Miniature peristaltic device for directional regeneration of deep cranial nerves and preparation method of miniature peristaltic device
By employing shape memory alloy wire actuation and biocompatible materials in the micro-peristaltic device, combined with a surface wrinkled structure, the problem of stable and directional regeneration of the peristaltic device in deep brain nerve regions has been solved, achieving safe peristalsis and degradability design in complex environments.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-02
- Publication Date
- 2026-03-13
AI Technical Summary
Existing peristaltic devices are susceptible to external factors and may damage biological tissues, especially when used in deep brain nerve regions.
A miniature peristaltic device is designed, using shape memory alloy wire as the driving structure, combined with a surface wrinkled structure and a biodegradable shell. Peristaltic movement is achieved through current control, avoiding external interference from magnetic drive, and biocompatible materials are used for degradation to ensure stable and directional regeneration in deep brain nerve regions.
Stable peristalsis was achieved in deep brain nerve regions, avoiding scratching damage to surrounding tissues. The degradable material avoids the risk of long-term retention, improving the safety and reliability of the directional regeneration process.
Smart Images
Figure CN121647847A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of peristaltic technology, specifically to a miniature peristaltic device for targeted regeneration of deep brain nerves and its preparation method. Background Technology
[0002] Peristalsis is a way for organisms such as earthworms and parasites to move efficiently in narrow spaces. Its characteristics are that the wave-like forward propulsion is generated by the sequential contraction and relaxation of body segments, which has little disturbance to the environment and a large traction force. Imitating this movement mechanism is of great significance for the development of micro-peristaltic devices suitable for complex in vivo environments. Micro-peristaltic devices are devices that use shape memory alloy materials and are driven by electric current to deform, thereby realizing peristalsis. They have many advantages such as high efficiency of movement, precise control, and good biocompatibility.
[0003] Currently, most peristaltic devices are magnetically driven peristaltic micro-devices that are susceptible to external factors and may damage biological tissues. To address this, we propose a micro-peristaltic device for targeted regeneration of deep brain nerves and its preparation method. Summary of the Invention
[0004] (a) Technical problems to be solved
[0005] To address the shortcomings of existing technologies, this invention provides a micro-peristaltic device for targeted regeneration of deep brain nerves and its preparation method, which solves the problem that most existing peristaltic micro-devices driven by magnets are easily affected by external factors and may damage biological tissues.
[0006] (II) Technical Solution
[0007] To achieve the above objectives, the present invention provides the following technical solution: a micro-peristaltic for targeted regeneration of deep brain nerves, comprising a micro-peristaltic with a pleated structure on its surface and a driving structure inside. The micro-peristaltic is worm-shaped and consists of two C-shaped structures. Combined with the continuous annular pleated structure on its surface, it can simulate the efficient peristaltic movement of organisms in narrow spaces. This not only adapts to the complex lumen and tissue gaps in deep brain nerve regions but also avoids scratching damage to surrounding soft tissues during peristalsis. At the same time, the pleated structure provides stable waveform power for movement, ensuring flexible movement in the delicate neural environment.
[0008] Furthermore, the driving structure is a shape memory alloy wire. By using shape memory alloy wire as the driving structure, its contraction and recovery deformation are precisely controlled by current, thus overcoming the drawbacks of traditional magnetic drives that are easily affected by external environmental interference. Even in the complex biomagnetic field environment inside the body, it can still achieve stable peristalsis. Moreover, the shape memory alloy wire is wrapped with a polyimide insulating coating, which can avoid electrical interference with internal components, further ensuring driving stability and ensuring accurate delivery to the target area of deep brain nerves.
[0009] Furthermore, by controlling the shape memory alloy wire with electric current, the wire can be contracted and restored to its original shape when power is cut off, thereby driving the micro-peristaltic device to generate peristaltic motion.
