Application of thermally inactivated bifidobacterium longum subsp. Infantis Y46 in promoting muscle development, delaying muscle atrophy and regulating cell functions

By using the heat-inactivated Bifidobacterium longum subsp. infantis Y46 preparation technology, the shortcomings of traditional therapies and the limitations of probiotics have been overcome, achieving safe and effective intervention for muscle development and atrophy, and significantly improving muscle function and cross-tissue regulation.

CN121668205APending Publication Date: 2026-03-17NORTHEAST AGRICULTURAL UNIVERSITY
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Patent Information

Application Number
CN202511656885.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-13
Publication Date
2026-03-17

AI Technical Summary

Technical Problem

Existing therapies have limited effectiveness against muscle atrophy and dysfunction, traditional drugs have significant side effects, there are many challenges in the storage and safety of live probiotics, the functions of inactivated bacteria have not been fully explored, and the intestinal-muscle axis and transtissue regulatory mechanisms are unclear.

Method used

Heat-inactivated Bifidobacterium longum subsp. infantis Y46 (HKY46) was prepared by culturing in a specific culture medium, centrifuging and washing, and heat treatment. It was then applied to the intervention of muscle development and muscle atrophy to regulate cell function.

Benefits of technology

It significantly promotes muscle development, delays muscle atrophy, reduces the accumulation of lipofuscin in Caenorhabditis elegans, improves motor ability, regulates the differentiation of nervous tissue and hematopoietic system, and provides a safe and effective biological agent strategy.

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Abstract

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the anti-aging aspect. The bifidobacterium longum subsp. Infantis Y46 is obtained from excrement of infants. Animal experiments prove that living cell thalli (Y46) and thermally inactivated cell thalli (HKY46) obtained by culturing the bifidobacterium longum subsp. Infantis Y46 by using an MRS liquid culture medium containing L-cysteine hydrochloride (0.05%, v / v) can significantly reduce accumulation of lipofuscin in a host, and prolong the healthy life and life of the host. Therefore, the bifidobacterium longum subsp. Infantis Y46 is a promising probiotic and a promising metagen with an anti-aging function.
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