Synthetic reaction full-stack workstation and use method

Abstract

The invention discloses a synthetic reaction full-stack workstation and a use method, the synthetic reaction full-stack workstation comprises a workstation main body, a working space is arranged in the workstation main body, and a synthetic reaction is executed in the working space; a reaction area, a material preparation area and a mechanical arm are arranged in the working space; wherein the material preparation area comprises a material preparation module, a powder distribution module and a liquid transferring module, and the liquid transferring module is used for quantitatively sucking liquid in a liquid raw material bottle and transferring the liquid into a reaction bottle; the pretreatment module is used for carrying out gas filling and oscillation operation on the reaction bottle; and the synthesis reaction module is internally provided with reaction channels of a plurality of areas. According to the invention, full-automatic high-flux synthesis reaction can be realized, solid raw materials and liquid raw materials can be automatically, quantitatively and accurately injected into the reaction bottle in the reaction preparation stage, and meanwhile, the accuracy of injection of the solid raw materials can be ensured through the oscillation and air-entrapping module in the pretreatment module, so that the accurate execution of the synthesis reaction is ensured.

Description

Technical Field

[0001] This invention belongs to the field of chemical synthesis experimental technology, specifically relating to a full-stack workstation for synthesis reactions and its usage. Background Technology

[0002] High-throughput chemical synthesis is a chemical research method that mainly utilizes automated equipment technology to rapidly and efficiently carry out a large number of chemical synthesis reactions, accelerating the discovery and optimization of new compounds or new materials, thereby speeding up the research and development of new drugs and materials.

[0003] Existing chemical synthesis experimental platforms and related equipment require precise addition of raw materials, including both solid and liquid raw materials, to ensure the accuracy of experiments during large-scale synthesis reactions. However, when adding solid raw materials, the existing reagent addition process cannot guarantee that the dosage is completely consistent each time. Furthermore, during the injection of solid raw materials into the reaction flask, some raw materials adhere to the inner wall of the upper part of the flask. This results in the effective reaction dose of solid raw materials being lower than the theoretical reaction dose during the synthesis reaction, thus affecting the accuracy of the reaction and even causing reaction failure.

[0004] Existing technologies, such as the high-throughput automated chemical synthesis workstation disclosed in CN120827834A, can complete high-throughput chemical synthesis experiments within a single workstation, from pipetting, sealing the reaction system, opening the reaction, gradient dilution, and filtration. However, it mainly relies on precise volume control of liquids using a pipette, and still cannot effectively solve the aforementioned problems. Summary of the Invention

[0005] The purpose of this invention is to propose a full-stack workstation for synthetic reactions and its usage method to solve the problems in the prior art.

[0006] Therefore, the present invention provides a full-stack workstation for synthetic reactions, characterized in that it includes: The main body of the workstation includes a workspace within which a synthetic reaction is performed. The workspace is equipped with a reaction area, a material preparation area, and a robotic arm. The robotic arm transports the reaction flasks that have been prepared in the material preparation area to the reaction area for synthesis reaction. The material preparation area includes a material preparation module, which comprises multiple solid raw material bottles, multiple liquid raw material bottles, and a consumable storage box; and A powder dispensing module, which can be used to place a solid raw material bottle at the feed inlet and quantitatively and accurately dispense fixed reagents into the reaction flask below; A liquid pipetting module is used to quantitatively aspirate liquid from the liquid raw material bottle and transfer it to the reaction bottle; The pretreatment module is used to add gas and shake the reaction flask. The synthesis reaction module has multiple reaction channels for temperature control and stirring of the reaction flask.

[0007] In some embodiments, a barcode scanning module is also included. The solid raw material bottle, the liquid raw material bottle, and the reaction bottle are all covered with a unique identification code. The barcode scanning module is used to scan the unique identification code to obtain identification information during sample transfer and reagent addition, and upload the identification information to the data management system.

