Platelet-rich plasma centrifugal device and centrifugal method

Abstract

The platelet-rich plasma centrifugal device comprises a centrifugal support body, a first positioning part and a second positioning part are movably arranged on the centrifugal support body, and a fixing part is arranged on the centrifugal support body; the fixing part fixes a needle head of a blood taking needle, the second positioning part fixes a needle body of the blood taking needle, and the first positioning part fixes a piston of the blood taking needle.

Description

Technical Field

[0001] This invention belongs to the field of medical devices, and particularly relates to PRP treatment devices. Background Technology

[0002] Platelet-rich plasma (PRP) is a concentrated platelet extract obtained from the patient's own blood through centrifugation. It contains various growth factors and proteins, such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF-1). These growth factors can induce and regulate cell division, differentiation, and proliferation, accelerate the natural healing process of tissues, and also have antibacterial and pain-relieving effects. Minimally invasive PRP therapy uses a concentrate extracted from the patient's own blood, containing high concentrations of platelets, growth factors, and various repair cells. Because it originates from the patient's own blood, there is no risk of immune rejection or disease transmission, making it safe and reliable. When injected into the damaged site, it can awaken the tissue's self-repair capabilities, promote cell regeneration and inflammation reduction, thereby relieving pain and improving function.

[0003] PRP can be applied to cartilage damage repair, tendon degeneration repair, and fracture healing promotion, such as early and mid-stage osteoarthritis, osteochondral damage, meniscus injury, partial rotator cuff injury, promoting healing after rotator cuff repair surgery, lateral epicondylitis of the humerus, tendinopathy and other degenerative diseases of tendon insertion points, and promoting the healing of bone nonunion.

[0004] The clinical application of PRP treatment involves several steps: Step 1: Blood collection: A certain amount of whole blood (about 20-50 ml of venous blood, depending on the brand) is drawn from the patient's vein and added to a tube containing an anticoagulant.

[0005] Step 2: Centrifuge using specialized equipment at specific speeds and times: Centrifuge the whole blood containing the anticoagulant. The initial centrifugation is generally performed at 4000-6000 rpm, forming three layers: The upper layer is platelet-rich plasma (PPP). The middle layer is the platelet-rich layer (PRP). The bottom layer consists of red blood cells.

[0006] Transfer layers: Remove the top PPP and the middle PRP and transfer them to another sterile test tube.

[0007] Secondary centrifugation: The transferred liquid is centrifuged a second time, usually at 2400 rpm, to further separate and concentrate the PRP.

[0008] Save PRP: After completion, extract the PRP from the middle layer for subsequent medical applications.

[0009] Step 3: "Precision Injection". Doctors will use imaging equipment such as ultrasound to locate the damaged knee joint and ensure that platelet-rich plasma is accurately injected into key areas such as cartilage damage and synovitis.

[0010] Chinese patent document CN202421936893.6, "A Device for Preparing Platelet-Rich Plasma," discloses a device comprising an intermediate sleeve, an upper storage body, an upper storage cover, a lower storage body, and a lower storage cover. Hyperbolic PRP channels and red blood cell channels are respectively arranged within the upper and lower storage bodies. Two locking bolts are fixed inside the intermediate sleeve. When the upper locking bolt engages with the PRP channel, the upper storage body and upper storage cover form a PRP storage chamber. When the lower locking bolt engages with the red blood cell channel, the lower storage body and lower storage cover form a red blood cell storage chamber. The intermediate sleeve serves as the plasma storage chamber. A PRP aspiration port is provided on the upper storage cover, allowing for accurate extraction of the desired amount of PRP through a needle via the aspiration port. This invention provides a blood separation device that enables two centrifugal separations without exposing the blood to air, resulting in high blood concentration and precise PRP extraction.

[0011] However, the device has a complex structure and is not reusable, making it difficult to reduce the medical costs for patients.

[0012] Chinese patent document CN202422746108.7, entitled "A preparation apparatus for a blood cell-containing platelet-rich plasma suspension and gel", discloses: a fixing frame, at least one quick-clamping tube clamp mounted on the fixing frame, a vacuum centrifuge tube clamped in the quick-clamping tube clamp, two aspirators that can be inserted into the centrifuge tube from the top or bottom, a pusher for pushing the aspirators into the centrifuge tube, and a rotating mechanism for driving the pusher to rotate so that the aspirators face the top or bottom of the centrifuge tube.

[0013] This technology solves the problems of blood contamination, human error, and low extraction rate that are common in existing technologies during manual operation, and can better utilize the functional effects of various components in the blood. However, the device has a complex structure and relatively low efficiency in actual use.

