Mobile phase preparation system

Abstract

The invention discloses a mobile phase preparation system, and relates to the technical field of medicine preparation, the mobile phase preparation system comprises a material supply module, a powder adding module, a liquid adding module, a suction filtration module and an ultrasonic degassing module which are arranged along the execution direction of a flow; the liquid adding module is used for mixing a liquid reagent and powder and adjusting the PH value so as to obtain a prepared liquid in the liquid preparation container; the suction filtration module is used for sucking and filtering configuration liquid in the liquid preparation container into a target container at the discharging station, the target container is located below the suction filtration module, and the suction filtration module comprises a first channel used for being communicated with the liquid preparation container and a second channel used for being communicated with a vacuum source and generating negative pressure in the target container; the liquid in the liquid preparation container enters the target container after being filtered by the suction filtration module through the first channel under the negative pressure effect of the target container; and the ultrasonic degassing module is used for degassing the liquid in the target container. According to the mobile phase preparation system provided by the invention, the mobile phase preparation efficiency and safety can be improved, and the product quality is ensured.

Description

Technical Field

[0001] This application relates to the field of pharmaceutical preparation technology, and more specifically, to a mobile phase preparation system. Background Technology

[0002] In related fields, the process flow for mobile phase preparation generally includes quantitative addition of powder and liquid, pH adjustment, filtration, and degassing. Some processes also require labeling of the mobile phase bottles. However, traditional mobile phase preparation is usually done manually, resulting in low mobile phase preparation efficiency, significant safety risks, and an inability to guarantee product quality stability.

[0003] Therefore, how to improve the efficiency and safety of mobile phase preparation and ensure product quality has become a technical problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0004] In view of this, the purpose of this application is to provide a mobile phase preparation system to improve the efficiency and safety of mobile phase preparation and ensure product quality.

[0005] To achieve the above objectives, this application provides the following technical solution:

[0006] A mobile phase preparation system includes a feeding module for providing liquid reagents, a powder adding module for providing powder, a liquid adding module, a filtration module, and an ultrasonic degassing module, all arranged along the execution direction of the process, wherein:

[0007] The liquid addition module is used to mix the liquid reagent and the powder and adjust the pH value to obtain the prepared solution in the liquid preparation container;

[0008] The filtration module is used to filter the prepared liquid in the liquid preparation container into the target container at the unloading station. The target container is located below the filtration module. The filtration module includes a first channel for communicating with the liquid preparation container and a second channel for communicating with a vacuum source and generating negative pressure in the target container, so that the liquid in the liquid preparation container enters the target container after being filtered by the filtration module through the first channel under the negative pressure of the target container.

[0009] The ultrasonic degassing module is used to degas the liquid in the target container.

[0010] Optionally, in the above-described mobile phase preparation system, a filter membrane is disposed below the first channel of the filtration module. The filtration module further includes a third channel and a flow-driving device. One end of the flow-driving device is used to communicate with the liquid dispensing container of the liquid addition module, and the other end of the flow-driving device is used to communicate with the third channel. The flow-driving device is used to drive the liquid in the liquid dispensing container to enter the target container through the third channel after being filtered by the filtration module when the filter membrane is a liquid-permeable but air-permeable membrane.

[0011] Optionally, in the above-described mobile phase preparation system, the filtration module includes a filtration body, the lower end of which is provided with a filtration interface for docking and communicating with a target container. The first channel, the second channel, and the third channel are all located on the upper surface of the filtration body, and the first channel and the third channel extend into the interior of the filtration body and communicate with the filtration interface.

[0012] Optionally, in the above-described mobile phase preparation system, the filtration body includes a base, a first connecting part, and a second connecting part. The first channel and the third channel are both disposed on the first connecting part, the second channel is disposed on the base, the second connecting part is sleeved on the outside of the first connecting part, and the second connecting part is connected to the base, so that the second connecting part presses the first connecting part onto the base.

[0013] Optionally, in the above-described mobile phase preparation system, the filtration body has a filtration chamber for containing the liquid to be filtered, the filtration membrane is located in the filtration chamber, the first connecting part has a first chamber, the base part has a second chamber, the first connecting part is embedded in the second chamber, and the filtration chamber includes at least the first chamber and the second chamber.

[0014] Optionally, in the above-described mobile phase preparation system, the outer wall of the first connecting part extends in a direction away from the central axis of the first connecting part to form a protrusion, the protrusion being used to press the filter membrane in the filter chamber, and the side wall of the second chamber is provided with a stepped part, the protrusion being provided with a stepped surface that cooperates with the stepped part.

[0015] Optionally, in the above-described mobile phase preparation system, the outer wall of the protrusion is provided with a protrusion, and the side wall of the second cavity is provided with a limiting groove for engaging with the protrusion, the limiting groove being provided with an opening to facilitate the protrusion sliding in.

[0016] Optionally, in the above-described mobile phase preparation system, the filtration module includes a filtration assembly and a negative pressure generating assembly. The filtration assembly includes a suction needle for inserting into the first channel and a drainage needle for inserting into the third channel. The negative pressure generating assembly includes a negative pressure needle for inserting into the second channel. The suction needle is used to communicate with the liquid preparation container through a suction line, the drainage needle is used to communicate with the liquid preparation container through a drainage line, and the negative pressure needle is used to connect with the vacuum source through a gas source pipe.

[0017] Optionally, in the above-described mobile phase preparation system, the filtration module further includes a driving component and a first elastic component. The driving component is used to drive the drainage needle, the negative pressure needle, and the suction needle to move toward or away from the target container. The first elastic component is respectively configured to correspond to the drainage needle, the negative pressure needle, and the suction needle. The first elastic component is used to provide a clamping force between at least one of the drainage needle, the negative pressure needle, and the suction needle and the filtration body.

[0018] Optionally, in the above-described mobile phase preparation system, the driving assembly includes a mounting plate, slide rails, and slide blocks. There are two slide rails, which are arranged parallel to each other on the mounting plate. The slide blocks are arranged corresponding to the slide rails. The negative pressure needle and the liquid extraction needle are respectively connected to the two slide blocks. A fixing seat is provided on the mounting plate. The first elastic components of the negative pressure needle and the liquid extraction needle are respectively compressed between the corresponding slide blocks and the fixing seats.

[0019] Optionally, in the above-described mobile phase preparation system, the mounting plate is further provided with a connector, and the connector is capable of driving the filtration body to move along the mounting plate toward or away from the target container. The connector is provided with a second elastic component, which is used to allow the drainage needle, the negative pressure needle and the liquid extraction needle to detach from the filtration body when moving toward or away from the target container.

[0020] Optionally, in the above-mentioned mobile phase preparation system, the liquid addition module includes a first turntable, and the feeding station is provided with a second turntable;

[0021] The first turntable includes a plurality of first transfer stations for placing the liquid dispensing container, and at least one of the first transfer stations is a first docking station that docks with the second turntable;

[0022] The second turntable includes a plurality of second transfer stations for placing the target container, and at least one of the second transfer stations is a second docking station that docks with the first turntable;

[0023] The filtration module is located between the first docking station and the second docking station. The filtration module is used to filter the liquid in the liquid preparation container located at the first docking station into the target container at the second docking station.

[0024] Optionally, in the above-described mobile phase preparation system, the liquid addition module further includes a pH adjustment component, which is disposed above the first turntable. The pH adjustment component is used to add the liquid reagent toward the liquid preparation container and detect the pH value of the liquid in the liquid preparation container.

[0025] Optionally, in the above-described mobile phase preparation system, the pH adjustment component includes a liquid addition component, a pH detection element, and a stirrer. The liquid addition component is used to add the liquid reagent into the solution preparation container. The pH detection element is used to detect the pH value of the solution in the solution preparation container and adjust the pH value of the solution in the solution preparation container through the liquid addition component. The stirrer is used to stir the solution in the solution preparation container.

[0026] Optionally, in the above-described mobile phase preparation system, the liquid addition module further includes a liquid addition and cleaning component, which is located at the center of the first turntable and is used to clean at least one of the stirrer, the pH detection element, and the liquid addition component.

[0027] Optionally, in the above-mentioned mobile phase preparation system, the liquid addition and cleaning assembly includes a first cleaning tank, a second cleaning tank, and a drying tank;

[0028] The first cleaning tank includes a waste liquid chamber and a rinsing chamber located within the waste liquid chamber. The rinsing chamber is used to clean the pH detection element, and the waste liquid chamber is used to contain the waste liquid after the rinsing chamber has cleaned the pH detection element.

[0029] The second cleaning tank is provided with a partition plate, which divides the second cleaning tank into two cleaning chambers. The two cleaning chambers are used to clean the agitator and the liquid addition assembly, respectively.

[0030] The drying tank is used to dry the agitator.

[0031] Optionally, in the above-described mobile phase preparation system, the liquid addition and cleaning assembly includes a platform protruding upward from the first turntable, the first cleaning tank, the second cleaning tank, and the drying tank are all located on one side of the platform, and a pH calibration assembly is provided on the other side of the platform, the pH calibration assembly being used to calibrate the pH detection element.

[0032] Optionally, in the above-described mobile phase preparation system, the pH calibration component includes a temperature control zone and multiple calibration containers located in the temperature control zone, the calibration containers being used to hold standard solutions for calibrating the pH detection element.

[0033] Optionally, the mobile phase preparation system described above further includes a filtration and cleaning module. The filtration and cleaning module is used to clean the filtration assembly. The filtration and cleaning module includes a cleaning liquid container, a waste liquid discharge container, and a suction module. The filtration assembly and the negative pressure generating assembly can be inserted into the suction module. The filtration assembly can be connected to the cleaning liquid container, and the suction module is connected to the waste liquid discharge container. During the cleaning operation, due to the negative pressure effect of the negative pressure generating assembly on the waste liquid discharge container, the cleaning liquid in the cleaning liquid container is drawn into the waste liquid discharge container through the filtration assembly.

[0034] The mobile phase preparation system provided in this application comprises a feeding module, a powder adding module, a liquid adding module, a filtration module, and an ultrasonic degassing module. The feeding module provides the liquid reagents required for mobile phase preparation, the powder adding module provides the powders required for mobile phase preparation, and the liquid adding module mixes the liquid reagents and powders and adjusts the pH value to obtain the prepared solution in a dispensing container. The filtration module may be equipped with a first channel connected to the dispensing container in the dispensing module and a second channel connected to a vacuum source to generate negative pressure inside the target container. This allows the prepared solution in the dispensing container to pass through the first channel and be filtered by the filtration module into the target container under the negative pressure of the target container. Furthermore, the ultrasonic degassing module degassing the liquid in the target container completes the mobile phase preparation process. As can be seen from the above examples, the mobile phase preparation system provided in this application can automatically add powder and liquid reagents and mix them. At the same time, the prepared solution can be filtered and loaded into the target container such as the mobile phase bottle through the vacuum filtration module, and the liquid in the mobile phase bottle can be degassed. This can reduce manual intervention, improve safety, and improve the efficiency and accuracy of mobile phase preparation, thus ensuring product quality.

