Composite bactericide of nanoscale silver ions and traditional Chinese medicine extract

By using a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts, the problems of poor efficacy and irritation of existing bactericides have been solved, achieving highly efficient killing of a variety of bacteria and environmental friendliness, while improving preparation efficiency.

CN121694334APending Publication Date: 2026-03-20JIANGSU JINSHIDUN PHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202411305561.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-19
Publication Date
2026-03-20

AI Technical Summary

Technical Problem

Existing bactericides have a single ingredient composition, are not effective against some bacteria and viruses, and some chemical components are irritating to the skin. They are also inefficient and may pollute the environment.

Method used

A composite bactericide using nano-sized silver ions and traditional Chinese medicine extracts, including Sophora flavescens, Phellodendron chinense, Smilax glabra, Cnidium monnieri, Artemisia capillaris, Lonicera japonica, and silver ions, is prepared by mixing them through a specific method to form silver ions in the form of an aqueous solution. This is then rapidly mixed using a traditional Chinese medicine extraction mechanism and a stirring tank.

Benefits of technology

It achieves highly efficient killing of Vibrio, mold, Aeromonas hydrophila, Escherichia coli, etc., with high cost performance, gentle and non-irritating to the skin, environmentally friendly and pollution-free, and improved preparation efficiency.

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Abstract

The invention discloses a nano-scale silver ion and traditional Chinese medicine extract composite bactericide, and relates to the technical field of composite bactericides, the nano-scale silver ion and traditional Chinese medicine extract composite bactericide comprises 30 g of sophora flavescens, 10 g of phellodendron, 30 g of glabrous greenbrier rhizome, 15 g of common cnidium fruit, 10 g of oriental wormwood, 10 g of honeysuckle, and 20 g of silver ions with a silver content of 5000 ppm, and 1000 ml of the nano-scale silver ion and traditional Chinese medicine extract composite bactericide is prepared. Silver ions are positively charged cations formed when metal silver loses one or more electrons and comprise Ag < 1 + >, Ag < 2 + > and Ag < 3 + > which exist in the form of an aqueous solution, and the preparation method of the nano-scale silver ion and traditional Chinese medicine extract composite bactericide comprises the following steps that S1, six traditional Chinese medicines including radix sophorae flavescentis, cortex phellodendri, rhizoma smilacis glabrae, fructus cnidii, herba artemisiae scopariae and honeysuckle flowers are taken and extracted with water for use. The traditional Chinese medicine composition has a good killing effect on vibrio, mould, aeromonas hydrophila and the like through the combination of the traditional Chinese medicine and the silver ions, compared with a single preparation, the dosage of the traditional Chinese medicine composition is better than that of a single preparation, and the traditional Chinese medicine composition is better in killing bacteria and inhibiting drug resistance of viruses and is higher in cost performance.
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Description

Technical Field

[0001] This invention relates to the field of compound bactericide technology, specifically to a compound bactericide of nano-sized silver ions and traditional Chinese medicine extracts. Background Technology

[0002] Medical disinfectants are chemical substances used to kill or eliminate microorganisms on the surfaces of hospital environments, medical devices, surgical instruments, wounds, and skin infections. These disinfectants typically possess broad-spectrum, high-efficiency, low-toxicity, and non-irritating characteristics, effectively killing various bacteria, viruses, fungi, and other microorganisms, thereby ensuring medical safety and patient health. However, existing technologies have the following problems: Because existing bactericides have relatively simple ingredients, they cannot effectively kill some bacteria and viruses, resulting in low cost-effectiveness. Furthermore, the chemical components in some bactericides can irritate people with sensitive skin, and these chemical components may also pollute the environment. Summary of the Invention

[0003] This invention provides a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts to solve the problems mentioned in the background art.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: A composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts, comprising: Sophora flavescens: 30g, Phellodendron chinense: 10g, Smilax glabra: 30g, Cnidium monnieri: 15g, Artemisia capillaris: 10g, Lonicera japonica: 10g, and silver ions with a silver content of 5000ppm: 20g, prepared into 1000ml. Silver ions are positively charged cations formed by metallic silver losing one or more electrons, including Ag1+, Ag2+, and Ag3+, and exist in the form of an aqueous solution.

