Chloride ion detection device for pharmaceutical production

Abstract

The invention relates to the technical field of medicine detection equipment, in particular to a chloride ion detection device for medicine production, which comprises a detection box and a mixing tank fixed at the top end of the detection box, a filter plate is fixed at the bottom end of the mixing tank, a rotating shaft driven by a motor is rotatably arranged in the mixing tank, and an adding mechanism is arranged above the mixing tank. The adding mechanism comprises a reagent box A and a reagent box B which are communicated with the top end of the mixing tank, and a rotating disc rotates at the top end of the mixing tank through a one-way bearing. The position of a cam is switched by adjusting the rotating speed of a motor, so that orderly and uniform adding of a dilute nitric acid solution and a buffer solution is completed, and manual reagent adding is not needed; compared with the prior art, manual operation intensity is reduced, the problems of reagent dosage deviation, non-uniform addition and the like in the manual addition process are avoided, interference factors are effectively eliminated through the synergistic effect of acidification impurity removal and buffer adjustment, a reaction system is stabilized, and the drug chloride ion detection precision is improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical testing equipment technology, and in particular to a chloride ion detection device for pharmaceutical production. Background Technology

[0002] In the pharmaceutical manufacturing process, chloride ions are a common impurity, and their content directly affects the purity, stability, and safety of the drug. Especially for drugs that directly affect the human body, such as injections and oral preparations, excessive chloride ions may cause adverse reactions. Therefore, chloride ion detection is an indispensable quality control link in the pharmaceutical manufacturing process.

[0003] In existing detection devices, auxiliary reagents such as dilute nitric acid and buffer solution are usually added manually to the sample during the detection process to achieve acidification and impurity removal and adjust the pH of the reaction system. However, manual addition is not only labor-intensive, but also prone to reagent dosage deviation and uneven addition, which leads to instability of the reaction system, inability to fully remove interfering ions, and thus affects the accuracy of chloride ion detection and increases detection error.

[0004] In view of this, we have studied and improved the existing problems to provide a chloride ion detection device for pharmaceutical production. The aim of this technology is to solve the problems and improve its practical value. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the existing technology and to propose a chloride ion detection device for pharmaceutical production.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a chloride ion detection device for pharmaceutical production, comprising a detection box and a mixing tank fixed to the top of the detection box, wherein a filter plate is fixed to the bottom of the mixing tank, and a rotating shaft driven by a motor is rotatable inside the mixing tank; The mixing tank is equipped with an addition mechanism above it. The addition mechanism includes a reagent tank A and a reagent tank B connected to the top of the mixing tank. A turntable is rotatable at the top of the mixing tank via a one-way bearing and is fixedly sleeved on a rotating shaft. A sliding groove is provided on the turntable, and a slider slides inside the groove. A centrifugal ball is fixed outside the slider. The slider is hinged to a cam via a rotating rod. The cam is slidably sleeved on the rotating shaft. The tops of reagent tank A and reagent tank B are respectively connected to L-shaped tube A and L-shaped tube B. Extrusion rod A and extrusion rod B slide inside L-shaped tube A and L-shaped tube B respectively. The cam intermittently contacts and engages with extrusion rod A and extrusion rod B when it is in different positions. The outer wall of the rotating shaft is provided with a mixing mechanism, which includes a magnetic ring that slides on the outer wall of the rotating shaft. Multiple sets of equally spaced stirring blades are fixed on the outer wall of the magnetic ring. The outer wall of the rotating shaft is provided with a reciprocating thread. A magnetic cylinder is threadedly connected to the outer wall of the rotating shaft. Multiple sets of equally spaced flipping plates are rotatably provided on the outer wall of the magnetic cylinder. The stirring blades and flipping plates are arranged in an alternating manner. A closing mechanism is provided at the bottom of the mixing tank.

[0007] Preferably, both medicine tank A and medicine tank B are provided with a liquid outlet pipe at their bottom, and the liquid outlet pipe is inclined.

[0008] Preferably, a first spring is provided inside the slide groove, one end of the first spring is fixedly connected to the slider, and the other end of the first spring is fixedly connected to the inner wall of the slide groove. A second spring is sleeved on the outer wall of both the extrusion rod A and the extrusion rod B.

[0009] Preferably, the mixing mechanism further includes piercing needles and a sealing plate. The surface of the flipping plate is provided with a plurality of piercing needles, and the sealing plate is correspondingly installed at one end of the flipping plate. A limiting groove is opened on the outer wall of the rotating shaft. The magnetic ring slides along the axial direction of the limiting groove. The flipping plate can rotate relative to the magnetic cylinder, and after the flipping plate rotates, it can fit with the stirring plate to form a combined sealing structure.

