Damp-proof L-alpha-glycerophosphatidylcholine

Abstract

According to the moistureproof L-alpha-glycerophosphatidylcholine and the preparation method thereof, by performing auxiliary material selection and preparation method treatment on the L-alpha-glycerophosphatidylcholine raw material, the problem that the L-alpha-glycerophosphatidylcholine is extremely strong in moisture absorption and deliquescence when exposed in air is solved, excellent moistureproof and deliquescence-resistant effects are achieved, and the stability of the L-alpha-glycerophosphatidylcholine is improved; and extremely high applicability is brought to a user.

Description

A moisture-proof L-α-glycerophosphatidylcholine Technical Field

[0001] The invention belongs to the technical field of dietary supplement preparations and relates to moisture-proof L-α-glycerophosphatidylcholine and a preparation method thereof. Background Art

[0002] L-α-glycerophosphatidylcholine (GPC), also known as glycerophosphorylcholine or choline glycerophosphate, is a product of the complete hydrolysis of the two fatty acyl groups on the phosphatidylcholine molecule. It is a naturally occurring water-soluble phospholipid precursor and neurotransmitter in the human body. GPC is a unique cell protectant that supports cell membrane fluidity and integrity. Years of experimental research and clinical application have demonstrated that GPC not only improves memory and cognitive abilities but also has significant therapeutic effects on cerebral circulatory decline and dementia-like conditions such as Alzheimer's disease, earning it the nickname "anti-aging nutrient" for the brain. Furthermore, it can combat muscle atrophy and protect blood vessels. Therefore, GPC holds significant research value in the dietary supplement and health care fields.

[0003] The molecular formula of L-α-glycerophosphatidylcholine is C8H 20 NO6P, with a relative molecular mass of 257.2, is a "dehexyl" phosphatidylcholine without a fatty acid tail. It carries both positive and negative charges, making it both hydrophilic and lipophilic. GPC is highly hygroscopic and soluble in water, methanol, and ethanol, but insoluble in other organic solvents. L-α-Glycerylphosphatidylcholine, a choline-like substance, is highly hygroscopic and deliquescent when exposed to air, resulting in poor stability. Applications often cause hygroscopic clumping and numerous instabilities. Therefore, the development of a moisture-resistant L-α-Glycerylphosphatidylcholine product is urgently needed to address this issue, and such a product would have a very broad market prospect.

[0004] Summary of the Invention

[0005] In order to solve the above problems, the present invention provides a moisture-proof L-α-glycerophosphatidylcholine and a preparation method thereof. By treating the L-α-glycerophosphatidylcholine raw material with a preparation method, the extremely strong moisture absorption and deliquescence of the raw material when exposed to the air is solved, thereby achieving excellent moisture-proof and deliquescence-resistant effects, improving the stability of the L-α-glycerophosphatidylcholine, bringing extremely high applicability to users, and achieving a high content that cannot be achieved by existing moisture-proof L-α-glycerophosphatidylcholine products on the market.

[0006] In one aspect, the present invention provides a moisture-proof L-α-glycerophosphatidylcholine comprising not less than 50% by weight of L-α-glycerophosphatidylcholine.

[0007] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises no less than 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50% L-α-glycerophosphatidylcholine by weight. In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises no less than 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 99% L-α-glycerophosphatidylcholine by weight. In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises 10-99%, 15-98%, 20-97%, 25-96%, 30-95%, 35-94%, 40-93%, 45-92%, 50-90% L-α-glycerophosphatidylcholine by weight. In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises 50-99%, 51-98%, 52-97%, 55-96%, 58-95%, 60-95%, 65-92%, 70-90% L-α-glycerophosphatidylcholine by weight.

[0008] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-99% of L-α-glycerophosphatidylcholine and 1-49% of one or more excipients selected from silicon dioxide, maltodextrin, mannitol, and silica gel.

[0009] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine further comprises 1-9% by weight of one or more excipients selected from hypromellose, lecithin or anhydrous sodium citrate.

[0010] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-91% L-α-glycerophosphatidylcholine; 1-41% one or more of silicon dioxide, maltodextrin, and mannitol; and 1-8% one or more of hypromellose, lecithin, or anhydrous sodium citrate.