[0014] Chinese patent documents CN202422533028.3, "A PRP Extraction Device Rich in Leukocytes," and CN202422537411.6, "A PRP Extraction Device for Leukocyte-Depleted Cells," both disclose a centrifuge tube and cap that interlock. The centrifuge tube, from top to bottom, comprises a first chamber, a second chamber, and a third chamber that are sequentially connected. In use, the extraction device is first set vertically upright, centrifuged, and then rotated 180° for a second centrifugation.

[0015] Chinese patent document CN202411464203.6, "A method for extracting leukocyte-rich PRP based on a leukocyte-rich PRP extraction device," discloses: S1, Set the extraction device vertically in the forward direction; S2, inject the collected blood sample into centrifuge tube 1; S3, start the centrifuge, control the centrifugal force and time of the centrifuge to perform the first centrifugation, so that the blood sample is separated into red blood cell layer, white blood cell layer and plasma layer from bottom to top; S4. Slowly rotate the base 5 to move the piston 4 downwards; S5. Slowly rotate the knob cap 63 to control the boundary between the red blood cell layer and the white blood cell layer to always be located at the bottom of the second cavity 13. S6, rotate the extraction device 180° for a second centrifugation; S7. After inserting syringe A into the bottom of cap 2, collect the concentrated platelets, white blood cells and plasma.

[0016] Chinese patent document CN202411658380.8, "A PRP Preparer and a PRP Preparation Method," discloses a tube body, an upper cover, a lower cover, and a sealing plug. The tube body includes an upper section, a middle section, and a lower section. The upper cover cooperates with the upper section to form an upper cavity. The upper cover can be moved up and down to switch between a first position and a second position. The upper cover is provided with an injection / absorption hole, an aspiration tube, and a sealing element. The lower cover cooperates with the lower section to form a lower cavity. The lower cover can be moved up and down to adjust the volume of the lower cavity. The sealing plug is used to control the opening and closing of the injection / absorption hole and the aspiration tube. The portion of the aspiration tube located in the upper cavity has a set length. This set length allows the aspiration tube to be located within the platelet-rich plasma layer in the second position and maintain a distance from the platelet-rich plasma layer, and allows the port of the aspiration tube to be located outside the platelet-rich plasma layer in the first position. Applying this application allows for direct adjustment of the PRP concentration within the preparer and avoids damage to platelets during PRP extraction.

[0017] Chinese patent document CN202411244951.3, entitled "A Platelet-Rich Plasma Preparer and Its Preparation Method," discloses: S01: Blood is injected into the cap at the plasma injection port of the injection needle; S02: Prepare the counterweight using another platelet-rich plasma preparation device; S03: Place the platelet-rich plasma preparation device containing blood into a medical centrifuge for the first centrifugation; S04: Take out the platelet-rich plasma preparation device containing blood while it is upright, turn the red blood cell compartment cover counterclockwise, and push the PRP into the PPP storage chamber; S05: The inclined opening of the first drive block pushes the red blood cell locking rod downward, and the sealing end of the red blood cell locking rod seals and locks the first tube, and tightens the rubber cap at the vent. S06: Gently shake the white film layer and clear liquid, invert the preparation device, screw on the PRP chamber cap, set the PRP preparation volume, invert the preparation device and place it in the medical centrifuge to start the second centrifugation; S07: After the second centrifugation, remove the preparation device and keep it in a vertical position. Press the second drive block so that the inclined opening of the second drive block pushes the PRP locking rod downwards, and the sealing column end of the PRP locking rod seals and locks the second tube. S08: Shake gently, tear off the aluminum foil seal on the PRP compartment cover, insert the syringe into the silicone cover to extract the PRP from the PRP storage compartment.

[0018] Chinese patent document CN202411019834.7, "Automated PRP Preparation System of Multiple Specifications," discloses a system consisting of three parts: centrifuge tubes, extraction consumables, and a centrifuge. It adopts a direct-push design instead of a rotary design, significantly simplifying the liquid level adjustment components, reducing structural complexity and assembly difficulty, and improving system stability and reliability. It also introduces a leukocyte filtration function to ensure the quality of the prepared PRP product and reduce the risk of adverse transfusion reactions in patients after treatment in certain situations. Furthermore, it optimizes the centrifugation component structure to ensure accurate centrifuge tube repositioning and improve reliability. Finally, it optimizes the equipment's appearance and overall design, enhancing user experience and ease of operation.