[0010] Preferably, the closing mechanism includes a bidirectional cylinder installed on the side wall of the mixing tank, and the telescopic end of the bidirectional cylinder is fixed with two sets of closing plates, which cover the bottom opening of the mixing tank and cooperate with the filter plate.

[0011] Preferably: the telescopic end of the bidirectional cylinder is fitted with a connecting block; a liquid storage pipe runs through the interior of the mixing tank; the liquid storage pipe is filled with hydraulic oil; a push rod slides inside the liquid storage pipe; one end of the push rod is fixedly connected to the connecting block; the other end extends into the liquid storage pipe and slides and seals with the liquid storage pipe; the liquid storage pipe is connected to the inner cavity of the rotating shaft through connecting pipe A; a magnetic block is slidably connected to the inner cavity of the rotating shaft; the magnetic block and the magnetic ring are magnetically attracted; a rack is fixed to the top of the magnetic block; and a gear that meshes with the rack is fixed to one end of the flipping plate.

[0012] Preferably, a third spring is provided inside the rotating shaft, one end of which abuts against the bottom end of the magnet and the other end abuts against the inner wall of the rotating shaft.

[0013] Preferably, the outer wall of the liquid storage tube is connected to a connecting pipe B, and one end of the connecting pipe B that extends into the mixing tank is connected to a vertical pipe. A limit rod slides inside the vertical pipe. The limit rod is used to limit the rotation trajectory of the flip plate and the stirring plate after they are combined. The surface of the magnetic cylinder is provided with an insertion hole that matches the limit rod. A fourth spring is sleeved on the outer wall of the limit rod.

[0014] Preferably, the mixing tank is equipped with a feeding port at its top, and the detection box is equipped with a detection head, which is electrically connected to an external detector via a wire.

[0015] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention achieves the switching of cam position by adjusting the motor speed, thereby completing the orderly and uniform addition of dilute nitric acid solution and buffer solution. There is no need for manual addition of reagents, which not only reduces the intensity of manual operation, but also avoids problems such as reagent dosage deviation and uneven addition during manual addition. At the same time, through the synergistic effect of acidification and buffer adjustment, interference factors are effectively eliminated, the reaction system is stabilized, and the accuracy of chloride ion detection in pharmaceuticals is improved.

[0016] 2. This invention uses a motor to drive a high-speed rotating shaft, which in turn drives a stirring plate. Dilute nitric acid solution from reagent tank A is intermittently added as the shaft and turntable rotate. Under the action of the high-speed stirring plate, the solution fully mixes with the substances in the tank, increasing the contact area, improving chloride ion dissolution efficiency, and accelerating its precipitation. When switching to the buffer solution addition stage, the motor is adjusted to a low speed, and the shaft drives the stirring plate to gently stir, ensuring uniform contact between the buffer solution and the mixed system. This avoids localized accumulation that could lead to uneven pH levels, ensuring the buffer solution adjustment effect and detection stability, while also preventing the generation of additional bubbles. Furthermore, any surface bubbles generated during the reaction process are promptly punctured by the piercing needles on the rotating plate surface, which is driven to rotate synchronously by the shaft, preventing bubbles from hindering mixing and reaction. This indirectly ensures chloride ion dissolution efficiency and reaction sufficiency, improving detection consistency.

[0017] 3. This invention utilizes the combined flip plate and stirring blade to move up and down along the reciprocating threads on the outer wall of the rotating shaft. This movement generates a slight negative pressure inside the mixing tank. This slight negative pressure creates downward pressure on the solution inside the mixing tank, thereby accelerating the filtration rate of the solution through the filter plate, effectively shortening the filtration time, reducing the overall time consumption of the chloride ion detection process, and thus improving the overall detection efficiency. At the same time, the filtered solution is purer, improving the accuracy of subsequent detection. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is one of the partial structural schematic diagrams of the present invention; Figure 3 For the present invention Figure 2 Enlarged structural diagram of section A; Figure 4 This is one of the cross-sectional structural diagrams of the mixing tank of the present invention; Figure 5 This is a schematic diagram of the unfolded structure of the stirring plate and the tilting plate of the present invention; Figure 6 This is a second schematic cross-sectional view of the mixing tank of the present invention; Figure 7 For the present invention Figure 6 Enlarged structural diagram of section B; Figure 8 This is a partial structural schematic diagram of the present invention; Figure 9 This is a cross-sectional structural diagram of the detection box of the present invention.