[0005] A further improvement to the technical solution of this invention lies in: a method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts, characterized by comprising the following steps: S1: Take six kinds of Chinese herbs, namely Sophora flavescens, Phellodendron chinense, Smilax glabra, Cnidium monnieri, Artemisia capillaris, and Lonicera japonica, and extract them with water for later use; S2: Add nano-sized silver ions to the traditional Chinese medicine extract and stir to mix; S3: Continue to add the Chinese herbal extract to the mixture in S2, mix and stir, and test the content indicators.

[0006] A further improvement of the technical solution of the present invention is that: after taking the six Chinese medicines in S1, water needs to be added twice for extraction, with the amount of water added being 10 times and 8 times respectively, and the extraction time being 2 hours and 1 hour respectively. The filtrates are combined and concentrated to a relative density between 1.18 and 1.22, and then filtered for later use.

[0007] A further improvement to the technical solution of the present invention is that: in step S2, nano-sized silver ions need to be added to the traditional Chinese medicine extract in step S1 at an addition amount of 2%, and stirred continuously for 10 minutes, and purified water needs to be added in time.

[0008] A further improvement to the technical solution of the present invention is that: in step S3, 10 kg of baicalin and 10 kg of chlorogenic acid, the traditional Chinese medicine extracts from step S1, are added successively and stirred for 15 minutes. Samples are taken to check the solubility. After complete dissolution, the content indicators are tested, and the test indicators are silver ions: ≥100ppm and alkaloids: ≥0.1%.

[0009] A further improvement to the technical solution of this invention is as follows: A compound bactericide mixing device is proposed, comprising a traditional Chinese medicine extraction mechanism and a mixing tank. The traditional Chinese medicine extraction mechanism is located on the left side of the mixing tank. The traditional Chinese medicine extraction mechanism includes a base plate. A lifting column and an inverted J-shaped bracket are fixedly installed on the top left side of the base plate. The vertical part of the inverted J-shaped bracket is located on the left side of the lifting column. A sliding groove is opened on the right side of the lifting column. An upgraded drive motor is fixedly installed on the top of the lifting column. The output shaft of the upgraded drive motor passes through the inner cavity of the sliding groove and is fixedly installed with a threaded rod. A lifting plate is threaded on the outer wall of the threaded rod. The traditional Chinese medicine extraction tank is fixedly installed on the right end of the lifting plate.

[0010] A further improvement of the technical solution of the present invention is that: a circular filter screen for traditional Chinese medicine is fixedly installed at the bottom of the right vertical position of the inverted J-shaped bracket; the outer wall of the circular filter screen overlaps with the inner wall of the traditional Chinese medicine extraction tank; an L-shaped drain pipe is fixedly connected through the bottom of the traditional Chinese medicine extraction tank; an electric control valve is fixedly installed on the outer wall of the L-shaped drain pipe; a drain pipe groove is opened at the top of the base plate; and the L-shaped drain pipe and the electric control valve are both located inside the drain pipe groove after the traditional Chinese medicine extraction tank is lowered.

[0011] A further improvement of the technical solution of the present invention is as follows: a liquid pump is fixedly installed on the top left side of the mixing tank, a connecting hose is fixedly connected to the input end of the liquid pump, the left input end of the connecting hose is fixedly connected to the right end of the L-shaped drain pipe, the output end of the liquid pump extends through the inner cavity of the mixing tank, a traditional Chinese medicine extract addition port is fixedly connected to the top rear side of the mixing tank, a silver ion addition tube is fixedly connected to the top right side of the mixing tank, a stirring motor is fixedly installed at the bottom center of the mixing tank, the output shaft of the stirring motor extends through the inner cavity of the mixing tank and a rotating rod is fixedly installed thereon, blades are evenly fixedly installed on the upper part of the outer wall of the rotating rod, a plurality of stirring rods are evenly fixedly installed on the lower part of the outer wall of the rotating rod, and a liquid outlet pipe is fixedly connected to the lower right side of the mixing tank.

