Civil small molecule water and quality evaluation method and medical application thereof

Abstract

The invention discloses civil small-molecule water and a quality evaluation method and medical application thereof, compared with raw water, the civil small-molecule water has the advantages that the concentration increment of deuterium free radical ions in the civil small-molecule water is 0.2-0.6 ppm, and the variable quantity of the ratio of oxygen isotope < 18 > O is-0.6 to-1.6. Free hydrogen free radical ions and hydrogen isotope deuterium free radical ions in the small-molecule water are high in seepage force and dissolving capacity and weakly acidic and act on scaly stones in the kidney of a kidney stone patient, so that the surfaces of the stones are dissolved, and when the sizes of the stones become small and the stones are easily discharged out of a body along with urine of a urinary system, the scaly stone removing effect is achieved; the medicine can act on small molecular fragments forming thrombus, such as D-dimer and fibrin degradation products, in blood, so that fibrinolysis of the small molecular fragments is smaller, the small molecular fragments can penetrate through the nanoscale aperture of the glomerular filtration membrane to enter the urinary system of the kidney more easily, the content of the small molecular fragments forming thrombus in the blood is reduced, and vein and arterial thromboembolism is prevented.

Description

Technical Field

[0001] This invention relates to a type of small molecule water for civilian use, a method for evaluating the quality of the small molecule water for civilian use, and its medical applications. Background Technology

[0002] Hydrogen and oxygen atoms in water molecules readily form hydrogen bonds. Water in everyday life is typically composed of clusters of 15-20 water molecules linked together by hydrogen bonds, commonly known as large water clusters. However, other substances in water, such as minerals, can break these weaker hydrogen bonds, causing the water molecules to aggregate into smaller clusters. This results in smaller water clusters (small molecule water) composed of fewer than 10 water molecules.

[0003] Currently, oxygen-17 is widely used internationally. 17 Water molecules with a full width at half maximum (FWHM) of 90 Hz or less are considered small water molecules. However, this criterion is not accurate because water molecule conformational clusters are connected by hydrogen bonds. To describe whether there are any breaks in the hydrogen bonds, it is necessary to explain whether there are any changes in the size of the water molecule conformational clusters.

[0004] Furthermore, the human body's physiological functions cannot function without water. Liquid water serves as the carrier for replenishing the body's fluids and nutrients, transporting essential nutrients to various physiological systems, such as saliva, gastric juice, sweat, body fluids, blood, and the urinary system. In the urinary system, when the concentration of substances that form scale and stones, such as calcium (hardness salt ions), oxalic acid, and uric acid, brought in by the liquid water carrier, is too high, exceeding the solubility of the urinary system (i.e., supersaturation), crystalline plaques will naturally precipitate. The wrinkled structures within the kidneys in the urinary system easily trap dirt and deposits, and when these deposits crystallize, they form kidney stones, primarily composed of calcium oxalate stones (70-80%). Kidney stones with a diameter greater than 3mm begin to affect kidney function in the urinary system. Once the stones reach a diameter greater than 3mm, they can easily cause inflammation due to friction against the inner wall of the kidney, and in severe cases, can lead to uremia and kidney failure.

[0005] Currently, the treatment methods for kidney stones are: firstly, physical surgery to break and remove the stones; secondly, using a liquid water carrier to deliver a specific drug to the kidneys in the urinary system, where the drug reacts with the kidney stones to dissolve them, gradually reducing their size and allowing them to be excreted in the urine. The disadvantage of this method is that the stone-dissolving drug carried by the carrier must pass through the gastrointestinal system before reaching the urinary system, which may have side effects on other physiological systems.

[0006] The human circulatory system can be understood as a highly complex, relatively closed-loop system composed of a pumping power source (heart), a network of blood vessels (arteries and veins), blood substances (hematopoietic substances, nutrients, and the carrier "water"), and local drainage systems (kidneys, sweat system). The three key elements ensuring the normal functioning of the circulatory system are flow rate, pressure, and velocity. Three main factors influence blood velocity: the strength of the heart's pumping power; the resistance naturally generated by the accumulation of solid impurities in the inner walls of arteries and veins, and the dynamic resistance generated by soluble solids (fibrinolytic impurities); and the flow rate, velocity, and properties of the carrier "water" in the blood. Resistance that reduces blood velocity is the root of many diseases; altering the properties and velocity of the carrier "water" is equivalent to increasing blood velocity, making it the primary method of disease prevention. Therefore, under certain conditions of relatively stable blood flow and blood pressure, reducing vascular network resistance, increasing blood velocity, and improving the renal membrane filtration rate (removing blood impurities) are crucial elements for the normal functioning of the human circulatory system.

