or naphthyl) or 5- to 10-membered heteroaryl (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R u replace.

[0215] In some embodiments, each R Q1 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0216] In some embodiments, each R Q1 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0217] In some embodiments, each R Q1 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0218] In some embodiments, two R Q1 Together with the carbon atom it is attached to, it forms C 3-6A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic group is optionally separated by one or more R atoms. u replace.

[0219] In some embodiments, when If it is a double bond, then Q 2 Is it N or CR? Q2 .

[0220] In some embodiments, when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O.

[0221] In some embodiments, R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2)), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5) or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9)10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0222] In some embodiments, R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, 5- to 6-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0223] In some embodiments, R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a-C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0224] In some embodiments, R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0225] In some embodiments, R Q2 and R Q3 Each time it appears, it is independently hydrogen, a halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10Aryl (e.g., phenyl or naphthyl) or 5- to 10-membered heteroaryl (e.g., a heteroaryl group comprising one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R u replace.

[0226] In some embodiments, R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0227] In some embodiments, R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0228] In some embodiments, R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0229] In some embodiments, each R Q2 It is hydrogen.

[0230] In some embodiments, two RQ2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 6-membered ring and 1-3 heteroatoms selected from N, O, and S), wherein the carbocyclic or heterocyclic group is optionally separated by one or more R atoms. u replace.

[0231] In some embodiments, S 1 It is CR S1 Or N.

[0232] In some embodiments, S 2 yes CR S2 Or N.

[0233] In some embodiments, S 3 yes CR S3 Or N.

[0234] In some embodiments, S 4 yes CR S4 Or N.

[0235] In some embodiments, R S1 R S2 R S3 and R S4 Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-isobutylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 2-6 Alkenyl (e.g., vinyl (C2), 1-propenyl (C3), 2-propenyl (C3), 1-butenyl (C4), 2-butenyl (C4), butadienyl (C4), pentenyl (C5), pentadienyl (C5), or hexenyl (C6)), C 2-6 Alkynyl (e.g., ethynyl (C2), 1-propynyl (C3), 2-propynyl (C3), 1-butynyl (C4), 2-butynyl (C4), pentynyl (C5), or hexynyl (C6)), C 3-12 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), cyclohexadienyl (C6), cycloheptyl (C7), cycloheptenyl (C7), cycloheptadienyl (C7), cycloheptanetrienyl (C7), cyclooctyl (C8), cyclooctenyl (C8), bicyclo[2.2.1]heptyl (C7), bicyclo[2.2.2]octyl (C8), cyclononyl (C9), cyclononenyl (C9), cyclodecyl (C9) 10 ), cyclodecenyl (C 10 ), Octahydro-1 H -Indanyl (C9), decahydronaphthyl (C9) 10 ) or spiro[4.5]decyl (C 10 ), 3- to 12-membered heterocyclic groups (e.g., heterocyclic groups containing one or two 3- to 8-membered rings and 1-5 heteroatoms selected from N, O, and S), C 6-10 Aryl (e.g., phenyl or naphthyl), 5- to 10-membered heteroaryl (e.g., heteroaryl containing one or two 5- or 6-membered rings and 1-5 heteroatoms selected from N, O, and S), -SR b -S(=O)Ra -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

[0236] In some embodiments, R S1 R S2 R S3 and R S4 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups.u replace.

[0237] In some embodiments, R S1 R S2 R S3 and R S4 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0238] In some embodiments, R S1 R S2 R S3 and R S4 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0239] In some embodiments, R S1 R S2 R S3 and R S4 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0240] In some embodiments, R S1 and R S3 Both are hydrogen.

[0241] In some embodiments, R S2 It is hydrogen, C1-6 Alkyl or C 1-6 Alkyl group.

[0242] In some embodiments, R S2 It is C 1-6 Alkyl, C 1-6 Alkoxy or C 3-12 A carbocyclic group, wherein the alkyl, alkoxy, or carbocyclic group is optionally surrounded by one or more R groups. u replace.

[0243] In some embodiments, R S2 It is C 1-6 Alkyl, C 1-6 Alkoxy or C 3-12 A carbocyclic group, wherein the alkyl, alkoxy, or carbocyclic group is optionally oxidized by one or more oxo, halogen, and C. 1-6 Alkyl substitution.

[0244] In some embodiments, R S4 Is it hydrogen or C? 1-6 alkyl.

[0245] In some embodiments, T has formula I-3-vi-a-1 or I-3-vi-a-2 (I-3-vi-a-1) or (I-3-vi-a-2).

[0246] In some embodiments, T has the formula I-3-vi-a-1-a, I-3-vi-a-1-b, I-3-vi-a-2-a, or I-3-vi-a-2-b (I-3-vi-a-1-a) (I-3-vi-a-1-b). (I-3-vi-a-2-a) or (I-3-vi-a-2-b).

[0247] In some embodiments, T is selected from the group consisting of: , , , , , , , , , , , , , , , , , , , , , and .

[0248] In some embodiments, T has formula I-3-ii, I-3-iv, or I-3-vi.

[0249] In some embodiments, L has formula I-2'' (I-2'') in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes , in: when When it is a double bond, then Y 1 It is C; when When it is a single bond, then Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d ; Z 1 It is CR Z1 Or N; Z 2 It is CR Z2 Or N; R Z1 and R Z2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is a C6 arylene or a 5- to 6-membered heteroarylene, wherein the arylene or heteroarylene is optionally surrounded by one or more R u replace; L 2 It is CH2 or CH(C) 1-3 Alkyl); and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace.

[0250] In some embodiments, L has formula I-2'' (I-2'') in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 ; V 1 It is N; V 2 It is CR V2 ; R T1 and R V2 It is hydrogen on its own; t is 0; or Cy 1 yes , in: It is a single key; Y 1 It is N; Indicates a connection to T; Y 2It is O; Z 1 It is CR Z1 Or N; Z 2 It is CR Z2 ; R Z1 and R Z2 It can be either hydrogen or halogen; z is 0, Cy 2 It is a 5- to 6-yuan heteroaryl group; L 2 It is CH2; and L 3 It is an ethynyl group.

[0251] In some embodiments, L has formula I-2' (I-2') in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes , in: Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1Or N; R Z1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is a 5- to 6-membered heteroaryl group, wherein the heteroaryl group is optionally surrounded by one or more R groups. u replace; L 2 It is CH2 or CH(C) 1-3 Alkyl); and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace.

[0252] In some embodiments, L has formula I-2 (I-2) in: Indicates a connection to C; Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes , in: Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1 Or N; R Z1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is a 5- to 6-yuan heteroaryl compound; and L 3 It is an E-vinylidene, ethynylene, C6-arylene, or 5- to 6-heteroarylene.

[0253] In some embodiments, L has the formula I-2-a'' (I-2-a'').

[0254] In some embodiments, Cy 1 yes , in: Indicates a connection to T; T 1 It is CR T1 ; V 1 It is N; V 2 It is CR V2 ; R T1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, t is an integer selected from 0 to 6.

[0255] In some embodiments, Cy 1 yes .

[0256] In some embodiments, T 1 It is CR T1 Or N. In some embodiments, T 1 It is CR T1 In some embodiments, T 1 It is N.

[0257] In some embodiments, V 1 It is CR V1 Or N. In some embodiments, V 1 It is CR V1 In some embodiments, V 2 It is N.

[0258] In some embodiments, V 2 It is CR V2 Or N. In some embodiments, V 2It is CR V2 In some embodiments, V 2 It is N.

[0259] In some embodiments, R T1 R V1 and R V2 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino, ethyl...) propyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0260] In some embodiments, R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 Carbocyclic, 3- to 6-membered heterocyclic, C6 aryl, or 5- to 6-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally represented by one or more R groups. u replace.

[0261] In some embodiments, R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0262] In some embodiments, R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 A carbocyclic or 3- to 6-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0263] In some embodiments, R T1 and R V2 Both are hydrogen.

[0264] In some embodiments, each R T Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0265] In some embodiments, each R T C is independent 1-6 Alkyl group. In some embodiments, at least one R T It is C 1-6 alkyl.

[0266] In some embodiments, t is 0. In some embodiments, t is 1. In some embodiments, t is 2. In some embodiments, t is 3. In some embodiments, t is 4. In some embodiments, t is 5. In some embodiments, t is 6.

[0267] In some embodiments, Cy 1 yes , in: Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Z 1 It is CR Z1 Or N; R Z1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic, 3- to 4-membered heterocyclic, wherein the alkyl, alkoxy, alkylamino, carbocyclic or heterocyclic group is optionally surrounded by one or more R u replace; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 4-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z.

[0268] In some embodiments, Cy 1 yes , in: when When it is a double bond, then Y 1 It is C; when When it is a single bond, then Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c Rd ; Z 1 It is CR Z1 Or N; Z 2 It is CR Z2 Or N; R Z1 and R Z2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z.

[0269] In some embodiments, Cy 1 yes , Where R Z1 It is a C that is replaced by one or more halogens. 1-6 alkyl.

[0270] In some embodiments, Cy 1 yes , , or .

[0271] In some embodiments, Cy 1 yes , , , , or .

[0272] In some embodiments, Y 1 Is it N or CR? Y1 In some embodiments, Y 1 It is N. In some embodiments, Y1 It is CR Y1 .

[0273] In some embodiments, Y 1 It's C.

[0274] In some embodiments, It is a single bond. In some embodiments, It is a double bond.

[0275] In some embodiments, R Y1 It is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0276] In some embodiments, Y 2It is C(R) Y2 )2, O or N(R) Y2' ).

[0277] In some embodiments, Y 2 It is CH2, O, or NMe.

[0278] In some embodiments, each R Y2 Independently, it is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6 Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0279] In some embodiments, each R Y2 It is hydrogen.

