Composition and application thereof

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to a composition and application thereof. The invention relates to a composition, in particular to a composition with repairing and anti-wrinkle effects and application thereof. The invention provides a composition. The composition is prepared from garcinia indica seed grease, phytosterol macadamia nut oleate, a castor oil / IPDI (isophorone diisocyanate) copolymer and a saussurea involucrata extract. When the composition is used, through the synergistic effect of all the components, hydrogen bonds are connected in multiple directions, crystals are prevented from simply growing into large sheet shapes or needle shapes, and tiny, fiber-shaped or needle-shaped microcrystals tend to be formed. The microcrystals are mutually crosslinked and overlapped to construct a continuous layered network structure penetrating through the whole matrix, and excellent repairing and anti-wrinkle effects can be formed. And the components are natural, safe and mild, do not irritate the lip skin, and are suitable for long-term use.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of skin care products, in particular, relates to a composition and application thereof; more particularly, relates to a composition with repairing and anti-wrinkle effects and application thereof. BACKGROUND

[0002] Human skin is easily affected by the external environment, leading to dryness, peeling, cracking, etc. In particular, the skin of the lips is thinner than other parts of the face, with abundant blood vessels, no sweat glands and sebaceous glands, and cannot self-moisturize. In addition, some ingredients in lip care products or lipsticks can cause allergic reactions, causing redness, itching or discomfort. In addition to external environmental pollution, ultraviolet radiation, dry air conditioning environment, and the influence of the accelerated pace of life, more and more people will have cracked lips, wrinkles, inflammation, and whitening.

[0003] Existing lip care products are mainly moisturizing, a few have anti-wrinkle effects, and are not good at repairing the lips, and may contain irritating ingredients, which are not suitable for long-term use.

[0004] Therefore, there is a need in the art for a product that has nourishing and repairing effects, can improve the health of the skin in daily lip care, is safe and mild, does not irritate the skin of the lips, and is suitable for long-term use. SUMMARY

[0005] In view of the deficiencies of the prior art, the purpose of the present application is to provide a composition with nourishing and repairing effects, which can improve the health of the skin in daily lip care, and is safe and mild, does not irritate the skin of the lips, and is suitable for long-term use.

[0006] Therefore, the present application provides a composition, comprising: Indian tallow seed oil, phytosteryl australiannut oilate, castor oil / IPDI copolymer, and saussurea involucrata extract.

[0007] Applicants have creatively found that the use of the composition of the present application, through the synergistic effect of each component, the connection of hydrogen bonds in multiple directions hinders the simple growth of crystals into large flaky or needle-shaped, but tends to form fine, fibrous or needle-shaped microcrystals. These microcrystals are cross-linked and overlapped to form a continuous layered network structure throughout the entire matrix, which can form excellent repair and anti-wrinkle effects. And its ingredients are derived from nature, safe and mild, do not irritate the skin of the lips, and are suitable for long-term use.

[0008] In some specific embodiments, the Indian walnut seed fat is comprised in an amount of 5-20% by weight of the total composition, preferably 10-15%. For example, it can be comprised in an amount of 10%, 11%, 12%, 13%, 14%, 15% by weight of the total composition. For example, 5-20 g of Indian walnut seed fat, preferably 10-15 g of Indian walnut seed fat, can be comprised per 100 g of the composition of the present application.

[0009] In some specific embodiments, the phytosteryl macadamia nut oilate is comprised in an amount of 20-30% by weight of the total composition, preferably 25-30%. For example, it can be comprised in an amount of 25%, 26%, 27%, 28%, 29%, 30% by weight of the total composition. For example, 20-30 g of phytosteryl macadamia nut oilate, preferably 25-30 g of phytosteryl macadamia nut oilate, can be comprised per 100 g of the composition of the present application.

[0010] In some specific embodiments, the castor oil / IPDI copolymer is comprised in an amount of 5-15% by weight of the total composition, preferably 5-10%. For example, it can be comprised in an amount of 5%, 6%, 7%, 8%, 9%, 10% by weight of the total composition. For example, 5-15 g of castor oil / IPDI copolymer, preferably 5-10 g of castor oil / IPDI copolymer, can be comprised per 100 g of the composition of the present application.