[0007] In the blood system, substances that make up blood, including fibrin, red blood cells, and platelets, gradually accumulate on the inner walls of blood vessels (such as veins) to form thrombi, resulting in conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE), among others. If a DVT thrombus breaks off and travels through the bloodstream, it can obstruct the pulmonary artery, causing PE, which can be life-threatening. The human body possesses a robust fibrinolytic system that produces substances (such as plasmin) that, like digestive juices, slowly dissolve the main component of the thrombus—fibrin. This process occurs at the site of the embolism. The resulting fragments (such as D-dimer) are soluble small molecules that can be carried away by the blood and excreted in urine through filtration by the kidneys. Therefore, clinically, the levels of D-dimer and fibrin(ogen) degradation products in the blood can be used to indirectly determine whether a thrombus has formed or dissolved, while the glomerular filtration rate reflects the kidneys' ability to remove blood impurities.

[0008] Prevention is far more important than treatment. VTE prevention includes basic prevention (avoiding prolonged immobilization, drinking plenty of water), mechanical prevention (elastic stockings, IPC), and pharmacological prevention (anticoagulants). If the "water therapy" in basic prevention can enhance the fibrinolytic capacity of the fibrinolytic system, allowing D-dimer (molecular weight approximately 195 kDa) to be cleaved into smaller soluble fragments (such as the DD / E complex, approximately 100–130 kDa) by plasmin, these fragments can more effectively pass through the glomerular filtration membrane of the kidneys and enter the urinary system. This not only prevents the formation and detachment of DVT emboli but also avoids the high costs and risks associated with other preventative and treatment measures. Summary of the Invention

[0009] The first objective of this invention is to provide a small molecule water for civilian use that can remove scale and stones and reduce the probability of thromboembolism.

[0010] The first objective of this invention is achieved through the following technical solution: a type of small-molecule water for civilian use, characterized in that, compared to raw water, the concentration increase of deuterium free radical ions in the small-molecule water is 0.2–0.6 ppm, and the oxygen isotope concentration is also increased. 18 The ratio of O changes from -0.6 to -1.6.

[0011] Free hydrogen in small molecule water (This invention) 1 H) free radical ions and hydrogen isotope deuterium (D) free radical ions have strong penetrating and dissolving power, and are weakly acidic. They act on the scale-like stones in the kidneys of patients with kidney stones, dissolving the surface of the stones. As the stone volume decreases, it is more easily excreted with urine from the urinary system, thus achieving the effect of removing scale and stones. Moreover, they act on small molecular fragments that form "thrombi" in the blood, such as D-dimer and fibrin(ogen) degradation products, making them fibrinoly dissolve into smaller particles. These smaller particles can more easily penetrate the nanoscale pores (70-100nm) of the glomerular filtration membrane and enter the urinary system of the kidneys, thereby reducing the content of these small molecular fragments forming "thrombi" in the blood and preventing the incidence of venous and arterial thromboembolism.

[0012] The raw water described in this invention is pure packaged drinking water.

[0013] The civilian small molecule water described in this invention is produced by treating raw water through a paramagnetic resonance energy field.

[0014] The second objective of this invention is to provide a method for evaluating the quality of the aforementioned civilian small molecule water.

[0015] The second objective of this invention is achieved through the following technical solution: a method for evaluating the quality of the aforementioned civilian small molecule water, characterized in that, firstly, the concentration of deuterium free radical ions and oxygen isotopes in the water to be tested are detected. 18 The ratio of O is then used to calculate the increase in deuterium radical ion concentration and oxygen isotope content compared to the original water. 18 The change in the ratio of O, when the concentration increase of deuterium radical ions is 0.2–0.6 ppm, and the oxygen isotope 18 When the change in the ratio of O is between -0.6 and -1.6, the water to be tested is determined to be the aforementioned civilian small molecule water.