[0280] In some embodiments, RY2' It is hydrogen, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-4 Carbocyclic groups (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4), 3- to 4-membered heterocyclic groups (e.g., heterocyclic groups comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace.

[0281] In some embodiments, Z 1 It is CR Z1 Or N.

[0282] In some embodiments, R Z1 It is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Haloalkyl (C1-C2 substituted with one or more halogens, for example, one, two or three halogens) 1-6 Alkyl), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0283] In some embodiments, R Z1 It is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0284] In some embodiments, Z 2 It is CR Z2 Or N.

[0285] In some embodiments, R Z2 It is hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Haloalkyl (C1-C2 substituted with one or more halogens, for example, one, two or three halogens) 1-6 Alkyl), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0286] In some embodiments, each R Z Independently, it is an oxo, hydrogen, halogen (e.g., -F, -Cl, -Br or -I), -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising one or two 3- to 4-membered rings and one heteroatom selected from N, O, and S), wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0287] In some embodiments, at least one R Z It is oxygenation.

[0288] In some embodiments, z is 0. In some embodiments, z is 1. In some embodiments, z is 2 when valence is allowed. In some embodiments, z is 3 when valence is allowed. In some embodiments, z is 4 when valence is allowed. In some embodiments, z is 5 when valence is allowed. In some embodiments, z is 6 when valence is allowed.

[0289] In some embodiments, Cy 1 yes , , , , , , , , , , or .

[0290] In some embodiments, Cy 1 yes .

[0291] In some embodiments, Cy 2 It is a C6 arylene or a 5- to 6-membered heteroarylene (e.g., a heteroarylene comprising a 5- or 6-membered ring and 1-4 heteroatoms selected from N, O, and S), wherein the arylene or heteroarylene is optionally surrounded by one or more R u replace.

[0292] In some embodiments, Cy 2 It is optionally controlled by one or more R u The C6 arylene group is replaced. In some embodiments, Cy 2 It is a C6 aryl group.

[0293] In some embodiments, Cy 2 It is optionally controlled by one or more R u Substituted 5- to 6-membered heteroaryl groups (e.g., heteroaryl groups comprising a 5- or 6-membered ring and 1-4 heteroatoms selected from N, O, and S).

[0294] In some embodiments, Cy 2 It is a 5- to 6-membered heteroaryl group (e.g., a heteroaryl group containing a 5- or 6-membered ring and 1-4 heteroatoms selected from N, O and S).

[0295] In some embodiments, Cy 2 It is optionally controlled by one or more R u Substituted 5- to 6-membered heteroaryl groups (e.g., heteroaryl groups comprising a 5- or 6-membered ring and 1-4 heteroatoms selected from N, O, and S).

[0296] In some embodiments, Cy 2 It is a pyridyl group.

[0297] In some embodiments, Cy 2 It is optionally controlled by one or more R u Substituted pyridyl group.

[0298] In some embodiments, Cy 2 It is optionally influenced by one or more halogens, C 1-6 Alkyl or C 1-6 Alkoxy-substituted pyridyl group, wherein the C 1-6 Alkyl groups are optionally surrounded by one or more C groups. 1-6 Alkyl-substituted.

[0299] In some embodiments, Cy 2 yes ,in Indicates Cy 1 connect.

[0300] In some embodiments, Cy 2 yes or ,in Indicates Cy 1 connect.

[0301] In some embodiments, Cy 2 yes , , , , , , , , or ,in Indicates Cy 1 connect.

[0302] In some embodiments, Cy 2 yes or , where ## represents Cy 1 connect.

[0303] In some embodiments, L 2 It is CH2. In some embodiments, L 2 It is CH(C) 1-3 Alkyl group). In some embodiments, L 2 It is CH(CH3).

[0304] In some embodiments, L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace.

[0305] In some embodiments, L 3 It is an E-vinylidene, ethynylene, C6-arylene, or 5- to 6-heteroarylene.

[0306] In some embodiments, L 3 It is optionally controlled by one or more R u Replaced E-vinylidene.

[0307] In some embodiments, L 3 It is unsubstituted E-vinylene.

[0308] In some embodiments, L 3 It is optionally controlled by one or more R u Replaced C6 aryl group.

[0309] In some embodiments, L 3 It is optionally controlled by one or more R u Substituted 1,4-phenylene.

[0310] In some embodiments, L 3 It is an unsubstituted 1,4-phenylene.

[0311] In some embodiments, L 3 It is an ethynyl group.

[0312] In some embodiments, L 3 It is optionally controlled by one or more R u Replaced 5- to 6-membered heteroaryl groups.

[0313] In some embodiments, L 3 It is an unsubstituted 5- to 6-membered heteroaryl group.

[0314] In some embodiments, each R a C is independent 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising one or two 3- to 6-membered rings and 1-4 heteroatoms selected from N, O, and S), wherein the alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0315] In some embodiments, yes , , or .

[0316] In some embodiments, yes or .

[0317] In some embodiments, L is selected from the group consisting of: , , , , , , , , , , , , , , , , , , , , , , , , , , , and .

[0318] In some embodiments, L is .

[0319] In some embodiments, each R b Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising one or two 3- to 6-membered rings and 1-4 heteroatoms selected from N, O, and S), wherein the alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0320] In some embodiments, each R c and each R d Independently, it is hydrogen and C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 3-6A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), cyclobutenyl (C4), cyclopentyl (C5), cyclopentenyl (C5), cyclohexyl (C6), cyclohexenyl (C6), or cyclohexadienyl (C6)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising one or two 3- to 6-membered rings and 1-4 heteroatoms selected from N, O, and S), wherein the alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R u replace.

[0321] In some embodiments, R a R b R c and R d Independently and optionally by one or more R z replace.

[0322] In some embodiments, R z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbon cyclic groups or 3- to 6-membered heterocyclic groups.

[0323] In some embodiments, each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 6-membered heterocyclic group (e.g., a heterocyclic group comprising one or two 3- to 6-membered rings and 1-4 heteroatoms selected from N, O, and S); wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more atoms selected from oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Substitution of carbocyclic groups and 3- to 4-membered heterocyclic groups.

[0324] In some embodiments, each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl groups (e.g., methyl (C1), ethyl (C2), n-propyl (C3), isopropyl (C3), n-butyl (C4), isobutyl (C4), sec-butyl (C4), tert-butyl (C4), pentyl (C5), or hexyl (C6)), C 1-6 Alkoxy groups (e.g., methoxy (C1), ethoxy (C2), propoxy (C3), isopropoxy (C3), n-butoxy (C4), isobutoxy (C4), sec-butoxy (C4), tert-butoxy (C4), pentoxy (C5), or hexoxy (C6)), C 1-6Alkylamino groups (e.g., dimethylamino, diethylamino, di-n-propylamino, di-isopropylamino, di-n-butylamino, di-butylamino, di-sec-butylamino, di-tert-butylamino, dipentylamino, dihexylamino, methylethylamino, methyl-n-propylamino, methyl-isopropylamino, methyl-n-butylamino, methyl-isobutylamino, methyl-sec-butylamino, methyl-tert-butylamino, methylpentylamino, methylhexylamino, ethyl-n-propylamino, ethyl-isopropylamino) Ethyl-n-butylamino, ethyl-sec-butylamino, ethyl-isobutylamino, ethyl-tert-butylamino, ethylpentylamino, ethylhexylamino, propyl-n-butylamino, propyl-isobutylamino, propyl-sec-butylamino, propyl-tert-butylamino, propylpentylamino, propylhexylamino, n-butylpentylamino, isobutylpentylamino, sec-butylpentylamino, tert-butylpentylamino, n-butylhexylamino, isobutylhexylamino, sec-butylhexylamino, tert-butylhexylamino or pentylhexylamino), C 3-4 A carbocyclic group (e.g., cyclopropyl (C3), cyclopropenyl (C3), cyclobutyl (C4), or cyclobutenyl (C4)) or a 3- to 4-membered heterocyclic group (e.g., a heterocyclic group comprising a 3- to 4-membered ring and a heteroatom selected from N, O, and S); wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more elements selected from oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Substitution of carbocyclic groups and 3- to 4-membered heterocyclic groups.

[0325] The following describes embodiments of variables in any of the formulas described herein, such as formulas I, I-1, I-1-i, I-1-i-1, I-1-i-2, I-2, I-3-i, I-3-ii, I-3-iii, I-3-iv, I-3-v, and I-3-vi, if applicable. Any variable can be any part described in the embodiments below. Additionally, combinations of any applicable part describing any variable with any part describing any remaining variable are also considered.

[0326] When listing numerical ranges, each discrete value and subrange within the range is also considered. For example, "C 1-6 "Alkyl" is intended to encompass C1, C2, C3, C4, C5, C6, C 1-6 C 1-5 C 1-4 C 1-3 C 1-2 C 2-6 C 2-5 C 2-4C 2-3 C 3-6 C 3-5 C 3-4 C 4-6 C 4-5 and C 5-6 alkyl.

[0327] In some embodiments, the compounds are selected from the compounds in Tables 1-3 and their pharmaceutically acceptable salts.

[0328] In some embodiments, the compound is selected from the compounds in Tables 1-3.

[0329] In some embodiments, the compounds are selected from the compounds in Table 1 and their pharmaceutically acceptable salts.

[0330] In some embodiments, the compound is selected from the compounds in Table 1.

[0331] In some embodiments, the compounds are selected from the compounds in Table 2 and their pharmaceutically acceptable salts.

[0332] In some embodiments, the compound is selected from the compounds in Table 2.

[0333] In some embodiments, the compounds are selected from the compounds in Table 3 and their pharmaceutically acceptable salts.

[0334] In some embodiments, the compound is selected from the compounds in Table 3.

[0335] In some embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, A79, B1, B5, B30, and B45, as well as pharmaceutically acceptable salts thereof.

