Antipruritic composition containing mussel mucin and preparation method of antipruritic composition

Abstract

The invention discloses an antipruritic composition containing mussel mucin and a preparation method of the antipruritic composition. The mussel mucin not only can effectively relieve skin itch, but also can promote repair and regeneration of damaged skin and improve the overall state of the skin; the natural plant essential oil is introduced, so that the itching relieving effect is further enhanced, meanwhile, the product is endowed with soothing and antibacterial characteristics, and the use experience is improved; the reasonable addition of the humectant ensures that the skin is kept moist in the itching relieving process, and secondary stimulation caused by dryness is avoided, so that the mildness and applicability of the product are improved; by selecting the stabilizer and the emulsifier, the stability and uniformity of the composition in the storage and use processes are ensured, and the problem that the traditional natural extract is easy to inactivate is solved; and the preservative is selected, so that the requirements of safety and shelf life are met, and the product can still keep excellent performance in long-term storage.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to an antipruritic composition containing mussel adhesive protein and its preparation method. Background Technology

[0002] Mussel adhesive protein possesses skin-repairing, anti-inflammatory, antioxidant, moisturizing, and wound-healing properties. It contains a large number of dopa groups, which can bind to skin surface cells, promoting cell proliferation and differentiation, thus helping to repair damaged skin tissue and improve problems such as roughness and chapping. It can also inhibit the release of inflammatory factors, reducing skin inflammation. For some skin inflammations such as allergic dermatitis and acne, mussel adhesive protein can reduce redness, swelling, and itching at the inflamed site, soothing the skin.

[0003] Existing antipruritic compositions suffer from problems such as limited effectiveness, short duration of action, or significant side effects. Traditional antipruritic drugs may only target a specific symptom, such as relieving itching by inhibiting histamine release, but cannot comprehensively improve the overall condition of the skin. In addition, long-term use of some chemical components may damage the skin barrier, or even induce drug resistance or allergic reactions. While some natural extracts are relatively mild, their active ingredients have poor stability and are prone to losing activity during storage and use, thus affecting the actual therapeutic effect. Therefore, this invention provides an antipruritic composition containing mussel adhesive protein and its preparation method. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides an antipruritic composition containing mussel adhesive protein and its preparation method, thereby solving the aforementioned problems.

[0005] To achieve the above objectives, the present invention provides the following technical solution: an antipruritic composition containing mussel adhesive protein, wherein the composition comprises the following raw materials in parts by weight:

[0006] Mussel adhesive protein extract, 10%–30%, is used to ensure both antipruritic effect and skin repair.

[0007] Natural plant essential oils, 5%–15%, are used to enhance the overall antipruritic effect of the composition;

[0008] Moisturizer, 8%–20%, is used to maintain the skin's moisture balance and prevent secondary irritation caused by dryness;

[0009] Stabilizer, 1% to 5%, is used to ensure the stability of the active ingredient in the composition during storage;

[0010] Emulsifier, 2% to 6%, to ensure uniform mixing of the oil and water phases in the composition without causing irritation;

[0011] Preservatives, 1% to 2%, are used to extend the shelf life of products while ensuring safety.

[0012] Deionized water, in the remainder, is used as a solvent to reduce the impact of impurities on the composition's properties and improve the overall purity of the formulation.

[0013] Preferably, the natural plant essential oil is selected from one or more of lavender essential oil, tea tree essential oil, or chamomile essential oil.

[0014] Preferably, the moisturizer is sodium hyaluronate or glycerin.

[0015] Preferably, the stabilizer is a food-grade antioxidant.

[0016] Preferably, the preservative is phenoxyethanol or potassium sorbate.

[0017] A method for preparing an antipruritic composition containing mussel adhesive protein includes the following steps:

[0018] S1. Heat deionized water to 70℃~80℃, and add stabilizer and emulsifier in sequence under stirring. Dissolve and mix thoroughly to obtain premix A.

[0019] S2. Mix mussel adhesive protein extract with humectant and stir at 40℃~50℃ until completely dissolved to form premix B;

[0020] S3. Slowly add premixed solution B to premixed solution A while maintaining a constant temperature and stirring to ensure that all components are fully mixed to form a uniform mixture C.

[0021] S4. Slowly add the natural plant essential oil to the mixture C, and continue stirring for 10-20 minutes to ensure the uniform distribution of the essential oil in the system;

[0022] S5. After the mixture has cooled to room temperature, add the preservative and homogenize it using a homogenizer to achieve a fine and stable texture.

[0023] S6. Filter the final mixture through a microporous filter to remove impurities or undissolved particles, thereby improving the purity and safety of the product.

[0024] S7. Fill the filtered composition into sterile containers and seal them under sterile conditions to complete the preparation process and ensure the quality stability of the product during storage and transportation.