[0016] By detecting changes in the ratio of the hydrogen isotope deuterium, the quantity of individual deuterium and hydrogen radical ions in raw water and processed aquatic products can be reflected. This demonstrates the phenomenon of hydrogen bonds being broken by external energy forces. If the relative increase in the number of free hydrogen (deuterium) radical ions directly proves that the conformational clusters of water molecules have become smaller. Therefore, detecting and evaluating the quantity of free hydrogen (deuterium) radical ions in small molecule water can serve as a quality indicator for evaluating changes in the aquatic physical structure of small molecule water. Thus, this invention limits the increase in the concentration of deuterium radical ions and the oxygen isotope... 18 The method of determining small molecule water by the change in the ratio of O is not only simple and easy to implement, but also highly accurate.

[0017] A third objective of this invention is to provide a medical application of the aforementioned civilian small molecule water.

[0018] The third objective of this invention is achieved through the following technical solution: a medical application of the above-mentioned civilian small molecule water, characterized in that the civilian small molecule water is given to patients with kidney stones for drinking to remove scale and stones.

[0019] The small molecule water of this invention is for civilian use and can be drunk by patients with kidney stones. It can remove scale and stones and has the characteristics of high efficiency, painlessness, no drug side effects and low cost. It is the best choice for the treatment of kidney stones.

[0020] The present invention provides a kidney stone particle size ≤7mm in the body of patients with kidney stones.

[0021] The third objective of this invention is achieved through the following technical solution: a medical application of the above-mentioned civilian small molecule water, characterized in that the civilian small molecule water is provided to patients with venous thromboembolism and arteriosclerosis to reduce the probability of thromboembolism.

[0022] The civilian-use small molecule water of this invention is intended for patients with venous thromboembolism (VTE) and arteriosclerosis (atherosclerotic plaques). It can reduce the D-dimer content in the blood, reduce fibrin(ogen) degradation products, and increase glomerular filtration rate. It can prevent blood embolic accidents caused by the formation and detachment of DVT emboli. It is characterized by high efficiency, painlessness, no drug side effects, and low cost, making it the optimal choice for preventing venous VTE, DVT, PE, and arteriosclerotic embolism.

[0023] The present invention addresses the D-dimer content in the blood of patients with venous thromboembolism and arteriosclerosis ≤1800μg / L, of which 500~1800μg / L is considered a low-risk area, and drug prophylaxis and mechanical prophylaxis should be used in combination.

[0024] The recommended daily intake of the small molecule water for civilian use described in this invention is 1000ml to 3000ml.

[0025] Compared with the prior art, the present invention has the following significant effects:

[0026] (1) This invention limits the concentration increment of deuterium radical ions and oxygen isotopes. 18 The method of determining small molecule water by the change in the ratio of O is not only simple and easy to implement, but also highly accurate.

[0027] (2) This invention uses the concentration increment of deuterium radical ions and oxygen isotopes 18 The change in the ratio of O to water is used to determine whether a substance is small molecule water. This method has been scientifically demonstrated and the mechanism is clear. Therefore, this invention can reproducibly and accurately determine whether a substance is small molecule water.

[0028] (3) Free hydrogen in small molecule water of the present invention ( 1 H) free radical ions and hydrogen isotope deuterium (D) free radical ions have strong penetrating and dissolving power, and are weakly acidic. They act on the scale-like stones in the kidneys of patients with kidney stones, dissolving the surface of the stones. As the stone volume decreases, it is more easily excreted with urine from the urinary system, thus achieving the effect of removing scale and stones. They also act on small molecular fragments that form "thrombi" in the blood, such as D-dimer and fibrin(ogen) degradation products, making them fibrinoly dissolve into even smaller particles. These smaller particles can more easily penetrate the nanoscale pores (70-100nm) of the glomerular filtration membrane and enter the urinary system of the kidneys, thereby reducing the content of these small molecular fragments forming "thrombi" in the blood and preventing the incidence of venous and arterial thromboembolism.

[0029] (4) Kidney stone patients can drink the small molecule water of this invention, which has altered the conformation of water molecules, as a carrier. The water flows through the patient's urinary system to the kidneys to achieve the effect of removing scale and stones. It has the advantages of high efficiency, painlessness, no side effects, and low cost. It is especially suitable for kidney disease patients with kidney stone particle size φ≤ stone size. The kidney stone removal rate can reach 15-40%.