[0011] In some specific embodiments, the saussurea costus extract is comprised in an amount of 45-60% by weight of the total composition, preferably 45-50%. For example, it can be comprised in an amount of 45%, 46%, 47%, 48%, 49%, 50% by weight of the total composition. For example, 45-60 g of saussurea costus extract, preferably 45-50 g of saussurea costus extract, can be comprised per 100 g of the composition of the present application.

[0012] In some specific embodiments, the composition comprises 20 wt% of Indian walnut seed fat, 25 wt% phytosteryl macadamia nut oilate, 10 wt% castor oil / IPDI copolymer, and 45 wt% saussurea costus extract.

[0013] In some specific embodiments, the composition comprises 15 wt% of Indian walnut seed fat, 30 wt% phytosteryl macadamia nut oilate, 5 wt% castor oil / IPDI copolymer, and 50 wt% saussurea costus extract.

[0014] In some specific embodiments, the composition comprises 5 wt% of Indian walnut seed fat, 20 wt% phytosteryl macadamia nut oilate, 15 wt% castor oil / IPDI copolymer, and 60 wt% saussurea costus extract.

[0015] In some embodiments, the composition comprises 5-20 wt% of Indian gurjan balsam seed oil, 20-30 wt% of phytosteryl macadamia nut oilate, 5-15 wt% of castor oil / IPD, and 45-60 wt% of saussurea involucrata extract.

[0016] The inherent synergistic effect of the composition of the present application can be better performed by using the components in the above-mentioned proportions, thereby further increasing the repair and anti-wrinkle effects of the composition.

[0017] Further, the composition can further comprise other components, for example, a solvent for dissolving the other components into a liquid state, and a carrier for mixing the other components and forming a certain state, for example, a solid state, a fluid state, etc. One or more than two of them can be combined as long as the effects of the present application are exerted. For example, the composition of the present application can comprise caprylic / capric triglyceride for dissolving the saussurea involucrata extract.

[0018] In some embodiments, the composition further comprises a solvent, and the solvent accounts for 10-50% of the total mass of the composition. For example, the solvent can account for 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% of the total mass of the composition.

[0019] In some embodiments, the composition further comprises a carrier, and the carrier accounts for 10-50% of the total mass of the composition. For example, the carrier can account for 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% of the total mass of the composition.

[0020] In a second aspect, the present application provides a use of the above-mentioned composition for a cosmetic and / or skin care product for repair and / or anti-wrinkle.

[0021] In a specific embodiment, a use of the above-mentioned composition for a cosmetic and / or skin care product for repair is provided.

[0022] In a specific embodiment, a use of the above-mentioned composition for a cosmetic and / or skin care product for anti-wrinkle is provided.

[0023] In a third aspect, the present application provides a use of the above-mentioned composition for preparing a cosmetic and / or skin care product for repair and / or anti-wrinkle.

[0024] In a specific embodiment, a use of the above-mentioned composition for preparing a cosmetic and / or skin care product for repair is provided.

[0025] In a specific embodiment, a use of the above-mentioned composition for preparing a cosmetic and / or skin care product for anti-wrinkle is provided.

[0026] Further, the use of the above composition for skin repair and / or anti-wrinkle, and / or lip repair and / or anti-wrinkle efficacy is provided.

[0027] Further, the cosmetic and / or skin care product can be used on the face or on the lips.

[0028] Preferably, the cosmetic and / or skin care product can be a lip cosmetic or a lip skin care product.

[0029] In a fourth aspect, the present application provides a cosmetic and / or skin care product comprising the above composition.

[0030] Further, the mass fraction of the composition in the cosmetic and / or skin care product is 0.01%-5%, which can be 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, preferably, the mass fraction of the composition in the cosmetic and / or skin care product is 2%.

[0031] For example, 0.01g-5g of the composition of the present application can be included in 100g of the cosmetic and / or skin care product, such as 0.01g, 0.05g, 0.1g, 0.5g, 1g, 2g, 3g, 4g, 5g of the composition of the present application, preferably, 2g of the composition of the present application can be included in 100g of the cosmetic and / or skin care product.