[0012] Due to the adoption of the above technical solution, the technical progress achieved by this invention compared to the prior art is as follows: This invention provides a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts. Through the dual effect of traditional Chinese medicine and silver ions, it has a good killing effect on Vibrio, mold, Aeromonas hydrophila, Escherichia coli and other bacteria. Compared with single preparations, it is superior in terms of dosage, killing of bacteria and inhibiting drug resistance of viruses, and has a higher cost performance.

[0013] This invention provides a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts. By combining all traditional Chinese medicine ingredients with silver ions, the resulting composite bactericide has the advantages of being gentle and non-irritating to human skin, and being environmentally friendly and pollution-free.

[0014] This invention provides a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts. Through the cooperation between the traditional Chinese medicine extraction mechanism and the stirring tank, the traditional Chinese medicine extraction mechanism can quickly separate the traditional Chinese medicine extract and the extract liquid during the preparation of the bactericide, and at the same time quickly mix it with nano-sized silver ions, thereby reducing the preparation process, speeding up the mixing speed, and thus improving the preparation efficiency. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the preparation method of the present invention; Figure 2 This is a schematic diagram of the compound bactericide mixing device of the present invention; Figure 3 This is a schematic diagram of the herbal medicine extraction mechanism of the present invention; Figure 4 This is a schematic diagram of the descent of the herbal medicine extraction tank of the present invention; Figure 5 This is a schematic cross-sectional view of the mixing tank of the present invention.

[0016] In the diagram: 1. Herbal extraction mechanism; 11. Base plate; 111. Drainage pipe groove; 12. Lifting column; 13. Slide groove; 14. Upgraded drive motor; 15. Threaded rod; 16. Lifting plate; 17. Herbal extraction tank; 171. L-shaped drainage pipe; 172. Electrically controlled valve; 18. Inverted J-shaped bracket; 181. Circular herbal filter screen; 2. Stirring tank; 21. Liquid pump; 211. Connecting hose; 22. Herbal extract addition port; 23. Silver ion addition pipe; 24. Stirring motor; 241. Rotating rod; 242. Blade; 243. Stirring rod; 25. Discharge pipe. Detailed Implementation

[0017] The present invention will be further described in detail below with reference to embodiments: Example

[0018] like Figure 1-5As shown, this invention provides a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts. The ingredients include: Sophora flavescens: 30g, Phellodendron chinense: 10g, Smilax glabra: 30g, Cnidium monnieri: 15g, Artemisia capillaris: 10g, Lonicera japonica: 10g, and silver ions with a silver content of 5000ppm: 20g. The mixture is prepared into 1000ml. Silver ions are positively charged cations formed by metallic silver losing one or more electrons, including Ag1+, Ag2+, and Ag3+, and exist in the form of an aqueous solution. Example

[0019] like Figure 1-5 As shown in Example 1, this invention provides a method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts: preferably, it includes the following steps: S1: Take six kinds of Chinese herbs, namely Sophora flavescens, Phellodendron chinense, Smilax glabra, Cnidium monnieri, Artemisia capillaris, and Lonicera japonica, and extract them with water for later use; S2: Add nano-sized silver ions to the traditional Chinese medicine extract and stir to mix; S3: Continue to add the Chinese herbal extract to the mixture in S2, mix and stir, and test the content indicators; After extracting the six Chinese herbs in S1, water needs to be added twice, with the water volume being 10 times and 8 times respectively, and the extraction time being 2 hours and 1 hour respectively. The filtrates are combined and concentrated to a relative density between 1.18 and 1.22. After filtration, they are set aside. In S2, nano-sized silver ions are added to the Chinese herbal extract from S1 at a dosage of 2%, and stirred continuously for 10 minutes. Purified water needs to be added in time. In S3, 10 kg of baicalin and 10 kg of chlorogenic acid, the Chinese herbal extracts from S1, are added successively and stirred for 15 minutes. Samples are taken to check the solubility. After complete dissolution, the content indicators are tested, with the test indicators being silver ions: ≥100 ppm and alkaloids: ≥0.1%. Example