[0035] The technical features mentioned above, those to be mentioned below, and those shown individually in the accompanying drawings can be combined arbitrarily, provided that the combined technical features are not contradictory. All feasible combinations of features are the technical content explicitly described herein. Any one of the multiple sub-features contained in the same statement can be applied independently, without necessarily being applied together with other sub-features. Attached Figure Description

[0036] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this application. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0037] Figure 1 This is a schematic diagram of the mobile phase preparation system provided in the embodiments of this application;

[0038] Figure 2 This is a partial schematic diagram of the mobile phase preparation system provided in the embodiments of this application;

[0039] Figure 3 This is a schematic diagram of the structure of the filtration module provided in an embodiment of this application;

[0040] Figure 4 An exploded view of the filtration body provided in the embodiments of this application;

[0041] Figure 5 A cross-sectional view of the filtration body provided in an embodiment of this application;

[0042] Figure 6 An isometric view of the first turntable for placing the liquid preparation container, provided in an embodiment of this application;

[0043] Figure 7 An isometric view of the first turntable provided in an embodiment of this application;

[0044] Figure 8 A top view of the first turntable provided in an embodiment of this application;

[0045] Figure 9 A cross-sectional view of the first turntable provided in an embodiment of this application;

[0046] Figure 10 This is a schematic diagram of the liquid addition and cleaning assembly provided in the embodiments of this application;

[0047] Figure 11 A schematic diagram of the structure of the filtration and cleaning module provided in the embodiments of this application. Figure 1 ;

[0048] Figure 12 A schematic diagram of the structure of the filtration and cleaning module provided in the embodiments of this application. Figure 2 .

[0049] Among them, 10 is the feeding module, 20 is the powder adding module, 201 is the transfer bin robot, 202 is the powder dispensing head storage module, 203 is the powder dispensing robot, 204 is the powder dispensing module, 30 is the liquid adding module, 301 is the first turntable, 302 is the first transfer station, 303 is the first docking station, 304 is the first rotation drive component, 305 is the supporting surface, 3051 is the guide channel, 3052 is the waste liquid outlet, 306 is the limiting part, 307 is the waste liquid tank, 3071 is the drain port, 3072 is the first base plate, 3073 is the second base plate, 308 is the liquid adding assembly, 309 is the stirrer, 310 is the pH detection component, 311 is the liquid adding and cleaning assembly, 312 is the first cleaning tank, 313 is the second cleaning tank, and 314 is the separator. Plate, 315 is the drying tank, 316 is the liquid level detection component, 317 is the connecting pipe, 318 is the platform, 319 is the pH calibration component, 320 is the temperature control zone, 321 is the calibration container, 40 is the vacuum filtration module, 401 is the first channel, 402 is the second channel, 403 is the filter membrane, 404 is the third channel, 405 is the vacuum filtration body, 406 is the vacuum filtration interface, 4061 is the vacuum filtration flow channel, 407 is the base, 4071 is the second cavity, 4071a is the stepped part, 4071b is the limiting groove, 4071c is the opening, 4072 is the vacuum filtration slot, 408 is the first connecting part, 4081 is the first cavity, 4082 is the protrusion, 4082a is the stepped surface, 4082b is the protrusion, 4082c is the second connecting part. The components are as follows: 4082d is the second pressing surface; 409 is the second connecting part; 4091 is the connecting body; 4092 is the toothed part; 4093 is the pressing part; 410 is the filter chamber; 411 is the seal; 4111 is the notch; 412 is the drainage needle; 4121 is the linear bearing; 4122 is the drainage mounting base; 4123 is the connecting base; 4124 is the drainage pipe; 413 is the negative pressure needle; 414 is the suction needle; 4141 is the flow meter; 4142 is the suction pipe; 415 is the drive assembly; 4151 is the mounting plate; 4151a is the fixed base; 4151b is the fixing part; 4151c is the track; 4152 is the slide rail; 4153 is the slide block; 4154 is the lifting drive component; and 416 is the first elastic component. 417 is the second elastic component, 418 is the connector, 4181 is the protrusion, 4181a is the mounting component, 50 is the ultrasonic degassing module, 60 is the unloading station, 601 is the second turntable, 602 is the second transfer station, 603 is the second docking station, 604 is the limiting seat, 70 is the suction cleaning module, 701 is the cleaning fluid container, 702 is the waste liquid discharge container, 703 is the suction module, 7031 is the first insertion hole, 7032 is the second insertion hole, 7033 is the third insertion hole, 7034 is the suction slot, 704 is the mounting bracket, 705 is the module placement position, 706 is the fixing plate, 80 is the opening module, 90 is the labeling module, 100 is the air drying module, 101 is the robotic arm, 200 is the workbench, and 300 is the material rack. Detailed Implementation

[0050] The core of this application is to provide a mobile phase preparation system to improve the efficiency and safety of mobile phase preparation and ensure product quality.

[0051] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0052] In related fields, the process flow for mobile phase preparation generally includes quantitative addition of powder and liquid, pH adjustment, filtration, and degassing. Some processes also require labeling of the mobile phase bottles. However, traditional mobile phase preparation is usually done manually, resulting in low mobile phase preparation efficiency, significant safety risks, and an inability to guarantee product quality stability.

[0053] Therefore, such as Figure 1 As shown in the illustration, this application discloses a mobile phase preparation system, including a feeding module 10, a powder adding module 20, a liquid adding module 30, a filtration module 40, and an ultrasonic degassing module 50 arranged along the execution direction of the process. The liquid adding module 30 enables automatic addition and mixing of powder and liquid reagents. Simultaneously, the filtration module 40 filters the prepared solution into a target container such as a mobile phase bottle, and the ultrasonic degassing module 50 degasses the liquid in the mobile phase bottle. This reduces manual intervention, improves safety, and enhances the efficiency and accuracy of mobile phase preparation, ensuring product quality.

[0054] The following will combine Figures 1 to 11 The mobile phase preparation system disclosed in the embodiments of this application will be explained and described in detail.

[0055] like Figure 1 As shown, the feeding module 10, powder adding module 20, liquid adding module 30, filtration module 40, and ultrasonic degassing module 50 of the mobile phase preparation system can all be set on the workbench 200. At the same time, a freely movable robotic arm 101 can be set on the workbench 200 to realize the transfer of materials between the various modules, thereby realizing automated production, reducing manual intervention, improving safety, and improving the efficiency and accuracy of mobile phase preparation, ensuring product quality.

[0056] like Figure 1As shown, the feeding module 10 provides liquid reagents, such as various acid and base reagents and water, for the entire mobile phase preparation. The robotic arm 101 transfers the liquid reagents from the feeding module 10 to the workstation of the liquid addition module 30, where they are mixed with the powder provided by the powder addition module 20 to prepare the formulation solution. Specifically, the feeding module 10 may include a material transport trolley, which can be located on one side of the worktable 200. Various reagents can be placed on the material transport trolley for gripping by the robotic arm 101.

[0057] like Figure 1 As shown, the powder adding module 20 can be composed of a transfer chamber robot 201, a powder dispensing head storage module 202, a powder dispensing robot 203, and a powder dispensing module 204. All three components are located in a sealed nitrogen cabinet to prevent the powder from getting damp and affecting product quality. Specifically, the transfer chamber robot 201 transports the powder adding head, weighing boat, and weights containing the powder to the nitrogen cabinet, and the powder dispensing robot 203 places the powder adding head, weighing boat, and weights onto the storage rack of the powder dispensing head storage module 202. When dispensing powder, the dispensing robot 203 first places the weights on the weighing balance of the dispensing module 204 for calibration. Then, the dispensing mechanism of the dispensing module 204 dispenses the powder from the dispensing head into the weighing boat according to the mixing ratio. The dispensing robot 203 then places the weighing boat containing the powder onto the transfer robot 201. The transfer robot 201 can then transport the weighing boat containing the powder to the station of the robot arm 101, so that the robot arm 101 can transport the weighing boat containing the powder to the station of the liquid dispensing module 30, where it can be mixed with the reagents provided by the feeding module 10 to prepare the solution. It should be noted that the transfer robot 201 can be equipped with separate placement positions for the dispensing head, the weighing boat, and the weights, so that the transfer robot 201 can stably transport the dispensing head, the weighing boat, and the weights. Meanwhile, the powder dispensing robot 203 may have gripping positions that can respectively grip the powder dispensing head, weighing boat and weight, so that the powder dispensing robot 203 can grip and transfer the powder dispensing head, weighing boat and weight.

[0058] like Figure 1 As shown, a material rack 300 can also be set on the workbench 200, and the material rack 300 has multiple loading and unloading positions. Liquid preparation containers, target containers, etc. can be placed in the loading positions of the material rack 300 so that the robotic arm 101 can grab the liquid preparation containers, target containers, etc. from the loading positions of the material rack 300. At the same time, the robotic arm 101 can place the used liquid preparation containers, etc., in the unloading positions of the material rack 300 to facilitate the unified management of used parts.

[0059] like Figure 1As shown, the liquid addition module 30 can fully mix the liquid reagent provided by the feeding module 10 and the powder provided by the powder addition module 20 in the liquid preparation container according to the ratio, and adjust the pH value of the prepared solution until the target value is reached, thus completing the preparation of the prepared solution in the liquid preparation container. Simultaneously, the liquid prepared in the liquid preparation container of the liquid addition module 30 can be filtered through the filtration module 40 to the target container located below the filtration module 40 and at the discharge station 60, thereby realizing the filtration and discharge process of the prepared solution. For example, Figure 4 and Figure 5 As shown, the filtration module 40 may include a first channel 401 connected to the liquid preparation container in the liquid addition module 30 and a second channel 402 connected to a vacuum source and capable of generating negative pressure within the target container. When filtration is required by the filtration module 40, the vacuum source can evacuate the target container through the second channel 402 to create negative pressure within the target container. This allows the liquid in the liquid preparation container to pass through the first channel 401 and be filtered by the filtration module 40 under the negative pressure of the target container before entering the target container, thus realizing the filtration process of the prepared liquid. It should be noted that the liquid preparation container can be a glass beaker with a circular or square cross-sectional shape, and the target container can be a mobile phase bottle with a circular or square cross-sectional shape.