[0008] In some embodiments, a temperature monitoring module is further included, which is used to monitor the temperature of the reaction zone and the preparation zone in real time.

[0009] In some embodiments, a video monitoring module is also included, which is used to monitor the abnormal status of the reaction area and the material preparation area in real time.

[0010] In some embodiments, the data management system is used to record reaction parameters during the experiment and to export an experimental report after the reaction is completed.

[0011] In some embodiments, the pretreatment module includes a shaking module and a gas-adding module. The shaking module is used to shake the reaction flask containing the added solid and liquid raw materials, and the gas-adding module is used to introduce an inert gas into the reaction flask.

[0012] In some embodiments, the synthesis reaction module includes multiple reaction zones, and the multiple reaction zones have different temperature zones, with a heat insulation plate disposed between adjacent reaction zones.

[0013] On the other hand, a method for using a full-stack synthetic reaction workstation is also provided, including: Receive the input experimental task parameters; The barcode scanning module reads the identification information of the solid raw material bottles and the liquid raw material bottles, and compares the identification information with the experimental task parameters; Place the reaction flasks into the feeding positions one by one; The robotic arm grasps the solid raw material bottle and installs it into the powder dispensing module, which quantitatively injects the solid reagent into the reaction bottle. The pipetting module draws a preset dose of liquid reagent from the liquid raw material bottle and injects it into the reaction bottle; The robotic arm picks up the reaction bottle containing the solid and / or liquid reagents and places it into the synthesis reaction module for a stirred reaction at a preset temperature; After the reaction is complete, the robotic arm moves the reaction flask back to its original position, connects it to an analytical instrument for testing, and outputs an experimental report.

[0014] In some embodiments, before transferring the reaction flask to the synthesis reaction module, the robotic arm grasps the reaction flask and places it into a pretreatment module for agitation and / or gasification.

[0015] In some embodiments, during the reaction process, the AI ​​video monitoring unit collects image data of the reaction area in real time and processes the image data using an image recognition algorithm to automatically identify reagent leakage, container breakage, or abnormal reaction status. When an anomaly is detected or a reaction parameter exceeds a safety threshold, the control system automatically triggers an alarm and executes a predetermined safety intervention procedure.

[0016] Beneficial effects: This invention enables fully automated, high-throughput synthesis reactions. During the reaction preparation stage, solid and liquid raw materials are automatically and precisely injected into the reaction flask. Simultaneously, the oscillation and gasification modules in the pretreatment module ensure the accuracy of solid material injection, thereby guaranteeing the precise execution of the synthesis reaction. During the reaction stage, a large number of reaction flasks can be reacted simultaneously through the synthesis reaction module. Furthermore, different areas of the synthesis reaction module can be heated to different temperatures, allowing multiple synthesis reactions at different temperatures to proceed simultaneously, improving reaction efficiency. Additionally, this application includes a video monitoring module for real-time image recognition during the reaction process, accurately identifying abnormal states and providing alerts. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is an external schematic diagram of the full-stack workstation for the synthesis reaction provided by the present invention.

[0019] Figure 2 This is a partial internal schematic diagram of the full-stack workstation for the synthesis reaction provided by the present invention.

[0020] Figure 3 This is a partial internal schematic diagram of the full-stack workstation for the synthesis reaction provided by the present invention.

[0021] Figure 4 A flowchart illustrating the usage of the full-stack workstation for synthetic reactions provided by this invention.

[0022] Figure 5 The flowchart shows the full-stack workstation for the synthesis reaction and its usage method provided by the present invention.

[0023] In the diagram: 1. Main body of the workstation; 2. Reaction area; 3. Material preparation area; 4. Robotic arm; 5. Solid raw material bottle; 6. Liquid raw material bottle; 7. Consumable storage box; 8. Powder dispensing module; 9. Liquid transfer module; 10. Pretreatment module; 11. Synthesis reaction module; 12. Barcode scanning and identification module; 13. Reaction flask. Detailed Implementation

[0024] The invention will be more readily understood by referring to the following detailed description of preferred embodiments and included examples. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In case of conflict, the definitions in this specification shall prevail.

