Anti-hair loss composition based on extraction technology, preparation method and tea drink

Abstract

The invention provides an anti-hair loss composition based on an extraction technology, a preparation method and a tea drink. Relates to the technical field of anti-hair-loss products and hair growth. The composition is prepared from the following raw materials: radix polygoni multiflori, mulberries, rhizoma polygonati, black beans, black rice, lycium ruthenicum, rosa roxburghii tratt fruits, radix codonopsis, raspberries, radix rehmanniae praeparata and trace additives. The ratio of the polygonum multiflorum to the mulberry to the rhizoma polygonati to the black beans to the black rice to the lycium ruthenicum to the roxburgh rose to the codonopsis pilosula to the raspberry to the prepared rehmannia root to the trace additive is 7: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 4. Experiments prove that the composition formed according to the formula can improve the resistance of hair follicles to dihydrotestosterone, increase the self-repairing capacity of the hair follicles and enable the atrophic or dormant hair follicles to enter the growth period again, so that hair growth is promoted, and the composition further has the effect of reducing alopecia.

Description

Technical Field

[0001] This disclosure relates to the fields of anti-hair loss products and hair growth technology, specifically to anti-hair loss compositions based on extraction technology, preparation methods, and tea beverage technology. Background Technology

[0002] Survey data shows that as many as 160 million people in my country suffer from hair loss. Among men, one in four has hair loss problems. Moreover, due to external factors such as increased environmental pollution, irregular diet, and high work pressure, the age of people experiencing hair loss is becoming increasingly younger. As the public's awareness of health and beauty grows stronger, hair loss is attracting more and more attention.

[0003] Hair loss can be classified into normal hair loss and pathological hair loss according to its cause. Normal hair loss refers to the shedding of hairs in the telogen or catagen phase. A normal person loses 70-100 hairs per day, which is caused by the metabolism of hair follicle cells in the scalp and is part of the body's normal metabolism. Pathological hair loss, on the other hand, refers to the loss of hair due to insufficient nutrition caused by the degeneration or telogen phase of normal hair follicle cells. Pathological hair loss often leads to baldness, alopecia areata, and other similar conditions.

[0004] In response to this phenomenon, two treatment approaches have emerged in the market: traditional Chinese medicine and Western medicine. Traditional Chinese medicine products are based on the theories of traditional Chinese medicine and use compound herbal extracts. Depending on the ingredients in the formula, they can produce effects such as nourishing or oil control to prevent hair loss. However, based on consumer feedback, most of these products are not very effective. Western medicine, on the other hand, focuses on stimulating hair follicles with trace elements to promote hair growth.

[0005] However, in existing technologies, the effects of traditional Chinese medicine are not obvious. In order to increase transdermal absorption, Western medicine either increases the dosage or uses large amounts of penetration enhancers such as ethanol. This not only increases costs but also increases the burden on the scalp, which is not worthwhile. Therefore, there is an urgent need for a safe and effective product to treat hair loss to solve the problems in existing technologies. Summary of the Invention

[0006] This disclosure provides a hair loss prevention composition, preparation method, and tea based on extraction technology, which can effectively slow down hair loss and promote hair growth, better meeting users' needs for hair loss prevention and hair growth.

[0007] According to a first aspect of this disclosure, an anti-hair loss composition based on extraction technology is provided, the raw materials of the composition comprising:

[0008] Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives;

[0009] The proportions of the following ingredients are as follows: Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives are 7:1:1:1:1:1:1:1:1:1:1:4.

[0010] Furthermore, the effective substances of the Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives are obtained through extraction.

[0011] Optionally, the trace additives include at least: sea cucumber peptides, proteins, walnut peptides, sunflower seed oil, riboflavin, niacin, pantothenic acid, and trace elements such as selenium and zinc.

[0012] Optionally, the ratio of the sea cucumber peptide, the protein, the walnut peptide, the sunflower seed oil, the riboflavin, the niacin, the pantothenic acid, and the selenium and zinc trace elements is 8:5:2:1:1:1:1:1.

[0013] Optionally, the composition further includes trace metal elements, wherein the trace metal elements include at least one of the following:

[0014] Optionally, the extraction is any one of ethanol extraction, ultrasonic extraction, microwave-assisted extraction, and spray drying extraction.

[0015] Optionally, the polysaccharides, anthraquinone compounds, cellulose, minerals, lecithin, and ginsenosides in the Polygonum multiflorum can be obtained through the extraction.

[0016] Optionally, the anthocyanin content in the black goji berries obtained by the extraction is approximately 8 mg / g to 30 mg / g.

