Composition for weight management and preparation method and application thereof

Abstract

The invention provides a composition for body weight management as well as a preparation method and application thereof. The composition for body weight management is prepared from the following raw materials: raspberry, sophora flower bud, cinnamon, poria cocos, oat and grapefruit. According to the present invention, according to the traditional Chinese medicine diet therapy concept, the raspberry, the sophora flower bud, the cinnamon, the poria cocos, the oat, the grapefruit and other medicinal and edible components are selected, and the components beneficial to weight management are matched based on the modern scientific research, such that the compatibility principle of monarch, minister, assistant and guide is provided, and the clear targeting effect mechanism is provided; six components in the composition have a synergistic effect, and the obvious effects of weight management, weight losing and fat reducing can be achieved.

Description

Technical Field

[0001] This invention belongs to the field of food technology, specifically relating to a composition for weight management, its preparation method, and its application. Background Technology

[0002] Traditional Chinese medicine advocates the concept of "food and medicine sharing the same origin," emphasizing the regulation of bodily functions through the natural properties of food to achieve healthy weight loss. The core of this method is not "dieting," but rather using the "medicinal properties" of ingredients to regulate obesity-related constitutions (such as phlegm-dampness, qi deficiency, and damp-heat), improve metabolism, reduce fat accumulation, and protect spleen and stomach function to prevent rebound weight gain.

[0003] CN119857130A discloses a traditional Chinese medicine composition with weight-loss effects and its application. The formula and weight parts of the traditional Chinese medicine composition are as follows: 5-10 parts roselle, 5-10 parts lotus leaf, 2-6 parts cassia seed, 2-6 parts radish seed, 2-6 parts coix seed, 2-6 parts poria cocos, 1-2 parts blood orange, 1-3 parts codonopsis pilosula, 1-2 parts astragalus membranaceus, 1-2 parts euryale ferox, 1-3 parts dendrobium officinale, 1-3 parts ophiopogon japonicus, 1-3 parts cornus officinalis, and 1-3 parts cistanche deserticola. This traditional Chinese medicine composition has a unique and reasonable formulation, a simple preparation method, no toxic side effects, significant effects, low recurrence rate, and low adverse reactions.

[0004] CN119033886A discloses a traditional Chinese medicine formula for weight loss and its application, comprising the following components by weight: 20-25 parts roasted barley, 10-22 parts hemp seeds, 9-20 parts bitter orange blossom, 14-20 parts lotus leaf, 16-20 parts papaya, and 10-16 parts hawthorn. This invention follows the diagnostic theory of traditional Chinese medicine and combines it with modern pharmacological research. The roasted barley, hemp seeds, bitter orange blossom, lotus leaf, papaya, and hawthorn all have certain weight-loss effects and can target most types of obesity. This invention combines the components in a specific ratio, achieving weight loss while maintaining a mild medicinal effect without excessive stimulation to the body. Furthermore, all components are natural materials that are both food and medicine, making them safe, inexpensive, and readily available.

[0005] However, while existing weight-loss substitutes also use many plant-based ingredients, their effects are often limited due to improper formulation, preventing the active ingredients from being fully utilized. Alternatively, the bitterness and unpleasant taste of the herbs can make it difficult for consumers to maintain consistent use, thus failing to achieve the desired results. Therefore, developing a product that is both effective and has an appealing taste is essential. Summary of the Invention

[0006] To address the shortcomings of existing technologies, this invention provides a composition for weight management, its preparation method, and its application. To achieve this objective, the invention employs the following technical solution:

[0007] In a first aspect, the present invention provides a composition for weight management, wherein the raw materials for preparing the composition for weight management include raspberry, sophora japonica, cinnamon, poria cocos, oats and grapefruit.

