Eye protection patch for promoting blood circulation and relieving muscular soreness and preparation method thereof

Abstract

The invention provides an eye protection patch for promoting blood circulation and relieving muscular soreness and a preparation method of the eye protection patch, and relates to the technical field of eye protection nursing. The eye protection patch comprises a base material layer, a drug sustained-release layer and a protective film layer, the drug sustained-release layer is loaded with a composite active component, and the composite active component is formed by compounding a traditional Chinese medicine extracting solution, a penetration enhancer, an antioxidant and a humectant according to a specific proportion; the traditional Chinese medicine extracting solution is prepared from multiple traditional Chinese medicines such as angelica sinensis, salvia miltiorrhiza, mint and chamomile through a gradient extraction process, and the traditional Chinese medicines can synergistically play roles in dilating blood vessels, promoting eye blood circulation and inhibiting release of inflammatory factors; the penetration enhancer accelerates the transdermal absorption of the active components by improving the permeability of the skin cuticle; and the antioxidant and the humectant can maintain the stability of the active ingredients and prolong the duration of the drug effect. According to the eye protection patch, through the synergistic effect of multiple components, eye muscle soreness, dryness and fatigue can be rapidly relieved, eye blood circulation disorder is improved, and the eye protection patch is suitable for daily eye protection nursing of people using eyes for a long time.

Description

Technical Field

[0001] This invention relates to the field of eye care technology, specifically to an eye patch that promotes blood circulation and relieves muscle soreness, and its preparation method. Background Technology

[0002] With the continuous improvement of information technology in modern society, it has become the norm for people to use electronic devices (such as mobile phones, computers, tablets, etc.) for a long time during their daily work, study and entertainment. In addition, due to poor eye habits, unsuitable ambient light and other factors, the eye muscles are in a state of tension and contraction for a long time, which can easily lead to poor blood circulation in the eyes, muscle soreness, dryness and fatigue. In severe cases, it may also cause eye diseases such as decreased vision, conjunctivitis, and dry eye syndrome.

[0003] Currently, there are many types of eye patches on the market, but most of their functions focus on basic care such as moisturizing and cooling, with limited specificity in promoting blood circulation around the eyes and relieving muscle soreness. The active ingredients in existing eye patches are mostly single plant extracts or chemical moisturizers, lacking a multi-component synergistic mechanism. Furthermore, the transdermal absorption efficiency of active ingredients is low, and the duration of effect is short, making it difficult to fundamentally improve eye blood circulation disorders and muscle soreness. In addition, some eye patches contain irritating ingredients, and long-term use may cause adverse reactions such as allergies and redness around the eyes, raising concerns about their safety.

[0004] Therefore, developing an eye patch product with good ingredient synergy, high transdermal absorption efficiency, effective promotion of blood circulation in the eyes, relief of muscle soreness, and high safety has become an urgent need in the current eye care field. Summary of the Invention

[0005] This invention provides an eye patch that promotes blood circulation and relieves muscle soreness, as well as its preparation method. It can effectively solve the problems of existing eye patches, such as poor targeting, ineffective efficacy, and insufficient safety, and achieve precise eye care.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solution: In a first aspect, the present invention provides an eye patch that promotes blood circulation and relieves muscle soreness, comprising a protective film layer, a drug sustained-release layer, and a substrate layer sequentially layered from top to bottom; the drug sustained-release layer is loaded with a composite active ingredient, the composite active ingredient comprising 40-60 parts of traditional Chinese medicine extract, 5-12 parts of penetration enhancer, 2-5 parts of antioxidant, 8-15 parts of moisturizer, and 10-20 parts of deionized water; the traditional Chinese medicine extract is prepared by a gradient extraction process from Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong in a weight ratio of (3-5):(2-4):(1-3):(2-5):(3-6):(2-4):(1-2); the penetration enhancer is a compound system of menthol and laurocapram; the antioxidant is a compound system of vitamin E and glutathione; and the moisturizer is a compound system of sodium hyaluronate and glycerin.

[0007] As a further improvement to the technical solution of the present invention, the weight ratio of menthol to laurocapram is (1-3):(1-2), the weight ratio of vitamin E to glutathione is (2-4):(1-3), and the weight ratio of sodium hyaluronate to glycerin is (1-2):(3-5).

[0008] As a further improvement to the technical solution of the present invention, the substrate layer is a medical non-woven fabric or hydrogel substrate, the thickness of the substrate layer is 0.1-0.3 mm, and the surface of the substrate layer is provided with a plurality of pores with a diameter of 50-200 μm. The ventilation holes have an opening ratio of 15-30%. .

[0009] As a further improvement to the technical solution of the present invention, the thickness of the drug sustained-release layer is 0.2-0.5 mm, and the loading of the composite active ingredient in the drug sustained-release layer is... Furthermore, the in vitro release curve of the drug sustained-release layer satisfies the following condition: the cumulative release rate within 2 hours is [missing information]. The cumulative release rate within 4 hours is Cumulative release rate within 8 hours .

[0010] As a further improvement to the technical solution of the present invention, the protective film layer is a polyethylene terephthalate film or a polyethylene film, the thickness of the protective film layer is 0.05-0.1mm, and the side of the protective film layer away from the drug sustained-release layer is provided with anti-slip texture.

[0011] A second aspect of this invention provides a method for preparing an eye patch that promotes blood circulation and relieves muscle soreness, comprising the following steps: S1. Preparation of Chinese herbal extract: Weigh out Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong according to the weight ratio, pulverize them and pass them through a 40-60 mesh sieve to obtain Chinese herbal powder; mix the Chinese herbal powder with the extraction solvent at a material-to-liquid ratio of 1:(10-20). Mix, then pass through 80-90 degrees Celsius in sequence. Hot water extraction for 1-2 hours, 60-70 Ultrasonic extraction for 30-60 min, combined extracts, filtered, and concentrated under reduced pressure to a relative density of 1.10-1.20 (25℃) to obtain the herbal extract; S2. Blending of Compound Active Ingredients: Add the penetration enhancer, antioxidant, and humectant to deionized water and stir until completely dissolved to obtain a mixed excipient solution; slowly add the herbal extract to the mixed excipient solution, and stir for 30-40 minutes. Stir at 200-300 r / min for 30-60 min, then homogenize 2-3 times with a high-pressure homogenizer at 20-30 MPa pressure to obtain the composite active ingredients; S3. Substrate pretreatment: The substrate layer is sterilized under ultraviolet light for 15-20 minutes, and then its surface is modified by plasma treatment instrument with a treatment power of 50-80W and a treatment time of 5-10 minutes. S4. Drug Loading: The composite active ingredient prepared in step S2 is uniformly coated onto the surface of the pretreated substrate layer, with a coating amount of [missing information]. Then at 40-50 Relative humidity 30-40 Dry in an environment for 10-20 minutes to form a drug sustained-release layer;

[0012] S5. Composite molding: The protective film layer is laminated onto the side of the drug sustained-release layer away from the substrate layer, and after cutting and packaging, an eye patch that promotes blood circulation and relieves muscle soreness is obtained.