[0025] like Figure 1-3 As shown, a synthetic reaction full-stack workstation includes: The workstation body 1 contains a workspace for performing the synthesis reaction. The workstation body 1 is a box-like structure with an openable glass door on the outside of the workspace. This door allows for manual operation of the components within the workspace. The workstation body 1 is constructed of explosion-proof and flame-retardant materials, achieving an IP54 protection rating, which can withstand sudden temperature increases and minor reagent leaks in the event of a runaway reaction, thus reducing safety risks.

[0026] The workspace includes a reaction zone 2, a material preparation zone 3, and a robotic arm 4. The robotic arm 4 transports the prepared reaction flasks 13 from the material preparation zone 3 to the reaction zone 2 for the synthesis reaction. The robotic arm 4 is equipped with a robotic hand at its end, which can grasp the solid raw material flasks 5, liquid raw material flasks 6, and reaction flasks 13, thus providing a basis for subsequently moving these three components to designated locations. Simultaneously, the robotic arm 4 achieves millimeter-level motion precision, accurately docking with key areas such as the powder dispensing module 8, the liquid transfer module, and the reaction zone, replacing manual labor in repetitive mechanical operations and avoiding human error.

[0027] The preparation area 3 includes a preparation module comprising multiple solid raw material bottles 5, multiple liquid raw material bottles 6, and a consumable storage box. Preparation area 3 is used to precisely add solid and liquid raw materials to reaction flask 13 according to experimental parameters. It also includes a storage area for consumables such as pipette tips. When the pipetting module needs to inject liquid from a liquid raw material bottle 6 into reaction flask 13, it first connects to the pipette tip before aspiration. Furthermore, a waste collection box is provided in preparation area 3, allowing pipette tips to be discarded directly after use for greater convenience. The powder dispensing module 8 is used to place the solid raw material bottle 5 at the inlet and to quantitatively and accurately dispense fixed reagents into the reaction flask 13 below. Specifically, the powder dispensing module 8 consists of four independent powder dispensing units, each of which includes an inlet, a precision metering device, and a dispensing outlet.

[0028] This module can handle solid reagents ranging from 1 mg to 200 g, with a dispensing error controlled within ±1%. During operation, robotic arm 4, following instructions from the control system, retrieves the designated solid raw material bottle 5 from the storage location in preparation area 3, transports it, and securely places it at the inlet of a powder dispensing unit. Once the bottle is in place, the unit's metering device begins operation, extracting powder from the bottle according to the mass set for the experimental task and precisely injecting it into the waiting reaction flask 13 below via the dispensing outlet. After completing one dispensing cycle, robotic arm 4 can return the bottle to its original storage location and continue retrieving new bottles for the next task. Each powder dispensing unit has an independent feeding channel and control system, enabling the four units to work in parallel and process different solid reagents simultaneously, thus meeting the rapid and diverse solid feeding requirements of high-throughput experiments.

[0029] The liquid pipetting module is used to quantitatively aspirate the liquid in the liquid raw material bottle 6 and transfer it to the reaction bottle 13. Specifically, the liquid pipetting module includes two independently operating high-precision pipetting channels with a pipetting accuracy of ±0.5%.

[0030] This module is located adjacent to the material preparation area 3, which has a bottle position that can accommodate 16 standard liquid raw material bottles 6 on its side or above. Each pipetting channel is equipped with an automatically replaceable disposable pipette tip gripper.

