Composition with functions of protecting liver and dispelling effects of alcohol

Abstract

The invention discloses a composition with liver protection and sobering functions, and belongs to the technical field of traditional Chinese medicine compositions. The composition provided by the invention has the functions of protecting the liver and dispelling the effects of alcohol; on one hand, the absorption of alcohol can be delayed; a drinker can control the drinking amount easily; on the other hand, raw materials are provided for enzyme synthesis, activity maintenance and antioxidant synthesis required by alcohol metabolism, and meanwhile, the raw materials are competitively combined with acetaldehyde, so that damage of acetaldehyde to liver cells is reduced; besides, after drinking, the active ingredients in the wine are rapidly dissolved in alcohol, so that the activity of ADH and ALDH is improved, anti-inflammatory and anti-oxidation effects are provided, and the purpose of protecting the liver is achieved; the effect of reducing harm caused by liver fat accumulation is also achieved; the safety is high; the preparation method is simple and easy to operate; the eating is convenient.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a composition with liver-protecting and hangover-relieving functions. Background Technology

[0002] The liver is the largest internal organ and "chemical factory" in the human body, undertaking a variety of irreplaceable physiological functions, mainly including: 1) Serving as the body's metabolic center. Carbohydrate, fat, and protein metabolism are all completed in the liver. 2) Leading the body's detoxification and elimination. It breaks down alcohol, drugs, environmental toxins, and metabolic waste, preventing organ damage caused by toxin accumulation and protecting overall health. 3) Synthesizing clotting factors and storing vitamins (A, D, E, K) and minerals such as iron and copper for the body's use when needed. 4) Secreting bile, which helps with fat digestion and the absorption of fat-soluble vitamins, excretes bilirubin, and prevents jaundice. 5) Immune cells in the liver can clear pathogens and enhance the body's resistance to infection.

[0003] Therefore, protecting the liver is not only crucial for preventing liver disease, but also for maintaining overall metabolic balance, detoxification capacity, and immune stability, making it vital for human health. In many cultures, drinking alcohol is a core ritual for socializing, celebrating, and building trust, and a means for many to relieve stress, anxiety, or negative emotions. However, alcohol is primarily metabolized in the liver, and its metabolites (such as acetaldehyde) are directly toxic to the liver. Acetaldehyde is far more toxic than ethanol, forming irreversible covalent bonds with proteins, directly damaging protein and enzyme activity, inducing immune responses and inflammation. High concentrations of ethanol in the blood can lead to severe and prolonged sedation, coma, and respiratory depression, posing a life-threatening risk. Alcohol metabolism also interferes with normal fat metabolism, causing a large accumulation of triglycerides in liver cells, leading to alcoholic fatty liver disease. If alcohol consumption is not completely stopped at this stage, liver cells are highly susceptible to inflammation and ballooning lesions, subsequently leading to alcoholic hepatitis, alcoholic liver fibrosis, and alcoholic cirrhosis, causing irreversible and severe damage to liver function and resulting in serious complications.

[0004] Currently, all medications for treating alcohol-induced liver disease require absolute abstinence from alcohol; any medication is ineffective if alcohol consumption continues. Side effects also include nausea, headache, abdominal pain, high blood pressure, high blood sugar, osteoporosis, and mood swings. Summary of the Invention

[0005] The purpose of this invention is to provide a composition with liver-protecting and hangover-relieving functions, that is, a composition that has both hangover-relieving and liver-protecting effects, and can exert a liver-protecting effect when the user drinks alcohol or does not absolutely abstain from alcohol.

[0006] To achieve the above objectives, the present invention provides a composition with liver-protecting and hangover-relieving functions, comprising the following components in parts by weight: 3-5 parts wolfberry extract, 4-6 parts Ganoderma lucidum powder, 5-7 parts Japanese raisin tree powder, 5-15 parts whey protein powder, and 5-15 parts oat flour.

[0007] Preferably, the wolfberry extract is prepared by the following method: Take fresh, mold-free, undyed, unsmoked, and untreated dried goji berries from the current year. Remove impurities, add sterile distilled water, soak at room temperature in the dark, homogenize, adjust pH, enzymatically hydrolyze, then freeze-dry in the dark, pulverize and sieve.

[0008] Preferably, the absence of pretreatment includes not adding sugar or soaking in sugar; removing impurities includes removing dust; and the amount of sterile distilled water added is 1-2 times the volume of the dried goji berries.