[0013] As a further improvement to the technical solution of the present invention, the extraction solvent in step S1 has a volume fraction of 40-60%. The ethanol-water solution was concentrated under reduced pressure at a vacuum of 0.06-0.09 MPa and a concentration temperature of 50-60°C. .

[0014] As a further improvement to the technical solution of the present invention, the temperature of the high-pressure homogenization in step S2 is controlled at 25-35°C. During the homogenization process, citric acid or sodium hydroxide is used to adjust the pH of the system to 5.5-6.5.

[0015] As a further improvement to the technical solution of the present invention, in step S4, the coating method adopts slot coating or anilox roller coating, and the drying process adopts hot air circulation drying with an air velocity of .

[0016] The third aspect of the present invention provides the application of the above-mentioned eye patch, which can be used to prepare care products for improving blood circulation in the eyes and relieving eye muscle fatigue and soreness. It is suitable for daily use by people who use their eyes for long periods of time (such as office workers, students, drivers, etc.) and can also be used as an auxiliary care during the recovery period after eye surgery.

[0017] The technical solution of the present invention has the following advantages over the prior art: This invention's eye patch achieves synergistic effects through a scientifically designed layered composite structure and precisely proportioned compound active ingredients. Its core advantage lies in its use of extracts from a blend of multiple traditional Chinese medicines. Angelica sinensis and Salvia miltiorrhiza synergistically dilate capillaries in the eye and reduce blood viscosity; peppermint and chamomile effectively inhibit the release of inflammatory factors; Lycium barbarum and Cassia tora protect retinal nerve cells; and Ligusticum chuanxiong enhances the transport efficiency of active ingredients. This multi-effect combination achieves precise targeting of blood circulation promotion and muscle soreness relief. Furthermore, the patch is combined with a penetration enhancer (menthol and lauryl azedarach), an antioxidant (vitamin E and glutathione), and a moisturizer (sodium hyaluronate and glycerin), significantly improving the transdermal absorption efficiency of the active ingredients while effectively maintaining their stability. This product prolongs the duration of its effects and maintains hydration around the eyes, preventing the loss of active ingredients. The optimal combination of the base layer, drug-releasing layer, and protective film ensures the product is skin-friendly, breathable, and conforms well to the contours of the eyes, providing comfortable use without any stuffiness. The drug load is even and releases stably, allowing for slow and continuous release of active ingredients, avoiding irritation caused by excessively high local concentrations. All ingredients are selected from natural Chinese herbal extracts and medical-grade excipients, with a pH value suitable for the skin around the eyes, ensuring high safety, no allergenicity, and reliable long-term use. It effectively solves the problems of existing eye patches, such as poor targeting, low transdermal absorption efficiency, short duration of effect, and insufficient safety. It significantly improves blood circulation in the eyes, quickly relieves eye muscle fatigue and soreness, and provides an efficient and safe daily eye care solution for people who use their eyes for extended periods. Attached Figure Description

[0018] Other features, objects, and advantages of the present invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings: Figure 1 This is a schematic diagram of the structure of an eye patch that promotes blood circulation and relieves muscle soreness according to an embodiment of the present invention; Figure 2 This is a schematic flowchart illustrating a method for preparing an eye patch that promotes blood circulation and relieves muscle soreness according to an embodiment of the present invention. Detailed Implementation

[0019] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0020] The present invention will be further described in detail below with reference to the accompanying drawings.

[0021] Reference Figure 1 In a first aspect, the present invention provides an eye patch that promotes blood circulation and relieves muscle soreness, comprising a protective film layer, a drug sustained-release layer, and a substrate layer sequentially compounded from top to bottom; the drug sustained-release layer is loaded with a compound active ingredient, the compound active ingredient comprising 40-60 parts of traditional Chinese medicine extract, 5-12 parts of penetration enhancer, 2-5 parts of antioxidant, 8-15 parts of moisturizer, and 10-20 parts of deionized water; the traditional Chinese medicine extract is prepared by a gradient extraction process from Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong in a weight ratio of (3-5):(2-4):(1-3):(2-5):(3-6):(2-4):(1-2); the penetration enhancer is a compound system of menthol and laurocapram; the antioxidant is a compound system of vitamin E and glutathione; and the moisturizer is a compound system of sodium hyaluronate and glycerin.

[0022] In practice, a composite structure consisting of a protective film layer, a drug-releasing layer, and a substrate layer is used from top to bottom to form the main body of the functionally layered eye patch. The drug-releasing layer, as the core functional layer, carries a compound of active ingredients made from traditional Chinese medicine extracts, penetration enhancers, antioxidants, moisturizers, and deionized water in a specific ratio. The traditional Chinese medicine extract is made from a precise weight ratio of Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong. Through a gradient extraction process, the active ingredients of each herb are fully released to achieve synergistic effects of dilating blood vessels, reducing inflammation and pain, and protecting nerves. The penetration enhancer uses a compound system of menthol and laurocapram to break down the skin's stratum corneum barrier and accelerate the transdermal absorption of active ingredients. The antioxidant is a compound of vitamin E and glutathione to inhibit the oxidative degradation of active ingredients. The moisturizer uses a compound of sodium hyaluronate and glycerin to construct a three-dimensional moisturizing network, reducing the loss of active ingredients and maintaining the hydration of the skin around the eyes. All the ingredients work synergistically on the skin and subcutaneous tissue around the eyes to ultimately promote blood circulation and relieve muscle soreness.

[0023] This invention clarifies the core structure and ingredient ratio of the eye patch, achieving synergistic effects of multiple ingredients and multiple functions, overcoming the limitations of existing eye patches with single-ingredient efficacy. The precise compounding of multiple medicinal herbs from traditional Chinese medicine extracts specifically addresses the core pain points of poor blood circulation and muscle soreness in the eyes. The compounding system of penetration enhancers, antioxidants, and moisturizers optimizes ingredient absorption efficiency, stability, and duration of action. The layered composite structure ensures the product's ease of use and comfort. The overall ingredients are selected from natural traditional Chinese medicine extracts and medical-grade excipients, ensuring high safety. This invention effectively achieves a balance between high efficiency, stability, and safety in the eye patch, providing a precise and targeted eye care solution for people who use their eyes extensively.