[0031] During operation, the control system, based on experimental task instructions, first drives the robotic arm 4 to pick up a sterile pipette tip from the consumable storage box and attach it to the gripper of the designated pipetting channel. Subsequently, the movement mechanism of this pipetting channel moves the pipette tip above the target liquid source bottle 6, lowers it, and inserts it below the liquid surface. Using a built-in precision piston pump or syringe pump mechanism, a predetermined volume of liquid reagent is drawn. After aspiration, the pipetting channel, carrying the liquid-laden tip, moves above the target reaction bottle 13 and precisely injects the liquid into the bottle. After one dispensing task is completed, the robotic arm 4 can remove the used tip to the waste container and install a new tip for the next pipetting task. The two pipetting channels can work independently or collaboratively, capable of sequentially or simultaneously drawing different liquids from one or more source bottles and adding them to one or more reaction bottles 13, thereby achieving flexible, cross-contamination-free, automated quantitative addition of liquid reagents.

[0032] Pretreatment module 10, which is used to add gas and shake the reaction flask 13; The synthesis reaction module 11 is provided with multiple reaction channels for temperature regulation and stirring of the reaction flask 13.

[0033] By integrating the material preparation area 3 and the reaction area 2 into the same workstation body 1, and using a robotic arm 4 to achieve automated logistics connection between the two, seamless automation of the entire process from precise addition of solid / liquid raw materials and pretreatment to reaction initiation has been achieved for the first time. Specifically, the powder distribution module 8 addresses the industry challenge of automated and precise weighing and addition of solid reagents; the pretreatment module 10 ensures complete transfer and initial mixing of solid reagents through oscillation and meets the requirements of a special reaction atmosphere through gas addition; and the multi-channel design of the synthesis reaction module 11 supports high-throughput parallel reaction capabilities. The entire system constitutes a full-stack solution, greatly reducing manual intervention, significantly improving the efficiency, consistency, and repeatability of synthesis experiments, while also automating hazardous chemical synthesis experiments, reducing the probability of human contact, and improving safety.

[0034] In one embodiment, the pretreatment module 10 includes a shaking module and a gas-adding module. The shaking module is used to shake the reaction bottle 13 into which solid raw materials and liquid raw materials have been added, and the gas-adding module is used to introduce inert gas into the reaction bottle 13.

[0035] Specifically, the pretreatment module 10 is an independent automated workstation, comprising a shaking unit and a gas-adding unit. This module is equipped with a positioning platform for receiving and securing the reaction bottle 13 transferred there by the robotic arm 4. Once the reaction bottle 13 is in place, shaking, gas-adding, or both sequentially can be performed according to the experimental procedure.

[0036] The oscillation unit includes a mechanical clamp that holds the body of reaction flask 13 and a drive mechanism. Once activated, the drive mechanism causes the clamped reaction flask 13 to undergo rapid, small-amplitude horizontal reciprocating oscillation or vertical vibration, the duration of which can be adjusted according to a preset program. This operation aims to use physical vibration to completely dissolve solid reagent powder adhering to the flask wall or mouth into the liquid at the bottom of the flask, promoting initial mixing of the solid and liquid to form a homogeneous suspension, thus creating conditions for subsequent reactions.

[0037] The gas supply unit includes an inert gas source, a pressure regulating valve, a flow metering device, and a venting arm with a sealing needle at one end. When gas supply is required, the venting arm descends under the drive of the driving device, inserting its sealing needle into the sealing gasket at the mouth of the reaction flask 13. Subsequently, the pressure regulating valve and the flow meter operate according to set parameters, introducing inert gas at a specific flow rate and for a specific time into the reaction flask 13 to replace and remove the air inside the flask, providing an environment for chemical reactions requiring an oxygen-free or inert atmosphere. After gas supply is completed, the venting arm rises back to its original position, and the robotic arm 4 can then transfer the processed reaction flask 13 to the next workstation.

