High-integration visual self-adaptive polarization regulation noninvasive blood glucose measuring device and high-integration visual self-adaptive polarization regulation noninvasive blood glucose measuring method

Abstract

The invention relates to a non-invasive blood glucose measuring device and method, in particular to a high-integration visual self-adaptive polarization regulation and control non-invasive blood glucose measuring device and method, and solves the technical problems that an existing non-invasive blood glucose measuring device based on polarization regulation and control is complex in integration, high in cost, poor in polarization self-adaptability and low in measuring precision. Reflected polarized light of subcutaneous blood vessels of a to-be-detected part of a human body is detected and imaged through the visual imaging module, light intensity information is obtained, the light passing quantity of the integrated self-adaptive polarizer module and the integrated self-adaptive polarization analyzer module is adjusted according to the light intensity information, and therefore the light intensity is adjusted and controlled in a self-adaptive mode; the problems of overexposure of a high-brightness scene and difficulty in imaging of a low-brightness scene in an actual complex environment can be avoided; meanwhile, the integrated self-adaptive polarizer module and the integrated self-adaptive analyzer module can realize high-degree-of-freedom time-sharing work of incident polarized light in different polarization states, so that self-adaptive regulation and control of various polarization states are realized.

Description

Technical Field

[0001] This invention relates to a non-invasive blood glucose measurement device and method, specifically to a highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device and method. Background Technology

[0002] The Mueller matrix optical rotation method is an optical measurement method that can effectively measure the polarization optical signals of chaotic biological tissues in the human body. Because it can avoid the problems of high background noise and severe signal stacking and crossover in traditional infrared non-invasive blood glucose measurement methods, it has great development potential in the field of non-invasive blood glucose measurement.

[0003] The non-invasive blood glucose measurement device based on the Mueller matrix optical rotation method calculates the Mueller matrix of human skin tissue by adjusting the polarization state of the incident and reflected light. Then, by decomposing the Mueller matrix, physical quantities such as optical rotation angle and degree of polarization are calculated. Based on the relationship between physical quantities such as optical rotation angle and degree of polarization and glucose concentration, non-invasive blood glucose measurement can be achieved. Currently, there are numerous studies on non-invasive blood glucose measurement using the Mueller matrix optical rotation method. For example, Chinese patent CN118806275A discloses a non-invasive blood glucose measurement device and method that uses an electronic control module to control the polarization of a liquid crystal. The electronic control module's synchronous triggering of the detector enables real-time detection of the polarization state. This device boasts high control precision, simple structure, and small size. Chinese patent CN117179753A discloses a portable non-invasive blood glucose measurement device that achieves non-invasive blood glucose measurement by rationally arranging polarization initiation and detection devices from top to bottom. Chinese patent CN101133960A discloses a non-invasive blood glucose measurement device using orthogonal dual-polarized light, which converts the measured blood glucose signal into a signal intensity difference between two polarization directions, enabling continuous blood glucose measurement. All of the above non-invasive blood glucose measurement devices employ polarization control devices, which are the core components of Mueller matrix optical rotation non-invasive blood glucose measurement devices. These devices typically use mechanical motor control or liquid crystal electronic control to regulate the polarization state. However, the mechanical motor control method has large errors and cannot meet the accuracy requirements of non-invasive blood glucose measurement. On the other hand, the liquid crystal electronic control method usually requires additional temperature control equipment, which is bulky, expensive, and complex to control, making it difficult to meet the high integration requirements of non-invasive blood glucose measurement devices.

[0004] The complex, multi-layered structure of human skin tissue, coupled with the fact that blood glucose levels are hidden within the capillaries of the dermis beneath the surface skin, presents significant challenges for non-invasive blood glucose measurement. Existing non-invasive blood glucose measurement devices typically rely on large-angle scattered light imaging technology, which suffers from significant distortion and weak signals, easily leading to misjudgments and false readings. Furthermore, these devices require sophisticated imaging chips, resulting in high costs. Simultaneously, the varying reflectivity of different skin colors (such as dark, fair, and yellow) causes substantial measurement errors at the detection end, hindering the achievement of adaptive non-invasive blood glucose measurement for a large number of diabetic patients.

[0005] Furthermore, the non-invasive blood glucose measurement device based on the Mueller matrix optical rotation method of polarization state modulation fails to fully consider the process tolerance of the integrated polarization device fabrication, resulting in a large measurement error and making it difficult to meet the high precision requirements of non-invasive blood glucose measurement. Summary of the Invention

[0006] The purpose of this invention is to solve the technical problems of existing polarization-modulated non-invasive blood glucose measurement devices, such as complex integration, high cost, poor adaptability, and low measurement accuracy, and to provide a highly integrated, visualized, adaptive polarization-modulated non-invasive blood glucose measurement device and method.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A highly integrated, visual, adaptive polarization-controlled, non-invasive blood glucose measurement device is characterized by the following features: a light source module for generating a detection beam, an integrated adaptive polarizer module and an integrated adaptive analyzer module each comprising N polarization channels, a visual imaging module, a detector module, an electronic control module, and a data processing module, wherein N is an integer and N≥4; The integrated adaptive polarizer module is set in the transmission optical path of the detection beam to adaptively adjust the polarization state and light intensity of the detection beam, generate incident polarized light, and focus it on the part of the human body to be tested. The visualization imaging module is located at the center of the integrated adaptive polarizer module, and its output end is connected to the input end of the data processing module. It is used to detect and image the reflected polarized light of subcutaneous blood vessels in the human body to be tested, and obtain subcutaneous blood vessel imaging information. The integrated adaptive polarizer module and detector module are sequentially arranged along the transmission optical path of the reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested. The integrated adaptive polarizer module is used to adaptively adjust the polarization state and light intensity of the reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested, so as to obtain N×N combinations of polarization state combinations of reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested. The output end of the detector module is connected to the input end of the data processing module, and is used to detect and image the reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested with N×N combinations of polarization state combinations, so as to obtain glucose polarization information with N×N combinations of polarization state combinations. The output of the data processing module is connected to the input of the electronic control module. The data processing module is used to analyze and process subcutaneous vascular imaging information to obtain light intensity information, and to analyze and process glucose polarization information of N×N polarization state combinations to obtain blood glucose concentration. The output terminal of the electronic control module is connected to the trigger terminals of the visualization imaging module and the detector module, as well as the control terminals of the integrated adaptive polarizer module and the integrated adaptive analyzer module. It is used to send trigger signals to the visualization imaging module and the detector module, and to regulate the polarization state channel and light transmission of the integrated adaptive polarizer module and the integrated adaptive analyzer module.

