Preparation method and application of flos magnoliae extract for lip care

Abstract

The invention discloses a preparation method of a flos magnoliae extract for lip care, and belongs to the technical field of biological extraction, and the preparation method comprises the following steps: (1) crushing flos magnoliae to obtain flos magnoliae powder for later use; (2) mixing caprylic / capric triglyceride and isononyl isononanoate to obtain a composite solvent for later use; (3) mixing the flos magnoliae powder with a composite solvent, feeding the mixture into a micro-jet extractor, and discharging to obtain a primary extracting solution for later use; and (4) performing centrifugal separation on the primary extracting solution, and performing membrane filtration to obtain the flos magnoliae extract. The magnolia biondii extract prepared by the invention can simultaneously have the effects of relieving, repairing ultraviolet injury, promoting angiogenesis and promoting collagen regeneration activity, can meet various requirements of daily lip care, can relieve inflammation problems caused by ultraviolet injury and promote angiogenesis while meeting basic lip moisturizing and relieving requirements, and has the effects of preventing and treating inflammation, reducing inflammation and the like. Collagen and elastic fibers are stimulated to regenerate, so that the lips are ruddy and full.

Description

Technical Field

[0001] This invention belongs to the field of bio-extraction technology, specifically relating to a method for preparing and applying a Magnolia officinalis extract for lip care. Background Technology

[0002] Although the skin on the lips, like the skin on other parts of the face, is composed of the epidermis, dermis, and subcutaneous tissue, the thickness of the facial epidermis (0.8 mm) is eight times that of the lip epidermis (0.06 mm). Furthermore, the skin on the lips lacks sebaceous glands and does not secrete oil, making it more susceptible to environmental disturbances, ultimately manifesting as dryness, peeling, and cheilitis. Simultaneously, long-term dryness, peeling, cheilitis, UV damage, and age-related collagen loss can all lead to darkening of the lips and increased and deepened lip lines. Therefore, to fundamentally improve lip darkening and texture, it is necessary not only to achieve basic moisturizing and soothing effects but also to possess certain UV damage repair and collagen regeneration-promoting activities. However, current lip care ingredients cannot effectively combine these needs, requiring a combination of multiple ingredients to achieve the desired effects. Specifically, in terms of moisturizing and soothing, lip products often use a blend of plant oils. However, low-concentration plant oils cannot effectively exert their effects, while high-concentration plant oils result in a sticky and heavy feel on the lips, leading to a poor skin experience. For repairing UV damage, soothing ingredients are often used instead, with few ingredients specifically designed for UV damage repair. In promoting collagen regeneration, peptide compounds are mainly used, which are expensive and require demanding storage conditions. In summary, current single-ingredient lip care products cannot simultaneously possess soothing, UV damage repair, and collagen regeneration-promoting activities to effectively improve lip dullness and reduce lip lines. Multiple ingredient blends are needed, but the delicate and sensitive skin on the lips increases the risk of allergies and safety concerns when multiple ingredients are combined. Therefore, there is an urgent need to develop a green and natural ingredient with multiple functions, including moisturizing, soothing, UV damage repair, and collagen regeneration promotion, to improve lip dullness and reduce lip lines.

[0003] Magnolia denudata, also known as Magnolia, has dried flower buds called Xin Yi in the pharmacopoeia. It contains abundant magnolia resins and volatile oils, and is commonly used for nasal congestion relief and headaches caused by wind-cold. Currently, it is frequently used in cosmetics as a soothing ingredient for post-sun exposure repair, daily relief, and delaying inflammatory aging, but it has not been applied to lip care. For example, the application of Magnolia denudata extract disclosed in patent publication number CN117379348A in the preparation of cosmetics that inhibit inflammatory aging of the skin shows that Magnolia denudata extract can inhibit the expression of matrix metalloproteinases and β-galactosidase by inhibiting chemokine CXCL10-induced cellular inflammatory aging, thereby delaying skin aging. However, it does not demonstrate its ability to promote collagen production. Furthermore, in lip care, the appearance of lip lines is not solely due to inflammatory aging, but rather the result of multiple factors working together. Patent publication number CN115948480A discloses a Magnolia officinalis fermented liquid with antioxidant, anti-inflammatory, and brightening effects, along with its preparation method and application. This indicates that the fermented Magnolia officinalis extract can improve dull skin, rough skin, and skin sensitivity through antioxidant, anti-inflammatory, and brightening effects. However, since this fermented liquid is a water-soluble product, and lip products are mostly wax-based or oil-based, it is not suitable. Furthermore, in the preparation of Magnolia officinalis extract, besides fermentation, the active ingredients such as magnolol and volatile oils are fat-soluble. Therefore, current preparation processes often employ organic solvent extraction. For example, patent publication number CN114557933A discloses a Magnolia officinalis flower extract, its preparation method, and application, which uses repeated ethanol extraction for enrichment and pH adjustment with citric acid and triethylamine. The residue of organic solvents such as ethanol and the irritation of acidic reagents can pose potential irritation to lip care products. Therefore, to develop a Magnolia officinalis extract suitable for lip care, a gentle and non-irritating extraction method must be chosen. Summary of the Invention