[0025] Beneficial effects

[0026] Compared with the prior art, the present invention has the following advantages:

[0027] This invention scientifically combines mussel adhesive protein extract with other functional ingredients, fully leveraging the synergistic effects of each component. Mussel adhesive protein not only effectively relieves skin itching but also promotes the repair and regeneration of damaged skin, improving its overall condition. The introduction of natural plant essential oils further enhances the anti-itch effect, while also imparting soothing and antibacterial properties, improving the user experience. The appropriate addition of moisturizers ensures that the skin remains hydrated during the itch relief process, avoiding secondary irritation caused by dryness, thus improving the product's gentleness and applicability. The selection of stabilizers and emulsifiers ensures the stability and uniformity of the composition during storage and use, solving the problem of easy deactivation of traditional natural extracts. The selection of preservatives balances safety and shelf-life requirements, allowing the product to maintain excellent performance during long-term storage. The overall formula design is scientifically sound, overcoming the shortcomings of existing technologies such as single-effect, short-lasting, or significant side effects, while achieving a unified multi-functional approach, providing users with an efficient, safe, and gentle anti-itch solution. Attached Figure Description

[0028] Figure 1 This is a flowchart of the preparation process of the present invention. Detailed Implementation

[0029] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0030] Please see Figure 1 An antipruritic composition containing mussel adhesive protein and its preparation method, wherein the composition comprises the following raw materials in parts by weight:

[0031] Mussel adhesive protein extract, 10%–30%, is a core ingredient rich in various amino acids and active factors. It can relieve itching while promoting the regeneration of epidermal cells and accelerating the healing process of damaged skin. The unique biocompatibility of mussel adhesive protein extract ensures that the product will not cause allergic reactions during use and is suitable for long-term use.

[0032] Natural plant essential oils, 5%–15%, not only enhance the product’s antipruritic properties but also give the composition a fragrance, ensuring that its ingredients are gentle and non-irritating to the skin. They also have certain antibacterial and anti-inflammatory properties, further enhancing the product’s overall efficacy.

[0033] Moisturizer, 8%–20%. The addition of moisturizer can prevent skin dryness caused by anti-itch treatment. It can provide long-lasting moisturizing effect to the skin without interfering with the function of other active ingredients and avoid secondary irritation caused by dryness.

[0034] Stabilizer, 1% to 5%. The addition of stabilizer can extend the shelf life of the product and ensure the stability of each component during storage. It can also effectively prevent the product performance from declining due to environmental changes or the passage of time, and ensure the reliability and consistency of the composition under different conditions.

[0035] Emulsifier, 2% to 6%. The addition of emulsifier allows the oil and water phases to fully blend, forming a delicate emulsion texture that is easy to apply and absorbs quickly, avoiding the stickiness that may result from traditional formulas.

[0036] Preservatives, 1% to 2%, can effectively inhibit the growth of microorganisms, ensuring that the product can maintain a good hygienic condition after opening, and extending the product's shelf life while ensuring safety.

[0037] Deionized water, remaining amount. Deionized water is used as a solvent. The addition of deionized water can reduce the impact of impurities on the performance of the composition and improve the purity of the overall formulation.

[0038] The rational combination of mussel adhesive protein extract, natural plant essential oils, moisturizers, stabilizers, emulsifiers, preservatives and deionized water ensures that the resulting antipruritic composition not only has excellent antipruritic effects, but also takes into account skin repair, moisturizing and long-term safety.

[0039] Specifically, the natural plant essential oils are selected from one or more of lavender, tea tree, or chamomile essential oils. Lavender essential oil has a soothing effect on the skin, effectively relieving discomfort caused by itching; tea tree essential oil has antibacterial and anti-inflammatory properties, improving the skin's microenvironment and reducing the risk of infection; chamomile essential oil has gentle repairing properties, making it suitable for sensitive skin. The combination of lavender, tea tree, or chamomile essential oils not only effectively enhances the antipruritic effect of the composition but also significantly improves user comfort.

[0040] Specifically, the moisturizer chosen is sodium hyaluronate or glycerin. Sodium hyaluronate has excellent moisturizing effects and can form a protective film on the skin surface to effectively lock in moisture and prevent water loss. Glycerin has excellent hygroscopic effects and can absorb moisture from the air to provide additional moisturizing effects. The choice of sodium hyaluronate or glycerin not only ensures that the composition can maintain the skin's hydration while relieving itching, but also further enhances the product's gentleness and applicability, making it suitable for various skin types.

[0041] Specifically, the stabilizer selected is a food-grade antioxidant. Food-grade antioxidants not only meet safety standards, but also reduce skin irritation during use, further improving the product's gentleness and reliability. In addition, food-grade antioxidants have the ability to extend the product's shelf life and can effectively prevent the active ingredients from undergoing oxidation reactions during storage, ensuring the product's efficacy remains stable.

[0042] Specifically, phenoxyethanol or potassium sorbate are selected as preservatives. Phenoxyethanol has mild antibacterial properties, effectively inhibiting microbial growth and extending product shelf life while ensuring product safety. Potassium sorbate has low irritation and high preservative capacity, making it suitable for sensitive skin and ensuring the product maintains good hygiene after opening. The choice of phenoxyethanol or potassium sorbate not only meets the product's preservative requirements but also further enhances the safety and suitability of the composition, making it more suitable for long-term use.