[0009] Preferably, the soaking is for 2-3 hours; the homogenization process ensures that the temperature of the homogenate does not exceed 40°C, and the homogenization is carried out for 5-20 minutes until the wolfberry seeds are crushed; the crushing and sieving is done through an 80-100 mesh sieve; the pH is adjusted to 6; and the enzymatic hydrolysis is performed using papain at 37-40°C for 10-20 minutes.

[0010] Preferably, the whey protein powder is hydrolyzed whey protein powder; the Hovenia dulcis powder is powder obtained by grinding the seeds of Hovenia dulcis and passing them through an 80-100 mesh sieve; and the oat powder is powder obtained by crushing raw oat flakes and passing them through an 80-100 mesh sieve.

[0011] Preferably, the components include the following parts by weight: 3 parts wolfberry extract, 4 parts Ganoderma lucidum powder, 6 parts Japanese raisin tree fruit, 8 parts whey protein powder, and 10 parts oat flour.

[0012] Preferably, the components include the following parts by weight: 4 parts wolfberry extract, 5 parts Ganoderma lucidum powder, 7 parts Japanese raisin tree fruit, 5 parts whey protein powder, and 12 parts oat flour.

[0013] Preferably, the components include the following parts by weight: 5 parts wolfberry extract, 6 parts Ganoderma lucidum powder, 5 parts Japanese raisin tree fruit, 15 parts whey protein powder, and 9 parts oat flour.

[0014] Preferably, the composition is stored in a vacuum, protected from light, at 4-18°C.

[0015] A method of consuming the composition described above, which has liver-protecting and hangover-relieving functions, is to take it with warm water not exceeding 40°C or chew it directly; the dosage is 10-15g / day / 50kg.

[0016] Goji berries ( Lycium chinense Lycium barbarum (also known as Ningxia wolfberry, Chinese wolfberry, etc.) is the ovoid berry of a perennial woody plant belonging to the Solanaceae family and the Lycium genus. It is a nutritious and health-promoting vegetable and a valuable traditional Chinese medicine, with both medicinal and edible properties. It is neutral in nature, sweet in taste, and enters the liver, kidney, and lung meridians. Its core component is Lycium barbarum polysaccharide, accounting for 5-10% of the dried fruit weight. This is the most important active ingredient in Lycium barbarum, possessing various biological functions such as immune regulation and antioxidation. It also contains 18 amino acids (including 8 essential amino acids), betaine, flavonoids, phenolic compounds, various minerals (rich in iron, zinc, selenium, potassium, calcium, etc.), and vitamins (including vitamins C, E, and B vitamins). Betaine, in particular, promotes lipid metabolism.

[0017] Reishi mushroom (Ganoderma lucidum) is a well-known medicinal fungus, known in Traditional Chinese Medicine as the "immortal herb" or "auspicious herb." Its main nutrients and active ingredients include: polysaccharides (primarily β-glucan), found in the fruiting body, spores, and mycelium; triterpenoids (the source of its bitterness, including ganoderic acids A, B, and C); and trace elements such as selenium and zinc. Among these, triterpenoids and polysaccharides can alleviate chemical and alcoholic liver damage, promote hepatocyte repair, inhibit liver fibrosis, and also have an auxiliary effect in lowering cholesterol and triglycerides; nucleosides have potential sedative effects and can improve blood circulation.

[0018] Hovenia dulcis, a plant belonging to the genus Hovenia dulcis in the family Rhamnaceae. Hovenia dulcis Thunnb. Hovenia acerba Lindl. and hairy hogaurus Hovenia trichocarpa The mature seeds of *Hovenia dulcis* are used both as food and medicine. They have a sweet and mild taste, and are neutral in nature, neither cold nor hot. They can enter the stomach meridian to clear stomach heat and stop vomiting, and also enter the spleen meridian to promote digestion. They are rich in flavonoids, vitamin C, organic acids (such as malic acid and citric acid), polysaccharides, *Hovenia dulcis* saponins, and alkaloids (hovenia dulcis alkaloids). The dihydromyricetin in the flavonoids, in addition to its antioxidant and anti-inflammatory effects, can enhance the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), promoting the breakdown of alcohol into harmless acetic acid and reducing acetaldehyde accumulation. *Hovenia dulcis* polysaccharides can form a protective film in the intestines, delaying alcohol absorption; the saponin components can protect brain nerves and relieve dizziness and nausea.