[0008] Furthermore, the integrated adaptive polarizer module includes a first integrated polarizer and a first integrated adaptive polarizer; The first integrated polarizer and the first integrated adaptive are arranged sequentially along the optical path of the detection beam, and a visualization imaging module is set at the center of the first integrated adaptive; or, the first integrated polarizer and the first integrated adaptive are arranged sequentially in reverse of the optical path of the detection beam, and a visualization imaging module is set at the center of the first integrated polarizer. The first integrated polarizer includes N polarization state channels for adjusting the polarization state of the detection beam; the control terminal of the first integrated adaptive is connected to the output terminal of the electronic control module for adaptively adjusting the light intensity of the detection beam and selecting the polarization state channels of the first integrated polarizer. The integrated adaptive polarizer module includes a second integrated polarizer and a second integrated adaptive polarizer. The second integrated polarizer and the second integrated adaptive polarizer are arranged sequentially along the reflected polarized light transmission path of glucose in the subcutaneous blood vessels of the human body to be tested, or sequentially in the opposite direction to the reflected polarized light transmission path of glucose in the subcutaneous blood vessels of the human body to be tested. The second integrated polarizer includes N polarization state channels, which are used to regulate the polarization state of the reflected polarized light of glucose in subcutaneous blood vessels at the human test site, so as to obtain N×N combinations of polarization state of the reflected polarized light of glucose in subcutaneous blood vessels at the human test site; the control terminal of the second integrated adaptive is connected to the output terminal of the electronic control module, which is used to adaptively regulate the light intensity of the reflected polarized light of glucose in subcutaneous blood vessels at the human test site, and to select the polarization state channels of the second integrated polarizer.

[0009] Furthermore, the first integrated polarizer includes N first polarization elements uniformly distributed in a ring structure, each first polarization element being a polarization state channel for generating incident polarized light of a polarization state. The first integrated adaptive includes N first adaptive control elements respectively set corresponding to N first polarization elements. The control terminal of each first adaptive control element is connected to the output terminal of the electronic control module. The electronic control module is used to select a first adaptive control element so that the incident polarized light generated by the first polarization element corresponding to the first adaptive control element can pass through, and at the same time adjust the light transmission of the first adaptive control element, thereby controlling the intensity of the incident polarized light. The second integrated polarizer includes N second polarization elements uniformly distributed in a ring structure. Each second polarization element is a polarization state channel used to obtain reflected polarized light of glucose in subcutaneous blood vessels at the human test site with a combination of polarization states. The second integrated adaptive unit includes N second adaptive control elements, each corresponding to one of the N second polarization elements. The control terminal of each second adaptive control element is connected to the output terminal of the electronic control module. The electronic control module is used to select one second adaptive control element, allowing the reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site, which is obtained by the second polarization element corresponding to the second adaptive control element, to pass through. At the same time, the light transmission of the second adaptive control element is adjusted, thereby controlling the light intensity of the reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site, which is obtained by the polarization state combination.

[0010] Furthermore, the detector module is an array detector or a single-point detector.

[0011] Furthermore, N=4, the four first polarization units are respectively a 0-degree linearly polarized light unit, a 45-degree linearly polarized light unit, a 90-degree linearly polarized light unit, and a right-hand circularly polarized light unit; the four second polarization units are respectively a 0-degree linearly polarized light unit, a 45-degree linearly polarized light unit, a 90-degree linearly polarized light unit, and a right-hand circularly polarized light unit.

[0012] Alternatively, N=6, where the 6 first polarization units are respectively a 0-degree linearly polarized light unit, a 45-degree linearly polarized light unit, a 90-degree linearly polarized light unit, a 135-degree linearly polarized light unit, a right-hand circularly polarized light unit, and a left-hand circularly polarized light unit; and the 6 second polarization units are respectively a 0-degree linearly polarized light unit, a 45-degree linearly polarized light unit, a 90-degree linearly polarized light unit, a 135-degree linearly polarized light unit, a right-hand circularly polarized light unit, and a left-hand circularly polarized light unit.

[0013] Furthermore, the adjustment period of the integrated adaptive polarizer module is 1 / N of that of the integrated adaptive analyzer module.

[0014] Furthermore, the light source module includes a light source and a coupling lens disposed in the light source emission direction, wherein the light beam generated by the light source is collimated and parallel to the detection light beam by the coupling lens; The first adaptive control unit and the second adaptive control unit are electrically controlled apertures, electrically controlled liquid crystal optical switches, or electrically controlled choppers. The visualization imaging module is a micro-area array detector chip.

[0015] This invention also provides a highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement method, employing the aforementioned highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device. Its unique feature lies in the inclusion of the following steps: Step A1: Send a trigger signal to the visualization imaging module and the detector module through the electronic control module to start the visualization imaging module and the detector module. Step A2: Turn on the light source module to generate a detection beam that is incident on the integrated adaptive polarizer module. The integrated adaptive polarizer module adjusts the detection beam and focuses it on the part of the human body to be tested. Step A3: The visualization imaging module detects and images the reflected polarized light of the subcutaneous blood vessels in the area to be tested on the human body, obtains subcutaneous blood vessel imaging information, and sends it to the data processing module. Step A4: The data processing module analyzes and processes the subcutaneous vascular imaging information to obtain light intensity information, and sends it to the electronic control module; Step A5: Based on the light intensity information, the electronic control module adjusts the light transmittance of the integrated adaptive polarizer module and the integrated adaptive analyzer module, thereby adaptively controlling the light intensity. Simultaneously, the electronic control module adjusts the polarization state channels of the integrated adaptive polarizer module and the integrated adaptive analyzer module, ensuring that each module is in one of the N polarization state channels, forming N×N polarization state combinations. Then, the detector module detects the reflected polarized light of glucose from subcutaneous blood vessels at the test site for each polarization state combination, obtaining glucose polarization information for the N×N polarization state combinations, and sending it to the data processing module. The glucose polarization information is obtained through the following steps: Step A5.1: The integrated adaptive polarizer module adjusts the polarization state of the detection beam to generate incident polarized light and focuses it onto the part of the human body to be tested. Step A5.2: The integrated adaptive polarization analyzer module receives the reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested, and modulates its polarization state to obtain the reflected polarized light of glucose in the subcutaneous blood vessels of the human body to be tested, which is a combination of polarization states. Step A5.3: The detector module detects and images the reflected polarized light of glucose in the subcutaneous blood vessels of the human body at the test site, and obtains the glucose polarization information of the polarization state combination. Step A6: The data processing module analyzes and processes the glucose polarization information of N×N polarization state combinations to obtain the blood glucose concentration, thus realizing non-invasive blood glucose measurement.