[0011] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises 50-90% by weight of L-α-glycerophosphatidylcholine; 1-5% of one or more excipients selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micronized silica gel; 5-40% of one or more excipients selected from microcrystalline cellulose, compressible starch, lactose, or mannitol; and 1-9% of one or more excipients selected from hydroxypropyl methylcellulose, sodium alginate, gum arabic, and guar gum.

[0012] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 50-90% L-α-glycerophosphatidylcholine; 1-5% silicon dioxide; 5-40% microcrystalline cellulose; and 1-9% hypromellose.

[0013] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 50-80% L-α-glycerophosphatidylcholine; 1-5% silicon dioxide; 10-40% microcrystalline cellulose; and 4-9% hypromellose.

[0014] In some embodiments, the moisture-resistant L-α-glycerophosphatidylcholine is in granular or powdered form.

[0015] In some embodiments, the particle size of the moisture-resistant L-α-glycerophosphatidylcholine is 10-100 mesh. In some embodiments, the particle size of the moisture-resistant L-α-glycerophosphatidylcholine is 20-80 mesh.

[0016] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine is formulated as a nutritional supplement, food, beverage, or animal feed.

[0017] In some embodiments, the moisture-resistant L-α-glycerophosphatidylcholine is prepared as a solid preparation or a liquid preparation.

[0018] On the other hand, the present invention provides a method for preparing moisture-proof L-α-glycerophosphatidylcholine, comprising the following steps: preparing a formulated amount of hydroxypropyl methylcellulose into an ethanol solution; spraying the formulated amount of L-α-glycerophosphatidylcholine and one or more excipients selected from silicon dioxide, maltodextrin, mannitol, and silica gel to obtain an excipient spray material; and sieving and granulating to obtain moisture-proof L-α-glycerophosphatidylcholine.

[0019] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-99% of L-α-glycerophosphatidylcholine and 1-49% of one or more excipients selected from silicon dioxide, maltodextrin, mannitol, and silica gel.

[0020] In some embodiments, the method further comprises preparing a formulated amount of one or more excipients selected from lecithin or anhydrous sodium citrate into an ethanol solution before sieving and granulating, and spraying the excipient spray material.

[0021] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-91% L-α-glycerophosphatidylcholine; 1-41% one or more of silicon dioxide, maltodextrin, and mannitol; and 1-8% one or more of hypromellose, lecithin, or anhydrous sodium citrate.

[0022] In some embodiments, the spraying is one of top spraying, side spraying, or bottom spraying.

[0023] On the other hand, the present invention provides a method for preparing moisture-proof L-α-glycerophosphatidylcholine, comprising the following steps: mixing the following components according to the formula amount: L-α-glycerophosphatidylcholine, one or more excipients selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micropowdered silica gel, one or more excipients selected from microcrystalline cellulose, compressible starch, lactose, or mannitol, and one or more excipients selected from hydroxypropyl methylcellulose, sodium alginate, gum arabic, and guar gum; granulating after mixing; and sieving to obtain moisture-proof L-α-glycerophosphatidylcholine.

[0024] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 50-90% L-α-glycerophosphatidylcholine; 1-5% silicon dioxide; 5-40% microcrystalline cellulose; and 1-9% hypromellose.

[0025] In some embodiments, the granulation is one of wet granulation, fluidized bed granulation, spray granulation, melt granulation, and dry granulation.

[0026] In some embodiments, the granulation is dry granulation.

[0027] In some embodiments, the moisture-proof L-α-glycerophosphatidylcholine prepared by the above method is used to prepare food, beverage, nutrition product, skin care product or cosmetic.

[0028] This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description. This Summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter. DETAILED DESCRIPTION

[0029] The preferred embodiments of the present invention will now be described in detail with reference to the embodiments thereof. Although the present invention will be described in conjunction with the preferred embodiments, it should be understood that they are not intended to limit the present invention to these embodiments. On the contrary, the present invention is intended to cover substitutions, modifications and equivalents, which may be included within the spirit and scope of the present invention as defined in the claims.