[0010] Furthermore, the outer shell of the micro-peristaltic device is made of a biocompatible and biodegradable material, specifically one of polyethylene glycol diacrylate, silk fibroin, or gelatin-methacrylamide hydrogel. After use, it can be naturally degraded through biological metabolism, avoiding the risk of long-term retention in the body. The outer shell is made of biocompatible and biodegradable materials such as polyethylene glycol diacrylate, silk fibroin, or gelatin-methacrylamide hydrogel. After use, it can be gradually degraded through the body's natural metabolism, eliminating the need for secondary surgery to remove it. This completely avoids the risks of inflammation, rejection, and other complications that may be caused by long-term retention of traditional non-degradable devices in the body, and is especially suitable for applications in sensitive tissue areas such as deep brain nerves.
[0011] Furthermore, the micro-peristaltic has an overall worm-like structure, composed of two C-shaped structures.
[0012] Furthermore, the edges of the wrinkled structure on the surface of the micro-peristaltic shell are rounded with a radius of 2-5 μm to avoid scratching damage to the soft tissues around the brain nerves during peristalsis. The biomimetic peristaltic shell is formed by mature micro-nano 3D printing technology, which can accurately process the preset wrinkled structure and C-shaped main body shape, with high manufacturing efficiency and controllable size. After assembly, the core parameters such as peristaltic performance and positioning accuracy can be tested through an in vitro control platform, without the need for complicated in vivo debugging procedures, reducing the difficulty of research and development and production, and making it easier to translate into clinical applications.
[0013] Furthermore, the shape memory alloy wire is wrapped with an insulating coating made of polyimide. In addition to the core functional components, the lubricating coating sprayed on the outer shell can further reduce the coefficient of friction with biological tissues and reduce movement resistance. The hollow channel reserved inside can accommodate wires or transmit saline solution, providing auxiliary support for the stability of the component. The overall design ensures the applicability and reliability of the micro-peristaltic device in the scenario of targeted regeneration of deep brain nerves from multiple dimensions such as movement, safety, and preparation.
[0014] A method for preparing a micro-peristaltic device for targeted regeneration of deep brain nerves, characterized by comprising the following steps:
[0015] S1. Preparation of biomimetic peristaltic shell: Select one of polyethylene glycol diacrylate, polydimethicone, silk fibroin or gelatin-methacrylamide hydrogel as the shell material, and form it by micro-nano 3D printing process, and process a continuous ring-shaped fold structure on the surface of the shell.
[0016] S2. Assemble the drive unit: Select shape memory alloy wire or hydrogel as the drive material and fix it inside the biomimetic peristaltic shell to ensure that the material can contract under electric current stimulation and recover its deformation when the power is cut off.
[0017] S3. By sending current signals and control commands through an external control platform, the peristaltic motion performance, positioning accuracy, and sensor data transmission stability of the micro-peristaltic are tested to ensure that the application requirements for targeted regeneration of deep brain nerves are met.
[0018] In summary, the technical effects and advantages of this invention are as follows:
[0019] 1. In this invention, the micro-peristaltic is worm-shaped and consists of two C-shaped structures. Combined with the continuous annular fold structure on the surface, it can simulate the efficient peristaltic mode of organisms in narrow spaces. It can adapt to the complex lumen and tissue gaps in the deep brain nerve region, and avoid scratching damage to the surrounding soft tissues during peristalsis. At the same time, the fold structure provides stable waveform power for movement, ensuring flexible movement in the delicate neural environment.
[0020] 2. In this invention, shape memory alloy wire is used as the driving structure. Its contraction and recovery deformation when the power is cut off are precisely controlled by current, which gets rid of the disadvantage of traditional magnetic drive being easily affected by external environmental interference. Even in the complex biomagnetic field environment in the body, it can still achieve stable peristalsis. Moreover, the shape memory alloy wire is wrapped with a polyimide insulating coating, which can avoid electrical interference with internal components, further ensuring driving stability and ensuring accurate arrival at the target area of deep brain nerves.
[0021] 3. In this invention, the outer shell is made of biocompatible and biodegradable materials such as polyethylene glycol diacrylate, silk fibroin or gelatin-methacrylamide hydrogel. After use, it can be gradually degraded by the body's natural metabolism, without the need for a second surgery to remove it. This completely avoids the risks of inflammation, rejection and other problems that may be caused by the long-term retention of traditional non-degradable devices in the body, and is especially suitable for the application needs of sensitive tissue areas such as deep brain nerves.