[0016] The present invention also provides another highly integrated visual adaptive polarization-controlled non-invasive blood glucose measurement device, which is characterized by: including a light source module for generating a detection beam, an integrated adaptive polarizer module including M polarization state channels, an integrated adaptive polarization detection imaging module including M polarization imaging channels, an electronic control module and a data processing module, wherein M is an integer and M≥4; The integrated adaptive polarizer module is set in the transmission optical path of the detection beam to adaptively adjust the polarization state and light intensity of the detection beam, generate incident polarized light, and focus it on the part of the human body to be tested. The integrated adaptive polarization detection imaging module is located at the center of the integrated adaptive polarizer module, and includes an integrated adaptive polarizer module and a detector module that are sequentially integrated along the optical path of the reflected light transmission light from the part of the human body to be tested. The integrated adaptive polarization analyzer module is used to adaptively adjust the polarization state and intensity of the reflected light from the human body test site, obtaining M×M combinations of polarization state reflected light from the human body test site; the output end of the detector module is connected to the input end of the data processing module, used to detect and image the polarized light reflected from subcutaneous blood vessels in the reflected light from the human body test site, to obtain subcutaneous blood vessel imaging information, and to detect and image the polarized light reflected from glucose in subcutaneous blood vessels in the reflected light from the human body test site with M×M combinations of polarization state, to obtain glucose polarization information with M×M combinations of polarization state. The output of the data processing module is connected to the input of the electronic control module, and is used to analyze and process the subcutaneous vascular imaging information to obtain light intensity information, and to analyze and process the glucose polarization information of M×M polarization state combinations to obtain blood glucose concentration. The output terminal of the electronic control module is connected to the trigger terminal of the detector module, the control terminal of the integrated adaptive polarizer module, and the control terminal of the integrated adaptive analyzer module, respectively, and is used to send trigger signals to the detector module and adjust the polarization state channel and light transmission of the adaptive polarizer module and the integrated adaptive analyzer module.

[0017] This invention also provides another highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement method, employing the aforementioned highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device, characterized by the following steps: Step B1: Send a trigger signal to the detector module through the electronic control module to start it working; Step B2: Turn on the light source module to generate a detection beam that is incident on the integrated adaptive polarizer module. The integrated adaptive polarizer module adjusts the detection beam and focuses it on the part of the human body to be tested. Step B3: The detector module detects and images the polarized light reflected from the subcutaneous blood vessels in the reflected light of the body part to be tested, obtains subcutaneous blood vessel imaging information, and sends it to the data processing module. Step B4: The data processing module analyzes and processes the subcutaneous vascular imaging information to obtain light intensity information, and sends it to the electronic control module. Step B5: Based on the light intensity information, the electronic control module adjusts the light transmittance of the integrated adaptive polarizer module and the integrated adaptive analyzer module, thereby adaptively controlling the light intensity. Simultaneously, the electronic control module adjusts the polarization state channels of the integrated adaptive polarizer module and the integrated adaptive analyzer module, ensuring that each module is in one of the M polarization state channels, forming M×M polarization state combinations. Then, the detector module detects the reflected glucose polarization light from the subcutaneous blood vessels in each polarization state combination, obtaining glucose polarization information for the M×M polarization state combinations, and sending it to the data processing module. The glucose polarization information is obtained through the following steps: Step B5.1: The integrated adaptive polarizer module adjusts the polarization state of the detection beam to generate incident polarized light and focuses it onto the part of the human body to be tested. Step B5.2: The integrated adaptive analyzer module receives the polarized light reflected from the subcutaneous blood vessels of glucose in the reflected light from the human body test site, and modulates its polarization state to obtain the polarized light reflected from the subcutaneous blood vessels of glucose in the reflected light from the human body test site with a combination of polarization states. Step B5.3: The detector module detects and images the polarized light reflected from the subcutaneous blood vessels in the reflected light of the human body's test site in the polarization state combination, and obtains the glucose polarization information of the polarization state combination. Step B6: The data processing module analyzes and processes the glucose polarization information of the M×M polarization state combinations to obtain the blood glucose concentration, thus realizing non-invasive blood glucose measurement.