[0019] Legend: 1. Detection box; 2. Mixing tank; 3. Motor; 4. Rotating shaft; 51. Reagent tank A; 52. Reagent tank B; 53. Turntable; 54. Cam; 55. Slide groove; 56. Slider; 57. Rotating rod; 58. L-shaped tube A; 59. Extrusion rod A; 510. L-shaped tube B; 511. Extrusion rod B; 512. Discharge pipe; 513. Centrifugal ball; 61. Magnetic ring; 62. Stirring blade; 63. Magnetic cylinder; 64. Tilting plate; 65. Piercing needle; 66. Sealing plate; 71. Closing plate; 72. Two-way cylinder; 73. Storage pipe; 74. Connecting block; 75. Push rod; 76. Connecting pipe A; 77. Magnetic block; 78. Connecting pipe B; 79. Vertical pipe; 710. Limiting rod; 711. Gear; 712. Rack; 8. Filter plate; 9. Detection head; 10. Feed port. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0021] See Figures 1 to 9 As shown, the present invention provides a chloride ion detection device for pharmaceutical production, including a detection box 1 and a mixing tank 2 fixed to the top of the detection box 1. A filter plate 8 is fixed to the bottom of the mixing tank 2, and a rotating shaft 4 driven by a motor 3 rotates inside the mixing tank 2. An adding mechanism is provided above the mixing tank 2. The adding mechanism includes a reagent tank A51 and a reagent tank B52 connected to the top of the mixing tank 2. A turntable 53 is rotatable at the top of the mixing tank 2 via a one-way bearing. The turntable 53 is fixedly sleeved on the rotating shaft 4. A sliding groove 55 is provided on the turntable 53. A slider 56 slides inside the sliding groove 55. A centrifugal ball 513 is fixed outside the slider 56. The slider 56 is hinged to a cam 54 via a rotating rod 57. The cam 54 is slidably sleeved on the rotating shaft 4. The tops of the reagent tanks A51 and B52 are respectively connected to L-shaped tubes A58 and B510. An extrusion rod A59 and an extrusion rod B511 slide inside the L-shaped tubes A58 and B510 respectively. When the cam 54 is in different positions, it intermittently contacts and cooperates with the extrusion rods A59 and B511 respectively. It should be noted that: First, the medicine powder is added into the mixing tank 2 through the feeding port 10, and a certain proportion of chloride-free purified water is added into the mixing tank 2 as a solvent. Then, the motor 3 is started in reverse. At this time, the motor 3 drives the rotating shaft 4 to rotate synchronously at high speed. When the rotating shaft 4 rotates, it will drive the turntable 53 to rotate together. During the rotation of the turntable 53, the slider 56 in the inner groove 55 will drive the centrifugal ball 513 on the outside to generate centrifugal force. Under the action of centrifugal force, the centrifugal ball 513 moves to the outside of the turntable 53, which in turn drives the slider 56 to slide along the inside of the groove 55 to the outside of the turntable 53. When the slider 56 slides, it pulls the cam 54 along the rotating shaft 4 through the rotating rod 57. The axis moves downwards. When the cam 54 moves to a specific distance, it will be on the same horizontal line as the extrusion rod A59. At this time, as the turntable 53 and the rotating shaft 4 continue to rotate, the cam 54 will form an intermittent contact with the extrusion rod A59. The rotation of the cam 54 pushes the extrusion rod A59 to slide inside the L-shaped tube A58, thereby extruding the inside of the reagent tank A51. This causes the dilute nitric acid solution stored in the reagent tank A51 to be uniformly extruded and added into the mixing tank 2. The addition of the dilute nitric acid solution can achieve acidification, effectively eliminating interfering ions such as carbonate, bicarbonate, sulfate, and sulfite in the drug sample, and avoiding these interfering ions from affecting the accuracy of subsequent chloride ion detection. After the dilute nitric acid solution has been added for a period of time and the preset acidification effect has been achieved, the control motor 3 switches to a low-speed rotation state. At this time, the rotation speed of the rotating shaft 4 decreases, and the centrifugal force generated by the rotation of the turntable 53 also decreases. Under the elastic reset action of the first spring inside the slide groove 55, the slider 56 moves towards the inner side of the turntable 53. When the slider 56 moves, it drives the cam 54 to move upward along the axis of the rotating shaft 4 through the rotating rod 57 until the cam 54 and the extrusion rod B511 are at the same horizontal line. Subsequently, as the rotating shaft 4 continues to rotate at a low speed, the cam 54 and the extrusion rod B511 form an intermittent contact engagement, pushing the extrusion rod B511 to slide inside the L-shaped tube B510, thereby... Squeezing reagent tank B52 evenly adds the buffer solution stored inside to mixing tank 2. The buffer solution adjusts the pH of the mixture in mixing tank 2, keeping the system within the appropriate pH range for chloride ion detection. The position of cam 54 is switched by adjusting the speed of motor 3, thus completing the orderly and uniform addition of dilute nitric acid solution and buffer solution. This eliminates the need for manual reagent addition, reducing the intensity of manual operation and avoiding problems such as reagent dosage deviation and uneven addition during manual addition. At the same time, through the synergistic effect of acidification and buffer adjustment, interference factors are effectively eliminated, the reaction system is stabilized, and the accuracy of chloride ion detection is improved.