[0019] Oats are rich in soluble dietary fiber (β-glucan, accounting for about 54% of total oat fiber) and insoluble fiber. They are high in protein (about 12-15%), ranking among the top grains, with a relatively balanced amino acid composition, especially higher in lysine than other grains. They are also high in fat, primarily composed of healthy unsaturated fatty acids, with abundant linoleic acid (omega-6). Furthermore, they contain abundant B vitamins (thiamine (B1), pantothenic acid (B5), folic acid (B9)), and minerals such as manganese, phosphorus, magnesium, iron, and zinc. β-glucan can form a gel-like substance in the intestines, binding with bile acids and promoting cholesterol excretion, effectively lowering total cholesterol and "bad cholesterol." Oat anthraquinone is a unique and potent antioxidant found in oats, possessing strong anti-inflammatory and antioxidant properties, protecting vascular endothelial cells; it also combats atherosclerosis by reducing the oxidation of low-density lipoprotein, thus playing a protective role in blood vessels. Phytosterols can competitively inhibit cholesterol absorption in the intestines.

[0020] First, after consuming the composition provided by this invention before drinking alcohol, the water-soluble components (including Hovenia dulcis polysaccharide, Ganoderma lucidum polysaccharide, Lycium barbarum polysaccharide, protein / peptide / amino acid, vitamin C) and acid-soluble components (including minerals such as zinc, selenium, potassium, iron, etc.) contained therein dissolve first. Under the action of Hovenia dulcis polysaccharide, Ganoderma lucidum polysaccharide, Lycium barbarum polysaccharide, and oat flour, they stimulate the secretion of intestinal mucus, form a protective film in the gastrointestinal tract, and delay the absorption of alcohol.

[0021] The proteins, polypeptides of varying molecular weights, numerous amino acids, vitamins (such as vitamins C, E, and B6), and minerals (such as zinc and manganese) dissolved in the composition are absorbed by the small intestine. After drinking alcohol, these nutrients serve as raw materials for various enzymes (including enzymes that convert ethanol and acetaldehyde, and antioxidants) or neutralize / competitively bind with acetaldehyde, reducing the damage of acetaldehyde and ethanol to liver cells and ensuring the activity and quantity of enzymes. This promotes the rapid metabolism of ethanol and acetaldehyde and provides sufficient antioxidants (including glutathione, superoxide dismutase, and flavonoids and phenolic compounds from wolfberry and Japanese raisin tree fruit), enhancing the antioxidant capacity of cells, reducing secondary damage caused by acetaldehyde, and protecting the liver. Simultaneously, the wolfberry extract and hydrolyzed whey protein powder obtained through enzymatic hydrolysis contain a large amount of free amino acids and small molecule peptides, which are rapidly absorbed and utilized by the body. They also contain polypeptides and proteins of the same molecular weight, which, together with the large amounts of relatively large polypeptides / proteins in oat flour and Ganoderma lucidum powder, achieve the effect of continuously providing the body with nutrition and raw materials.

[0022] Furthermore, consuming the composition provided by this invention before drinking alcohol can enhance satiety, helping consumers who enjoy drinking to control their alcohol intake. The phytosterols in oat flour competitively inhibit cholesterol absorption in the intestines. The β-glucan in oat flour and Ganoderma lucidum powder, the triterpenoids and polysaccharides in Ganoderma lucidum, and the betaine in wolfberry work together to promote lipid metabolism / cholesterol excretion, reducing the liver's lipid metabolism stress and minimizing damage to liver cells caused by the accumulation of triglycerides.

[0023] After drinking alcohol, the fat-soluble substances in the composition, including dihydromyricetin and jujube saponins in jujube fruit, triterpenoids in Ganoderma lucidum, fat-soluble flavonoids and phenolic compounds in wolfberry, and polysaccharides in Ganoderma lucidum, have anti-inflammatory and antioxidant effects. On the other hand, they enhance the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), promote the metabolism of alcohol into harmless acetic acid, protect liver cells, and alleviate the damage to the liver caused by alcohol.

[0024] Meanwhile, the saponins in Hovenia dulcis can protect brain nerves and relieve dizziness and nausea, while the nucleosides in Ganoderma lucidum can improve irritability and promote blood circulation. In addition, the combination of ingredients before drinking promotes the formation of a protective film in the gastrointestinal tract, making it less likely for drinkers to experience symptoms of drunkenness (including dizziness, nausea and vomiting).

