Microorganism control composition based on cinnamate and application thereof

Abstract

The invention provides a cinnamate-based microbe control composition and application thereof, the cinnamate-based microbe control composition comprises cinnamate and a microbe inhibition synergist according to a set ratio, the cinnamate is selected from one or a combination of sodium cinnamate and potassium cinnamate, and the microbe inhibition synergist is selected from one or a combination of sodium cinnamate and potassium cinnamate. The cinnamate is selected as a brand-new preservative additive component of the daily chemical products to inhibit microorganisms in various daily chemical products, and has the advantages of being environmentally friendly and good in antibacterial effect.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products, and in particular to a microbial control composition based on cinnamate and its application. Background Technology

[0002] Daily chemical products refer to everyday chemical products. These products encompass cosmetics, personal care products, detergents, and toiletries. Specific product types include, but are not limited to, shampoos, conditioners, shower gels, facial cleansers, face creams, cosmetics, and wet wipes. These products aim to cleanse, moisturize, protect, and beautify the skin, hair, mouth, and other parts of the body to maintain personal hygiene, health, and appearance. To achieve these effects, various daily chemical products contain water and nutrients. However, environments rich in water and nutrients are ideal for microbial growth, making it easy for microorganisms to multiply and contaminate these products. Therefore, appropriate amounts of microbial control agents are added to daily chemical products to provide a preservative effect.

[0003] Traditional preservatives pose potential risks to physiological safety and the environment, and have been replaced by safer and more environmentally friendly microbial control agents. Currently available green, environmentally friendly, and mild microbial control agents include, but are not limited to, external preservatives such as p-hydroxyacetophenone, capryloyl hydroxamic acid, caprylyl glycol, ethylhexylglycerin, 1,2-hexanediol, and pentanediol. While these microbial control agents have significantly improved mildness, their corresponding antibacterial effects are not ideal. Therefore, to achieve the desired antibacterial effect, the concentration of these microbial control agents needs to be increased. For example, the MIC of p-hydroxyacetophenone against Escherichia coli, Pseudomonas aeruginosa, and Aspergillus niger is 0.4%, while the MIC against Staphylococcus aureus and Candida albicans is 0.6%. Pentanediol even has a MIC as high as 1.6-2.5% against Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger. It is evident that the antibacterial effect of such mild microbial control agents is insufficient to meet the antibacterial requirements of practical personal care products. Therefore, there is an urgent need for a new type of microbial control agent for personal care products that combines green mildness with antibacterial effect. Summary of the Invention

[0004] The purpose of this invention is to provide a microbial control composition based on cinnamate and its application. Cinnamate is selected as a novel additive for daily chemical products to inhibit microorganisms in daily chemical products, which has the advantages of being green and environmentally friendly and having a good antibacterial effect.

[0005] To achieve the above objectives, this solution provides a microbial control composition based on cinnamate, comprising: a predetermined ratio of cinnamate and a microbial inhibitory synergist, wherein the cinnamate is selected from sodium cinnamate and potassium cinnamate or a combination thereof.

[0006] It should be noted that this solution innovatively uses cinnamate as a microbial control ingredient in daily chemical products, and synergistically combines cinnamate with other microbial inhibitors to provide excellent antibacterial effects while being environmentally friendly. Cinnamate is a novel additive in the context of daily chemical products, and its water solubility is significantly improved compared to cinnamic acid. In particular, the water solubility of potassium cinnamate is over 15% (the solubility of cinnamic acid is about 0.12%), which means that the addition of potassium cinnamate is well compatible with other ingredients in daily chemical products. At the same time, after being absorbed by the human body, cinnamate (potassium cinnamate and sodium cinnamate) is converted into phenylalanine and excreted from the body through metabolism. A small amount of phenylalanine can be catalyzed by phenylalanine hydroxylase to generate tyrosine, which has no toxic side effects on the human body.