[0004] The purpose of this invention is to provide a method for preparing a Magnolia officinalis extract for lip care.

[0005] A method for preparing a Magnolia officinalis extract for lip care includes the following steps: (1) Grind the magnolia flowers into powder for later use; (2) Mix octanoic acid / capric acid triglyceride and isononyl isononanoate to obtain a composite solvent for later use; (3) Mix the Magnolia officinalis powder with the composite solvent and feed it into the microfluidic extractor. After discharge, the initial extract is prepared for use. (4) The initial extract was centrifuged and then filtered through a membrane to obtain the extract of Magnolia officinalis.

[0006] Furthermore, the mass ratio of caprylic / capric triglyceride and isononyl isononanoate when mixed in step (2) is 7:3-2:3.

[0007] Furthermore, in step (3), the mass ratio of the Magnolia officinalis powder to the composite solvent is 1:3-1:10.

[0008] Furthermore, the feeding rate in step (3) is 10-30 L / min.

[0009] Furthermore, the temperature of the microjet extractor described in step (3) is controlled at 20-30℃.

[0010] Furthermore, in step (3), the microjet extractor controls the pore size to be 500-800 μm, the rotation speed to be 500-1000 rpm, and the continuous stirring time to be 60-120 min.

[0011] Furthermore, in step (4), the centrifugation speed is controlled at 4000-10000 rpm and the centrifugation time is controlled at 30-60 min.

[0012] Furthermore, the membrane filtration described in step (4) specifically involves sequentially using a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm for filtration.

[0013] An application of a Magnolia officinalis extract for lip care, used as an additive in cosmetics.

[0014] Caprylic / capric triglycerides, a plant derivative derived from palm or coconut oil, are commonly used plant extraction solvents in the cosmetics and food industries. They possess high stability and biocompatibility, exhibiting excellent solubility for lipophilic or weakly polar components such as flavonoids and terpenes. They form strong hydrogen bonds or dipole interactions with active ingredients, significantly improving extraction efficiency and stability within the system, making them an excellent alternative to organic solvent extraction. Caprylic / capric triglycerides also have strong moisturizing properties, forming a complete oil film on the lip surface to lock in moisture. However, despite their lighter texture compared to plant and mineral oils, they still feel relatively heavy in lip care products. Isonononyl isononanoate, a light oil, not only possesses excellent dispersibility and skin affinity, forming a thin protective film on the skin surface to reduce moisture loss from the lips, but also addresses the heaviness issue of plant and mineral oils. Furthermore, it has excellent system compatibility and is a classic base component in lip care and makeup products. Therefore, combining caprylic / capric triglyceride and isononyl isononanoate as an extraction solvent for lipid-soluble components such as magnolin in Magnolia officinalis not only ensures the extraction efficiency of active ingredients and the physiological activity of Magnolia officinalis extract, but also provides the prepared Magnolia officinalis extract with good compatibility in lip care systems and lip makeup, solving the problem of greasiness and heaviness of oil-based products and improving the spreadability of the raw material.

[0015] The beneficial effects of this invention are: The extract of Magnolia officinalis prepared in this invention can simultaneously soothe, repair UV damage, promote angiogenesis, and promote collagen regeneration. It can meet various daily lip care needs, satisfying basic lip moisturizing and soothing needs while alleviating inflammation caused by UV damage, promoting angiogenesis, stimulating collagen and elastin fiber regeneration, filling in dry lines and fine lines, brightening lip color, and reducing lip lines, making lips more rosy and full. Attached Figure Description

[0016] Figure 1 This is an experimental record diagram of the angiogenesis promotion test corresponding to Test Example 4 of the present invention; Figure 2 This is an experimental record diagram of the lip test corresponding to Test Example 6 of the present invention. Detailed Implementation

[0017] The specific embodiments of the present invention will be further described in detail with reference to the accompanying drawings, examples, and comparative examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the invention.