[0008] The raspberries described in this invention contain raspberry ketones, vitamin C, dietary fiber, etc., which can promote the decomposition of fat cells, increase satiety, and reduce total calorie intake; Sophora japonica buds contain rutin (vitamin P), flavonoids, and polyphenols, which can regulate lipid metabolism, reduce serum total cholesterol (TC) and triglyceride (TG) levels, inhibit fat cell differentiation, and reduce lipid absorption; cinnamon contains cinnamaldehyde, cinnamic acid, etc., which can improve insulin sensitivity, inhibit lipase activity, and reduce the efficiency of fat digestion and absorption in the diet; Poria cocos contains poria polysaccharides, triterpenoids, etc., which can regulate the balance of intestinal flora, inhibit fat synthesis, and promote fat decomposition and metabolism; oats contain β-glucan, dietary fiber, phytosterols, etc., which can increase satiety, reduce calorie intake, inhibit cholesterol absorption, and regulate intestinal peristalsis; grapefruit contains naringin, vitamin C, etc., which can promote fat decomposition, inhibit lipase activity, and reduce fat production. The invention creatively discovers that when these six ingredients are used together, they can achieve a weight loss and lipid reduction effect of 1+1>2 by inhibiting fat synthesis, promoting fat metabolism, regulating metabolic efficiency, reducing calorie absorption, and improving the metabolic environment.

[0009] Preferably, the raw materials for preparing the composition for weight management include, by dry weight, 20-30 parts raspberry, 5-25 parts sophora japonica, 5-15 parts cinnamon, 8-18 parts poria cocos, 5-20 parts oats, and 3-18 parts grapefruit.

[0010] The amount of raspberry used in the raw materials for preparing the composition for weight management of the present invention can be 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts or 29 parts, etc.

[0011] The amount of Sophora japonica buds can be 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts, 22 parts or 24 parts, etc.;

[0012] The amount of cinnamon used can be 6, 7, 8, 9, 10, 11, 12, 13 or 14 parts, etc.

[0013] The dosage of Poria cocos can be 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17 parts, etc.

[0014] The amount of oats used can be 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 or 19 parts, etc.

[0015] The amount of grapefruit used can be 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17 parts, etc.

[0016] Preferably, the raw materials for preparing the composition for weight management include, by dry weight, 22-28 parts raspberry, 8-20 parts sophora japonica, 8-13 parts cinnamon, 10-16 parts poria cocos, 8-15 parts oats, and 5-15 parts grapefruit.

[0017] Preferably, the raw materials for preparing the composition for weight management include, by dry weight, 23-26 parts of raspberry, 10-15 parts of sophora japonica, 9-12 parts of cinnamon, 12-15 parts of poria cocos, 10-15 parts of oats, and 10-15 parts of grapefruit.

[0018] Preferably, the raw materials for preparing the composition for weight management further include any one or a combination of at least two of the following: bitter orange blossom, amla, dendrobium officinale, or dried ginger.

[0019] Preferably, the raw materials for preparing the composition for weight management further include bitter orange flower, amla fruit, dendrobium officinale and dried ginger.

[0020] As a preferred technical solution of the present invention, the combination of bitter orange flower, amla fruit, dendrobium officinale and dried ginger can further improve the weight loss and lipid reduction effect of the composition by promoting metabolism and energy conversion, smooth digestion, inhibiting fat production and regulating body condition.

[0021] Preferably, the raw materials for preparing the composition for weight management further include, by dry weight, 5-15 parts of bitter orange flower (e.g., 6, 7, 8, 9, 10, 11, 12, 13, or 14 parts), 3-15 parts of amla fruit (e.g., 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 parts), 5-15 parts of dendrobium officinale (e.g., 6, 7, 8, 9, 10, 11, 12, 13, or 14 parts), and 2-10 parts of dried ginger (e.g., 3, 4, 5, 6, 7, 8, or 9 parts).

[0022] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0023] In a second aspect, the present invention provides a method for preparing a composition for weight management as described in the first aspect, the method comprising pulverizing raspberry, sophora japonica, cinnamon, poria cocos, oats and grapefruit respectively, and then mixing them with water to obtain the composition for weight management.

[0024] Preferably, the preparation method includes:

[0025] (1) Raspberry, Sophora japonica, cinnamon, bitter orange, amla, Dendrobium officinale, Poria cocos, dried ginger, oats and grapefruit are crushed separately and then mixed to obtain a mixture.