[0336] In some embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71, A79, B1, B5, B30, and B45.

[0337] In some embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71 and A79, and their pharmaceutically acceptable salts.

[0338] In some embodiments, the compounds are selected from compound numbers A6, A15, A16, A41, A45, A46, A66, A70, A71 and A79.

[0339] In some embodiments, the compounds are selected from compound numbers B1, B5, B30, and B45, and their pharmaceutically acceptable salts.

[0340] In some embodiments, the compound is selected from compound numbers B1, B5, B30, and B45.

[0341] To date, heterobifunctional protein degraders have presented both opportunities and challenges. The greatest challenge is that, unlike traditional small molecule drugs, they do not meet the classic “Rule of Five” (RO5) proposed by Christopher A. Lipinski in 1997: molecular weight (MW) < 500 kDa; solubility (LogP) < 5; H-bond donors (HBD) < 5; H-bond acceptors (HBA) < 10; and number of rotatable bonds (nRotB) < 10. Compounds that meet Lipinski’s rule have a higher probability of exhibiting favorable pharmacokinetic (PK) properties and high oral bioavailability compared to compounds that do not meet RO5. Although heterobifunctional degraders are considered small molecule compounds, they often violate RO5 due to their molecular weight > 500 kDa and several other RO5 parameters exceeding the cutoff value. Therefore, poor oral absorption is a common and major problem for heterobifunctional degraders.

[0342] To screen degraders with acceptable oral bioavailability, careful characterization and optimization of parameters such as molecular weight, solubility, topological polar surface area (tPSA), H-bond donors, H-bond acceptors, number of rotatable bonds, and metabolic stability / permeability are required. Additionally, optimization for selective off-target proteins is necessary. In fact, many current studies only demonstrate the effectiveness of designed degraders in degrading target proteins and their antiproliferative activity at the cellular level, while acknowledging the challenges of achieving orally bioavailable compounds.

[0343] This disclosure is based, in at least part, on the finding that the compounds disclosed herein can have improved oral bioavailability compared to other p300 degraders.

[0344] Compared to other p300 degrading agents, the compounds disclosed herein may also possess advantageous properties. For example, the compounds disclosed herein may potentially exhibit greater selectivity for p300 than CBP, may demonstrate more effective degradation activity against p300, and may have more favorable pharmacokinetic properties (e.g., as per CBP). max T max (and / or AUC measured), and / or less interaction with other cellular targets (e.g., hepatocyte transporters such as OATP1B1), and thus improved safety (e.g., drug-drug interactions).

[0345] In some embodiments, when the compound is reacted with the DC of p300 50 Lower than its DC for CBP 50 (When both values ​​are measured at the same time point), the compounds disclosed herein exhibit selective degradation of p300 exceeding that of CBP. In some embodiments, when the compounds affect the D-value of p300... max Greater than its D for CBP max The compounds disclosed herein exhibit selectivity when both values ​​are measured at the same time point. In some embodiments, the compounds disclosed herein exhibit selectivity by means of a lower DC value for p300 compared to those for CBP. 50 and larger D max The combination of the two exhibits selectivity. In some embodiments, when the compound is reacted with the DC of p300... 50 Compared to its DC for CBP 50 At least 10 times lower and / or D compared to p300 max Subtract D from CBP max The value of (ΔD) max The compounds disclosed herein exhibit selectivity when the concentration of p300 is at least 30, at least 35, at least 40, or at least 45 percentage points. In some preferred embodiments, when the concentration of p300 is at least 30, at least 35, at least 40, or at least 45 percentage points, the compounds exhibit selectivity. 50 Compared to its DC for CBP 50At least 30 times lower and / or D compared to p300 max Subtract D from CBP max The value of (ΔD) max The compounds disclosed herein exhibit selectivity when the concentration of p300 is at least 50, at least 55, at least 60, or at least 65 percentage points. In some more preferred embodiments, when the concentration of p300 by the compound is at least 50, at least 55, at least 60, or at least 65 percentage points, the compounds exhibit selectivity. 50 Compared to its DC for CBP 50 At least 100 times lower and / or D compared to p300 max Subtract D from CBP max The value of (ΔD) max The compounds disclosed herein exhibit selectivity when the percentages are at least 70, at least 75, at least 80, at least 85, or at least 90 percentage points. In some embodiments, the D-value of the compounds disclosed herein, measured at short time points (e.g., 2 hours), is significant. max Equal to or greater than its D-value for CBP measured at significantly longer time points (e.g., 24 hours). max At that time, the compound exhibits selectivity. In some preferred embodiments, even under stringent measurements (2 hours for p300 and 48 hours for CBP), the compound has at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, or at least 90 percentage points (ΔD). max These beneficial properties of the compounds disclosed herein can be measured according to methods commonly available in the art, such as those exemplified herein.

[0346] Due to the presence of double bonds, the compounds disclosed herein can be in cis or trans configurations, or Z or E configurations. It should be understood that although one configuration may be depicted in the structure of the compounds or formulas disclosed herein, other configurations are also covered. For example, the compounds or formulas disclosed herein may be depicted in cis or trans configurations, or in Z or E configurations.

[0347] In one embodiment, the compound of this disclosure (e.g., a compound of any formula disclosed herein or any single compound) is a pharmaceutically acceptable salt. In one embodiment, the compound of this disclosure (e.g., a compound of any formula disclosed herein or any single compound) is a solvate. In another embodiment, the compound of this disclosure (e.g., a compound of any formula disclosed herein or any single compound) is a hydrate.

[0348] Pharmaceutically acceptable salts In some embodiments, the compounds disclosed herein are present as pharmaceutically acceptable salts. In some embodiments, the methods disclosed herein include methods of treating a disease by administering such pharmaceutically acceptable salts. In some embodiments, the methods disclosed herein include methods of treating a disease by administering such pharmaceutically acceptable salts as a pharmaceutical composition.

[0349] In some embodiments, the compounds described herein have acidic or basic groups, and thus react with a number of inorganic or organic bases, as well as any of inorganic and organic acids, to form pharmaceutically acceptable salts. In some embodiments, these salts are prepared in situ during the final isolation and purification of the compounds disclosed herein, or by reacting the purified compound, in its free form, alone with a suitable acid or base and isolating the resulting salt.

[0350] Examples of pharmaceutically acceptable salts include those prepared by reacting the compounds described herein with mineral acids, organic acids, or inorganic bases. These salts include acetates, acrylates, adipates, alginates, aspartates, benzoates, benzenesulfonates, hydrogen sulfates, bisulfites, bromides, butyrates, butyn-1,4-dicitates, camphor salts, camphorsulfonates, hexanoates, octanoates, chlorobenzoates, chlorides, citrates, cyclopentanepropionates, decanoates, disaccharides, dihydrogen phosphates, dinitrobenzoates, dodecyl sulfates, ethanesulfonates, formates, fumarates, glucono-heptyl sulfates, glycerophosphates, glycolates, hemisulfates, heptanates, hexyn-1,6-dicitates, hydroxybenzoates, and γ-hydroxybutyrates. Salts, hydrochlorides, hydrobromides, hydroiodates, 2-hydroxyethanesulfonates, iodides, isobutyrates, lactates, maleates, malonates, methanesulfonates, mandelates, metaphosphates, methanesulfonates, methoxybenzoates, methylbenzoates, monohydrogen phosphates, 1-naphthalenesulfonates, 2-naphthalenesulfonates, nicotinates, nitrates, palmitates, pectinates, persulfates, 3-phenylpropionates, phosphates, picrates, neopentanoates, propionates, pyrosulfates, pyrophosphates, propionates, phthalates, phenylacetates, phenylbutyrates, propionylsulfonates, salicylates, succinates, sulfates, sulfites, succinates, octanoates, sebacic acid salts, sulfonates, tartrates, thiocyanates, undecenoate toluenesulfonate, and xylenesulfonates.

[0351] Furthermore, the compounds described herein can be prepared into pharmaceutically acceptable salts by reacting the free base form of the compounds with pharmaceutically acceptable inorganic or organic acids, including but not limited to inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, metaphosphoric acid, etc.; and organic acids such as acetic acid, propionic acid, hexanoic acid, cyclopentanepropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, p-toluenesulfonic acid, tartaric acid, trifluoroacetic acid, citric acid, benzoic acid, 3... -(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, arylsulfonic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethanedisulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, 2-naphthalenesulfonic acid, 4-methylbicyclo-[2.2.2]oct-2-en-1-carboxylic acid, gluconepic acid, 4,4'-methylenebis-(3-hydroxy-2-en-1-carboxylic acid), 3-phenylpropionic acid, trimethylacetic acid, tert-butylacetic acid, dodecyl sulfate, gluconic acid, glutamic acid, hydroxynaphthoic acid, salicylic acid, stearic acid, and mucoconic acid.

[0352] In some embodiments, those compounds comprising free acid groups described herein react with suitable bases, such as hydroxides, carbonates, bicarbonates, or sulfates of pharmaceutically acceptable metal cations, with ammonia, or with pharmaceutically acceptable primary, secondary, tertiary, or quaternary organic amines. Representative salts include alkali metal or alkaline earth metal salts, such as lithium, sodium, potassium, calcium, and magnesium salts, as well as aluminum salts. Illustrative examples of bases include sodium hydroxide, potassium hydroxide, choline hydroxide, sodium carbonate, N2O2, etc. + (C 1-4 Alkyl)4, etc.

[0353] Representative organic amines that can be used to form base addition salts include ethylamine, diethylamine, ethylenediamine, ethanolamine, diethanolamine, piperazine, etc. It should be understood that the compounds described herein also include quaternization of any basic nitrogen-containing groups they contain. In some embodiments, such quaternization yields water- or oil-soluble or dispersible products.