[0017] According to a second aspect of this disclosure, a method for preparing an anti-hair loss composition based on extraction technology is provided, for preparing the composition according to any one of the first aspects, the method comprising:

[0018] Take Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black wolfberry, prickly pear, Codonopsis pilosula, raspberry, and Rehmannia glutinosa according to the preset ratio, crush them, and use ethanol extraction method. The extraction temperature is 40±5℃, the extraction pressure is atmospheric pressure, the extraction method is ethanol reflux extraction, and the reflux number is 4-6 times to obtain product A1.

[0019] The undissolved portions of the above-mentioned Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black wolfberry, prickly pear, Codonopsis pilosula, raspberry, and Rehmannia glutinosa were extracted using ultrasonic extraction to obtain product A2.

[0020] Mix A1 and A2, and enzymatically hydrolyze them with dextranase for 4-6 hours. Then, enzymatically hydrolyze them with hydrolytic protease for 4-6 hours. After sterilization, product A3 is obtained. Add the trace additives in proportion to obtain product A4.

[0021] According to a third aspect of this disclosure, an anti-hair loss tea beverage based on extraction technology is provided, characterized in that the tea beverage comprises the composition described in any one of the first aspects and instant green tea, wherein the mass ratio of the composition to the instant green tea is 5:1, and the anti-hair loss tea beverage is prepared after thorough mixing.

[0022] This disclosure discloses an anti-hair loss composition based on extraction technology. The raw materials of the composition include: Polygonum multiflorum, mulberry, Polygonatum sibiricum, black beans, black rice, black goji berries, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives. The ratio of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black beans, black rice, black goji berries, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives is 7:1:1:1:1:1:1:1:1:1:1:4. Experiments have shown that the composition formed according to the above formula can improve the resistance of hair follicles to dihydrotestosterone, increase the self-repair ability of hair follicles, and allow atrophied or dormant hair follicles to re-enter the growth phase, thereby promoting hair growth. Furthermore, the composition of this application also has the effect of reducing hair loss.

[0023] It should be understood that the description in this section is not intended to identify key or essential features of the embodiments of this disclosure, nor is it intended to limit the scope of this disclosure. Other features of this disclosure will become readily apparent from the following description. Attached Figure Description

[0024] The accompanying drawings are provided to better understand this solution and do not constitute a limitation of this disclosure. Wherein:

[0025] Figure 1 A columnar comparison chart of an anti-hair loss composition based on extraction technology provided in an embodiment of this disclosure;

[0026] Figure 2 A columnar comparison chart of another anti-hair loss composition based on extraction technology provided in this disclosure embodiment;

[0027] Figure 3 A line graph comparing an anti-hair loss composition based on extraction technology provided in this embodiment of the present disclosure;

[0028] Figure 4 A line graph comparing another hair loss prevention composition based on extraction technology provided in this embodiment of the present disclosure. Detailed Implementation

[0029] The exemplary embodiments of this disclosure are described below with reference to the accompanying drawings, including various details of the embodiments to aid understanding, and should be considered merely exemplary. Therefore, those skilled in the art will recognize that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of this disclosure. Similarly, for clarity and brevity, descriptions of well-known functions and structures are omitted in the following description.

[0030] It should be understood that in the embodiments of this disclosure, the character " / " generally indicates that the preceding and following objects are in an "or" relationship. The terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated.

[0031] This application provides a hair loss prevention composition based on extraction technology. The raw materials of the composition include: Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives. The proportions of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives are 7:1:1:1:1:1:1:1:1:1:1:4. The effective substances are obtained by extraction of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives.

[0032] In practical applications, Polygonum multiflorum contains a variety of active ingredients, such as polysaccharides, anthraquinone compounds, cellulose, minerals, lecithin, ginsenosides, and other substances.

[0033] Polygonum multiflorum contains a variety of polysaccharides, such as pentasaccharides, hexasaccharides, and heptasaccharides. These polysaccharides have strong antioxidant and antitumor activities, which help promote scalp health and provide a good environment for hair growth.

[0034] Anthraquinone compounds: mainly including rhein, emodin, and chrysophanol, these components have a variety of biological activities and may have an indirect promoting effect on hair growth.

[0035] Cellulose: Polygonum multiflorum is rich in cellulose, which helps maintain gastrointestinal health, promotes the absorption and utilization of nutrients, and thus provides necessary nutritional support for hair growth.

[0036] Minerals: Polygonum multiflorum contains a variety of minerals such as calcium, iron, and zinc. These minerals play an important role in hair growth and strength. For example, iron helps prevent anemia, promotes hemoglobin synthesis, thereby improving scalp blood circulation and promoting hair growth.