[0026] (2) The mixture is soaked after being mixed with water, then boiled and extracted, and filtered to obtain plant extract;

[0027] (3) The plant extract is concentrated to obtain the composition for weight management.

[0028] Preferably, the pulverization to 10-30 mesh in step (1) can be, for example, 12 mesh, 15 mesh, 18 mesh, 20 mesh, 22 mesh, 25 mesh or 28 mesh.

[0029] Preferably, the ratio of the mixture to water in step (2) is 0.05-0.1 g / mL, for example, it can be 0.06 g / mL, 0.07 g / mL, 0.08 g / mL or 0.09 g / mL.

[0030] Preferably, the soaking time in step (2) is 0.5-1.5h, for example, it can be 0.6h, 0.8h, 1h, 1.2h or 1.4h.

[0031] Preferably, the decoction extraction in step (2) is performed 1-3 times, for example, once, twice or three times.

[0032] Preferably, the temperature for each decoction extraction is independently 90-100℃ (e.g., 91℃, 93℃, 95℃, 97℃ or 99℃, etc.), and the time is 1-2h (e.g., 1.1h, 1.3h, 1.5h, 1.7h or 1.9h, etc.).

[0033] Preferably, the filter used in step (2) is a 200-300 mesh filter cloth (e.g., 210 mesh, 230 mesh, 250 mesh, 270 mesh or 290 mesh, etc.).

[0034] Preferably, the concentration in step (3) is a vacuum concentration.

[0035] Preferably, the temperature of the vacuum concentration is 50-60℃ (e.g., 51℃, 53℃, 55℃, 57℃ or 59℃, etc.), and the vacuum degree is -0.02~-0.04 MPa (e.g., -0.02 MPa, -0.03 MPa or -0.04 MPa, etc.).

[0036] Preferably, the concentration is made to a specific gravity of 1.1-1.2, for example, 1.11, 1.13, 1.15, 1.17 or 1.19.

[0037] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0038] Thirdly, the present invention provides the use of the composition for weight management as described in the first aspect in the preparation of food or beverage.

[0039] Fourthly, the present invention provides a plant-based beverage for weight management, wherein the plant-based beverage for weight management comprises, by weight, 5-50 parts of the composition for weight management as described in the first aspect, 2-15 parts of sugar alcohol, 0.01-0.1 parts of sweetener, 0.05-1.5 parts of acidity regulator and 35-95 parts of water.

[0040] The amount of the weight management composition added to the plant-based beverage for weight management of the present invention can be 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, or 45 parts, etc.

[0041] The amount of sugar alcohol added can be 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts, etc.

[0042] The amount of sweetener added can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, or 0.09 parts, etc.;

[0043] The amount of acidity regulator added can be 0.06 parts, 0.08 parts, 0.1 parts, 0.3 parts, 0.5 parts, 0.7 parts, or 0.9 parts, etc.;

[0044] The amount of water added can be 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, or 90 parts, etc.

[0045] Preferably, the sugar alcohol includes any one or a combination of at least two of sorbitol, mannitol, erythritol, maltitol, lactitol, or xylitol.

[0046] Preferably, the sweetener includes any one or a combination of at least two of sucralose, steviol glycosides, honey, or inulin.

[0047] Preferably, the acidity regulator includes any one or a combination of at least two of citric acid, tartaric acid, malic acid, or lactic acid.

[0048] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0049] Fifthly, the present invention provides a method for preparing a plant-based beverage for weight management as described in the fourth aspect, the method comprising:

[0050] (1) Heat water to 50-60℃ (e.g., 51℃, 53℃, 55℃, 57℃ or 59℃, etc.) and predissolve sugar alcohol, sweetener and acidity regulator in water respectively;

[0051] (2) Add the composition for weight management, the pre-dissolved sweetener and the pre-dissolved acidity regulator to the pre-dissolved sugar alcohol, stir evenly, and then add water to make up the volume to obtain a mixture.