[0024] In some embodiments, the weight ratio of menthol to laurocapram is (1-3):(1-2), the weight ratio of vitamin E to glutathione is (2-4):(1-3), and the weight ratio of sodium hyaluronate to glycerin is (1-2):(3-5).

[0025] In practice, menthol and laurocapram are combined in a weight ratio of (1-3):(1-2). Menthol's mild stimulating effect on the lipid bilayer of the stratum corneum is combined with laurocapram's disruptive effect on the intercellular connections of the stratum corneum, resulting in a synergistic permeation-enhancing effect that significantly improves the transdermal penetration rate of the active ingredients of traditional Chinese medicine. Vitamin E and glutathione are combined in a weight ratio of (2-4):(1-3). The fat-soluble antioxidant properties of vitamin E and the water-soluble antioxidant capacity of glutathione cover different phases of oxidation reactions, comprehensively eliminate free radicals, and extend the shelf life of active ingredients. Sodium hyaluronate and glycerin are combined in a weight ratio of (1-2):(3-5). The high water absorption capacity of sodium hyaluronate and the moisturizing and water-locking properties of glycerin form a complementary moisturizing system to maintain the skin around the eyes for a long time.

[0026] This invention optimizes the functional efficiency of excipients by precisely limiting their weight ratios, avoiding the poor efficacy caused by insufficient function or imbalanced proportions of a single excipient. The optimal combination of penetration enhancers increases transdermal penetration efficiency by 30-50% compared to single-component formulations. The ratio of antioxidants can achieve a free radical scavenging rate of up to 85%. The above-mentioned humectant ratio design achieves a 90% 24-hour humectant retention rate. All ingredients have undergone safety verification to maximize functionality while ensuring no skin irritation, further enhancing the overall performance and user experience of the eye patch.

[0027] In some embodiments, the substrate layer is a medical nonwoven fabric or hydrogel substrate, the thickness of the substrate layer is 0.1-0.3 mm, and the surface of the substrate layer has a plurality of pores with a diameter of 50-200 μm. The ventilation holes have an opening ratio of 15-30%. .

[0028] It should be noted that medical nonwoven fabric or hydrogel substrate is selected as the carrier base for the drug sustained-release layer. Both types of substrates have good skin affinity, liquid absorption, and biocompatibility, allowing for close adhesion to the skin around the eyes without any risk of sensitization. The thickness of the substrate layer is controlled between 0.1-0.3 mm, balancing the ability to carry the drug with the lightweight and comfortable feel during use. Pores are provided on the surface. Open area ratio 15-30 The ventilation holes ensure that the skin around the eyes can breathe smoothly, avoiding the stuffy and uncomfortable feeling caused by prolonged application. On the other hand, they promote gas exchange between the drug release layer and the skin, reducing the irritation caused by moisture accumulation. They also enhance the bonding between the base layer and the drug release layer, preventing the drug layer from falling off during use.

[0029] This invention solves the problems of poor skin-friendliness and insufficient breathability of traditional eye patch substrates by selecting the right material and optimizing the structure of the substrate layer. The medical-grade substrate ensures the safety of the product, the thinness improves wearing comfort, and the breathable design effectively reduces the stuffiness during application, increasing user willingness to use the product. The rational design of the substrate layer provides a stable support for the drug sustained-release layer, ensuring that the active ingredients can be evenly distributed and continuously released, indirectly improving the efficacy of the eye patch.

[0030] In some embodiments, the thickness of the drug sustained-release layer is 0.2-0.5 mm, and the loading of the composite active ingredient in the drug sustained-release layer is [missing information]. Furthermore, the in vitro release curve of the drug sustained-release layer satisfies the following condition: the cumulative release rate within 2 hours is [missing information]. The cumulative release rate within 4 hours is Cumulative release rate within 8 hours .

[0031] It should be noted that the thickness of the drug sustained-release layer is controlled between 0.2-0.5 mm, combined with... The loading of the complex active ingredients ensures sufficient drug dosage to meet the requirements of long-lasting action; through the control of material ratio and preparation process, the in vitro release curve of the drug sustained-release layer meets specific requirements, with a cumulative release rate of 40-60% within 2 hours. It rapidly releases some active ingredients to relieve immediate discomfort, with a cumulative release rate of 70-80% within 4 hours. Maintaining mid-term efficacy, cumulative release rate within 8 hours This ensures a long-lasting and sustained effect; this gradient release mode avoids skin irritation caused by excessively high drug concentrations in the early stages, while also preventing insufficient efficacy in the later stages, achieving a stable and continuous release of active ingredients.

[0032] This invention achieves on-demand drug release by precisely controlling the parameters and release characteristics of the drug sustained-release layer, solving the problems of uneven drug release and short duration of action in traditional eye patches. Initial rapid release meets immediate relief needs, mid-term stable release maintains the effect, and late-term full release ensures long-lasting eye protection, significantly improving the user experience. The reasonable matching of drug load and release characteristics avoids drug waste, improves the utilization rate of active ingredients, and reduces the irritation of high-concentration drugs to the skin around the eyes, further ensuring the safety and effectiveness of the product.

[0033] In some embodiments, the protective film is a polyethylene terephthalate film or a polyethylene film, the thickness of the protective film is 0.05-0.1 mm, and the side of the protective film away from the drug sustained-release layer is provided with an anti-slip texture.

[0034] It should be noted that polyethylene terephthalate film or polyethylene film is selected as the protective film layer. Both materials have good barrier properties, which can effectively isolate oxygen, moisture and external pollutants, prevent the active ingredients in the drug sustained-release layer from oxidation, degradation or contamination, and extend the product's shelf life. The thickness is controlled at 0.05-0.1mm, which balances the barrier protection effect with easy peeling during use, avoiding the difficulty of peeling due to excessive thickness or the failure of protection due to excessive thinness. The protective film layer has anti-slip texture on the side away from the drug sustained-release layer to increase the friction during peeling, making it easy for users to peel off the protective film quickly and smoothly, improving the convenience of use.

[0035] This invention achieves effective protection of the drug sustained-release layer and improves ease of use through the selection of materials and structural design of the protective film layer; the barrier material ensures the stability of the active ingredients during storage and extends the shelf life; the reasonable thickness design balances the protective effect and the difficulty of peeling, and the anti-slip texture optimizes the user experience; the overall design of the protective film layer ensures the stable quality of the eye patch throughout the entire process from production and storage to use, thereby enhancing the product's market competitiveness.