[0060] like Figure 1 As shown, the ultrasonic degassing module 50 can degas the liquid in the target container to ensure the purity of the liquid. The ultrasonic degassing module 50 can have multiple degassing positions for the target container, and each degassing position can use a placement slot of different sizes to accommodate the degassing of liquids in target containers of different sizes. It should be noted that the ultrasonic degassing module 50 utilizes the cavitation effect generated by ultrasound waves in the liquid within the target container for degassing, and this technology is conventional and will not be elaborated upon here.

[0061] In some embodiments, such as Figure 5 As shown, a filter membrane 403 can be installed below the first channel 401 of the filtration module 40, allowing the prepared liquid in the preparation container to flow into the target container after being filtered through the filter membrane 403 via the first channel 401. Simultaneously, the second channel 402 can be connected to the target container and also to a vacuum source. This allows the vacuum source to create a vacuum inside the target container and below the first channel 401 via the second channel 402, creating a negative pressure environment. Under this negative pressure, the prepared liquid flows from the preparation container through the first channel 401 and is filtered through the filter membrane 403 before flowing into the target container. This effectively avoids the risk of the preparation container falling or colliding, ensuring high safety.

[0062] In some embodiments, such as Figure 3As shown, the target container and the liquid preparation container are connected via a liquid extraction pipe 4142. One end of the liquid extraction pipe 4142 can be inserted into the liquid preparation container, and the other end can be inserted into the first channel 401 of the filtration module 40. Simultaneously, the filtration module 40 is installed on the target container via a robotic arm 101. Furthermore, a vacuum source is inserted into the second channel 402 via a gas supply pipe. When the prepared liquid is being filtered, the vacuum source can be activated. At this time, the vacuum source can evacuate the target container and the area below the first channel 401 via the gas supply pipe, creating a negative pressure environment inside the target container and below the first channel 401. Under this negative pressure, the prepared liquid flows from the liquid preparation container through the liquid extraction pipe 4142, through the first channel 401, and through the filter membrane 403 into the target container. It should be noted that a flow meter 4141 can be installed on the liquid extraction pipeline 4142 so that the flow rate of the liquid being processed through the liquid extraction pipeline 4142 can be monitored in real time, ensuring the reliable operation of the filtration module 40.

[0063] It should be noted that in the above embodiments, the filtration module 40 can use a liquid-permeable and gas-permeable filter membrane 403, such as an acrylic copolymer membrane or a polyethersulfone (PES) filter membrane, to ensure that the vacuum source can pass through the filter membrane 403 to evacuate the lower part of the first channel 401, thereby making the lower part of the first channel 401 a negative pressure environment, ensuring that the preparation liquid can flow from the preparation container into the target container through the first channel 401 and the filter membrane 403.

[0064] In some embodiments, such as Figure 4 and Figure 5 As shown, the filtration module 40 may further include a third channel 404 and a flow-driving component. The third channel 404 can be connected to the target container and the flow-driving component, so that the preparation liquid can flow into the target container through the filter membrane 403 after being filtered by the filter membrane 403 under the drive of the flow-driving component. This makes it suitable for filter membranes 403 that are permeable to liquid but impermeable to air, such as polycarbonate (PC) membranes and nylon (PA) membranes, thereby improving the applicability of the filtration module 40.

[0065] In some embodiments, such as Figures 3 to 5As shown, when the filtration module 40 uses a liquid-permeable but air-impermeable filter membrane 403, the target container and the liquid preparation container can be connected through a drainage pipe 4124. One end of the drainage pipe 4124 can be inserted into the liquid preparation container, and the other end can be inserted into the third channel 404 of the filtration module 40. A drainage drive device, such as a peristaltic pump, can be connected to the drainage pipe 4124, and the filtration module 40 is then mounted on the target container. Furthermore, a vacuum source is connected to the second channel 402 through one end of a gas source pipe. When the prepared solution is filtered, the vacuum source and peristaltic pump can be started. At this time, the prepared solution in the preparation container flows into the space above the filter membrane 403 through the third channel 404 through the peristaltic pump via the drainage pipe 4124. At the same time, the vacuum source can evacuate the target container through the gas source pipe to make the target container a negative pressure environment. Under the action of negative pressure, the prepared solution above the filter membrane 403 can flow into the target container after being filtered by the filter membrane 403.

[0066] In some embodiments, such as Figures 3 to 5 As shown, when the filtration module 40 uses a liquid-permeable but air-impermeable filter membrane 403, the target container and the liquid preparation container can also be connected simultaneously through the liquid extraction pipe 4142 and the drainage pipe 4124. That is, one end of the liquid extraction pipe 4142 can be inserted into the liquid preparation container, and the other end of the liquid extraction pipe 4142 can be inserted into the first channel 401 of the filtration module 40. One end of the drainage pipe 4124 can be inserted into the liquid preparation container, and the other end of the drainage pipe 4124 can be inserted into the third channel 404 of the filtration module 40. The filtration module 40 is then installed on the target container, and the vacuum source is inserted into the second channel 402 through one end of the gas source pipe. When the prepared solution is filtered, the vacuum source and peristaltic pump can be started. Under the action of the peristaltic pump, the prepared solution in the preparation container flows through the drainage pipe 4124 and the third channel 404 into the space above the filter membrane 403. Simultaneously, the vacuum source can evacuate the target container through the gas source pipe, creating a negative pressure environment inside the target container. Under this negative pressure, the prepared solution above the filter membrane 403 is filtered and flows into the target container. Furthermore, if the prepared solution overflows from the space above the filter membrane 403, it can be returned to the preparation container through the liquid extraction pipe 4142, thus avoiding waste of the prepared solution and ensuring the stability of the filtration process.

[0067] In some embodiments, such as Figures 3 to 5As shown, the filtration module 40 may include a filtration body 405, and the lower end of the filtration body 405 may be provided with a filtration interface 406 that can dock and communicate with the target container. The first channel 401, the second channel 402, and the third channel 404 are all located on the upper surface of the filtration body 405, and the first channel 401 and the third channel 404 may both extend into the interior of the filtration body 405 and communicate with the filtration interface 406, thereby enabling the first channel 401 and the third channel 404 to communicate with the target container, so that the prepared liquid in the preparation container flows into the target container after being filtered through the filter membrane 403 via the first channel 401 or the third channel 404.

[0068] In some embodiments, such as Figure 4 As shown, the filtration body 405 may include a base 407, a first connecting part 408, and a second connecting part 409. The first channel 401 and the third channel 404 may both be connected through the first connecting part 408, allowing the prepared liquid in the preparation container to flow into the cavity enclosed by the first connecting part 408 and the base 407 through either the first channel 401 or the third channel 404 of the first connecting part 408. The second channel 402 may be disposed on the base 407 and may extend to communicate with the target container, thereby allowing a vacuum source to evacuate the target container and the cavity enclosed by the first connecting part 408 and the base 407, thus evacuating the target container and the cavity enclosed by the first connecting part 408. The cavity enclosed by the base part 407 is in a negative pressure environment. Under this negative pressure, the prepared liquid can flow from the preparation container into the cavity enclosed by the first connecting part 408 and the base part 407 through the first channel 401, and after being filtered by the filter membrane 403, it flows into the target container through the suction filtration port 406. Alternatively, under the action of the flow-driving component, the prepared liquid flows from the preparation container into the cavity enclosed by the first connecting part 408 and the base part 407 through the third channel 404, and under the negative pressure of the target container, it is filtered by the filter membrane 403 and then flows into the target container through the suction filtration port 406. Simultaneously, the second connecting part 409 can be sleeved on the outside of the first connecting part 408, and the second connecting part 409 and the base part 407 can be detachably connected by means of threaded connection, snap-fit, or plug-in connection, so that the second connecting part 409 presses the first connecting part 408 onto the base part 407, thereby facilitating the replacement of the filter membrane 403.

[0069] In some embodiments, such as Figure 5As shown, the filtration body 405 may have a filtration chamber 410 capable of containing the liquid to be filtered, and the filter membrane 403 may be located within the filtration chamber 410. The first connecting portion 408 may have a first cavity 4081, and the base portion 407 may have a second cavity 4071, with the first connecting portion 408 embedded within the second cavity 4071. The filtration chamber 410 may include at least the first cavity 4081 and the second cavity 4071, meaning the filtration chamber 410 may be formed by the first cavity 4081 and the second cavity 4071. Both the first channel 401 and the third channel 404 may extend into and communicate with the filtration chamber 410, allowing the liquid to flow from the dispensing container into the filtration chamber 410 through the first channel 401 or the third channel 404, be filtered by the filter membrane 403 within the filtration chamber 410, and then flow into the target container through the filtration interface 406.

[0070] In some embodiments, such as Figure 5 As shown, the outer wall of the first connecting part 408 may be provided with a protrusion 4082 facing outward. That is, the protrusion 4082 may be formed by extending from the outer wall of the first connecting part 408 in a direction away from the central axis of the first connecting part 408. The protrusion 4082 can press the filter membrane 403 in the filter chamber 410 so that the filter membrane 403 can be reliably installed in the filter chamber 410. At the same time, the side wall of the second chamber 4071 may be provided with a step part 4071a, and the protrusion 4082 is provided with a step surface 4082a that cooperates with the step part 4071a. This allows the protrusion 4082 on the outer wall of the first connecting part 408 to be pressed against the step part 4071a on the side wall of the second chamber 4071 through the step surface 4082a, thereby ensuring the sealing between the first connecting part 408 and the base part 407 and preventing the liquid in the filter chamber 410 from leaking out through the gap between the first connecting part 408 and the base part 407.

[0071] In some embodiments, such as Figure 4 and Figure 5 As shown, the cross-sectional shape of the first connecting portion 408 can be circular, and the second cavity 4071 of the base portion 407 can be adapted to the first connecting portion 408 to ensure that the first connecting portion 408 can be inserted into the second cavity 4071, thereby enabling the first cavity 4081 of the first connecting portion 408 and the second cavity 4071 of the base portion 407 to form a filter cavity 410. Simultaneously, the protrusion 4082 can be arranged circumferentially around the first connecting portion 408, and the bottom of the protrusion 4082 can form an annular stepped surface 4082a. Furthermore, the stepped portion 4071a of the sidewall of the second cavity 4071 can adopt an annular structure adapted to the stepped surface 4082a of the protrusion 4082, thereby ensuring the reliability and sealing of the connection between the first connecting portion 408 and the base portion 407.

