Buccal product

Abstract

The oral product comprises a capsule and a filler surrounding the capsule, the capsule comprises a core liquid and a skin film wrapping the core liquid, the ratio of the water activity of the skin film to the water activity of the filler is larger than 0.50 and smaller than 0.90, and the thickness of the skin film ranges from 80 micrometers to 120 micrometers. After the buccal product enters the oral cavity for 5-15 minutes, the capsule is released, accurate delayed release of the capsule in the buccal product can be achieved, and the buccal product can still provide continuous flavor and has good storage stability in the later use period.

Description

Technical Field

[0001] This invention relates to the field of food technology, and more particularly to a mouth-held product. Background Technology

[0002] Oral lozenges are gaining increasing acceptance among consumers worldwide due to their safety and convenience. Adding capsules to oral lozenges can prolong the duration of their flavor.

[0003] However, existing oral products struggle to achieve precise control over capsule release time and suffer from poor stability, often failing to provide sustained flavor in the later stages of use. Summary of the Invention

[0004] To address the aforementioned technical problems, embodiments of the present invention provide a mouth-held product.

[0005] To achieve the above objectives, embodiments of the present invention relate to an oral product comprising a capsule and a filler surrounding the capsule. The capsule comprises a core liquid and a membrane covering the core liquid. The ratio of the water activity of the membrane to the water activity of the filler is greater than 0.50 and less than 0.90, and the thickness of the membrane is 80 μm to 120 μm.

[0006] In some embodiments, the water activity of the membrane is 0.2 to 0.9.

[0007] In some embodiments, the water activity of the membrane is 0.3 to 0.8.

[0008] In some embodiments, the water activity of the membrane is 0.5 to 0.7.

[0009] In some embodiments, the water activity of the filler is 0.6 to 0.99.

[0010] In some embodiments, the film comprises a colloidal substance and a curing agent.

[0011] In some embodiments, the filler comprises one or more of microcrystalline cellulose, plant fiber, or starch derivative and water.

[0012] In some embodiments, the oral product comprises multiple capsules, the thickness of which is not entirely the same.

[0013] In some embodiments, the core fluid contains flavoring agents and / or active ingredients.

[0014] In some embodiments, the oral product comprises multiple capsules, the core liquid of which contains the same or different flavorings and / or active ingredients.

[0015] In some embodiments, the oral product is a mouth bag.

[0016] In some embodiments, the capsule is released 5 to 15 minutes after the oral product is ingested.

[0017] The oral product of this application releases the capsule 5 to 15 minutes after entering the mouth, which can help achieve precise delayed release of the capsule in the oral product, and help the oral product continue to provide flavor and have good storage stability in the later stages of use.

[0018] Where technical conditions permit, the technical solutions of the various embodiments in this application can be combined in any way.

[0019] The present application will be further described below with reference to the accompanying drawings. The same or similar reference numerals may be used in the drawings to refer to the same or similar elements, devices, shapes, structures, and steps in different embodiments, and descriptions of the same or similar elements, devices, shapes, structures, steps, features, and effects in different embodiments, as well as descriptions of elements, devices, shapes, structures, steps, features, and effects that are the same or similar to those in the prior art, may be omitted. Attached Figure Description

[0020] Figure 1 Release curves for capsules with different membrane thicknesses in Example 1;

[0021] Figure 2 Release curves of capsules with different membrane thicknesses in Example 2; and

[0022] Figure 3 The release curves are for capsules with different membrane thicknesses in Example 3. Detailed Implementation

[0023] This invention relates to an oral product comprising a capsule and a filler surrounding the capsule. The capsule includes a core liquid and a membrane covering the core liquid. The ratio of the water activity of the membrane to the water activity of the filler is greater than 0.50 and less than 0.90, and the thickness of the membrane is 80 μm to 120 μm.

[0024] In this embodiment of the application, the oral product can be any product suitable for oral use, as long as it is applicable to the present invention.

[0025] Oral products may include capsules and a filling material surrounding the capsules. Capsules may include a core liquid and a membrane covering the core liquid. When the oral product is used in the mouth, as saliva seeps in, the moisture in the filling material increases, causing the membrane to absorb water, rupture, and release the core liquid, thus providing the user with a flavor sensation.