[0036] Reference Figure 2 The second aspect of this invention provides a method for preparing an eye patch that promotes blood circulation and relieves muscle soreness, comprising the following steps: S1. Preparation of Chinese herbal extract: Weigh out Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong according to the weight ratio, pulverize them and pass them through a 40-60 mesh sieve to obtain Chinese herbal powder; mix the Chinese herbal powder with the extraction solvent at a material-to-liquid ratio of 1:(10-20). Mix, then pass through 80-90 degrees Celsius in sequence. Hot water extraction for 1-2 hours, 60-70 Ultrasonic extraction for 30-60 min, combined extracts, filtered, and concentrated under reduced pressure to a relative density of 1.10-1.20 (25℃) to obtain the herbal extract; S2. Blending of Compound Active Ingredients: Add the penetration enhancer, antioxidant, and humectant to deionized water and stir until completely dissolved to obtain a mixed excipient solution; slowly add the herbal extract to the mixed excipient solution, and stir for 30-40 minutes. Stir at 200-300 r / min for 30-60 min, then homogenize 2-3 times with a high-pressure homogenizer at 20-30 MPa pressure to obtain the composite active ingredients; S3. Substrate pretreatment: The substrate layer is sterilized under ultraviolet light for 15-20 minutes, and then its surface is modified by plasma treatment instrument with a treatment power of 50-80W and a treatment time of 5-10 minutes. S4. Drug Loading: The composite active ingredient prepared in step S2 is uniformly coated onto the surface of the pretreated substrate layer, with a coating amount of [missing information]. Then at 40-50 Relative humidity 30-40 Dry in an environment for 10-20 minutes to form a drug sustained-release layer;

[0037] S5. Composite molding: The protective film layer is laminated onto the side of the drug sustained-release layer away from the substrate layer, and after cutting and packaging, an eye patch that promotes blood circulation and relieves muscle soreness is obtained.

[0038] The working logic of the preparation method of this invention is as follows: Step S1 adopts a gradient extraction process, first extracting water-soluble active ingredients with hot water, and then extracting fat-soluble active ingredients with ultrasound to achieve full extraction of the active ingredients of traditional Chinese medicine. Subsequently, high-concentration traditional Chinese medicine extract is obtained by vacuum concentration; Step S2 uses operations such as stirring, dissolving, mixing and homogenizing to uniformly mix the traditional Chinese medicine extract with various excipients to form a stable composite active ingredient dispersion system; Step S3 performs ultraviolet sterilization and plasma surface modification on the substrate to ensure the hygiene and safety of the substrate and improve the hydrophilicity and adhesion of the substrate surface, laying the foundation for drug loading; Step S4 uses a precise coating and gentle drying process to uniformly load the composite active ingredients on the surface of the substrate and form a stable drug sustained-release layer; Step S5 obtains the finished eye patch through composite molding and cutting and packaging. The entire process is interconnected to ensure stable product quality.

[0039] This invention achieves efficient and stable production of eye patches through a standardized and scientific preparation process design, solving the problems of low extraction efficiency, uneven ingredient mixing, and large fluctuations in product quality in traditional preparation processes. The gradient extraction process significantly improves the extraction rate of active ingredients from traditional Chinese medicine, while high-pressure homogenization and plasma modification optimize ingredient dispersibility and substrate adhesion. Parameter control throughout the process ensures product uniformity and stability, making it suitable for large-scale industrial production. The preparation process is gentle, producing no toxic or harmful substances, ensuring product safety while improving production efficiency and reducing production costs.

[0040] In some embodiments, the extraction solvent in step S1 is 40-60% by volume. The ethanol-water solution was concentrated under reduced pressure at a vacuum of 0.06-0.09 MPa and a concentration temperature of 50-60°C. It should be noted that a volume fraction of 40-60% is selected. An aqueous ethanol solution was used as the extraction solvent. This concentration range of ethanol can fully dissolve both water-soluble and some fat-soluble active ingredients in traditional Chinese medicine, enabling the simultaneous extraction of multiple types of active ingredients. The vacuum degree for vacuum concentration was controlled at 0.06-0.09 MPa, and the concentration temperature was controlled at 50-60°C. While lowering the boiling point of the system, this method avoids the oxidation, degradation, or structural damage of the active ingredients in traditional Chinese medicine caused by high temperatures, thus ensuring the content and activity of the active ingredients in the extract.

[0041] This invention further improves the quality of traditional Chinese medicine extracts by optimizing extraction solvents and concentration parameters, solving the problems of poor solvent compatibility and loss of active ingredients during concentration in traditional extraction processes. The specific concentration of ethanol aqueous solution improves the extraction efficiency and purity of active ingredients, while the gentle vacuum concentration conditions maximize the preservation of the bioactivity of active ingredients. The improved quality of the extract directly enhances the core efficacy of the eye patch, laying a high-quality foundation for the subsequent formulation of compound active ingredients, while reducing the risk of product performance fluctuations due to component degradation.

[0042] In some embodiments, the temperature of the high-pressure homogenization in step S2 is controlled at 25-35°C. During homogenization, citric acid or sodium hydroxide is used to adjust the pH of the system to 5.5-6.5. It should be noted that the temperature is controlled between 25-35°C during high-pressure homogenization. This temperature range ensures homogenization, allowing the complex active ingredients to form a uniform dispersion system of 100-500nm, while also preventing thermal degradation of the active ingredients due to high temperatures. Citric acid or sodium hydroxide is used to adjust the pH of the system to 5.5-6.5, which is close to the physiological pH of human eye skin, reducing the irritation of the complex active ingredients to the eye skin and improving the biocompatibility of the product.

[0043] This invention optimizes the stability and biocompatibility of the compound active ingredients by precisely controlling the high-pressure homogenization temperature and the pH value of the system, solving the problems of uneven ingredient dispersion and strong product irritation in traditional processes; low-temperature high-pressure homogenization ensures the stability and dispersibility of active ingredients and improves transdermal absorption efficiency; the physiologically adapted pH value design significantly reduces the risk of eye skin allergies and redness, improving the safety and comfort of product use, and is especially suitable for people with sensitive skin.

[0044] In some embodiments, the coating method in step S4 is slot coating or anilox roller coating, and the drying process uses hot air circulation drying with an air velocity of [missing information]. It should be noted that both slot coating and anilox roller coating methods can achieve uniform coating of the composite active ingredients on the substrate surface, ensuring consistent drug release layer thickness and uniform component distribution, avoiding localized excessively high or low concentrations; the drying process uses 40-50... Relative humidity 30-40 Hot air circulation drying, with the wind speed controlled at... Mild drying conditions can quickly remove moisture from the system while preventing oxidation of active ingredients or cracking of the drug release layer, ensuring a strong bond between the drug release layer and the substrate layer.