[0019] Chinese patent document CN202110219376.1, "A centrifuge tube and a PRP extraction method using the centrifuge tube," discloses: a centrifuge tube has a chamber, in which a first piston, a second piston, and a flexible connecting tube are provided. The first piston and the second piston divide the chamber into a first cavity, a second cavity, and a third cavity in sequence. Each cavity has a first connection port and a second connection port communicating with the outside. The first piston has a third connection port. The flexible connecting tube is located in the first cavity, with one end connected to the first connection port and the other end connected to the third connection port. The flexible connecting tube is used to connect the second cavity with the outside, and the second connection port is used to connect the third cavity with the outside. The centrifuge tube has a first plug and a second plug, with the first plug used to seal the first connection port and the second plug used to seal the second connection port.

[0020] Chinese patent document CN202411097692.6, "A Device for Preparing Platelet-Rich Plasma," discloses a device comprising an intermediate sleeve, an upper storage body, an upper storage cover, a lower storage body, and a lower storage cover. Hyperbolic PRP channels and red blood cell channels are respectively arranged within the upper and lower storage bodies. Two locking bolts are fixed inside the intermediate sleeve. When the upper locking bolt engages with the PRP channel, the upper storage body and upper storage cover form a PRP storage chamber. When the lower locking bolt engages with the red blood cell channel, the lower storage body and lower storage cover form a red blood cell storage chamber. The intermediate sleeve serves as the plasma storage chamber. A PRP aspiration port is provided on the upper storage cover, allowing for accurate extraction of the required amount of PRP through a needle via the aspiration port. This invention provides a blood separation device capable of performing two centrifugal separations without exposing the blood to air.

[0021] Chinese patent document CN202511056341.5, "A High-Purity P-PRP Preparation System and Preparation Method Thereof," discloses: a sterile syringe for sampling, a centrifuge for centrifugation, a centrifuge sleeve, and a separator for purifying the sample from the centrifuged sterile syringe; the centrifuge sleeve is of two types, including an inverted centrifuge sleeve for the first centrifugation and an upright centrifuge sleeve for the second centrifugation. The preparation method includes steps such as sample preparation, first centrifugation, purification and re-sampling, second centrifugation, and final sampling, ultimately obtaining high-purity leukocyte-depleted platelet-rich plasma. This invention's system and method allow conventional medical syringes to be directly used in closed centrifuge sleeves, effectively solving the problem of contact with the outside environment during transfer and centrifugation, reducing the risk of contamination during PRP preparation, facilitating P-PRP extraction, avoiding the impact of liquid adhering to the wall on purity, improving purity, and preventing residual contamination.

[0022] Chinese patent document CN201310539497.X, entitled "A Method and Apparatus for Separating and Extracting Platelet-Rich Blood," discloses a method and apparatus for separating and extracting platelet-rich blood using a medical syringe. The method involves drawing venous blood into a device, separating the blood using a single device, and finally extracting the desired platelet cells for later use. The device, from top to bottom, includes a PRP storage chamber, a plasma storage chamber, a locking lever handle, and a red blood cell storage chamber. This invention overcomes the shortcomings of traditional platelet-rich blood separation and extraction methods, such as the use of multiple tools, inconvenience, and susceptibility to contamination. It features a simple structure, convenient operation, and allows the entire blood separation process to be completed within a single device.

[0023] Chinese patent document CN201810004218.2, entitled "Platelet-Rich Plasma Separation Device and Separation Method," discloses: a blood collection tube, a three-way connector, a syringe, a long needle assembly, and a third and fourth rubber stopper with an air filter. The blood collection tube has an upward-opening cavity and a first rubber stopper covering the opening. The three-way connector has a first port and a second port that are interconnected, and a coarse needle that can be inserted through the first rubber stopper. The syringe includes a syringe barrel with a third port. The long needle assembly includes a needle tube, a connecting sleeve, and a second rubber stopper. The needle tube has a first end and a second end. The second end is inserted through the connecting sleeve and the second rubber stopper in sequence, and the first end protrudes from the connecting sleeve in a direction away from the second end.

[0024] Chinese patent document CN202122617471.5, entitled "An Inverted Centrifuge Sleeve for Closed-Type P-PRP Preparation," discloses: a centrifuge sleeve and a sealing cap, wherein the centrifuge sleeve includes a sleeve body, a fixing seat disposed inside the sleeve, a device for retrieving from the upper wall of the sleeve body, and a fixing device on the top inner side of the sealing cap; the centrifuge sleeve is hollow to form a receiving cavity for accommodating the sample, and a fixing seat is disposed at the bottom of the receiving cavity; the inner wall of the sealing cap and the upper end of the centrifuge sleeve form a detachable sealing structure; a coupling post is disposed on the top of the fixing seat, the size of which matches the bottom of the plunger of the syringe containing the sample to be tested; the fixing device disposed on the top inner side of the sealing cap matches the end seal of the syringe containing the sample to be tested.

