Preparation method of bioactive glass collagen composite material
By adding a uniformly mixed bioactive glass and neutral salt to a collagen solution, the problem of uneven mixing between bioactive glass and collagen was solved, resulting in a uniform bioactive glass-collagen composite material suitable for structures similar to natural bone tissue in the human body, while also reducing production costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-06
- Publication Date
- 2026-03-10
AI Technical Summary
When bioactive glass is directly mixed with collagen, it tends to settle, resulting in uneven mixing and making it difficult to prepare uniform bioactive glass-collagen composite materials.
First, bioactive glass is uniformly mixed with neutral salt, then added to collagen solution. A uniform precipitate is formed through salting out. Subsequently, the precipitate is filtered, washed to remove salt, and then freeze-dried to prepare a uniform composite material.
It achieves uniform mixing of bioactive glass and collagen to form a composite material with a structure similar to natural bone tissue, which is easy to mass-produce and reduces costs.
Smart Images
Figure CN121623015A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to medical materials, in particular to a bioactive glass collagen composite material and a preparation method thereof. BACKGROUND
[0002] Type I collagen is a fiber-forming collagen, which is the main structural macromolecule of the extracellular matrix of multicellular organisms, and is very important for maintaining the integrity of bone structure and bone biomechanical properties.
[0003] Bioactive glass is a kind of silicate heterologous bone graft material, which has unique properties different from other bioactive materials, and has good bonding properties with bone and soft tissue. When bioactive glass is implanted into a bone defect site, a rapid ion exchange reaction occurs between the bioactive glass and the body fluid, forming a layer of carbonate-containing hydroxyapatite on the surface of the bioactive glass, and through the hydroxyapatite layer, the material forms a firm chemical bond with the bone. SUMMARY
[0004] The present application provides a bioactive glass collagen composite material, which comprises bioactive glass and collagen mixed together. Natural bone tissue is generated by biomineralization with collagen as a template. The bioactive glass collagen composite material can form a structure similar to natural bone tissue in the human body.
[0005] For the preparation of the above composite material, the commonly used method is to take bioactive glass and collagen respectively, and mix them together. In the preparation process, we found that bioactive glass and collagen are easy to settle when mixed directly, which leads to uneven mixing. Therefore, we propose a preparation method of bioactive glass collagen composite material, which comprises the following steps: 1) taking a collagen solution; 2) taking bioactive glass and uniformly mixing it with a neutral salt to obtain a mixture; 3) adding the mixture to the collagen solution to obtain a precipitate, which comprises bioactive glass, collagen and residual neutral salt; 4) filtering out the precipitate and washing it thoroughly to remove the neutral salt; thus obtaining the bioactive glass collagen composite material. By adding uniformly mixed bioactive glass and neutral salt to the collagen solution to salting out collagen (the whole process is completed instantly when the precipitate is precipitated), a uniformly mixed composite material can be obtained. It is emphasized that the bioactive glass and the neutral salt should be mixed uniformly first and then added to the collagen solution, otherwise it is difficult to obtain a uniformly mixed composite material.
[0006] The method further comprises the following step: 5) placing the precipitate after sufficient washing into a mold of a specific shape and freeze-drying.
[0007] Further refining the above technical solution, in step 2), a mixer or a ball mill is used to uniformly mix the bioactive glass and the neutral salt together.
[0008] Further refining the above technical solution, the neutral salt is sodium chloride or ammonium sulfate.
[0009] The present application has the advantages of reasonable design, ingenious concept, and the composite material can form a structure similar to natural bone tissue in the human body. The composite material prepared by the above method has uniform mixing of the bioactive glass and the collagen.
[0010] The above method is easy to mass-produce, the salting-out process is a process in the preparation of collagen, and the ball milling is a process in the preparation of bioactive glass. The composite material and the raw materials can be combined to effectively reduce the cost. BRIEF DESCRIPTION OF DRAWINGS
[0011] Figure 1 is a flow chart of a method for preparing a bioactive glass collagen composite material. DETAILED DESCRIPTION
[0012] As shown in the figure, a method for preparing a bioactive glass collagen composite material, the method comprising the following steps: 1) Take a collagen solution; 2) Take bioactive glass, and uniformly mix it with sodium chloride using a ball mill to obtain a mixture; 3) Add the mixture to the collagen solution under stirring to obtain a precipitate, the precipitate comprising bioactive glass, collagen, and residual sodium chloride; 4) Filter out the precipitate and wash it thoroughly to remove the sodium chloride; 5) Put the thoroughly washed precipitate into a mold of a specific shape and freeze-dry it; Thus, a bioactive glass collagen composite material is obtained.
[0013] The above is only a preferred specific embodiment of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art, according to the technical solution and the inventive concept of the present application, can make equivalent replacements or changes within the technical scope disclosed by the present application, which should be covered within the protection scope of the present application.
Claims
1. A bioactive glass collagen composite material, characterized by, The composite material comprises bioactive glass and collagen, and the bioactive glass is mixed with the collagen.
2. A method of making a bioactive glass collagen composite material, characterized by, The method comprises the following steps: 1) taking a collagen solution; 2) taking bioactive glass and uniformly mixing the bioactive glass with a neutral salt to obtain a mixture; 3) adding the mixture into the collagen solution to obtain a precipitate, and the precipitate comprises bioactive glass, collagen and residual neutral salt; 4) filtering out the precipitate and sufficiently washing to remove the neutral salt; to obtain a bioactive glass collagen composite material.
3. The method of claim 2, wherein the bioactive glass collagen composite is prepared by the steps of: The method further comprises the following step: 5) placing the sufficiently washed precipitate into a mold with a specific shape and freeze-drying.
4. The method of claim 2, wherein the bioactive glass collagen composite is prepared by the steps of: In step 2), a mixer or a ball mill is used to uniformly mix the bioactive glass with the neutral salt.
5. The method of claim 2, wherein the bioactive glass collagen composite is prepared by the steps of: The neutral salt is sodium chloride or ammonium sulfate.