[0045] This invention solves the problems of uneven coating, poor adhesion, and component inactivation in traditional drug loading processes by optimizing the coating and drying processes. Uniform coating ensures the consistency of product efficacy and avoids local irritation or insufficient efficacy. Gentle hot air circulation drying ensures drying efficiency while maximizing the preservation of the activity of active ingredients, enhancing the adhesion between the drug sustained-release layer and the substrate layer, preventing the drug layer from falling off during use, and improving the stability and reliability of the product.

[0046] The third aspect of this invention provides the application of the aforementioned eye patch, which can be used to prepare nursing products for improving blood circulation in the eyes and relieving eye muscle fatigue and soreness. It is suitable for daily use by people who use their eyes extensively (such as office workers, students, drivers, etc.) and can also be used as an auxiliary care during post-operative eye surgery recovery. It should be noted that, based on the core efficacy of the eye patch in promoting blood circulation in the eyes and relieving eye muscle fatigue and soreness, it is applied to the preparation of related nursing products. For people who use their eyes extensively, the eye patch improves blood circulation disorders in the eyes through the transdermal absorption of active ingredients, relaxes tense eye muscles, and relieves discomfort such as dryness and soreness. For people recovering from post-operative eye surgery, its gentle ingredients and soothing effects can help improve post-operative eye microcirculation, reduce muscle tension and discomfort, and it is highly safe, without irritating the fragile post-operative eye tissues.

[0047] This invention clarifies the application scope of eye patches, expands the market application scenarios of the product, and solves the problem of the single application scenario of existing eye patches; its targeted efficacy is adapted to the core needs of people who use their eyes for long periods of time and people recovering from eye surgery, providing precise eye care solutions for different groups; the clear application scenarios help users quickly identify the product value, improve the market recognition of the product, and at the same time provide an efficient and safe core carrier for the development of related care products, promoting the diversified development of eye care products.

[0048] To provide a clearer understanding of the invention, the invention is further described below: In a first aspect, this application provides an eye patch that promotes blood circulation and relieves muscle soreness. The eye patch comprises a protective film layer, a drug sustained-release layer, and a substrate layer, which are sequentially composited from top to bottom. The drug sustained-release layer is loaded with a composite active ingredient, which includes 40-60 parts of traditional Chinese medicine extract, 5-12 parts of penetration enhancer, 2-5 parts of antioxidant, 8-15 parts of moisturizer, and 10-20 parts of deionized water. The traditional Chinese medicine extract is prepared by gradient extraction of Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong in a weight ratio of (3-5):(2-4):(1-3):(2-5):(3-6):(2-4):(1-2). The penetration enhancer is a compound system of menthol and laurocapram, the antioxidant is a compound system of vitamin E and glutathione, and the moisturizer is a compound system of sodium hyaluronate and glycerin.

[0049] In this application, the herbal extract uses a compound of multiple Chinese herbs, with each component acting synergistically: ferulic acid from Angelica sinensis and tanshinone from Salvia miltiorrhiza. It can dilate capillaries in the eyes, reduce blood viscosity, and promote blood circulation; menthol in peppermint and apigenin in chamomile can inhibit inflammatory factors (such as... The release of IL-6 relieves muscle inflammation and soreness; the polysaccharides in wolfberry and the rhein in cassia seed can protect retinal nerve cells and improve eye metabolism; the tetramethylpyrazine in chuanxiong can improve microcirculation and enhance the transport efficiency of other active ingredients. By combining them in a specific weight ratio, a synergistic effect of promoting circulation, reducing inflammation and pain, and protecting nerves can be achieved.

[0050] The penetration enhancer is a combination of menthol and laurocapram. Menthol gently stimulates the lipid bilayer of the stratum corneum, while laurocapram disrupts the intercellular connections of the stratum corneum. The synergistic effect of these two ingredients significantly increases the transdermal penetration rate of the active ingredients in traditional Chinese medicine, and its enhanced penetration effect meets the requirements of… (Where P is the transdermal permeability coefficient, C1 is the menthol concentration, C2 is the laurocapram concentration, and k1, k2, and k3 are synergistic coefficients). Experiments have verified that the permeability of this compound system is 30-50% higher than that of a single permeability enhancer. .

[0051] The antioxidant combination of vitamin E and glutathione can be used to achieve OFR clearance rate = (1-A / A0)100 (Where A is the absorbance of the system with added antioxidant, and A0 is the absorbance of the system without added antioxidant.) Calculations show that its free radical scavenging rate can reach 85%. The above can effectively inhibit the oxidative degradation of active ingredients in traditional Chinese medicine and extend the product's shelf life; the moisturizer uses a combination of sodium hyaluronate and glycerin to form a three-dimensional moisturizing network, and the moisturizing rate is calculated as (M1-M0) / M0 × 100. (Where M0 is the mass of the sample after drying, and M1 is the mass of the sample after moisturizing treatment) Calculated, its 24-hour moisturizing rate is 90%. It can maintain the hydration of the skin around the eyes and reduce the loss of active ingredients.

[0052] Preferably, the weight ratio of menthol to laurocapram is (1-3):(1-2), which has the best penetration-enhancing effect and no skin irritation; the weight ratio of vitamin E to glutathione is (2-4):(1-3), which can achieve a balance between antioxidant effect and safety; the weight ratio of sodium hyaluronate to glycerin is (1-2):(3-5), which can take into account both long-lasting moisturizing effect and skin compatibility.

[0053] Preferably, the substrate layer is a medical nonwoven fabric or hydrogel substrate with a thickness of 0.1-0.3 mm and a plurality of pores with a diameter of 50-200 μm on its surface. The ventilation holes have an opening ratio of 15-30%. Medical nonwoven fabric or hydrogel substrate has good skin affinity and liquid absorption. The design of the pores can ensure that the skin around the eyes can breathe smoothly and avoid stuffiness and discomfort. At the same time, it can help the drug release layer to adhere closely to the skin and improve the absorption efficiency of active ingredients.

[0054] Preferably, the thickness of the drug sustained-release layer is 0.2-0.5 mm, and the loading of the composite active ingredient is [missing information]. Its in vitro release curve meets the following condition: the cumulative release rate within 2 hours is 40-60%. The cumulative release rate within 4 hours is 70-85%. Cumulative release rate within 8 hours This release characteristic enables the slow and continuous release of active ingredients, avoiding irritation caused by excessively high initial concentrations, while ensuring a long-term supply of medication and continuously relieving eye discomfort.

[0055] Preferably, the protective film layer is a polyethylene terephthalate film or a polyethylene film with a thickness of 0.05-0.1 mm, and the side away from the drug release layer has an anti-slip texture. The protective film layer can effectively protect the drug release layer, prevent the loss and contamination of active ingredients, and the anti-slip texture design makes it easy to peel off during use, improving the user experience.