[0038] In one embodiment, a barcode scanning module 12 is also included. The solid raw material bottle 5, the liquid raw material bottle 6, and the reaction flask 13 are all affixed with unique identification codes. The barcode scanning module 12 is used to scan the unique identification codes during sample transfer and reagent addition to obtain identification information and upload the identification information to the data management system. Specifically, the barcode scanning module 12 can be a high-resolution industrial-grade barcode scanner. During operation, when the robotic arm 4 picks up any raw material bottle or reaction flask 13 and passes under the barcode scanner, the scanner is triggered and automatically performs a rapid scan of the identification code on the bottle to read the encoded information. For example, the barcode scanner will perform a scan before the robotic arm 4 picks up a solid raw material bottle 5 to send it to the powder dispensing module 8, or when moving a reaction flask 13 that has been filled with materials to the pretreatment module 10.

[0039] The coded information read by the barcode scanner is immediately uploaded to the workstation's data management system via data cable or wireless network. The data management system compares the received identification code with the currently executed experimental task list to verify whether the bottle is the correct raw material or sample required for the current step. After successful verification, the system records the time of the scan, the bottle code information, and the corresponding experimental step, thereby achieving precise traceability of the usage of each container throughout the entire experimental process. If the scanned identification code does not match the task, the system will immediately send an alarm signal to the control system and suspend the subsequent operation of robotic arm 4 to prevent the addition of incorrect reagents.

[0040] In one embodiment, a temperature monitoring module is further included, which is used to monitor the temperature of the reaction zone 2 and the preparation zone 3 in real time. The temperature monitoring module consists of multiple high-precision temperature sensors, which are respectively deployed inside or near each reaction channel in the reaction zone 2, and in the centralized storage area for solid and liquid raw materials in the preparation zone 3. The sensors communicate in real time with the workstation's control system via wiring.

[0041] During the reaction, temperature sensors in each reaction channel continuously measure the real-time temperature at their location, and the measurement data is sent to the control system several times per second. The control system compares the received real-time temperature data with the target temperature value preset for that channel in the experimental task. For example, when the set reaction temperature for a channel is 150°C, the sensor will continuously monitor whether the actual temperature is stable near the set value. At the same time, sensors in the material preparation area 3 monitor the temperature of the raw material storage environment to ensure that the reagents are stored under stable conditions and to avoid deterioration due to excessively high or low ambient temperatures.

[0042] The control system has pre-set safety thresholds for various temperatures. If any sensor reading exceeds its corresponding safety threshold—for example, if the temperature in a reaction channel abnormally rises above 200°C, or the temperature in the raw material storage area falls below the permissible low temperature—the control system will immediately trigger a two-stage response. First, a prominent visual alarm will pop up on the operating interface, accompanied by an audible alert. Second, the emergency procedure associated with that area will be automatically executed. For overheating in the reaction zone, the emergency procedure may include immediately cutting off the heating power to that channel, activating the active cooling fan or Peltier cooler for that area. For severe overheating of the entire system, an order may be issued to stop all heating operations and instruct robotic arm 4 to pause its movement. All temperature data and alarm events are synchronously recorded in the data management system for subsequent report generation and accident tracing.

[0043] In one embodiment, a video monitoring module is also included, which is used to monitor the abnormal status of the reaction zone 2 and the preparation zone 3 in real time. The video monitoring module includes three high-definition industrial cameras, each fixedly installed above the interior space of the workstation. Their fields of view cover all reaction channels in the reaction zone, the raw material bottle storage areas in the preparation zone, and the main movement trajectory area of ​​the robotic arm 4, respectively. These cameras continuously record video while the workstation is running.

[0044] During the experiment, the real-time video stream captured by the camera was transmitted to a separate image processing unit. This unit ran a trained computer vision recognition algorithm. The algorithm analyzed each video frame to automatically identify specific abnormal states in the footage. For example, it could identify indicator reagent leakage below reaction flask 13, abnormal cracks or damage to the body of reaction flask 13, a sudden increase in abnormal foaming or splashing within the reaction system, and localized areas of abnormal temperature identified through auxiliary thermal imaging or color changes.