[0030] As used herein, the term "or" is intended to include "and" and "or." In other words, the term "or" can also be replaced with "and / or."

[0031] As used herein, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0032] As used herein, the term "comprises" or "includes" or variations thereof refers to instances where the term is used in its non-limiting sense, meaning that items following the term are included, but items not specifically mentioned are not excluded. It also includes the more restrictive verbs 'consisting essentially of' and 'consisting of.'

[0033] Example

[0034] In the present invention, unless otherwise specified, the scientific and technical terms used herein have the meanings commonly understood by those skilled in the art. In addition, the laboratory procedures used herein are all conventional procedures widely used in the relevant fields.

[0035] Unless otherwise specified, the raw materials and reagents used in the present invention are commercially available. All reagents are of commercial grade and used according to the standards received.

[0036] In one aspect, the present invention provides a moisture-resistant L-α-glycerophosphatidylcholine. The moisture-resistant L-α-glycerophosphatidylcholine of the present invention has excellent moisture and deliquescence resistance, improves the stability of the L-α-glycerophosphatidylcholine, and provides users with extremely high applicability. The L-α-glycerophosphatidylcholine used in the present invention can be prepared and obtained by known methods.

[0037] On the other hand, the present invention provides a method for preparing moisture-proof L-α-glycerophosphatidylcholine. The present invention screens the granulation method of the GPC raw material, and can adopt a fluidized bed method for granulation. The fluidized bed granulation spray adopts three granulation methods: top spray, side spray and bottom spray, and top spray granulation is preferred. The fluidized bed method adopted by the present invention for the selected excipients is used to granulate L-α-glycerophosphatidylcholine, which can achieve mixing, granulation and drying in one step. The production process is simple and the degree of automation is high. The obtained product is round, uniform and has good solubility. In this method, one or more excipients selected from microcrystalline cellulose, compressible starch, lactose or mannitol, and one or more excipients selected from hydroxypropyl methylcellulose, sodium alginate, gum arabic, guar gum, lecithin or anhydrous sodium citrate can be respectively prepared into an ethanol solution with a solid content of 5%, and the L-α-glycerophosphatidylcholine is sprayed. The moisture-proof L-α-glycerophosphatidylcholine can be obtained by sieving the pellets through a 10-100 mesh, preferably a 20-80 mesh, sieve. In this method, mannitol and the like have excellent anti-hygroscopic, anti-caking, and anti-sticking effects; and coating materials such as hydropropyl methylcellulose can achieve an anti-hygroscopic effect by blocking moisture.

[0038] In addition, the present invention can screen the granulation methods of GPC raw materials, such as wet granulation, fluidized bed granulation, spray granulation, melt granulation, and dry granulation, and preferably granulate by dry granulation; the dry granulation process used is applicable to the formula of the present invention and will not cause bed collapse, the process energy consumption is small, the production cost is low, and there is no solvent intervention in the preparation process. The production process is green and environmentally friendly, and no waste gas and wastewater are generated. The addition of microcrystalline cellulose and the like in this formula can achieve a good anti-caking effect, and the use of hydroxypropyl methylcellulose and the like contributes to the further preparation application of moisture-proof L-α-glycerophosphatidylcholine. Silicon dioxide and the like have good anti-caking and anti-sticking effects. The combination of these three materials has the advantages of high production yield, significant anti-hygroscopic effect, and economical and easily available auxiliary materials. This method can select 10-100 mesh, preferably 20-80 mesh sieve to obtain moisture-proof L-α-glycerophosphatidylcholine.

[0039] This method achieves the preparation of high-content moisture-proof L-α-glycerophosphatidylcholine through the screening of suitable excipients and granulation methods. The prepared moisture-proof L-α-glycerophosphatidylcholine achieves excellent moisture-proof and deliquescence-resistant effects, improves the stability of L-α-glycerophosphatidylcholine, and provides users with extremely high applicability.

[0040] The following examples are illustrative of selected embodiments of the present invention and are not intended to limit the scope of the invention.