[0032] In some specific embodiments, 0.1g-0.4g of Indian gurjan balsam seed fat, 0.4g-0.6g of phytosteryl macadamia arachidinate, 0.1g-0.3g of castor oil / IPDI copolymer, and 0.9g-1.2g of saussurea involucrata extract can be included in 100g of the cosmetic and / or skin care product.

[0033] Further, the cosmetic and / or skin care product can be used on the face or on the lips.

[0034] Preferably, the cosmetic and / or skin care product can be a lip cosmetic or a lip skin care product.

[0035] The lip cosmetic and / or skin care product can be a lipstick, lip gloss, lip balm, lip color, lip stick, lip cream, etc.

[0036] As the dosage form that can be used as a cosmetic and / or skin care product, a stick, a dish, an ointment, etc. can be used.

[0037] In the present application, in the cosmetic and / or skin care product, in addition to the above-mentioned components, any component generally used in cosmetics and / or skin care products, pharmaceutical products can be combined. As the arbitrary component, the following components can be cited, and one or two or more kinds thereof can be combined as long as the effect of the present application is exerted.

[0038] In some specific embodiments, the cosmetic and / or skin care product of the present application further comprises one or more of an emollient, a filler, a colorant, a synthetic wax, an oil, a humectant, a preservative, a binder, a thickening agent, or an emulsifier.

[0039] The cosmetic and / or skin care product of the present application can contain water in any amount. As the water, water used in cosmetics, quasi-drugs, and the like can be used, for example, ion-exchanged water, distilled water, ultrapure water, tap water, and the like can be used.

[0040] In some specific embodiments, the filler of the present application can be one or more of silica, polymethylsilsesquioxane, mica, white mica, phlogopite, synthetic mica, red mica, or black mica.

[0041] Further, the cosmetic and / or skin care product for the lips can be a colorless lip cosmetic and / or skin care product or a colored lip cosmetic and / or skin care product.

[0042] Further, the lip cosmetic and / or skin care product comprises a colorant.

[0043] In some specific embodiments, the colored lip product comprises a colorant, for example, CI 77491, CI 15850, CI 77499, CI 77891, CI 77492, and the like, and can be titanium dioxide, iron red, red 7, iron yellow, iron black, and the like, and preferably, can be one or more of the aforementioned colorants.

[0044] In some specific embodiments, the synthetic wax of the present application can be exemplified by microcrystalline wax, beeswax, candelilla wax, ozokerite, cotton wax, carnauba wax, bayberry wax, insect wax, whale wax, montan wax, rice chaff wax, lanolin, kapok wax, acetylated lanolin, lanolin oil, sugar cane wax, isopropyl lanolate, hexyl laurate, hydrogenated lanolin, jojoba wax, hard lanolin, shellac wax, and the like.

[0045] In some specific embodiments, the humectant of the present application can be exemplified by polyethylene glycol, propylene glycol, glycerin, 1,3-butanediol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucin sulfate, cholesteryl-12-hydroxystearate, sodium lactate, bile acid salt, pyrrolidone carboxylate, short-chain soluble collagen, diglycerol PO adduct, yarrow extract, sage extract, and the like.

[0046] In some embodiments, the preservatives of the present application can include methylparaben, ethylparaben, butylparaben, benzoic acid, salicylic acid, sorbic acid, p-chloro-m-cresol, hexachlorophene, benzalkonium chloride, chlorhexidine, triclocarban, photosensitizers, phenoxyethanol, and the like.

[0047] In some embodiments, the thickening agents of the present application can include acacia, carrageenan, carrageenan gum, gum tragacanth, locust bean gum, casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, propolis, silicic anhydride, and the like.

[0048] In some embodiments, the emulsifiers of the present application can include non-ionic surfactants, amphiphilic polymers, such as (acrylates / steareth-20 methacrylate copolymer), hydrophobically modified alkyl cellulose, hydrogenated lecithin, sorbitan laurate, sorbitan palmitate, sorbitan oleate, sorbitan stearate, sorbitan isostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan tristearate, sorbitan sesquiisostearate.