[0052] (3) The mixture is passed through a 200-300 mesh (e.g., 210 mesh, 230 mesh, 250 mesh, 270 mesh or 290 mesh, etc.) filter, sterilized, and then bottled to obtain the plant beverage for weight management.

[0053] All the specific point values ​​within the above range can be selected, and will not be elaborated on here.

[0054] Compared with the prior art, the present invention has the following beneficial effects:

[0055] This invention follows the principles of traditional Chinese medicine dietary therapy, selecting ingredients that are both food and medicine, such as raspberry, sophora japonica, cinnamon, poria cocos, oats, and grapefruit. Based on modern scientific research, these ingredients that help with weight management are combined in a way that follows the principles of "principal, assistant, adjuvant, and guide" in traditional Chinese medicine formulation, and has a clear and well-defined targeted mechanism of action. The six ingredients in the composition work synergistically to achieve significant weight management, weight loss, and fat reduction effects. Detailed Implementation

[0056] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments described are merely illustrative of the present invention and should not be construed as limiting the invention in any way.

[0057] The raw materials used in the embodiments or comparative examples of this invention can be used as long as they are purchased from authorized distributors.

[0058] Example 1

[0059] This embodiment provides a composition for weight management. The raw materials for preparing the composition for weight management are, by dry weight, 25 parts raspberry, 15 parts sophora japonica, 10 parts cinnamon, 10 parts bitter orange, 10 parts amla, 10 parts dendrobium officinale, 13 parts poria cocos, 8 parts dried ginger, 13 parts oats, and 13 parts grapefruit.

[0060] The method for preparing the composition for weight management is as follows:

[0061] (1) Raw material pretreatment: Select the raw materials and remove impurities; crush raspberry, sophora japonica, cinnamon, bitter orange, amla, dendrobium officinale, poria cocos, dried ginger, oats and grapefruit into powder, pass through a 20-mesh sieve, and then mix them to obtain a mixture.

[0062] (2) Mix the mixture with water (15 times the amount of the mixture) and soak for 1 hour. Then heat to 95°C and decoct to extract. Extract 3 times, each time for 1.5 hours. Combine the extracts and then filter the extract through a 250-mesh filter cloth to obtain plant extract.

[0063] (3) The plant extract was concentrated to a specific gravity of 1.15 at 55°C and a vacuum of -0.03 MPa to obtain the composition for weight management.

[0064] Example 2

[0065] This embodiment provides a composition for weight management. The raw materials for preparing the composition for weight management are, by dry weight, 28 parts of raspberry, 12 parts of sophora japonica, 13 parts of cinnamon, 8 parts of bitter orange, 13 parts of amla, 8 parts of dendrobium officinale, 16 parts of poria cocos, 5 parts of dried ginger, 15 parts of oats, and 8 parts of grapefruit.

[0066] The method for preparing the composition for weight management is as follows:

[0067] (1) Raw material pretreatment: Select the raw materials and remove impurities; crush raspberry, sophora japonica, cinnamon, bitter orange, amla, dendrobium officinale, poria cocos, dried ginger, oats and grapefruit into powder, pass through a 10-mesh sieve, and then mix them to obtain a mixture.

[0068] (2) Mix the mixture with water (20 times the amount of the mixture) and soak for 0.5 h. Then heat to 100°C and decoct to extract. Extract twice, each time for 1 h. Combine the extracts and then filter the extract through a 300-mesh filter cloth to obtain plant extract.

[0069] (3) The plant extract was concentrated to a specific gravity of 1.1 at 50°C and a vacuum of -0.04 MPa to obtain the composition for weight management.

[0070] Example 3

[0071] This embodiment provides a composition for weight management. The raw materials for preparing the composition for weight management are, by dry weight, 20 parts of raspberry, 25 parts of sophora japonica, 5 parts of cinnamon, 15 parts of bitter orange, 5 parts of amla, 15 parts of dendrobium officinale, 8 parts of poria cocos, 10 parts of dried ginger, 10 parts of oats, and 8 parts of grapefruit.