[0022] The outer wall of the rotating shaft 4 is provided with a mixing mechanism, which includes a magnetic ring 61 that slides on the outer wall of the rotating shaft 4. Multiple sets of equally spaced stirring blades 62 are fixed on the outer wall of the magnetic ring 61. The outer wall of the rotating shaft 4 is provided with a reciprocating thread. A magnetic cylinder 63 is threadedly connected to the outer wall of the rotating shaft 4. Multiple sets of equally spaced flipping plates 64 are rotatably provided on the outer wall of the magnetic cylinder 63. The stirring blades 62 and the flipping plates 64 are arranged in an alternating manner. A closing mechanism is provided at the bottom of the mixing tank 2.

[0023] In an optional embodiment, both reagent tanks A51 and B52 are provided with a corresponding outlet pipe 512 at the bottom. The outlet pipe 512 is inclined, which can prevent reagents from flowing and remaining along the inner wall of the mixing tank 2, ensuring accurate reagent dosage and reducing detection errors.

[0024] In an optional embodiment, a first spring is provided inside the slide 55. One end of the first spring is fixedly connected to the slider 56, and the other end of the first spring is fixedly connected to the inner wall of the slide 55. A second spring is sleeved on the outer wall of both the extrusion rod A59 and the extrusion rod B511.

[0025] In an optional embodiment, the mixing mechanism includes piercing needles 65 and sealing plate 66. The surface of the flip plate 64 is provided with a plurality of piercing needles 65, and the sealing plate 66 is correspondingly installed at one end of the flip plate 64. A limiting groove is opened on the outer wall of the rotating shaft 4. The magnetic ring 61 slides along the axial direction of the limiting groove. The flip plate 64 can rotate relative to the magnetic cylinder 63, and after the flip plate 64 rotates, it can fit with the stirring plate 62 to form a combined sealing structure.

[0026] It should be noted that: after adding the drug powder and chloride-free purified water into the mixing tank 2 in the early stage of testing, and starting the motor 3 to drive the rotating shaft 4 to rotate at high speed, when the dilute nitric acid solution is intermittently added into the mixing tank 2 from the reagent tank A51, the rotating shaft 4 will simultaneously drive the stirring plate 62 to rotate. The stirring plate 62 will then continuously stir the dilute nitric acid solution added into the mixing tank 2. Since the motor 3 is rotating at high speed, the rotating shaft 4 drives the stirring plate 62 to maintain high speed rotation, and the dilute nitric acid solution in the reagent tank A51 will be intermittently added into the mixing tank 2 along with the rotation of the rotating shaft 4 and the turntable 53. Under the continuous stirring action of the stirring plate 62, the newly added dilute nitric acid solution can quickly and fully contact and uniformly mix with the drug powder and chloride-free purified water already in the mixing tank 2, effectively increasing the contact area between the dilute nitric acid solution and the drug powder, thereby improving the dissolution efficiency of the solution for chloride ions inside the drug powder and accelerating the precipitation of chloride ions in the drug powder. When the detection process switches to the stage of adding buffer solution, the control motor 3 is adjusted to a low-speed rotation state, and the rotating shaft 4 rotates at a low speed and drives the stirring plate 62 to perform slight stirring in sync. The slight stirring can promote the full integration of the buffer solution with the drug powder, chloride-free purified water and the pre-acidified mixture in the mixing tank 2, avoid local accumulation of buffer solution which would lead to uneven pH distribution in the mixture, and ensure that the buffer solution can fully play its role in regulating the pH of the system, so that the mixture is always within the appropriate pH range required for chloride ion detection, further ensuring the stability of the subsequent detection reaction and the reliability of the detection results, while preventing the generation of additional bubbles due to excessive stirring. Furthermore, during the reaction of dilute nitric acid solution with the mixed system, the dilute nitric acid reacts with impurity ions in the drug sample to produce gases such as carbon dioxide. When buffer solution is added to adjust the pH, the buffer solution further reacts with residual reaction intermediates or unreacted substances in the system, which also releases a small amount of gas. These gases escape from the liquid surface and form bubbles. During the rotation of the rotating shaft 4, the flip plate 64 rotates synchronously. The piercing needles 65 on the surface of the flip plate 64 act synchronously with the rotation of the flip plate 64 to pierce the floating bubbles in time, preventing bubbles from hindering the full contact of various substances in the mixed system. This prevents problems such as insufficient mixing and incomplete reaction caused by the presence of bubbles, indirectly ensuring the chloride ion dissolution efficiency and the sufficiency of the detection reaction, and improving the consistency and stability of the entire detection process.