[0026] The ratio of the water activity of the membrane to that of the filler is greater than 0.50 and less than 0.90, which prevents moisture from migrating from the filler to the membrane during the storage of the oral product, thus helping to maintain the stability of the oral product.

[0027] Furthermore, a water activity ratio of the membrane to the filler greater than 0.50 contributes to good membrane toughness, helping to prevent membrane breakage during subsequent processes. A water activity ratio of the membrane to the filler less than 0.90 helps prevent the membrane from softening due to excessive water content, thus helping to maintain a good capsule shape.

[0028] Furthermore, the film thickness of 80 μm to 120 μm facilitates capsule release of the oral product at a precise time of 5 to 15 minutes after it enters the mouth, thus providing sustained flavor even in the later stages of oral product use.

[0029] The capsule's core liquid may contain flavoring agents and / or active ingredients, as well as solvents. Solvents may include medium-chain triglycerides (MCTs), olive oil, coconut oil, corn oil, soybean oil, and other vegetable oils.

[0030] The capsule membrane may contain colloidal substances and curing agents. The colloidal substances cross-link under the action of the curing agent, which can help stabilize the shape of the membrane and even the capsule.

[0031] The filler can be, for example, granular, and is used to regulate the moisture content inside the oral product. Specifically, after the oral product is used in the mouth, the filler absorbs moisture from saliva and forces the capsule membrane to absorb water, rupture, and release the core fluid.

[0032] In some embodiments, the water activity of the membrane is 0.2 to 0.9.

[0033] In some embodiments, the water activity of the membrane is 0.3 to 0.8.

[0034] In some embodiments, the water activity of the membrane is 0.5 to 0.7.

[0035] In some embodiments, the water activity of the filler is 0.6 to 0.99.

[0036] This helps prevent moisture from migrating from the filler to the capsule membrane during storage, thus helping the membrane, capsule, and even the oral product to remain stable during storage.

[0037] In some embodiments, the film comprises a colloidal substance, a curing agent, and water.

[0038] Colloidal substances may include one or more of plant gums, animal gums, and microbial gums.

[0039] Plant-based gums may include, for example, carrageenan, sodium alginate, gellan gum, pectin, cellulose gum, etc. Animal-based gums may include, for example, gelatin, chitosan, etc. Microbial gums may include, for example, gellan gum, xanthan gum, pullulan, etc. The membrane may initially be a solution of one or more of these plant-based, animal-based, or microbial gums dissolved in water with a curing agent. After the solution and core liquid form a capsule, the capsule can be dried. The outermost layer of the dried capsule is the final membrane.

[0040] The curing agent can be a polyol, such as glycerol or sorbitol.

[0041] In some embodiments, the adhesive solution used to prepare the film may contain 0.01% to 6% carrageenan, 0.01% to 5% sodium alginate, 1% to 10% gelatin, 1% to 15% glycerol, 1% to 3% cellulose gum and the balance water, based on the total weight of the adhesive solution used to prepare the film.

[0042] In some embodiments, the core fluid accounts for 70% to 90% of the capsule weight, and the membrane accounts for 10% to 30% of the capsule weight.

[0043] In some embodiments, the diameter of the capsule is 0.1 mm to 6 mm.

[0044] This allows for a better fit between the capsule and the oral product.

[0045] In some embodiments, the filler comprises one or more of microcrystalline cellulose, plant fiber, or starch derivative and water.

[0046] This allows the filling material to help regulate the moisture balance inside the oral product.

[0047] In some embodiments, the oral product comprises multiple capsules, the thickness of which is not entirely the same.

[0048] Multiple capsules with varying film thicknesses can release their flavor at different times after ingestion. Oral products comprising multiple capsules with varying film thicknesses can provide sustained flavor at different times or over a longer period. For example, an oral product may include three capsules with film thicknesses of 80 μm, 100 μm, and 120 μm, respectively. After the oral product enters the mouth, these three capsules may release their flavor at 5 minutes, 10 minutes, and 15 minutes, respectively, thus providing sustained flavor even in the later stages of use.

[0049] In some embodiments, the core fluid contains flavoring agents and / or active ingredients.

[0050] Based on the total weight of the core liquid (100%), the core liquid may contain 1% to 10% by weight of flavoring agents and / or active ingredients, and 90% to 99% by weight of solvents.

