Reactive oxygen concentration control method and brain-computer interface implant accelerated life test system

Abstract

The application relates to an active oxygen concentration control method and an accelerated life test system of a brain-computer interface implant, and the accelerated life test system is used for testing the electrochemical performance of the brain-computer interface implant by using a test solution. The method comprises the following steps: detecting a current feedback current corresponding to a current test solution; obtaining a current active oxygen concentration according to the current feedback current and a preset active oxygen concentration-current relationship function; generating a filling parameter according to a concentration difference between the current active oxygen concentration and a preset active oxygen concentration; and adding hydrogen peroxide solution to the current test solution according to the filling parameter, so that the current test solution reaches the preset active oxygen concentration. The application can simulate the active oxygen environment generated by the immune response in the living body through the test solution, can accurately control the active oxygen concentration in the test solution, and improves the accuracy of the test result of the brain-computer interface implant.

Description

TECHNICAL FIELD

[0001] The present application mainly relates to the technical field of brain-computer interface implant test, in particular to an active oxygen concentration control method and a brain-computer interface implant accelerated life test system. BACKGROUND

[0002] The in-vitro life test of brain-computer interface implant is a common method to simulate physiological environment and evaluate the expected service life of the implant, which is crucial for the safety and effectiveness of medical devices. In order to shorten the test period, the accelerated life test method based on the relationship between temperature and material reaction rate is usually used.

[0003] The active oxygen produced by the immune response in the living body can accelerate the aging of the implant, and the existing accelerated life test method does not consider the influence factor of active oxygen. For invasive brain-computer interface implants, it is difficult to meet the accuracy requirements of in-vitro evaluation by temperature regulation only. The existing brain-computer interface implant test method has the problem of inaccurate test results. SUMMARY

[0004] The technical problem to be solved by the present application is to provide an active oxygen concentration control method and a brain-computer interface implant accelerated life test system, which can simulate the active oxygen environment produced by the immune response in the living body through the test solution, accurately regulate the active oxygen concentration in the test solution, and improve the accuracy of the test results of the brain-computer interface implant.

[0005] The technical solution adopted by the present application to solve the above technical problem is an active oxygen concentration control method applicable to an accelerated life test system of a brain-computer interface implant, wherein the accelerated life test system is used to test the electrochemical performance of the brain-computer interface implant using a test solution; the method comprises: detecting a current feedback current corresponding to a current test solution; obtaining a current active oxygen concentration according to the current feedback current and a preset active oxygen concentration-current relationship function; generating an injection parameter according to the concentration difference between the current active oxygen concentration and a preset active oxygen concentration; and adding hydrogen peroxide solution to the current test solution according to the injection parameter, so that the current test solution reaches the preset active oxygen concentration.

[0006] In an embodiment of the present application, the accelerated life test system comprises an electrochemical detection device, the electrochemical detection device comprises a counter electrode and a working electrode; the preset active oxygen concentration and current function is constructed by the following operations: step Sa: obtaining a preset concentration as a current preset concentration from a preset active oxygen concentration range, preparing a test solution conforming to the current preset concentration, and immersing the counter electrode and the working electrode in the test solution; step Sb: controlling the counter electrode to cyclically output a square wave voltage within a first preset time; step Sc: collecting a current value corresponding to the square wave voltage through the working electrode; step Sd: filtering the current value by using a filtering function to obtain a feedback current within a second preset time before a high level ends, the second preset time being less than the first preset time; repeatedly executing the steps Sa-Sd until all preset concentrations in the preset active oxygen concentration range are traversed; step Se: performing data fitting processing on each preset concentration in the preset active oxygen concentration range and the corresponding feedback current, thereby obtaining the preset active oxygen concentration and current function.

[0007] In an embodiment of the present application, the preset active oxygen concentration and current function comprises a curve function, and the curve function satisfies that the active oxygen concentration monotonically increases with the increase of the feedback current.

[0008] In an embodiment of the present application, the curve function is constructed by the following manner: dividing the preset active oxygen concentration range into a first concentration interval, a second concentration interval and a third concentration interval in order of concentration from small to large; in the first concentration interval, using an exponential fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a first sub curve function; in the second concentration interval, using a linear fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a second sub curve function; in the third concentration interval, using a polynomial fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a third sub curve function; using a smooth transition algorithm to connect the first sub curve function, the second sub curve function and the third sub curve function to form the curve function.

[0009] In an embodiment of the present application, the step Sb: controlling the counter electrode to cyclically output a square wave voltage within a first preset time comprises: step Sb1: controlling the counter electrode to output a square wave voltage of a first preset volt within a third preset time; step Sb2: controlling the counter electrode to output a square wave voltage of a second preset volt within a fourth preset time; repeatedly executing the steps Sb1 and Sb2 until the sum of all third preset times and all fourth preset times is greater than or equal to the first preset time.

[0010] In an embodiment of the present application, the accelerated life test system comprises an active oxygen filling device provided with a water pump, two ends of the water pump being communicated with the test solution and the hydrogen peroxide solution respectively; the filling parameter comprises a filling amount and a filling speed; the filling parameter is generated according to a concentration difference between the current active oxygen concentration and a preset active oxygen concentration, comprising: a control signal is calculated using a proportional-integral-derivative control method according to the concentration difference; the filling amount and the filling speed are generated according to the control signal, a concentration parameter of the hydrogen peroxide solution and a flow parameter of the water pump.