[0072] In some embodiments, such as Figure 4 As shown, a protrusion 4082b may be provided on the outer wall of the protrusion 4082 of the first connecting part 408, and an annular limiting groove 4071b that can cooperate with the protrusion 4082b may be provided on the side wall of the second cavity 4071. At the same time, the limiting groove 4071b may be provided with an opening 4071c to facilitate the protrusion 4082b to slide in. When installing the first connecting part 408 and the base part 407, the protrusion 4082b of the first connecting part 408 can be aligned with the opening 4071c of the limiting groove 4071b and moved towards the base part 407. During the movement, the first connecting part 408 is rotated until the protrusion 4082b of the first connecting part 408 slides into the limiting groove 4071b, thereby realizing the installation and positioning of the relative position between the first connecting part 408 and the base part 407. At this time, the protrusion 4082 of the first connecting part 408 can press the filter membrane 403 in the filter chamber 410. When it is necessary to replace the filter membrane 403, simply rotate the first connecting part 408 and move it away from the base part 407 until the protrusion 4082b of the first connecting part 408 comes out from the opening 4071c. At this time, the filter membrane 403 can be replaced.

[0073] In some embodiments, such as Figure 5 As shown, the protrusion 4082 may have a first pressing surface 4082c and a second pressing surface 4082d disposed opposite to each other. The first pressing surface 4082c may abut against the filter membrane 403 in the filter cavity 410, while the second connecting part 409 may abut against the second pressing surface 4082d, so that the first connecting part 408 is pressed into the second cavity 4071 of the base part 407 by the second connecting part 409, thereby ensuring the reliability of the connection between the first connecting part 408 and the base part 407. Meanwhile, the area of ​​the first pressing surface 4082c can be smaller than the area of ​​the second pressing surface 4082d. That is, the side of the protrusion 4082 away from the second connecting part 409 can have a pressing structure with an inverted trapezoidal cross section, and the first pressing surface 4082c can be located on the side of the pressing structure away from the protrusion 4082, so as to ensure that there is a smaller contact surface between the first connecting part 408 and the filter membrane 403, thereby increasing the effective filtration surface of the filter membrane 403 and improving the filtration efficiency. It should be noted that there can be two, three or more pressing structures distributed at intervals along the circumference of the protrusion 4082, or the pressing structures can be continuously distributed along the circumference of the protrusion 4082.

[0074] In some embodiments, such as Figure 4 and Figure 5As shown, the second connecting portion 409 may include a connecting body 4091 and a toothed portion 4092 located on the connecting body 4091. The outer wall of the connecting body 4091 is provided with a pressing portion 4093, which extends away from the central axis of the connecting body 4091, so that the pressing portion 4093 can press against the second pressing surface 4082d of the protrusion 4082 of the first connecting portion 408. The pressing portion 4093 can be connected to the base portion 407, specifically, it can be a threaded connection. The side wall of the pressing portion 4093 may be provided with an external thread, and the side wall of the second cavity 4071 of the base portion 407 may be provided with an internal thread that mates with the external thread, thereby enabling the pressing portion 4093 of the second connecting portion 409 to be threadedly connected to the base portion 407.

[0075] In some embodiments, such as Figure 4 and Figure 5 As shown, the filtration module 40 may further include a sealing element 411, and a filtration channel 4061 capable of communicating with the target container is provided at the center of the filtration interface 406. Simultaneously, the sealing element 411 can be snapped onto the outside of the filtration channel 4061 to achieve a sealed connection between the filtration module 40 and the target container. Furthermore, the sidewall of the central hole of the sealing element 411 may have a notch 4111 capable of communicating with the interior of the target container, and the second channel 402 can communicate with the notch 4111, allowing a vacuum source to evacuate the target container through the second channel 402 and the notch 4111, and to evacuate the filter chamber 410 through the filtration channel 4061, thereby enabling the prepared liquid to enter the target container after being filtered through the filter membrane 403 via the first channel 401.

[0076] In some embodiments, such as Figure 4 As shown, the seal 411 may include a mounting hole, through which the suction flow channel 4061 is installed, and a portion of the mounting hole extends outward to form the aforementioned notch 4111. Thus, the structure is simple and easy to install.

[0077] In some embodiments, such as Figure 5 As shown, the bottom wall of the second cavity 4071 can be provided with multiple flow channels, and each flow channel can be radially distributed around the filtration interface 406 and communicate with the filtration interface 406. At the same time, the filter membrane 403 is laid on top of each flow channel, so that the prepared liquid can flow into the filtration interface 406 through the flow channel after being filtered by the filter membrane 403, and then flow into the target container through the filtration channel 4061. The bottom of the flow channel can be inclined towards the filtration interface 406, that is, the end of the bottom of the flow channel away from the filtration interface 406 is higher than the end of the bottom of the flow channel near the filtration interface 406, which facilitates the rapid flow of the filtered prepared liquid into the target container and avoids residual liquid remaining in the flow channel.

[0078] In some embodiments, such as Figure 3 As shown, the filtration module 40 may include a filtration assembly and a negative pressure generating assembly. The filtration assembly may include a suction needle 414 that can be inserted into the first channel 401 and a drainage needle 412 that can be inserted into the third channel 404. The negative pressure generating assembly may include a negative pressure needle 413 that can be inserted into the second channel 402. The suction needle 414 can be connected to the liquid preparation container via a suction pipe 4142, while the negative pressure needle 413 can be connected to a vacuum source via a gas source pipe. This generates negative pressure within the target container located below the filtration body 405. Under this negative pressure, the prepared liquid flows from the liquid preparation container through the suction needle 414, through the filtration body 405, and into the target container after filtration. This effectively avoids the risk of the liquid preparation container falling or colliding, ensuring high safety. Furthermore, the drainage needle 412 can be connected to the liquid preparation container via the drainage tube 4124. One end of the drainage tube 4124 is connected to the liquid preparation container, and the other end is connected to a peristaltic pump or other drainage drive component, which is also connected to the drainage needle 412. When the prepared liquid in the liquid preparation container cannot flow from the container into the filtration body 405 through the suction needle 414 under negative pressure, the vacuum source and the peristaltic pump or other drainage drive component can be activated simultaneously. Driven by the drainage drive component, the prepared liquid can flow from the drainage needle 412 into the filtration body 405, and after filtration by the filtration body 405, flow into the target container.

[0079] In some embodiments, such as Figure 3As shown, the filtration module 40 may further include a driving component 415 and a first elastic component 416. The driving component 415 can simultaneously drive the drainage needle 412, the negative pressure needle 413, and the suction needle 414 to move towards or away from the target container. That is, the drainage needle 412, the negative pressure needle 413, and the suction needle 414 can share a single driving component 415 for lifting and lowering. To ensure the sealing of the drainage needle 412, the negative pressure needle 413, and the suction needle 414 when inserted into the filtration body 405, and to avoid incomplete insertion during the insertion process, resulting in a poor seal, the first elastic component 416 can be respectively configured corresponding to the drainage needle 412, the negative pressure needle 413, and the suction needle 414. That is, each of the drainage needle 412, the negative pressure needle 413, and the suction needle 414 can be respectively equipped with a first elastic component 416, thereby allowing the first elastic component 416 to... The first elastic component 416 can provide a clamping force between at least one of the drainage needle 412, negative pressure needle 413, and liquid extraction needle 414 and the filtration body 405. That is, the first elastic component 416 can provide a clamping force for one of the drainage needle 412, negative pressure needle 413, and liquid extraction needle 414, or it can provide a clamping force for two or three of them at the same time, so as to ensure that the drainage needle 412, negative pressure needle 413, and liquid extraction needle 414 can all be inserted into the target depth of the filtration body 405 under the elastic force of the first elastic component 416. This can ensure the sealing of the drainage needle 412, negative pressure needle 413, and liquid extraction needle 414 when they are inserted into the filtration body 405, prevent leakage of liquid and air, and ensure the reliability and stability of the filtration body 405 in filtration the liquid in the liquid preparation container into the target container. It should be noted that, because the drainage needle 412, negative pressure needle 413, and suction needle 414 have a certain taper, they need to be inserted into the filtration body 405 to the target depth to ensure a sealed connection between the drainage needle 412, negative pressure needle 413, and suction needle 414 and the filtration body 405. The first elastic component 416 can be a compression spring, etc.

[0080] In some embodiments, such as Figure 3As shown, a linear bearing 4121 can be sleeved on the outer side of the drainage needle 412, and the linear bearing 4121 and the outer peripheral surface of the drainage needle 412 can be clearance-fitted so that the drainage needle 412 can move along the linear bearing 4121, thereby providing a guiding effect for the raising and lowering of the drainage needle 412 through the linear bearing 4121. Meanwhile, a drainage mounting seat 4122 can be provided on the drainage needle 412, and the drainage mounting seat 4122 can be fixedly connected to the drainage needle 412. The first elastic component 416 of the drainage needle 412 is compressed between the drainage mounting seat 4122 and the linear bearing 4121. That is, the first elastic component 416 can be sleeved on the outside of the drainage needle 412, and one end of the first elastic component 416 can abut against the lower end face of the linear bearing 4121, and the other end of the first elastic component 416 can abut against the drainage mounting seat 4122. Thus, the first elastic component 416 can be compressed between the drainage mounting seat 4122 and the linear bearing 4121, so that the first elastic component 416 can provide a clamping force to the drainage needle 412 through the drainage mounting seat 4122, ensuring that the drainage needle 412 is inserted in place and preventing leakage.

[0081] In some embodiments, such as Figure 3As shown, the drive assembly 415 may include a mounting plate 4151, a slide rail 4152, and a slide block 4153. The mounting plate 4151 can be connected to a lifting drive component 4154, allowing the lifting drive component 4154 to drive the mounting plate 4151 to perform lifting actions. Two slide rails 4152 can be used, and the two slide rails 4152 can be installed parallel to each other on the mounting plate 4151. The slide blocks 4153 are correspondingly arranged with the slide rails 4152, meaning that one slide block 4153 can be provided on each slide rail 4152. The slide blocks 4153 can slide along the slide rails 4152. The negative pressure needle 413 and the aspiration needle 414 can be connected to the two slide blocks 4153 respectively, thereby providing a more stable guiding effect for the movement of the negative pressure needle 413 and the aspiration needle 414 through the slide rails 4152. Furthermore, a fixing seat 4151a can be fixed to the mounting plate 4151 by fasteners such as bolts, and the fixing seat 4151a is located on the top of the slide rail 4152. The first elastic components 416 of the negative pressure needle 413 and the aspiration needle 414 can be compressed between the corresponding slide 4153 and the fixing seat 4151a, respectively. That is, one end of the first elastic component 416 of the negative pressure needle 413 can abut against the fixing seat 4151a, and the other end of the first elastic component 416 of the negative pressure needle 413 can abut against the negative pressure needle. On the slide 4153 of 413, similarly, one end of the first elastic component 416 of the aspiration needle 414 can abut against the fixed seat 4151a, and the other end of the first elastic component 416 of the aspiration needle 414 can abut against the slide 4153 of the aspiration needle 414, so that the two first elastic components 416 can respectively provide clamping force to the negative pressure needle 413 and the aspiration needle 414 through the two slides 4153, ensuring that the negative pressure needle 413 and the aspiration needle 414 are inserted in place, and preventing air leakage and liquid leakage.