[0027] In an optional embodiment, the closing mechanism includes a bidirectional cylinder 72 installed on the side wall of the mixing tank 2. The telescopic end of the bidirectional cylinder 72 is fixed with two sets of closing plates 71, which cover the bottom opening of the mixing tank 2 and cooperate with the filter plate 8.

[0028] In an optional embodiment, a connecting block 74 is fitted onto the telescopic end of the bidirectional cylinder 72. A liquid storage pipe 73 runs through the interior of the mixing tank 2. The liquid storage pipe 73 is filled with hydraulic oil. A push rod 75 slides inside the liquid storage pipe 73. One end of the push rod 75 is fixedly connected to the connecting block 74, and the other end extends into the interior of the liquid storage pipe 73 and slides and seals with the liquid storage pipe 73. The liquid storage pipe 73 is connected to the inner cavity of the rotating shaft 4 through the connecting pipe A76. A magnetic block 77 is slidably connected to the inner cavity of the rotating shaft 4. The magnetic block 77 is magnetically attracted to the magnetic ring 61. A rack 712 is fixed to the top of the magnetic block 77. A gear 711 that meshes with the rack 712 is fixed to one end of the flip plate 64.

[0029] In an optional embodiment, a third spring is provided inside the rotating shaft 4. One end of the third spring abuts against the bottom end of the magnetic block 77, and the other end abuts against the inner wall of the rotating shaft 4. After the filtration stage is completed, the bidirectional cylinder 72 is reset, the hydraulic oil pressure in the liquid storage tube 73 is released, and the third spring can push the magnetic block 77 to reset downward, thereby driving the magnetic ring 61, the stirring plate 62 and the rack 712 to reset synchronously, so that the flip plate 64 is disengaged from the contact state with the stirring plate 62 and returns to the initial position.

[0030] In an optional embodiment, the outer wall of the liquid storage pipe 73 is connected to a connecting pipe B78, and one end of the connecting pipe B78 that extends into the mixing tank 2 is connected to a vertical pipe 79. A limit rod 710 slides inside the vertical pipe 79. The limit rod 710 is used to limit the rotation trajectory of the flip plate 64 and the stirring plate 62 after they are combined. The surface of the magnetic cylinder 63 is provided with an insertion hole that matches the limit rod 710. A fourth spring is sleeved on the outer wall of the limit rod 710.