[0018] Example 1 A method for preparing a Magnolia officinalis extract for lip care: (1) Crush the magnolia flowers; (2) Mix caprylic acid / capric acid triglyceride and isononyl isononanoate at a mass ratio of 7:3 to obtain a composite solvent. Add the Magnolia officinalis powder and the composite solvent at a material-liquid ratio of 1:10. Add the material to a microfluidic extractor at a temperature of 25℃ at a feeding rate of 25L / min. The micropore diameter of the extractor is 600μm, the rotation speed is 6000rpm, and the stirring is continued for 60min. Then, the material is discharged to obtain the initial extract. (3) The initial extract of Magnolia officinalis was centrifuged at 4000 rpm for 30 min to obtain the separation liquid. Then, it was filtered through a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm to obtain the extract of Magnolia officinalis.

[0019] Example 2 A method for preparing a Magnolia officinalis extract for lip care: (1) Crush the magnolia flowers; (2) Mix caprylic acid / capric acid triglyceride and isononyl isononanoate in a mass ratio of 2:3 to obtain a composite solvent. Add the Magnolia officinalis powder and the composite solvent in a material-liquid ratio of 1:3. Add the material to a microfluidic extractor at a temperature of 25℃ at a feeding rate of 25L / min. The micropore diameter of the extractor is 600μm, the rotation speed is 6000rpm, and the stirring is continued for 60min. Then, the material is discharged to obtain the initial extract. (3) The initial extract of Magnolia officinalis was centrifuged at 4000 rpm for 30 min to obtain the separation liquid. Then, it was filtered through a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm to obtain the extract of Magnolia officinalis.

[0020] Example 3 A method for preparing a Magnolia officinalis extract for lip care: (1) Crush the magnolia flowers; (2) Mix caprylic acid / capric acid triglyceride and isononyl isononanoate in a mass ratio of 3:2 to obtain a composite solvent. Add the Magnolia officinalis powder and the composite solvent in a material-liquid ratio of 1:5. Add the material to a microfluidic extractor at a temperature of 25℃ at a feeding rate of 25L / min. The micropore diameter of the extractor is 600μm, the rotation speed is 6000rpm, and the stirring is continued for 60min. Then, the material is discharged to obtain the initial extract. (3) The initial extract of Magnolia officinalis was centrifuged at 4000 rpm for 30 min to obtain the separation liquid. Then, it was filtered through a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm to obtain the extract of Magnolia officinalis.

[0021] Example 4 A method for preparing a Magnolia officinalis extract for lip care: (1) Crush the magnolia flowers; (2) Mix caprylic acid / capric acid triglyceride and isononyl isononanoate in a mass ratio of 1:1 to obtain a composite solvent. Add the Magnolia officinalis powder and the composite solvent in a material-liquid ratio of 1:6. Add the material to a microfluidic extractor at a temperature of 25℃ at a feeding rate of 25L / min. The micropore diameter of the extractor is 600μm, the rotation speed is 6000rpm, and the stirring is continued for 60min. Then, the material is discharged to obtain the initial extract. (3) The initial extract of Magnolia officinalis was centrifuged at 4000 rpm for 30 min to obtain the separation liquid. Then, it was filtered through a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm to obtain the extract of Magnolia officinalis.

[0022] Example 5 A method for preparing a Magnolia officinalis extract for lip care: (1) Crush the magnolia flowers; (2) Mix caprylic acid / capric acid triglyceride and isononyl isononanoate in a mass ratio of 2:3 to obtain a composite solvent. Add the Magnolia officinalis powder and the composite solvent in a material-liquid ratio of 1:8. Add the material to a microfluidic extractor at a temperature of 25℃ at a feeding rate of 25L / min. The micropore diameter of the extractor is 600μm, the rotation speed is 6000rpm, and the stirring is continued for 60min. Then, the material is discharged to obtain the initial extract. (3) The initial extract of Magnolia officinalis was centrifuged at 4000 rpm for 30 min to obtain the separation liquid. Then, it was filtered through a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm to obtain the extract of Magnolia officinalis.