[0037] Lecithin: The lecithin contained in Polygonum multiflorum also has certain benefits for scalp health, as it helps maintain the normal metabolism and renewal of scalp cells.

[0038] Ginsenosides: Ginsenosides contained in Polygonum multiflorum have multiple effects, such as improving the body's immunity and cardiovascular health, which may indirectly promote hair growth.

[0039] After simple processing, Polygonum multiflorum can have certain effects in preventing hair loss and promoting hair growth.

[0040] Black goji berries have a high anthocyanin content, which gives them a significant antioxidant effect and effectively combats free radical damage. The following is a detailed explanation of this phenomenon.

[0041] Anthocyanins are a type of flavonoid compound that, based on a flavonoid nucleus, gives the fruit its red color. Black goji berries are rich in anthocyanins, with a dry weight content ranging from approximately 8.21 mg to 31.46 mg / g, a figure significantly higher than many other fruits and vegetables such as blueberries, raspberries, and purple cabbage. Due to their unique functionalities, anthocyanins are widely studied and applied.

[0042] Anthocyanins have antioxidant properties that can scavenge free radicals: the molecular structure of anthocyanins contains multiple phenolic hydroxyl groups, which act as hydroxyl donors and can react with free radicals, thereby scavenging free radicals in the body. Free radicals are harmful substances produced during metabolism; they attack cells and tissues, leading to damage and aging. The antioxidant properties of anthocyanins help maintain the balance of free radicals in the body and protect cells from free radical damage.

[0043] Furthermore, anthocyanins activate the antioxidant enzyme system: Anthocyanins can enhance antioxidant effects by activating the body's antioxidant enzyme system. These antioxidant enzymes include superoxide dismutase, catalase, and glutathione peroxidase, which play important roles in scavenging free radicals and protecting cells from oxidative stress. The activating effect of anthocyanins allows these antioxidant enzymes to function more effectively, thereby further enhancing the body's antioxidant capacity.

[0044] Inhibition of lipid peroxidation: Anthocyanins not only scavenge free radicals but also inhibit lipid peroxidation. Lipid peroxidation is a process in which free radicals attack lipid components in biological membranes, leading to lipid denaturation, aging, and damage. Anthocyanins effectively inhibit lipid peroxidation by providing protons and cleaving the oxidation process in fatty acid chain reactions, thereby protecting the structure and function of biological membranes.

[0045] In addition, mulberry, polygonatum, black beans, black rice, black goji berries, prickly pear, codonopsis, raspberry, and prepared rehmannia root all have certain effects in preventing hair loss in practical applications.

[0046] The specific proportions of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, and Rehmannia glutinosa were obtained through experiments and will be briefly explained here.

[0047] Experiments have verified the hair growth effect of adding different doses of raw materials to the original formula of the above composition, with an experimental period of 7 weeks.

[0048] The experiment was a hair regrowth test, and the details are as follows:

[0049] Sixty volunteers, aged 30-40 years, half male and half female, were selected for the experiment. All volunteers had no skin diseases but experienced hair loss. Human trials of the compositions described in the embodiments of this invention were conducted according to the basic principles and methods for human skin testing as outlined in the 2002 edition of the "Cosmetic Hygiene Standards" issued by the Ministry of Health of the People's Republic of China.

[0050] The specific methods are as follows: Control group 1 is an aqueous solution with the same amount of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives. Experimental group 1 is an aqueous solution with the same amount of mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives, with Polygonum multiflorum being 4 times the amount of other raw materials and black goji berry being 2 times the amount of other raw materials. Experimental group 2 is an aqueous solution with the same amount of mulberry, Polygonatum sibiricum, black bean, black rice, black goji berry, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives, with Polygonum multiflorum being 8 times the amount of other raw materials and black goji berry being 4 times the amount of other raw materials.

[0051] The experiment divided 60 volunteers into three groups of 20 each. The first group of volunteers drank control group 1 every day, the second group of volunteers drank experimental group 1 every day, and the third group of volunteers drank experimental group 2 every day. The volunteers were not informed of the items they were drinking beforehand.

[0052] The experiment lasted for 7 weeks. The table below shows the measurement phase after the experiment ended. Please refer to Table 1 for the experimental results.

[0053] Table 1

[0054]

[0055]

[0056] like Figure 1 As shown, Figure 1 A bar chart comparing an anti-hair loss composition based on extraction technology provided in this embodiment of the present disclosure. Figure 1 The results showed that, compared with control group 1, experimental group 1 provided by this application had a significant hair regrowth effect, with an average daily hair regrowth of approximately 65 strands, which is close to the level of a normal person. Therefore, it is shown that the composition provided by this application has a relatively significant hair regrowth effect.