[0045] Once the image processing algorithm identifies any of the aforementioned preset anomaly patterns, it immediately sends a digital signal containing the anomaly type and location to the workstation's main control system. Upon receiving this signal, the control system immediately executes a series of preset safety intervention procedures. Typical interventions include: displaying a full-screen warning on the user interface and activating the audible and visual alarms; sending an emergency stop or action command to the actuator responsible for the anomaly area; and simultaneously recording all relevant video clips, timestamps, and system response actions of the anomaly event completely into the data management system for subsequent review and analysis. The entire process requires no manual observation of the screen, achieving fully automated and visualized safety monitoring of the experiment.

[0046] In one embodiment, the synthesis reaction module 11 includes multiple reaction zones 2, each with a different temperature range, and a temperature insulation plate is provided between adjacent reaction zones 2. The synthesis reaction module 11 is equipped with a 60-channel reaction unit, accommodating 120 standard reaction flasks 13 (two batches), and each reaction channel is equipped with an independent stirring rotor and drive device.

[0047] Specifically, the synthesis reaction module 11 is an integrated reaction unit array, physically divided into five independent reaction zones 2. Each zone is isolated from the others by a temperature-insulating plate, thus forming five independently controllable temperature environments, i.e., different temperature zones. The entire module provides a total of 60 physical reaction channels, each designed to accommodate a standard reaction flask 13. To adapt to high-throughput requirements, the system adopts a two-batch processing mode, i.e., it can continuously process a total of 120 reaction flasks 13 at a time.

[0048] At the bottom or side of each reaction channel, an independent Peltier semiconductor temperature control element, heating wire, and temperature sensor are installed, together forming a closed-loop temperature control system for that channel. This system allows each reaction channel to be precisely fine-tuned within its overall temperature range setting, achieving a wide temperature control range from -40℃ to 320℃, with the entire module achieving a temperature control accuracy of ±0.5℃.

[0049] Meanwhile, each reaction channel is equipped with an independent stirring device, which includes a magnetic stirring rotor that can be raised or fixed, and a corresponding magnetic drive motor outside the channel. The drive motor drives the rotor inside the bottle to rotate via electromagnetic coupling, and the stirring speed can be steplessly adjusted within the range of 100 to 1500 revolutions per minute (rpm). The control system can independently issue different stirring start / stop and speed commands to each channel.

[0050] During operation, robotic arm 4 first places the first batch of 60 prepared reaction flasks 13 into the 60 reaction channels sequentially. The control system then sets the target temperature and stirring speed for each channel or temperature zone according to the preset experimental program. The temperature control system activates, rapidly bringing the reaction system to and stabilizing at the target temperature, while the stirring device starts to ensure uniform mixing of the reactants. When the first batch of reactions is underway or completed, robotic arm 4 can remove the first batch of reaction flasks 13 and place the second batch of 60 reaction flasks 13 into the system, beginning a new round of reaction. This is equivalent to the workload of one experimenter for eight days, significantly increasing experimental throughput. In this way, the module achieves parallel, continuous, and automated processing of large-scale reactions under multiple temperature conditions.

[0051] In one embodiment, the control system of the entire workstation is equipped with a computer operating screen, which supports one-click batch import of experimental tasks from Excel spreadsheets. Specific parameters include the type and dosage of materials, reaction temperature, stirring speed, feeding sequence, and reaction time. It also features a customizable experimental workflow editing function. The data management system automatically records various parameters during the experiment, such as temperature, stirring speed, reaction time, material quantity, and equipment operating status, generating exportable experimental reports and supporting cloud storage and traceability of experimental data. Furthermore, it can continuously iterate based on historical experimental data, automatically optimizing parameters such as the feeding ratio and reaction temperature for subsequent experiments to improve reaction success rate and efficiency.

[0052] On the other hand, the present invention also provides a method for using a full-stack synthetic reaction workstation, comprising: The system receives input experimental task parameters. Specifically, users can edit experimental parameters or directly import experimental task sheets in Excel format through the control system's touch screen or accompanying computer software, specifying parameters such as the type, dosage, order of feeding, reaction temperature, stirring speed, and reaction time for each reaction channel. After confirmation, the system issues experimental instructions.