[0011] In an embodiment of the present application, the hydrogen peroxide solution is added into the current test solution according to the filling parameter, comprising: in response to the current active oxygen concentration being less than the preset active oxygen concentration, the water pump is instructed to add the hydrogen peroxide solution into the test solution according to the filling amount and the filling speed; or in response to the current active oxygen concentration being greater than or equal to the preset active oxygen concentration, the water pump is instructed to stop adding the hydrogen peroxide solution into the test solution.

[0012] In an embodiment of the present application, the test solution comprises salt; the method further comprises: detecting a current liquid level corresponding to the current test solution; in response to the current liquid level being less than a first preset height, adding purified water into the current test solution to make the current liquid level reach the first preset height, so that a salt concentration in the current test solution meets a preset salt concentration; and / or in response to the current liquid level being less than a second preset height, stopping heating the current test solution, the second preset height being less than the first preset height.

[0013] In an embodiment of the present application, further comprising: detecting a current solution temperature corresponding to the current test solution; in response to the current solution temperature being less than a preset solution temperature, heating the current test solution until the current solution temperature reaches the preset solution temperature, and dynamically adjusting a heating power according to a temperature difference between the current solution temperature and the preset solution temperature in the process of heating; or in response to the current solution temperature being greater than the preset solution temperature, stopping heating the current test solution so that the current solution temperature reaches the preset solution temperature.

[0014] To solve the above technical problems, the application further provides an accelerated life test system of a brain-computer interface implant, comprising: an implant test device, configured to accommodate the brain-computer interface implant and test the electrochemical performance of the brain-computer interface implant using a test solution; an electrochemical detection device, comprising a counter electrode and a working electrode, wherein the counter electrode is configured to output a square wave voltage, and the working electrode is configured to collect a current value corresponding to the square wave voltage; an active oxygen injection device, configured to inject a hydrogen peroxide solution; a liquid level sensor, configured to detect a liquid level of the test solution; a purified water injection device, configured to inject purified water; a temperature sensor, configured to detect a solution temperature of the test solution; a heating device, configured to heat the test solution; and a processor, configured to adjust the test solution using the active oxygen concentration control method described above.

[0015] The technical solution of the application can accurately obtain the current active oxygen concentration by detecting the current feedback current of the test solution and combining a preset active oxygen concentration and current relationship function, and can generate an injection parameter according to a concentration difference and supplement the hydrogen peroxide solution, thereby realizing dynamic regulation and control of the active oxygen concentration, stably maintaining the test solution at the preset active oxygen concentration, effectively simulating the active oxygen environment generated by the immune response in vivo in the process of accelerated life test of the brain-computer interface implant, providing stable test conditions for electrochemical performance test of the implant, and improving the accuracy and reliability of the life evaluation result of the brain-computer interface implant. BRIEF DESCRIPTION OF DRAWINGS

[0016] To make the above objectives, features and advantages of the application more apparent, the specific embodiments of the application are described in detail below with reference to the accompanying drawings, in which:

[0017] Figure 1 FIG. 1 is a schematic diagram of an accelerated life test system of a brain-computer interface implant according to an embodiment of the application;

[0018] Figure 2 FIG. 2 is a partial schematic diagram of an accelerated life test system of a brain-computer interface implant according to an embodiment of the application;

[0019] Figure 3 FIG. 3 is a flowchart of an active oxygen concentration control method according to an embodiment of the application;

[0020] Figure 4 FIG. 4 is a graph of the relationship between time and voltage when the counter electrode cyclically outputs a square wave voltage according to an embodiment of the application;

[0021] Figure 5 FIG. 5 is a schematic diagram of a preset active oxygen concentration and current relationship function according to an embodiment of the application;

[0022] Figure 6 FIG. 6 is a system block diagram of an active oxygen concentration control system according to an embodiment of the application.

[0023] Reference signs in the detailed description of the embodiments:

[0024] 10. Accelerated life testing system;

[0025] 11. Implant testing device;

[0026] 111. Test solution;

[0027] 112. Hydrogen peroxide solution;

[0028] 12. Electrochemical probing device;

[0029] 121. Counter electrode;

[0030] 122. Working electrode;

[0031] 123. Electrochemical work station;

[0032] 13. Active oxygen filling device;

[0033] 131. Water pump;

[0034] 132. Controller;

[0035] 14. Purified water filling device. DETAILED DESCRIPTION

[0036] In order to make the above objectives, features and advantages of the present application more clear and easily understood, the specific embodiments of the present application are described in detail below with reference to the accompanying drawings.

[0037] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, it will be apparent to one skilled in the art that the present application can be practiced without the specific details and other implementations can be employed. Thus, the present application is not limited to the embodiments disclosed below but include all alternatives falling within the scope of the present application.

[0038] As used in this application, the terms "comprises", "comprising", "includes", "including", "has", "having" or the like are intended to be inclusive of a statement of

[0039] Flow diagrams have been used herein to illustrate the operation of systems in accordance with embodiments of the present application. It will be understood that the operations as set forth in the preceding or following operations are not necessarily performed in the precise order described. Rather, various steps can be handled in reverse order or simultaneously. Additionally, or alternatively, other operations can be added or removed from these processes.