[0025] Therefore, the present invention provides a composition with liver-protecting and hangover-relieving functions, the specific technical effects of which are as follows: (1) The composition provided by the present invention has a light and fragrant taste and has the function of protecting the liver and sobering up. On the one hand, it can form a protective film in the gastrointestinal tract to delay the absorption of alcohol and increase the feeling of fullness, which helps drinkers control their drinking volume. On the other hand, when consumed 0.5-2 hours before drinking, the water-soluble amino acids, small molecule peptides and minerals contained therein are rapidly absorbed by the body, providing raw materials for the synthesis and activity maintenance of enzymes required for subsequent alcohol metabolism, as well as the synthesis of antioxidants. At the same time, the small molecule peptides transported to the liver can also competitively bind with acetaldehyde, reducing the damage of acetaldehyde to liver cells. In addition, when drinking alcohol, the fat-soluble components in it are rapidly dissolved in alcohol, increasing the activity of ADH and ALDH, providing anti-inflammatory and antioxidant effects, and achieving the purpose of protecting the liver. (2) The composition provided by the present invention has the effects of protecting brain nerves, relieving nausea, and improving irritability. At the same time, it promotes blood circulation and provides a guarantee for the transportation of each raw material. On the one hand, it reduces the transport of fat into the liver, and on the other hand, it promotes the excretion of fat from the liver, thereby reducing the pressure of liver fat metabolism and effectively reducing the harm caused by liver fat accumulation. Combined with specific consumption time, it has good hangover relief and liver protection effects. (3) The compositions provided by the present invention are all Chinese medicines or foods that are both food and medicine, and do not use toxic or harmful reagents and materials, so they are highly safe; the preparation method is simple and easy to operate; they are convenient to eat, and can be taken with warm water at a temperature not higher than 40°C or chewed directly; when consumed according to the dosage provided by the present invention, no adverse effects have been observed.

[0026] The technical solution of the present invention will be further described in detail below through embodiments. Detailed Implementation

[0027] The technical solution of the present invention will be further described below through embodiments.

[0028] To make the objectives, technical solutions, and advantages of this application clearer, more thorough, and more complete, the technical solutions of the present invention are clearly and completely described below through embodiments. The following detailed descriptions are all illustrations of embodiments, intended to provide further detailed explanations of the present invention. Unless otherwise specified, all technical terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.

[0029] The instruments, equipment, reagents and materials used in the embodiments were all obtained through commercial means; the methods and steps not described in detail in the embodiments are all conventional techniques in the art.

[0030] Example 1 The specific steps for preparing a wolfberry extract are as follows: S1. Purchase Ningxia wolfberries that are uniform in size, plump, round and firm, and bright red or dark red in color (avoid overly bright colors). Some may have a slight white frost on the surface, are not sticky or soft, have a faint grassy smell, and are free from unpleasant odors and mold. Use a fan to remove surface dust and dry leaf fragments and other impurities. Take 200g and rinse it quickly with sterile drinking water.

[0031] S2. Add the rinsed goji berries to a light-proof container, then add 1.5 times the volume of sterile drinking water. Soak at room temperature in the dark for 3 hours, then homogenize in the dark until all goji berry seeds are crushed. During this process, use ice baths and intermittent cooling to keep the temperature of the homogenate below 40°C.

[0032] S3. The pH of the slurry was adjusted to about 6 using 1M NaOH and 1M HCl. Then, papain (enzyme activity of 10000U) was added to the mixture and enzymatically hydrolyzed at 40℃ for 15-20 minutes. The mixture was then freeze-dried under light-protected conditions and pulverized through a 100-mesh sieve to obtain the wolfberry extract, weighing about 194g. It was stored under vacuum, light-protected conditions at 4℃.

[0033] Example 2 The preparation of Japanese raisin tree seed powder and oat flour is as follows: (1) Preparation of Hovenia dulcis powder. Take dried, plump, insect-free, mold-free, uniformly colored and glossy Hovenia dulcis seeds from the current year, remove dust and other impurities, and crush them through a 100-mesh sieve to obtain Hovenia dulcis powder.

[0034] (2) Preparation of oat flour. Purchase dried oats produced in the current year, and make raw oat flakes (note that there should be no mold; if there is a whole package, discard it) by rolling technology after the oats have been dehulled and moderately peeled (without any other treatment, including adding sugar, oil, or preservatives). Grind the oats through a 100-mesh sieve to obtain oat flour.