[0354] solvates "Solvate" refers to a compound form that typically associates with a solvent or water via a solvent decomposition reaction (also known as a "hydrate"). This physical association involves hydrogen bonding. Common solvents include water, ethanol, acetic acid, etc. The compounds disclosed herein can be prepared, for example, in crystalline form and can be solvated or hydrated. Suitable solvates include pharmaceutically acceptable solvates, such as hydrates, and also include both stoichiometric and non-stoichiometric solvates. In some cases, solvates will be separable (e.g., when one or more solvent molecules are incorporated into the crystal lattice of a crystalline solid). "Solvate" encompasses both solution phases and separable solvates. Representative solvates include hydrates, ethanolates, and methanolates.

[0355] Those skilled in the art of organic chemistry will recognize that many organic compounds can form complexes with solvents, in which they react or precipitate or crystallize. These complexes are called "solvents." For example, a complex with water is called a "hydrate." Solvents are within the scope of this disclosure.

[0356] Those skilled in the art of organic chemistry will also recognize that many organic compounds can exist in more than one crystalline form. For example, the crystalline form can vary depending on the solvate. Therefore, all crystalline forms or pharmaceutically acceptable solvates are taken into consideration and are within the scope of this disclosure.

[0357] In some embodiments, the compounds described herein are present as solvates. This disclosure provides methods for treating diseases by applying such solvates. This disclosure also provides methods for treating diseases by applying such solvates as pharmaceutical compositions.

[0358] The solvates contain stoichiometric or non-stoichiometric amounts of solvent, such as water, ethanol, etc. When the solvent is water, a hydrate is formed, or when the solvent is an alcohol, an alcohol is formed. The solvates of the compounds described herein can be conveniently prepared or formed during the methods described herein. Furthermore, the compounds provided herein can exist in both solvated and non-solvated forms. Generally, for the purposes of the compounds and methods provided herein, the solvated and non-solvated forms are considered equivalent.

[0359] Isomers (stereoisomers, geometric isomers, tautomers, etc.) It should also be understood that compounds with the same molecular formula but different atomic bonding properties or sequences or different spatial arrangements of atoms are called "isomers". Isomers with different spatial arrangements of atoms are called "stereoisomers".

[0360] Stereoisomers that are not mirror images of each other are called "diastereomers," and those that are non-overlapping mirror images of each other are called "enantiomers." When a compound has an asymmetric center, for example, said asymmetric center bonded to four different groups, there may be a pair of enantiomers. Enantiomers can be characterized by the absolute configuration of their asymmetric center and are described and designated as dextrorotatory or levorotatory (i.e., designated as (+) or (-) isomers, respectively) by the Cahn and Prelog R and S sequencing rules or by rotating the molecular polarization plane. Chiral compounds can exist as individual enantiomers or mixtures thereof. A mixture containing equal proportions of enantiomers is called a "racemic mixture."

[0361] As used herein, a pure enantiomer is substantially free of other enantiomers or stereoisomers of the compound (i.e., enantiomer excess). In other words, the “S” form of the compound is substantially free of the “R” form of the compound, and therefore is in excess of the “R” form enantiomer. The terms “enantiomer-pure” or “pure enantiomer” mean that the compound contains greater than 95% by weight, greater than 96% by weight, greater than 97% by weight, greater than 98% by weight, greater than 98.5% by weight, greater than 99% by weight, greater than 99.2% by weight, greater than 99.5% by weight, greater than 99.6% by weight, greater than 99.7% by weight, greater than 99.8% by weight, or greater than 99.9% by weight of enantiomers. In some embodiments, the weight is based on the total weight of all enantiomers or stereoisomers of the compound.

[0362] As used herein and unless otherwise stated, the term "enantiomerically pure (R)-compound" means at least about 95% by weight of the (R)-compound and at most about 5% by weight of the (S)-compound, at least about 99% by weight of the (R)-compound and at most about 1% by weight of the (S)-compound, or at least about 99.9% by weight of the (R)-compound and at most about 0.1% by weight of the (S)-compound. In some embodiments, the weight is based on the total weight of the compounds.

[0363] As used herein and unless otherwise stated, the term "enantiomerically pure (S)-compound" means at least about 95% by weight of the (S)-compound and at most about 5% by weight of the (R)-compound, at least about 99% by weight of the (S)-compound and at most about 1% by weight of the (R)-compound, or at least about 99.9% by weight of the (S)-compound and at most about 0.1% by weight of the (R)-compound. In some embodiments, the weight is based on the total weight of the compound.

[0364] In the compositions provided herein, enantiomerically pure compounds or their pharmaceutically acceptable salts, solvates, hydrates, or prodrugs may be present with other active or inactive ingredients. For example, a pharmaceutical composition comprising an enantiomerically pure (R)-compound may comprise, for example, about 90% excipients and about 10% enantiomerically pure (R)-compounds. In some embodiments, such compositions may, by total weight of the compounds, comprise, for example, at least about 95% by weight of (R)-compounds and at most about 5% by weight of (S)-compounds. For example, a pharmaceutical composition comprising an enantiomerically pure (S)-compound may comprise, for example, about 90% excipients and about 10% enantiomerically pure (S)-compounds. In some embodiments, such compositions may, by total weight of the compounds, comprise, for example, at least about 95% by weight of (S)-compounds and at most about 5% by weight of (R)-compounds. In some embodiments, the active ingredient may be formulated with minimal excipients or carriers.

[0365] Unless otherwise stated, the description or naming of a particular compound in the specification and claims is intended to include individual enantiomers and racemic mixtures or other mixtures thereof. Methods for determining stereochemistry and separating stereoisomers are well known in the art.

[0366] In some embodiments, the compounds described herein exist as geometric isomers. In some embodiments, the compounds described herein have one or more double bonds. The compounds disclosed herein include all cis, trans, cis-trans, isolateral (E), and isolateral (Z) isomers and corresponding mixtures thereof. All geometric forms of the compounds disclosed herein are taken into account and are within the scope of this disclosure.

[0367] In some embodiments, the compounds disclosed herein have one or more chiral centers, each present in an R or S configuration. The compounds disclosed herein include all diastereomers, enantiomers, and epimers, and corresponding mixtures thereof. All diastereomers, enantiomers, and epimers of the compounds disclosed herein are considered and are within the scope of this disclosure.

[0368] In further embodiments of the compounds and methods provided herein, mixtures of enantiomers and / or diastereomers produced by a single preparation step, combination, or tautomerization can be used for the applications described herein. In some embodiments, the compounds described herein are prepared as individual stereoisomers by reacting a racemic mixture of compounds with an optically active resolving agent to form a pair of diastereomeric compounds, separating the diastereomers, and recovering the optically pure enantiomers. In some embodiments, dissociable complexes are preferred. In some embodiments, the diastereomers have different physical properties (e.g., melting point, boiling point, solubility, reactivity, etc.) and are separated by utilizing these differences. In some embodiments, the diastereomers are separated by chiral chromatography, or preferably by a separation / resolution technique based on solubility differences. In some embodiments, the optically pure enantiomers and the resolving agent are then recovered.

[0369] tautomer In some embodiments, the compounds described herein exist as tautomers. The compounds described herein include all possible tautomers of the formulas described herein.

[0370] Tautomers are compounds that can interconvert through the migration of hydrogen atoms, accompanied by the conversion of single bonds and adjacent double bonds. In the bond arrangements where tautomerism is possible, there will be a chemical equilibrium of tautomers. For example, enols and ketones are tautomers because they rapidly interconvert upon treatment with an acid or base. Another example of tautomerism is the acid- and nitro-forms of phenylnitromethane, which are also formed by treatment with an acid or base. The tautomer form can be associated with obtaining optimal chemical reactivity and biological activity of the target compound. All tautomer forms of the compounds disclosed herein are considered and are within the scope of this disclosure. The exact ratio of tautomers depends on several factors, including temperature, solvent, and pH.

[0371] Pharmaceutical Composition In some embodiments, the compounds described herein are administered as pure chemicals. In some embodiments, the compounds described herein are combined with one or more pharmaceutically suitable or acceptable carriers (also referred to herein as one or more pharmaceutically suitable (or acceptable) excipients, physiologically suitable (or acceptable) excipients, or physiologically suitable (or acceptable) carriers), the carriers being selected according to the chosen route of administration and standard pharmaceutical practice as described in, for example, Remington: Pharmaceutical Science and Practice (…). Remington: The Science and Practice of Pharmacy(Gennaro, 21st edition, Mack Pub. Co., Easton, PA (2005)).

[0372] Therefore, this disclosure provides pharmaceutical compositions comprising the compound described herein or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, and a pharmaceutically acceptable excipient.

[0373] In some embodiments, the compounds provided herein are substantially pure because they contain less than about 5%, less than about 1%, or less than about 0.1% of other small organic molecules, such as unreacted intermediates or synthetic byproducts generated in one or more steps of, for example, a synthetic method.

[0374] The pharmaceutical composition is administered in a manner suitable for the treatment (or prevention) of a disease. The appropriate dosage and suitable duration and frequency of administration will be determined by factors such as the patient's condition, the type and severity of the patient's disease, the specific form of the active ingredient, and the method of administration. Generally, an appropriate dosage and treatment regimen provides a quantity of the composition sufficient to provide therapeutic and / or preventive benefits (e.g., improved clinical outcomes, such as more frequent complete or partial remissions, or longer disease-free survival and / or overall survival, or reduction in symptom severity). Optimal dosage is typically determined using experimental models and / or clinical trials. The optimal dosage depends on the patient's body mass, weight, or blood volume.