[0022] 4. In this invention, the biomimetic peristaltic shell is formed by a mature micro-nano 3D printing process, which can accurately process the preset wrinkled structure and C-shaped main body shape, with high preparation efficiency and controllable size. After assembly, the core parameters such as peristaltic performance and positioning accuracy can be tested through an in vitro control platform, without the need for complicated in vivo debugging process, reducing the difficulty of research and development and production, and making it easier to transform into clinical applications.
[0023] 5. In this invention, in addition to the core functional components, the lubricating coating sprayed on the outer shell surface can further reduce the coefficient of friction with biological tissues and reduce movement resistance; the hollow channel reserved inside can accommodate wires or transmit physiological saline, providing auxiliary support for the stability of the components. The overall design ensures the applicability and reliability of the micro-peristaltic device in the scenario of targeted regeneration of deep brain nerves from multiple dimensions such as movement, safety and preparation. Attached Figure Description
[0024] Figure 1 This is a schematic diagram of the overall structure of a micro-peristaltic device for targeted regeneration of deep brain nerves according to the present invention;
[0025] Figure 2 This is a schematic flowchart of a method for preparing a micro-peristaltic device for targeted regeneration of deep brain nerves according to the present invention.
[0026] In the image: 1. Shape memory alloy wire; 2. Micro-peristaltic; 3. Wrinkled structure. Detailed Implementation
[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0028] refer to Figures 1-2 The micro-peristaltic device 2 shown is for targeted regeneration of deep brain nerves. It includes a micro-peristaltic device 2 with a pleated structure 3 on its surface and a drive structure inside. The micro-peristaltic device 2 is worm-shaped and consists of two C-shaped structures. With the continuous annular pleated structure 3 on its surface, it can simulate the efficient peristaltic movement of organisms in narrow spaces. It can adapt to the complex lumen and tissue gaps in deep brain nerve regions and avoid scratching damage to surrounding soft tissues during peristalsis. At the same time, the pleated structure 3 provides stable waveform power for movement, ensuring flexible movement in the delicate neural environment.
[0029] Furthermore, the driving structure is a shape memory alloy wire 1. By using shape memory alloy wire 1 as the driving structure, its contraction and deformation recovery when power is cut off are precisely controlled by current, which gets rid of the disadvantage of traditional magnetic drive being easily affected by external environmental interference. Even in the complex biomagnetic field environment in the body, it can still achieve stable peristalsis. Moreover, the shape memory alloy wire 1 is wrapped with a polyimide insulating coating, which can avoid electrical interference with internal components, further ensuring driving stability and ensuring accurate arrival at the target area of deep brain nerves.
[0030] Furthermore, by controlling the shape memory alloy wire 1 with current, the wire can be contracted and deformed upon power failure, thereby driving the micro-peristaltic device 2 to generate peristaltic motion.
[0031] Furthermore, the outer shell of the micro-peristaltic device 2 is made of a biocompatible and biodegradable material, specifically one of polyethylene glycol diacrylate, silk fibroin, or gelatin-methacrylamide hydrogel. After use, it can be naturally degraded through biological metabolism, avoiding the risk of long-term retention in the body. The outer shell is made of biocompatible and biodegradable materials such as polyethylene glycol diacrylate, silk fibroin, or gelatin-methacrylamide hydrogel. After use, it can be gradually degraded through the body's natural metabolism, without the need for secondary surgery to remove it. This completely avoids the risks of inflammation, rejection, etc. that may be caused by the long-term retention of traditional non-degradable devices in the body, and is especially suitable for the application needs of sensitive tissue areas such as deep brain nerves.
[0032] Furthermore, the micro-peristaltic 2 has an overall worm-like structure, composed of two C-shaped structures.
[0033] Furthermore, the edges of the wrinkled structure 3 on the surface of the micro-peristaltic 2 shell are rounded with a radius of 2-5μm to avoid scratching damage to the soft tissues around the brain nerves during peristalsis. The biomimetic peristaltic shell is formed by mature micro-nano 3D printing technology, which can accurately process the preset wrinkled structure 3 and C-shaped main body shape, with high preparation efficiency and controllable size. After assembly, the core parameters such as peristaltic performance and positioning accuracy can be tested through an in vitro control platform, without the need for complicated in vivo debugging procedures, reducing the difficulty of research and development and production, and making it easier to translate into clinical applications.