[0043] The mussel adhesive protein in the above-mentioned raw materials can not only effectively relieve skin itching, but also promote the repair and regeneration of damaged skin and improve the overall condition of the skin. The introduction of natural plant essential oils further enhances the anti-itch effect, while giving the product soothing and antibacterial properties, improving the user experience. The reasonable addition of moisturizers ensures that the skin remains moisturized during the anti-itch process, avoiding secondary irritation caused by dryness, thereby improving the product's gentleness and applicability. The selection of stabilizers and emulsifiers ensures the stability and uniformity of the composition during storage and use, solving the problem of easy inactivation of traditional natural extracts. In addition, the selection of preservatives takes into account both safety and shelf-life requirements, enabling the product to maintain excellent performance during long-term storage.

[0044] A method for preparing an antipruritic composition containing mussel adhesive protein includes the following steps:

[0045] S1. Heat deionized water to 70℃~80℃, and add stabilizer and emulsifier in sequence under stirring. Dissolve and mix thoroughly to obtain premix A.

[0046] S2. Mix mussel adhesive protein extract with humectant and stir at 40℃~50℃ until completely dissolved to form premix B;

[0047] S3. Slowly add premixed solution B to premixed solution A while maintaining a constant temperature and stirring to ensure that all components are fully mixed to form a uniform mixture C.

[0048] S4. Slowly add the natural plant essential oil to the mixture C, and continue stirring for 10-20 minutes to ensure the uniform distribution of the essential oil in the system;

[0049] S5. After the mixture has cooled to room temperature, add the preservative and homogenize it using a homogenizer to achieve a fine and stable texture.

[0050] S6. Filter the final mixture through a microporous filter to remove impurities or undissolved particles, thereby improving the purity and safety of the product.

[0051] S7. Fill the filtered composition into sterile containers and seal them under sterile conditions to complete the preparation process and ensure the quality stability of the product during storage and transportation.

[0052] The above methods and steps effectively improve the stability and efficacy of the antipruritic composition. By precisely controlling the temperature and stirring conditions at each step, the compatibility between the components is ensured to reach its optimal state. The use of a microporous filtration device not only removes impurities but also further optimizes the product's fineness, making it easier for the skin to absorb. Aseptic filling and sealing operations ensure product safety and avoid the risk of external contamination. Therefore, while ensuring highly effective antipruritic function, the user experience is also taken into account, making the product more in line with consumer needs.

[0053] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0054] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0055] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An antipruritic composition containing mussel adhesive protein, characterized in that, The composition comprises the following raw materials in parts by weight: Mussel adhesive protein extract, 10%–30%, is used to ensure both antipruritic effect and skin repair. Natural plant essential oils, 5%–15%, are used to enhance the overall antipruritic effect of the composition; Moisturizer, 8%–20%, is used to maintain the skin's moisture balance and prevent secondary irritation caused by dryness; Stabilizer, 1% to 5%, is used to ensure the stability of the active ingredient in the composition during storage; Emulsifier, 2% to 6%, to ensure uniform mixing of the oil and water phases in the composition without causing irritation; Preservatives, 1% to 2%, are used to extend the shelf life of products while ensuring safety. Deionized water, in the remainder, is used as a solvent to reduce the impact of impurities on the composition's properties and improve the overall purity of the formulation.

2. The antipruritic composition containing mussel adhesive protein according to claim 1, characterized in that, The natural plant essential oil is selected from one or more of lavender essential oil, tea tree essential oil, or chamomile essential oil.

3. The antipruritic composition containing mussel adhesive protein according to claim 1, characterized in that, The moisturizer is selected from sodium hyaluronate or glycerin.

4. The antipruritic composition containing mussel adhesive protein according to claim 1, characterized in that, The stabilizer is a food-grade antioxidant.

5. The antipruritic composition containing mussel adhesive protein according to claim 1, characterized in that, The emulsifier is selected from polysorbates or sucrose esters.

6. The antipruritic composition containing mussel adhesive protein according to claim 1, characterized in that, The preservative is selected from phenoxyethanol or potassium sorbate.

7. A method for preparing an antipruritic composition containing mussel adhesive protein as described in any one of claims 1-6, characterized in that, Includes the following steps: S1. Heat deionized water to 70℃~80℃, and add stabilizer and emulsifier in sequence under stirring. Dissolve and mix thoroughly to obtain premix A. S2. Mix mussel adhesive protein extract with humectant and stir at 40℃~50℃ until completely dissolved to form premix B; S3. Slowly add premixed solution B to premixed solution A while maintaining a constant temperature and stirring to ensure that all components are fully mixed to form a uniform mixture C. S4. Slowly add the natural plant essential oil to the mixture C, and continue stirring for 10-20 minutes to ensure the uniform distribution of the essential oil in the system; S5. After the mixture has cooled to room temperature, add the preservative and homogenize it using a homogenizer to achieve a fine and stable texture. S6. Filter the final mixture through a microporous filter to remove impurities or undissolved particles, thereby improving the purity and safety of the product. S7. Fill the filtered composition into sterile containers and seal them under sterile conditions to complete the preparation process and ensure the quality stability of the product during storage and transportation.

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