[0035] Example 3 A composition with liver-protecting and hangover-relieving functions was prepared, as follows: Take 3g of wolfberry extract prepared in Example 1, 4g of Ganoderma lucidum spore powder, 6g of Japanese raisin tree seed powder prepared in Example 2, 8g of hydrolyzed whey protein powder, and 10g of oat flour prepared in Example 2. Mix them at room temperature and in the dark, spray with sterile distilled water, and prepare them into tablets, each weighing 3g. Store them in a vacuum, sealed, dark place at 4°C.

[0036] Example 4 A composition with liver-protecting and hangover-relieving functions was prepared, as follows: Take 4g of wolfberry extract prepared in Example 1, 5g of Ganoderma lucidum spore powder, 7g of Japanese raisin tree seed powder prepared in Example 2, 5g of hydrolyzed whey protein powder, and 12g of oat flour prepared in Example 2. Mix them at room temperature and in the dark, spray with sterile distilled water, and prepare them into tablets, each weighing 3g. Store them in a vacuum, sealed, dark place at 4°C.

[0037] Example 5 A composition with liver-protecting and hangover-relieving functions was prepared, as follows: Take 5g of wolfberry extract prepared in Example 1, 6g of Ganoderma lucidum spore powder, 5g of Japanese raisin tree seed powder prepared in Example 2, 15g of hydrolyzed whey protein powder, and 9g of oat flour prepared in Example 2. Mix them at room temperature and in the dark, spray with sterile distilled water, and prepare them into tablets, each weighing 3g. Store them in a vacuum, sealed, dark place at 4°C.

[0038] Comparative Example 1 A composition was prepared using the same method as in Example 3, except that wolfberry extract was not added.

[0039] Comparative Example 2 A composition was prepared using the same method as in Example 3, except that oat flour was not added.

[0040] Example 1 The effects of the compositions prepared in Example 3, Comparative Example 1, and Comparative Example 2 on hangover relief and liver protection were investigated as follows: Twenty-four SPF-grade male ICR mice (20±2g, 8 weeks old) were randomly divided into four groups of six after a two-week acclimatization period. After a 12-hour fast, the mice were used for the experiment. The control group received 20 mL / kg of 53% (v / v) liquor via gavage, followed by 1 mL of distilled water one hour before gavage, for three consecutive days. The Example 3 group received 20 mL / kg of 53% (v / v) liquor via gavage, followed by 1 mg of the composition prepared in Example 3 (prepared by adding 1 mL of distilled water to form a suspension before gavage) one hour before gavage, for three consecutive days. The Comparative Example 1 group received 20 mL / kg of 53% (v / v) liquor via gavage, followed by 1 mg of the composition prepared in Comparative Example 1 (prepared by adding 1 mL of distilled water to form a suspension before gavage), one hour before gavage, for three consecutive days. In Comparative Example 2, mice were administered 1 mg of the composition prepared in Comparative Example 1 by gavage 1 hour before drinking 53% (v / v) liquor at a dose of 20 mL / kg (the mixture was added to 1 mL of distilled water to form a suspension before gavage). Mice in each group were administered the mixture by gavage for 3 consecutive days.

[0041] The intoxication time was recorded from the moment the mouse was given baijiu (Chinese liquor) via gavage, when the righting reflex disappeared (the mouse was gently placed back-down in the cage; if it remained in this position for more than 30 seconds, the righting reflex was considered to have disappeared). The sleep duration was recorded from the time the righting reflex disappeared until it recovered. After the righting reflex recovered, the mouse was placed on a vertical metal mesh, and the time it took for the mouse to fall off the mesh was recorded as the time it spent clinging to the mesh. The statistical results are shown in Table 1.

[0042] Table 1. Statistical results of intoxication time, sleep duration, and clinging time.

[0043] Note: Indicates a comparison with the control group P <0.05; Indicates a comparison with the control group P <0.001 As can be seen from Table 1, the composition prepared in Example 3 of the present invention has the effect of sobering up. Compared with the same amount of distilled water administered by gavage before drinking, it can significantly reduce the time of drunkenness and the duration of sleep, and significantly increase the time of hangover. The composition in Example 3 has the best effect. The oat flour and wolfberry extract in the components have important (synergistic) effects on the effect. The effect is not good if oat flour or wolfberry extract is missing. The effect is worse if wolfberry extract is missing.

[0044] After the third oral administration of baijiu (Chinese liquor), the mice were kept on a fasting but not on a water-free basis. After anesthesia, the eyeballs were enucleated and blood was collected. The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured using a kit to examine the liver function of each group of mice. The results are shown in Table 2.