[0025] The devices disclosed in the above patent documents can all simplify the operation process and reduce the risk of contamination. However, these devices are all specialized equipment, and whether they are reused repeatedly by sterilization or purchased multiple times for single use, they all require high operating costs.

[0026] In addition to the methods disclosed in the patent documents, such as inverted or 180° rotation centrifugation, medical personnel still need to transfer platelet-rich plasma to a special device or perform one or more extractions using a needle. The plasma is then transferred from a dedicated device to a syringe for clinical application. The complexity of the process, the issue of contact with the external environment, and the risk of infection remain.

[0027] Chinese patent document CN202320776445.3, "A Centrifugal Separation Tube Kit for Platelet-Rich Plasma Preparation," discloses a centrifugal sleeve and four sets of centrifugal tubes. The centrifugal sleeve includes a sleeve body and a first sealing cap, which is threaded onto the sleeve body. A groove is provided on the upper outer wall of the sleeve body. In summary, this utility model differs from the prior art by adopting an inverted placement, which makes the separation more thorough during the separation process. Furthermore, the head of the centrifugal syringe is fixed in the syringe fixing groove to prevent it from shaking during centrifugation and affecting the centrifugal structure. Moreover, the injection head of the centrifugal syringe is equipped with a sterile medical three-way valve, which can effectively avoid sample contamination during sampling, sample transfer, and centrifugation, resulting in higher sample safety and accuracy.

[0028] This invention reduces the risk of contamination during the preparation of raw fluids such as blood, and lowers the cost of clinical use.

[0029] However, in actual use, this technical solution requires medical staff to disassemble and reassemble the needle multiple times, and the exposure of the needle also poses a high risk of infection.

[0030] Chinese patent document CN202111464524.2, "A centrifuge for PRP extraction," discloses: a casing with an internal centrifugation chamber, a motor and control main board mounted on the casing, and a rotor. The depth of the centrifugation chamber is greater than the length of the syringe used for blood extraction. A mounting frame is fixedly fitted onto the rotor. Multiple centrifuge tube adapters for installing syringes are detachably pivotally connected to the top of the mounting frame. These adapters are arranged radially symmetrically and at equal intervals along the circumference of the mounting frame. The distance between two symmetrical adapters is greater than the length of the syringe plunger that matches the centrifuge tube adapter. When the adapter is rotated to a horizontal position, the distance from its pivot point with the mounting frame to the wall of the centrifugation chamber is greater than the length of the empty syringe barrel. The casing is also equipped with a scanning device for controlling the start of the motor.

[0031] The patented technical solution does not require damaging the syringe; the needle is directly centrifuged to ensure the stability of PRP extraction and avoid PRP contamination.

[0032] However, the problem with this device is that, on the one hand, it cannot solve the infection risk associated with exposed needles; on the other hand, the device does not reinforce or protect the needle tube, and in actual use, problems such as needle tube breakage and piston failure may occur under high-speed centrifugation conditions.

[0033] Chinese patent document CN202322060950.0, entitled "A Simple Apparatus for Preparing Platelet-Rich Plasma," discloses a centrifuge container comprising a centrifuge tube, a piston, a liquid injection head, and an infusion tube. The piston is slidably inserted inside one end of the centrifuge tube, and the liquid injection head is located outside the other end of the centrifuge tube. The infusion tube is used to connect to the liquid injection head and is connected to the interior of the centrifuge tube through the liquid injection head. One end of the infusion tube is connected to the liquid injection head on one centrifuge container, and the other end of the infusion tube is connected to the liquid injection head on another centrifuge container.

[0034] However, the problem with this device is that, on the one hand, the syringe is not reinforced or protected, and in actual use, the syringe may break or the piston may fail under high-speed centrifugation conditions; on the other hand, the adjustment and extraction of this device cannot be precisely and stably controlled or maintained.

[0035] It is evident that, in existing technologies, PRP extraction either involves multiple transfers and secondary centrifugation, or it involves injecting PRP and PPP together. Multiple transfers increase the risk of infection, while injecting PRP and PPP together dilutes the PRP, potentially limiting its therapeutic effect. Summary of the Invention

[0036] The purpose of this invention is to provide a method for centrifuging platelet-rich plasma to solve the technical problems in the prior art.