[0056] Secondly, this application provides a method for preparing an eye patch that promotes blood circulation and relieves muscle soreness, the method comprising the following steps: S1. Preparation of Traditional Chinese Medicine Extract: Weigh out Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong according to the weight ratio, pulverize them, and pass them through a 40-60 mesh sieve to obtain traditional Chinese medicine powder; mix the traditional Chinese medicine powder with the extraction solvent at a material-to-liquid ratio of 1:(10-20) g / mL, and sift through an 80-90 mesh sieve successively. Hot water extraction for 1-2 hours, 60-70 Ultrasonic extraction for 30-60 min, combined extracts, filtered, and concentrated under reduced pressure to a relative density of 1.10-1.20 (25%). ), to obtain the Chinese herbal extract.

[0057] A gradient extraction process is employed, firstly using hot water extraction to dissolve water-soluble active ingredients (such as wolfberry polysaccharides and hyaluronic acid), and then using ultrasonic extraction (ultrasonic power 200-300W) to disrupt the plant cell walls and release fat-soluble active ingredients (such as tanshinone). Extraction solvents such as menthol and menthol can significantly improve extraction efficiency. An extraction solvent with a volume fraction of 40-60% is recommended. An aqueous solution of ethanol can dissolve both water-soluble and some fat-soluble components, with minimal damage to the active ingredients of traditional Chinese medicine. The vacuum degree for reduced pressure concentration is 0.06-0.09 MPa, and the concentration temperature is 50-60°C. It can be rapidly concentrated at lower temperatures, avoiding degradation of active ingredients due to high temperatures.

[0058] S2. Blending of Compound Active Ingredients: Add the penetration enhancer, antioxidant, and humectant to deionized water and stir until completely dissolved to obtain a mixed excipient solution; slowly add the herbal extract to the mixed excipient solution, and stir for 30-40 minutes. Stir at 200-300 r / min for 30-60 min, then homogenize 2-3 times at 20-30 MPa using a high-pressure homogenizer to obtain the composite active ingredients.

[0059] Temperature is controlled at 25-35°C during high-pressure homogenization. This process prevents thermal degradation of the active ingredients. The pH of the system is adjusted to 5.5-6.5 using citric acid or sodium hydroxide, a pH value close to that of the skin around the eyes, reducing irritation. High-pressure homogenization ensures a uniform and stable dispersion of the complex active ingredients, with particle sizes controlled between 100-500 nm, which improves transdermal absorption efficiency. The particle size distribution meets the D90 standard. 500nm (D90 is a cumulative 90) Particle size.

[0060] S3. Substrate pretreatment: The substrate layer is sterilized under ultraviolet light for 15-20 minutes, and then its surface is modified by plasma treatment instrument with a treatment power of 50-80W and a treatment time of 5-10 minutes.

[0061] Ultraviolet sterilization can effectively kill microorganisms on the surface of the substrate, ensuring product safety; plasma treatment can introduce polar groups such as hydroxyl and carboxyl groups, improve the hydrophilicity and adhesion of the substrate surface, and make the drug sustained-release layer bond more firmly with the substrate layer, preventing it from falling off during use.

[0062] S4. Drug Loading: The composite active ingredient prepared in step S2 is uniformly coated onto the surface of the pretreated substrate layer, with a coating amount of [missing information]. Then at 40-50 Relative humidity 30-40 Dry in an environment for 10-20 minutes to form a drug sustained-release layer.

[0063] The coating method employs slot coating or anilox roller coating to ensure uniform coating and avoid localized areas of excessively high or low concentration. Hot air circulation drying (wind speed 1-2 m / s) rapidly removes moisture from the system while preventing oxidation of active ingredients. The moisture content of the dried drug sustained-release layer is controlled at 5-10%. This ensures the stability of the active ingredients and allows for rapid swelling and release during use.

[0064] S5. Composite molding: The protective film layer is laminated onto the side of the drug sustained-release layer away from the substrate layer, and after cutting and packaging, an eye patch that promotes blood circulation and relieves muscle soreness is obtained.

[0065] The cutting size is designed according to the contour of the human eye to ensure a close fit to the skin around the eyes. The packaging uses an aluminum foil bag for vacuum sealing, which can isolate oxygen and moisture and extend the product's shelf life.

[0066] To better understand the technical solution of this application, the technical solution of this application will be described in detail below with reference to specific embodiments.

[0067] Example 1: An eye patch that promotes blood circulation and relieves muscle soreness comprises the following compound active ingredients: 40 parts of traditional Chinese medicine extract, 5 parts of penetration enhancer (menthol: laurocapram = 1:1), 2 parts of antioxidant (vitamin E: glutathione = 2:1), 8 parts of moisturizer (sodium hyaluronate: glycerin = 1:3), and 10 parts of deionized water. The traditional Chinese medicine extract is prepared from 3 parts of Angelica sinensis, 2 parts of Salvia miltiorrhiza, 1 part of peppermint, 2 parts of chamomile, 3 parts of wolfberry, 2 parts of cassia seed, and 1 part of Ligusticum chuanxiong. The base layer is a medical non-woven fabric with a thickness of 0.1 mm and breathable pore size. Open area ratio 15 The drug-release layer is 0.2 mm thick and has a loading capacity of 1. The protective film is a polyethylene terephthalate film with a thickness of 0.05 mm.

[0068] The preparation method includes: S1. Preparing the herbal extract: Weigh the above-mentioned parts by weight of the herbal raw materials, pulverize them and pass them through a 40-mesh sieve, and mix them with a volume fraction of 40... The ethanol-water solution was mixed at a material-to-liquid ratio of 1:10 g / mL, 80 Hot water extraction for 1 hour, 60 Ultrasonic extraction was performed for 30 minutes (ultrasonic power 200W). The extracts were combined, filtered, and then subjected to a vacuum of 0.06MPa at 50°C. Concentrate under reduced pressure to a relative density of 1.10 (25 ppm) under these conditions. S2. Preparation of compound active ingredients: Add penetration enhancer, antioxidant, and moisturizer to deionized water, stir to dissolve, then add the herbal extract, 30 Stir at 200 rpm for 30 minutes, then at 20 MPa and 25 °C. Under high-pressure homogenization for two cycles, the pH value was adjusted to 5.5 to obtain the composite active ingredient; S3. Substrate pretreatment: Medical nonwoven fabric was sterilized with ultraviolet light for 15 min and treated with a 50W plasma treatment instrument for 5 min; S4. Drug loading: The composite active ingredient was coated onto the surface of the substrate layer using slit coating, and the coating amount was... , at 40 Relative humidity 30 Dry in hot air in the environment (wind speed 1m / s) for 10min; S5. Composite molding: Composite polyethylene terephthalate film, cut and vacuum sealed to obtain eye patch.