[0023] Caprylic / capric triglyceride and isononyl isononanoate were used as a composite extraction solvent to extract Magnolia officinalis extract. This combination of oils forms a complete lip film on the lip surface, providing moisturizing effects. Simultaneously, the addition of caprylic / capric triglyceride ensures the extraction of fat-soluble components such as magnolin from Magnolia officinalis, preserving the physiological activity of the extract and avoiding residues from traditional organic solvents. The addition of isononyl isononanoate improves the skin-friendliness of the oil, reduces the stickiness and heaviness on the lips, and enhances the spreadability of the raw material. With the support of the integrated makeup and skincare concept, the Magnolia officinalis extract prepared in this invention can also be added as an active ingredient to lipsticks, foundations, and other makeup products.

[0024] Example 6 A lipstick containing Magnolia officinalis extract, specifically a lipstick containing the Magnolia officinalis extract of Example 3, the specific ingredients of which are shown in Table 1 below by weight percentage: Table 1 The preparation method of the lipstick formula with added Magnolia officinalis extract in this embodiment is as follows: 1) Heat phase A to 85-95℃, stir to dissolve, and dissolve evenly; 2) Cool down to 70-75℃, add phase B, stir well, hot fill, and cool.

[0025] Example 7 A lip gloss containing Magnolia officinalis extract, specifically a lip gloss containing the Magnolia officinalis extract of Example 3, the specific ingredients of which are shown in Table 2 below by weight percentage: Table 2

[0026] The preparation method of the lip gloss formula with added Magnolia officinalis extract in this embodiment is as follows: 1) Weigh phase A material into a container, heat to 85-75℃, and stir until completely homogeneous; 2) Cool down to 70-75℃, add phase B material, stir evenly, hot fill, and cool.

[0027] Example 8 A lipstick containing Magnolia officinalis extract, specifically a lipstick containing the Magnolia officinalis extract of Example 3, the specific ingredients of which are shown in Table 3 below by weight percentage: Table 3

[0028] The preparation method of the lipstick formula with added Magnolia officinalis extract in this embodiment is as follows: 1) Heat phase A to 85-95℃, stir to dissolve, and dissolve evenly; 2) Add phase B, stir well, and grind and disperse phase C in advance; 3) Add phase C, stir well, hot fill, and cool.

[0029] To verify the effectiveness of the present invention, the following effect experiment was conducted.

[0030] Test Example 1 Determination of magnolia lipid content: The extracts of *Magnolia denudata* prepared in each example were extracted and diluted in equal proportions with acetonitrile. Using magnolia lipid (HPLC ≥ 98%) as the standard reference, and acetonitrile and 0.2% phosphoric acid solution as the mobile phase, the magnolia lipid content was analyzed by HPLC. The specific results are shown in Table 4 below. Table 4 Group Magnolanin content (mg / ml) Example 1 6.25 Example 2 5.68 Example 3 6.02 Example 4 5.94 Example 5 5.83 As shown in Table 4, the composite solvent composed of caprylic / capric triglyceride and isononyl isononanoate can effectively extract magnolin from Magnolia officinalis, providing a more sustainable and greener extraction method for the extraction of fat-soluble components such as magnolin from Magnolia officinalis. This provides a safer raw material option for the application of Magnolia officinalis extract in cosmetic fields such as lip care, avoiding the potential risks of conventional organic solvent extraction.