[0375] In some embodiments, the pharmaceutical composition is formulated for oral, topical (including buccal and sublingual), rectal, vaginal, percutaneous, parenteral, intrapulmonary, intradermal, intrathecal, epidural, and intranasal administration. Parenteral administration includes intramuscular, intravenous, intraarterial, intraperitoneal, or subcutaneous administration. In some embodiments, the pharmaceutical composition is formulated for intravenous injection, oral administration, inhalation, nasal administration, topical administration, or ocular administration. In some embodiments, the pharmaceutical composition is formulated for oral administration. In some embodiments, the pharmaceutical composition is formulated for intravenous injection. In some embodiments, the pharmaceutical composition is formulated as tablets, pills, capsules, liquids, inhalers, nasal spray solutions, suppositories, suspensions, gels, colloids, dispersants, suspensions, solutions, emulsions, ointments, lotions, eye drops, or ear drops. In some embodiments, the pharmaceutical composition is formulated as tablets.

[0376] Preparation and characterization of compounds The compounds disclosed herein can be prepared using many methods well known to those skilled in the art of organic synthesis. For example, the compounds disclosed herein can be synthesized using the methods described below, as well as synthetic methods known in the field of synthetic organic chemistry, or variations thereof recognized by those skilled in the art. The compounds disclosed herein (i.e., the compounds of this application (e.g., any compound of any formula disclosed herein or any single compound)) can be synthesized by following the general synthetic schemes below and the steps outlined in the examples, schemes, procedures and / or syntheses (e.g., examples) described herein.

[0377] General synthesis scheme Compound I-1' can be prepared according to the procedure shown in Scheme 1A.

[0378] Option 1A According to Scheme 1A, at a temperature ranging from 60°C to 100°C, preferably 60°C; using a suitable organic base such as TEA, DIPEA, DBU; reacting a commercially available or synthetically accessible substituted aromatic hydrocarbon of formula I-1'-1a with a commercially available or synthetically accessible substituted bromide of formula I-1'-2a; to provide a compound of formula I-1'.

[0379] R D1 Compounds of formula I-1' with = H can be prepared alternatively according to the procedure shown in scheme 1B.

[0380] \ Option 1B According to Scheme 1B, based on standard Buchwald-Hartwig conditions, standard Suzuki-Miyuara conditions, standard Negishi conditions, and standard Stille conditions, suitable palladium catalysts such as Pd(dppf)Cl2, Pd(PPh3)4, and PdX-Phos G2 are used; and catalysts such as Na2CO3, Cs2CO3, K3PO4, and K2O are used or not. tA commercially available or synthetically accessible substituted aromatic hydrocarbon I-1'-1b (Y = Cl, Br, I, OTf, etc.) is coupled with a commercially available or synthetically accessible substituted pyridine I-1'-2b (U = H, B(OR)2, ZnCl, SnR3, etc.) in a suitable solvent such as Bu or anhydrous dioxane, THF, DMF, toluene, at a temperature ranging from 40°C to 120°C to provide a compound of formula I-1'-3b coupled together. Then, in a suitable solvent such as EtOH or MeOH, with a suitable hydride source such as a H2 atmosphere, and at a temperature ranging from 40°C to 120°C, the bis(benzyloxy)pyridine of formula I-1'-3b is reduced using a suitable inorganic catalyst such as Pd / C or Pd(OH)2 to provide a compound of formula I-1'.

[0381] Compound of formula I-3-i can be prepared according to the procedure shown in Scheme 2.

[0382] Option 2 According to Scheme 2, in a suitable solvent such as THF or dioxane, and at a temperature ranging from -60°C to 25°C, a commercially available or synthetically accessible substituted nitro compound of formula I-3-i-1 is reacted with a vinyl Grignard agent of formula I-3-i-2 (X = Br, Cl, or I) to provide a cyclized compound of formula I-3-i-3. In a suitable solvent such as DCM or dichloroethane, and at a temperature ranging from 0°C to 60°C, preferably 25°C, the cyclized compound of formula I-3-i-3 is acylated with a suitable Lewis acid such as AlCl3 or BF3 ethers, using commercially available 2,2,2-trichloroacetyl chloride to provide an acylated compound of formula I-3-i-4. In a suitable mixed solvent such as THF or MeOH mixed with water, at a temperature ranging from 25°C to 80°C, the acylated compound of formula I-3-i-4 is hydrolyzed with a suitable inorganic base such as KOH or NaOH to provide an acid of formula I-3-i-5. Then, using a catalyst such as DMF, in a suitable solvent such as DCM or dichloroethane, at a temperature ranging from 0°C to 80°C, the acid of formula I-3-i-5 is acylated with a suitable chlorine source such as SOCl2 or oxalyl chloride to provide an acyl chloride compound of formula I-3-i-6. In a suitable solvent such as DCM or THF, at a temperature ranging from -10°C to 20°C, the acyl chloride compound of formula I-3-i-6 is coupled with a commercially available or synthetically accessible amine source using a suitable organic base such as TEA or DIPEA to provide an amide of formula I-3-i (R). F4 = amide).

[0383] Compound of formula I-3-ii can be prepared according to the procedure shown in Scheme 3.

[0384] Option 3 According to Scheme 3, a commercially available or synthetically accessible biphenylamine of Formula I-3-ii-1 is reacted with a carbon monoxide inserter such as CDI or triphosgene in an organic base such as TEA or DIPEA, in a suitable solvent such as DCM or DMF, at a temperature ranging from 0°C to 60°C to provide a urea compound of Formula I-3-ii-2. The urea compound of Formula I-3-ii-2 is alkylated with a commercially available or synthetically accessible substituted alkyl halide in a suitable solvent such as DMF or THF, at a temperature ranging from 0°C to 60°C, preferably 40°C, in an inorganic base such as NaH or t-BuOK to provide a substituted urea compound of Formula I3-ii-3. In an inorganic base such as Na2CO3 or K3PO4; in a suitable solvent such as THF or dioxane; at a temperature ranging from 0°C to 100°C, preferably 40°C; with a suitable catalyst such as Pd(Ph3P)4 or PdCl2(Ph3P)2; a urea compound of formula I-3-ii-3 (X = halide) is reacted with a commercially available or synthetically accessible substituted alkyl or borate vinyl ester (Suzuki), zinc (Negishi), or magnesium (Kumada) reagent I-3-ii-4 to provide a compound of formula I3-ii substituted.

[0385] Compound I-3-iii can be prepared according to the procedure shown in Scheme 4.

[0386] Option 4 According to Scheme 4, in a suitable solvent such as DMF or DMSO, at a temperature ranging from 50°C to 120°C, a commercially available or synthetically accessible substituted aryl nitro compound of formula I-3-iii-1 is reacted with a commercially available or synthetically accessible substituted amino acid of formula I-3-iii-2 using a suitable inorganic base such as K₂CO₃ or Cs₂CO₃ to provide a coupled compound of formula I-3-iii-3. In an acidic solvent such as HOAc or 1 N HCl aqueous solution, at a temperature ranging from 80°C to 120°C, preferably 100°C, the nitro compound of formula I-3-iii-3 is reduced using a suitable reducing agent such as Fe or SnCl₂ to provide a cyclized compound of formula I-3-iii.

[0387] Compound I-3-iv can be prepared according to the procedure shown in Scheme 5.

[0388] Option 5 According to Scheme 5, in a suitable solvent such as acetone, DMF, or DMSO, at a temperature ranging from 50°C to 120°C, using a suitable inorganic base such as K₂CO₃ or Cs₂CO₃, a commercially available or synthetically accessible substituted ketone ester compound of formula I-3-iv-1 is alkylated with a commercially available or synthetically accessible substituted bromide ester of formula I-3-iv-2 to provide a coupled compound of formula I-3-iv-3. In an acidic solvent such as HOAc or 1 N HCl aqueous solution, at a temperature ranging from 40°C to 100°C, preferably 60°C, the ketone ester compound of formula I-3-iv-3 is decarboxylated with a suitable acid such as HCl or H₂SO₄ to provide a keto acid compound of formula I-3-iv-4. In a suitable solvent such as DMF or DMSO, at a temperature ranging from 0°C to 80°C, and using a suitable coupling agent such as T3P or HATU, a keto acid compound of formula I-3-iv-4 is coupled to a commercially available or synthetically accessible substituted amino ester compound of formula I-3-iv-5 to provide a coupled compound of formula I-3-iv-6. In a suitable solvent such as THF or dioxane, at a temperature ranging from -78°C to 0°C, and using a suitable base such as LDA or LiHMDS, the coupled compound of formula I-3-iv-6 is cyclized under indole condensation conditions to provide a cyclized keto-enol compound of formula I-3-iv-7. In a suitable solvent such as MeOH or EtOH, at a temperature ranging from 25°C to 80°C, the keto-enol compound of formula I-3-iv-7 is reacted with a commercially available or synthetically accessible substituted hydrazine compound of formula I-3-iv-8 to provide a compound of formula I-3-iv coupled.

[0389] Compound I-3-v can be prepared according to the procedure shown in Scheme 6.

[0390] Option 6 According to Scheme 6, in a suitable solvent such as DMF or DMSO, at a temperature ranging from 0°C to 80°C, using a suitable coupling agent such as HATU or T3P, and a suitable organic base such as TEA or DIPEA, a commercially available or synthetically accessible substituted amine compound of formula I-3-v-1 is coupled with a commercially available or synthetically accessible substituted acid of formula I-3-v-2 to provide a coupled amide compound of formula I-3-v-3. In an aprotic polar solvent such as DMF, at a temperature ranging from 60°C to 100°C, preferably 80°C, the amide compound of formula I-3-v-3 is cyclized using a suitable reactive chlorine source such as POCl3 or SOCl2 to provide a cyclized pyrazine compound of formula I-3-v-4. The cyclopyrazine compound of formula I-3-v-4 is reduced in a suitable solvent such as EtOAc or MeOH, at a temperature ranging from 25°C to 80°C, using a suitable catalyst such as 10% Pd / C or Pd(OH)2 / C, and a suitable reducing agent such as H2 gas at up to 50 psi or ammonium formate, to provide the reduced compound of formula I-3-v-5. The reduced compound of formula I-3-v-5 is acylated in a suitable organic base such as TEA or DIPEA, in a suitable solvent such as DCM or dichloroethane, at a temperature ranging from -10°C to 25°C, using a commercially available or synthetically accessible acylation agent of formula I-3-v-6, to provide the acylated compound of formula I-3-v.