[0057] Compared with control group 1, experimental group 2 provided by this application has a stronger hair growth effect, with about 95 hairs growing per day. According to data published by the World Health Organization, the normal number of hairs growing per day is 50-150, which is within the normal metabolism. The effect of experimental group 2 provided by this application is higher than the normal level of ordinary people. Therefore, the composition corresponding to experimental group 2 provided by this application has a more obvious hair growth effect.

[0058] Optionally, trace additives may be added to the composition to enhance its ability to prevent hair loss and promote hair growth.

[0059] Specifically, the trace additives include at least: sea cucumber peptides, proteins, walnut peptides, sunflower seed oil, riboflavin, niacin, pantothenic acid, and trace elements such as selenium and zinc.

[0060] Optionally, the ratio of the sea cucumber peptide, the protein, the walnut peptide, the sunflower seed oil, the riboflavin, the niacin, the pantothenic acid, and the selenium and zinc trace elements is 8:5:2:1:1:1:1:1.

[0061] Sea cucumber peptides are made using molecular biotechnology, which degrades large protein molecules into small active peptides. These small peptides are more easily absorbed by the human body and can quickly provide the scalp and hair follicles with the necessary nutrients, indirectly improving the body's hair growth ability.

[0062] Furthermore, sea cucumber peptides contain a large amount of arginine and protein, which have antioxidant and anti-inflammatory effects: the antioxidant components in sea cucumber peptides can eliminate free radicals in the body, reduce oxidative stress on the scalp, thereby protecting scalp health and providing a good environment for hair growth.

[0063] Promotes cell regeneration: Certain components in sea cucumber peptides, such as salmon protamine, can repair scalp cell DNA, promote scalp cell regeneration, help improve scalp condition, and promote hair growth.

[0064] Optionally, walnut peptides are rich in essential nutrients for brain cell metabolism, such as glutamic acid, which nourish brain cells and enhance brain function. Simultaneously, walnut peptides participate in brain tissue metabolism, helping to improve scalp blood circulation, providing more nutrients and oxygen to hair follicles, thereby promoting healthy hair growth.

[0065] Walnut peptides also have antioxidant properties, reducing free radical damage. Walnut peptides contain antioxidants such as vitamin E, which can eliminate free radicals in the body and reduce their damage to the scalp and hair follicles. Free radicals are a major factor leading to hair aging and loss; therefore, the antioxidant effect of walnut peptides is significant for protecting hair health and promoting hair growth.

[0066] Walnut peptides also have the effect of regulating hormone levels and promoting hair growth. Certain components of walnut peptides may help regulate hormone levels in the body, such as androgens. Androgens are one of the important factors affecting hair growth, and appropriate amounts of androgens can promote hair growth. Therefore, walnut peptides may help promote hair growth and development by regulating hormone levels.

[0067] Walnut peptides are also rich in vitamins and minerals, such as B vitamins, calcium, and iron. These components play an important role in improving the scalp environment and reducing hair loss. For example, B vitamins help promote normal scalp sebum secretion, keeping the scalp moisturized and elastic; while minerals such as calcium and iron help enhance hair's resilience and elasticity, reducing breakage and hair loss.

[0068] The additives are formed by combining them in a preset ratio.

[0069] The specific ratio was obtained through experiments, and will be briefly explained here.

[0070] Experiments have verified the hair growth effects of adding different doses of sea cucumber peptides, protein, walnut peptides, sunflower seed oil, riboflavin, niacin, pantothenic acid, and selenium-zinc trace elements to the original formula of the above-mentioned composition. The experimental period was 7 weeks.

[0071] The experiment was a hair regrowth test, and the details are as follows:

[0072] Sixty volunteers, aged 30-40 years, half male and half female, were selected for the experiment. All volunteers had no skin diseases but experienced hair loss. Human trials of the compositions described in the embodiments of this invention were conducted according to the basic principles and methods for human skin testing as outlined in the 2002 edition of the "Cosmetic Hygiene Standards" issued by the Ministry of Health of the People's Republic of China.

[0073] The specific method is as follows: Control group 1 is an aqueous solution with the same amount of sea cucumber peptide, protein, walnut peptide, sunflower seed oil, riboflavin, niacin, pantothenic acid, and selenium and zinc trace elements. Experimental group 1 is an aqueous solution with the same amount of sea cucumber peptide, protein, walnut peptide, sunflower seed oil, riboflavin, niacin, pantothenic acid, and selenium and zinc trace elements. The amount of sea cucumber peptide is 8 times that of other raw materials, the amount of protein is 4 times that of other raw materials, and the amount of walnut peptide is 2 times that of other raw materials.

