Polymer hydrogel-based false tooth safety paste and preparation method thereof

Abstract

The invention relates to the technical field of oral care materials, and particularly discloses macromolecular hydrogel-based false tooth safety paste and a preparation method thereof. The macromolecular hydrogel-based denture safety paste is prepared from the following components in parts by weight: 10 to 20 parts of white oil, 20 to 40 parts of vaseline, 40 to 60 parts of polydopamine modified polyvinyl alcohol-based hydrogel, 20 to 40 parts of sodium carboxymethyl cellulose, 20 to 40 parts of methyl vinyl ether-maleic anhydride copolymer calcium sodium salt, 0.1 to 1 part of silicon dioxide, 0.1 to 1 part of 93 to 98 percent ethanol, 0.05 to 1 part of preservative, 0.1 to 2 parts of essence and 0.001 to 0.01 part of pigment. The polydopamine modified polyvinyl alcohol-based hydrogel is prepared from polyvinyl alcohol, dopamine hydrochloride, an activating agent, a coupling agent and poloxamer. According to the technical scheme provided by the invention, the prepared false tooth fixing paste has excellent properties of good bonding effect and strong durability.

Description

Technical Field

[0001] This application relates to the technical field of oral care materials, specifically to a polymer hydrogel-based denture adhesive and its preparation method. Background Technology

[0002] Currently, dentures often do not fit the oral cavity perfectly, resulting in instability and difficulties in chewing. Food debris can get into the gaps, fostering microbial growth and causing inconvenience for denture wearers, impacting hygiene and health. Denture adhesives, as auxiliary materials used to enhance the retention, stability, and function of dentures, have proven useful based on long-term practical experience.

[0003] Dental adhesive is a prosthetic product placed on the recessed surface (surface fit) of a removable denture to temporarily improve the stability of soft tissue. Ideally, a denture adhesive should be non-toxic, non-irritating to the oral mucosa, biocompatible, and not promote microbial growth. Furthermore, it should be odorless, tasteless, easy to use, and easily removed from the tissue-supporting surface of the denture.

[0004] Dental adhesives can be classified into the following types: Type 1: Adhesive type; whether in powder, paste, sheet, or thin film form, dental adhesives use water-soluble polymers as the adhesive component. Type 2: Lining type; Non-water-soluble prosthetic denture adhesives. Among them, Type 1 paste-like dental adhesives are called denture fixation pastes. Early denture fixation pastes made with plant-based gums were not very effective. Due to the high solubility of plant-based gums, they were easily washed away by saliva or water, thus having very limited effect on dentures. The main components of existing denture fixation pastes are sodium carboxymethyl cellulose and polymethyl vinyl ether-maleic anhydride copolymer (PVM-MA), etc. The application method is to squeeze out 1-2 cm of the product (visually estimated) and apply it to several concave areas. After application, seal the packaging tube immediately. Place the denture in the mouth and bite down 2-3 times to allow the product to fully spread and fill the gap between the denture and the mucosa, ensuring good denture retention. Sodium carboxymethyl cellulose alone has a strong initial retention capacity, absorbing water and swelling to fill gaps, and has a certain degree of adhesion. However, due to its high solubility, it dissolves rapidly and quickly loses its effectiveness, making it suitable for short-acting denture adhesives. It initially has strong filling and adhesion, but tends to fall off over time. PVM-MA salts alone have lower solubility, requiring a longer activation time to achieve a longer duration of action. Initially, adhesion is poor, reaching strong adhesion after several hours, but due to its water solubility, it also tends to fall off after a maximum of 8 hours.

[0005] Therefore, there is a need to provide a new type of denture fixation paste to achieve a stable and long-lasting effect. Summary of the Invention

[0006] To address the aforementioned technical problems, this application provides a polymer hydrogel-based denture adhesive and its preparation method.