[0053] Then, solid reagents are loaded into 120 solid raw material bottles 5 and liquid reagents are loaded into 16 liquid raw material bottles 6. The reaction flask 13 and disposable pipette tips are placed in the corresponding storage slots. The barcode scanning module reads the identification information of the solid raw material bottles 5 and the liquid raw material bottles 6, and the identification information is compared with the experimental task parameters.

[0054] The reaction flasks 13 are placed into the feeding position in sequence. Specifically, according to the instructions of the control system, the robotic arm 4 picks up 120 reaction flasks 13 from the storage position of the reaction flasks 13 and transfers them in two batches to the feeding position or the 60 channel unit of the reaction zone, thus completing the positioning and placement of the reaction flasks 13.

[0055] The robotic arm 4 grasps the solid raw material bottle 5 and installs it on the powder dispensing module 8. The powder dispensing module 8 then quantitatively injects the solid reagent into the reaction bottle 13. Specifically, the robotic arm 4 grasps the corresponding solid raw material bottle 5 according to instructions and installs it on four powder dispensing modules 8. The powder dispensing modules 8 then inject the reagent into the corresponding reaction bottle 13, completing the automatic feeding of solid reagents.

[0056] The pipetting module draws a preset dose of liquid reagent from the liquid raw material bottle 6 and injects it into the reaction bottle 13. Specifically, the pipetting module draws a set dose of liquid reagent from the liquid raw material bottle 6 and precisely injects it into the reaction bottle 13 to achieve quantitative addition of the liquid reagent.

[0057] The robotic arm 4 picks up the reaction bottle 13 containing the solid and / or liquid reagents and places it into the synthesis reaction module 11 for stirring reaction at a preset temperature. After the reaction is complete, the robotic arm 4 moves the reaction flask 13 back to its original position, connects it to an analytical instrument for testing, and outputs an experimental report. The control system activates the temperature control function of the reaction zone, adjusting each channel or independent temperature zone to the set temperature, and simultaneously starts the stirring module to stir the reaction system at the set speed. The temperature and stirring speed are fed back to the control system in real time to achieve closed-loop control and ensure stable reaction conditions.

[0058] In one embodiment, before reaching the synthesis reaction module 11, the robotic arm 4 grasps the reaction bottle 13 and places it into the pretreatment module 10 for vibration and / or gasification. If the experiment requires an anaerobic environment, the gasification module automatically introduces inert gas at a set flow rate and for a set time into the reaction bottle 13, removes air, and then closes the gas valve. Simultaneously, vibration shakes the solid raw materials adhering to the reaction bottle 13 into the bottle, ensuring accurate reaction between the solid and liquid raw materials. Vibration also serves as a preliminary mixing process between the solid and liquid raw materials.

[0059] In one embodiment, during the reaction process, the AI ​​video monitoring unit collects image data of the reaction area 2 in real time and processes the image data using an image recognition algorithm to automatically identify reagent leakage, container breakage, or abnormal reaction status. When an anomaly is detected or reaction parameters are found to exceed safety thresholds, the control system automatically triggers an alarm and executes a predetermined safety intervention procedure, which includes stopping heating, cutting off the power supply, and introducing inert gas.

[0060] In addition, during the experiment, users can pause the experiment through the control system, adjust parameters such as the feeding sequence, reaction temperature, and stirring speed, and then continue the experiment; they can also directly edit new experimental procedures in the system to achieve flexible switching of experimental procedures and meet the exploration needs of different reaction conditions.

[0061] The data management system records various parameters during the experiment in real time and generates experimental reports containing raw data and graphs, supporting export in PDF and Excel formats. The AI ​​model analyzes historical experimental data and automatically optimizes the parameter combinations for subsequent experiments to improve the success rate and efficiency of the reaction.