[0031] It should be noted that: after the reaction in the mixing tank 2 is completed, the bidirectional cylinder 72 is activated. The extension and retraction end of the bidirectional cylinder 72 will drive the two sets of closing plates 71 to move away from each other. The closing plates 71 that originally covered the bottom opening of the mixing tank 2 are no longer sealed, so that the solution after the reaction inside the mixing tank 2 can pass smoothly through the filter plate 8 for filtration. The filter plate 8 can effectively remove undissolved drug powder impurities in the solution and prevent impurities from entering the subsequent detection process and affecting the accuracy of chloride ion detection. During the movement of the closing plate 71, the bidirectional cylinder 72 synchronously drives the connecting block 74 to move. The connecting block 74 then drives the push rod 75 to move synchronously. The push rod 75 slides into the reservoir 73 and squeezes the hydraulic oil stored in the reservoir 73, causing the hydraulic oil in the reservoir 73 to be divided into two parts for delivery. One part of the hydraulic oil enters the inner cavity of the rotating shaft 4 through the connecting pipe A76. The hydraulic oil entering the inner cavity of the rotating shaft 4 exerts an upward squeezing force on the magnetic block 77, pushing the magnetic block 77 to move upward along the internal axis of the rotating shaft 4. Due to the magnetic attraction between the magnetic block 77 and the magnetic ring 61, when the magnetic block 77 moves upward, it will synchronously drive the magnetic ring 61 and the stirring plate 62 fixed on the outer wall of the magnetic ring 61 to move upward together. At the same time, the rack 712 fixed at the top of the magnetic block 77 will also move upward synchronously with the magnetic block 77. When the rack 712 moves to a specific position, it will mesh with the gear 711 fixed at one end of the flip plate 64. As the magnetic block 77 continues to drive the rack 712 upward, the rack 712 drives the gear 711 to rotate. The gear 711 then drives the flip plate 64 to rotate 90 degrees synchronously, changing the flip plate 64 from its original vertical state to a flat state. When the magnetic ring 61 and the magnetic cylinder 63 are in contact with each other, they attract each other. At this time, the flat flip plate 64 and the upward-moving stirring plate 62 are in contact with each other, forming a combined sealing structure. At the same time, another part of the hydraulic oil in the liquid storage pipe 73 enters the interior of the vertical pipe 79 through the connecting pipe B78. The hydraulic oil exerts a downward thrust on the limiting rod 710 in the vertical pipe 79, pushing the limiting rod 710 to slide downward along the interior of the vertical pipe 79 until the bottom end of the limiting rod 710 is inserted into the pre-set insertion hole on the surface of the magnetic cylinder 63, thus limiting and fixing the combined flip plate 64 and the stirring plate 62 to prevent relative displacement or separation during subsequent rotation. In summary, after the tilting plate 64 and the stirring plate 62 are fitted together to form a combined sealed structure, the motor 3 is controlled to rotate forward. The motor 3 drives the rotating shaft 4 to rotate forward synchronously. Since the limiting rod 710 limits the magnetic cylinder 63 and the combined tilting plate 64 and stirring plate 62, they cannot rotate synchronously with the rotating shaft 4. The outer wall of the rotating shaft 4 is provided with reciprocating threads. During the rotation of the rotating shaft 4, the combined tilting plate 64 and stirring plate 62 will move up and down along the reciprocating threads on the outer wall of the rotating shaft 4. This movement process will generate a slight negative pressure inside the mixing tank 2. The slight negative pressure generated can form a downward pressure on the solution in the mixing tank 2, thereby accelerating the filtration rate of the solution through the filter plate 8, effectively shortening the filtration time, reducing the time consumed in the entire chloride ion detection process, thereby improving the overall detection efficiency. At the same time, the filtered solution is purer, improving the accuracy of subsequent detection.

[0032] In an optional embodiment, a feed port 10 is installed at the top of the mixing tank 2, and a detection head 9 is installed inside the detection box 1. The detection head 9 is electrically connected to an external detector via a wire. After the solution is filtered, the chloride ions inside the solution can be detected by the detection head 9 and the detector.