[0018] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention provides a highly integrated, visually adaptive, polarization-controlled non-invasive blood glucose measurement device. It uses a visual imaging module to detect and image the reflected polarized light from subcutaneous blood vessels at the test site, obtaining light intensity information. Based on this information, the light transmittance of the integrated adaptive polarizer module and the integrated adaptive analyzer module is adjusted, thereby adaptively controlling the light intensity. This avoids the problems of overexposure in high-brightness scenes and difficulty in imaging in low-brightness scenes under complex real-world environments. Simultaneously, by using an electronic control module to regulate the polarization state channels of the integrated adaptive polarizer module and the integrated adaptive analyzer module, high-degree-of-freedom time-division operation of incident polarized light with different polarization states can be achieved, thus realizing adaptive control of multiple polarization states. 2. The present invention provides a highly integrated visual adaptive polarization-controlled non-invasive blood glucose measurement device, which adopts a highly integrated adaptive polarizer module and an integrated adaptive polarizer module. It can avoid the problems of large error and complex control of traditional mechanical motor control method and liquid crystal electronic control method for controlling polarization state, and the need for external equipment, resulting in large size and high cost. It can realize highly integrated and convenient integrated control of multiple polarization states. 3. The present invention provides a highly integrated visual adaptive polarization-controlled non-invasive blood glucose measurement device. The integrated adaptive polarizer module and the integrated adaptive polarizer module are both cascaded and integrated polarizers and integrated adaptive polarizers. The positions of the integrated polarizers and integrated adaptive polarizers are interchangeable, and the structure is simple and easy to integrate. 4. The present invention provides a highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement method that combines high-precision non-invasive blood glucose measurement with visual imaging non-invasive blood glucose measurement. It fully considers the small-angle reflected light imaging of subcutaneous blood vessels at the test site and the optical information characteristics of glucose molecules in subcutaneous blood vessels. By using a visual imaging module set in the incident light path and a detector module set in the reflected light path, it can simultaneously meet the development needs of visualization and high precision in non-invasive blood glucose measurement. 5. The present invention provides a highly integrated, visual, adaptive polarization-controlled, non-invasive blood glucose measurement method. By using a visual imaging module, it avoids the problems of large distortion, weak signal, complex system, easy misjudgment and mismeasurement, and excessive requirements and high cost of imaging chips in traditional large-angle scattered light imaging by imaging the reflection of subcutaneous blood vessels at a small angle in the human body. This improves the visual imaging quality of subcutaneous blood vessels at the human body. 6. Another highly integrated visual adaptive polarization-controlled non-invasive blood glucose measurement device provided by the present invention sets the integrated adaptive polarization detection imaging module at the center of the integrated adaptive polarizer module, replacing the visual imaging module. This enables integrated common-path control detection of glucose polarization information in N×N polarization state combinations, further reducing the device size, simplifying the number of components, and lowering costs. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the structure of the highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device according to Embodiment 1 of the present invention; Figure 2 This is a schematic diagram of the structure of the integrated adaptive polarizer module and visualization imaging module in Embodiment 1 of the present invention; Figure 3 This is a schematic diagram of the structure of the highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device according to Embodiment 2 of the present invention; Figure 4 This is a schematic diagram of the structure of the highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device according to Embodiment 3 of the present invention (the electronic control module and data processing module are not shown). Figure 5 This is a schematic diagram of the integrated adaptive polarization detection imaging module in Embodiment 3 of the present invention; The annotations in the attached figures are explained as follows: 1-Light source module, 2-Integrated adaptive polarizer module, 3-Human body part to be measured, 4-Visualization imaging module, 5-Integrated adaptive polarizer module, 6-Detector module, 7-Electronic control module, 8-Data processing module, 9-Light source, 10-Coupled lens, 11-First integrated polarizer, 12-First integrated adaptive polarizer, 13-Second integrated polarizer, 14-Second integrated adaptive polarizer, 15-Integrated adaptive polarization detection imaging module. Detailed Implementation

[0020] The highly integrated, visual, adaptive polarization-controlled, non-invasive blood glucose measurement device and method proposed in this invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. Those skilled in the art should understand that these embodiments are merely used to explain the technical principles of this invention and are not intended to limit the scope of protection of this invention.

[0021] Example 1 A highly integrated, visual, adaptive polarization-controlled, non-invasive blood glucose measurement device, such as Figure 1 As shown, it includes a light source module 1 for generating a detection beam, an integrated adaptive polarizer module 2 and an integrated adaptive analyzer module 5, each with 6 polarization channels, as well as a visualization imaging module 4, a detector module 6, an electronic control module 7, and a data processing module 8.

[0022] An integrated adaptive polarizer module 2 is positioned in the transmission optical path of the detection beam to adaptively adjust the polarization state and intensity of the detection beam, generating incident polarized light and focusing it onto the human body's test site 3. A visualization imaging module 4 is positioned at the center of the integrated adaptive polarizer module 2, with its output connected to the input of the data processing module 8. It is used to detect and image the reflected polarized light from the subcutaneous blood vessels at the test site 3, obtaining subcutaneous blood vessel imaging information. The visualization imaging module 4 enables small-angle reflected light imaging of the subcutaneous blood vessels at the test site 3, thereby achieving high-precision visualization and positioning for non-invasive blood glucose measurement. This avoids problems such as large distortion, system complexity, weak signal, and misjudgment and false detection associated with large-angle scattered light imaging, improving the visualization imaging quality of the subcutaneous blood vessels at the test site 3.

[0023] An integrated adaptive analyzer module 5 and a detector module 6 are sequentially arranged along the transmission optical path of the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3. The integrated adaptive analyzer module 5 is used to adaptively adjust the polarization state and intensity of the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3, obtaining 6×6 combinations of polarization state combinations of the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3. The output end of the detector module 6 is connected to the input end of the data processing module 8, and is used to detect and image the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3 with 6×6 combinations of polarization state, obtaining glucose polarization information for 6×6 combinations of polarization state.

[0024] The output of data processing module 8 is connected to the input of electronic control module 7. Data processing module 8 is used to analyze and process subcutaneous vascular imaging information to obtain light intensity information, and to analyze and process glucose polarization information of 6×6 polarization state combinations to obtain blood glucose concentration. The output of electronic control module 7 is connected to the trigger terminals of visualization imaging module 4 and detector module 6, and the control terminals of integrated adaptive polarizer module 2 and integrated adaptive analyzer module 5, respectively. It is used to send trigger signals to visualization imaging module 4 and detector module 6, and to adjust the polarization state channels and light transmission of integrated adaptive polarizer module 2 and integrated adaptive analyzer module 5.

[0025] The light source module 1 includes a light source 9 and a coupling lens 10 disposed in the emission direction of the light source 9. The light beam generated by the light source 9 passes through the coupling lens 10 to form a collimated and parallel detection light beam.