[0020] like Figure 1-5As shown, based on Example 2, the present invention provides a compound bactericide mixing device: preferably, it includes a traditional Chinese medicine extraction mechanism 1 and a mixing tank 2. The traditional Chinese medicine extraction mechanism 1 is located on the left side of the mixing tank 2. The traditional Chinese medicine extraction mechanism 1 includes a base plate 11. A lifting column 12 and an inverted J-shaped bracket 18 are fixedly installed on the top left side of the base plate 11. The vertical part of the inverted J-shaped bracket 18 is located on the left side of the lifting column 12. A sliding groove 13 is opened on the right side of the lifting column 12. An upgraded drive motor 14 is fixedly installed on the top of the lifting column 12. The output shaft of the upgraded drive motor 14 passes through the inner cavity of the sliding groove 13 and is fixedly installed with a threaded rod 1. 5. A lifting plate 16 is threaded onto the outer wall of the threaded rod 15. A Chinese medicine extraction tank 17 is fixedly installed on the right end of the lifting plate 16. A Chinese medicine circular filter screen 181 is fixedly installed at the bottom right vertical position of the inverted J-shaped bracket 18. The outer wall of the Chinese medicine circular filter screen 181 overlaps with the inner wall of the Chinese medicine extraction tank 17. An L-shaped drain pipe 171 is fixedly connected to the bottom of the Chinese medicine extraction tank 17. An electric control valve 172 is fixedly installed on the outer wall of the L-shaped drain pipe 171. A drain pipe groove 111 is opened on the top of the base plate 11. The L-shaped drain pipe 171 and the electric control valve 172 are both located inside the drain pipe groove 111 after the Chinese medicine extraction tank 17 is lowered.

[0021] In this embodiment, during preparation, all six kinds of traditional Chinese medicine are directly placed into the inner cavity of the traditional Chinese medicine extraction tank 17, and water is poured directly into the inner cavity from the top of the traditional Chinese medicine extraction tank 17 to soak and extract the traditional Chinese medicine. After soaking for a period of time, the traditional Chinese medicine and water form a traditional Chinese medicine extract. At this time, the upgraded drive motor 14 at the top of the lifting column 12 can be started, thereby driving the threaded rod 15 to rotate in the slide groove 13. With the threaded connection between the lifting plate 16 and the outer wall of the threaded rod 15, the entire traditional Chinese medicine extraction tank 17 can be lowered until the L-shaped drain pipe 171 is inserted into the drain pipe groove 111 and stops. At this time, the traditional Chinese medicine circular filter screen 181 at the bottom right side of the inverted J-shaped bracket 18 rises, and the traditional Chinese medicine extract is filtered and exists on the top of the traditional Chinese medicine circular filter screen 181. The traditional Chinese medicine extract can be discharged by opening the electric control valve 172 on the outer wall of the L-shaped drain pipe 171, thereby facilitating the removal of the traditional Chinese medicine extract. Example

[0022] like Figure 1-5As shown, based on Embodiment 3, the present invention provides a technical solution: Preferably, a liquid pump 21 is fixedly installed on the top left side of the mixing tank 2, a connecting hose 211 is fixedly connected to the input end of the liquid pump 21, the left input end of the connecting hose 211 is fixedly connected to the right end of the L-shaped drain pipe 171, the output end of the liquid pump 21 extends through the inner cavity of the mixing tank 2, a traditional Chinese medicine extract addition port 22 is fixedly connected to the top rear side of the mixing tank 2, a silver ion addition pipe 23 is fixedly connected to the top right side of the mixing tank 2, a stirring motor 24 is fixedly installed at the bottom center of the mixing tank 2, the output shaft of the stirring motor 24 extends through the inner cavity of the mixing tank 2 and a rotating rod 241 is fixedly installed, blades 242 are evenly fixedly installed on the outer wall of the rotating rod 241, a plurality of stirring rods 243 are evenly fixedly installed on the lower part of the outer wall of the rotating rod 241, and a liquid outlet pipe 25 is fixedly connected to the lower right side of the mixing tank 2.