[0072] The method for preparing the composition for weight management is as follows:

[0073] (1) Raw material pretreatment: Select the raw materials and remove impurities; crush raspberry, sophora japonica, cinnamon, bitter orange, amla, dendrobium officinale, poria cocos, dried ginger, oats and grapefruit into powder, pass through a 30-mesh sieve, and then mix them to obtain a mixture.

[0074] (2) Mix the mixture with water (10 times the amount of the mixture) and soak for 1.5 hours. Then heat to 90°C and decoct to extract. Extract once for 2 hours. Combine the extracts and then filter the extract through a 200-300 mesh filter cloth to obtain plant extract.

[0075] (3) The plant extract was concentrated to a specific gravity of 1.2 at 60°C and a vacuum of -0.02 MPa to obtain the composition for weight management.

[0076] Example 4

[0077] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials used in the preparation do not include bitter orange blossom, amla, dendrobium officinale and dried ginger. The remaining components and dosages are the same as in Example 1, and the preparation method is the same as in Example 1.

[0078] Example 5

[0079] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials do not include bitter orange blossom. The amount of bitter orange blossom is reduced and allocated to Phyllanthus emblica, Dendrobium officinale and dried ginger in proportion. The remaining components and dosages are the same as in Example 1. The preparation method is the same as in Example 1.

[0080] Example 6

[0081] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials do not include Phyllanthus emblica. The reduced amount is allocated to Citrus aurantium, Dendrobium officinale and dried ginger in proportion. The remaining components and dosages are the same as in Example 1. The preparation method is the same as in Example 1.

[0082] Example 7

[0083] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials do not include Dendrobium officinale. The amount of Dendrobium officinale is reduced and allocated to Citrus aurantium, Phyllanthus emblica and dried ginger in proportion. The remaining components and dosages are the same as in Example 1. The preparation method is the same as in Example 1.

[0084] Example 8

[0085] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials do not include dried ginger. The amount of dried ginger is reduced and allocated to Citrus aurantium, Phyllanthus emblica and Dendrobium officinale in proportion. The remaining components and dosages are the same as in Example 1. The preparation method is the same as in Example 1.

[0086] Example 9

[0087] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials used in the preparation are 10 parts oats and 16 parts grapefruit. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0088] Example 10

[0089] This embodiment provides a composition for weight management. The only difference between the composition for weight management and that of Example 1 is that the raw materials used in the preparation are 20 parts oats and 6 parts grapefruit. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0090] Comparative Example 1

[0091] This comparative example provides a composition for weight management. The composition for weight management differs from that of Example 1 only in that the raw materials do not include raspberries. The reduced amount is made up by the proportions of Sophora japonica, cinnamon, Poria cocos, oats, and grapefruit. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0092] Comparative Example 2

[0093] This comparative example provides a composition for weight management. The only difference between the composition for weight management and Example 1 is that the raw materials do not include Sophora japonica flowers. The reduction is made up by raspberry, cinnamon, Poria cocos, oats and grapefruit in proportion. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0094] Comparative Example 3

[0095] This comparative example provides a composition for weight management. The only difference between the composition for weight management and Example 1 is that the raw materials do not include cinnamon. The reduction is made up by raspberry, sophora japonica, poria cocos, oats and grapefruit in proportion. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0096] Comparative Example 4

[0097] This comparative example provides a composition for weight management. The composition for weight management differs from that of Example 1 only in that the raw materials do not include Poria cocos. The reduced amount is made up by raspberry, Sophora japonica, cinnamon, oats and grapefruit in proportion. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0098] Comparative Example 5

[0099] This comparative example provides a composition for weight management. The only difference between the composition for weight management and Example 1 is that oats are not included in the raw materials. The reduction is made up by raspberry, sophora japonica, cinnamon, poria cocos and grapefruit in proportion. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0100] Comparative Example 6

[0101] This comparative example provides a composition for weight management. The composition for weight management differs from that of Example 1 only in that the raw materials do not include grapefruit. The reduction is made up by raspberry, sophora japonica, cinnamon, poria cocos and oats in proportion. The remaining components and amounts are the same as in Example 1, and the preparation method is the same as in Example 1.