[0040] The present application uses hydrogen peroxide as a source of active oxygen to simulate the effects of the immune response in the body during the testing of brain-computer interface implants. The present application finds that adding hydrogen peroxide to the test solution can have problems including: on the one hand, hydrogen peroxide is prone to decomposition and volatilization at room temperature and under heating conditions, making it difficult to maintain a stable concentration of active oxygen in the test solution, which can interfere with the analysis of electrochemical performance; on the other hand, if there is a lack of coordinated control of liquid level, temperature and active oxygen concentration, it can also affect the accuracy and reliability of the test results of brain-computer interface implants. In order to overcome these problems, the present application designs an active oxygen concentration control scheme for the test solution in the accelerated life test system of brain-computer interface implants.

[0041] First, the accelerated life test system of brain-computer interface implants of the present application is introduced, and the active oxygen concentration control method of the present application will be described later.

[0042] Figure 1 is a schematic diagram of the accelerated life test system of brain-computer interface implants of an embodiment of the present application. Referring to Figure 1 , the accelerated life test system 10 of brain-computer interface implants of this embodiment includes an implant test device 11, an electrochemical detection device 12, an active oxygen injection device 13, a liquid level sensor (not shown in the figure), a purified water injection device 14, a temperature sensor (not shown in the figure), a heating device (not shown in the figure) and a processor (not shown in the figure), the processor is configured to execute the active oxygen concentration control method described later to adjust the test solution. Specifically, the implant test device 11 is used to accommodate a brain-computer interface implant (not shown in the figure) and test the electrochemical performance of the brain-computer interface implant using a test solution.

[0043] Figure 2 is a partial schematic diagram of the accelerated life test system of brain-computer interface implants in an embodiment of the present application. Referring to Figure 1 and Figure 2 , the electrochemical detection device 12 includes a counter electrode 121 and a working electrode 122, the counter electrode 121 is used to output a square wave voltage, and the working electrode 122 is used to collect the current value corresponding to the square wave voltage. For example, the electrochemical detection device 12 also includes an electrochemical workstation 123, the counter electrode 121 and the working electrode 122 are immersed in the test solution 111, and the electrochemical workstation 123 can control the output voltage and collect the feedback current. Figure 2 , R corresponds to a reference electrode (Reference Electrode) for providing a stable reference potential; W corresponds to a working electrode 122 (Work Electrode), which is equivalent to an electrode where the target electrochemical reaction occurs; C corresponds to a counter electrode 121 (Counter Electrode), which is used to form a current loop with the working electrode 122 to assist in the electrochemical reaction.

[0044] The active oxygen filling device 13 (provided with a water pump 131 as shown) is used to fill the hydrogen peroxide solution 112. Exemplarily, the water pump 131 can be controlled by the controller 132 to suck and thus fill the hydrogen peroxide solution 112 into the test solution 111. The liquid level sensor is used to detect the corresponding liquid level of the test solution 111. The purified water filling device 14 is used to fill purified water. The temperature sensor is used to detect the corresponding solution temperature of the test solution 111. The heating device is used to heat the test solution 111. Figure 2

[0045] Exemplarily, the test solution 111 of the present application is composed of water (such as purified water), salt (such as phosphate) and hydrogen peroxide. The accelerated life test system 10 of the brain-computer interface implant of the present application provides a stable test carrier through the implant test device 11; the output square wave voltage of the counter electrode 121 of the electrochemical detection device 12 and the current value collected by the working electrode 122 are used to supplement the hydrogen peroxide solution 112 through the active oxygen filling device 13, and the liquid level and the salt concentration of the test solution 111 are maintained according to the liquid level sensor and the purified water filling device 14; the temperature of the test solution 111 is accurately controlled through the temperature sensor and the heating device; the active oxygen concentration control method of the present application is executed by the processor to realize the coordinated control scheme of the three-way circulation of the active oxygen concentration, the liquid level and the solution temperature.

[0046] The present application can simulate the active oxygen environment generated by the immune response in vivo, and provides a physiological actual, stable and reliable and safe accelerated life test environment for the brain-computer interface implant, and improves the accuracy and reliability of the life test results of the implant.

[0047] The active oxygen concentration control method of the present application will be described hereinafter.

[0048] The present application provides an active oxygen concentration control method, which is suitable for the scenario of testing the electrochemical performance of the brain-computer interface implant by using the test solution in the accelerated life test system of the brain-computer interface implant. The active oxygen concentration control method of the present application can be run in the local end of the accelerated life test system of the brain-computer interface implant, for example, in the controller or the processor of the accelerated life test system, and can also be run in the cloud platform. When the active oxygen concentration control method is run in the cloud platform, the data of the local end of the accelerated life test system and the data of the cloud platform are interacted through the wireless network. Exemplarily, the cloud platform can include private cloud, public cloud, hybrid cloud, community cloud, distributed cloud, interconnected cloud and multiple cloud, or any combination thereof. The present application does not limit the running environment of the active oxygen concentration control method.

[0049] Figure 3 is the flowchart of the active oxygen concentration control method of an embodiment of the present application. Referring to​Figure 3 As shown, the active oxygen concentration control method of this embodiment includes the following steps:

[0050] Step S110: detecting a current feedback current corresponding to a current test solution.

[0051] Step S120: obtaining a current active oxygen concentration according to the current feedback current and a preset active oxygen concentration-current relationship function.

[0052] Step S130: generating a filling parameter according to a concentration difference between the current active oxygen concentration and a preset active oxygen concentration.