[0037] To achieve the above objectives, the specific technical solution of the present invention is as follows: A platelet-rich plasma centrifuge device, characterized in that it includes a centrifuge support body, a first positioning part and a second positioning part are movably provided on the centrifuge support body, and a fixing part is provided on the centrifuge support body; The fixing part fixes the needle tip of the blood collection needle, the second positioning part fixes the needle body of the blood collection needle, and the first positioning part fixes the piston of the blood collection needle.

[0038] Furthermore, the centrifuge support body is provided with a slide rail, and the first positioning part and the second positioning part are disposed on the slide rail; A first fixing head is installed on the slide rail, and the fixing part is a bayonet set on the centrifugal support body. A second fixing head is installed at the bayonet.

[0039] Furthermore, the first positioning part is provided with a first groove that mates with the piston tail of the blood collection needle, and the second positioning part is provided with a second groove that mates with the syringe tail of the blood collection needle.

[0040] Furthermore, both the first and second positioning parts are provided with a three-way pipe, which is mounted on the slide rail and connected to a locking mechanism.

[0041] Furthermore, the first positioning part is provided with an extension rod, and the three-way tube on the first positioning part is disposed on the extension rod.

[0042] Furthermore, the first slot is a series of parallel, multi-layered grooves, with the size decreasing at each level.

[0043] Furthermore, the second slot is a multi-tiered, stepped open slot.

[0044] Furthermore, a storage box is provided below the centrifuge support body. The storage box is frame-shaped and installed at the bottom of the centrifuge support body. The bottom of the storage box is provided with a lid.

[0045] Furthermore, the storage box has a strip-shaped opening at one end and an opening at the other end; the lid has an L-shaped locking strip at one end that matches the strip-shaped opening, an opening at the other end, and a disassembly hole in the middle.

[0046] A method for centrifuging platelet-rich plasma using the platelet-rich plasma centrifuge apparatus as described in claims 1-9, characterized by comprising the following steps: Step 1: Attach a disposable blood collection needle to the blood collection needle, use the needle of the disposable blood collection needle to perform the blood collection operation, and after the blood collection is completed, insert the needle of the disposable blood collection needle into the blood collection bag. Step 2: Fix the blood collection needle and disposable blood collection needle tube to the centrifuge support, place the blood collection bag in the storage box, and close the box lid; Step 3: Place the entire centrifuge frame into the centrifuge for the first centrifugation and stratification. From the tail of the blood collection needle to the tip, the layers are: platelet-rich plasma (PPP), platelet-rich plasma (PRP), and red blood cells. Step 4: Release the locking mechanism, advance the first positioning part to drive the piston to discharge red blood cells through the disposable blood collection needle into the blood collection bag; Step 5: Place the centrifuge stand into the centrifuge with the needle tip facing the opposite direction to the first centrifugation for a second centrifugation to separate the layers. From the tail of the needle to the tip, the layers are: platelet-rich plasma (PRP) and platelet-rich plasma (PPP). Step 6: Release the locking mechanism again, and push the first positioning part to drive the piston to discharge platelet-rich plasma (PPP) through the disposable blood collection needle into the blood collection bag; Step 7: Finally, remove the blood collection needle from the centrifuge stent and inject the platelet-rich PRP into the patient.

[0047] The technical solution of the present invention has the following advantages: 1. Using a standard blood collection needle, centrifugation can be performed directly after blood collection. The entire process does not require the extraction and transfer of platelet-rich plasma, thus eliminating the risk of infection. 2. Centrifugation can be performed directly using a blood collection needle, resulting in low consumable costs and eliminating the need for additional sterilization after use; 3. The blood collection needle is fixed by the first and second positioning parts of this device, and the red blood cells inside are removed by the positioning parts after centrifugation, which enables more accurate separation. 4. The extracted PRP concentration is high, reducing the need for mixed injection of PRP and PPP, and avoiding the problem of swelling caused by excessive injection volume. Attached Figure Description

[0048] Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 This is a schematic diagram of the structure of the present invention after the blood collection needle is installed; Figure 3 This is an exploded structural diagram of the present invention, which includes a blood collection needle; Figure 4 This is a top view of the present invention; Figure 5 This is a bottom view of the present invention. Detailed Implementation

[0049] To better understand the purpose, structure, and function of this invention, a platelet-rich plasma centrifugation method of this invention will be described in further detail below with reference to the accompanying drawings.

[0050] Example 1 like Figures 1-3 As shown, an improved centrifuge support of the present invention includes a centrifuge support body 1, a first positioning part 2 and a second positioning part 3 movably disposed on the centrifuge support body 1, and a fixing part disposed on the centrifuge support body 1. The centrifuge support body 1 has a rectangular frame structure. The fixing part is preferably disposed at the end of the centrifuge support body 1 to facilitate the needle tip of the blood collection needle 6 to pass through and then connect to the blood collection bag 8 through the disposable blood collection needle tube 7.