[0102] Application Example 1

[0103] This application example provides a plant-based beverage for weight management. The components of the plant-based beverage, by weight, are 30 parts of the weight management composition of Example 1, 10 parts of sugar alcohol, 0.05 parts of sucralose, 0.08 parts of malic acid, and the remainder is made up to 100 parts by water.

[0104] The sugar alcohols are sorbitol, mannitol, and erythritol in a mass ratio of 1:1:1.

[0105] The preparation method of the plant-based beverage for weight management is as follows:

[0106] (1) Heat water to 55°C and predissolve sugar alcohol, sweetener and acidity regulator in water respectively;

[0107] (2) Add the composition for weight management, the pre-dissolved sweetener and the pre-dissolved acidity regulator to the pre-dissolved sugar alcohol, stir evenly, and then add water to make up the volume to obtain a mixture.

[0108] (3) The mixture is passed through a 300-mesh filter, sterilized by UHT, and then bottled to obtain the plant-based beverage for weight management.

[0109] Application Example 2-10

[0110] The application examples provide nine plant-based beverages for weight management. The only difference between these plant-based beverages and Application Example 1 is that the weight management composition of Example 1 is replaced in equal amounts with the weight management compositions of Examples 2-10. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0111] Comparative Application Examples 1-6

[0112] The comparative application examples provide six plant-based beverages for weight management. The only difference between these plant-based beverages and Application Example 1 is that the weight management composition of Example 1 is replaced in equal amounts with the weight management compositions of Comparative Examples 1-6. The remaining components and amounts are the same as in Application Example 1, and the preparation method is the same as in Application Example 1.

[0113] Test Example 1: Acute Toxicity Test

[0114] (1) Experimental Procedure: 170 mice weighing 18-22 g were selected, half male and half female, and divided into 17 groups (blank control group, application cases 1-10, and comparative cases 1-6), with 10 mice in each group. The use of experimental animals was carried out in accordance with the regulations for the use of experimental animals. Animals were kept under a 12h / 12h light-dark cycle, with a temperature of 23±1℃ and a humidity of 50±10%, and free access to food and water. All test mice were fasted overnight for 4-6 hours before the experiment, but water was not restricted. In the formal experiment, the gavage dose was 600 ml / (kg·d) (approximately equivalent to 15 times the daily dose for adults), and concentrated to a certain proportion before being administered to the test. Based on the maximum gavage concentration, gavage volume, and safety factor of the sample, the test substance dose was set at 20.0 mL / kg BW, i.e., the gavage volume was 0.4 mL / mouse per administration. The test sample (samples of application examples 1-10 and control examples 1-6) was administered twice over 24 hours. The blank control group was given purified water. After the administration was completed, the mice were observed for 14 consecutive days, and the toxic symptoms and mortality were recorded.

[0115] (2) Experimental results: No deaths or abnormalities occurred in mice under normal feeding conditions within 14 days after administration. The experiment proved that the plant beverage of the present invention has an acute oral LD50 in mice. 50 >600mL / (kg·d) indicates that this plant-based beverage has no toxic side effects and is safe to use.

[0116] Test Example 2: Animal Efficacy Test

[0117] Test method:

[0118] (1) 180 mice weighing 18-22 g were selected and fed acclimatized for 7 days before the experiment began. The mice were randomly divided into 18 groups: blank group, model group, application examples 1-10 groups, and control application examples 1-6 groups, with 10 mice in each group. The blank group was fed a normal diet, while the model group, application examples group, and control application examples group were fed a high-fat diet for 30 consecutive days to establish a nutritional obesity model. After successful modeling, the blank group continued to be fed a normal diet, while the model group, application examples group, and control examples group continued to be fed a high-fat diet. At the same time, the application examples group and control application examples group were given samples corresponding to application examples 1-10 and control examples 1-6 by gavage every day at a volume of 20 mL / kg. The blank group and model group were given an equal volume of physiological saline by gavage. The test samples or physiological saline were administered twice a day, with an interval of 6 hours. The administration was carried out by gavage for 8 weeks. The condition of the mice was observed, weighed, and recorded at weeks 0, 4, and 8.