[0026] like Figure 2 As shown, the integrated adaptive polarizer module 2 includes a first integrated polarizer 11 and a first integrated adaptive polarizer 12, which are arranged sequentially along the detection beam transmission optical path. A visualization imaging module 4 is positioned at the center of the first integrated adaptive polarizer 12. In other embodiments, the first integrated polarizer 11 and the first integrated adaptive polarizer 12 are arranged sequentially in reverse of the detection beam transmission optical path, with the visualization imaging module 4 positioned at the center of the first integrated polarizer 11. The first integrated polarizer 11 includes six polarization state channels for controlling the polarization state of the detection beam. The control terminal of the first integrated adaptive polarizer 12 is connected to the output terminal of the electronic control module 7, and is used to adaptively control the light intensity of the detection beam and select the polarization state channels of the first integrated polarizer 11. The integrated adaptive polarizer module 2 modulates the collimated and parallel detection beam into incident polarized light with different polarization states along its transmission direction through the first integrated polarizer 11, and adjusts the light transmission through the first integrated adaptive polarizer 12 to achieve adaptation to different spatial light intensities. This avoids the problems of overexposure in high-brightness scenes and difficulty in imaging in low-brightness scenes in actual complex environments. At the same time, by selecting the polarization state channel of the first integrated polarizer 11 through the first integrated adaptive polarizer 12, it can realize high degree of freedom time-division operation of incident polarized light with different polarization states, thereby realizing adaptive control of multiple polarization states.

[0027] The first integrated polarizer 11 includes six first polarization elements uniformly distributed in a ring structure. Each first polarization element is a polarization state channel used to generate incident polarized light of a certain polarization state. The six first polarization elements are a 0-degree linearly polarized light element, a 45-degree linearly polarized light element, a 90-degree linearly polarized light element, a 135-degree linearly polarized light element, a right-hand circularly polarized light element, and a left-hand circularly polarized light element. The first integrated adaptive unit 12 includes six first adaptive control elements corresponding to the six first polarization elements. The control terminal of each first adaptive control element is connected to the output terminal of the electronic control module 7. The electronic control module 7 is used to select one first adaptive control element, allowing the incident polarized light generated by the corresponding first polarization element to pass through, and simultaneously adjusting the light transmission of the first adaptive control element, thereby controlling the intensity of the incident polarized light.

[0028] The integrated adaptive polarizer module 5 has the same structure as the integrated adaptive polarizer module 2, including a second integrated polarizer 13 and a second integrated adaptive polarizer 14. The second integrated polarizer 13 and the second integrated adaptive polarizer 14 are sequentially arranged along the optical path of the reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3. In other embodiments, the second integrated polarizer 13 and the second integrated adaptive polarizer 14 are sequentially arranged against the beam transmission direction along the optical path of the reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3. The second integrated polarizer 13 includes 6 polarization state channels, used to regulate the polarization state of the reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3, obtaining 6×6 combinations of polarization state combinations of reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3. The control terminal of the second integrated adaptive polarizer 14 is connected to the output terminal of the electronic control module 7, used to adaptively regulate the intensity of the reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3, and to select the polarization state channel of the second integrated polarizer 13.

[0029] The second integrated polarizer 13 includes six second polarization elements uniformly distributed in a ring structure. Each second polarization element is a polarization state channel used to obtain the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3, which represents a combination of polarization states. The six second polarization elements are a 0-degree linearly polarized light element, a 45-degree linearly polarized light element, a 90-degree linearly polarized light element, a 135-degree linearly polarized light element, a right-handed circularly polarized light element, and a left-handed circularly polarized light element. The second integrated adaptive unit 14 includes six second adaptive control elements corresponding to the six second polarization elements. The control terminal of each second adaptive control element is connected to the output terminal of the electronic control module 7. The electronic control module 7 is used to select one second adaptive control element, allowing the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3, which represents a combination of polarization states, to pass through. Simultaneously, it adjusts the light transmission of the second adaptive control element, thereby controlling the intensity of the reflected polarized light of glucose from the subcutaneous blood vessels of the human body test site 3, which represents a combination of polarization states.

[0030] In this embodiment, the adjustment period of the first integrated adaptive unit 12 is 1 / 6 of the adjustment period of the second integrated adaptive unit 14. For each type of incident polarized light generated by the integrated adaptive polarizer module 2, the integrated adaptive analyzer module 5 adaptively adjusts and selects 6 polarization state channels respectively, so as to obtain 6×6 combinations of polarization state combinations of reflected polarized light from glucose in the subcutaneous blood vessels of the human body test site 3. The detector module 6 is a single-point detector, and the first and second adaptive adjustment units are electrically controlled apertures, electrically controlled liquid crystal optical switches, or electrically controlled choppers. The visualization imaging module 4 is a micro-array detector chip.

[0031] This embodiment also provides a highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement method, employing the aforementioned highly integrated, visual, adaptive polarization-controlled non-invasive blood glucose measurement device, including the following steps: Step 1: Send a trigger signal to the visualization imaging module 4 and the detector module 6 through the electronic control module 7 to start the visualization imaging module 4 and the detector module 6.

[0032] Step 2: Turn on the light source module 1 to generate a detection beam that is incident on the integrated adaptive polarizer module 2. The integrated adaptive polarizer module 2 adjusts the detection beam and focuses it onto the human body part to be tested 3.

[0033] Step 3: The visualization imaging module 4 detects and images the reflected polarized light of the subcutaneous blood vessels in the human body's test site 3, obtains subcutaneous blood vessel imaging information, and sends it to the data processing module 8.

[0034] Step 4: The data processing module 8 analyzes and processes the subcutaneous vascular imaging information to obtain light intensity information, and sends it to the electronic control module 7.

[0035] Step 5: Based on the light intensity information, the electronic control module 7 adjusts the light transmission of the integrated adaptive polarizer module 2 and the integrated adaptive analyzer module 5, thereby adaptively controlling the light intensity. Simultaneously, the electronic control module 7 adjusts the polarization state channels of the integrated adaptive polarizer module 2 and the integrated adaptive analyzer module 5, placing them in the polarization states corresponding to the six polarization state channels, forming 6×6 polarization state combinations. Then, the detector module 6 detects the reflected polarized light of glucose in the subcutaneous blood vessels of the human body's test site 3 for each polarization state combination, obtaining glucose polarization information for the 6×6 polarization state combinations, and sending it to the data processing module 8. The glucose polarization information is obtained through the following steps: Step 5.1: The integrated adaptive polarizer module 2 adjusts the polarization state of the detection beam to generate incident polarized light and focuses it onto the human body part to be tested 3. Step 5.2: The integrated adaptive polarization analyzer module 5 receives the reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site 3, and modulates its polarization state to obtain the reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site 3 with a combination of polarization states. Step 5.3: Detector module 6 detects and images the reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site 3, which is a combination of polarization states, to obtain the glucose polarization information of the combination of polarization states.