[0069] Example 2: An eye patch that promotes blood circulation and relieves muscle soreness comprises the following compound active ingredients: 50 parts of traditional Chinese medicine extract, 8 parts of penetration enhancer (menthol: laurocapram = 2: 1.5), 3 parts of antioxidant (vitamin E: glutathione = 3: 2), 12 parts of moisturizer (sodium hyaluronate: glycerin = 1.5: 4), and 15 parts of deionized water; the traditional Chinese medicine extract is prepared from 4 parts of Angelica sinensis, 3 parts of Salvia miltiorrhiza, 2 parts of peppermint, 3 parts of chamomile, 4.5 parts of wolfberry, 3 parts of cassia seed, and 1.5 parts of Ligusticum chuanxiong; the base layer is a hydrogel base with a thickness of 0.2 mm and a breathable pore size. Open area ratio 22 The drug-release layer thickness is 0.35 mm, and the loading capacity is... The protective film is a polyethylene film with a thickness of 0.08 mm.

[0070] The preparation method includes: S1. Preparing the herbal extract: Weigh the above-mentioned parts by weight of the herbal raw materials, pulverize them and pass them through a 50-mesh sieve, and mix them with 50% by volume. The ethanol-water solution was mixed at a material-to-liquid ratio of 1:15 g / mL, 85 Hot water extraction for 1.5 h, followed by ultrasonic extraction at 65℃ for 45 min (ultrasonic power 250W). The extracts were combined, filtered, and then subjected to a vacuum of 0.075 MPa at 55℃. Concentrate under reduced pressure to a relative density of 1.15 (25) under the specified conditions. S2. Preparation of compound active ingredients: Add penetration enhancer, antioxidant, and moisturizer to deionized water, stir to dissolve, then add the herbal extract, 35 Stir at 250 rpm for 45 minutes, then at 25 MPa and 30 °C. Under high pressure homogenization for 3 times, the pH value was adjusted to 6.0 to obtain the composite active ingredient; S3. Substrate pretreatment: The hydrogel substrate was sterilized with ultraviolet light for 18 min and treated with a 65W plasma treatment instrument for 8 min; S4. Drug loading: The composite active ingredient was coated onto the surface of the substrate layer using an anilox roller coating method, with a coating amount of... , at 45 Relative humidity 35 Dry with hot air in the environment (wind speed 1.5m / s) for 15min; S5. Composite molding: Composite polyethylene film, cut and vacuum sealed to obtain eye patch.

[0071] Example 3: An eye patch that promotes blood circulation and relieves muscle soreness comprises the following compound active ingredients: 60 parts of traditional Chinese medicine extract, 12 parts of penetration enhancer (menthol: laurocapram = 3: 2), 5 parts of antioxidant (vitamin E: glutathione = 4: 3), 15 parts of moisturizer (sodium hyaluronate: glycerin = 2: 5), and 20 parts of deionized water. The traditional Chinese medicine extract is prepared from 5 parts of Angelica sinensis, 4 parts of Salvia miltiorrhiza, 3 parts of peppermint, 5 parts of chamomile, 6 parts of wolfberry, 4 parts of cassia seed, and 2 parts of Ligusticum chuanxiong. The base layer is a medical non-woven fabric with a thickness of 0.3 mm and breathable pore size. Open area ratio 30 The drug-release layer is 0.5 mm thick and has a loading capacity of [missing information]. The protective film is a polyethylene terephthalate film with a thickness of 0.1 mm.

[0072] The preparation method includes: S1. Preparing the herbal extract: Weigh the above-mentioned parts by weight of the herbal raw materials, pulverize them and pass them through a 60-mesh sieve, and mix them with a volume fraction of 60... The ethanol-water solution was mixed at a material-to-liquid ratio of 1:20 g / mL, 90 Hot water extraction for 2 hours, 70 Ultrasonic extraction was performed for 60 minutes (ultrasonic power 300W). The extracts were combined, filtered, and then subjected to a vacuum of 0.09 MPa at 60°C. Concentrate under reduced pressure to a relative density of 1.20 (25 ppm) under these conditions. S2. Preparation of compound active ingredients: Add penetration enhancer, antioxidant, and moisturizer to deionized water, stir to dissolve, then add the herbal extract, 40 Stir at 300 rpm for 60 minutes, then at 30 MPa and 35 °C. Under high-pressure homogenization for 3 times, the pH value was adjusted to 6.5 to obtain the composite active ingredient; S3. Substrate pretreatment: Medical nonwoven fabric was sterilized with ultraviolet light for 20 min and treated with an 80W plasma treatment instrument for 10 min; S4. Drug loading: The composite active ingredient was coated onto the surface of the substrate layer using slit coating, and the coating amount was... , in 50 Relative humidity 40 Dry in hot air (wind speed 2m / s) for 20min; S5. Composite molding: Composite polyethylene terephthalate film, cut and vacuum sealed to obtain eye patch.

[0073] Effect verification experiment Experiment to promote blood circulation: Sixty volunteers with poor blood circulation in their eyes due to prolonged eye strain were randomly divided into three groups. Each group used the eye patches prepared in Examples 1-3, once daily for 30 minutes each time, for 7 consecutive days. Laser Doppler flowmetry was used to measure the blood flow to the eye skin before and after use. The results showed that the blood flow to the eye skin increased by 42% after use compared to before use. 53 48 This indicates that the eye patch of this application can effectively promote blood circulation in the eyes.

[0074] Experiment on relieving muscle soreness: Sixty volunteers with eye muscle soreness were randomly divided into three groups. Each group used the eye patches prepared in Examples 1-3, once daily for 30 minutes each time, for three consecutive days. The visual analog scale (VAS) was used to assess the degree of soreness. The results showed that the VAS scores decreased by 38% after use compared to before use. 51 46 This indicates that the eye patch of this application can significantly relieve eye muscle soreness.

[0075] Safety experiment: Thirty healthy volunteers were selected to conduct a skin irritation experiment on the inside of their arms. The eye patch prepared in Example 2 was applied for 24 hours and the skin reaction was observed. The results showed that none of the volunteers had any irritation reactions such as redness, swelling, or itching. The primary irritation index (PII) was 0.3, indicating that the eye patch of this application has high safety.

[0076] The above experimental results show that the eye patch that promotes blood circulation and relieves muscle soreness has significant efficacy and high safety, and can meet the eye care needs of people who use their eyes for long periods of time.

[0077] The technical solutions provided by the embodiments disclosed in this application have the following beneficial effects: Significantly enhanced efficacy: The eye patch of this application uses a compound of multiple traditional Chinese medicines to prepare a herbal extract. Each herbal component works synergistically to promote blood circulation and relieve muscle soreness. Simultaneously, it is combined with a compound penetration enhancer, antioxidant, and moisturizer to achieve synergistic effects in active ingredients, efficacy, and dosage form. Compared to existing single-component eye patches, it improves the efficiency of promoting blood circulation in the eyes by 40-60%. Muscle soreness relief rate increased by 35-50%. .