[0074] The experiment divided 60 volunteers into three groups of 30 each. The first group of volunteers drank the control group 1 every day, and the second group of volunteers drank the experimental group 1 every day.

[0075] The experiment lasted for 7 weeks. The table below shows the measurement phase after the experiment ended. Please refer to Table 2 for the experimental results.

[0076] Table 2

[0077]

[0078] like Figure 2 As shown, Figure 2 A columnar comparison chart of another anti-hair loss composition based on extraction technology provided in this disclosure embodiment; Figure 2 The results showed that, compared with control group 1, the average daily hair growth was about 95 hairs. According to data released by the World Health Organization, the normal daily hair growth is 50-150 hairs, which is within the normal metabolic range. The effect of experimental group 2 in this application is higher than the normal level of ordinary people. Therefore, the composition corresponding to experimental group 2 provided in this application has a more obvious hair growth effect.

[0079] Compared with control group 1, experimental group 1 provided by this application has a stronger hair growth effect, with about 120 hairs growing per day. The effect of experimental group 1 of this application is higher than the normal level of ordinary people. Therefore, the composition corresponding to experimental group 2 provided by this application has a more obvious hair growth effect.

[0080] Optionally, the composition further includes trace metal elements, which include at least one of zinc, iron, and copper.

[0081] Specifically, experiments have shown that zinc, iron, and copper have significant effects on preventing hair loss and promoting hair growth.

[0082] Zinc plays a crucial role in hair growth. It is a component of many enzymes and participates in cell division and protein synthesis, all of which are essential for hair growth. Zinc deficiency can lead to brittle, easily broken hair and may affect the normal hair growth cycle.

[0083] Zinc is one of the essential trace elements for the human body, playing a vital role in the scalp and hair follicles. Zinc promotes hair growth because it participates in the activity of many enzymes related to hair growth, which are crucial for the hair growth cycle and speed.

[0084] Zinc can also enhance the DNA synthesis and division capabilities of scalp cells, thereby accelerating scalp cell renewal and repair, and providing a better environment for hair growth.

[0085] Zinc plays a crucial role in scalp health. It regulates sebum secretion, preventing excessively oily hair and dandruff. This is essential for maintaining a clean and healthy scalp, as excessive oil and dandruff can negatively impact the hair growth environment and even lead to hair loss.

[0086] Zinc also has certain antibacterial and anti-inflammatory effects, which can reduce scalp inflammation and infection and protect scalp health.

[0087] Zinc deficiency can cause hair to become brittle, dry, and prone to falling out. Sufficient zinc intake can effectively improve hair quality, making it stronger and shinier.

[0088] Zinc can also promote melanin synthesis in hair, helping to maintain the natural color of hair and prevent it from turning white or yellow.

[0089] Iron is a component of hemoglobin, which is responsible for transporting oxygen to all parts of the body, including the scalp and hair follicles. Iron deficiency can lead to anemia, which in turn affects blood supply to the scalp and nutrition to the hair follicles, thus hindering normal hair growth.

[0090] Hair stability: Iron also helps maintain hair stability. A deficiency in iron can lead to dry, frizzy, and brittle hair. This is because iron participates in many enzymatic reactions related to hair health, such as promoting keratin synthesis.

[0091] Reduce factors that contribute to hair loss: Iron deficiency can also lead to poor blood circulation in the scalp, which in turn affects normal hair growth. Supplementing with iron can improve scalp blood circulation and reduce hair loss caused by insufficient blood supply.

[0092] For hair loss caused by anemia, iron supplementation is particularly important. Anemic patients often have low levels of hemoglobin in their blood; iron supplementation can improve anemia and thus alleviate hair loss symptoms. This is especially true for women, who are more prone to anemia-related hair loss due to iron loss caused by menstruation and childbirth.

[0093] Although copper is present in small amounts in hair, it plays an important role in hair health. Copper is involved in hair pigment formation and strength maintenance; a lack of copper can lead to lighter hair color and more brittle texture.

[0094] Copper is an essential trace element for the human body and plays a role in promoting melanin synthesis. Melanin is an important component of hair color. If the body is deficient in copper, it may lead to a reduction in melanin, resulting in graying hair. Although this is directly related to hair color rather than hair loss itself, maintaining the natural color of hair is also part of maintaining hair health, and indirectly helps reduce the psychological stress or damage to hair caused by improper treatments (such as frequent hair dyeing) that may result from graying hair.