[0119] (2) Eight weeks after administration, all mice were fasted for 12 hours and then whole blood was collected. The supernatant was centrifuged and serum was obtained. The levels of total cholesterol (TC), triglycerides (TG) and leptin in the serum were detected using a kit.

[0120] The results are shown in Table 1.

[0121] Table 1

[0122]

[0123] As shown in Table 1, compared with the model group, the mice that consumed the products of Application Examples 1-3 of this invention had significantly lower body weight, serum total cholesterol, triglycerides, and serum leptin levels, indicating that the composition of this invention can stably reduce the body weight of mice.

[0124] As can be seen from application examples 4-8, adding bitter orange blossom, amla, dendrobium officinale and dried ginger to the composition can achieve better weight management, and bitter orange blossom, amla, dendrobium officinale and dried ginger have a synergistic effect in weight loss.

[0125] As can be seen from Application Examples 9-10, the mass ratio of oats to grapefruit also affects the effect of the composition on weight loss and weight management.

[0126] As can be seen from the comparative application examples 1-6, the combination of six ingredients—raspberry, sophora japonica, cinnamon, poria cocos, oats, and grapefruit—is necessary to enhance the weight loss effect of the composition. All six are indispensable, and the absence of any one of them will reduce the efficacy of the product.

[0127] Test Example 3: Human Trial Verification

[0128] (1) Subject selection criteria: ① Females aged 30-50 years; ② BMI ≥ 24 kg / m 2(Overweight / Obesity); ③ Women with a waist circumference ≥85cm; ④ No weight loss drugs or traditional Chinese medicine treatment in the past 6 months; ⑤ Exclusion criteria: Pregnant women and women preparing for pregnancy, breastfeeding women, those allergic to the components of the composition of this invention, and those in a disease state shall not participate in this test;

[0129] (2) 136 eligible participants were recruited. The participants were randomly divided into 17 groups (placebo group, application cases 1-10 group, and control application cases 1-6 group), with 8 participants in each group. The placebo group participants consumed a placebo (plain apple juice) daily; the application cases 1-10 group and the control application cases 1-6 group consumed the samples from application cases 1-10 and control application cases 1-6, respectively, twice daily, after lunch and dinner, for a period of 8 weeks. All participants maintained their original diet and exercise habits. Weight, BMI, waist circumference, and body fat percentage were monitored and recorded before the start of the trial (week 0), at week 4, and at week 8.

[0130] The results are shown in Table 2-5.

[0131] Table 2

[0132]

[0133] Table 3

[0134]

[0135] Table 4

[0136]

[0137] Table 5

[0138]

[0139] As shown in Tables 2-5, compared with the placebo group, volunteers who consumed the products of Application Examples 1-3 of this invention also experienced significant reductions in weight, BMI, body fat percentage, and waist circumference, indicating that the composition of this invention can achieve significant weight loss and weight control effects.

[0140] As can be seen from application examples 4-8, adding bitter orange blossom, amla, dendrobium officinale and dried ginger to the composition can achieve better weight management, and bitter orange blossom, amla, dendrobium officinale and dried ginger have a synergistic effect in weight loss.

[0141] As can be seen from Application Examples 9-10, the mass ratio of oats to grapefruit also affects the effect of the composition on weight loss and weight management.

[0142] As can be seen from the comparative application examples 1-6, the combination of six ingredients—raspberry, sophora japonica, cinnamon, poria cocos, oats, and grapefruit—is necessary to enhance the weight loss effect of the composition. All six are indispensable, and the absence of any one of them will reduce the efficacy of the product.

[0143] The applicant declares that the present invention illustrates a composition for weight management, its preparation method, and its application through the above embodiments. However, the present invention is not limited to the above embodiments, i.e., it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of the raw materials of the product, addition of auxiliary components, and selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0144] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0145] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A composition for weight management, characterized in that, The raw materials for preparing the composition for weight management include raspberry, sophora japonica buds, cinnamon, poria cocos, oats, and grapefruit.