[0049] In some embodiments, the lip care product and / or skin care product of the present application can include the composition of the present application, hydrogenated polydecene, tridecane alcohol trimellitate, bis-diglyceryl polyacyladipate-2, dimethysilylated silica, microcrystalline wax, euphorbia cerifera wax, phenoxyethanol.

[0050] In some embodiments, the lip care product and / or skin care product of the present application can include: 2 wt% of the composition of the present application, 32 wt% hydrogenated polydecene, 17 wt% tridecane alcohol trimellitate, 15 wt% bis-diglyceryl polyacyladipate-2, 3 wt% dimethysilylated silica, 28 wt% microcrystalline wax, 2 wt% euphorbia cerifera wax, 1 wt% phenoxyethanol.

[0051] In a fourth aspect, the present application provides a synthetic carrier, wherein at least one layer of the composition of the present application or the lip care product and / or skin care product of the present application is present on part or all of the surface of the carrier.

[0052] In a fifth aspect, the present application provides a method for preparing a cosmetic and / or skin care product, comprising the following steps: mixing and weighing the components of the composition of the present application; mixing and stirring the weighed raw materials at 85-90°C until completely melted; further adding one or more of synthetic wax, oil, emollient, filler, colorant, preservative, binder, thickening agent, stabilizer, or emulsifier, heating and stirring uniformly, and grinding; further stirring uniformly after heating the ground product, preparing a flowable body, and finally preparing the cosmetic and / or skin care product.

[0053] In some specific embodiments, the following steps are included: mixing and weighing the components of the composition of the present application; mixing and stirring the weighed raw materials at 85-90°C until completely melted; heating the synthetic wax and / or oil at 90-100°C until completely melted; mixing and stirring the above ingredients uniformly, further adding one or more of synthetic wax, oil, emollient, filler, colorant, preservative, binder, thickening agent, stabilizer, or emulsifier, heating and stirring uniformly, and grinding; and further stirring uniformly after heating the ground product, preparing a flowable body, and finally preparing the cosmetic and / or skin care product. BRIEF DESCRIPTION OF DRAWINGS

[0054] Fig. 1-11 Microstructure of the composition of Example 1-11 of the present application. DETAILED DESCRIPTION

[0055] The present application will be specifically described below in connection with specific embodiments and examples, and the advantages and various effects of the present application will be more clearly presented thereby. Those skilled in the art will understand that these specific embodiments and examples are for illustrating the present application, not limiting the present application.

[0056] The "range" disclosed in the present application is defined in the form of lower limit and upper limit, and a given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundary of a specific range. The range defined in this way can be inclusive or exclusive of the end values, and can be arbitrarily combined, i.e., any lower limit can be combined with any upper limit to form a range.

[0057] In the present application, unless otherwise specified, the numerical range "a-b" represents a shorthand notation for any real combination of the numbers between a and b, wherein a and b are both real numbers. For example, the numerical range "0-5" represents that all real numbers between "0-5" have been listed herein, and "0-5" is just a shorthand notation for these numerical combinations. In addition, when it is stated that a parameter is an integer ≥ 2, it is equivalent to disclose that the parameter is, for example, integer 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, and the like.

[0058] Unless otherwise specified, all embodiments and optional embodiments of the present application can be combined with each other to form new technical solutions. Unless otherwise specified, all technical features and optional technical features of the present application can be combined with each other to form new technical solutions.

[0059] Unless otherwise specified, all steps of the present application can be performed in sequence or randomly, and preferably in sequence. For example, the method comprises steps (a) and (b), which means that the method can comprise steps (a) and (b) performed in sequence, or steps (b) and (a) performed in sequence. For example, the method also comprises step (c), which means that step (c) can be added to the method in any order, for example, the method can comprise steps (a), (b) and (c), or steps (a), (c) and (b), or steps (c), (a) and (b), and the like.

[0060] Hereinafter, the embodiments of the present application are described. The embodiments described below are exemplary and are only used to explain the present application, and cannot be understood as a limitation of the present application. If the specific technology or condition is not specified in the embodiments, it is performed according to the technology or condition described in the literature in the art or according to the product instruction. If the reagent or instrument used is not specified by the manufacturer, it is a conventional product that can be obtained by purchase.