[0082] In some embodiments, such as Figure 3 As shown, the drainage needle 412 and the suction needle 414 can be mounted on the same slide 4153, so that the mounting plate 4151 can simultaneously drive the drainage needle 412 to move. The drainage needle 412 can be mounted on the connecting seat 4123, and the connecting seat 4123 can be provided with at least one vertically oriented strip hole (one, two, or more). Simultaneously, the slide 4153 of the suction needle 414 can be provided with a fixing hole that mates with the strip hole, allowing for locking and fixing by bolts or other fasteners passing sequentially through the strip hole on the connecting seat 4123 and the fixing hole on the slide 4153. The vertical height of the drainage needle 412 can be adjusted through the strip hole on the connecting seat 4123, ensuring that the drainage needle 412 and the suction needle 414 can be simultaneously inserted into the filtration body 405.

[0083] In some embodiments, such as Figure 3As shown, the lifting drive component 4154 can be a screw motor, lifting cylinder, lifting hydraulic cylinder, etc., and the lifting drive component 4154 is equipped with a lifting seat that can be raised and lowered. The lifting seat can be connected and fixed to the side of the mounting plate 4151 away from the slide rail 4152 and the slide 4153 by bolts or other fasteners through a Z-shaped connecting plate. The lifting drive component 4154 drives the lifting seat to rise and fall, thereby realizing the lifting action of the drainage needle 412, negative pressure needle 413 and liquid suction needle 414 driven by the mounting plate 4151, thereby realizing the movement towards or away from the target container.

[0084] In some embodiments, such as Figure 3 As shown, a connector 418 may also be provided on the mounting plate 4151. The connector 418 can drive the filtration body 405 to move along the mounting plate 4151 toward or away from the target container. Simultaneously, a second elastic component 417 may be provided on the connector 418, allowing the drainage needle 412, negative pressure needle 413, and suction needle 414 to quickly detach from the filtration body 405 when moving away from the target container under the elastic force of the second elastic component 417. It should be noted that the second elastic component 417 may be a compression spring or similar material.

[0085] In some embodiments, such as Figure 3 As shown, filter slots 4072 can be provided on opposite sides of the filter body 405. Specifically, the filter slots 4072 can be provided on opposite sides of the base part 407. Meanwhile, the connector 418 can include two protrusions 4181 that mate with the filter slots 4072, allowing the protrusions 4181 to be inserted into the filter slots 4072 to achieve the installation and fixation of the connector 418 and the filter body 405. Simultaneously, a mounting member 4181a for mounting the second elastic component 417 is provided on the protrusion 4181, and a fixing member 4151b can be fixed on the mounting plate 4151 with bolts or other fasteners, so that one end of the second elastic component 417 can abut against the mounting member 4181a of the protrusion 4181, and the other end of the second elastic component 417 can abut against the fixing member 4151b, thereby achieving the installation and fixation of the second elastic component 417.

[0086] In some embodiments, such as Figure 3As shown, a vertical track 4151c can be provided on the mounting plate 4151, and the fixing member 4151b can be located on one side of the track 4151c. At the same time, the connecting member 418 can move along the track 4151c to provide guidance for the movement of the filtration body 405. When the drainage needle 412, the negative pressure needle 413, and the liquid extraction needle 414 move away from the target container, the second elastic component 417 can apply a spring force to the filtration body 405 through the connecting member 418 in the opposite direction to the movement of the drainage needle 412, the negative pressure needle 413, and the liquid extraction needle 414. Thus, under the action of the spring force of the second elastic component 417, the drainage needle 412, the negative pressure needle 413, and the liquid extraction needle 414 can quickly detach from the filtration body 405 when moving away from the target container.

[0087] In some embodiments, such as Figure 11 and Figure 12 As shown, the mobile phase preparation system may further include a filtration and cleaning module 70. This module cleans the filtration assembly, effectively removing residues from the previous liquid application and fundamentally preventing cross-contamination between different applications, thus ensuring the purity of the prepared solution. The filtration and cleaning module 70 may include a cleaning liquid container 701, a waste liquid discharge container 702, and a suction module 703. The suction module 703 is connected to the waste liquid discharge container 702. The filtration assembly and a negative pressure generating component can be inserted into the suction module 703, and the filtration assembly is connected to the cleaning liquid container 701. When cleaning the filtration assembly, the suction module 703 is connected to the waste liquid discharge container 702, and the filtration assembly and negative pressure generating component are inserted into the suction module 703. During the cleaning operation, the negative pressure exerted by the negative pressure generating component on the waste liquid discharge container 702 causes the cleaning liquid in the cleaning liquid container 701 to be drawn into the waste liquid discharge container 702 through the filtration assembly, thereby cleaning the filtration assembly.

[0088] In some embodiments, such as Figure 11 As shown, when cleaning the suction needle 414 and suction pipe 4142 of the filtration assembly, the suction module 703 can be connected to the waste liquid discharge container 702, and the suction needle 414 and the negative pressure needle 413 of the negative pressure generating component are simultaneously inserted into the suction module 703. The suction needle 414 is connected to the cleaning liquid container 701 through the suction pipe 4142, so that under the action of negative pressure in the waste liquid discharge container 702, the cleaning liquid in the cleaning liquid container 701 is sucked into the waste liquid discharge container 702 through the suction needle 414 and suction pipe 4142 of the filtration assembly, so as to achieve cleaning of the suction needle 414 and suction pipe 4142.

[0089] In some embodiments, such as Figure 11As shown, when cleaning the drainage needle 412 and drainage pipe 4124 of the filtration assembly, the suction module 703 can be connected to the waste liquid discharge container 702, and the drainage needle 412 is inserted into the suction module 703. At the same time, the drainage needle 412 is connected to the cleaning liquid container 701 through the drainage pipe 4124. At this time, the peristaltic pump and other drainage driving components are started so that the cleaning liquid in the cleaning liquid container 701 can flow into the waste liquid discharge container 702 through the drainage pipe 4124 and the drainage needle 412 under the action of the peristaltic pump and other drainage driving components, thereby realizing the cleaning of the drainage needle 412 and the drainage pipe 4124.

[0090] In some embodiments, the cleaning fluid container 701 may include a cleaning tank and a waste liquid tank, wherein the cleaning tank may contain cleaning fluid such as clean water, and the waste liquid tank may be used to hold waste liquid after cleaning. The suction needle 414 may be connected to the waste liquid tank through the suction pipe 4142, and the drainage needle 412 may be connected to the cleaning tank through the drainage pipe 4124. When cleaning the filtration assembly, the suction module 703 can be connected to the waste liquid discharge container 702. At the same time, the suction needle 414 is inserted into the suction module 703 and is connected to the waste liquid tank through the suction pipe 4142. The drainage needle 412 is inserted into the suction module 703 and is connected to the cleaning tank through the drainage pipe 4124. This allows the liquid in the cleaning tank to be introduced into the suction module 703 through the drainage pipe 4124 and the drainage needle 412 under the driving action of the drainage drive component, and then flow back to the waste liquid tank through the suction needle 414 and the suction pipe 4142. This allows for simultaneous cleaning of the suction needle 414, the suction pipe 4142, the drainage needle 412, and the drainage pipe 4124, improving cleaning efficiency.

[0091] In some embodiments, the cleaning fluid container 701 may also include an air blowing element, which can blow air into the liquid extraction line 4142 and the drainage line 4124, thereby drying the water stains remaining in the liquid extraction line 4142 and the drainage line 4124, fundamentally avoiding cross-contamination between different times and ensuring the purity of the prepared solution.

[0092] In some embodiments, such as Figure 11 and Figure 12As shown, the upper end face of the suction module 703 may be provided with a first insertion hole 7031 for inserting a suction needle 414, a second insertion hole 7032 for inserting a negative pressure needle 413, and a third insertion hole 7033 for inserting a drainage needle 412. At the same time, the lower end of the suction module 703 may be provided with a cleaning interface that can connect with the waste liquid discharge container 702. The first insertion hole 7031 and the third insertion hole 7033 can extend into the interior of the suction module 703 and communicate with the cleaning interface. Thus, the cleaning liquid after cleaning the filtration component can be directly and tightly introduced into the waste liquid discharge container 702 through the first insertion hole 7031 or the third insertion hole 7033 via the suction module 703 for centralized treatment, avoiding pollution of operators and experimental environment by chemical reagents, and making it safer and more environmentally friendly.

[0093] In some embodiments, such as Figure 11 and Figure 12 As shown, the mobile phase preparation system may further include a mounting frame 704, and the mounting frame 704 is provided with a module placement position 705 for placing the suction module 703. The suction module 703 can be moved between the module placement position 705 and the waste liquid discharge container 702 by the robotic arm 101. When cleaning the filtration assembly, the suction needle 414, the drainage needle 412, and the negative pressure needle 413 can all detach from the filtration body 405 and be inserted into the first insertion hole 7031, the third insertion hole 7033, and the second insertion hole 7032 of the suction module 703, respectively. The suction module 703 moves to the waste liquid discharge container 702 and connects with the waste liquid discharge container 702 through the cleaning interface, thereby realizing the cleaning of the filtration assembly.

[0094] In some embodiments, such as Figure 11 As shown, suction modules 703 have suction slots 7034 on opposite sides, allowing the protrusions 4181 of connectors 418 to be inserted into the suction slots 7034, thereby securing the suction module 703. Meanwhile, as... Figure 11 and Figure 12 As shown, two fixing plates 706 that can cooperate with the suction slot 7034 can be provided on the module placement position 705 so that the fixing plates 706 can be inserted into the suction slot 7034, and the suction module 703 can be stably placed on the module placement position 705.

[0095] It should be noted that the structure of the suction module 703 is similar to that of the filtration body 405. The difference between the suction module 703 and the filtration body 405 is whether or not a filter membrane 403 is provided. That is, the suction module 703 does not need to be equipped with a filter membrane 403, while the filtration body 405 needs to be equipped with a filter membrane 403 to achieve the filtration effect. For the same or similar structures between the suction module 703 and the filtration body 405, please refer to the explanation and description of the filtration body 405 above. It will not be repeated here.