[0007] This application provides a polymer hydrogel-based denture adhesive, specifically comprising the following components in parts by weight: 10-20 parts white oil, 20-40 parts petrolatum, 20-40 parts calcium sodium salt of methyl vinyl ether-maleic anhydride copolymer, 40-60 parts polydopamine-modified polyvinyl alcohol-based hydrogel, 20-40 parts sodium carboxymethyl cellulose, 0.1-1 parts silica, 0.1-1 parts 93-98% ethanol, 0.05-1 parts preservative, 0.1-2 parts fragrance, and 0.001-0.01 parts pigment; The polydopamine-modified polyvinyl alcohol-based hydrogel is prepared from polyvinyl alcohol, dopamine hydrochloride, activator 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, coupling agent N-hydroxysuccinimide, and poloxamer in a weight ratio of 22~30:7~15:0.1~1:0.1~1:1~3.

[0008] The polymer hydrogel-based denture stabilizing paste provided in this application uses white oil and petrolatum as the oil phase, providing an oily matrix and consistency; it contains hydrophilic phases such as polydopamine-modified polyvinyl alcohol-based hydrogel, sodium carboxymethyl cellulose, and calcium sodium salt of methyl vinyl ether-maleic anhydride copolymer. Poloxamer provides emulsification stabilization; its hydrophobic PPO segments can strongly adsorb or dissolve in the continuous oil phase (white oil / petrolatum); the hydrophilic PEO segments extend into and encapsulate the internal aqueous droplets, forming a tight adsorption layer; simultaneously, poloxamer molecules, through steric hindrance, prevent aqueous droplets from approaching and coalescing due to Brownian motion, thereby maintaining the long-term stability of the W / O emulsion. Silica particles in the continuous oil phase interact through hydrogen bonds and other means to form a stable structure, greatly increasing the viscosity and thixotropy of the oil phase itself, physically blocking the movement and coalescence of aqueous droplets, preventing the oil phase from floating / the aqueous phase from sinking. The polymer hydrogel-based denture adhesive provided in this application employs a three-component synergistic approach: polydopamine-modified polyvinyl alcohol hydrogel, methyl vinyl ether-maleic anhydride copolymer calcium and sodium salt, and sodium carboxymethyl cellulose. The polydopamine-modified polyvinyl alcohol hydrogel swells upon contact with water, forming a soft, highly elastic, and highly water-content gel that effectively fills the microscopic gaps between the denture base and the gingival tissue, acting as a mechanical sealant. Simultaneously, it forms a strong and lasting wet adhesion to mucin on the oral mucosa and the denture surface. Sodium carboxymethyl cellulose dissolves upon contact with water, significantly increasing local viscosity. Before the hydrogel fully swells, it rapidly forms a viscous barrier, providing initial adhesion and resistance to rinsing and drinking; it also keeps the gel moist and soft, preventing discomfort caused by drying and hardening due to dehydration. The methyl vinyl ether-maleic anhydride copolymer calcium and sodium salt contributes to a denser structure, significantly enhancing the gel's mechanical strength and cohesion, making it less prone to being washed away by saliva. The three components work synergistically: when the paste comes into contact with saliva, sodium carboxymethyl cellulose dissolves and thickens rapidly; polydopamine-modified polyvinyl alcohol-based hydrogel swells and forms a high-strength, water-resistant, specific adhesion with the mucosa / denture, constituting the main adhesion layer; methyl vinyl ether-maleic anhydride copolymer calcium sodium salt crosslinks under the action of saliva calcium ions, strengthening the entire gel network, improving the durability of anti-chewing, anti-erosion, and support, thereby achieving a stable effect that lasts for more than 8 hours.