[0061] Definitions "Indian tallow" refers to a lipid material derived from the seed of Garcinia indica.

[0062] "Phytosteryl macadamia nut oilate" refers to a compound esterified by phytosterol and macadamia nut oil acid (the main component is oleic acid).

[0063] "Caster oil / IPDI copolymer" refers to a high molecular material synthesized by natural oil (castor oil) and aliphatic diisocyanate (IPDI), which has good stability.

[0064] "Snow Lotus (SAUSSUREA INVOLUCRATA) extract" refers to the components obtained by separating and concentrating the callus tissue or artificially cultivated materials of the rare alpine plant Snow Lotus through modern extraction processes (such as solvent extraction, supercritical extraction, etc.).

[0065] Formulation of the composition of the present invention The formulations of the compositions of the present invention are shown in Table 1. Specific differences are shown in Table 2.

[0066] Table 1

[0067] Table 2

[0068] Testing of the repair efficacy of the composition Detection principle The regenerative efficacy of the formulation was tested using a zebrafish regeneration efficacy assay. The principle involves surgically severing the caudal fin perpendicular to the trunk and evaluating the regenerative efficacy of the sample by quantitatively measuring the area of ​​the regenerated caudal fin. Zebrafish caudal fin regeneration is divided into three processes: wound healing, bud formation, and regeneration outcome, with bud formation being the most crucial. Cells involved in fin regeneration originate from multiple sources, including epidermal cells, fibroblasts, and osteoblasts, all of which promote caudal fin regeneration and exhibit high lineage restriction. The regeneration mechanism of zebrafish caudal fins is similar to that of human skin, bone, and blood vessels. Due to its simple structure, ease of surgical manipulation, lack of postoperative impact on survival, and ease of observation, the zebrafish caudal fin has become an important model for studying tissue regeneration processes.

[0069] Detection steps and result analysis A zebrafish caudal fin injury model was established by surgically removing the caudal fin of zebrafish. The model zebrafish were randomly assigned to 6-well plates, with 15 fish per well. Water-soluble samples were administered, and a normal control group and a model control group were also set up, with a volume of 3 mL per well. The plates were incubated at 28℃ in the dark for 48 h. Ten zebrafish from each experimental group were randomly selected and photographed under a dissecting microscope. Advanced image processing software was used to analyze and collect data, analyzing the caudal fin area (A). The repair efficacy of the samples was calculated according to a formula to determine whether they possessed repair efficacy. Statistical analysis showed p < 0.05 as a significant difference. The results are shown in Table 3.

[0070] Table 3

[0071] Testing of the composition's repair and anti-wrinkle effects Detection principle Detection principle The anti-wrinkle effect of the group formula is tested by using the zebrafish anti-wrinkle effect test method. The growth, repair, nutrition, elasticity and tension of the skin are related to collagen, and its loss will reduce the smoothness of the skin and produce wrinkles. In quadruped animals, type I collagen is a trimer, mainly composed of two a1 chains and one a2 chain, encoded by col1a1a and col1a2 genes, and performs collagen-related biological functions in connective tissue and bone. There are three type I collagen genes in zebrafish, which encode col1a1a, col1a1b and col1a2, which encode a1 (I), a2 (I) and a3 (I) chains, respectively. Therefore, by detecting the relative expression of col1a1a or (and) col1a1b or (and) col1a2 genes, it can be shown whether the sample has anti-wrinkle effect.

[0072] Detection step and result analysis Randomly select zebrafish in a 6-well plate, 30 per well. Water-soluble samples are given, and normal control groups are set up, with a volume of 3 mL per well. Three biological repeats. Incubate at 28°C in the dark for 24 h. Extract total RNA from zebrafish in each experimental group, synthesize cDNA, and use q-PCR to detect the gene expression of β-actin and the target gene. Use β-actin as the internal reference for gene expression to calculate the RNA relative expression of the target gene, and the results are shown in Table 4.