[0051] Specifically, the blood collection needle 6 uses a universal disposable medical syringe.

[0052] During use, the fixing part locks the needle tip of the blood collection needle 6, the second positioning part 3 fixes the needle body of the blood collection needle 6, and the first positioning part 2 fixes the piston 61 of the blood collection needle.

[0053] Specifically, the second positioning part 3 abuts against the wing plate 601 at the tail of the blood collection needle 6, clamping the blood collection needle 6 together with the fixing part to prevent shaking and ensure stability during centrifugation. The first positioning part 2 fixes the piston 61 of the blood collection needle, and the push plate 611 at the tail of the piston 61 is engaged in the first positioning part 2. The first positioning part 2, together with the centrifuge support body 1, fixes the needle body of the blood collection needle 6 to prevent damage to the blood collection needle 6 during centrifugation.

[0054] like Figures 1-3 As shown, the centrifuge support body 1 is provided with a pair of slide rails 101, and the first positioning part 2 and the second positioning part 3 are slidably disposed on the slide rails 101. The slide rails 101 are rod-shaped and pass through both sides of the first positioning part 2 and the second positioning part 3.

[0055] Of course, as a commonly used alternative structure, the slide rail 101 can also be groove-shaped or strip-shaped, and is fitted on both sides of the first positioning part 2 and the second positioning part 3.

[0056] A first fixing head 10 is installed on the slide rail 101. One side of the first fixing head 10 is slidably installed on one of the slide rails 101. The other side is connected to the second positioning part 3 through the locking mechanism 102. After the first fixing head 10 is connected, it covers the second positioning part 3, which can further restrict the position of the blood collection needle 6 and prevent the blood collection needle 6 from falling off the centrifuge support body 1.

[0057] Specifically, as shown in the figure, one side of the first fixing head 10 has a forked structure, with both ends of the fork located on both sides of the second positioning part 3, to avoid structural interference with the locking mechanism 102 that fixes the second positioning part 3. The ends of the forks are ring-shaped structures that are fitted onto the slide rail 101, enabling them to open and close, and are used to fix the blood collection needle 6 in the second positioning part 3.

[0058] like Figures 1-3 As shown, the first positioning part 2 is provided with a first slot 201, which is used to hold the wing plate 601 at the tail of the needle body of the blood collection needle 6. The second positioning part 3 is provided with a second slot 301 that engages with the push plate 611 at the tail of the piston 61 of the blood collection needle 6.

[0059] Specifically, structurally, the first slot 201 is a multi-layered U-shaped slot arranged side by side, with the size decreasing at each level, which can accommodate the push plate 611 of blood collection needles 6 of different sizes; the second slot 301 is a multi-stage stepped open slot, which can accommodate blood collection needles 6 of different sizes. The first slot 201 and the second slot 301, as well as the fixing part on the support body 1, together fix the blood collection needle 6.

[0060] Example 2 In this embodiment, both the first positioning part 2 and the second positioning part 3 are provided with a three-way pipe 203. The slide rail 101 passes laterally through the three-way pipe 203, and the opening at the top of the three-way pipe 203 is connected to the locking mechanism 102. The locking mechanism 102 is threadedly connected to the three-way pipe 203. After tightening the locking mechanism 102, the movement of the slide rail 101 in the three-way pipe 203 can be restricted by frictional force, thereby further controlling the position of the first positioning part 2 and the second positioning part 3.

[0061] The first fixed clamp 10 is also connected to the second positioning part 3 through the locking mechanism 102, and the other side is connected to one of the slide rails 101 through the locking mechanism 102.

[0062] Example 3 In this embodiment, the first positioning part 2 is provided with an extension rod 202, and a three-way tube 203 on the first positioning part 2 is disposed on the extension rod 202. The slide rail 101 passes through the body of the first positioning part 2 and then through the three-way tube 203 at the end of the extension rod 202. This makes the sliding of the first positioning part 2 on the slide rail 101 more stable, reduces the torque on the blood collection needle 6 during shaking and centrifugation, and facilitates more precise operation of the blood collection needle 6. It also improves structural stability and avoids twisting and damage to the main structure of the blood collection needle 6 during centrifugation.