[0036] In step 5, the integrated adaptive polarizer module 2 uses the first integrated adaptive polarizer 12 to select the incident polarized light generated by the first integrated polarizer 11, and sequentially controls the generation of 6 polarization states of incident polarized light and focuses it onto the human body test site 3; for each type of incident polarized light generated by the integrated adaptive polarizer module 2, the integrated adaptive analyzer module 5 adaptively controls and sequentially selects 6 polarization state channels to obtain 6×6 combinations of polarization state combinations of reflected polarized light of glucose in the subcutaneous blood vessels of the human body test site 3.

[0037] Step 6: The data processing module 8 analyzes and processes the glucose polarization information of 6×6 polarization state combinations to obtain the blood glucose concentration, thus realizing non-invasive blood glucose measurement.

[0038] The glucose polarization information for the 6×6 polarization state combinations obtained in step 5 is shown in Table 1.

[0039] Table 1 In Table 1, I x,yThe detected glucose polarization information is represented by x, where x represents the polarization state of the polarization state channel selected by the integrated adaptive polarizer module 2, and y represents the polarization state of the polarization state channel selected by the integrated adaptive analyzer module 5. By combining the glucose polarization information of 6×6 polarization state combinations, the Mueller matrix of the human body test site 3 can be obtained, and then the blood glucose concentration can be calculated. The specific calculation process is as follows: The Mueller matrix M of the human body part to be tested 3 is: Based on the glucose polarization information of the 6×6 polarization state combinations in Table 1, we can obtain: Then, based on the differential Mueller matrix theory or decomposition theory, the optical rotation angle γ produced by the blood glucose optical rotation effect is calculated, and the blood glucose concentration can be obtained.

[0040] Example 2 The difference between this embodiment and Embodiment 1 is that the detector module 6 uses an area array detector, which can simultaneously detect and image the reflected polarized light of glucose in the subcutaneous blood vessels of the human body's test site 3, which has six different polarization states. For example... Figure 3As shown, detector module 6 includes six detector elements, each corresponding to one of the six second polarization elements. For each type of incident polarized light generated by integrated adaptive polarizer module 2, the six polarization state channels of integrated adaptive analyzer module 5 are simultaneously selected, generating six combinations of polarization state reflected polarized light from the subcutaneous blood vessels of the human body test site 3. Detector module 6 performs area array detection imaging on this light, obtaining glucose polarization information for all six polarization state combinations in a single measurement. Furthermore, through six adjustments to the first integrated adaptive polarizer 12 in integrated adaptive polarizer module 2, glucose polarization information for all six polarization state combinations is obtained in six measurements, thereby improving blood glucose measurement efficiency.

[0041] Example 3 like Figure 4 , Figure 5 As shown, based on Embodiment 2, this embodiment integrates the integrated adaptive polarizer module 5 and the detector module 6 into an integrated adaptive polarization detection imaging module 15, and replaces the visualization imaging module 4 at the center of the integrated adaptive polarizer module 2. The function of the visualization imaging module 4 is implemented by the detector module 6, which can realize integrated common-path control detection of glucose polarization information with 6×6 polarization state combinations, further reducing the size of the device, simplifying the number of components, and reducing costs.

[0042] like Figure 4 As shown, the detection beam generated by the light source module 1 is incident on the integrated adaptive polarizer module 2. The integrated adaptive polarizer module 2 adaptively adjusts and generates incident polarized light, which is then focused onto the human body part to be tested 3. The detector module 6 in the integrated adaptive polarization detection and imaging module 15 detects and images the small-angle polarized light reflected from subcutaneous blood vessels and the large-angle polarized light reflected from glucose within subcutaneous blood vessels in the reflected light from the human body part to be tested 3. The proportion of glucose polarized light reflected from subcutaneous blood vessels at the large angle is much greater than that at the small angle. To avoid the subcutaneous blood vessel polarized light being overwhelmed in the reflected light from the human body part to be tested 3, the imaging proportion of glucose polarized light reflected from subcutaneous blood vessels in the reflected light from the human body part to be tested 3 can be adjusted to achieve high-precision visual positioning imaging of the subcutaneous blood vessels in the human body part to be tested 3. The ratio of polarized light reflected from subcutaneous blood vessels to polarized light reflected from glucose in subcutaneous blood vessels in the reflected light of the human body test site 3 is adjusted by the spatial distance between the integrated adaptive polarization detection imaging module 15 and the integrated adaptive polarizer module 2. The farther the integrated adaptive polarization detection imaging module 15 is from the integrated adaptive polarizer module 2, the stronger the signal of polarized light reflected from glucose in subcutaneous blood vessels in the reflected light of the human body test site 3.

Claims

1. A highly integrated, visual, adaptive polarization-controlled, non-invasive blood glucose measurement device, characterized in that: The application relates to a noninvasive blood glucose monitoring system, which comprises a light source module (1) for generating a detection light beam, an integrated adaptive polarizer module (2) and an integrated adaptive analyzer module (5) each comprising N polarization state channels, a visual imaging module (4), a detector module (6), an electric control module (7) and a data processing module (8), wherein N is an integer and N>=4. The integrated adaptive polarizer module (2) is arranged on a transmission light path of the detection light beam and is used for adaptively regulating the polarization state and the light intensity of the detection light beam, generating incident polarized light and focusing on a human body part to be measured (3). The visual imaging module (4) is arranged at a central position of the integrated adaptive polarizer module (2) and is connected with an input end of the data processing module (8), and is used for detecting and imaging the reflected polarized light of subcutaneous blood vessels of the human body part to be measured (3) to obtain subcutaneous blood vessel imaging information. The integrated adaptive analyzer module (5) and the detector module (6) are sequentially arranged along a transmission light path of the reflected polarized light of glucose in subcutaneous blood vessels of the human body part to be measured (3), the integrated adaptive analyzer module (5) is used for adaptively regulating the polarization state and the light intensity of the reflected polarized light of glucose in subcutaneous blood vessels of the human body part to be measured (3) to obtain N*N kinds of polarization state combinations of the reflected polarized light of glucose in subcutaneous blood vessels of the human body part to be measured (3), and the output end of the detector module (6) is connected with the input end of the data processing module (8) and is used for detecting and imaging N*N kinds of polarization state combinations of the reflected polarized light of glucose in subcutaneous blood vessels of the human body part to be measured (3) to obtain N*N kinds of polarization state combinations of glucose polarization information. The output end of the data processing module (8) is connected with the input end of the electric control module (7), the data processing module (8) is used for analyzing and processing the subcutaneous blood vessel imaging information to obtain light intensity information and analyzing and processing N*N kinds of polarization state combinations of glucose polarization information to obtain blood glucose concentration. The output end of the electric control module (7) is connected with the trigger end of the visual imaging module (4) and the detector module (6) and the control end of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) respectively, and is used for sending trigger signals to the visual imaging module (4) and the detector module (6) and regulating the polarization state channels and light transmittance of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5).