[0053] Step S140: adding hydrogen peroxide solution to the current test solution according to the filling parameter, so that the current test solution reaches the preset active oxygen concentration.

[0054] The above steps S110 to S140 are described in detail as follows:

[0055] In step S110, a current feedback current corresponding to a current test solution is detected. For example, referring to Figure 1 and Figure 2 As shown, the feedback current of the test solution 111 can be detected by the electrochemical detection device 12.

[0056] In step S120, a current active oxygen concentration is obtained according to the current feedback current and a preset active oxygen concentration-current relationship function. For example, the preset active oxygen concentration-current relationship function can be constructed in advance through experiments.

[0057] Continuing to refer to Figure 1 and Figure 2 In some embodiments, the accelerated life test system 10 includes the electrochemical detection device 12, which includes the counter electrode 121 and the working electrode 122; and the preset active oxygen concentration-current relationship function is constructed by the following operations:

[0058] Step Sa: obtaining a preset concentration (such as 0 mM or 1 mM or 2 mM, etc.) as a current preset concentration from a preset active oxygen concentration range (such as 0 mM~100 mM, mM represents millimoles per liter), preparing a test solution 111 meeting the current preset concentration, and immersing the counter electrode 121 and the working electrode 122 in the test solution 111;

[0059] Step Sb: controlling the counter electrode 121 to cyclically output a square wave voltage within a first preset time length (such as 20 s, s represents seconds);

[0060] Step Sc: collecting a current value corresponding to the square wave voltage by the working electrode 122;

[0061] Step Sd: filtering the current value by using a filter function to obtain the feedback current in a second preset time period (e.g., 1s~2s) before the high level ends, the second preset time period being less than the first preset time period; repeating the steps Sa~Sd until all preset concentrations in the preset active oxygen concentration range are traversed.

[0062] Step Se: performing data fitting processing on each preset concentration in the preset active oxygen concentration range and the corresponding feedback current, thereby obtaining the preset active oxygen concentration and current relationship function.

[0063] Figure 4 is a graph of the relationship between time and voltage when the electrode cyclically outputs a square wave voltage in an embodiment of the present application. As shown in Figure 4 , for example, in the step Sb, the cyclic output parameters of the square wave voltage can be set as t1 seconds V1 volts and t2 seconds V2 volts, for example, V1=-800mV (mV represents millivolt), t1=1s, V2=850mV, t2=4s, and the first preset time period is the total time period of the cyclic output (e.g., 20s). In the step Sd, the filter function can eliminate the interference noise of the current value corresponding signal.

[0064] The present application completes multiple data acquisition and fitting by traversing the preset active oxygen concentration range through the foregoing operations, and the active oxygen concentration and current relationship function constructed thereby can accurately reflect the corresponding relationship between the active oxygen concentration and the feedback current in the test solution, thereby providing a reliable data basis for real-time detection of the active oxygen concentration.

[0065] Continuing to refer to Figure 2 and Figure 4 , in some embodiments, the step Sb: controlling the counter electrode 121 to cyclically output a square wave voltage in a first preset time period (e.g., 20s) includes:

[0066] Step Sbl: controlling the counter electrode 121 to output a square wave voltage of a first preset volt (e.g., first preset volt V1=-800mV) in a third preset time period (e.g., third preset time period t1=1s);

[0067] Step Sb2: controlling the counter electrode 121 to output a square wave voltage of a second preset volt (e.g., second preset volt V2=850mV) in a fourth preset time period (e.g., fourth preset time period t2=4s); repeating the steps Sbl and Sb2 until the sum of all third preset time periods and all fourth preset time periods is greater than or equal to the first preset time period.

[0068] For example, the present application ensures that the working electrode 122 can collect stable current signals through the continuous cyclic output of the square wave voltage, thereby ensuring the reliability of the feedback current.

[0069] Figure 5is a schematic diagram of a preset active oxygen concentration and current relationship function in an embodiment of the present application. Referring to Figure 5 As shown in some embodiments, the preset active oxygen concentration and current relationship function includes a curve function, which satisfies that the active oxygen concentration C monotonically increases with the increase of the feedback current A. An exemplary curve function is shown in the following table: Figure 5 As shown in the curve function, as the active oxygen concentration C increases from 0 mM to 100 mM, the value of the feedback current A shows an increasing trend.

[0070] In some embodiments, the curve function is constructed in the following way:

[0071] Divide the preset active oxygen concentration range (such as 0 mM~100 mM) into a first concentration interval (such as 0 mM~20 mM), a second concentration interval (such as 20 mM~60 mM) and a third concentration interval (such as 60 mM~100 mM) in order of concentration from small to large;

[0072] In the first concentration interval, an exponential fitting algorithm is used to fit the corresponding preset concentration and feedback current, to obtain a first sub curve function;

[0073] In the second concentration interval, a linear fitting algorithm is used to fit the corresponding preset concentration and feedback current, to obtain a second sub curve function;

[0074] In the third concentration interval, a polynomial fitting algorithm is used to fit the corresponding preset concentration and feedback current, to obtain a third sub curve function;

[0075] The first sub curve function, the second sub curve function and the third sub curve function are connected by a smooth transition algorithm to form a complete curve function.