[0009] Unmodified polyvinyl alcohol (PVA) hydrogels primarily bind to tissue surfaces through physical entanglement, hydrogen bonding, and weak van der Waals forces. In the moist oral environment, water molecules severely interfere with and weaken these forces, significantly reducing their adhesion. Furthermore, unmodified PVA hydrogels have limited affinity for hydrophobic acrylic resin denture surfaces. In contrast, the polydopamine-modified PVA hydrogel of this application utilizes EDC・HCl / NHS as an activation-coupling system to promote the amidation reaction between the amino groups of PVA and the hydroxyl groups of PVA, forming stable grafted chains and maintaining the gel state. This modification method introduces PVA, whose catechol groups can form various strong interactions with almost all solid surfaces, including: strong hydrogen bonding; metal coordination (allowing for the organization of trace metal ions in the oral environment or metal components on the denture surface); π-π stacking / cation-π interactions (interacting with biomolecules such as proteins and mucins); and Michael addition / Schiff base reactions (forming covalent bonds with the amino and thiol groups of proteins). In other words, polydopamine-modified polyvinyl alcohol-based hydrogel solves the problem of weak adhesion of traditional hydrogels in the moist environment of the oral cavity. Through multiple and powerful interfacial interactions, it achieves strong and long-lasting adhesion to biological tissues and denture materials, thus making the modified hydrogel a core component of high-performance denture adhesive.

[0010] Preferably, the polymer hydrogel-based denture adhesive is characterized by comprising the following components in parts by weight: 13-17 parts white oil, 25-35 parts petrolatum, 25-35 parts calcium sodium salt of methyl vinyl ether-maleic anhydride copolymer, 45-55 parts polydopamine-modified polyvinyl alcohol-based hydrogel, 25-35 parts sodium carboxymethyl cellulose, 0.3-0.7 parts silica, 0.3-0.7 parts 93-98% ethanol, 0.05-1 part preservative, 0.1-2 parts fragrance, and 0.001-0.01 parts pigment.

[0011] Preferably, the polydopamine-modified polyvinyl alcohol-based hydrogel is prepared from polyvinyl alcohol, dopamine hydrochloride, activator, coupling agent, and poloxamer in a weight ratio of 24~28:9~13:0.3~0.7:0.3~0.7:1.5~2.5.

[0012] Preferably, the preparation method of the polydopamine-modified polyvinyl alcohol-based hydrogel is as follows: 1-3 times the weight of ammonium persulfate initiator is added to a 5-15 wt% aqueous solution of dopamine hydrochloride, and the mixture is stirred to obtain a polydopamine solution; then a 20-40 wt% aqueous solution of polyvinyl alcohol is added, followed by an activator, coupling agent, and poloxamer, and the mixture is stirred evenly and heated to 35-50°C for a constant temperature reaction for 6-12 hours, ready for use.

[0013] Preferably, the degree of alcoholysis of the polyvinyl alcohol is 98.0~99.0 mol%, and the viscosity is 20.0~30.0 mPa·s.

[0014] Preferably, the reaction temperature is 40~45℃.

[0015] Preferably, the poloxamer is selected from any one or more of poloxamer 124, poloxamer 188, poloxamer 237, poloxamer 338, and poloxamer 407.

[0016] Preferably, the activator is 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; and the coupling agent is N-hydroxysuccinimide.

[0017] Preferably, the preservative is methylparaben; the flavoring is composed of menthol and peppermint oil in a weight ratio of 0.05~1:0.05~1; and the pigment is azorubin.

[0018] This application also provides a method for preparing the aforementioned polymer hydrogel-based denture adhesive, comprising the following steps: Mix white oil and petrolatum, heat to 60-80℃, and emulsify and stir. Add calcium sodium salt of methyl vinyl ether-maleic anhydride copolymer, and stir for 40-90 minutes. Add polydopamine-modified polyvinyl alcohol hydrogel, sodium carboxymethyl cellulose, and silica, and stir for 40-90 minutes. Then add 93-98% ethanol, preservatives, fragrance, and pigments, and vacuum to -0.07 to -0.09 MPa, and stir for 100-150 minutes. Then cool to 40-50℃, and fill and package to obtain the final product.

[0019] In summary, the technical solution of this application has the following effects: The polymer hydrogel-based denture adhesive prepared in this application has excellent properties such as good bonding effect and strong durability, which can effectively improve the retention and stability of complete dentures and improve the patient's denture use comfort. Detailed Implementation

[0020] The present application will be further described in detail below with reference to embodiments, comparative examples and performance test results. These embodiments should not be construed as limiting the scope of protection claimed in this application.