[0391] Compounds of formula I-3-vi-a or I-3-vi-b can be prepared according to the procedure shown in Scheme 7.

[0392] Option 7 According to Scheme 7, in a suitable solvent such as DCM or dichloroethane, at a temperature ranging from -10°C to 50°C, using a suitable organic base such as TEA or DIPEA, a commercially available or synthetically accessible substituted aniline of formula I-3-vi-a-1 or I-3-vi-b-1 is reacted with a commercially available or synthetically accessible substituted acyl halide (X = Cl or Br) of formula I-3-vi-a-3 or I-3-vi-b-3 to provide a compound coupled to formula I-3-vi-a-3 or I-3-vi-b-3. In an aprotic polar solvent such as DMF, at a temperature ranging from 0°C to 80°C, the acylated compound of formula I-3-vi-a-3 or I-3-vi-b-3 is reduced using a suitable chlorine source reagent such as POCl3 or SOCl2 to provide a cyclized compound of formula I-3-vi-a-4 or I-3-vi-b-4. In a mixed solvent such as MeOH; or in an aqueous solution; at a temperature ranging from 0°C to 60°C; or with a suitable base such as NaOH or KOH, the aryl chloride compound of formula I-3-vi-a-4 or I-3-vi-b-4 is hydrolyzed to provide a cyclized compound of formula I-3-vi-a or I-3-vi-b.

[0393] Compound I-2 can be prepared according to the procedure shown in Scheme 8.

[0394] Option 8 According to Scheme 8, a commercially available or synthetically accessible substituted aryl halide (X = Cl, Br, or OTf) of Formula I-2'-1 is reacted with a commercially available or synthetically accessible aryl metal reagent (Y = B, Zn, or Mg) of Formula I-2'-2 in a suitable solvent such as Pd(Ph3P)4 or PdCl2dppf, with or without an inorganic base such as Na2CO3 or K3PO4, at a temperature ranging from 60°C to 100°C, to provide a coupled compound of Formula I-2'-3. The ester of Formula I-2'-3 is reacted with a suitable reagent such as LiOH in a suitable solvent such as THF mixed with water, at a temperature ranging from 0°C to 60°C, preferably room temperature, to provide a carboxylic acid of Formula I-2'-4. In organic solvents such as DCM and DMF; at temperatures ranging from 0°C to 60°C; using coupling agents such as HATU and T3P; the acid of formula I-2'-4 is reacted with a commercially available or synthetically accessible substituted amine of formula I-2'-5; to provide an amide compound of formula I-2'-coupled.

[0395] Compound I can be prepared according to the procedure shown in Scheme 9.

[0396] Option 9 According to Scheme 9, a suitable catalyst such as Pd(Ph3P)4 or PdCl2dppf can be used (Suzuki); or a suitable catalyst such as Pd2(dba)3 or Pd(OAc)2 can be used (Buchwald), with or without catalysts such as Na2CO3 or K3PO4. t -Inorganic bases such as BuONa; in suitable solvents such as dioxane and DMF; at temperatures ranging from 60°C to 120°C; reacting a synthetically accessible substituted aryl halide (Cl, Br, or OTf) with a synthetically accessible L (connector) (boron ester, Zn, or Mg halide) using formula T as the target ligand; to provide a compound coupled to formula TL. Suzuki coupling is carried out via catalysis by Pd(Ph3P)4, PdCl2dppf, etc.; or by catalysis by PdCl2(Ph3P)2 and CuI, etc.; in organic solvents such as dioxane and DMF; with or without organic bases such as TEA and DIPEA; at temperatures ranging from 0°C to 100°C; reacting a compound coupled to formula TL (target ligand and connector) with a commercially available or synthetically accessible E3 ligand of formula C; to provide a degradative compound coupled to formula TLC(I). Those skilled in the art will recognize that, depending on the particular compound, these steps can be reversed. They will also recognize that, where the reactivity of the particular compound permits, these steps can be interspersed with the steps described in schemes 1-8 above.

[0397] Those skilled in the art will recognize the presence of a stereocenter in the compounds disclosed herein (e.g., compounds of any formula disclosed herein or any single compound). Therefore, this disclosure includes two possible stereoisomers (unless otherwise stated in the synthesis) and includes not only racemic compounds but also single enantiomers and / or diastereomers. When a single enantiomer or diastereomer is required, it can be obtained by stereooriented synthesis or by resolving the final product or any convenient intermediate. The resolving of the final product, intermediate, or starting material can be influenced by any suitable method known in the art. See, for example, “Stereochemistry of Organic Compounds”, EL Eliel, SH Wilen, and LN Mander (Wiley-Interscience, 1994).

[0398] The compounds used in the reactions described herein are prepared from commercially available chemicals and / or compounds described in chemical literature, according to organic synthesis techniques known to those skilled in the art. "Commercially available chemicals" are obtained from standard commercial sources, including Acros Organics (Pittsburgh, PA), Aldrich Chemical (Milwaukee, WI, including Sigma Chemical and Fluka) (Pittsburgh, PA).

[0399] Suitable reference books and papers that detail the synthesis of reactants used to prepare the compounds described herein or that provide reference to articles describing the preparations include, for example, *Synthetic Organic Chemistry*, John Wiley & Sons, Inc., New York; *Organic Functional Group Preparations*, 2nd ed., Academic Press, New York, 1983; *Advanced Organic Chemistry: Reactions, Mechanisms and Structure*, 4th ed., Wiley-Interscience, New York, 1992; and *Chemistry of Functional Groups*, John Wiley & Sons, Inc., Volume 73.

[0400] Specific and similar reactants are optionally identified by an index of known chemicals prepared by the American Chemical Society's Chemical Abstracts Service, which is available in most public and university libraries as well as online. Known but not commercially available chemicals are optionally prepared by custom chemical synthesis facilities, many of which provide custom synthesis services (e.g., those listed above). References for the preparation and selection of pharmaceutical salts of the compounds described herein are: PH Stahl and CG Wermuth, “Handbook of Pharmaceutical Salts”, Verlag Helvetica ChimicaActa, Zurich, 2002.

[0401] Analytical methods, materials and instruments Unless otherwise specified, reagents and solvents obtained from commercial suppliers were used. Proton nuclear magnetic resonance (NMR) spectra were obtained at 400 MHz on a Bruker or Varian spectrometer. Spectra are given in ppm (δ) and coupling constant J is reported in Hertz. Tetramethylsilane (TMS) was used as an internal standard. Liquid chromatography-mass spectrometry (LC / MS) was collected using a SHIMADZU LCMS-2020EV or an Agilent 1260-6125B LCMS. Purity and low-resolution mass spectrometry data were measured using an Agilent 1260-6125B LCMS system (with diode array detector and Agilent G6125BA mass spectrometer) or a Waters Acquity UPLC system (with diode array detector and Waters 3100 mass detector). Purity was characterized by UV wavelengths of 214 nm, 220 nm, 254 nm, and ESI. Column: Poroshell 120 EC-C18 2.7 μm 4.6 X 100 mm; flow rate 0.8 mL / min; solvent A (100 / 0.1 water / formic acid), solvent B (100 acetonitrile); gradient: hold 5% B for 0.3 min, 5%-95% B from 0.3 min to 2 min, hold 95% B for 4.8 min, 95%-5% B from 4.8 min to 5.4 min, then hold 5% B for 6.5 min. Alternatively, column: Acquity UPLC BEH C18 1.7 µm 2.1 X 50 mm; flow rate 0.5 mL / min; solvent A (0.1% formic acid in water), solvent B (acetonitrile); gradient: hold 5% B for 0.2 min, 5%-95% B from 0.2 min to 2.0 min, hold 95% B for 3.1 min, then hold 5% B for 3.5 min.

[0402] Bioassay The biological activity of the compounds disclosed herein can be evaluated using methods and assays known in the art.

[0403] The binding potency of the compound to p300 can be determined using HTRF assays. This can be achieved by replacing the fluorescent probe 5-(8-(7-acetyl-3-(tetrahydro-2-ethylhexyl)) from the FLAG-labeled p300 with the tested compound. H -pyran-4-yl)-5,6,7,8-tetrahydroimidazo[1,5- a ]pyrazin-1-yl)isoquinoline-3-yl)- N -(2-(2-(2-(3-(3',6'-dihydroxy-3-oxo-3) H The HTRF signal can be measured using spiro[isobenzofuran-1,9'-xanthan]-5-yl)thiourea)ethoxy)ethoxy)ethyl)pyridinecarboxamide. Data analysis using four-parameter dose-response curves can be performed using appropriate software (e.g., TIBCO Spotfire) to determine the IC50 of the tested compound. 50 .

[0404] The binding potency of a compound to CBP can be determined using HTRF assays. The 5-(8-(7-acetyl-3-(tetrahydro-2-ethylhexyl)) fluorescent probe from the FLAG-labeled (C-terminal) and His-labeled (N-terminal) CBP constructs can be replaced with the tested compound. H -pyran-4-yl)-5,6,7,8-tetrahydroimidazo[1,5- a ]pyrazin-1-yl)isoquinoline-3-yl)- N -(2-(2-(2-(3-(3',6'-dihydroxy-3-oxo-3) H The HTRF signal can be measured using spiro[isobenzofuran-1,9'-xanthan]-5-yl)thiourea)ethoxy)ethoxy)ethyl)pyridinecarboxamide. Data analysis using four-parameter dose-response curves can be performed using appropriate software (e.g., TIBCOSpotfire) to determine the IC50 of the tested compound. 50 .