[0023] In this embodiment, by activating the pump 21 at the top of the mixing tank 2, the traditional Chinese medicine extract in the extraction tank 17 can be drawn into the inner cavity of the mixing tank 2 through the connection of the flexible connecting hose 211 and the L-shaped drain pipe 171. Then, the traditional Chinese medicine extract can be added into the mixing tank 2 through the traditional Chinese medicine extract addition port 22, and silver ions or water can be added into the inner cavity of the mixing tank 2 through the silver ion addition pipe 23. Finally, the stirring motor 24 drives the rotating rod 241 in the inner cavity of the mixing tank 2 to rotate, thereby using the stirring rod 243 to stir and mix the various materials in the mixing tank 2. At the same time, the blade 242 on the outer wall of the rotating rod 241 can break up the solid traditional Chinese medicine extract that falls into the inner cavity of the mixing tank 2 through the traditional Chinese medicine extract addition port 22, thereby improving the mixing efficiency.

[0024] The working principle of the compound bactericide mixing and stirring device will be explained in detail below.

[0025] like Figure 1-5As shown, during preparation, six kinds of traditional Chinese medicine are directly placed into the inner cavity of the herbal extraction tank 17, and water is poured directly into the inner cavity from the top of the herbal extraction tank 17 to soak and extract the herbs. After soaking for a period of time, the herbs and water form a herbal extract. At this time, the upgraded drive motor 14 at the top of the lifting column 12 can be activated, thereby driving the threaded rod 15 to rotate in the slide groove 13. With the threaded connection between the lifting plate 16 and the outer wall of the threaded rod 15, the entire herbal extraction tank 17 can be lowered until the L-shaped drain pipe 171 is inserted into the drain pipe groove 111 and stops. At this time, the herbal circular filter screen 181 at the bottom right side of the inverted J-shaped bracket 18 rises, and the herbal extract is filtered and exists on the top of the herbal circular filter screen 181. The herbal extract can be released by opening the electric control valve 172 on the outer wall of the L-shaped drain pipe 171. The process involves draining the herbal extract from the mixing tank 2 to facilitate the removal of the herbal extract. Simultaneously, by activating the pump 21 at the top of the mixing tank 2 and connecting the flexible hose 211 to the L-shaped drain pipe 171, the herbal extract from the extraction tank 17 can be drawn into the inner cavity of the mixing tank 2. Then, the herbal extract can be added into the mixing tank 2 through the herbal extract inlet 22, and silver ions or water can be added into the inner cavity of the mixing tank 2 through the silver ion inlet 23. Finally, the stirring motor 24 drives the rotating rod 241 inside the mixing tank 2 to rotate, thereby using the stirring rod 243 to stir and mix the various materials in the mixing tank 2. At the same time, the blade 242 on the outer wall of the rotating rod 241 can break up the solid herbal extract that falls into the inner cavity of the mixing tank 2 through the herbal extract inlet 22, thereby improving the mixing efficiency.

[0026] The present invention has been described in detail above. However, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, any modifications or improvements that do not depart from the spirit of the present invention are within the scope of protection of the present invention.

Claims

1. A composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts, characterized in that: The ingredients include: Sophora flavescens: 30g, Phellodendron chinense: 10g, Smilax glabra: 30g, Cnidium monnieri: 15g, Artemisia capillaris: 10g, Lonicera japonica: 10g, silver ions with a silver content of 5000ppm: 20g, and prepared into 1000ml. Silver ions are positively charged cations formed by metallic silver losing one or more electrons, including Ag1+, Ag2+, and Ag3+, which exist in the form of an aqueous solution.

2. The composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts according to claim 1 is hereby further described as follows: A method for preparing the composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts is characterized by: Includes the following steps: S1: Take six kinds of Chinese herbs, namely Sophora flavescens, Phellodendron chinense, Smilax glabra, Cnidium monnieri, Artemisia capillaris, and Lonicera japonica, and extract them with water for later use; S2: Add nano-sized silver ions to the traditional Chinese medicine extract and stir to mix; S3: Continue to add the Chinese herbal extract to the mixture in S2, mix and stir, and test the content indicators.