[0030] (5) Patients with venous thromboembolism (VTE) and arteriosclerosis (atherosclerotic plaques) can drink the small-molecule water of this invention, which alters the conformation of water molecules, as a carrier. This water flows through the patient's blood system and can prevent deep vein thrombosis (DVT) and embolic events (such as PE) caused by the detachment of DVT emboli. It can also prevent embolic events caused by the accidental accumulation of excessive D-dimer and fibrin(ogen) degradation products in the aortic (heart, brain) vessel walls due to plaque cracks. When the drinking water therapy is implemented within a D-dimer content range of 0–1800 μg / L, during a treatment period of 1–3 months, the D-dimer content decrease rate is ≤0%; the fibrin(ogen) degradation product decrease rate is ≤0%; and the glomerular filtration rate (estimated value) increase rate is ≤0%.

[0031] (6) This invention has a very significant breakthrough in the principle demonstration and development of the entire physical and chemical preparation of small molecule water.

[0032] (7) This invention is of great medical significance in exploring an efficient, low-risk, and low-cost anticoagulant thrombolysis (blood-activating and stasis-removing) prevention pathway. Attached Figure Description

[0033] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0034] Figure 1 This is a medical application example 1 of the present invention: a CT image of both kidneys of a patient with kidney stones before drinking civilian small molecule water.

[0035] Figure 2 This is a medical application example of the present invention: a CT image of the kidneys of a patient with kidney stones after drinking the civilian small molecule water according to the course of treatment. Detailed Implementation

[0036] A type of small-molecule water for civilian use, compared to raw water, exhibits an increase in the concentration of deuterium free radical ions of 0.2–0.6 ppm, and oxygen isotopes… 18 The ratio of O changes from -0.6 to -1.6.

[0037] The raw water is pure packaged drinking water. The civilian small molecule water of this invention is produced by treating the raw water through a paramagnetic resonance energy field. The water treatment process is characterized by the raw water being treated ≥ the number of times it passes through the energy field. The paramagnetic resonance energy field can be the paramagnetic resonance field device of Chinese Patent (ZL 201110057303.3). This device includes a shell with an inlet and an outlet. A paramagnetic resonance field spacer is provided between the inlet and outlet of the shell. The paramagnetic resonance field consists of at least one set of paramagnetic resonance field effect disks, each set consisting of two disks facing each other and sandwiching permanent magnets and connected by bolts passing through a central hole. The surface of the paramagnetic resonance field effect disk has a central hole and an eccentric water passage hole. Positioning annular bosses are provided around both ends of the central hole. The back of the disk surface is corrugated.

[0038] One of the above-mentioned methods for evaluating the quality of civilian small molecule water first involves detecting the concentration of deuterium (D) radical ions and oxygen isotopes in the water to be tested. 18 The ratio of O is then used to calculate the increase in deuterium radical ion concentration and oxygen isotope concentration compared to the original water. 18 The change in the ratio of O, when the increase in the concentration of deuterium radical ions is 0.2–0.6 ppm, and the oxygen isotope 18 When the change in the O ratio is between -0.6 and -1.6, the water being tested is determined to be domestically produced small-molecule water. (Oxygen isotopes) 18 The ratio of O refers to 18 O and 16 Isotope ratios of O (ordinary oxygen).

[0039] A medical application of the above-mentioned civilian small molecule water is to provide the civilian small molecule water to patients with kidney stones for drinking in order to remove scale and stones, and it is suitable for patients with kidney stones with a particle size diameter ≤7mm.

[0040] One medical application of the above-mentioned civilian small molecule water is to provide the civilian small molecule water to patients with early (low-risk area) venous thromboembolism (VTE) and arteriosclerosis (atherosclerotic plaques) for drinking in order to prevent anticoagulation and thrombus dissolution (promote blood circulation and remove blood stasis), and it is suitable for patients whose blood D-dimer content is ≤1800μg / L.

[0041] The recommended daily intake of small molecule water for civilian use is 1000ml to 3000ml.

[0042] The research and development mechanism of this invention is: under the external force of a high-energy physical energy field, the water molecule conformation of the raw water changes. and water molecule conformation clusters The n-value of a water molecule decreases due to external forces, meaning the hydrogen bonds connecting the conformation and clusters of water molecules are broken. While the conformation of the water molecule decreases, some individual hydrogen atoms also break. 1 H) radical ions and deuterium (D) radical ions exist outside the conformation and clusters of water molecules. It is these free hydrogen (H) radical ions that are free outside the conformation and clusters of water molecules. 1 The presence of H and deuterium (D) free radical ions is necessary to demonstrate the existence of the special functionalities of small molecule water (weak acidity, permeability, and solubility), to explain the significant decrease in the content of fibrinolytic impurities in the blood, to reflect the possibility that deep vein thrombosis (DVT) "emboli" are gradually dissolved, and to prevent the incidence of thromboembolic accidents caused by the accumulation of soluble solids (fibrinolytic impurities) due to plaque rupture in arteriosclerosis (atherosclerotic plaques).