[0096] In some embodiments, such as Figure 1 and Figure 2 As shown, the liquid addition module 30 may include a first turntable 301, and a second turntable 601 may be provided at the unloading station 60. The first turntable 301 may have multiple first transfer stations 302 for placing liquid dispensing containers; that is, two, three, or more first transfer stations 302 may be used, and each first transfer station 302 may be distributed circumferentially along the first turntable 301. At least one of the first transfer stations 302 is a first docking station 303 that docks with the second turntable 601; that is, each first transfer station 302 may have one, two, or more first docking stations 303 capable of docking with the second turntable 601. Meanwhile, as... Figure 2 As shown, the second turntable 601 can be provided with multiple second transfer stations 602 capable of placing target containers. That is, there can be two, three, or more second transfer stations 602, and each second transfer station 602 can be distributed circumferentially along the second turntable 601. At least one of the second transfer stations 602 is a second docking station 603 that docks with the first turntable 301. When it is necessary to transfer the prepared liquid from the dispensing container to the target container, the first docking station 303 of the first turntable 301 and the second docking station 603 of the second turntable 601 can be rotated to an aligned state, meaning the first docking station 303 and the second docking station 603 can be located on the same axis, thereby allowing the prepared liquid to be transferred through the filtration module 40.

[0097] In some embodiments, such as Figure 2 As shown, the filtration module 40 can be located between the first docking station 303 and the second docking station 603, thereby allowing the liquid in the dispensing container at the first docking station 303 to be filtered into the target container at the second docking station 603. Furthermore, placing the filtration module 40 between the first docking station 303 and the second docking station 603 shortens the liquid transfer path, improves the transfer efficiency, and avoids the risk of the dispensing container falling or colliding when transferred to the target container via the transfer mechanism. It also eliminates the need for a separate transfer mechanism, reducing the overall size of the equipment and resulting in a more compact structure and higher space utilization.

[0098] In some embodiments, such as Figure 6 and Figure 7As shown, the first turntable 301 may include a first rotation drive 304, which can drive each first transfer station 302 to rotate, so that the first docking station 303 rotates to be aligned with the second docking station 603, that is, the first docking station 303 and the second docking station 603 are located on the same axis. Specifically, the first rotation drive 304 may be a servo motor, and the servo motor may be located below the first turntable 301, so that the first turntable 301 can be driven to rotate by the servo motor, so that the first docking station 303 rotates to be aligned with the second docking station 603, thereby facilitating the transfer of the preparation liquid by the filtration module 40.

[0099] In some embodiments, such as Figure 6 As shown, the first transfer station 302 can be tilted so that the bottom of the liquid preparation container can be raised at a certain angle, such as 5° or 10°, so that the liquid in the liquid preparation container can flow in a preset direction and gather at the corner or one side of the liquid preparation container, so that it can be better transferred to the target container by the filtration module 40. This can avoid the phenomenon of a lot of liquid preparation remaining in the liquid preparation container and reduce the workload of waste liquid treatment. It should be noted that the preset direction can be the radial direction of the first turntable 301, and the height of the outer side of the first transfer station 302 is greater than the height of the inner side of the first transfer station 302. That is, the liquid in the liquid preparation container can flow towards the inner side of the first turntable 301 in the radial direction, so that the liquid in the liquid preparation container can gather at the inner corner or inner side of the liquid preparation container. Of course, the height of the outer side of the first transfer station 302 can also be less than the height of the inner side of the first transfer station 302. That is, the liquid in the liquid preparation container can flow towards the outer side of the first turntable 301 in the radial direction, so that the liquid in the liquid preparation container can gather at the outer corner or outer side of the liquid preparation container. This makes it easier for the filtration module 40 to transfer the liquid to the target container, thereby avoiding the phenomenon of a lot of liquid preparation remaining in the liquid preparation container and reducing the workload of waste liquid treatment.

[0100] In some embodiments, such as Figures 7 to 9As shown, the first transfer station 302 may include a support surface 305 capable of supporting the liquid preparation container. The support surface 305 may be inclined along the radial direction of the first turntable 301, that is, the height of the inner side of the support surface 305 may be greater than the height of the outer side of the support surface 305, so that the inner side of the liquid preparation container can be raised, thereby allowing the liquid in the liquid preparation container to flow and converge along the radial direction of the first turntable 301 towards the outer side of the first turntable 301. This facilitates better transfer by the filtration module 40 to the target container, avoiding the phenomenon of excessive liquid residue in the liquid preparation container. At the same time, the support surface 305 may be provided with a guide channel 3051 and a waste liquid outlet 3052, and the guide channel 3051 is connected to the waste liquid outlet 3052. When the mixing container is damaged, some of the waste liquid inside the mixing container can flow to the waste liquid outlet 3052 through the guide channel 3051, and some waste liquid can flow directly from the support surface 305 to the waste liquid outlet 3052 and be discharged from the waste liquid outlet 3052, so as to prevent the waste liquid in the mixing container from contaminating the support surface 305 and affecting the subsequent placement of the mixing container. It should be noted that the waste liquid referred to in this embodiment includes the liquid leaking from the mixing container when the mixing container is damaged, and also includes the liquid dripping outside the mixing container due to operational errors.

[0101] In some embodiments, such as Figure 8 As shown, multiple guide channels 3051 can be used, i.e., two, three, or more guide channels 3051 can be used, and each guide channel 3051 can be radially distributed around the waste liquid outlet 3052. The waste liquid outlet 3052 can be located at the center of the supporting surface 305, and one end of the guide channel 3051 can be connected to the waste liquid outlet 3052, while the other end of the guide channel 3051 can extend to the edge of the supporting surface 305. Simultaneously, the cross-sectional shape of the guide channel 3051 can be an inverted trapezoidal cross-section, a triangular cross-section, etc., so that the waste liquid on the supporting surface 305 can flow from the guide channel 3051 into the waste liquid outlet 3052 under the guidance of the inclined sidewall of the guide channel 3051, thereby preventing residual waste liquid from adhering to the sidewall of the guide channel 3051.

[0102] In some embodiments, such as Figures 7 to 9 As shown, the first transfer station 302 may further include a limiting part 306, which may be disposed around the edge of the supporting surface 305, so that the liquid dispensing container can be positioned by the limiting part 306, and the displacement of the liquid dispensing container can be limited. In addition, when the liquid dispensing container is damaged, the limiting part 306 can prevent the waste liquid on the supporting surface 305 from overflowing, that is, the limiting part 306 can block the waste liquid on the supporting surface 305 within the space enclosed by the limiting part 306.

[0103] In some embodiments, such as Figure 9As shown, a waste liquid tank 307 may be provided at the bottom of the first turntable 301, and the waste liquid tank 307 may be distributed circumferentially along the first turntable 301. Simultaneously, the waste liquid outlet 3052 may extend towards the side away from the support surface 305 and communicate with the waste liquid tank 307, so that the waste liquid outlet 3052 can discharge the waste liquid in the guide channel 3051 and on the support surface 305 into the waste liquid tank 307. Furthermore, a drain port 3071 may be provided at the bottom of the waste liquid tank 307, so that the waste liquid in the waste liquid tank 307 can be discharged into the waste liquid collector through the drain port 3071, preventing waste liquid pollution.

[0104] In some embodiments, such as Figure 9 As shown, the waste liquid outlet 3052 can have a large-diameter end and a small-diameter end, and the diameter of the waste liquid outlet 3052 gradually decreases from the large-diameter end to the small-diameter end to form a funnel-shaped structure. Simultaneously, the large-diameter end of the waste liquid outlet 3052 can be located on the supporting surface 305, and the small-diameter end of the waste liquid outlet 3052 can extend into the waste liquid tank 307 to prevent waste liquid from splashing onto the outside of the waste liquid tank 307. By adopting a funnel-shaped structure for the waste liquid outlet 3052, waste liquid can be prevented from adhering to the side wall of the waste liquid outlet 3052, and it can also guide the waste liquid into the waste liquid tank 307, ensuring that the waste liquid can smoothly enter the waste liquid tank 307.

[0105] In some embodiments, such as Figure 9 As shown, the bottom wall of the waste liquid tank 307 can adopt a double-layer plate structure. The bottom wall of the waste liquid tank 307 may include a first bottom plate 3072 and a second bottom plate 3073, and the first bottom plate 3072 can be located above the second bottom plate 3073. At the same time, the first bottom plate 3072 can be inclined so that the waste liquid in the waste liquid tank 307 flows towards the drain port 3071, so as to reduce the waste liquid residue in the waste liquid tank 307. In addition, the second bottom plate 3073 can be arranged horizontally, which facilitates the installation of the first turntable 301 on the workbench 200.

[0106] In some embodiments, such as Figure 9 As shown, the drain outlet 3071 can be located near the outer wall of the waste liquid tank 307, meaning the distance between the drain outlet 3071 and the outer wall of the waste liquid tank 307 is less than the distance between the drain outlet 3071 and the inner wall of the waste liquid tank 307. Simultaneously, the first base plate 3072 is inclined towards the drain outlet 3071, meaning the inner side of the first base plate 3072 is higher than its outer side, allowing the waste liquid on the first base plate 3072 to flow into the drain outlet 3071 and be discharged into the waste liquid collector through the drain outlet 3071. One drain outlet 3071 can be provided, or multiple drain outlets 3071 can be spaced apart along the circumference of the waste liquid tank 307 to improve the discharge efficiency of the waste liquid in the waste liquid tank 307.

[0107] In some embodiments, such as Figure 6As shown, the liquid addition module 30 may also include a pH adjustment component, which may be positioned above the first turntable 301 to add liquid reagents toward the liquid preparation container and detect the pH value of the liquid in the liquid preparation container.

[0108] In some embodiments, such as Figure 6 As shown, the pH adjustment component may include a liquid addition component 308, a pH detection element 310, and a stirrer 309. Liquid reagents can be added into the preparation container via the liquid addition component 308, and the stirrer 309 agitates the preparation solution in the container to ensure thorough mixing. Simultaneously, the pH value of the preparation solution in the container can be detected by the pH detection element 310, and the pH value can be adjusted via the liquid addition component 308 until a suitable pH preparation solution is obtained.

[0109] In some embodiments, such as Figure 6 As shown, the liquid addition assembly 308 can move horizontally and vertically, thereby adding liquid reagents into the liquid preparation container. Specifically, the liquid addition assembly 308 can move horizontally and vertically under the drive of the X-axis displacement drive mechanism, the Y-axis displacement drive mechanism, and the Z-axis displacement drive mechanism, respectively, thereby sequentially adding the preparation solution to each liquid preparation container. After the liquid addition assembly 308 has added the preparation solution to the liquid preparation container at one of the first transfer stations 302, the first turntable 301 can be rotated to switch to the liquid preparation container at the next first transfer station 302, thereby adding the preparation solution to the liquid preparation container through the liquid addition assembly 308. Of course, the X-axis displacement drive mechanism and the Y-axis displacement drive mechanism can also be used to drive the liquid addition assembly 308 to switch between liquid preparation containers at different first transfer stations 302 for liquid addition.