[0041] Example 1 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0042] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0043] The preparation method is as follows: a prescribed amount of hypromellose is prepared into a 5% solids ethanol solution. The prescribed amount of L-α-glycerophosphatidylcholine, maltodextrin, and silicon dioxide are sprayed onto the solution. After granulation, the granules are sieved through a 40-mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0044] Example 2 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0045] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0046] The preparation method is as follows: a prescribed amount of hypromellose is prepared into a 5% solids ethanol solution. The prescribed amount of L-α-glycerophosphatidylcholine, maltodextrin, and silicon dioxide are sprayed onto the solution. After granulation, the granules are sieved through a 40-mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0047] Example 3 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0048] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0049] The preparation method is as follows: The prescribed amount of hypromellose is prepared into a 5% solids ethanol solution. The prescribed amount of L-α-glycerophosphatidylcholine, maltodextrin, and silicon dioxide are sprayed. After granulation, the granules are passed through a 40-mesh sieve to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0050] Example 4 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0051] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0052] The preparation method is as follows: The prescribed amount of hypromellose and lecithin are each prepared into a 5% solids ethanol solution. The prescribed amount of L-α-glycerophosphatidylcholine, mannitol, and silicon dioxide are sprayed sequentially with the ethanol solution. After granulation, the granules are passed through a 40-mesh sieve to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0053] Example 5 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0054] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0055] The preparation method is as follows: a prescribed amount of hypromellose and anhydrous sodium citrate are prepared into an ethanol solution having a 5% solids content. The prescribed amount of L-α-glycerophosphatidylcholine and silicon dioxide are sprayed sequentially with the ethanol solution. After granulation, the granules are passed through a 40-mesh sieve to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0056] Example 6 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0057] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0058] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0059] Example 7 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0060] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0061] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0062] Example 8 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0063] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0064] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0065] Example 9 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0066] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0067] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0068] Example 10 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0069] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0070] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0071] Example 11 Preparation of moisture-proof L-α-glycerophosphatidylcholine

[0072] A moisture-proof L-α-glycerophosphatidylcholine comprises the following components in percentage by weight:

[0073] The preparation method is as follows: L-α-glycerophosphatidylcholine, microcrystalline cellulose, hypromellose, and silicon dioxide are sieved separately and then uniformly mixed according to the above-mentioned formula. After uniform mixing, dry granulation is performed to prepare intermediate moisture-resistant L-α-glycerophosphatidylcholine at a feed speed of 5-10 rpm, a roller pressure of 5 MPa, a tableting pressure of 5-25 MPa, and a granulation speed of 10 rpm. The granules are then sieved through a 20-80 mesh screen to obtain moisture-resistant L-α-glycerophosphatidylcholine.

[0074] Example 12: Investigation of the Moisture-Proof L-α-Glycerylphosphatidylcholine Moisture-Proofing Property

[0075] Specific test method: Place a dry, stoppered glass weighing bottle (50 mm outer diameter, 15 mm height) in a climate chamber (set temperature at 25°C, relative humidity at 75%) the day before the test and accurately weigh (m1). Spread an appropriate amount of the test sample evenly in the bottle, typically about 1 mm thick, and accurately weigh (m2). Uncover the bottle and place it under the same constant temperature and humidity conditions as described above. Remove the bottle after 5, 10, 20, 30, 60, 120, and 180 minutes and accurately weigh (m3). Calculate the percent weight gain using the formula: Percent weight gain = 100% × (m3 - m2) / (m2 - m1). The results of moisture-resistant L-α-glycerophosphatidylcholine hygroscopic weight gain are shown in Table 1.

[0076] Table 1

[0077] As shown in Table 1, the moisture-proof L-α-glycerophosphatidylcholine prepared by the present invention has a significantly better moisture-proof and anti-hygroscopic deliquescence effect than both the raw material and the commercially available finished product under high humidity conditions. Furthermore, the moisture-proof effect becomes more pronounced as the amount of excipients increases. The moisture-proof L-α-glycerophosphatidylcholine prepared by the present invention can achieve a more significant moisture-proof and anti-hygroscopic deliquescence effect than both the raw material and the commercially available finished product under high humidity conditions when it contains no less than 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, or 99% by weight of L-α-glycerophosphatidylcholine.