[0043] When small water molecules conform to clusters As the n-value decreases, the water quality undergoes unique physical property changes. For example, the dielectric constant and dielectric loss (energy) decrease by 50% and 53% (average) respectively compared to the original water before treatment, as shown in the attached figure of the water quality test report in Chinese Patent (ZL201110057303.3). This indicates that small molecule water experiences reduced running resistance and increased flow rate under relatively liquid flow conditions. Therefore, using small molecule water as a carrier "water" to enter the blood system can achieve a relatively higher blood flow rate. Prediction: In the field of traditional Chinese medicine for promoting blood circulation (such as ginkgolide, total saponins of Panax notoginseng, paeonol, hirudin, etc.), choosing small molecule water as a "guide water" has a synergistic effect (1+1>2); drinking small molecule water during the recovery period of male sexual dysfunction can provide a "rejuvenating" experience. These medical application areas all have the value and broad market prospects for in-depth research and development of civilian small molecule water.

[0044] Examples of small molecule water quality testing:

[0045] The raw water used in this example was purified packaged drinking water. Ingredients: Natural water; water quality characteristics: calcium ≥ 4.0 mg / L; magnesium ≥ 0.5 mg / L; potassium ≥ 0.35 mg / L; sodium ≥ 0.8 mg / L; metasilicic acid ≥ 1.8 mg / L. The raw water (A) was treated N times (N ≥ 1) using a paramagnetic resonance energy field device, resulting in treated water (civilian small molecule water) with different N values, designated B and C. Three sets of water samples were taken from both the pre- and post-treatment water samples for testing. The test results are shown in Tables 1-5.

[0046]

[0047] (Table 1)

[0048]

[0049] (Table 2)

[0050]

[0051] (Table 3)

[0052]

[0053] (Table 4)

[0054]

[0055] (Table 5)

[0056] After completing the testing procedures in Table 1, the three groups of water samples—raw water (No. A) and treated water (No. B and C)—were stored at 4°C for 12 days to obtain the raw water (No. A - 12 days) and treated water (No. B - 12 days, No. C - 12 days) samples in Table 2. After being stored at the same temperature for another 100 days, the water samples before treatment (No. A - 100 days) and after treatment (No. B - 100 days, No. C - 100 days) samples in Table 3 were obtained.

[0057] The detection equipment used in the above tests is an isotope ratio mass spectrometer (main unit) and an elemental analyzer (external equipment). The detection methods are as follows:

[0058] Hydrogen isotope principle: After the sample is subjected to high-temperature pyrolysis in an elemental analyzer to generate H2, the mass spectrometer detects the hydrogen isotope content. 2 H(D) and 1 The H ratio was calculated by comparing it with the international standard reference material (SMOW) and then determining the d of the sample. 2 H(dD) ratio value.

[0059] Oxygen isotope principle: After a sample is subjected to high-temperature pyrolysis in an elemental analyzer to generate CO, the mass spectrometer detects the CO... 18 O and16 The O ratio was calculated by comparing the sample with the international standard reference material (SMOW) and then determining the d of the sample. 18 O value.

[0060] Measurement accuracy: d 18 O: ± < 0.2‰.

[0061] Case Study:

[0062] 1. Calculation of the increase in hydrogen and deuterium (concentration ppm)

[0063] Based on the detection data in Table 1, the ratio of hydrogen isotope deuterium (D) changed from -33.6 (average) in the raw water (A) before treatment to -29.8 (average) in the treated small molecule water (C). This resulted in a change in deuterium concentration from 150.5265 ppm (average) to 151.1184 ppm (average). Therefore, the increase in deuterium free radical ions was 0.5919 ppm. Based on a deuterium to hydrogen ratio of 1:6600, the free hydrogen in the treated small molecule water (…) 1 The increase in H) radical ions is equivalent to approximately 3905.88 ppm. And oxygen isotopes... 18 The ratio of O changed from -5.3 (average) to -3.725 (average), which gives a change of -1.575 (average), as shown in Table 6:

[0064] (Table 6)

[0065] 2. Timeliness of small molecule aquatic products for civilian use

[0066] Based on the trend of the rate of change in the test data in Tables 1, 2, and 3, the storage period for civilian small molecule aquatic products at an ambient temperature of 4℃±2 is approximately 21 days.