[0007] Specifically, the cinnamates selected in this study (sodium cinnamate and potassium cinnamate) exhibit good safety profiles in terms of oral toxicity, skin irritation, and eye irritation. Furthermore, at pH 5 (the common pH range for daily chemical products is 4-8), the cinnamates (sodium cinnamate and potassium cinnamate) show low minimum inhibitory concentrations (MICs) against common bacteria, particularly yeasts and fungi, demonstrating outstanding broad-spectrum antibacterial efficacy. The performance evaluation of the safety and antibacterial properties of the cinnamates selected in this study is shown in Tables 1 and 2 below:

[0008] Table 1. Safety Performance of Cinnamate Compared with Other Microbial Control Ingredients

[0009]

[0010] Regarding the design of Table 1, this scheme selects cinnamate as a safety performance comparison with other conventional mild microbial control ingredients on the market in terms of oral acute toxicity, skin irritation and sensitization rate, eye irritation rate, genotoxicity, carcinogenicity, and developmental and reproductive toxicity. As can be seen from Table 1, sodium cinnamate and potassium cinnamate are equivalent to or better safe in terms of oral toxicity, skin irritation and eye irritation compared with other mild microbial control ingredients.

[0011] Table 2. Antimicrobial effects of cinnamate compared to other microbial control components.

[0012]

[0013]

[0014] Regarding the design of Table 2, this scheme selects the minimum inhibitory concentration (MIC) as a characterization of the inhibitory effect of the microbial control ingredients on microorganisms. The smaller the MIC value, the better the antibacterial effect. As can be seen from the MIC values ​​in Table 2, compared with commercially available mild and green microbial control ingredients, potassium cinnamate and sodium cinnamate have the lowest MIC values ​​against common bacteria, especially yeasts and fungi, at pH=5 (the commonly used pH range for daily chemical products is 4-8). This indicates that their broad-spectrum antibacterial efficacy is outstanding and superior to other schemes.

[0015] Furthermore, it should be noted that this method of selecting potassium cinnamate and sodium cinnamate as cinnamate salts, compared to directly adding cinnamic acid, offers advantages such as lower odor, a more neutral pH, and safer storage. These advantages are crucial for the use and storage of daily chemical products. Specifically, consumers consider not only the efficacy but also the scent of daily chemical products when purchasing and using them. Potassium cinnamate and sodium cinnamate, as chemicals with low odor, can provide antibacterial effects while maintaining a pleasant smell. In addition, since daily chemical products contain various other chemical components, the neutral pH of cinnamate salts ensures that they are less likely to react with other chemical components, thus guaranteeing preservative effects and extending the daily shelf life of daily chemical products.

[0016] In some embodiments, the cinnamate in the microbial control composition provided by this solution alters the cell membrane permeability of microorganisms and disrupts cell membrane integrity by acting on the cell wall and cell membrane system of microorganisms, thereby promoting metabolic disorders and even death of microorganisms; at the same time, cinnamate controls the growth of microorganisms by acting on biochemical reaction enzymes or other active substances, genetic material or genetic particles, and inhibiting spore germination.

[0017] In some embodiments, the microbial inhibitory synergists in the microbial control composition include, but are not limited to, one or more combinations of diol / alcohol synergists, polyol ester synergists, organic acid synergists, phenolic derivative synergists, amino acid synergists, special zinc salt synergists, plant extract synergists, bioactive substance synergists, cationic bactericide synergists, and antifungal synergists.

[0018] In some embodiments, when the microbial inhibitory synergist is a diol / alcohol synergist, the synergist reduces liquid tension and increases the permeability of microbial cell membranes, allowing cinnamate to diffuse and be transported more quickly to the target microorganisms, thus achieving a synergistic effect. Simultaneously, the diol / alcohol synergist can also denature proteins and enzymes, increasing the antibacterial mechanism pathway and reducing the probability of microbial resistance.