[0021] Example

[0022] Example 1 Example 1 provides a polymer hydrogel-based denture adhesive and its preparation method.

[0023] The preparation method of the polymer hydrogel-based denture adhesive in Example 1 is as follows: Preparation of polydopamine-modified polyvinyl alcohol-based hydrogel: 24g of ammonium persulfate initiator (twice the weight of dopamine hydrochloride) was added to a 10wt% dopamine hydrochloride aqueous solution (prepared by adding 12g dopamine hydrochloride to 108g water), and the mixture was stirred at 200rpm for 60min to obtain a polydopamine solution. Then, a 25wt% polyvinyl alcohol aqueous solution (prepared by adding 25g polyvinyl alcohol to 75g water) was added, followed by 0.5g of activator 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.5g of coupling agent N-hydroxysuccinimide, and 2g of poloxamer 338. The mixture was stirred at 2000rpm until homogeneous, and then heated to 42℃ for a constant temperature reaction for 8h. The gel was then ready for use. The weight ratio of polyvinyl alcohol (polyvinyl alcohol with a degree of hydrolysis of 98.0-99.0 mol% and a viscosity of 20.0-30.0 mPa·s), dopamine hydrochloride, activator, coupling agent, and poloxamer was 25:12:0.5:0.5:2. The polyvinyl alcohol was purchased from Shanghai Yuanye.

[0024] Preparation of Dental Prosthesis Firming Paste: Mix 15g white oil and 30g petrolatum, heat to 70℃, and emulsify and stir for 60min; add 30g methyl vinyl ether-maleic anhydride copolymer calcium sodium salt, and keep warm and stir for 60min; add 50g polydopamine-modified polyvinyl alcohol-based hydrogel, 30g sodium carboxymethyl cellulose, and 0.5g silica, and keep warm and stir for 60min; then add 0.5g 95% ethanol, 0.5g methylparaben (preservative), 1g fragrance (composed of menthol and peppermint oil in a 1:1 weight ratio), and 0.005g pigment azorubine; vacuum to -0.08Mpa, and keep warm and stir for 120min. Then cool to 40~50℃, fill and package to obtain the final product.

[0025] Examples 2-5 Examples 2-5 respectively provide a polymer hydrogel-based denture adhesive and its preparation method.

[0026] The specific differences between the above embodiments and Embodiment 1 are as follows: the amounts of polydopamine-modified polyvinyl alcohol-based hydrogel and sodium carboxymethyl cellulose are different, as shown below.

[0027] In Example 2: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel used was 55g, and the amount of sodium carboxymethyl cellulose used was 25g.

[0028] In Example 3: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel used was 45g, and the amount of sodium carboxymethyl cellulose used was 35g.

[0029] In Example 4: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel used was 40g, and the amount of sodium carboxymethyl cellulose used was 40g.

[0030] In Example 5: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel used was 60g, and the amount of sodium carboxymethyl cellulose used was 20g.

[0031] All other process parameters in the above embodiments are the same as those in Embodiment 1.

[0032] Examples 6-12 Examples 6-12 respectively provide a polymer hydrogel-based denture fixation paste and its preparation method.

[0033] The difference between the above embodiments and Embodiment 1 is that the preparation methods of the polydopamine-modified polyvinyl alcohol-based hydrogel are different, as detailed below.

[0034] In Example 6, the degree of alcoholysis of polyvinyl alcohol was 85.0~90.0 mol%, and the viscosity was 20.0~30.0 mPa·s.

[0035] In Example 7, the degree of alcoholysis of polyvinyl alcohol was 98.0~99.0 mol%, and the viscosity was 54.0~66.0 mPa·s.

[0036] In Example 8, the degree of alcoholysis of polyvinyl alcohol was 99.0~99.4 mol%, and the viscosity was 12.0~16.0 mPa·s.