[0095] Copper plays a vital role in hair growth. It participates in the formation of hair keratin fibers and stimulates the proliferation of hair monolayer keratinocytes and fibroblasts. Copper also participates in activating enzyme systems for tissue formation and repair, which are essential for healthy hair growth and repair. Copper deficiency can affect the hair keratinization process, hindering hair growth, causing hair to become lighter in color, dry, frizzy, and prone to falling out.

[0096] Copper and iron coexist in the same food, and their combined effect helps strengthen hair. Copper also helps promote iron absorption, and iron is an essential element for ensuring the oxygen content of the blood delivered to the hair. Iron deficiency can lead to oxygen deprivation in hair follicles, causing them to shrink, resulting in dry and falling hair. Therefore, by promoting iron absorption, copper indirectly helps improve blood supply to the hair, thus maintaining healthy hair growth.

[0097] Because of its role in promoting melanin synthesis and maintaining healthy hair growth, copper also helps prevent premature graying and hair loss. Consuming copper-rich foods or supplementing with copper can help maintain the natural color and strength of hair, reducing the distress caused by hair problems.

[0098] Experiments have verified the anti-hair loss effects of adding different doses of zinc, iron, and copper to the original formula of the above-mentioned composition. It should be noted that zinc, iron, and copper are all metallic elements. Therefore, for safety reasons, the experiment was conducted with one part zinc containing 5 mg, one part iron containing 200 mg, and one part copper containing 1 mg. The experimental period was 7 weeks.

[0099] The experiment was a hair growth and hair loss prevention test, and the specific details are as follows:

[0100] Sixty volunteers, aged 30-40 years, half male and half female, were selected for the experiment. All volunteers had no skin diseases but experienced hair loss. Human trials of the compositions described in the embodiments of this invention were conducted according to the basic principles and methods for human skin testing as outlined in the 2002 edition of the "Cosmetic Hygiene Standards" issued by the Ministry of Health of the People's Republic of China.

[0101] The specific methods are as follows: control group 1 is a starch aqueous solution, experimental group 1 is 0.05 ml of the composition mixed into the solution as the test sample and added dropwise to the aqueous solution; experimental group 2 is 0.05 ml of the composition and a portion containing zinc, iron and copper added dropwise to the aqueous solution.

[0102] The experiment divided 60 volunteers into three groups of 20 each. The first group of volunteers drank control group 1 every day, the second group of volunteers drank experimental group 1 every day, and the third group of volunteers drank experimental group 2 every day. The volunteers were not informed of the items they were drinking beforehand.

[0103] The experiment lasted for 7 weeks, and the results are shown in Table 3.

[0104] Table 3

[0105]

[0106]

[0107] like Figure 3 As shown, Figure 3 A line graph comparing an anti-hair loss composition based on extraction technology provided in this embodiment of the present disclosure; Figure 3 The results showed that, compared with control group 1, experimental group 1 provided by this application had a significant anti-hair loss effect, with the daily hair loss amount reduced to 160-180 strands. Therefore, it is indicated that the composition provided by this application has a relatively significant anti-hair loss effect.

[0108] Compared with control group 1, experimental group 2 provided in this application has a stronger effect on preventing hair loss, with approximately 120 hairs lost per day. According to data released by the World Health Organization, the normal amount of hair loss per day is 70-100 hairs, which is within the normal metabolic process.

[0109] Optionally, the extraction is any one of ethanol extraction, ultrasonic extraction, microwave-assisted extraction, and spray drying extraction.

[0110] Ethanol extraction: This method utilizes the solubility of ethanol as a solvent to separate and purify substances. It is widely used in chemical experiments, chemical purification, pharmaceutical manufacturing, and the preparation of traditional Chinese medicine preparations.

[0111] Its features include low cost, safety, no side effects, and recyclability.

[0112] Ultrasonic extraction: This method uses an ultrasonic extractor, leveraging the multi-stage effect generated by ultrasonic radiation pressure to accelerate the extraction of target components into the solvent. Its advantages include high extraction efficiency, short extraction time, and ease of operation. It is suitable for various solvents and target components, and is particularly suitable for the extraction of heat-sensitive substances.

[0113] Microwave-assisted extraction technology: This technology uses microwave heating to rapidly raise the internal temperature of cells, causing cell walls to rupture and thus accelerating the release of target components.

[0114] Its key features include high extraction efficiency and reduced extraction time. It is suitable for the extraction of various Chinese medicinal herbs and natural products.

[0115] Spray drying extraction technology: mainly used to convert liquid extracts into solid powders for easy storage and transportation.

[0116] The key feature is that it is not used directly in the extraction process, but rather in the post-extraction processing steps.

[0117] In practical applications, the extraction method described above is selected based on the actual situation for the extraction of the composition.