[0076] For example, the first concentration interval can be a low concentration interval, corresponding to the reaction rate limited stage, and the feedback current can show a non-linear growth, so the exponential fitting algorithm can be used; the second concentration interval can be a medium concentration interval, corresponding to the reaction rate stable stage, and the active oxygen concentration and the feedback current have an approximate linear relationship, so the linear fitting algorithm can be used; the third concentration interval can be a high concentration interval, corresponding to the reaction rate saturation stage, and the feedback current can grow slowly, so the polynomial fitting algorithm can be used; the smooth transition algorithm can eliminate the fitting breakpoints of the three types of sub curve functions at the interval boundaries, ensure the continuity and monotonicity of the entire curve function, and improve the fitting accuracy of the curve function.

[0077] In step S130, the charging parameter is generated according to the concentration difference between the current active oxygen concentration and the preset active oxygen concentration.

[0078] Referring to Figure 1 and Figure 2As shown, in some embodiments, the accelerated life test system 10 comprises an active oxygen filling device 13 provided with a water pump 131, two ends of the water pump 131 being communicated with the test solution 111 and the hydrogen peroxide solution 112 respectively; the filling parameters include a filling amount and a filling speed; the filling parameters are generated according to a concentration difference between the current active oxygen concentration and the preset active oxygen concentration, including:

[0079] The control signal is calculated according to the concentration difference using a Proportional-Integral-Derivative (PID) control method;

[0080] The filling amount and the filling speed are generated according to the control signal, the concentration parameter of the hydrogen peroxide solution, and the flow parameter of the water pump.

[0081] For example, the flow parameter of the water pump can be the delivery amount per unit time; the concentration parameter of the hydrogen peroxide solution can be set to 10 mM to 30 mM. The present application dynamically calculates the control signal according to the concentration difference between the current active oxygen concentration C and the preset active oxygen concentration C SET , and accurately calculates the required filling amount (i.e. the total amount of hydrogen peroxide solution required to compensate for the concentration difference) and the filling speed (i.e. the filling amount per unit time) by combining the flow parameter of the water pump and the concentration parameter of the hydrogen peroxide solution. Through the cooperative calculation of the PID control method and multiple parameters, the present application can generate accurate filling parameters, avoid concentration fluctuations caused by overfilling or underfilling, and achieve smooth filling of the hydrogen peroxide solution 112 through stable delivery of the water pump 131, thereby ensuring the stability of the active oxygen concentration in the test solution 111.

[0082] In step S140, the hydrogen peroxide solution is added to the current test solution according to the filling parameters, so that the current test solution reaches the preset active oxygen concentration. Referring to Figure 2 As shown, in some embodiments, the filling parameters include:

[0083] In response to the current active oxygen concentration C being less than the preset active oxygen concentration C SET , the water pump 131 is instructed to add the hydrogen peroxide solution 112 to the test solution 111 according to the filling amount and the filling speed;

[0084] Alternatively, in response to the current active oxygen concentration C being greater than or equal to the preset active oxygen concentration C SET , the water pump 131 is instructed to stop adding the hydrogen peroxide solution 112 to the test solution 111.

[0085] For example, step S140 is equivalent to "active oxygen concentration cycle logic". When the electrochemical detection device detects that C < C SETWhen C < C SET , it indicates that the active oxygen concentration in the current test solution is insufficient, and the hydrogen peroxide solution needs to be supplemented by the water pump according to the calculated filling amount and filling speed; when C ≥ C SET , it indicates that the active oxygen concentration has met the test requirements, and the water pump is instructed to stop filling to avoid excessive active oxygen concentration. The present application can realize on-demand replenishment of hydrogen peroxide solution, avoid excessive or insufficient active oxygen concentration, ensure that the active oxygen concentration in the test solution always maintains in an appropriate range, and ensure the stability of the test environment.

[0086] In some embodiments, the test solution includes salt, such as phosphate buffered saline (PBS). The active oxygen concentration control method further includes:

[0087] detecting a current liquid level corresponding to the current test solution;

[0088] in response to the current liquid level being less than a first preset height, adding purified water to the current test solution to make the current liquid level reach the first preset height, so that the salt concentration in the current test solution meets a preset salt concentration;

[0089] and / or, in response to the current liquid level being less than a second preset height, stopping heating the current test solution, the second preset height being less than the first preset height.

[0090] For example, the above steps correspond to "liquid level sensor cycle logic". The test solution of the present application is composed of water, salt and hydrogen peroxide, the first preset height Lup is a preset upper limit of the liquid level, and the second preset height Llow is a preset lower limit of the liquid level. During the electrochemical performance test of the brain-computer interface implant, water evaporation will cause the liquid level of the test solution to drop, thereby increasing the salt concentration and affecting the accuracy of electrochemical signal acquisition. Therefore, when the liquid level is less than the first preset height Lup, purified water is added through a purified water filling device until the liquid level returns to the first preset height Lup to maintain a constant salt concentration; to avoid dry burning risk, when the liquid level is less than the second preset height Llow (warning lower limit), the heating device is controlled to stop heating and an alarm signal is sent.

[0091] The present application can maintain a constant salt concentration in the test solution, avoid abnormal salt concentration interference with electrochemical signal acquisition and active oxygen concentration detection, also realize dry burning protection and alarm function, and improve the safety of the test process.

[0092] In some embodiments, the active oxygen concentration control method further includes:

[0093] detecting a current solution temperature corresponding to the current test solution;

[0094] In response to the current solution temperature being less than the preset solution temperature, heating the current test solution until the current solution temperature reaches the preset solution temperature, and dynamically adjusting the heating power according to a temperature difference between the current solution temperature and the preset solution temperature during the heating process;

[0095] Alternatively, in response to the current solution temperature being greater than the preset solution temperature, stopping heating the current test solution so that the current solution temperature reaches the preset solution temperature.