[0051] The active ingredient may be one or more of the following: nicotine and its salts, arecoline, caffeine, antioxidants, vitamins, amino acids, etc.

[0052] When a lozenge comprises multiple capsules, the core liquids of the capsules may contain the same or different flavorings and / or active ingredients. For example, a lozenge may include three capsules, each containing a mint, lemon, and citrus flavoring, respectively. When these three capsules are released individually, the lozenge may provide one or more combinations of the flavors of mint, lemon, and citrus. For instance, if the film thicknesses of the three capsules are 80 μm, 100 μm, and 120 μm, respectively, the capsules may release after 5 minutes, 10 minutes, and 15 minutes after the lozenge enters the mouth, respectively, thus providing a sustained mint, lemon, and citrus flavor even in the later stages of use. If the film thickness of the three capsules is the same, for example, all 100 μm, the capsules will release simultaneously after 10 minutes after the lozenge enters the mouth, providing a sustained mixed flavor of mint, lemon, and citrus even in the later stages of use.

[0053] In some embodiments, the oral product is a mouth bag.

[0054] Oral pouches may include nicotine pouches, arecoline pouches, caffeine pouches, etc.

[0055] In some embodiments, the capsule is released 5 to 15 minutes after the oral product is ingested.

[0056] This allows the oral product to continue to provide flavor even in the later stages of use.

[0057] The embodiments of the present invention will be illustrated below with specific examples. These examples are for illustrative purposes only and are not intended to limit the scope of protection of the present invention.

[0058] Example

[0059] Example 1

[0060] 1) Preparation of capsules with different membrane thicknesses

[0061] Based on 100% by weight of the gelatin solution used to prepare the film, 15% by weight of gelatin, 1% by weight of carrageenan, 2% by weight of gellan gum, 10% by weight of glycerin, and 72% by weight of water were mixed at room temperature to form the film gelatin solution. Based on 100% by weight of the core solution, 95% by weight of MCT and 5% by weight of menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film gelatin solution and core solution at different weight ratios of 1, 1.2, and 1.4, respectively, and then at 25°C. o C±2 o C. The capsules were dried at an ambient humidity of 35%±5% RH until the water activity (As) of the capsule membrane was measured to be 0.53 using a Shibata water activity meter (HX204), resulting in capsules with a diameter of 3.5 mm. The membrane thickness of the capsules was measured at four points (top, bottom, left, and right) using an imaging device, and the average value was calculated to obtain membrane thicknesses of 80 μm, 100 μm, and 120 μm, respectively.

[0062] 2) Preparation of filler

[0063] The filler was prepared by mixing 60 wt% microcrystalline cellulose (MCC), 10 wt% guar gum, and 30 wt% water at room temperature, based on 100% of the filler weight. The water activity (Ap) of the filler was measured to be 0.90 using a Shibata water activity meter (HX204).

[0064] 3) Preparation of oral products

[0065] One capsule each of the membranes prepared in step 1) with thicknesses of 80 μm, 100 μm, and 120 μm was added to the filler prepared in step 2), making the total weight of the filler and one capsule 400 mg. The total weight of the filler and one capsule was then placed into a non-woven bag (28 mm × 15 mm) to prepare an oral product with As / Ap = 0.59.

[0066] A simulated human oral dissolution test was conducted, and the menthol release curves of the prepared oral products were tested using gas chromatography-mass spectrometry (GC-MS). Figure 1 As shown. Figure 1 In the diagram, release1 represents the release curve of a capsule with a membrane thickness of 80 μm; release2 represents the release curve of a capsule with a membrane thickness of 100 μm; and release3 represents the release curve of a capsule with a membrane thickness of 120 μm.