[0078] Example 17 Comparative Study on the Fluidity, Adhesion and Deliquescence of Moisture-Proof L-α-Glycerylphosphatidylcholine in an Artificial Climate Box (Set Temperature at 25°C, Relative Humidity at 75%)

[0079] Evaluation criteria: Weigh 5g of material into a weighing dish (60*30mm), place it open at 25°C / 75% RH, and observe the moisture-proof effect for 0-3 hours. The fluidity results of moisture-proof L-α-glycerophosphatidylcholine of some examples are shown in Table 2.

[0080] Table 2

[0081] As can be seen from Table 2 above, the moisture-proof L-α-glycerophosphatidylcholine prepared by the disclosed method has better moisture resistance and good fluidity than the raw material and commercial samples under high humidity conditions while having a high loading capacity. The products prepared in Examples 3, 4, and 5 achieved the maximum loading capacity of L-α-glycerophosphatidylcholine while having good moisture resistance.

[0082] The scoring criteria for some examples are shown in Table 3-1. The scoring results of the fluidity, adhesion, and deliquescent properties of moisture-proof L-α-glycerophosphatidylcholine are shown in Table 3-2.

[0083] Table 3-1

[0084] Table 3-2

[0085] It can be seen from Table 3-2 that the moisture-proof L-α-glycerophosphatidylcholine prepared by the present invention has higher fluidity, adhesion (agglomeration) and deliquescence scores under high humidity conditions than the raw materials and commercially available finished products. Moreover, as the amount of excipients increases, the fluidity, anti-adhesion and deliquescence resistance become better.

[0086] Although specific embodiments and examples of the present invention have been described herein, it will be understood by those skilled in the art that any modifications and variations may be made without departing from the principles of the present invention. The above examples and descriptions do not limit the scope of the present invention. Any combination of the embodiments of the present invention, as well as any obvious extensions or analogs thereof, are within the scope of the present invention. Furthermore, the present invention encompasses any arrangement intended to achieve the same purpose, as well as all such variations and modifications that fall within the scope of the appended claims.

Claims

1. A moisture-proof L-α-glycerophosphatidylcholine, characterized in that: Contains not less than 50% by weight of L-α-glycerophosphatidylcholine.

2. The moisture-proof L-α-glycerophosphatidylcholine according to claim 1, characterized in that Containing not less than 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60% by weight of L-α-glycerophosphatidylcholine.

3. The moisture-proof L-α-glycerophosphatidylcholine according to claim 1 or 2, characterized in that: The invention comprises 51-99% by weight of L-α-glycerophosphatidylcholine and 1-49% by weight of one or more auxiliary materials selected from silicon dioxide, maltodextrin, mannitol and silica gel.

4. The moisture-proof L-α-glycerophosphatidylcholine according to any one of claims 1 to 3, characterized in that The invention also contains 1-9% by weight of one or more auxiliary materials selected from hydroxypropyl methylcellulose, lecithin or anhydrous sodium citrate.

5. The moisture-proof L-α-glycerophosphatidylcholine according to any one of claims 1 to 4, characterized in that The invention comprises 51-91% by weight of L-α-glycerophosphatidylcholine; 1-41% of one or more of silicon dioxide, maltodextrin and mannitol; and 1-8% of one or more of hydroxypropyl methylcellulose, lecithin or anhydrous sodium citrate.

6. The moisture-proof L-α-glycerophosphatidylcholine according to claim 1 or 2, characterized in that: The invention comprises 50-90% by weight of L-α-glycerophosphatidylcholine; 1-5% of one or more auxiliary materials selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micro-powdered silica gel; 5-40% of one or more auxiliary materials selected from microcrystalline cellulose, compressible starch, lactose, or mannitol; and 1-9% of one or more auxiliary materials selected from hydroxypropyl methylcellulose, sodium alginate, gum arabic, and guar gum.

7. The moisture-proof L-α-glycerophosphatidylcholine according to claim 1, 2 or 6, characterized in that: The invention comprises 50-90% by weight of L-α-glycerophosphatidylcholine; 1-5% by weight of silicon dioxide; 5-40% by weight of microcrystalline cellulose; and 1-9% by weight of hypromellose.