[0019] When the microbial inhibitory synergist is a diol / alcohol synergist, the microbial inhibitory synergist is selected from one or more combinations of 1,3-propanediol, 1,2-butanediol, 1,4-butanediol, 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, octyl glycol, 1,2-decanediol, 1,10-decanediol, ethylhexylglycerol, benzyl alcohol, phenethyl alcohol, phenylpropanol, phenoxyethanol, and dichlorobenzyl alcohol.

[0020] In some embodiments, when the microbial inhibitory synergist is a polyol ester synergist, the microbial inhibitory synergist affects the interfacial tension of the microbial cell membrane, assisting cinnamate in penetrating into the microbial cell to exert a synergistic effect of inhibiting growth.

[0021] When the microbial inhibitory synergist is a polyol ester synergist, the microbial inhibitory synergist is selected from one or more combinations of caprylic acid glyceride, propylene glycol caprylate, caprylic acid glyceride, laurate glyceride, sorbitan caprylate, and chlorphenesin.

[0022] In some embodiments, when the microbial inhibitor is an organic acid synergist, the microbial inhibitor penetrates the microbial cell membrane, altering the intracellular pH of the microorganism, and cinnamate maintains its active organic acid state, enhancing its activity to achieve a synergistic effect. It should be noted that different organic acid synergists have different isoelectric points and penetrating powers; therefore, different organic acid synergists can also compensate for each other's weaknesses.

[0023] When the microbial inhibitory synergist is an organic acid synergist, the microbial inhibitory synergist is selected from one or more combinations of benzoic acid, sorbic acid, dehydroacetic acid, acetylpropionic acid, anisic acid, lactic acid, phytic acid, capryloyl hydroxamic acid, ferulic acid, caffeic acid, salicylic acid, EDTA, GLDA, tartaric acid, citric acid, malic acid, salicylic acid, glycolic acid, kojic acid, undecenoyl phenylalanine, and ascorbic acid.

[0024] In some embodiments, when the microbial inhibitor is a phenolic derivative synergist, the microbial inhibitor disrupts the permeability of the microbial cell membrane, synergistically assisting cinnamate in acting on the cell membrane sites of the microbial cell and entering the microbial cell. Specifically, the phenolic derivative synergist has a phenolic hydroxyl structure, which can interact with the cell membrane and cell wall to disrupt cell membrane permeability.

[0025] When the microbial inhibitory synergist is a phenolic derivative synergist, the microbial inhibitory synergist is selected from one or more combinations of p-hydroxyacetophenone, raspberry ketone or raspberry extract, paeonol cymene-5-ol, maltol, ethyl maltol, vanillin, methyl vanillin, ethyl vanillin, thymol / thymol, and parabens.

[0026] In some embodiments, when the microbial inhibitor is an amino acid-based synergist, the synergist ionizes under the pH of the personal care product to disrupt the integrity of the microbial cell membrane. Cinnamate then penetrates into the microorganisms, synergistically inhibiting their proliferation. Specifically, the amino acids in the amino acid-based synergist ionize to form organic acid segments, which are cationic in nature. These long-chain cations are attracted to the negatively charged surface of the microbial single cell. The organic acid segments insert into the phospholipid bilayer, blocking metabolic channels and disrupting the cell membrane's integrity. This promotes the penetration of cinnamate and cinnamic acid into the cell, altering the intracellular pH, inhibiting intracellular metabolism, and suppressing microbial proliferation.

[0027] When the microbial inhibitory synergist is an amino acid synergist, the microbial inhibitory synergist is selected from one or more combinations of capryloyl glycine, lauroyl glycine, polylysine, and lauroyl arginine ethyl ester.