[0405] The cellular degradation activity of compounds against p300 can be measured in certain cell types (e.g., A549 P300 HiBit cells) using HiBit technology, where the tested compound is treated at certain initial concentrations (e.g., 0.000064 µM, 0.00019 µM, 0.00057 µM, 0.0017 µM, 0.0051 µM, 0.015 µM, 0.046 µM, 0.14 µM, 0.42 µM, and 1.25 µM) for a specific time period (e.g., 2 hours). The resulting protein concentration can be assessed using an assay buffer (e.g., HiBit lysis assay buffer). The resulting luminescence can be measured using appropriate instruments (e.g., PerkinElmer EnVision plate reader). Dose-response curves can be generated and analyzed using appropriate software (e.g., TIBCO Spotfire) to determine the DC of the tested compound. 50 and D max .

[0406] The cellular degradation activity of compounds against CBP can be measured in certain cells (e.g., A549 CBP HiBit cells) using HiBit technology, where the tested compound is treated at certain initial concentrations (e.g., 0.000064 µM, 0.00019 µM, 0.00057 µM, 0.0017 µM, 0.0051 µM, 0.015 µM, 0.046 µM, 0.14 µM, 0.42 µM, and 1.25 µM) for a certain period of time (e.g., 24 hours). The resulting protein concentration can be assessed using an assay buffer (e.g., HiBit lysis assay buffer). The resulting luminescence can be measured using appropriate instruments (e.g., PerkinElmer EnVision plate reader). Dose-response curves can be generated and analyzed using appropriate software (e.g., TIBCO Spotfire) to determine the DC of the tested compound. 50 and D max .

[0407] The cellular degradation activity of a compound against p300 can be measured in certain cells (e.g., H1299 cells) using intracellular Western blotting, where the tested compound is treated at certain initial concentrations (e.g., 0.0005 µM, 0.0015 µM, 0.0046 µM, 0.014 µM, 0.041 µM, 0.12 µM, 0.37 µM, 1.1 µM, 3.3 µM, and 10 μM) for a certain period of time (e.g., 16 hours). The resulting protein concentration can be assessed using an anti-p300 primary antibody (e.g., anti-human p300 clone D8Z4E) and an IRDye 800CW secondary antibody (e.g., IRDye 800CW goat anti-rabbit IgG). The resulting fluorescence can be measured using an appropriate instrument (e.g., a LI-COR Odyssey CLx instrument). Dose-response curves can be generated and analyzed using appropriate software (e.g., TIBCO Spotfire) to determine the DC of the tested compound. 50 and D max .

[0408] The cellular degradation activity of a compound against CBP can be measured in certain cells (e.g., H1299 cells) using techniques such as intracellular Western blotting, where the tested compound is treated at certain initial concentrations (e.g., 0.0005 µM, 0.0015 µM, 0.0046 µM, 0.014 µM, 0.041 µM, 0.12 µM, 0.37 µM, 1.1 µM, 3.3 µM, and 10 μM) for a certain period of time (e.g., 16 hours). The resulting protein concentration can be assessed using an anti-CBP primary antibody (e.g., anti-human CBP clone D6C5) and an IRDye 800CW secondary antibody (e.g., IRDye 800CW goat anti-rabbit IgG). The resulting fluorescence can be measured using a suitable instrument (e.g., a LI-COR Odyssey CLx instrument). Dose-response curves can be generated and analyzed using suitable software (e.g., TIBCO Spotfire) to determine the DC of the tested compound. 50 and D max .

[0409] The ability of compounds to inhibit cell proliferation can be evaluated using Cell Titer-Glo technology in, for example, wild-type, knockout, and knockout cell lines (e.g., H1299 wild-type, H1299 p300 knockout, and H1299 CBP knockout cell lines). The tested compounds can be evaluated at certain initial concentrations (e.g., 0.0005 µM, 0.0015 µM, 0.0046 µM, 0.014 µM, 0.041 µM, 0.12 µM, 0.37 µM, 1.1 µM, 3.3 µM, and 10 µM) over a specific time period (e.g., 6 days). Cell growth can be assessed using appropriate reagents and instruments (e.g., Cell Titer-Glo luminescent cell viability reagents and PerkinElmer Envision instruments). Dose-response curves can be generated and analyzed using appropriate software (e.g., TIBCO Spotfire) to determine gIC. 50 And the growth-death index (i.e., the percentage of remaining cell growth or cell death observed relative to untreated cells).

[0410] How to use In some aspects, this disclosure provides a method for degrading proteins in a subject or biological sample, the method comprising administering a compound disclosed herein to the subject, or contacting the biological sample with a compound disclosed herein.

[0411] In ...

Claims

1. A compound of formula I: TLC(I) Or its pharmaceutically acceptable salts, solvates or stereoisomers, wherein: C has the formula I-1' （I-1'）， in: Indicates connection to L; B 1 It is CR B1 Or N; B 3 It is CR B3 Or N; B 4 It is CR B4 Or N; B 5 It is CR B5 Or N; B 6 It is C or N; R B1 R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 A carbocyclic or 3- to 5-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; X does not exist; it is O, S, or NR. X ; R X It is hydrogen, C 1-3 Alkyl, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R D1 Is it hydrogen, deuterium, or carbon? 1-6 alkyl; Each R D Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, d is an integer from 0 to 6; and q is an integer between 0 and 2. T has: i) Formula I-3-i (I-3-i), in: E 1 yes CR E1 Or N; E 2 yes CR E2 Or N; E 3 yes CR E3 Or N; Indicates connection to L; R E1 R E2 R E3 and R E4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 1 It is C or N; F 2 It is NR F2' or CR F2 ; R F2' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; F 3 It is CR F3 , N or NR F3' ; R F3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F3' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R F4 It is -C(=O)NR 3a R 3b Or optionally by one or more R u The substituted 5- to 6-membered heteroaryl groups; and R 3a and R 3b Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or R 3a and R 3b Together with the nitrogen atom to which it is attached, it forms a 3- to 12-membered heterocycle or a 5- to 10-membered heteroaryl group, wherein the heterocycle or heteroaryl group is optionally connected by one or more R groups. u replace, ii) Formula I-3-ii (I-3-ii), in: G 1 yes , N or CR G1 ; G 2 yes , N or CR G2 ; G 3 yes , N or CR G3 ; Indicates connection to L; R G1 R G2 R G3 and R G4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; H 1 It is C(R) H1 2. NR H1' Or O; H 2 It is C(R) H2 2. NR H2' Or O; R H1 and R H2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs H1 Or two Rs H2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u Replace; and R H1' and R H2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace, iii) Equation I-3-iii (I-3-iii), in: Indicates connection to L; I 1 It is C(R) I1 2. NR I1' Or O; I 2 It is C(R) I2 2. NR I2' Or O; R I1 and R I2 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs I1 Or two Rs I2 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; R I1' and R I2' Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic groups, 3- to 6-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, carbocyclic, or heterocyclic group is optionally surrounded by one or more R groups. u replace; Each R I Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; i is an integer selected from 0 to 4; J 1 Is it N or CR? J1 ; J 2 Is it N or CR? J2 ;and R J1 R J2 and R J3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace, iv) Formula I-3-iv (I-3-iv), in: M 1 It is N or C; M 2 yes , , N or CR M2 ; M 3 yes , , N or CR M3 ; M 4 yes , , N or CR M4 ; in Indicates connection with L; and M 1 M 2 M 3 and M 4 At least one of them is N or ; R M2 R M3 and R M4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R K' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; K 1 Is it -C(=O)- or -C(R)? K1 )2-; Each R K1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R K Independently, it is oxo, hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and k is an integer selected from 0 to 4; v) Formula I-3-v (I-3-v), in: P 1 yes , , N or CR P1 ; P 2 yes , , N or CR P2 ; Indicates connection to L; Each R N Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; n is an integer selected from 0 to 6; R P1 R P2 and R P3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; and R 4 It is -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace, or vi) Formula I-3-vi (I-3-vi), in: Q 1 It is NR Q1' C(R) Q1 )2 or O; R Q1' It is hydrogen, C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; Each R Q1 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q1 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; when If it is a double bond, then Q 2 Is it N or CR? Q2 And Q 3 Is it N or CR? Q3 ; when If it is a single key, then Q 2 It is NR Q2' C(R) Q2 )2 or O; Q 3 It is NR Q3' C(R) Q3 )2 or O; R Q2' and R Q3' Independently, it is hydrogen and C 1-6 Alkyl, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-membered heteroaryl, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; R Q2 and R Q3 Each time it appears, it is independently hydrogen, halogen, -CN, -NO2, -OH, -NH2, C. 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u Replace; or Two Rs Q2 Or two Rs Q3 Together with the carbon atom it is attached to, it forms C 3-6 A carbon ring or a 3- to 6-membered heterocycle, wherein the carbon ring or heterocycle is optionally surrounded by one or more R u replace; S 1 It is CR S1 Or N; S 2 yes CR S2 Or N; S 3 yes CR S3 Or N; S 4 yes CR S4 Or N; Indicates connection with L; and R S1 R S2 R S3 and R S4 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 Aryl, 5- to 10-member heteroaryl, -SR b -S(=O)R a -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -NR c S(=O)2R a -NR c S(=O)R a -NR c S(=O)2OR b -NR c S(=O)2NR c R d -NR b C(=O)NR c R d -NR b C(=O)R a -NR b C(=O)OR b -OS(=O)2R a -OS(=O)2OR b -OS(=O)2NR c R d -OC(=O)R a -OC(=O)OR b -OC(=O)NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d The alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace; L has the formula I-2'' （I-2''）， in: Indicates a connection to C; Cy 1 yes ， in: Indicates a connection to T; T 1 It is CR T1 Or N; V 1 It is CR V1 Or N; V 2 It is CR V2 Or N; R T1 R V1 and R V2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R T Independently, it is a halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, t is an integer selected from 0 to 6; or Cy 1 yes ， in: when When it is a double bond, then Y 1 It is C; when When it is a single bond, then Y 1 Is it N or CR? Y1 ; Indicates a connection to T; R Y1 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Y 2 It is C(R) Y2 )2, O or N(R) Y2' ); Each R Y2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; R Y2' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbocyclic groups, 3- to 4-membered heterocyclic groups, -S(=O)2R a -S(=O)2OR b -S(=O)2NR c R d -C(=O)R a -C(=O)OR b or -C(=O)NR c R d ; Z 1 It is CR Z1 Or N; Z 2 It is CR Z2 Or N; R Z1 and R Z2 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; Each R Z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; When valence is allowed, z is an integer selected from 0 to 6. Where R Z It can exist on ring Y or ring Z; Cy 2 It is a C6 arylene or a 5- to 6-membered heteroarylene, wherein the arylene or heteroarylene is optionally surrounded by one or more R u replace; L 2 It is CH2 or CH(C) 1-3 Alkyl); and L 3 It is an E-vinylene, ethynylene, C6 arylene, or 5- to 6-heteroarylene, wherein the E-vinylene, arylene, or heteroarylene is optionally surrounded by one or more R u replace; in: Each R u Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 6-membered heterocyclic groups; Each R a C is independent 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; Each R b Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; and Each R c and R d Independently, it is hydrogen and C 1-6 Alkyl, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups; or R c and R d Together with the nitrogen atom it is attached to, it forms a 3- to 6-membered heterocyclic group. Where R a R b R c and R d Each time it appears, it is independently and optionally controlled by one or more R... z Replace; and Each R z Independently, it is oxo, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-6 Carbocyclic or 3- to 6-membered heterocyclic groups The condition is that the compound of formula I is no or .