8. The moisture-proof L-α-glycerophosphatidylcholine according to claim 1, 2, 6 or 7, characterized in that: The invention comprises 50-80% L-α-glycerophosphatidylcholine, 1-5% silicon dioxide, 10-40% microcrystalline cellulose, and 4-9% hypromellose by weight.

9. The moisture-proof L-α-glycerophosphatidylcholine according to any one of claims 1 to 8, characterized in that The moisture-proof L-α-glycerophosphatidylcholine is in the form of granules or powder.

10. The moisture-proof L-α-glycerophosphatidylcholine according to claim 9, characterized in that: The particle size of the moisture-proof L-α-glycerophosphatidylcholine is 10-100 meshes.

11. The moisture-proof L-α-glycerophosphatidylcholine according to any one of claims 1 to 10, characterized in that The moisture-proof L-α-glycerophosphatidylcholine is formulated into a nutritional supplement, food, beverage or animal feed.

12. The moisture-proof L-α-glycerophosphatidylcholine according to any one of claims 1 to 11, characterized in that The moisture-proof L-α-glycerophosphatidylcholine is prepared as a solid preparation or a liquid preparation.

13. A method for preparing moisture-proof L-α-glycerophosphatidylcholine, characterized in that: The method comprises the following steps: preparing a formula amount of hydroxypropyl methylcellulose into an ethanol solution; spraying a formula amount of L-α-glycerophosphatidylcholine and one or more auxiliary materials selected from silicon dioxide, maltodextrin, mannitol and silica gel to obtain auxiliary material spraying material; and sieving and granulating to obtain the moisture-proof L-α-glycerophosphatidylcholine.

14. The method according to claim 13, characterized in that The moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-99% of L-α-glycerophosphatidylcholine and 1-49% of one or more auxiliary materials selected from silicon dioxide, maltodextrin, mannitol and silica gel.

15. The method according to claim 13 or 14, characterized in that The method also includes preparing a formula amount of one or more auxiliary materials selected from lecithin or anhydrous sodium citrate into an ethanol solution before sieving and granulating, and spraying the auxiliary material spray material.

16. The method according to claim 15, characterized in that The moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 51-91% of L-α-glycerophosphatidylcholine; 1-41% of one or more of silicon dioxide, maltodextrin, and mannitol; and 1-8% of one or more of hydroxypropyl methylcellulose, lecithin, or anhydrous sodium citrate.

17. The method according to any one of claims 13 to 16, characterized in that The spraying is one of top spraying, side spraying or bottom spraying.

18. A method for preparing moisture-proof L-α-glycerophosphatidylcholine, characterized in that: The following steps are involved: The following components are mixed according to the formula amount: L-α-glycerophosphatidylcholine, one or more auxiliary materials selected from silicon dioxide, magnesium stearate, calcium hydrogen phosphate, calcium silicate, and micro-powder silica gel, one or more auxiliary materials selected from microcrystalline cellulose, compressible starch, lactose or mannitol, and one or more auxiliary materials selected from hydroxypropyl methylcellulose, sodium alginate, gum arabic, and guar gum; granulation is performed after mixing; and sieving is performed to obtain the moisture-proof L-α-glycerophosphatidylcholine.

19. The method according to claim 18, characterized in that The moisture-proof L-α-glycerophosphatidylcholine comprises, by weight, 50-90% of L-α-glycerophosphatidylcholine, 1-5% of silicon dioxide, 5-40% of microcrystalline cellulose, and 1-9% of hydroxypropyl methylcellulose.

20. The method according to claim 18 or 19, characterized in that The granulation is one of wet granulation, fluidized bed granulation, spray granulation, melt granulation and dry granulation.

21. The method according to claim 20, characterized in that The granulation is dry granulation.

22. The method according to any one of claims 13 to 21, characterized in that The moisture-proof L-α-glycerophosphatidylcholine prepared by the method is used for preparing food, beverage, nutrition product, skin care product or cosmetic.