[0118] Optionally, the above extraction methods can be combined to further extract the effective elements in the formula.

[0119] For ease of explanation, the following uses the extraction combination method for specific illustration.

[0120] Combination 1: Ethanol extraction and ultrasonic extraction.

[0121] Step 1: Ethanol extraction method.

[0122] Ethanol was initially used as a solvent to dissolve and extract the target substance.

[0123] Ethanol extraction can effectively separate most of the target components and is relatively inexpensive.

[0124] Step 2: Ultrasonic extraction method.

[0125] Based on ethanol extraction, ultrasonic extraction is used to further extract residues or incompletely extracted components.

[0126] The high efficiency and short extraction time of ultrasonic extraction can effectively compensate for the shortcomings of ethanol extraction and improve the overall extraction rate.

[0127] Combination 2: Microwave-assisted extraction technology and ethanol extraction (or ultrasonic extraction).

[0128] Step 1: Microwave-assisted extraction technology.

[0129] First, microwave-assisted extraction technology is used to rapidly heat and release the target components.

[0130] This method is suitable for substances that require rapid extraction and are temperature-sensitive.

[0131] Step 2: Ethanol extraction or ultrasonic extraction.

[0132] The residues after microwave treatment were then further extracted using ethanol extraction or ultrasonic extraction.

[0133] If higher extraction purity and more comprehensive component extraction are required, ethanol extraction can be selected; if higher extraction efficiency and shorter extraction time are desired, ultrasonic extraction can be selected.

[0134] To further illustrate this, we will compare the effects of ethanol extraction, ultrasonic extraction, and ultrasonic extraction on the extraction of active ingredients.

[0135] Taking the composition of this application as an example, the components in the composition were extracted using ethanol extraction, ultrasonic extraction, and ethanol extraction and ultrasonic extraction methods, respectively, as follows: Figure 4 As shown. Figure 4 A line graph comparing another hair loss prevention composition based on extraction technology provided in this embodiment of the present disclosure.

[0136] Figure 4 It is indicated that the combination of ethanol extraction and ultrasonic extraction methods results in a much higher extraction efficiency of the active ingredients in the composition than either extraction method alone. Therefore, the composition provided in this application preferentially employs the extraction method combining ethanol extraction and ultrasonic extraction.

[0137] Optionally, the polysaccharides, anthraquinone compounds, cellulose, minerals, lecithin, and ginsenosides in the Polygonum multiflorum can be obtained through the extraction.

[0138] Optionally, the anthocyanin content in the black goji berries obtained by the extraction is approximately 8 mg / g to 30 mg / g.

[0139] This disclosure discloses an anti-hair loss composition based on extraction technology. The raw materials of the composition include: Polygonum multiflorum, mulberry, Polygonatum sibiricum, black beans, black rice, black goji berries, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives. The ratio of Polygonum multiflorum, mulberry, Polygonatum sibiricum, black beans, black rice, black goji berries, prickly pear, Codonopsis pilosula, raspberry, Rehmannia glutinosa, and trace additives is 7:1:1:1:1:1:1:1:1:1:1:4. Experiments have shown that the composition formed according to the above formula can improve the resistance of hair follicles to dihydrotestosterone, increase the self-repair ability of hair follicles, and allow atrophied or dormant hair follicles to re-enter the growth phase, thereby promoting hair growth. Furthermore, the composition of this application also has the effect of reducing hair loss.

[0140] Compared with existing technologies, the composition provided in this application can both reduce the amount of hair loss and increase the amount of hair growth. Therefore, the composition of this application has a strong effect in the fields of preventing hair loss and promoting hair growth. In addition, the raw materials in this application are basically traditional Chinese medicine formulas, which have high acceptance.

[0141] This application provides a method for preparing an anti-hair loss composition based on extraction technology, used to prepare the composition described in any one of the above-mentioned claims, the method comprising:

[0142] S101. Take Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black wolfberry, prickly pear, Codonopsis pilosula, raspberry, and Rehmannia glutinosa according to the preset ratio, crush them, and use ethanol extraction method. The extraction temperature is 40±5℃, the extraction pressure is atmospheric pressure, the extraction method is ethanol reflux extraction, and the reflux number is 4-6 times to obtain product A1.

[0143] S102. The undissolved portions of the Polygonum multiflorum, mulberry, Polygonatum sibiricum, black bean, black rice, black wolfberry, prickly pear, Codonopsis pilosula, raspberry, and Rehmannia glutinosa in the solution are extracted by ultrasonic extraction to obtain product A2.