[0067] Example 2

[0068] 1) Preparation of capsules with different membrane thicknesses

[0069] Based on 100% by weight of the adhesive solution used to prepare the film, 1.5 wt% carrageenan, 2 wt% gellan gum, 3 wt% hydroxypropyl methylcellulose (HPMC), 10 wt% glycerol, and 84.5 wt% water were mixed at room temperature to form the film adhesive solution. Based on 100% by weight of the core solution, 95 wt% MCT and 5 wt% menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film adhesive solution and core solution at different weight ratios of 1, 1.2, and 1.4, respectively, and then at 25°C. o C±2 o C. The capsules were dried at an ambient humidity of 35%±5%RH until the water activity (As) of the capsule membrane was measured to be 0.64 using a Shibata water activity meter (HX204), resulting in capsules with a diameter of 3.5 mm. The membrane thickness of the capsules was measured at four points (top, bottom, left, and right) using an imaging device, and the average value was calculated to obtain membrane thicknesses of 80 μm, 100 μm, and 120 μm, respectively.

[0070] 2) Preparation of filler

[0071] The filler was prepared by mixing 82% by weight of microcrystalline cellulose (MCC), 10% by weight of guar gum, and 8% by weight of water at room temperature, based on 100% of the filler weight. The water activity (Ap) of the filler was measured to be 0.72 using a Shibata water activity meter (HX204).

[0072] 3) Preparation of oral products

[0073] One capsule each of the membranes prepared in step 1) with thicknesses of 80 μm, 100 μm, and 120 μm was added to the filler prepared in step 2), making the total weight of the filler and one capsule 400 mg. The total weight of the filler and one capsule was then placed into a non-woven bag (28 mm × 15 mm) to prepare an oral product with As / Ap = 0.89.

[0074] A simulated human oral dissolution test was conducted, and the menthol release curves of the prepared oral products were tested using gas chromatography-mass spectrometry (GC-MS). Figure 2 As shown. Figure 2 In the figure, release 1 represents the release curve of a capsule with a membrane thickness of 80 μm; release 2 represents the release curve of a capsule with a membrane thickness of 100 μm; and release 3 represents the release curve of a capsule with a membrane thickness of 120 μm.

[0075] Example 3

[0076] 1) Preparation of capsules with different membrane thicknesses

[0077] Based on 100% by weight of the gelatin solution used to prepare the film, 10% by weight of gelatin, 1% by weight of carrageenan, 2% by weight of gellan gum, 10% by weight of glycerin, and 78% by weight of water were mixed at room temperature to form the film gelatin solution. Based on 100% by weight of the core solution, 95% by weight of MCT and 5% by weight of menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film gelatin solution and core solution at different weight ratios of 1, 1.2, and 1.4, respectively, and then at 25°C. o C±2 o C. The capsules were dried at an ambient humidity of 35%±5% RH until the water activity (As) of the capsule membrane was measured to be 0.55 using a Shibata water activity meter (HX204), resulting in capsules with a diameter of 3.5 mm. The membrane thickness of the capsules was measured at four points (top, bottom, left, and right) using an imaging device, and the average value was calculated to obtain membrane thicknesses of 80 μm, 100 μm, and 120 μm, respectively.

[0078] 2) Preparation of filler

[0079] The filler was prepared by mixing 80% by weight of microcrystalline cellulose (MCC), 10% by weight of guar gum, and 10% by weight of water at room temperature, based on 100% of the filler weight. The water activity (Ap) of the filler was measured to be 0.85 using a Shibata water activity meter (HX204).

[0080] 3) Preparation of oral products

[0081] One capsule each of the membranes prepared in step 1) with thicknesses of 80 μm, 100 μm, and 120 μm was added to the filler prepared in step 2), making the total weight of the filler and one capsule 400 mg. The total weight of the filler and one capsule was then placed into a non-woven bag (28 mm × 15 mm) to prepare an oral product with As / Ap = 0.65.

[0082] A simulated human oral dissolution test was conducted, and the menthol release curves of the prepared oral products were tested using gas chromatography-mass spectrometry (GC-MS). Figure 3 As shown. Figure 3 In the figure, release 1 represents the release curve of a capsule with a membrane thickness of 80 μm; release 2 represents the release curve of a capsule with a membrane thickness of 100 μm; and release 3 represents the release curve of a capsule with a membrane thickness of 120 μm.

[0083] from Figure 1-3It can be seen that when the ratio of the water activity of the membrane to the water activity of the filler is greater than 0.50 and less than 0.90, and the membrane thickness is between 80 μm and 120 μm, the oral product is released from the capsule 5 to 15 minutes after entering the oral cavity. Specifically, capsules with a membrane thickness of 80 μm are released 5 minutes after entering the oral cavity; capsules with a membrane thickness of 100 μm are released 10 minutes after entering the oral cavity; and capsules with a membrane thickness of 120 μm are released 15 minutes after entering the oral cavity. Furthermore, from... Figure 1-3 It can also be seen that the release time of the capsule after oral administration of the product is unrelated to the specific composition of the membrane.