[0028] In some embodiments, when the microbial inhibitory synergist is a specific zinc synergist, the synergist releases zinc ions to bind to the cell membrane and membrane proteins of microorganisms. The antibacterial sites of the zinc salt are either identical or complementary to the action sites of the cinnamic acid salt, resulting in a synergistic effect. Specifically, the specific zinc synergist slowly releases zinc ions, which have redox properties and can react with organic matter (thiogroups, carboxyl groups, hydroxyl groups), thereby binding to the bacterial cell membrane and membrane proteins of microorganisms to disrupt their structure. After entering the cell, the zinc ions disrupt the enzymes of the electron transport system and react with DNA to achieve the antibacterial purpose. At the same time, after killing bacteria, the zinc ions can be released from the microbial cell, repeating the above bactericidal process. In addition, the antibacterial action sites of the zinc salt and the action sites of the cinnamic acid salt are both identical and complementary, and the combination increases the broad spectrum of antibacterial activity and increases the difficulty of developing drug resistance through mutation.

[0029] When the microbial inhibitory synergist is a special zinc synergist, the microbial inhibitory synergist is selected from one or more combinations of zinc lactate, zinc glycinate, zinc citrate, zinc gluconate, zinc pyrithione, and zinc ricinoleate.

[0030] In some embodiments, when the microbial inhibitor is a bioactive synergist, its spatial configuration consists of a hydrophilic end and a hydrophobic end. The synergist inserts into the cell membrane of the microorganism, disrupting its structure. Cinnamate then penetrates the damaged cell membrane, acting synergistically. Specifically, the hydrophobic end of the synergist inserts into the phospholipid bilayer of the microorganism, while the hydrophilic end faces the extracellular aqueous phase. This interferes with the permeability and metabolism of the microbial cell membrane. The damaged cell membrane facilitates the penetration of cinnamate into the cell, altering the intracellular pH and further disrupting or even halting metabolism.

[0031] When the microbial inhibitory synergist is a biologically derived active ingredient synergist, the microbial inhibitory synergist is selected from one or more combinations of lipopeptides, rhamnolipids, sophorolipids, lactic acid nisin and lactic acid bacteria fermentation products, lysozyme, silkworm peptides and chitosan, among which Bacillus subtilis is preferred as the lipopeptide. When the microbial inhibitory synergist is lysozyme, lysozyme has a decomposing effect on glucan and peptidoglycan in the cell wall of microorganisms, resulting in the destruction of the cell wall structure and loss of strength and support.

[0032] In some embodiments, when the microbial inhibitor is a cationic bactericide synergist, it adsorbs onto the negatively charged surface of the microbial membrane, disrupting the membrane structure. Cinnamate then penetrates the damaged cell membrane, exerting a synergistic effect. Specifically, because cationic bactericide synergists are positively charged, they readily adsorb onto the surface of negatively charged microbial cell membranes. In this case, the hydrophobic end of the cationic bactericide synergist is embedded in the phospholipid bilayer, while the hydrophilic end faces the extracellular aqueous phase, interfering with the permeability and metabolism of the microbial cell membrane. The damaged microbial cell membrane facilitates the penetration of cinnamate into the cell to alter the intracellular pH, further disrupting or even halting metabolism.

[0033] When the microbial inhibitor is a cationic bactericide synergist, the microbial inhibitor is selected from one or more combinations of benzalkonium chloride, dialcyldimethylammonium chloride, polyhexamethylene biguanide (polyaminopropyl biguanide) and its hydrochloride, polyhexamethylene monoguanide, benzyl chloride, cetylpyridinium chloride, chlorhexidine gluconate and domiphen.

[0034] In some embodiments, when the microbial inhibitory synergist is an antifungal synergist, the microbial inhibitory synergist acts on the cell membrane of microorganisms, altering the cell membrane structure. Cinnamate penetrates the damaged cell membrane, exerting a synergistic effect. Specifically, the antifungal synergist acts on the cell membrane of microorganisms, inhibiting the transport of substrates such as leucine, thereby causing changes in the cell membrane and ultimately leading to cell membrane rupture. Simultaneously, the antifungal synergist forms a complex with iron ions, inhibiting mitochondrial energy metabolism in fungi, thus achieving inhibitory and bactericidal effects.