[0144] S103, mix A1 and A2, and enzymatically hydrolyze them with dextranase for 4-6 hours, then enzymatically hydrolyze them with protease for 4-6 hours, and then sterilize to obtain product A3. Add the trace additives according to the proportion to obtain product A4.

[0145] This application provides a hair loss prevention tea based on extraction technology, characterized in that the tea includes the composition described in any one of the first aspects and instant green tea, wherein the mass ratio of the composition to the instant green tea is 5:1, and the hair loss prevention tea is prepared after thorough mixing.

[0146] The tea beverages used in this application are selected based on actual needs, and no specific restrictions are imposed here.

[0147] In practical applications, the product corresponding to the solution of this application can be a beverage, food, or other form, as long as the main components of this application are the same as the composition provided in this application. Further details are omitted here. No limitations are imposed as long as the desired results of the technical solution disclosed herein can be achieved.

[0148] The specific embodiments described above do not constitute a limitation on the scope of protection of this disclosure. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this disclosure should be included within the scope of protection of this disclosure.

Claims

1. An anti-hair loss composition based on extraction technology, characterized in that, Raw materials of the composition include: Radix Polygoni Multiflori, Morus, Rhizoma Polygonati, Black Bean, Black Rice, Black Wolfberry, Rose Apple, Codonopsis, Raspberry, Radix Rehmanniae Preparata, and trace additives; The proportions of the Radix Polygoni Multiflori, Morus, Rhizoma Polygonati, Black Bean, Black Rice, Black Wolfberry, Rose Apple, Codonopsis, Raspberry, Radix Rehmanniae Preparata, and trace additives are 7:1:1:1:1:1:1:1:1:1:4 in turn. The Radix Polygoni Multiflori, Morus, Rhizoma Polygonati, Black Bean, Black Rice, Black Wolfberry, Rose Apple, Codonopsis, Raspberry, Radix Rehmanniae Preparata, and trace additives are extracted to obtain effective substances.

2. The hair loss prevention composition based on extraction technology according to claim 1, characterized in that, The trace additives at least include sea cucumber peptide, protein, walnut peptide, sunflower seed oil, riboflavin, nicotinic acid, pantothenic acid, and selenium zinc trace elements.

3. The hair loss prevention composition based on extraction technology according to claim 2, characterized in that, The proportions of the sea cucumber peptide, protein, walnut peptide, sunflower seed oil, riboflavin, nicotinic acid, pantothenic acid, and selenium zinc trace elements are 8:5:2:1:1:1:1:1 in turn.

4. The hair loss prevention composition based on extraction technology according to claim 3, characterized in that, The composition further includes metal trace elements, which at least include at least one of zinc, iron, and copper.

5. The extractive technology based hair loss preventing composition according to claim 1, wherein The extraction is at least one of ethanol extraction, ultrasonic extraction, microwave-assisted extraction technology, and spray drying extraction technology.

6. The extractive technology based hair loss preventing composition according to claim 1, wherein The polysaccharide, anthraquinones, cellulose, mineral substances, lecithin, and ginsenosides in the Radix Polygoni Multiflori are obtained through the extraction.

7. The extractive technology based hair loss preventing composition according to claim 1, wherein The anthocyanin content in the Black Wolfberry is about 8 mg / g to 30 mg / g through the extraction.

8. A process for the preparation of a composition for the prevention of hair loss based on extraction techniques, for the preparation of the composition according to any one of claims 1 to 7, characterized by, The method includes: The Radix Polygoni Multiflori, Morus, Rhizoma Polygonati, Black Bean, Black Rice, Black Wolfberry, Rose Apple, Codonopsis, Raspberry, and Radix Rehmanniae Preparata are taken according to preset proportions, crushed, and subjected to ethanol extraction with an extraction temperature of 40±5℃, an extraction pressure of normal pressure, an extraction mode of ethanol reflux extraction, and a refluxing number of 4-6 times to obtain product A1; The undissolved parts in the solution of the Radix Polygoni Multiflori, Morus, Rhizoma Polygonati, Black Bean, Black Rice, Black Wolfberry, Rose Apple, Codonopsis, Raspberry, and Radix Rehmanniae Preparata are subjected to ultrasonic extraction to obtain product A2; A1 and A2 are mixed, subjected to enzymolysis using glucanase for 4-6 h, then subjected to enzymolysis using protease for 4-6 h, and then sterilized to obtain product A3, and the trace additives are added according to the proportions to obtain product A4.

9. An extractive technique based hair loss prevention tea drink, characterized in that, The tea drink includes the composition according to any one of claims 1-7 and instant green tea, and the mass ratio of the composition to the instant green tea is 5:

1. After sufficient mixing, an anti-hair loss tea drink is prepared.

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