[0063] Example 4 In this embodiment, as Figure 3 and Figure 5 As shown, a storage box 4 is located below the centrifuge support 1. The storage box 4 is frame-shaped and is installed at the bottom of the centrifuge support 1 with screws. A lid 5 is located at the bottom of the storage box 4. A blood collection bag 8 is placed inside the storage box 4, and the blood collection bag 8 is connected to a blood collection needle 6 via a disposable blood collection needle tube 7. By using universal medical equipment, universality is ensured, eliminating the need for specialized equipment to remove centrifuged red blood cells and anemic platelet-rich plasma (PPP), thus reducing the cost of use for patients.

[0064] Meanwhile, the centrifugation process eliminates the need for transferring and reconnecting equipment, reducing the risk of infection.

[0065] Specifically, the storage box body 4 has a strip-shaped opening 401 at one end and an opening 402 at the other end; the box cover 5 has an L-shaped locking strip 501 at one end that cooperates with the strip-shaped opening 401, an opening 402 at the other end, and a disassembly hole 502 in the middle for easy handling.

[0066] When in use, insert the L-shaped clip 501 into the strip opening 401 and secure it with a screw passing through the opening 402.

[0067] Example 5 like Figure 1 As shown, the fixing part is a U-shaped bayonet 103 set on the centrifuge support body 1, and a second fixing head 9 is installed at the bayonet 103. One end of the second fixing head 9 is connected to the centrifuge support body 1 through a rotating shaft, and the other end is threadedly connected to the centrifuge support body 1 through a locking mechanism 102.

[0068] The centrifuge support body 1 is provided with a wire hole 105, and there is an opening on one side of the wire hole 105, which is used to insert and fix the disposable blood collection needle tube 7 during use.

[0069] At the same time, such as Figure 3 As shown, the wire holes 105 are distributed on both sides of the storage box 4. The advantage of this arrangement is that it is convenient for both left-handed and right-handed medical staff to operate.

[0070] Among them, such as Figures 1-4 As shown, an arc-shaped plate 204 is connected between the extension rods 202 of the first positioning part 2, which can make the structure between the extension rods 202 more stable on the one hand, and prevent the extension rods 202 from bending on the other hand.

[0071] Example 6 In this embodiment, as Figure 1 and Figure 3 As shown, the centrifuge support body 1 is composed of two symmetrical parts. Several reinforcing ribs 104 are provided on the side of the centrifuge support body 1. Transverse reinforcing ribs are connected between the reinforcing ribs 104. While reducing the weight, the device can withstand the huge centrifugal force when the centrifuge is working.

[0072] This structure reduces the weight of the device, preventing excessive inertia, and also avoids placing excessive demands on the centrifuge's power due to the device's weight.

[0073] Example 7 A method for centrifuging platelet-rich plasma includes the following steps: Step 1: Install a disposable blood collection needle tube 7 on the blood collection needle 6, use the needle of the disposable blood collection needle tube 7 to perform blood collection, and after the blood collection is completed, insert the needle of the disposable blood collection needle tube 7 into the blood collection bag 8. Step 2: Fix the blood collection needle 6 and disposable blood collection tube 7 onto the centrifuge support 1, place the blood collection bag 8 in the storage box 4, and close the box lid 5; Step 3: Place the entire centrifuge support 1 into the centrifuge for the first centrifugation and stratification. From the tail of the blood collection needle 6 to the tip, the layers are: platelet-rich plasma (PPP), platelet-rich layer (PRP), and red blood cells. Step 4: Release the locking mechanism 102, and push the first positioning part 2 to drive the piston 61 to discharge red blood cells through the disposable blood collection needle tube 7 into the blood collection bag 8; Step 5: Place the blood collection needle 6 with the needle tip facing the opposite direction to the first centrifugation into the centrifuge for a second centrifugation to separate the layers. From the tail of the blood collection needle to the tip, the layers are: platelet-rich plasma (PRP) and platelet-rich plasma (PPP). Step 6: Release the locking mechanism 102 again, and push the first positioning part 2 to drive the piston 61 to discharge platelet-rich plasma (PPP) through the disposable blood collection needle tube 7 into the blood collection bag 8; Step 7: Finally, remove the blood collection needle 6 from the centrifuge stent 1 and inject the platelet-rich layer PRP into the patient.

[0074] It can be seen that throughout the process, no additional extraction or transfer of containers was required for the blood drawn. The consumables used were common medical supplies such as blood collection needles, disposable blood collection tubing, and blood bags, resulting in low operating costs, high maturity, and strong reliability. During the promotion process, medical users showed higher acceptance, requiring no additional training or learning, offering significant advantages in terms of both time and operating costs.