[0031] Test Example 2 Soothing effect, neutrophil aggregation inhibition test: 1) Zebrafish selection: Healthy zebrafish embryos, 3 days post-fertilization, were selected and divided into a blank control group (C), a model control group (M), and a sample group (T). Twenty-four embryos were randomly selected from each group and transferred to a 3cm culture dish. 5mL of embryo culture medium was added, and the mixture was incubated at 28℃ for 2 hours. The sample group was prepared with 0.899g / L Magnolia officinalis extract as described in each example. 2) Copper sulfate modeling: Except for the blank control group, the culture medium of the other groups was replaced with fish embryo culture medium containing 10 μM copper sulfate and incubated at 28°C for 2 h; 3) Tissue fixation: Take out 24 juvenile fish from each group and put them into 2ml tubes. Take out the solution and add 0.5mL of 4% PFA within 10min. Fix the embryos at room temperature for 1h. 4) Embryo staining: Wash PFA with PBST and 50% ethanol, then add 0.5 mL of Sudan Black staining working solution, incubate at room temperature for 1 h, remove the staining solution, wash the embryo with 70% ethanol, PBST and bleach in sequence, add 0.5 mL of 50% glycerol PBS buffer, and incubate at room temperature for 1 h. 5) Observation and Counting: The tail of the fish embryo was photographed under a stereomicroscope, and the number of neutrophils in the three-quarters of the tail lateral line region from the anus of each fish embryo was counted. The neutrophil aggregation inhibition rate was calculated using the following formula: Inhibition rate = (MT) / (MC) × 100%; the specific results are shown in Table 5 below: Table 5

[0032] Test Example 3 UV damage repair efficacy test: 1) Zebrafish selection: Healthy zebrafish 2 days after fertilization were selected. A blank control group, a model control group, and a test substance group were set up. 24 zebrafish were randomly selected from each group and transferred to a 6-well plate. 6 mL of fish embryo culture medium was added and the plates were placed in a constant temperature incubator at 28±1℃ for 4±0.5 h. The sample group was set with 0.899 g / L Magnolia officinalis extract as in each example, and the positive control group was ceramide working solution. 2) Photodamage model establishment: After removing the blank control group, the remaining groups were cleaned with embryo buffer, dried, and 6 ml of embryo buffer was added. They were then placed in a UV irradiation chamber and irradiated for 2.5 h. Embryo buffer was added every hour to prevent water evaporation and abnormal death. 3) Staining: After irradiation, blot dry, add 0.02 mg / mL gentian violet working solution and stain for 20 min, then wash.

[0033] 4) Fluorescence observation: Zebrafish were anesthetized with tricaine and positioned on their sides. The fluorescent area of ​​the zebrafish was photographed under a fluorescence microscope using standardized parameters, and the photodamage inhibition rate was calculated. Photodamage inhibition rate = (fluorescent area of ​​model control group - fluorescent area of ​​test substance) / fluorescent area of ​​model control group; the specific results are shown in Table 6 below: Table 6

[0034] Test Example 4 Tests to promote angiogenesis: 1) Wild-type zebrafish embryos at 24 hpf were collected and divided into a blank control group (BC), a model control group (MC), a positive control group (PC), and a sample group, with 30 embryos in each group. 2 mL of embryo buffer was added to each well in the blank control group, 2 mL of modeling agent (2 μmol / L sorafenib) was added to each well in the model control group, and 2 mL of modeling agent mixed with sample or positive control was added to each well in the drug treatment group. All wells were incubated in a constant temperature incubator at (28±0.5 ℃) for 6 h. The sample group was prepared using 0.125 g / L Magnolia officinalis extract as described in each example, and the positive control group was prepared using asiaticoside working solution. 2) After incubation in a constant temperature incubator, change the drug solution. Add 2 mL of embryo buffer to each well of the blank control group, add 2 mL of embryo buffer to each well of the model control group, and add 2 mL of the corresponding concentration solution to each well of the drug treatment group. Incubate in a constant temperature incubator at (28±0.5 ℃) until the embryos develop to 72 hpf and then remove them. 3) Fix it onto methylcellulose and image it under an upright fluorescence microscope; 4) The length of intersegmental angiogenesis was statistically analyzed. The specific results are shown in Table 7 below: Table 7

[0035] Test Example 5 Tests to promote collagen regeneration: 1) Cell seeding: Seed the cell suspension into 96-well cell culture plates and incubate overnight; 2) Experimental Groups: The experiment included a blank control group (BC), a positive control group (PC), and a sample group. The sample group consisted of 0.025% Magnolia officinalis extract as described in each example, and each group had three replicate wells. 3) Drug administration: The blank control group was given only culture medium, the positive control group was given culture medium containing VC, and the sample group was given culture medium containing a certain concentration of the test substance. The incubation was carried out for 72 h. 4) Kit Testing: After incubation, cell supernatant was collected and stored at -80°C. Procollagen-1 levels were determined using an ELISA kit. Specific results are shown in Table 8 below. Table 8