2. The highly integrated visual adaptive polarization modulation noninvasive blood glucose measurement device according to claim 1, characterized in that: The integrated adaptive polarizer module (2) comprises a first integrated polarizer (11) and a first integrated adapter (12). The first integrated polarizer (11) and the first integrated adapter (12) are sequentially arranged along the transmission light path of the detection light beam, the visual imaging module (4) is arranged at a central position of the first integrated adapter (12); or the first integrated polarizer (11) and the first integrated adapter (12) are sequentially arranged along the transmission light path of the detection light beam in reverse, and the visual imaging module (4) is arranged at a central position of the first integrated polarizer (11). The first integrated polarizer (11) comprises N polarization state channels for regulating the polarization state of the detection beam; the control end of the first integrated adapter (12) is connected with the output end of the electric control module (7), for adaptively regulating the light intensity of the detection beam and selecting the polarization state channel of the first integrated polarizer (11); The integrated adaptive polarimeter module (5) comprises a second integrated polarizer (13) and a second integrated adapter (14), which are arranged in sequence along the transmission path of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3) or in reverse sequence. The second integrated polarizer (13) comprises N polarization state channels for regulating the polarization state of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3), obtaining N×N polarization state combinations of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3); the control end of the second integrated adapter (14) is connected with the output end of the electric control module (7), for adaptively regulating the light intensity of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3) and selecting the polarization state channel of the second integrated polarizer (13).

3. The highly integrated visual adaptive polarization-governed noninvasive blood glucose measurement device according to claim 2, characterized in that: The first integrated polarizer (11) comprises N first polarization elements uniformly distributed in a ring structure, each first polarization element being a polarization state channel for generating incident polarized light of one polarization state; The first integrated adapter (12) comprises N first adaptive regulation elements corresponding to the N first polarization elements, respectively; the control end of each first adaptive regulation element is connected with the output end of the electric control module (7), respectively; the electric control module (7) is used for selecting one first adaptive regulation element, so that the incident polarized light generated by the first polarization element corresponding to the first adaptive regulation element passes through, and simultaneously adjusts the light transmittance of the first adaptive regulation element, thereby regulating the light intensity of the incident polarized light; The second integrated polarizer (13) comprises N second polarization elements uniformly distributed in a ring structure, each second polarization element being a polarization state channel for obtaining one polarization state combination of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3); The second integrated adapter (14) comprises N second adaptive regulation elements corresponding to the N second polarization elements, respectively; the control end of each second adaptive regulation element is connected with the output end of the electric control module (7), respectively; the electric control module (7) is used for selecting one second adaptive regulation element, so that the one polarization state combination of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3) obtained by the second polarization element corresponding to the second adaptive regulation element passes through, and simultaneously adjusts the light transmittance of the second adaptive regulation element, thereby regulating the light intensity of the one polarization state combination of the reflected polarized light of the subcutaneous blood vessel glucose of the human body to be measured (3).

4. The highly integrated visual adaptive polarization-governed noninvasive blood glucose measurement device according to claim 3, characterized in that: The detector module (6) is a face array detector or a single point detector.

5. The highly integrated visual adaptive polarization-gated non-invasive blood glucose measurement device of claim 4, wherein: N=4, the four first polarization elements are respectively 0-degree linearly polarized light element, 45-degree linearly polarized light element, 90-degree linearly polarized light element and right circularly polarized light element; the four second polarization elements are respectively 0-degree linearly polarized light element, 45-degree linearly polarized light element, 90-degree linearly polarized light element and right circularly polarized light element; Or, N=6, the six first polarization elements are respectively 0-degree linearly polarized light element, 45-degree linearly polarized light element, 90-degree linearly polarized light element, 135-degree linearly polarized light element, right circularly polarized light element and left circularly polarized light element; the six second polarization elements are respectively 0-degree linearly polarized light element, 45-degree linearly polarized light element, 90-degree linearly polarized light element, 135-degree linearly polarized light element, right circularly polarized light element and left circularly polarized light element.

6. The highly integrated visual adaptive polarization-gated non-invasive blood glucose measurement device of claim 5, wherein: The control period of the integrated adaptive polarizer module (2) is 1 / N of the integrated adaptive analyzer module (5).

7. The highly integrated visual adaptive polarization-gated non-invasive blood glucose measurement device of claim 6, wherein: The light source module (1) comprises a light source (9) and a coupling lens (10) arranged in the emission direction of the light source (9), and the light beam generated by the light source (9) forms a collimated parallel detection light beam through the coupling lens (10); The first adaptive control element and the second adaptive control element are electrically controlled diaphragms, electrically controlled liquid crystal optical switches or electrically controlled choppers; The visual imaging module (4) is a macro face array detector chip.