[0096] For example, the above steps correspond to "temperature sensor cycle logic", when the temperature sensor detects that the current solution temperature is lower than the preset solution temperature, the heating device is started and the heating power is dynamically adjusted according to the temperature difference: for example, when the temperature difference is large, high power heating is adopted; when the temperature difference is small, low power heating is adopted to avoid rapid temperature rise. When the current solution temperature is higher than the preset solution temperature, the heating device is stopped to make the temperature fall to the preset solution temperature.

[0097] The temperature control of the present application can be based on the way of water bath heating and PID algorithm control, and the preset solution temperature can be set to the interval of 20℃-87℃, which can adapt to the high temperature requirement of the accelerated life test of the brain-computer interface implant, and thus the implant life test at a speed of up to 32 times can be realized. The present application can realize accurate test solution temperature control, avoid temperature fluctuation leading to rapid decomposition of hydrogen peroxide, and provide a good environmental basis for the stability of active oxygen concentration; at the same time, through the cooperation of temperature control, active oxygen concentration control and liquid level control, a stable test environment is constructed, which can meet the accelerated life test requirement of the brain-computer interface implant.

[0098] Reference Figure 1 and Figure 2 As shown in the figures, the following describes the accelerated life test process of the brain-computer interface implant according to a complete embodiment of the present application.

[0099] 1. Pre-configuration stage. Add a test solution 111 containing salt to the implant test device 11, inject purified water through the purified water injection device 14, detect the current liquid level height by the liquid level sensor, until the liquid level reaches the first preset height, and complete the pre-configuration.

[0100] 2. Electrochemical performance test stage. Set the preset active oxygen concentration, the preset solution temperature, the first preset height, the second preset height, the test duration and other parameters. Add hydrogen peroxide solution 112 to the test solution 111 through the active oxygen injection device 13 to construct a test environment containing active oxygen. Start the heating device to heat the test solution 111, and detect the current solution temperature by the temperature sensor.

[0101] 3. Monitoring cycle and test environment maintenance stage.

[0102] (1) Active oxygen concentration cycle control is performed. The counter electrode 121 of the electrochemical detection device 12 cyclically outputs a square wave voltage, and the working electrode 122 collects the corresponding current value. The current value is processed using a filter function to obtain a feedback current, and the current active oxygen concentration is obtained by combining a preset active oxygen concentration and current relationship function. According to the concentration difference between the current active oxygen concentration and the preset active oxygen concentration, the PID control method is used to generate the injection parameter. If the current active oxygen concentration is less than the preset active oxygen concentration, the water pump 131 is instructed to add hydrogen peroxide solution 112 to the test solution 111 according to the injection parameter; if the current active oxygen concentration is greater than or equal to the preset active oxygen concentration, the water pump 131 is instructed to stop adding hydrogen peroxide solution 112.

[0103] (2) Liquid level sensor cycle control is performed. The current liquid level of the test solution 111 is continuously detected by the liquid level sensor. If the current liquid level is less than the first preset height, purified water is added to the test solution 111 by the purified water injection device 14 to make the liquid level reach the first preset height, so as to maintain the constant salt concentration.

[0104] (3) Temperature sensor cycle control is performed. The current solution temperature of the test solution 111 is continuously detected by the temperature sensor. If the current solution temperature is less than the preset solution temperature, the test solution 111 is heated and the heating power is dynamically adjusted according to the temperature difference; if the current solution temperature is greater than the preset solution temperature, the test solution 111 is stopped heating.

[0105] 4. Safety protection stage. The current liquid level of the test solution 111 is continuously detected by the liquid level sensor, and if the current liquid level is less than the second preset height, the test solution 111 is immediately stopped heating and an alarm signal is sent.

[0106] 5. Electrochemical performance test end stage. When the test duration reaches the preset duration, the test is stopped, and the heating device and all injection devices are stopped, and the test solution 111 is discharged through the drainage device.

[0107] The present application can produce the following beneficial effects:

[0108] (1) Closed-loop control of active oxygen concentration is achieved. By combining electrochemical detection method and PID liquid supplement control method, the active oxygen concentration in the test solution can be stably maintained, and the accuracy of the test results is improved.

[0109] (2) The immune environment in the body is effectively simulated. By introducing active oxygen, the limitations of traditional tests relying only on temperature regulation are broken, and the test environment is closer to the real physiological immune state in the body, improving the reliability of implant life evaluation.

[0110] (3) It can adapt to high-temperature accelerated test scenarios. The present application supports test environments such as 20℃-87℃, can achieve implant body life test at a speed of 32 times, and can meet the actual needs of implant body rapid life evaluation.

[0111] The present application also includes an active oxygen concentration control system comprising a memory and a processor. The memory is used to store instructions executable by the processor; the processor is used to execute the instructions to implement the active oxygen concentration control method described above.