[0073] Table 4

[0074] Microscopic observation of the microstructure of the composition The Leica Model DM2500 LED microscope is used to observe the crystallization performance of the group formula, which can provide direct visual evidence to help determine the crystallization behavior of the sample under various conditions. The following are the detailed steps for observing the crystallization performance using the Leica DM2500 LED microscope. The sample is spread on a glass slide to flatten it for microscopic observation. Cover the sample with a cover glass to ensure uniform distribution and stable fixation. Turn on the Model DM2500 LED microscope and make sure that the light and camera equipment are working properly. Start with low magnification and gradually increase the magnification to observe the overall crystalline morphology of the sample and record the crystalline characteristics of different samples. Use high magnification to observe the local crystalline structure in detail to ensure that the details of the crystalline structure, such as size, shape and distribution, are captured. Use the built-in camera of the microscope to take clear images of the sample.

[0075] The sample images are shown in Fig. 1-11 As can be seen from the figure, Examples 1-3 form a layered crystalline network structure, among which Example 2 clearly shows a uniform and tight layered crystalline network structure. Examples 4-11 have uneven or loose crystalline morphology.

[0076] The composition of the present application is used to prepare a lip product A specific lip product is prepared using the formulation of Example 2, the specific formulation is shown in Table 5 below, and the preparation method is shown as follows: The composition of the present application is mixed and weighed, the weighed raw materials are mixed and stirred at 85-90°C until completely melted, further added with waxy, oil heated to 90-100°C completely melted, added with dimethyl silyl silica stirred evenly, three roll mill grinding three times, added with preservative, heated and stirred evenly at 85-95°C, prepared into a flow body, filled, cooled, demolded to obtain a lip product.

[0077] Table 5

[0078] It should be noted that the present application is not limited to the above-mentioned embodiments. The above-mentioned embodiments are only examples, and embodiments having the same technical idea and playing the same role and effect within the scope of the technical solution of the present application are all included in the technical scope of the present application. In addition, within the scope of the main idea of the present application, various modifications that can be thought of by those skilled in the art are applied to the embodiments, and other ways constructed by combining part of the constituent elements in the embodiments are also included in the scope of the present application.

Claims

1. A composition comprising: Indian Garcinia Cambogia seed oil, phytosterol macadamia oleate, castor oil / IPDI copolymer, and snow lotus extract.

2. The composition according to claim 1, characterized in that, The composition satisfies at least one of the following conditions: The Indian Garcinia Cambogia seed oil accounts for 5%-20% of the composition by mass; The phytosterol macadamia oleate accounts for 20%-30% of the composition by mass; The castor oil / IPDI copolymer accounts for 5%-15% of the mass of the composition; or The snow lotus extract accounts for 45%-60% of the composition by mass.

3. The composition according to claim 2, characterized in that, The composition comprises: 5%-20wt% Garcinia Cambogia seed oil, 20%-30wt% phytosterol macadamia oleate, 5%-15wt% castor oil / IPD, 45%-60wt% snow lotus extract.

4. Use of the composition according to any one of claims 1 to 3 in cosmetics and / or skin care products for repair and / or anti-wrinkle purposes.

5. The use according to claim 3, characterized in that, The cosmetics and / or skincare products mentioned are lip cosmetics and / or skincare products.

6. Use of the composition according to any one of claims 1 to 3 in the preparation of cosmetics and / or skin care products for repair and / or anti-wrinkle purposes.

7. A cosmetic and / or skin care product comprising the composition of any one of claims 1 to 3.

8. The cosmetics and / or skincare products according to claim 7, characterized in that, The composition comprises 0.01-5% by mass in cosmetics and / or skin care products.

9. The cosmetics and / or skincare products according to claim 8, characterized in that, The cosmetic further includes one or more of the following: emollients, fillers, colorants, functional agents, thickeners, preservatives, humectants, or emulsifiers.

10. The cosmetic according to any one of claims 7 to 9, characterized in that, The cosmetics and / or skincare products also include: hydrogenated polydecene, tridecyltriphenyltrate, bis-diglyceride polyacryladiate-2, dimethylsilyl silica, microcrystalline wax, candelilla wax, and phenoxyethanol.

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