[0037] In Example 9: In the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel, the weight ratio of polyvinyl alcohol (degree of alcoholysis of polyvinyl alcohol is 98.0~99.0 mol%, viscosity is 20.0~30.0 mPa.s), dopamine hydrochloride, activator, coupling agent and poloxamer is 22:15:0.5:0.5:2.

[0038] In Example 10: In the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel, the weight ratio of polyvinyl alcohol (degree of alcoholysis of polyvinyl alcohol is 98.0~99.0 mol%, viscosity is 20.0~30.0 mPa.s), dopamine hydrochloride, activator, coupling agent and poloxamer is 30:7:0.5:0.5:2.

[0039] In Example 11: In the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel, the weight ratio of polyvinyl alcohol (degree of alcoholysis of polyvinyl alcohol is 98.0~99.0 mol%, viscosity is 20.0~30.0 mPa.s), dopamine hydrochloride, activator, coupling agent and poloxamer is 24:13:0.5:0.5:2.

[0040] In Example 12: In the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel, the weight ratio of polyvinyl alcohol (degree of alcoholysis of polyvinyl alcohol is 98.0~99.0 mol%, viscosity is 20.0~30.0 mPa.s), dopamine hydrochloride, activator, coupling agent and poloxamer is 28:9:0.5:0.5:2.

[0041] All other process parameters in the above embodiments are the same as those in Embodiment 1.

[0042] Comparative Example Comparative Examples 1-5 Comparative Examples 1-5 each provide a denture fixation paste and its preparation method.

[0043] The difference between the above comparative examples and Example 1 is as shown in Table 1.

[0044] Comparative Example 1: No polydopamine-modified polyvinyl alcohol-based hydrogel was added.

[0045] In Comparative Example 2: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel was 30g, and the amount of sodium carboxymethyl cellulose was 50g.

[0046] In Comparative Example 3: the amount of polydopamine-modified polyvinyl alcohol-based hydrogel was 70g, and the amount of sodium carboxymethyl cellulose was 10g.

[0047] In Comparative Example 4: Polydopamine-modified gelatin-based hydrogel was used instead of polydopamine-modified polyvinyl alcohol-based hydrogel in equal amounts. The preparation method of polydopamine-modified gelatin-based hydrogel was as follows: 24g of ammonium persulfate initiator, twice the weight of dopamine hydrochloride, was added to a 10wt% dopamine hydrochloride aqueous solution (prepared by adding 12g of dopamine hydrochloride to 108g of water). The solution was stirred at 200rpm for 60min to obtain a polydopamine solution. Then, 25wt% gelatin (prepared by adding 25g of gelatin to 75g of water) was added, followed by 0.5g of activator 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.5g of coupling agent N-hydroxysuccinimide, and 2g of poloxamer 338. The mixture was stirred evenly and heated to 42℃ for constant temperature reaction for 8h. The solution was then ready for use. The weight ratio of gelatin, dopamine hydrochloride, activator, coupling agent, and poloxamer is 25:12:0.5:0.5:2.

[0048] In Comparative Example 5, the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel contained polyvinyl alcohol (with a degree of alcoholysis of 98.0-99.0 mol% and a viscosity of 20.0-30.0 mPa·s), dopamine hydrochloride, activator, coupling agent, and poloxamer in a weight ratio of 15:22:0.5:0.5:2.

[0049] All other process parameters in the above comparative examples are the same as those in Example 1.

[0050] Performance testing (1) Appearance: The denture adhesive prepared in this application presents as a uniformly colored oily paste at room temperature.

[0051] (2) Adhesion strength: Refer to ENISO 10873:2021 and use a servo material machine to test the sample; after soaking in a 37℃ water bath for 1 min and applying a 9.8N load for 30 s, record the maximum resistance of the pressure-sensitive shaft and calculate the adhesion strength per unit area. Repeat this test to obtain 3 test results for one sample and take the average value.