[0033] Working principle: First, the medicine powder is fed into the mixing tank 2 through the feeding port 10, and a certain proportion of chloride-free purified water is added into the mixing tank 2 as a solvent. Then, the motor 3 is started to reverse. At this time, the motor 3 drives the rotating shaft 4 to rotate synchronously at high speed. When the rotating shaft 4 rotates, it will drive the turntable 53 to rotate together. During the rotation of the turntable 53, the slider 56 in the inner groove 55 will drive the centrifugal ball 513 on the outside to generate centrifugal force. The centrifugal ball 513 moves to the outside of the turntable 53, which in turn drives the slider 56 to slide along the inside of the groove 55 to the outside of the turntable 53. When the slider 56 slides, it pulls the cam 54 to move downward along the axis of the rotating shaft 4 through the rotating rod 57. When the cam 54 moves to a certain distance, it will be on the same horizontal line as the extrusion rod A59. The cam 54 will form an intermittent contact with the extrusion rod A59, which will then extrude the inside of the medicine tank A51, so that the dilute nitric acid solution stored in the medicine tank A51 is evenly extruded and added into the mixing tank 2. After the dilute nitric acid solution is added for a period of time and the preset acidification effect is achieved, the control motor 3 switches to low-speed rotation. The centrifugal force generated by the rotation of the turntable 53 also decreases. Under the elastic reset action of the first spring inside the slide groove 55, the cam 54 and the extrusion rod B511 are on the same horizontal line. The cam 54 and the extrusion rod B511 form an intermittent contact cooperation, pushing the extrusion rod B511 to slide inside the L-shaped tube B510, thereby extruding the reagent tank B52 and uniformly adding the buffer solution stored inside the reagent tank B52 into the mixing tank 2. The buffer solution can adjust the pH of the mixing system in the mixing tank 2, so that the system is in the appropriate pH range for chloride ion detection. When dilute nitric acid solution is intermittently added from reagent tank A51 into mixing tank 2, the rotating shaft 4 will synchronously drive the stirring plate 62 to rotate. The stirring plate 62 will then continuously stir the dilute nitric acid solution added into mixing tank 2. Under the continuous stirring action of the stirring plate 62, the newly added dilute nitric acid solution can quickly and fully contact and evenly mix with the existing drug powder and chloride-free purified water in mixing tank 2. When the detection process switches to the stage of adding buffer solution, the control motor 3 is adjusted to a low speed rotation state, and the rotating shaft 4 rotates at a low speed and drives the stirring plate 62 to perform slight stirring in sync. The slight stirring can promote the full integration of the buffer solution with the drug powder, chloride-free purified water and the pre-acidified mixture in the mixing tank 2. In addition, the rotating shaft 4 will drive the flip plate 64 to rotate synchronously during the rotation process. The piercing needle 65 set on the surface of the flip plate 64 will act synchronously on the floating bubbles as the flip plate 64 rotates, and pierce the generated bubbles in time. When the reaction in the mixing tank 2 is completed, the bidirectional cylinder 72 is activated. The extension and retraction end of the bidirectional cylinder 72 will drive the two sets of closing plates 71 to move away from each other. The closing plates 71 that originally covered the bottom opening of the mixing tank 2 are released from the sealed state, so that the solution after the reaction inside the mixing tank 2 can be filtered smoothly through the filter plate 8. During the movement of the closing plate 71, the bidirectional cylinder 72 synchronously drives the connecting block 74 to move, which in turn drives the push rod 75 to move synchronously. The push rod 75 slides into the reservoir 73 and squeezes the hydraulic oil stored in the reservoir 73. A portion of the hydraulic oil enters the inner cavity of the rotating shaft 4 through the connecting pipe A76. The hydraulic oil entering the inner cavity of the rotating shaft 4 exerts an upward squeezing force on the magnetic block 77, pushing the magnetic block 77 to move upward along the internal axis of the rotating shaft 4. When the magnetic block 77 moves upward, it synchronously drives the magnetic ring 61 and the stirring plate 62 fixed on the outer wall of the magnetic ring 61 to move upward together. At the same time, the rack 712 fixed at the top of the magnetic block 77 also moves upward synchronously with the magnetic block 77. When the rack 712 moves to a specific position, it meshes with the gear 711 fixed at one end of the flip plate 64. As the magnetic block 77 continues to move upward, the magnetic ring 61 moves upward. The rack 712 continues to move upward, which in turn drives the gear 711 to rotate. The gear 711 then drives the tilting plate 64 to rotate 90 degrees synchronously, changing the tilting plate 64 from its original vertical state to a flat state. At this time, the flat tilting plate 64 and the upward-moving stirring plate 62 fit together to form a combined sealing structure. At the same time, another part of the hydraulic oil in the reservoir pipe 73 enters the interior of the vertical pipe 79 through the connecting pipe B78. The hydraulic oil exerts a downward thrust on the limiting rod 710 in the vertical pipe 79, pushing the limiting rod 710 to slide downward along the interior of the vertical pipe 79 until the bottom end of the limiting rod 710 is inserted into the pre-set insertion hole on the surface of the magnetic cylinder 63, thus limiting and fixing the combined tilting plate 64 and stirring plate 62 to prevent relative displacement or separation during subsequent rotation. When the tilting plate 64 and the stirring plate 62 come into contact with each other to form a combined sealed structure, the motor 3 is controlled to rotate forward. The motor 3 drives the rotating shaft 4 to rotate forward synchronously. During the rotation of the rotating shaft 4, the combined tilting plate 64 and the stirring plate 62 will move up and down along the reciprocating thread on the outer wall of the rotating shaft 4. This movement process will generate a slight negative pressure inside the mixing tank 2. The slight negative pressure generated can exert downward pressure on the solution in the mixing tank 2, thereby accelerating the filtration rate of the solution through the filter plate 8.

[0034] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A chloride ion detection device for pharmaceutical production, comprising a detection chamber (1) and a mixing tank (2) fixed to the top of the detection chamber (1), characterized in that: The bottom of the mixing tank (2) is fixed with a filter plate (8), and the inside of the mixing tank (2) is a rotating shaft (4) driven by a motor (3). The mixing tank (2) is provided with an addition mechanism above it. The addition mechanism includes a reagent tank A (51) and a reagent tank B (52) connected to the top of the mixing tank (2). A turntable (53) is rotatable at the top of the mixing tank (2) via a one-way bearing. The turntable (53) is fixedly sleeved on the rotating shaft (4). A sliding groove (55) is provided on the turntable (53). A slider (56) slides inside the sliding groove (55). A centrifugal ball (513) is fixed outside the slider (56). The slider (56) is connected to the centrifugal ball (513). The rotating rod (57) is hinged to the cam (54), and the cam (54) is slidably sleeved on the rotating shaft (4). The top of the medicine box A (51) and the medicine box B (52) are respectively connected to the L-shaped tube A (58) and the L-shaped tube B (510). The extrusion rod A (59) and the extrusion rod B (511) slide inside the L-shaped tube A (58) and the L-shaped tube B (510), respectively. When the cam (54) is in different positions, it intermittently contacts and cooperates with the extrusion rod A (59) and the extrusion rod B (511). The outer wall of the rotating shaft (4) is provided with a mixing mechanism, which includes a magnetic ring (61) that slides on the outer wall of the rotating shaft (4). The outer wall of the magnetic ring (61) is fixed with multiple sets of equally spaced stirring blades (62). The outer wall of the rotating shaft (4) is provided with a reciprocating thread. The outer wall of the rotating shaft (4) is threadedly connected with a magnetic cylinder (63). The outer wall of the magnetic cylinder (63) is rotatably provided with multiple sets of equally spaced flipping plates (64). The stirring blades (62) and the flipping plates (64) are arranged in an alternating manner. The mixing tank (2) is provided with a closing mechanism at its bottom.