[0112] Figure 6 is a system block diagram of the active oxygen concentration control system of an embodiment of the present application. Referring to Figure 6 The active oxygen concentration control system 600 can include an internal communication bus 601, a processor 602, a read-only memory (ROM) 603, a random access memory (RAM) 604, and a communication port 605. The active oxygen concentration control system 600 can also include a hard disk 606. The internal communication bus 601 can enable data communication between the components of the active oxygen concentration control system 600. The processor 602 can make judgments and issue prompts. In some embodiments, the processor 602 can be composed of one or more processors. The communication port 605 can enable data communication between the active oxygen concentration control system 600 and the outside. In some embodiments, the active oxygen concentration control system 600 can send and receive information and data from the network through the communication port 605. The active oxygen concentration control system 600 can also include different forms of program storage units and data storage units, such as the hard disk 606, the read-only memory (ROM) 603, and the random access memory (RAM) 604, which can store various data files used by the computer processing and / or communication, and possible program instructions executed by the processor 602. The processor executes these instructions to implement the main part of the method. The results of the processor processing are transmitted to the user equipment through the communication port and displayed on the user interface.

[0113] The active oxygen concentration control method described above can be implemented as a computer program, stored in the hard disk 606 and loaded into the processor 602 for execution, to implement the active oxygen concentration control method of the present application.

[0114] The present application also includes a computer readable medium storing computer program code, which, when executed by a processor, implements the active oxygen concentration control method described above.

[0115] When the active oxygen concentration control method is implemented as a computer program, it can also be stored in a computer-readable storage medium as an article of manufacture. For example, the computer-readable storage medium can include, but is not limited to, magnetic storage devices (e.g., hard disk, floppy disk, magnetic strips), optical disks (e.g., compact disk (CD), digital versatile disk (DVD)), smart cards, and flash memory devices (e.g., electrically erasable programmable read only memory (EPROM), card, stick, key drive). Additionally, the various storage mediums described herein can represent one or more devices and / or other machine-readable media for storing information. The term "machine-readable medium" can include, without limitation, wireless channels and various other media (and / or storage media) that are capable of storing, containing, and / or carrying code and / or instructions and / or data.

[0116] It should be understood that the embodiments described above are only illustrative. The embodiments described herein can be implemented in hardware, software, firmware, middleware, microcode, or any combination thereof. For a hardware implementation, the processors can be implemented within one or more application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, controllers, micro-controllers, microprocessors, and / or other electronic units designed to perform the functions described herein, or a combination thereof.

[0117] Some aspects of the present application can be performed entirely in hardware, entirely in software (including firmware, resident software, microcode, etc.), or in a combination of hardware and software. The above hardware or software can be referred to as a "block", "module", "engine", "unit", "component", or "system". The processor can be one or more application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processor devices (DAPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, controllers, micro-controllers, microprocessors, or a combination thereof. In addition, aspects of the present application can be manifested as computer products in one or more computer-readable media including computer-readable codes. For example, the computer-readable media can include, but are not limited to, magnetic storage devices (e.g., hard disk, floppy disk, magnetic tape...), optical disks (e.g., compact disk (CD), digital versatile disk (DVD)...), smart cards, and flash memory devices (e.g., card, stick, key drive...).

[0118] A computer readable medium can include a propagated data signal with computer program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated signal can take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any combination thereof. Computer readable media can be any media that can be accessed by a computer. By way of example, and not limitation, such computer readable media can comprise RAM, ROM, EEPROM, CD-ROM or any combination thereof. The computer program product can be tangibly embodied in an information carrier. The computer program product can also contain instructions that, when executed, perform one or more methods, such as those described above. The computer program product can be tangibly embodied in an information carrier code that can be accessed by a machine and that can cause the machine to perform a series of operations. The operations described above can be implemented as code of any appropriate type on a machine-readable medium.

[0119] The foregoing description has been described in accordance with the underlying concepts. It is apparent that those skilled in the art can make various modifications, improvements and changes to the application disclosed above only as examples, but not as a limitation to the application. Although the above description does not explicitly state, those skilled in the art can make various modifications, improvements and changes to the application. Such modifications, improvements and changes are suggested in the application, so such modifications, improvements and changes still belong to the spirit and scope of the exemplary embodiments of the application.

[0120] Meanwhile, specific words have been used in the present application to describe the embodiments of the present application. As "one embodiment", "an embodiment", and / or "some embodiments" means a certain feature, structure or characteristic related to at least one embodiment of the present application. Therefore, it should be emphasized and noted that the "one embodiment" or "one embodiment" or "one alternative embodiment" mentioned in different places in the specification does not necessarily refer to the same embodiment. In addition, some features, structures or characteristics in one or more embodiments of the present application can be properly combined.

[0121] Some embodiments use numbers to describe components, attributes, and quantities. It should be understood that such numbers used in the description of the embodiments are, in some examples, modified by the words "about", "approximately", or "generally". Unless otherwise stated, "about", "approximately", or "generally" indicates that the stated number can vary by ±20%. Accordingly, in some embodiments, numerical parameters used in the application are approximations that can vary depending on the desired characteristics of the individual embodiments. In some embodiments, numerical parameters should be considered in the context of the number of significant digits and accurate to the number of significant digits. Although the numerical ranges and parameters in some embodiments of the present application are approximate values, in specific embodiments, such numerical values are set as precisely as possible within the feasible range.

Claims

1. A method of controlling the concentration of active oxygen, characterized by, An accelerated life test system suitable for a brain-computer interface implant, the accelerated life test system being used for testing electrochemical performance of the brain-computer interface implant using a test solution; the method comprising: detecting a current feedback current corresponding to a current test solution; obtaining a current active oxygen concentration according to the current feedback current and a preset active oxygen concentration-current relationship function; generating a filling parameter according to a concentration difference between the current active oxygen concentration and a preset active oxygen concentration; adding hydrogen peroxide solution to the current test solution according to the filling parameter, so that the current test solution reaches the preset active oxygen concentration.

