Stress inducible virus and application thereof
By using stress-induced viruses to achieve controlled release of therapeutic proteins, the problems of insufficient targeting and systemic side effects in OSCC treatment have been solved, achieving highly efficient and personalized local treatment results.
CN121628850APending Publication Date: 2026-03-10SICHUAN UNIV
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Patent Information
- Application Number
- CN202511894157.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-16
- Publication Date
- 2026-03-10
AI Technical Summary
Technical Problem
Existing OSCC treatment regimens suffer from problems such as insufficient targeting, severe systemic toxicity, and uncontrollable drug release, resulting in poor efficacy and high safety risks.
Method used
Develop stress-induced viruses containing specific nucleic acid sequences to achieve controlled release of therapeutic proteins through external physical stimuli (such as temperature), locally activate their expression, and avoid systemic side effects.
Benefits of technology
This enables personalized, tunable, and precise release of therapeutic proteins, reducing systemic toxicity and improving therapeutic efficacy.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of medicine and biology, and particularly discloses a stress-inducible virus and application thereof.The stress-inducible virus comprises a stress-inducible adenovirus or a stress-inducible lentivirus, the nucleotide sequence of the stress-inducible adenovirus or the stress-inducible lentivirus is shown as SEQ ID NO: 1, and the nucleotide sequence of the stress-inducible adenovirus or the stress-inducible lentivirus is shown as SEQ ID NO: 2. The preparation method comprises the following steps: constructing a virus vector, wherein the virus vector has a nucleotide sequence as shown in SEQ ID NO: 1; and virus packaging: transfecting HEK293T cells by adopting shuttle plasmids containing SEQ ID NO: 1 and skeleton plasmids containing viral genome sequences, and collecting a virus stock solution to obtain the stress induced virus. The invention also discloses application of the stress-induced virus in preparation of medicines for preventing and treating oral tumors. Controllable release of the foreign protein under a specific signal is realized. The therapeutic protein produced by the invention can maximize the curative effect of drugs such as CD47 targeted protein and the like, and meanwhile, the toxic and side effects of the drugs on other tissues of the whole body are reduced.
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