[0036] According to the in vitro efficacy tests in Table 5, the Magnolia officinalis extract prepared in this invention has excellent soothing effects; especially the lips, as the sun-exposed area without the protection of sebaceous glands, are more susceptible to UV damage, and Magnolia officinalis extract has a good photodamage repair effect (Table 6); furthermore, angiogenesis is a key physiological basis for maintaining the rosy, full, and anti-dryness properties of the lips. Promoting angiogenesis can make the lips more sufficient in blood supply and more balanced in blood oxygenation, brightening the lip color from the source, improving the dullness and paleness of the lips, and the newly formed blood vessels can continuously deliver nutrients to the dermis of the lips, making the lip moisture circulation smoother, stimulating the regeneration of collagen and elastic fibers, filling in dry lines, fine lines and lightening lip lines, while test example 4 (Table 7) and the attached Figure 1 The results indicate that Magnolia officinalis extract promotes angiogenesis in zebrafish, suggesting that it should have the effect of brightening lip color and reducing lip lines in lip care, making lips more rosy and full. Furthermore, test example 5 (Table 8) shows that Magnolia officinalis extract can effectively promote the expression of Procollagen-1 collagen, having a certain firming and wrinkle-reducing effect on the lips. In summary, Magnolia officinalis extract has soothing, UV damage repair, and collagen expression-promoting activities, which can effectively relieve lip inflammation, brighten lip color, reduce dullness, and reduce lip lines, restoring lips to a "youthful" state, brightening lip color, reducing lip lines, and making lips more rosy and full.

[0037] Test Example 6 Evaluation of human lips: moisturizing, soothing, lip color, and lip lines: Ten subjects aged 18-30 years were selected. They applied the lip gloss (Example 7) once daily for two consecutive weeks. The lip gloss's moisturizing, soothing, brightening, and lip line-reducing effects were rated: 0-5 points for moderate effect, 5-7 points for effective effect, and 8-10 points for significant effect. Details are shown in Table 9 below. Table 9

[0038] Statistical analysis of the ratings from the 10 participants in Table 9 shows that the participants generally believed that the lip gloss containing Magnolia officinalis extract had certain moisturizing, soothing, lip color brightening, and lip line reduction effects. Among these, [the following information is missing from the original text]. Figure 2 The results after two weeks of use by one of the subjects showed that using the lip gloss containing Magnolia officinalis extract not only alleviated the subject's cheilitis but also brightened the lip color and reduced lip lines. In conclusion, the Magnolia officinalis extract provided by this invention not only meets basic daily lip care needs but also restores lips to a "youthful" state, brightens lip color, reduces lip lines, and makes lips fuller and more rosy.

[0039] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a Magnolia officinalis extract for lip care, characterized in that, Includes the following steps: (1) Grind the magnolia flowers into powder for later use; (2) Mix octanoic acid / capric acid triglyceride and isononyl isononanoate to obtain a composite solvent for later use; (3) Mix the Magnolia officinalis powder with the composite solvent and feed it into the microfluidic extractor. After discharge, the initial extract is prepared for use. (4) The initial extract was centrifuged and then filtered through a membrane to obtain the extract of Magnolia officinalis.

2. The method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, The mass ratio of caprylic / capric triglyceride and isononyl isononanoate when mixed in step (2) is 7:3-2:

3.

3. The method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, The mass ratio of the Magnolia officinalis powder to the composite solvent in step (3) is 1:3-1:

10.

4. The method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, The feeding rate mentioned in step (3) is 10-30 L / min.

5. A method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, The temperature of the microfluidic extractor described in step (3) is controlled at 20-30℃.

6. A method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, In step (3), the microjet extractor is used to control the pore size to be 500-800 μm, the rotation speed to be 500-1000 rpm, and the stirring time to be 60-120 min.

7. A method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, In step (4), the centrifugation speed is controlled at 4000-10000 rpm and the centrifugation time is controlled at 30-60 min.

8. A method for preparing a Magnolia officinalis extract for lip care according to claim 1, characterized in that, The membrane filtration described in step (4) specifically involves sequentially using a ceramic membrane with a pore size of 800 nm and a reverse osmosis membrane with a pore size of 0.5 nm for filtration.

9. An application of a Magnolia officinalis extract for lip care, characterized in that, The Magnolia officinalis extract is prepared by the method described in any one of claims 1-8, and is specifically used as an additive in the preparation of cosmetics.

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