2. The active oxygen concentration control method according to claim 1, wherein The accelerated life test system comprises an electrochemical detection device, the electrochemical detection device comprising a counter electrode and a working electrode; the preset active oxygen concentration-current relationship function is constructed by the following operations: Step Sa: obtaining a preset concentration as a current preset concentration from a preset active oxygen concentration range, preparing a test solution conforming to the current preset concentration, and immersing the counter electrode and the working electrode in the test solution; Step Sb: controlling the counter electrode to cyclically output a square wave voltage within a first preset time length; Step Sc: collecting a current value corresponding to the square wave voltage through the working electrode; Step Sd: filtering the current value by using a filtering function to obtain a feedback current within a second preset time length before a high level ends, the second preset time length being less than the first preset time length; repeatedly executing the steps Sa-Sd until all preset concentrations in the preset active oxygen concentration range are traversed; Step Se: performing data fitting processing on each preset concentration in the preset active oxygen concentration range and the corresponding feedback current, thereby obtaining the preset active oxygen concentration-current relationship function.

3. The active oxygen concentration control method according to claim 2, wherein The preset active oxygen concentration-current relationship function comprises a curve function, and the curve function satisfies that the active oxygen concentration monotonically increases with the increase of the feedback current.

4. The active oxygen concentration control method according to claim 3, wherein The curve function is constructed in the following way: dividing the preset active oxygen concentration range into a first concentration interval, a second concentration interval and a third concentration interval in order of concentration from small to large; in the first concentration interval, using an exponential fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a first sub curve function; in the second concentration interval, using a linear fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a second sub curve function; in the third concentration interval, using a polynomial fitting algorithm to fit the corresponding preset concentration and feedback current to obtain a third sub curve function; using a smooth transition algorithm to connect the first sub curve function, the second sub curve function and the third sub curve function to form the curve function.

5. The active oxygen concentration control method according to claim 2, wherein The step Sb: controlling the counter electrode to cyclically output a square wave voltage within a first preset time length, comprises: Step Sb1: controlling the counter electrode to output a square wave voltage of a first preset volt within a third preset time length; Step Sb2: controlling the counter electrode to output a second preset voltage square wave voltage in a fourth preset time length; repeating the step Sb1 and the step Sb2 until the sum of all third preset time lengths and all fourth preset time lengths is greater than or equal to the first preset time length.

6. The active oxygen concentration control method according to claim 1 or 2, characterized by, The accelerated life test system comprises an active oxygen filling device provided with a water pump, two ends of the water pump being communicated with the test solution and the hydrogen peroxide solution respectively; the filling parameters comprise a filling amount and a filling speed; The filling parameters are generated according to a concentration difference between the current active oxygen concentration and a preset active oxygen concentration, comprising: The control signal is calculated using a proportional-integral-derivative control method according to the concentration difference; The filling amount and the filling speed are generated according to the control signal, a concentration parameter of the hydrogen peroxide solution and a flow parameter of the water pump.

7. The active oxygen concentration control method according to claim 6, wherein The hydrogen peroxide solution is added to the current test solution according to the filling parameters, comprising: In response to the current active oxygen concentration being less than the preset active oxygen concentration, the water pump is instructed to add the hydrogen peroxide solution to the test solution according to the filling amount and the filling speed; or In response to the current active oxygen concentration being greater than or equal to the preset active oxygen concentration, the water pump is instructed to stop adding the hydrogen peroxide solution to the test solution.

8. The active oxygen concentration control method according to claim 1, wherein The test solution comprises salt; the method further comprises: Detecting a current liquid level corresponding to the current test solution; In response to the current liquid level being less than a first preset height, adding purified water to the current test solution to make the current liquid level reach the first preset height, so that the salt concentration in the current test solution meets a preset salt concentration; and / or In response to the current liquid level being less than a second preset height, stopping heating the current test solution, the second preset height being less than the first preset height.

9. The active oxygen concentration control method according to claim 1, wherein Further comprising: Detecting a current solution temperature corresponding to the current test solution; In response to the current solution temperature being less than a preset solution temperature, heating the current test solution until the current solution temperature reaches the preset solution temperature, and dynamically adjusting a heating power according to a temperature difference between the current solution temperature and the preset solution temperature during the heating; Or In response to the current solution temperature being greater than the preset solution temperature, stopping heating the current test solution so that the current solution temperature reaches the preset solution temperature.

10. An accelerated life testing system for a brain computer interface implant, comprising: Comprising: An implant test device for accommodating the brain-computer interface implant and testing the electrochemical performance of the brain-computer interface implant using a test solution; An electrochemical detection device comprising a counter electrode and a working electrode, the counter electrode being used to output a square wave voltage, and the working electrode being used to collect a current value corresponding to the square wave voltage; An active oxygen filling device for filling hydrogen peroxide solution; A liquid level sensor for detecting a liquid level corresponding to the test solution; A purified water filling device for filling purified water; A temperature sensor for detecting a solution temperature corresponding to the test solution; A heating device for heating the test solution; a processor configured to adjust the test solution using the active oxygen concentration control method of any of claims 1-9.

Images