[0034] Furthermore, the shape memory alloy wire 1 is wrapped with an insulating coating made of polyimide. In addition to the core functional components, the lubricating coating sprayed on the outer shell can further reduce the coefficient of friction with biological tissues and reduce movement resistance. The hollow channel reserved inside can accommodate wires or transmit saline solution, providing auxiliary support for the stability of the component. The overall design ensures the applicability and reliability of the micro-peristaltic device 2 in the deep brain nerve directional regeneration scenario from multiple dimensions such as movement, safety, and preparation.
[0035] A method for preparing a miniature peristaltic device 2 for targeted regeneration of deep brain nerves, characterized by comprising the following steps:
[0036] S1. Preparation of biomimetic peristaltic shell: Select one of polyethylene glycol diacrylate, polydimethicone, silk fibroin or gelatin-methacrylamide hydrogel as the shell material, and form it by micro-nano 3D printing process, and process a continuous ring-shaped fold structure on the surface of the shell.
[0037] S2. Assemble the driving unit: Select shape memory alloy wire 1 or hydrogel as the driving material and fix it inside the biomimetic peristaltic shell to ensure that the material can shrink under current stimulation and recover its deformation when the power is cut off.
[0038] S3. By sending current signals and control commands through the external control platform, the peristaltic motion performance, positioning accuracy and sensor data transmission stability of the micro-peristaltic device 2 are tested to ensure that the application requirements for targeted regeneration of deep brain nerves are met.
[0039] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.
Claims
1. A micro-peristaltic device (2) for targeted regeneration of deep brain nerves, comprising a micro-peristaltic device (2), characterized in that: The surface of the micro-peristaltic (2) is provided with a pleated structure (3), and the interior of the micro-peristaltic (2) is provided with a driving structure.
2. The micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1, characterized in that: The driving structure is a shape memory alloy wire (1).
3. The micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1, characterized in that: By controlling the shape memory alloy wire (1) with current, the wire can be contracted and restored to its original shape when the power is cut off, thereby driving the micro-peristaltic device (2) to generate peristaltic motion.
4. The micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1 and its preparation method, characterized in that: The outer shell of the micro-peristaltic (2) is made of a biocompatible and biodegradable material, specifically one of polyethylene glycol diacrylate, silk fibroin or gelatin-methacrylamide hydrogel. After use, it can be naturally degraded through biological metabolism, avoiding the risk of long-term retention in the body.
5. A micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1, characterized in that: The micro-peristaltic (2) has an overall worm-like structure and is composed of two C-shaped structures.
6. The micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1, characterized in that: The edges of the wrinkled structure (3) on the outer shell of the micro-peristaltic (2) are rounded with a radius of 2-5 μm to avoid scratching damage to the soft tissues around the brain nerves during peristalsis.
7. A micro-peristaltic device (2) for targeted regeneration of deep brain nerves according to claim 1, characterized in that: The shape memory alloy wire (1) is wrapped with an insulating coating, the coating material being polyimide.
8. A method for preparing a micro-peristaltic device (2) for targeted regeneration of deep brain nerves, characterized in that, Includes the following steps: S1. Preparation of biomimetic peristaltic shell: Select one of polyethylene glycol diacrylate, polydimethicone, silk fibroin or gelatin-methacrylamide hydrogel as shell material, form it by micro-nano 3D printing process, and process a continuous ring-shaped fold structure on the shell surface (3). S2. Assemble the driving unit: Select memory alloy wire (1) or hydrogel as the driving material and fix it inside the biomimetic peristaltic shell to ensure that the material can shrink and recover its deformation when the current is turned off. S3. By sending current signals and control commands through the external control platform, test the peristaltic motion performance, positioning accuracy and sensor data transmission stability of the micro-peristaltic device (2) to ensure that it meets the application requirements of deep brain nerve directional regeneration.