[0084] Example 4

[0085] 1) Preparation of capsules with different membrane thicknesses

[0086] Based on 100% by weight of the gelatin solution used to prepare the film, 15% by weight of gelatin, 1% by weight of carrageenan, 2% by weight of gellan gum, 10% by weight of glycerin, and 72% by weight of water were mixed at room temperature to form the film gelatin solution. Based on 100% by weight of the core solution, 95% by weight of MCT and 5% by weight of menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film gelatin solution and core solution at different weight ratios of 0.8, 1, and 1.6, respectively, and then at 25°C. o C±2 o C. The capsules were dried at an ambient humidity of 35%±5% RH until the water activity (As) of the capsule membrane was measured to be 0.53 using a Shibata water activity meter (HX204), resulting in capsules with a diameter of 3.5 mm. The membrane thickness of the capsules was obtained by measuring the thickness at four points (top, bottom, left, and right) using an imaging device and calculating the average value. The thicknesses were 50 μm, 80 μm, and 150 μm, respectively.

[0087] 2) Preparation of filler

[0088] The filler was prepared by mixing 92% by weight of microcrystalline cellulose (MCC), 2% by weight of guar gum, and 6% by weight of water at room temperature, based on 100% of the filler weight. The water activity (Ap) of the filler was measured to be 0.60 using a Shibata water activity meter (HX204).

[0089] 3) Preparation of oral products

[0090] One capsule each of the membranes prepared in step 1) with thicknesses of 50 μm, 80 μm, and 150 μm were added to the filler prepared in step 2), making the total weight of the filler and one capsule 400 mg. The total weight of the filler and one capsule was then placed into a non-woven bag (28 mm × 15 mm) to prepare an oral product with As / Ap = 0.88.

[0091] Example 5

[0092] 1) Preparation of capsules with different membrane thicknesses

[0093] Based on 100% by weight of the gelatin solution used to prepare the film, 15% by weight of gelatin, 1% by weight of carrageenan, 2% by weight of gellan gum, 10% by weight of glycerin, and 72% by weight of water were mixed at room temperature to form the film gelatin solution. Based on 100% by weight of the core solution, 95% by weight of MCT and 5% by weight of menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film gelatin solution and core solution at different weight ratios of 0.8, 1, and 1.6, respectively, and then at 25°C. o C±2 o C. The capsules were dried at an ambient humidity of 35%±5% RH until the water activity (As) of the capsule membrane was measured to be 0.53 using a Shibata water activity meter (HX204), resulting in capsules with a diameter of 3.5 mm. The membrane thickness of the capsules was obtained by measuring the thickness at four points (top, bottom, left, and right) using an imaging device and calculating the average value. The thicknesses were 50 μm, 80 μm, and 150 μm, respectively.

[0094] 2) Preparation of filler

[0095] The filler was prepared by mixing 60 wt% microcrystalline cellulose (MCC), 10 wt% guar gum, and 30 wt% water at room temperature, based on 100% of the filler weight. The water activity (Ap) of the filler was measured to be 0.90 using a Shibata water activity meter (HX204).

[0096] 3) Preparation of oral products

[0097] One capsule each of the membranes prepared in step 1) with thicknesses of 50 μm, 80 μm, and 150 μm were added to the filler prepared in step 2), making the total weight of the filler and one capsule 400 mg. The total weight of the filler and one capsule was then placed into a non-woven bag (28 mm × 15 mm) to prepare an oral product with As / Ap = 0.59.