3. The method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts according to claim 2, characterized in that: After taking the six Chinese herbs in S1, water needs to be added twice, with the amount of water added being 10 times and 8 times respectively, and the extraction time being 2 hours and 1 hour respectively. The filtrates are combined and concentrated to a relative density between 1.18 and 1.22, and then filtered for later use.

4. The method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts according to claim 2, characterized in that: In step S2, nano-sized silver ions need to be added to the herbal extract in step S1 at a dosage of 2%, and stirred continuously for 10 minutes, while replenishing with purified water in a timely manner.

5. The method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extracts according to claim 2, characterized in that: In step S3, 10 kg of baicalin and 10 kg of chlorogenic acid, the traditional Chinese medicine extracts from step S1, are added successively and stirred for 15 minutes. Samples are taken to check the solubility. After complete dissolution, the content indicators are tested, with the test indicators being silver ions: ≥100 ppm and alkaloids: ≥0.1%.

6. According to claim 2, a method for preparing a composite bactericide of nano-sized silver ions and traditional Chinese medicine extract is now proposed, comprising a traditional Chinese medicine extraction mechanism (1) and a stirring tank (2), characterized in that: The herbal medicine extraction mechanism (1) is located on the left side of the mixing tank (2). The herbal medicine extraction mechanism (1) includes a base plate (11). A lifting column (12) and an inverted J-shaped bracket (18) are fixedly installed on the top left side of the base plate (11). The vertical part of the inverted J-shaped bracket (18) is located on the left side of the lifting column (12). A sliding groove (13) is opened on the right side of the lifting column (12). An upgraded drive motor (14) is fixedly installed on the top of the lifting column (12). The output shaft of the upgraded drive motor (14) passes through the inner cavity of the sliding groove (13) and is fixedly installed with a threaded rod (15). A lifting plate (16) is threaded on the outer wall of the threaded rod (15). A herbal medicine extraction tank (17) is fixedly installed on the right end of the lifting plate (16).

7. The compound bactericide mixing and stirring device according to claim 6, characterized in that: A circular filter screen (181) for Chinese medicine is fixedly installed at the bottom of the right vertical position of the inverted J-shaped bracket (18). The outer wall of the circular filter screen (181) overlaps with the inner wall of the Chinese medicine extraction tank (17). An L-shaped drain pipe (171) is fixedly connected to the bottom of the Chinese medicine extraction tank (17). An electric control valve (172) is fixedly installed on the outer wall of the L-shaped drain pipe (171). A drain pipe groove (111) is opened on the top of the base plate (11). The L-shaped drain pipe (171) and the electric control valve (172) are both located inside the drain pipe groove (111) after the Chinese medicine extraction tank (17) is lowered.

8. The compound bactericide mixing and stirring device according to claim 6, characterized in that: A liquid pump (21) is fixedly installed on the top left side of the mixing tank (2). A connecting hose (211) is fixedly connected to the input end of the liquid pump (21). The left input end of the connecting hose (211) is fixedly connected to the right end of the L-shaped drain pipe (171). The output end of the liquid pump (21) extends through the inner cavity of the mixing tank (2). A Chinese herbal extract addition port (22) is fixedly connected to the rear top side of the mixing tank (2). A silver ion addition tube (23) is fixedly connected to the right top side of the mixing tank (2). A stirring motor (24) is fixedly installed at the center of the bottom of the mixing tank (2). The output shaft of the stirring motor (24) extends through the inner cavity of the mixing tank (2) and a rotating rod (241) is fixedly installed. Blades (242) are evenly fixedly installed on the upper outer wall of the rotating rod (241). Several stirring rods (243) are evenly fixedly installed on the lower outer wall of the rotating rod (241). An outlet pipe (25) is fixedly connected to the lower right side of the mixing tank (2).