[0067] 3. Repeatability of water quality testing

[0068] Based on the comparison of the test data in Tables 1, 4, and 5, the trend of the change rate after testing of water samples from different batches is consistent, indicating the repeatability and accuracy of this water quality testing method.

[0069] Medical Application Example 1:

[0070] The method for detecting the effectiveness and calculating the removal rate of the small-molecule water provided to patients with kidney stones in this example is as follows:

[0071] 1. First, go to a qualified medical institution to have a CT scan of both kidneys to confirm the number and size of kidney stones.

[0072] 2. A drinking water course lasts for 60 days. The average daily intake of small molecule water is 1500ml to 3000ml, which may vary depending on individual body weight. It can be consumed heated or at room temperature.

[0073] 3. After completing one course of water therapy, have a CT scan of both kidneys at the same medical institution. Since CT images can reflect the actual number of kidney stones, comparing the results of the two CT scans before and after drinking small molecule water can accurately calculate the kidney stone removal rate of drinking small molecule water.

[0074] Case Study:

[0075] A kidney stone patient underwent a bilateral renal CT scan at a hospital in Guangzhou before drinking small molecule water. The bilateral renal CT images are shown below. Figure 1 Kidney stone 1 is the highlighted spot in the image. Specific details regarding bilateral kidney stones are shown in Tables 7 and 8.

[0076]

[0077] (Table 7)

[0078]

[0079] (Table 8)

[0080] After a three-month period of water therapy, the patient returned to the same hospital in Guangzhou for a follow-up CT scan. The CT images of both kidneys showed… Figure 2 The specific details of bilateral kidney stones are shown in Tables 9 and 10:

[0081] (Table 9)

[0082]

[0083] (Table 10)

[0084] Based on the changes in kidney stones observed in two CT scans, it can be concluded that the removal rate of kidney stones in patients with kidney stones treated with the small molecule water described in this case was approximately 37%.

[0085] Calculation of stone removal rate in the example:

[0086] The number of stones removed from the right kidney in patients with kidney stones = 10 stones before the water therapy (see Table 7) - 6 stones after the water therapy (see Table 8) = 4 stones, and the right kidney stone removal rate = 40%;

[0087] The number of stones removed from the left kidney of patients with kidney stones = 6 stones before the water therapy (see Table 9) - 4 stones after the water therapy (see Table 10) = 2 stones, and the removal rate of left kidney stones = 33.33%.

[0088] Medical Application Example 2:

[0089] In this case, the small molecule water was given to patients with venous thromboembolism (VTE) with a daily intake of 1000ml to 3000ml for 80 consecutive days as one course of treatment.

[0090] A patient suffered from long-term hyperhemoglobinemia (Hb measured at 136-189) and hyperthrombocytopenia (PLT count at 456-931), resulting in varicose veins and peripheral capillary stasis in the right ankle (localized dark bruising on the skin), and early signs of deep vein thrombosis (DVT). The following table compares blood test results from several hospitals in Guangzhou before and after the interventional "water drinking" therapy, including fibrinolysis markers (DDi+FDP):

[0091]

[0092] (Table 11)

[0093] Case Analysis:

[0094] 1. During one treatment course (≈80 days), both fibrinolytic parameters (DDi + FDP) decreased by 60% (DDi) and 65.6% (FDP), indicating that the hydrogen content in a certain amount of the blood carrier "water" (DDi + FDP) decreased. 1 H) and deuterium (D) free radical ions have a significant effect on enhancing the fibrinolytic capacity of human blood.

[0095] 2. Sixty days after the patient began the water therapy, they experienced recurring episodes of swelling and pain in their right ankle and calf, indicating that venous thrombosis had occurred during this period, with emboli dislodging and blocking the veins. With intervention using medication (aspirin, rivaroxaban) and mechanical methods (infrared light, mid-frequency physiotherapy), the swelling, pain, and thrombosis typically disappeared naturally within 1-3 days. It is anticipated that the fibrinolytic phase and emboli dislodgement phase of the primary venous thrombosis will recur intermittently over a relatively long period (6 months), as evidenced by fluctuations in D-dimer levels.