[0110] It should be noted that in the above embodiments, the liquid addition assembly 308 may include multiple injection needles, that is, two, three or more injection needles may be used to add a variety of acid and base reagents to the liquid preparation container.

[0111] In some embodiments, such as Figure 6 As shown, the stirrer 309 and the pH detection element 310 can both move horizontally and vertically under the driving action of the X-axis displacement drive mechanism, the Y-axis displacement drive mechanism and the Z-axis displacement drive mechanism, thereby realizing the stirring and pH detection of the prepared liquid in each liquid preparation container. Of course, the first turntable 301 can also be rotated to switch the liquid preparation containers of each first transfer station 302, thereby realizing the stirring and pH detection of the prepared liquid in each liquid preparation container by the stirrer 309 and the pH detection element 310.

[0112] It should be noted that in the above embodiments, the stirrer 309 can be a motor-driven stirring paddle, so that the stirring paddle can be rotated by the motor to stir the preparation liquid in the preparation container and ensure that the preparation liquid in the preparation container is fully mixed. At the same time, the pH detection element 310 can be a pH meter, and the pH electrode of the pH meter can be inserted into the preparation liquid in the preparation container to detect the pH value of the preparation liquid in the preparation container.

[0113] In some embodiments, such as Figures 6 to 10 As shown, the liquid addition module 30 may further include a liquid addition cleaning component 311, which is located at the center of the first turntable 301. The liquid addition cleaning component 311 can clean at least one of the stirrer 309, the pH sensor 310, and the liquid addition component 308. Specifically, the liquid addition cleaning component 311 can clean one of the stirrer 309, the pH sensor 310, and the liquid addition component 308, or it can clean two or more of these components to prevent residual liquid on at least one of the stirrer 309, the pH sensor 310, and the liquid addition component 308 from affecting the prepared liquid in the mixing container.

[0114] In some embodiments, such as Figure 7 , Figure 8 and Figure 10As shown, the liquid addition cleaning assembly 311 may include a first cleaning tank 312, a second cleaning tank 313, and a drying tank 315. The first cleaning tank 312 may include a waste liquid chamber and a rinsing chamber located within the waste liquid chamber. The pH sensor 310 can extend into the rinsing chamber to clean the pH sensor 310. Simultaneously, the waste liquid chamber can hold the waste liquid from cleaning the pH sensor 310. In this embodiment, the rinsing chamber can be connected to a water injection device to continuously inject water into the rinsing chamber, allowing the rinsing chamber to rinse the pH sensor 310. Simultaneously, the wastewater in the rinsing chamber can overflow into the outer waste liquid chamber. The second cleaning tank 313 may be provided with a partition plate 314, thereby dividing the second cleaning tank 313 into two cleaning chambers, allowing the two cleaning chambers to respectively clean the agitator 309 and the liquid addition assembly 308. For ease of understanding, the cleaning chamber of the agitator 309 is defined as the first cleaning chamber, and the cleaning chamber of the liquid dosing assembly 308 is defined as the second cleaning chamber. The first cleaning chamber can be connected to a water injection device, and the agitator 309 can extend into the first cleaning chamber to achieve the cleaning process of the agitator 309. At the same time, the wastewater in the first cleaning chamber can overflow into the second cleaning chamber. After the agitator 309 is cleaned, it can be extended into the drying tank 315 for drying. When lubricating the liquid dosing needles of the liquid dosing assembly 308 with reagents, the reagent in the liquid dosing assembly 308 can flow into the second cleaning chamber, so that the reagent after cleaning the liquid dosing needles of the liquid dosing assembly 308 can be collected through the second cleaning chamber to achieve the cleaning process of the liquid dosing assembly 308. It should be noted that two hot air blowers can be installed in the drying tank 315, and the air outlets of the two hot air blowers are arranged opposite each other so that the two hot air blowers can blow air towards both sides of the agitator 309, thereby improving the drying efficiency of the agitator 309.

[0115] In some embodiments, such as Figure 9As shown, the liquid addition cleaning assembly 311 may further include a liquid level detection assembly 316, which can detect the liquid level in the waste liquid chamber. The liquid level detection assembly 316 may include a connecting pipe 317 and a liquid level detection element. The connecting pipe 317 may be vertically disposed on the outside of the first cleaning tank 312, and the outer wall of the waste liquid chamber has a first port and a second port respectively communicating with the waste liquid chamber. The second port is located above the first port. Both ends of the connecting pipe 317 may be connected to the first port and the second port respectively, and the liquid level detection element may be disposed on the connecting pipe 317 to detect the liquid level in the connecting pipe 317, thereby enabling the detection of the liquid level in the waste liquid chamber. Alternatively, the liquid level detection assembly 316 may also be disposed on the first cleaning chamber to detect the liquid level within the first cleaning chamber. It should be noted that the liquid level detection element may be a liquid level sensor, which can be used to detect the liquid level in the connecting pipe 317, thereby enabling the detection of the liquid level in the waste liquid chamber.

[0116] In some embodiments, a baffle may also be provided in the waste liquid chamber to block the second port, thereby preventing liquid in the flushing chamber from flowing into the second port and reducing the accuracy of the liquid level detection element in measuring the liquid level.

[0117] In some embodiments, such as Figures 6 to 9 As shown, the liquid addition cleaning assembly 311 may include a platform 318, and the platform 318 may be located at the center of the first turntable 301 and protrude above the first turntable 301. Wherein, as Figure 8 and Figure 10 As shown, the first cleaning tank 312, the second cleaning tank 313 and the drying tank 315 can all be located on one side of the platform 318. Meanwhile, a pH calibration component 319 can be provided on the other side of the platform 318 to calibrate the pH detection element 310, thereby reducing the detection error of the pH detection element 310.

[0118] In some embodiments, such as Figure 7 , Figure 8 and Figure 10 As shown, the pH calibration component 319 may include a temperature control zone 320 and multiple calibration containers 321 located in the temperature control zone 320. The calibration containers 321 may contain standard solutions for calibrating the pH detection element 310. The temperature of the standard solution in the calibration container 321 can be controlled by the temperature control zone 320. The pH detection element 310 is sequentially inserted into the standard solution in each calibration container 321. The pH value detected by the pH detection element 310 is compared with the actual pH value of the standard solution, thereby realizing the calibration process of the pH detection element 310.

[0119] In some embodiments, such as Figure 2As shown, the second turntable 601 may include a second rotation drive, which can drive each of the second transfer stations 602 to rotate, so that the second docking station 603 rotates to be aligned with the first docking station 303, that is, the second docking station 603 and the first docking station 303 are located on the same axis. Specifically, the second rotation drive can be a servo motor, and the servo motor can be located below the second turntable 601, so that the second turntable 601 can be driven to rotate by the servo motor, so that the second docking station 603 rotates to be aligned with the first docking station 303, thereby facilitating the transfer of the preparation liquid by the filtration module 40.

[0120] In some embodiments, such as Figure 2 As shown, a limiting seat 604 can be provided on the second transfer station 602, and the target container can be placed on the limiting seat 604 so that the target container can be positioned through the limiting seat 604, and the movement of the target container can be restricted. Specifically, the limiting seat 604 may include a limiting plate, and the limiting plate surrounds a placement space for placing the target container, so that the target container can be placed in the placement space and limited by the limiting plate.

[0121] It should be noted that the mobile phase preparation system can be composed of multiple interconnected modular units. In addition, one or more of the following modules can be set on each modular unit according to actual needs: feeding module 10, powder adding module 20, liquid adding module 30, filtration module 40, and ultrasonic degassing module 50. This can meet different mobile phase preparation needs and improve the adaptability of the mobile phase preparation system.

[0122] The mobile phase preparation system disclosed in this application comprises a feeding module 10, a powder adding module 20, a liquid adding module 30, a filtration module 40, and an ultrasonic degassing module 50. The feeding module 10 provides the liquid reagents required for mobile phase preparation, the powder adding module 20 provides the powders required for mobile phase preparation, and the liquid adding module 30 mixes the liquid reagents and powders and adjusts the pH value to obtain a prepared solution in a mixing container. The filtration module 40 may be provided with a first channel 401 connected to the mixing container in the liquid adding module 30 and a second channel 402 connected to a vacuum source to generate negative pressure inside the target container. This allows the prepared solution in the mixing container to pass through the first channel 401 and be filtered by the filtration module 40 under the negative pressure of the target container before entering the target container. Furthermore, the ultrasonic degassing module 50 degasses the liquid in the target container to complete the mobile phase preparation process.

[0123] The mobile phase preparation system disclosed in this application can automatically add powder and liquid reagents and mix them. At the same time, the prepared solution can be filtered and loaded into the target container such as the mobile phase bottle through the filtration module 40, and the liquid in the mobile phase bottle can be degassed. This can reduce manual intervention, improve safety, and improve the efficiency and accuracy of mobile phase preparation, thus ensuring product quality.

[0124] It should be noted that the mobile phase preparation system may also include a capping module 80 and a labeling module 90 located at the unloading station 60, as well as a drying module 100 for drying the target container before it contains the preparation liquid. The capping module 80 may consist of a fixing gripper capable of securing the body of the target container and a capping gripper capable of rotating the cap of the target container. The fixing gripper can be driven by the telescopic drive of a telescopic cylinder to press against the body of the target container, thereby securing the target container. Simultaneously, the capping gripper can be positioned above the target container, and can be rotated by a rotary drive such as a rotary motor, thereby removing the cap of the target container, allowing the filtration process to proceed. The labeling module 90 can be composed of a labeling component, a flipping drive such as a flipping cylinder, and a telescopic drive such as a telescopic cylinder. The labeling component can be located on the flipping drive such as the flipping cylinder, and the flipping drive such as the flipping cylinder is installed on the telescopic drive such as the telescopic cylinder. The flipping drive such as the flipping cylinder drives the labeling component to flip downward and pick up the label, and flips it to a position opposite to the target container containing the preparation liquid. The telescopic drive such as the telescopic cylinder drives the labeling component to contact the body of the target container, so that the label can be affixed to the body of the target container.

[0125] The terminology used in the above embodiments is for the purpose of describing specific embodiments only and is not intended to be limiting of this application. As used in the specification and appended claims of this application, the singular expressions "a," "an," "the," "the," "the," and "this" are intended to also include expressions such as "one or more," unless the context clearly indicates otherwise. It should also be understood that in the embodiments of this application, "one or more" refers to one, two, or more; "and / or" describes the relationship between related objects, indicating that three relationships may exist; for example, A and / or B can represent: A alone, A and B simultaneously, or B alone, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship.