8. A high-integration visual adaptive polarization regulation noninvasive blood glucose measurement method, using the high-integration visual adaptive polarization regulation noninvasive blood glucose measurement device of any one of claims 1-7, characterized in that, The method comprises the following steps: Step A1, sending a trigger signal to the visual imaging module (4) and the detector module (6) through the electric control module (7) to start the work of the visual imaging module (4) and the detector module (6); Step A2, turning on the light source module (1) to generate a detection light beam incident to the integrated adaptive polarizer module (2), and the integrated adaptive polarizer module (2) focuses the detection light beam to the human body part to be measured (3) after control; Step A3, the visual imaging module (4) detects and images the reflected polarized light of the subcutaneous blood vessels of the human body part to be measured (3) to obtain subcutaneous blood vessel imaging information and sends it to the data processing module (8); Step A4, the data processing module (8) analyzes and processes the subcutaneous blood vessel imaging information to obtain light intensity information and sends it to the electric control module (7); Step A5, the electric control module (7) controls the light intensity of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) according to the light intensity information, and at the same time, the electric control module (7) controls the polarization state channel of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) to make the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) respectively in the polarization state corresponding to N polarization state channels, form N×N polarization state combinations, and then use the detector module (6) to detect the reflected polarized light of the subcutaneous blood vessels of the human body part to be measured (3) in each polarization state combination to obtain N×N polarization state combination glucose polarization information and send it to the data processing module (8); wherein, the glucose polarization information is obtained by the following steps: Step A5.1, the integrated adaptive polarizer module (2) regulates the polarization state of the detection beam, generates incident polarized light, and focuses it to the human body to be measured (3); Step A5.2, the integrated adaptive analyzer module (5) receives the reflected polarized light of the glucose in the subcutaneous blood vessels of the human body to be measured (3), and regulates its polarization state to obtain the reflected polarized light of the glucose in the subcutaneous blood vessels of the human body to be measured (3) with polarization state combination; Step A5.3, the detector module (6) detects and images the reflected polarized light of the glucose in the subcutaneous blood vessels of the human body to be measured (3) with polarization state combination to obtain the glucose polarization information with polarization state combination; Step A6, the data processing module (8) analyzes and processes the glucose polarization information with N×N polarization state combinations to obtain the blood glucose concentration, realizing non-invasive blood glucose measurement.

9. A high-integration visual adaptive polarization regulation non-invasive blood glucose measurement device, characterized in that: It comprises a light source module (1) for generating a detection beam, an integrated adaptive polarizer module (2) comprising M polarization state channels, an integrated adaptive polarization detection imaging module (15) comprising M polarization imaging channels, and an electric control module (7) and a data processing module (8), wherein M is an integer and M≥4; The integrated adaptive polarizer module (2) is arranged on the transmission light path of the detection beam, and is used for adaptively regulating the polarization state and light intensity of the detection beam, generating incident polarized light, and focusing to the human body to be measured (3); The integrated adaptive polarization detection imaging module (15) is arranged at the center position of the integrated adaptive polarizer module (2), and comprises an integrated adaptive analyzer module (5) and a detector module (6) integrated in turn along the transmission light path of the reflected light of the human body to be measured (3); The integrated adaptive analyzer module (5) is used for adaptively regulating the polarization state and light intensity of the reflected light of the human body to be measured (3), and obtaining M×M polarization state combinations of the reflected light of the human body to be measured (3) respectively; The output end of the detector module (6) is connected with the input end of the data processing module (8), and is used for detecting and imaging the subcutaneous blood vessel reflected polarized light in the reflected light of the human body to be measured (3) to obtain subcutaneous blood vessel imaging information, and detecting and imaging the subcutaneous blood vessel glucose reflected polarized light in the M×M polarization state combinations of the reflected light of the human body to be measured (3) to obtain M×M polarization state combination glucose polarization information; The output end of the data processing module (8) is connected with the input end of the electric control module (7), and is used for analyzing and processing the subcutaneous blood vessel imaging information to obtain light intensity information, and analyzing and processing the M×M polarization state combination glucose polarization information to obtain the blood glucose concentration; The output end of the electric control module (7) is connected with the trigger end of the detector module (6), the control end of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) respectively, and is used for sending a trigger signal to the detector module (6), and regulating the polarization state channel and light transmission amount of the adaptive polarizer module (2) and the integrated adaptive analyzer module (5).

10. A high-integration visual adaptive polarization regulation noninvasive blood glucose measurement method, using the high-integration visual adaptive polarization regulation noninvasive blood glucose measurement device of claim 9, characterized in that, It comprises the following steps: Step B1, the electric control module (7) sends a trigger signal to the detector module (6) to start working; Step B2, open the light source module (1), produce the incident detection beam to the integrated adaptive polarizer module (2), the integrated adaptive polarizer module (2) is focused to the human body to be measured part (3) after regulating the detection beam; Step B3, the detector module (6) detects the subcutaneous blood vessel reflected polarized light in the human body to be measured part (3) reflected light, obtains the subcutaneous blood vessel imaging information, and sends to the data processing module (8); Step B4, the data processing module (8) analyzes and processes the subcutaneous blood vessel imaging information, obtains the light intensity information, and sends to the electric control module (7); Step B5, the electric control module (7) regulates the light intensity of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) according to the light intensity information; At the same time, the electric control module (7) regulates the polarization state channel of the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5), so that the integrated adaptive polarizer module (2) and the integrated adaptive analyzer module (5) are respectively in the polarization state corresponding to the M polarization state channels, MxM polarization state combinations are formed, then the detector module (6) is used to detect the subcutaneous blood vessel glucose reflected polarized light in the human body to be measured part (3) reflected light of each polarization state combination, MxM polarization state combination glucose polarization information is obtained, and is sent to the data processing module (8); Wherein, the glucose polarization information is obtained by the following steps: Step B5.1, the integrated adaptive polarizer module (2) regulates the polarization state of the detection beam, generates incident polarized light, and focuses it to the human body to be measured part (3); Step B5.2, the integrated adaptive analyzer module (5) receives the subcutaneous blood vessel glucose reflected polarized light in the human body to be measured part (3) reflected light, and regulates the polarization state, obtains the subcutaneous blood vessel glucose reflected polarized light in the human body to be measured part (3) reflected light of the polarization state combination; Step B5.3, the detector module (6) detects the subcutaneous blood vessel glucose reflected polarized light in the human body to be measured part (3) reflected light of the polarization state combination, and obtains the polarization state combination glucose polarization information; Step B6, the data processing module (8) analyzes and processes the MxM polarization state combination glucose polarization information, obtains the blood glucose concentration, and realizes the noninvasive blood glucose measurement.

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