[0096] Medical Application Example 3:

[0097] In this case, the small molecule water was provided for patients with arteriosclerosis to drink, with a daily intake of 1000ml to 3000ml, and a course of treatment lasting 60 days.

[0098] A patient with arteriosclerosis (atherosclerosis) had a total cholesterol (TC) level of 5.82 mmol / L and a low-density lipoprotein cholesterol level of 3.5 mmol / L, and did not choose to take preventative medication. The following table compares the blood test results (DDi + FDP) from a Guangzhou hospital before and after the interventional "water drinking" therapy:

[0099]

[0100] (Table 12)

[0101] Case Analysis:

[0102] After 40 days of water-based therapy, the D-dimer level decreased by 62.5%, indicating a significant potential for improvement in the fibrinolytic capacity of the blood system. The glomerular filtration rate, already high (93.91% before intervention), continued to increase (95.13% after intervention), demonstrating that changes in the blood carrier "water" enhance the kidney's blood cleansing ability.

[0103] Medical Application Example 4:

[0104] In this case, the small molecule water was provided for patients with arteriosclerosis to drink, with a daily intake of 1000ml to 3000ml, for a course of treatment lasting 60 days.

[0105] A patient with arteriosclerosis (atherosclerosis) had a total cholesterol (CHOL) of 7.00 mmol / L and a low-density lipoprotein cholesterol (LDL-C) of 3.85 mmol / L. The patient was taking statins daily as prescribed for prevention. The following table compares the blood test results (DDi + FDP) from a hospital in Guangzhou before and after the intervention of the "water therapy" program.

[0106]

[0107] (Table 13)

[0108] Case Analysis:

[0109] 1. The D-dimer level increased by 16.67% after the intervention compared to before the intervention, indicating that thrombi in the blood vessels were fibrinoly dissolved, which may be related to long-term use of statins.

[0110] 2. The glomerular filtration rate increased by 19.97%, indicating that the change in the blood carrier "water" does indeed have the advantage of improving kidney function.

Claims

1. A small molecule water for civilian use, characterized by: Compared with raw water, the concentration increment of deuterium radical ion in the small-molecule water for civil use is 0.2-0.6 ppm, and the variation of the ratio of oxygen isotopes 18 O is -0.6--1.

6.

2. The small molecule water for civil use according to claim 1, characterized in that: The raw water is pure packaged drinking water.

3. The small molecule water for civil use according to claim 2, characterized by: The small-molecule water for civilian use is prepared by treating raw water through paramagnetic resonance energy field.

4. The method for evaluating the quality of small-molecule water for civilian use according to any one of claims 1 to 3, characterized by: First, the concentration of deuterium radical ion and oxygen isotope in the water to be measured is detected 18 O ratio, and then the increment of deuterium radical ion concentration and oxygen isotope compared with the original water is calculated 18 O ratio, and when the increment of deuterium radical ion concentration is 0.2-0.6 ppm, and the oxygen isotope 18 O ratio is -0.6 to -1.6, it is determined that the water to be measured is the civil small molecule water.

5. The medical use of the small-molecule water for human consumption according to any one of claims 1 to 3, characterized in that: The small-molecule water for civilian use is used for kidney stone patients to remove scale and stones.

6. The medical use of civil small molecule water according to claim 5, characterized by the fact that: The size of kidney stone particles in kidney stone patients is ≤7mm in diameter.

7. The medical use of civil small molecule water according to claim 6, characterized by the fact that: The drinking amount of the small-molecule water for civilian use is 1000ml-3000ml per day.

8. The medical use of the civil small-molecule water according to any one of claims 1 to 3, characterized by: The small-molecule water for civilian use is used for patients with venous thromboembolism and arteriosclerosis to reduce the risk of thromboembolism.

9. The medical use of civil small molecule water according to claim 8, characterized by the fact that: The blood D-dimer content in patients with venous thromboembolism and arteriosclerosis is ≤1800μg / L.

10. The medical use of the small-molecule water for human consumption according to claim 9, characterized by the fact that it is used in the treatment of: The drinking amount of the small-molecule water for civilian use is 1000ml-3000ml per day.

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