2. The composition for weight management as described in claim 1, characterized in that, The raw materials for preparing the composition for weight management include, by dry weight, 20-30 parts of raspberry, 5-25 parts of sophora japonica, 5-15 parts of cinnamon, 8-18 parts of poria cocos, 5-20 parts of oats, and 3-18 parts of grapefruit. Preferably, the raw materials for preparing the composition for weight management include, by dry weight, 22-28 parts of raspberry, 8-20 parts of sophora japonica, 8-13 parts of cinnamon, 10-16 parts of poria cocos, 8-15 parts of oats, and 5-15 parts of grapefruit. Preferably, the raw materials for preparing the composition for weight management include, by dry weight, 23-26 parts of raspberry, 10-15 parts of sophora japonica, 9-12 parts of cinnamon, 12-15 parts of poria cocos, 10-15 parts of oats and 10-15 parts of grapefruit. Preferably, the mass ratio of oats to grapefruit is 1:(0.5-1).

3. The composition for weight management as described in claim 1 or 2, characterized in that, The raw materials for preparing the composition for weight management also include any one or a combination of at least two of the following: bitter orange flower, amla fruit, dendrobium officinale, or dried ginger; Preferably, the raw materials for preparing the composition for weight management further include bitter orange flower, amla fruit, dendrobium officinale and dried ginger.

4. The composition for weight management as described in any one of claims 1-3, characterized in that, The raw materials for preparing the composition for weight management also include, by dry weight, 5-15 parts of bitter orange flower, 3-15 parts of amla fruit, 5-15 parts of dendrobium officinale, and 2-10 parts of dried ginger.

5. A method for preparing a composition for weight management as described in any one of claims 1-4, characterized in that, The preparation method includes pulverizing raspberry, sophora japonica buds, cinnamon, poria cocos, oats and grapefruit separately, and then mixing them with water to obtain the composition for weight management.

6. The preparation method according to claim 5, characterized in that, The preparation method includes: (1) Raspberry, Sophora japonica, cinnamon, bitter orange, amla, Dendrobium officinale, Poria cocos, dried ginger, oats and grapefruit are crushed separately and then mixed to obtain a mixture. (2) The mixture is soaked after being mixed with water, then boiled and extracted, and filtered to obtain plant extract; (3) The plant extract is concentrated to obtain the composition for weight management.

7. The preparation method according to claim 6, characterized in that, The step (1) involves pulverizing the material to 10-30 mesh. Preferably, the material-to-liquid ratio of the mixture to water in step (2) is 0.05-0.1 g / mL; Preferably, the soaking time in step (2) is 0.5-1.5 hours; Preferably, the decoction extraction in step (2) is performed 1-3 times; Preferably, the temperature for each decoction extraction is independently set at 90-100℃, and the time is 1-2 hours. Preferably, the filter used in step (2) is a 200-300 mesh filter cloth; Preferably, the concentration in step (3) is vacuum concentration; Preferably, the temperature for vacuum concentration is 50-60℃, and the vacuum degree is -0.02~-0.04 MPa; Preferably, the concentration is made to a specific gravity of 1.1-1.

2.

8. The use of a composition for weight management as described in any one of claims 1-4 in the preparation of food or beverage.

9. A plant-based beverage for weight management, characterized in that, The plant-based beverage for weight management comprises, by weight, 5-50 parts of the composition for weight management as described in any one of claims 1-4, 2-15 parts of sugar alcohol, 0.01-0.1 parts of sweetener, 0.05-1.5 parts of acidity regulator, and 35-95 parts of water.

10. The plant-based beverage for weight management as described in claim 9, characterized in that, The sugar alcohols include any one or a combination of at least two of the following: sorbitol, mannitol, erythritol, maltitol, lactitol, or xylitol; Preferably, the sweetener comprises any one or a combination of at least two of sucralose, steviol glycosides, honey, or inulin; Preferably, the acidity regulator includes any one or a combination of at least two of citric acid, tartaric acid, malic acid, or lactic acid.

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