[0062] After the experiment is completed, the robotic arm 4 automatically transfers the reaction flask 13 from the reaction area to the sample storage area, or directly connects to the post-processing and analytical instruments through a standardized interface to realize automatic sample transfer and subsequent analysis without human intervention.

[0063] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A full-stack workstation for synthetic reactions, characterized in that, include: The main body of the workstation includes a workspace within which a synthetic reaction is performed. The workspace is equipped with a reaction area, a material preparation area, and a robotic arm. The robotic arm transports the reaction flasks that have been prepared in the material preparation area to the reaction area for synthesis reaction. The material preparation area includes a material preparation module, which comprises multiple solid raw material bottles, multiple liquid raw material bottles, and a consumable storage box; and A powder dispensing module, which can be used to place a solid raw material bottle at the feed inlet and quantitatively and accurately dispense fixed reagents into the reaction flask below; A liquid pipetting module is used to quantitatively aspirate liquid from the liquid raw material bottle and transfer it to the reaction bottle; The pretreatment module is used to add gas and shake the reaction flask. The synthesis reaction module has multiple reaction channels for temperature control and stirring of the reaction flask.

2. The full-stack synthetic reaction workstation according to claim 1, characterized in that, It also includes a barcode scanning and identification module. The solid raw material bottle, the liquid raw material bottle and the reaction bottle are all covered with a unique identification code. The barcode scanning and identification module is used to scan the unique identification code to obtain the identification information during sample transfer and reagent addition, and upload the identification information to the data management system.

3. The full-stack synthetic reaction workstation according to claim 1, characterized in that, It also includes a temperature monitoring module, which is used to monitor the temperature of the reaction area and the preparation area in real time.

4. The full-stack synthetic reaction workstation according to claim 1, characterized in that, It also includes a video monitoring module, which is used to monitor the abnormal status of the reaction area and the material preparation area in real time.

5. The full-stack synthetic reaction workstation according to claim 2, characterized in that, The data management system is used to record reaction parameters during the experiment and to export an experimental report after the reaction is completed.

6. The full-stack synthetic reaction workstation according to claim 1, characterized in that, The pretreatment module includes a shaking module and a gas-adding module. The shaking module is used to shake the reaction bottle containing the added solid and liquid raw materials, and the gas-adding module is used to introduce inert gas into the reaction bottle.

7. The full-stack synthetic reaction workstation according to claim 1, characterized in that, The synthesis reaction module includes multiple reaction zones, each with a different temperature range, and a heat insulation plate is provided between adjacent reaction zones.

8. A method of using the full-stack synthetic reaction workstation according to any one of claims 1-7, characterized in that, include: Receive the input experimental task parameters; The barcode scanning module reads the identification information of the solid raw material bottles and the liquid raw material bottles, and compares the identification information with the experimental task parameters; Place the reaction flasks into the feeding positions one by one; The robotic arm grasps the solid raw material bottle and installs it into the powder dispensing module, which quantitatively injects the solid reagent into the reaction bottle. The pipetting module draws a preset dose of liquid reagent from the liquid raw material bottle and injects it into the reaction bottle; The robotic arm picks up the reaction bottle containing the solid and / or liquid reagents and places it into the synthesis reaction module for a stirred reaction at a preset temperature; After the reaction is complete, the robotic arm moves the reaction flask back to its original position, connects it to an analytical instrument for testing, and outputs an experimental report.

9. The method of use according to claim 8, characterized in that, Before transferring the reaction flask to the synthesis reaction module, the robotic arm picks up the reaction flask and places it into the pretreatment module for oscillation and / or gas addition.

10. The method of use according to claim 8, characterized in that, During the reaction, the AI ​​video monitoring unit collects image data of the reaction area in real time and processes the image data using an image recognition algorithm to automatically identify reagent leakage, container breakage or abnormal reaction status. When an anomaly is detected or a reaction parameter exceeds a safety threshold, the control system automatically triggers an alarm and executes a predetermined safety intervention procedure.

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