[0052] (3) Durability: Simulate the oral cavity environment, immerse in artificial saliva at 37°C (pH 6.8), apply an upward tension of 4.9N, connect a stress sensing device, record the stress change curve, and the time for the mold to separate and fall off.

[0053] (4) Biocompatibility (mucosal irritation): The experimental subjects were the alveolar mucosa of New Zealand white rabbits. 0.15g of denture adhesive was applied to the buccal pouch mucosa on one side of the animal, ensuring direct and continuous contact between the material and the mucosa for 6 hours. After removing the sample, the mucosal reaction was observed visually, and erythema and edema were scored: 0 points (none) to 4 points (severe). Five animals were tested in each group, and the average score was taken. The results were interpreted as follows: Average Irritation Index (PII) = (Total erythema score + Total edema score) / Number of animals; <0.5 indicates no irritation; 0.5-2.9 indicates mild irritation; 3.0-5.9 indicates moderate irritation; ≥6.0 indicates strong irritation.

[0054] (5) Cleanliness: A standard PMMA resin sheet, 2×2 cm in size, was used to simulate polished dentures. 10 mg of acetone paste was applied evenly to a 1×1 cm fixed area in the center of the substrate. The substrate with the sample was placed in an environment of 37°C and 95% relative humidity for 30 min to simulate intraoral curing; then it was immersed in artificial saliva (pH 6.8) at 37°C for 6 h to simulate wearing. Cleaning procedure: A standard electric toothbrush head was used and fixed on the testing instrument; cleaning medium: room temperature tap water. Parameters: pressure 150 g, frequency 2 Hz (simulating moderate brushing force), brushing back and forth for 30 seconds. After brushing, the substrate was rinsed with 50 mL of running water (simulating rinsing) for 10 s and dried at room temperature. Evaluation method: The mass difference of the substrate before and after cleaning was weighed using a precision balance, and the cleaning rate was calculated.

[0055] Test results are shown in Table 1.

[0056] Table 1. Performance test results of denture adhesive in the examples and comparative examples.

[0057] As can be seen from the test results in Table 1 above, the denture adhesive prepared using the technical solution provided in this application has high safety and excellent properties such as good bonding effect, strong durability and easy cleaning.

[0058] Comparing the test results of Examples 1-5 and Comparative Examples 1-3, it can be seen that the denture adhesive prepared in Comparative Example 1 without the addition of polydopamine-modified polyvinyl alcohol hydrogel, the amount of polydopamine-modified polyvinyl alcohol hydrogel in Comparative Example 2 being 30 parts and sodium carboxymethyl cellulose being 50 parts, and the amount of polydopamine-modified polyvinyl alcohol hydrogel in Comparative Example 3 being 70 parts and sodium carboxymethyl cellulose being 10 parts, resulted in poor performance. In contrast, the denture adhesive prepared in this application using 40-60 parts of polydopamine-modified polyvinyl alcohol hydrogel and 20-40 parts of sodium carboxymethyl cellulose as raw materials yields a denture adhesive with excellent performance.

[0059] Comparing the test results of Examples 1, 6-12, and Comparative Example 4, it can be seen that in Comparative Example 4, an equal amount of polydopamine-modified gelatin-based hydrogel was used instead of polydopamine-modified polyvinyl alcohol-based hydrogel. In Comparative Example 5, the preparation method of polydopamine-modified polyvinyl alcohol-based hydrogel used a weight ratio of polyvinyl alcohol, dopamine hydrochloride, activator, coupling agent, and poloxamer of 15:22:0.5:0.5:2, resulting in a denture adhesive with poor performance. In contrast, the present application uses polyvinyl alcohol, dopamine hydrochloride, activator, coupling agent, and poloxamer in a weight ratio of 22-30:7-15:0.1-1:0.1-1:1-3 to prepare polydopamine-modified polyvinyl alcohol-based hydrogel, resulting in a denture adhesive with excellent performance.