[0075] Specifically, in steps 2 and 5, the disposable blood collection needle 7 needs to be clamped to prevent plasma from flowing between the blood collection bag 8 and the disposable blood collection needle 7. It is understood that this invention has been described through some embodiments, and those skilled in the art will recognize that various changes or equivalent substitutions can be made to these features and embodiments without departing from the spirit and scope of the invention. Furthermore, under the teachings of this invention, these features and embodiments can be modified to adapt to specific situations and materials without departing from the spirit and scope of the invention. Therefore, this invention is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are within the protection scope of this invention.

Claims

1. A platelet rich plasma centrifugation device, characterized by, Including centrifugal support body (1), first positioning part (2) and second positioning part (3) are movably arranged on the centrifugal support body (1), and the centrifugal support body (1) is provided with a fixed part; The fixed part fixes the needle of the blood taking needle, the second positioning part (3) fixes the needle body of the blood taking needle, and the first positioning part (2) fixes the piston of the blood taking needle.

2. The platelet rich plasma centrifuge device of claim 1, wherein, The centrifugal support body (1) is provided with a sliding rail (101), and the first positioning part (2) and the second positioning part (3) are arranged on the sliding rail (101); The first fixed jaw (10) is installed on the sliding rail (101), the fixed part is a bayonet (103) arranged on the centrifugal support body (1), and the second fixed jaw (9) is installed at the bayonet (103).

3. The platelet rich plasma centrifuge device of claim 2, wherein, The first positioning part (2) is provided with a first clamping groove (201) matched with the tail part of the piston of the blood taking needle, and the second positioning part (3) is provided with a second clamping groove (301) matched with the tail part of the needle barrel of the blood taking needle.

4. The platelet rich plasma centrifuge device of claim 3, wherein, The first positioning part (2) and the second positioning part (3) are both provided with a three-way pipe (203), the three-way pipe (203) is arranged on the sliding rail (101), and the three-way pipe (203) is connected with a locking mechanism (102).

5. The platelet rich plasma centrifuge device of claim 4, wherein, The first positioning part (2) is provided with an extension rod (202), and the three-way pipe (203) on the first positioning part (2) is arranged on the extension rod (202).

6. The platelet rich plasma centrifuge device of claim 5, wherein, The first clamping groove (201) is a plurality of recesses arranged side by side, and the size gradually decreases.

7. The platelet rich plasma centrifuge device of claim 6, wherein, The second clamping groove (301) is a multi-stage recessed slot.

8. The platelet rich plasma centrifuge device of claim 7, wherein, The centrifugal support body (1) is provided below with a storage box body (4), the storage box body (4) is frame-shaped, is installed at the bottom of the centrifugal support body (1), and the bottom of the storage box body (4) is provided with a box cover (5).

9. The platelet rich plasma centrifuge device of claim 8, wherein, One end of the storage box body (4) is provided with a strip-shaped opening (401), and one end is provided with an opening (402); one end of the box cover (5) is provided with an L-shaped clamping strip (501) matched with the strip-shaped opening (401), one end is also provided with an opening (402), and a middle part is provided with a dismounting hole (502).

10. A method of preparing platelet-rich plasma using the platelet-rich plasma centrifuge device according to any one of claims 1 to 9, wherein The steps include: Step 1: install a disposable blood taking needle barrel (7) on the blood taking needle (6), perform blood taking operation on the needle of the disposable blood taking needle barrel (7), and insert the needle of the disposable blood taking needle barrel (7) into the blood taking bag (8) after blood taking is completed; Step 2: fix the blood taking needle (6) and the disposable blood taking needle barrel (7) on the centrifugal support body (1), place the blood taking bag (8) in the storage box body (4), and cover the box cover (5); Step 3: put the centrifugal support body (1) into the centrifuge as a whole, perform first centrifugal separation, and sequentially from the tail part of the blood taking needle (6) to the needle head part: platelet rich plasma PPP, platelet rich layer PRP, and red blood cells; Step 4: loosen the locking mechanism (102), push the first positioning part (2) to drive the push piston (61) to discharge the red blood cells through the disposable blood taking needle barrel (7) to the blood taking bag (8). Step 5: Place the blood collection needle (6) into the centrifuge support body (1) in the opposite direction of the first centrifugation, and perform secondary centrifugation to separate the layers. From the tail of the blood collection needle to the needle head, the layers are: platelet-rich plasma PRP, platelet-rich plasma PPP; Step 6: Loosen the locking mechanism (102) again, advance the first positioning part (2) to drive the push piston (61) to expel the platelet-rich plasma PPP through the disposable blood collection needle tube (7) to the blood collection bag (8); Step 7: Finally, remove the blood collection needle (6) from the centrifuge support body (1) and inject the platelet-rich plasma PRP into the patient's body.

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