[0098] Example 6

[0099] 1) Preparation of capsules with different membrane thicknesses

[0100] Based on 100% by weight of the gelatin solution used to prepare the film, 15% by weight of gelatin, 1% by weight of carrageenan, 2% by weight of gellan gum, 10% by weight of glycerin, and 72% by weight of water were mixed at room temperature to form the film gelatin solution. Based on 100% by weight of the core solution, 95% by weight of MCT and 5% by weight of menthol were mixed at room temperature to form the core solution. Capsules were prepared by drop preparation from the above film gelatin solution and core solution at different weight ratios of 0.8, 1, and 1.6, respectively, and then at 25°C. oC ± 2 o C. The capsules were dried in an environment with a humidity of 35% ± 5% RH until the water activity (As) of these capsule membranes measured by a Shibata water activity meter (HX204) was 0.53, and capsules with a diameter of 3.5 mm were obtained. Four points, namely the top, bottom, left, and right of the capsules, were measured by an imager and the average value was calculated to obtain the membrane thicknesses of the aforementioned capsules as 50 μm, 80 μm, and 150 μm respectively.

[0101] 2) Preparation of the filling

[0102] Based on the filling weight being 100%, 45% by weight of microcrystalline cellulose MCC, 15% by weight of guar gum, and 40% by weight of water were mixed at room temperature to prepare the filling. The water activity (Ap) of the filling measured by a Shibata water activity meter (HX204) was 0.95.

[0103] 3) Preparation of the buccal product

[0104] One capsule each with a membrane thickness of 50 μm, 80 μm, and 150 μm prepared in 1) was respectively added to the filling prepared in 2), such that the total weight of the filling and one capsule was 400 mg. The filling with a total weight of 400 mg and one capsule were respectively packed into non-woven bags (28 mm × 15 mm) to prepare a buccal product with As / Ap = 0.56.

[0105] Twenty bags of the buccal products prepared in Examples 4 - 6 were respectively taken and placed in sealed PET boxes, and stored at room temperature for 1, 2, and 3 months to observe for leakage. The results are shown in Table 1 below.

[0106] Table 1

[0107]

[0108] As can be seen from Table 1 above, when the water activity of the capsule membrane (As) < the water activity of the filling (Ap), and 0.50 < As / Ap < 0.90, the capsules with a membrane thickness of 80 μm and 150 μm can be stably stored for 3 months without penetration in fillings with different water contents, especially in the fillings of Examples 5 and 6 with relatively high water contents. The capsules with a membrane thickness of 50 μm only had no leakage in the filling of Example 4 with relatively low water content, and had leakage in the fillings of Examples 5 and 6, which is related to its relatively small membrane thickness. Therefore, in the present invention, while controlling the water activity, the membrane thickness of the capsule is controlled to be between 80 μm and 120 μm, which can achieve the delayed release of the capsule and ensure the storage stability of the buccal product.

[0109] The various specific embodiments described above and shown in the accompanying drawings are for illustrative purposes only and do not represent the entirety of the invention. Any modifications made by those skilled in the art within the scope of the basic technical concept of this invention are within the protection scope of this invention.

Claims

1. A mouth-held product comprising a capsule and a filler surrounding the capsule, the capsule comprising a core liquid and a membrane covering the core liquid, characterized in that, The ratio of the water activity of the membrane to the water activity of the filler is greater than 0.50 and less than 0.90, and the thickness of the membrane is 80 μm to 120 μm.

2. The oral product according to claim 1, characterized in that, The water activity of the membrane is 0.2 to 0.

9.

3. The oral product according to claim 2, characterized in that, The water activity of the membrane is 0.3 to 0.

8.

4. The oral product according to claim 3, characterized in that, The water activity of the membrane is 0.5 to 0.

7.

5. The oral product according to claim 1, characterized in that, The water activity of the filler is 0.6 to 0.

99.

6. The oral product according to claim 1, characterized in that, The film contains colloidal substances and a curing agent.

7. The oral product according to claim 1, characterized in that, The filler comprises one or more of microcrystalline cellulose, plant fiber or starch derivative and water.

8. The oral product according to claim 1, characterized in that, The oral product comprises multiple capsules, and the membrane thickness of the multiple capsules is not exactly the same.

9. The oral product according to claim 1, characterized in that, The core liquid contains flavoring agents and / or active ingredients.

10. The oral product according to claim 9, characterized in that, The oral product comprises multiple capsules, the core liquid of which contains the same or different flavorings and / or active ingredients.

11. The oral product according to claim 1, characterized in that, The oral product is a mouth bag.

12. The oral product according to claim 1, characterized in that, The capsule is released 5 to 15 minutes after the oral product is ingested.

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