[0060] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A high molecular weight hydrogel-based denture adhesive paste, characterized in that, Specifically comprising the following components by weight: white oil 10-20 parts, vaseline 20-40 parts, methyl vinyl ether-maleic anhydride copolymer calcium sodium salt 20-40 parts, polydopamine modified polyvinyl alcohol-based hydrogel 40-60 parts, sodium carboxymethyl cellulose 20-40 parts, silicon dioxide 0.1-1 part, 93-98% ethanol 0.1-1 part, preservative 0.05-1 part, essence 0.1-2 parts, pigment 0.001-0.01 parts; The polydopamine modified polyvinyl alcohol-based hydrogel is prepared from polyvinyl alcohol, dopamine hydrochloride, activator 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, coupling agent N-hydroxysuccinimide, and poloxamer in a weight ratio of 22-30:7-15:0.1-1:0.1-1:1-3.

2. The polymeric hydrogel-based denture securing paste of claim 1, wherein Specifically comprising the following components by weight: white oil 13-17 parts, vaseline 25-35 parts, methyl vinyl ether-maleic anhydride copolymer calcium sodium salt 25-35 parts, polydopamine modified polyvinyl alcohol-based hydrogel 45-55 parts, sodium carboxymethyl cellulose 25-35 parts, silicon dioxide 0.3-0.7 parts, 93-98% ethanol 0.3-0.7 parts, preservative 0.05-1 part, essence 0.1-2 parts, pigment 0.001-0.01 parts.

3. The high polymer hydrogel base denture securing paste according to claim 1, wherein The polydopamine modified polyvinyl alcohol-based hydrogel is prepared from polyvinyl alcohol, dopamine hydrochloride, activator, coupling agent, and poloxamer in a weight ratio of 24-28:9-13:0.3-0.7:0.3-0.7:1.5-2.

5.

4. The high polymer hydrogel base denture securing paste according to claim 1, wherein The preparation method of the polydopamine modified polyvinyl alcohol-based hydrogel is as follows: adding initiator ammonium persulfate in an amount of 1-3 times the weight of dopamine hydrochloride to a dopamine hydrochloride aqueous solution with a concentration of 5-15 wt%, stirring to prepare a polydopamine solution; then adding a polyvinyl alcohol aqueous solution with a concentration of 20-40 wt%, then adding an activator, a coupling agent, and poloxamer, stirring uniformly, heating to 35-50°C for constant temperature reaction for 6-12 h, and then using.

5. The polymeric hydrogel-based denture securing paste of claim 4, wherein, The polyvinyl alcohol has an alcoholysis degree of 98.0-99.0 mol% and a viscosity of 20.0-30.0 mPa·s.

6. The polymeric hydrogel-based denture securing paste of claim 4, wherein the polymeric hydrogel-based denture securing paste is a polymeric hydrogel-based denture adhesive paste. The reaction temperature is 40-45°C.

7. The polymeric hydrogel-based denture securing paste of claim 1, wherein The poloxamer is selected from any one or more of poloxamer 124, poloxamer 188, poloxamer 237, poloxamer 338, and poloxamer 407.

8. The polymeric hydrogel-based denture securing paste of claim 1, wherein, The essence is composed of menthol and peppermint oil in a weight ratio of 0.05-1:0.05-1.

9. The polymeric hydrogel-based denture securing paste of claim 1, wherein, The preservative is nipagin methyl ester; and the pigment is azo carmine.

10. The method of claim 1 to 9, wherein the polymer hydrogel base denture adhesive is prepared by the steps of: The method comprises the following steps: Mix white oil and vaseline, heat to 60~80℃, emulsify and stir; add methyl vinyl ether-maleic anhydride copolymer calcium sodium salt, keep warm and stir for 40~90min; add polydopamine modified polyvinyl alcohol-based hydrogel, sodium carboxymethyl cellulose, and silicon dioxide, keep warm and stir for 40~90min; then add 93-98% ethanol, preservative, essence, and pigment, vacuumize to-0.07~-0.09Mpa, keep warm and stir for 100~150min; then cool to 40~50℃, fill and package, and the product is obtained.

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