[0045] Table 2. Results of Aspartate Aminotransferase and Alanine Aminotransferase Determination

[0046] Note: Indicates a comparison with the control group P <0.05; Indicates a comparison with the control group P <0.001 As shown in Table 2, the liver function test results were consistent with the hangover relief results. Compared with the control group who were given distilled water by gavage before drinking, the composition prepared in Example 3 of this invention significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase. Among them, the composition prepared in Example 3 showed the best effect, indicating that the components work synergistically as a whole and can achieve a good protective effect on the liver after drinking.

[0047] Therefore, the composition provided by this invention has the functions of protecting the liver and sobering up. On the one hand, it can delay the absorption of alcohol, helping drinkers control their intake. On the other hand, it provides raw materials for the synthesis and activity maintenance of enzymes required for alcohol metabolism, as well as for the synthesis of antioxidants. At the same time, it competitively binds to acetaldehyde, reducing the damage of acetaldehyde to liver cells. In addition, after drinking, the effective components in the composition quickly dissolve in alcohol, increasing the activity of ADH and ALDH, providing anti-inflammatory and antioxidant effects, and achieving the purpose of protecting the liver. It also has the effect of reducing the harm caused by fat accumulation in the liver. It has high safety, the preparation method is simple and easy to operate, and it is convenient to consume.

[0048] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A composition with liver-protecting and hangover-relieving functions, characterized in that, It includes the following components by weight: 3-5 parts wolfberry extract, 4-6 parts Ganoderma lucidum powder, 5-7 parts Japanese raisin tree powder, 5-15 parts whey protein powder, and 5-15 parts oat flour.

2. The composition with liver-protecting and hangover-relieving functions according to claim 1, characterized in that, The wolfberry extract is prepared by the following method: Take fresh, mold-free, undyed, unsmoked, and untreated dried goji berries from the current year. Remove impurities, add sterile distilled water, soak at room temperature in the dark, homogenize, adjust pH, enzymatically hydrolyze, then freeze-dry in the dark, pulverize and sieve.

3. The composition with liver-protecting and hangover-relieving functions according to claim 2, characterized in that: The absence of pretreatment includes not adding sugar or soaking in sugar; removing impurities includes removing dust; and adding sterile distilled water in an amount of 1-2 times the volume of dried goji berries.

4. The composition with liver-protecting and hangover-relieving functions according to claim 2, characterized in that: The soaking process involves soaking for 2-3 hours; the homogenization process ensures that the temperature of the homogenate does not exceed 40℃ and the homogenization time is 5-20 minutes until the wolfberry seeds are crushed; the crushed seeds are sieved through an 80-100 mesh sieve; the pH is adjusted to 6; and the enzymatic hydrolysis is performed using papain at 37-40℃ for 10-20 minutes.

5. The composition with liver-protecting and hangover-relieving functions according to claim 4, characterized in that: The whey protein powder is hydrolyzed whey protein powder; the jujube seed powder is powder made from the seeds of the jujube tree after grinding and passing through an 80-100 mesh sieve; the oat powder is powder made from raw oat flakes after crushing and passing through an 80-100 mesh sieve.

6. The composition with liver-protecting and hangover-relieving functions according to claim 5, characterized in that, The product contains the following components by weight: 3 parts wolfberry extract, 4 parts Ganoderma lucidum powder, 6 parts Japanese raisin tree fruit, 8 parts whey protein powder, and 10 parts oat flour.

7. The composition with liver-protecting and hangover-relieving functions according to claim 5, characterized in that, The product contains the following components by weight: 4 parts wolfberry extract, 5 parts Ganoderma lucidum powder, 7 parts Japanese raisin tree fruit, 5 parts whey protein powder, and 12 parts oat flour.

8. The composition with liver-protecting and hangover-relieving functions according to claim 5, characterized in that, The product contains the following components by weight: 5 parts wolfberry extract, 6 parts Ganoderma lucidum powder, 5 parts Japanese raisin tree fruit, 15 parts whey protein powder, and 9 parts oat flour.

9. The composition with liver-protecting and hangover-relieving functions according to claim 5, characterized in that: The composition shall be stored in a vacuum, protected from light, at 4-18°C.

10. A method of consuming a composition with liver-protecting and hangover-relieving functions as described in any one of claims 1-9, characterized in that: The method of consumption is to take it with warm water not exceeding 40℃ or chew it directly; the dosage is 10-15g / day / 50kg.

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