2. The compound according to claim 1, wherein C has the formula I-1-i, I-1-ii, or I-1-iii. (I-1-i), (I-1-ii) or (I-1-iii).

3. The compound according to claim 2, wherein B 1 B 3 B 4 and B 5 None of them are N; or B 1 and B 5 One of them is N.

4. The compound according to claim 3, wherein C has the formula I-1-i-1', I-1-i-2', I-1-i-3, I-1-ii-1, I-1-ii-2, I-1-ii-3, I-1-iii-1, I-1-iii-2 or I-1-iii-3. (I-1-i-1'), (I-1-i-2'), (I-1-i-3) (I-1-ii-1) (I-1-ii-2) (I-1-ii-3) (I-1-iii-1) (I-1-iii-2) (I-1-iii-3).

5. The compound according to any one of claims 2 to 4, wherein R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 Or R B3 R B4 and R B5 Independently, it is oxo, hydrogen, halogen, -CN, -OH, C 1-6 Alkyl, C 1-6 Haloalkyl, C 1-6 Alkoxy or C 1-6 Alkylamino.

6. The compound according to claim 5, wherein R B1 R B3 R B4 and R B5 R B1 R B3 and R B4 Or R B3 R B4 and R B5 Independently, it is hydrogen, halogen, or C. 1-6 alkyl.

7. The compound according to any one of claims 1 to 6, wherein T has the formula I-3-ii (I-3-ii)。 8. The compound according to claim 7, wherein T has the formula I-3-ii-a (I-3-ii-a).

9. The compound according to claim 6 or 7, wherein G 1 It is CR G1 And G 3 Is it N or CR? G3 , where R G1 and R G3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

10. The compound according to claim 9, wherein R G1 and R G3 Each of them is hydrogen.

11. The compound according to any one of claims 7 to 10, wherein R G4 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

12. The compound according to claim 11, wherein R G4 It is hydrogen, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 Alkenyl or 3- to 12-membered heterocyclic group, wherein the alkyl, alkoxy, alkylamino, alkenyl or heterocyclic group is optionally surrounded by one or more R u replace.

13. The compound according to any one of claims 7 to 12, wherein H 1 It is NR H1' And H 2 It is NR H2' , where R H1' and R H2' Independently hydrogen or C 1-6 alkyl.

14. The compound according to any one of claims 1 to 6, wherein T has the formula I-3-iv (I-3-iv).

15. The compound according to claim 14, wherein T has the formula I-3-iv-a (I-3-iv-a)。 16. The compound according to claim 14 or 15, wherein K 1 It is -C(=O)-.

17. The compound according to any one of claims 14 to 16, wherein M 1 M 3 and M 4 At least two of them are N.

18. The compound according to any one of claims 14 to 17, wherein M 1 M 3 and M 4 At least one of them is N.

19. The compound according to any one of claims 14 to 18, wherein M 3 It is N.

20. The compound according to any one of claims 14 to 18, wherein M 3 It is CR M3 , where R M3 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

21. The compound according to claim 14, wherein T has the formula I-3-iv-b (I-3-iv-b).

22. The compound according to any one of claims 14 to 21, wherein each R K Independently hydrogen or C 1-6 alkyl.

23. The compound according to any one of claims 14 to 22, wherein R K' Is it hydrogen or C? 1-6 alkyl.

24. The compound according to any one of claims 14 to 23, wherein R M2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

25. The compound according to any one of claims 1 to 6, wherein T has the formula I-3-vi 。 26. The compound according to claim 25, wherein T has the formula I-3-vi-a or I-3-vi-b. (I-3-vi-a) or (I-3-vi-b).

27. The compound according to claim 25 or 26, wherein R S2 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

28. The compound according to any one of claims 25 to 27, wherein R S4 It is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

29. The compound according to any one of claims 25 to 28, wherein Q 1 It is NR Q1' , where R Q1' Is it hydrogen or C? 1-6 alkyl.

30. The compound according to any one of claims 25 to 29, wherein It is a double bond, and Q 2 Is it N or CR? Q2 And Q 3 It is CR Q3 , where R Q2 and R Q3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbon cyclic group or 3- to 4-membered heterocyclic group.

31. The compound according to claim 30, wherein R Q2 and R Q3 Independently hydrogen or C 1-6 alkyl.

32. The compound according to any one of claims 25 to 31, wherein If it's a single key, then Q 2 It is C(R) Q2 )2 and Q 3 It is NR Q3' or C(R) Q3 )2, where each R Q2 and R Q3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 3-4 Carbocyclic or 3- to 4-membered heterocyclic groups; and R Q3' It is hydrogen, C 1-6 Alkyl, C 3-4 Carbon cyclic group or 3- to 4-membered heterocyclic group.

33. The compound according to claim 32, wherein each R Q2 Is it hydrogen or C? 1-6 Alkyl, and R Q3' It is C 1-6 Alkyl groups, and each R Q2 and R Q3 Independently hydrogen or C 1-6 alkyl.

34. The compound according to any one of claims 25 to 33, wherein S 1 It is CR S1 And S 3 It is CR S3 , where R S1 and R S3 Independently, it is hydrogen, halogen, -CN, -NO2, -OH, -NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Alkylamino, C 2-6 alkenyl, C 2-6 alkynyl group, C 3-12 Carbocyclic groups, 3- to 12-membered heterocyclic groups, C 6-10 aryl or 5- to 10-membered heteroaryl, wherein the alkyl, alkoxy, alkylamino, alkenyl, alkynyl, carbocyclic, heterocyclic, aryl, or heteroaryl group is optionally surrounded by one or more R groups. u replace.

35. The compound according to any one of claims 1 to 34, wherein Cy 1 yes 。 36. The compound according to claim 35, wherein V 1 It is N.

37. The compound according to claim 35 or 36, wherein T 1 It is CR T1 And V 2 It is CR V2 , where R T1 and R V2 It is hydrogen.

38. The compound according to claim 37, wherein Cy 1 yes 。 39. The compound according to any one of claims 1 to 38, wherein Cy 1 yes 。 40. The compound according to claim 39, wherein Cy 1 yes 。 41. The compound according to any one of claims 1 to 40, wherein Cy 2 It is optionally influenced by one or more halogens, C 1-6 Alkyl or C 1-6 Alkoxy-substituted pyridyl group, wherein the C 1-6 Alkyl groups are optionally surrounded by one or more C groups. 1-6 Alkyl-substituted.

42. The compound according to claim 41, wherein Cy 2 yes , , , , , , , , or , Where ## represents Cy 1 connect.

43. The compound according to any one of claims 1 to 42, wherein L 2 It is CH2.

44. The compound according to any one of claims 1 to 43, wherein L 3 It is E-vinylidene, ethynylene, or 1,4-phenylene.

45. A compound selected from the compounds in Tables 1-3, or pharmaceutically acceptable salts thereof.

46. ​​A pharmaceutical composition comprising a compound according to any one of claims 1 to 45, and a pharmaceutically acceptable excipient.

47. A method for degrading proteins in a subject or a biological sample, the method comprising administering a compound according to any one of claims 1 to 45 to the subject, or contacting the biological sample with a compound according to any one of claims 1 to 45.

48. Use of a compound according to any one of claims 1 to 45 for the preparation of a medicament for degrading proteins in a subject or biological sample.

49. The compound according to any one of claims 1 to 45, used for degrading proteins in a subject or biological sample.

50. The method, use, or compound for use according to any one of claims 47 to 49, wherein the protein is p300 or CBP.

51. A method of treating p300-mediated conditions, the method comprising administering to a patient in need a compound according to any one of claims 1 to 45.

52. Use of a compound according to any one of claims 1 to 45, for the preparation of a medicament for treating p300-mediated conditions.

53. The compound according to any one of claims 1 to 45, for treating p300-mediated conditions.

54. The method, use, or compound for use according to any one of claims 51 to 53, wherein the p300-mediated condition is cancer, an inflammatory condition, or an autoimmune disease.

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