[0126] References to "one embodiment" or "some embodiments" as described in this specification mean that one or more embodiments of this application include a specific feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized. The terms "comprising," "including," "having," and variations thereof mean "including but not limited to," unless otherwise specifically emphasized.

[0127] The "multiple" mentioned in the embodiments of this application refers to two or more. It should be noted that in the description of the embodiments of this application, terms such as "first" and "second" are used only for the purpose of distinguishing descriptions and should not be construed as indicating or implying relative importance, nor should they be construed as indicating or implying order.

[0128] The terms "parallel" and "perpendicular" used in this application refer to "basically parallel" and "basically perpendicular" in practical operation. "Basically parallel" can be understood as parallelism with a certain degree of error, and similarly, "basically perpendicular" can be understood as perpendicularity with a certain degree of error.

[0129] The above description of the disclosed embodiments enables those skilled in the art to make or use this application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of this application. Therefore, this application is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A mobile phase preparation system, characterized in that, It includes a feeding module (10) for providing liquid reagents, a powder adding module (20) for providing powder, a liquid adding module (30), a filtration module (40), and an ultrasonic degassing module (50) arranged along the execution direction of the process, wherein: The liquid addition module (30) is used to mix the liquid reagent and the powder and adjust the pH value to obtain the prepared solution in the liquid preparation container; The filtration module (40) is used to filter the prepared liquid in the liquid preparation container into the target container at the unloading station (60). The target container is located below the filtration module (40). The filtration module (40) includes a first channel (401) for communicating with the liquid preparation container and a second channel (402) for communicating with a vacuum source and generating negative pressure in the target container, so that the liquid in the liquid preparation container enters the target container after being filtered by the filtration module (40) through the first channel (401) under the negative pressure of the target container. The ultrasonic degassing module (50) is used to degas the liquid in the target container.

2. The mobile phase preparation system according to claim 1, characterized in that, A filter membrane (403) is provided below the first channel (401) of the filtration module (40). The filtration module (40) also includes a third channel (404) and a flow-driving device. One end of the flow-driving device is used to communicate with the liquid dispensing container of the liquid addition module (30), and the other end of the flow-driving device is used to communicate with the third channel (404). The flow-driving device is used to drive the liquid in the liquid dispensing container to enter the target container through the third channel (404) after being filtered by the filtration module (40) when the filter membrane (403) is a liquid-permeable but air-permeable membrane.

3. The mobile phase preparation system according to claim 2, characterized in that, The filtration module (40) includes a filtration body (405). The lower end of the filtration body (405) is provided with a filtration interface (406) for docking and communicating with a target container. The first channel (401), the second channel (402) and the third channel (404) are all provided on the upper surface of the filtration body (405), and the first channel (401) and the third channel (404) extend into the interior of the filtration body (405) and communicate with the filtration interface (406).

4. The mobile phase preparation system according to claim 3, characterized in that, The filtration body (405) includes a base (407), a first connecting part (408), and a second connecting part (409). The first channel (401) and the third channel (404) are both disposed on the first connecting part (408), and the second channel (402) is disposed on the base (407). The second connecting part (409) is sleeved on the outside of the first connecting part (408) and is connected to the base (407) so that the second connecting part (409) presses the first connecting part (408) onto the base (407).

5. The mobile phase preparation system according to claim 4, characterized in that, The filtration body (405) has a filtration chamber (410) for containing the liquid to be filtered, the filtration membrane (403) is located in the filtration chamber (410), the first connecting part (408) has a first cavity (4081), the base part (407) has a second cavity (4071), the first connecting part (408) is embedded in the second cavity (4071), and the filtration chamber (410) includes at least the first cavity (4081) and the second cavity (4071).

6. The mobile phase preparation system according to claim 5, characterized in that, The outer wall of the first connecting part (408) extends toward the direction away from the central axis of the first connecting part (408) to form a protrusion (4082), the protrusion (4082) is used to press the filter membrane (403) in the filter cavity (410), the side wall of the second cavity (4071) is provided with a step part (4071a), and the protrusion (4082) is provided with a step surface (4082a) that cooperates with the step part (4071a).

7. The mobile phase preparation system according to claim 6, characterized in that, The outer wall of the protrusion (4082) is provided with a protrusion (4082b), and the side wall of the second cavity (4071) is provided with a limiting groove (4071b) for cooperating with the protrusion (4082b). The limiting groove (4071b) is provided with an opening (4071c) to facilitate the sliding of the protrusion (4082b).

8. The mobile phase preparation system according to claim 3, characterized in that, The filtration module (40) includes a filtration assembly and a negative pressure generating assembly. The filtration assembly includes a suction needle (414) for insertion into the first channel (401) and a drainage needle (412) for insertion into the third channel (404). The negative pressure generating assembly includes a negative pressure needle (413) for insertion into the second channel (402). The suction needle (414) is used to communicate with the liquid preparation container through a suction pipe (4142). The drainage needle (412) is used to communicate with the liquid preparation container through a drainage pipe (4124). The negative pressure needle (413) is used to connect with the vacuum source through a gas source pipe.

9. The mobile phase preparation system according to claim 8, characterized in that, The filtration module (40) further includes a driving component (415) and a first elastic component (416). The driving component (415) is used to drive the drainage needle (412), the negative pressure needle (413) and the liquid extraction needle (414) to move toward or away from the target container. The first elastic component (416) is respectively provided with respect to the drainage needle (412), the negative pressure needle (413) and the liquid extraction needle (414). The first elastic component (416) is used to provide a clamping force between at least one of the drainage needle (412), the negative pressure needle (413) and the liquid extraction needle (414) and the filtration body (405).

10. The mobile phase preparation system according to claim 9, characterized in that, The drive assembly (415) includes a mounting plate (4151), a slide rail (4152), and a slide base (4153). There are two slide rails (4152), and the two slide rails (4152) are arranged in parallel on the mounting plate (4151). The slide base (4153) is arranged corresponding to the slide rail (4152). The negative pressure needle (413) and the liquid aspiration needle (414) are respectively connected to the two slide bases (4153). A fixing seat (4151a) is provided on the mounting plate (4151). The first elastic component (416) of the negative pressure needle (413) and the liquid aspiration needle (414) is compressed between the corresponding slide base (4153) and the fixing seat (4151a).

11. The mobile phase preparation system according to claim 10, characterized in that, The mounting plate (4151) is also provided with a connector (418), and the connector (418) can drive the filtration body (405) to move along the mounting plate (4151) toward the direction of approaching or moving away from the target container. The connector (418) is provided with a second elastic component (417), which is used to enable the drainage needle (412), the negative pressure needle (413) and the liquid extraction needle (414) to detach from the filtration body (405) when they move toward the direction of moving away from the target container.

12. The mobile phase preparation system according to claim 1, characterized in that, The liquid addition module (30) includes a first turntable (301), and the unloading station (60) is provided with a second turntable (601). The first turntable (301) includes a plurality of first transfer stations (302) for placing the liquid dispensing container, and at least one of the first transfer stations (302) is a first docking station (303) that docks with the second turntable (601). The second turntable (601) includes a plurality of second transfer stations (602) for placing the target container, and at least one of the second transfer stations (602) is a second docking station (603) that docks with the first turntable (301). The filtration module (40) is located between the first docking station (303) and the second docking station (603). The filtration module (40) is used to filter the liquid in the liquid preparation container located at the first docking station (303) into the target container at the second docking station (603).

13. The mobile phase preparation system according to claim 12, characterized in that, The liquid addition module (30) also includes a pH adjustment component, which is located above the first turntable (301). The pH adjustment component is used to add the liquid reagent toward the liquid preparation container and detect the pH value of the liquid in the liquid preparation container.

14. The mobile phase preparation system according to claim 13, characterized in that, The pH adjustment component includes a liquid addition component (308), a pH detection element (310), and a stirrer (309). The liquid addition component (308) is used to add the liquid reagent into the solution container. The pH detection element (310) is used to detect the pH value of the solution in the solution container and adjust the pH value of the solution in the solution container through the liquid addition component (308). The stirrer (309) is used to stir the solution in the solution container.

15. The mobile phase preparation system according to claim 14, characterized in that, The liquid addition module (30) further includes a liquid addition cleaning component (311), which is located at the center of the first turntable (301). The liquid addition cleaning component (311) is used to clean at least one of the stirrer (309), the pH detection element (310), and the liquid addition component (308).

16. The mobile phase preparation system according to claim 15, characterized in that, The liquid addition cleaning assembly (311) includes a first cleaning tank (312), a second cleaning tank (313), and a drying tank (315). The first cleaning tank (312) includes a waste liquid chamber and a rinsing chamber located in the waste liquid chamber. The rinsing chamber is used to clean the pH detection element (310), and the waste liquid chamber is used to contain the waste liquid after the rinsing chamber cleans the pH detection element (310). The second cleaning tank (313) is provided with a partition plate (314). The second cleaning tank (313) is divided into two cleaning chambers by the partition plate (314). The two cleaning chambers are used to clean the agitator (309) and the liquid addition assembly (308), respectively. The drying tank (315) is used to dry the agitator (309).

17. The mobile phase preparation system according to claim 16, characterized in that, The liquid addition cleaning assembly (311) includes a platform (318) protruding upward from the first turntable (301). The first cleaning tank (312), the second cleaning tank (313), and the drying tank (315) are all located on one side of the platform (318). A pH calibration assembly (319) is provided on the other side of the platform (318). The pH calibration assembly (319) is used to calibrate the pH detection element (310).

18. The mobile phase preparation system according to claim 17, characterized in that, The pH calibration component (319) includes a temperature control zone (320) and a plurality of calibration containers (321) located in the temperature control zone (320), the calibration containers (321) being used to hold standard solutions for calibrating the pH detection element (310).

19. The mobile phase preparation system according to claim 8, characterized in that, It also includes a filtration and cleaning module (70), which is used to clean the filtration assembly. The filtration and cleaning module (70) includes a cleaning liquid container (701), a waste liquid discharge container (702), and a suction module (703). The filtration assembly and the negative pressure generating assembly can be inserted into the suction module (703). The filtration assembly can be connected to the cleaning liquid container (701), and the suction module (703) is connected to the waste liquid discharge container (702). During the cleaning operation, due to the negative pressure effect of the negative pressure generating assembly on the waste liquid discharge container (702), the cleaning liquid in the cleaning liquid container (701) is sucked into the waste liquid discharge container (702) through the filtration assembly.

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