[0078] High transdermal absorption efficiency: The combination of a penetration enhancer compound system and a high-pressure homogenization process increases the transdermal permeability coefficient of the compound active ingredients by 30-50%. Furthermore, the drug sustained-release layer has ideal in vitro release characteristics, enabling continuous and stable release of active ingredients, with a duration of efficacy of up to 8-12 hours.

[0079] High safety: The eye patch of this application uses natural Chinese herbal extracts as the main active ingredients, and the auxiliary materials are all medical-grade raw materials. The pH value is compatible with the skin around the eyes. It has been verified by skin irritation test that the primary irritation index (PII) is low. It is non-allergenic and safe and reliable for long-term use.

[0080] Scientific preparation process: Gradient extraction, high pressure homogenization, plasma modification and other processes can effectively improve the extraction rate of active ingredients, system stability and substrate adhesion. The preparation process is mild and does not produce toxic or harmful substances, making it suitable for industrial production.

[0081] The technical solutions provided by the embodiments of the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the embodiments of the present invention. The descriptions of the embodiments above are only for helping to understand the principles of the embodiments of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the embodiments of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. An eye patch that promotes blood circulation and relieves muscle soreness, characterized in that: The product comprises, from top to bottom, a protective film layer, a drug sustained-release layer, and a substrate layer. The drug sustained-release layer is loaded with a complex active ingredient, which includes 40-60 parts of traditional Chinese medicine extract, 5-12 parts of penetration enhancer, 2-5 parts of antioxidant, 8-15 parts of moisturizer, and 10-20 parts of deionized water. The traditional Chinese medicine extract is prepared by gradient extraction of Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong in a weight ratio of (3-5):(2-4):(1-3):(2-5):(3-6):(2-4):(1-2). The penetration enhancer is a compound system of menthol and laurocapram, the antioxidant is a compound system of vitamin E and glutathione, and the moisturizer is a compound system of sodium hyaluronate and glycerin.

2. The eye patch for promoting blood circulation and relieving muscle soreness according to claim 1, characterized in that: The weight ratio of menthol to laurocapram is (1-3):(1-2), the weight ratio of vitamin E to glutathione is (2-4):(1-3), and the weight ratio of sodium hyaluronate to glycerin is (1-2):(3-5).

3. The eye patch for promoting blood circulation and relieving muscle soreness according to claim 1, characterized in that: The substrate layer is a medical nonwoven fabric or hydrogel substrate, the thickness of the substrate layer is 0.1-0.3 mm, and the surface of the substrate layer has a plurality of pores with a diameter of 50-200 μm. The ventilation holes have an opening ratio of 15-30%. .

4. The eye patch for promoting blood circulation and relieving muscle soreness according to claim 1, characterized in that: The thickness of the drug sustained-release layer is 0.2-0.5 mm, and the loading of the composite active ingredient in the drug sustained-release layer is... Furthermore, the in vitro release curve of the drug sustained-release layer satisfies the following condition: the cumulative release rate within 2 hours is [missing information]. The cumulative release rate within 4 hours is Cumulative release rate within 8 hours .

5. The eye patch for promoting blood circulation and relieving muscle soreness according to claim 1, characterized in that: The protective film is a polyethylene terephthalate film or a polyethylene film, the thickness of the protective film is 0.05-0.1 mm, and the side of the protective film away from the drug sustained-release layer has an anti-slip texture.

6. A method for preparing an eye patch that promotes blood circulation and relieves muscle soreness, characterized in that, Includes the following steps: S1. Preparation of Chinese herbal extract: Weigh out Angelica sinensis, Salvia miltiorrhiza, Mentha haplocalyx, Chamomile, Lycium barbarum, Cassia tora, and Ligusticum chuanxiong according to the weight ratio, pulverize them and pass them through a 40-60 mesh sieve to obtain Chinese herbal powder; mix the Chinese herbal powder with the extraction solvent at a material-to-liquid ratio of 1:(10-20). Mix, then pass through 80-90 degrees Celsius in sequence. Hot water extraction for 1-2 hours, 60-70 minutes Ultrasonic extraction for 30-60 min, combined extracts, filtered, and concentrated under reduced pressure to a relative density of 1.10-1.20 to obtain the herbal extract; S2. Blending of Compound Active Ingredients: Add the penetration enhancer, antioxidant, and humectant to deionized water and stir until completely dissolved to obtain a mixed excipient solution; slowly add the herbal extract to the mixed excipient solution, and stir for 30-40 minutes. Stir at 200-300 r / min for 30-60 min, then homogenize 2-3 times at 20-30 MPa using a high-pressure homogenizer to obtain the composite active ingredients; S3. Substrate pretreatment: The substrate layer is sterilized under ultraviolet light for 15-20 minutes, and then its surface is modified by plasma treatment instrument with a treatment power of 50-80W and a treatment time of 5-10 minutes. S4. Drug Loading: The composite active ingredient prepared in step S2 is uniformly coated onto the surface of the pretreated substrate layer, with a coating amount of [missing information]. Then at 40-50 Relative humidity 30-40 Dry in an environment for 10-20 minutes to form a drug sustained-release layer; S5. Composite molding: The protective film layer is laminated onto the side of the drug sustained-release layer away from the substrate layer, and after cutting and packaging, an eye patch that promotes blood circulation and relieves muscle soreness is obtained.

7. The method for preparing the eye patch for promoting blood circulation and relieving muscle soreness according to claim 6, characterized in that: The extraction solvent in step S1 has a volume fraction of 40-60%. The ethanol-water solution was concentrated under reduced pressure at a vacuum of 0.06-0.09 MPa and a concentration temperature of 50-60°C. .

8. The method for preparing the eye patch for promoting blood circulation and relieving muscle soreness according to claim 6, characterized in that: In step S2, the temperature of the high-pressure homogenization is controlled at 25-35°C. During homogenization, citric acid or sodium hydroxide is used to adjust the pH of the system to 5.5-6.

5.

9. The method for preparing the eye patch for promoting blood circulation and relieving muscle soreness according to claim 6, characterized in that: In step S4, the coating method uses slot coating or anilox roller coating, and the drying process uses hot air circulation drying with an air velocity of [missing information]. .

10. The use of the eye patch for promoting blood circulation and relieving muscle soreness as described in any one of claims 1-5 in the preparation of a care product for improving blood circulation in the eyes and relieving eye muscle fatigue and soreness.

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