2. The chloride ion detection device for pharmaceutical production according to claim 1, characterized in that: Both medicine boxes A (51) and B (52) are equipped with liquid outlet pipes (512) at their bottoms, and the liquid outlet pipes (512) are inclined.

3. The chloride ion detection device for pharmaceutical production according to claim 1, characterized in that: The slide groove (55) is provided with a first spring inside. One end of the first spring is fixedly connected to the slider (56), and the other end of the first spring is fixedly connected to the inner wall of the slide groove (55). The outer walls of the extrusion rod A (59) and the extrusion rod B (511) are both fitted with second springs.

4. The chloride ion detection device for pharmaceutical production according to claim 1, characterized in that: The mixing mechanism also includes piercing needles (65) and sealing plates (66). The surface of the flip plate (64) is provided with several piercing needles (65). The sealing plate (66) is installed at one end of the flip plate (64). The outer wall of the rotating shaft (4) is provided with a limiting groove. The magnetic ring (61) slides along the axial direction of the limiting groove. The flip plate (64) can rotate relative to the magnetic cylinder (63). After the flip plate (64) rotates, it can fit with the stirring plate (62) to form a combined sealing structure.

5. The chloride ion detection device for pharmaceutical production according to claim 1, characterized in that: The closing mechanism includes a bidirectional cylinder (72) installed on the side wall of the mixing tank (2). The telescopic end of the bidirectional cylinder (72) is fixed with two sets of closing plates (71). The two sets of closing plates (71) cover the bottom opening of the mixing tank (2) and cooperate with the filter plate (8).

6. The chloride ion detection device for pharmaceutical production according to claim 5, characterized in that: The telescopic end of the bidirectional cylinder (72) is fitted with a connecting block (74). The inside of the mixing tank (2) is a liquid storage pipe (73). The liquid storage pipe (73) is filled with hydraulic oil. A push rod (75) slides inside the liquid storage pipe (73). One end of the push rod (75) is fixedly connected to the connecting block (74), and the other end extends into the inside of the liquid storage pipe (73) and slides and seals with the liquid storage pipe (73). The liquid storage pipe (73) is connected to the inner cavity of the rotating shaft (4) through the connecting pipe A (76). A magnetic block (77) is slidably connected to the inner cavity of the rotating shaft (4). The magnetic block (77) is magnetically attracted to the magnetic ring (61). A rack (712) is fixed at the top of the magnetic block (77). A gear (711) that meshes with the rack (712) is fixed at one end of the flip plate (64).

7. A chloride ion detection device for pharmaceutical production according to claim 6, characterized in that: The rotating shaft (4) is equipped with a third spring inside. One end of the third spring abuts against the bottom end of the magnetic block (77), and the other end abuts against the inner wall of the rotating shaft (4).

8. A chloride ion detection device for pharmaceutical production according to claim 6, characterized in that: The outer wall of the liquid storage tube (73) is connected to a connecting tube B (78). One end of the connecting tube B (78) that extends into the mixing tank (2) is connected to a vertical tube (79). A limit rod (710) slides inside the vertical tube (79). The limit rod (710) is used to limit the rotation trajectory of the flip plate (64) and the stirring plate (62) after they are combined. The surface of the magnetic cylinder (63) is provided with an insertion hole that matches the limit rod (710). A fourth spring is sleeved on the outer wall of the limit rod (710).

9. A chloride ion detection device for pharmaceutical production according to claim 1, characterized in that: The mixing tank (2) is equipped with a feeding port (10) at the top, and the detection box (1) is equipped with a detection head (9) inside. The detection head (9) is electrically connected to an external detector through a wire.

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