[0035] When the microbial inhibitor is an antifungal synergist, the microbial inhibitor is selected from pyroximate ethanolamine salt.

[0036] In addition, when the microbial inhibitory synergist is a plant extract synergist, the microbial inhibitory synergist is selected from one or more combinations of cinnamyl alcohol, cinnamaldehyde and cinnamon extract, citral, limonene and lemon extract, eugenol and clove flower extract, matrine, total alkaloids of matrine and matrine extract, cypressol and cypress / thuja extract, magnolol, honokiol and magnolia bark extract, berberine and phellodendron bark, coptis extract, myricetin, dihydromyricetin and vine tea extract, grape seed extract, grapefruit seed extract, tea polyphenols, artemisia capillaris extract, rosmarinic acid and rosemary extract, and linalool and linalool extract.

[0037] It should be noted that when the microbial inhibitory synergist is cinnamyl alcohol, cinnamaldehyde, or cinnamon extract, the synergist disrupts the structure and integrity of the microorganisms, and cinnamate penetrates the damaged cell membrane to exert a synergistic effect. Specifically, cinnamaldehyde can disrupt the structural and functional integrity of bacteria or fungi. Cinnamaldehyde can specifically inhibit the synthesis of glucan and chitin in the fungal cell wall and can penetrate barriers such as the cell wall to act on glucan synthase and chitin synthase located on the cell membrane, thereby inhibiting the growth of fungal cells.

[0038] When the microbial inhibitory synergists are citral, limonene, and lemon extract, they reduce the content of unsaturated fatty acids in the cell membrane of microorganisms, thereby disrupting the cell membrane structure. Cinnamate penetrates the damaged cell membrane and plays a synergistic role. Specifically, citral, limonene, and lemon extract can reduce the content of unsaturated fatty acids in the cell membrane, disrupting the cell membrane structure and enhancing the cell membrane disruption effect of cinnamate, making it easier for cinnamate to enter the cell and complete its intracellular action.

[0039] When the synergistic agents for microbial inhibition are eugenol and clove flower extract, they act on the phospholipid bilayer of the cell membrane, increasing cell membrane permeability to disrupt the cell membrane structure of microorganisms. Cinnamate then penetrates the damaged cell membrane, playing a synergistic role. Specifically, eugenol and clove flower extract act on the phospholipid bilayer of the cell membrane, increasing cell membrane permeability and disrupting the cell membrane and even the cell wall. This enhances the disruptive effect of cinnamate on the cell membrane, making it easier for cinnamate to enter the cell and complete its intracellular action.

[0040] When the microbial inhibitory synergist is matrine, total matrine, or matrine extract, the microbial inhibitory synergist inhibits the DNA synthesis of microbial cells to prevent the growth and reproduction of microorganisms, and synergistically interferes with and inhibits the genetic material of microorganisms by cinnamate.

[0041] When the microbial inhibitory synergists are physalisol, juniperol, and cypress / thuja extracts, these synergists inhibit microbial respiration and nutrient absorption, and synergistically interfere with microbial metabolic functions through cinnamate. Specifically, physalisol, juniperol, and cypress / thuja extracts inhibit bacterial respiration and nutrient utilization, while cinnamate, acting on cell membrane sites, further interferes with cell membrane metabolic functions, exacerbating metabolic disorders and nutrient deficiencies in microorganisms.

[0042] When the microbial inhibitory synergists are magnolol, honokiol, and magnolia bark extract, these synergists affect the permeability of microbial cell membranes and disrupt cell membranes, synergistically penetrating the cell membranes with cinnamate. Specifically, magnolol, honokiol, and magnolia bark extract can increase the production of reactive oxygen species and disrupt mitochondrial function to induce apoptosis and necrosis, thereby affecting cell membrane permeability. The binding of magnolol, honokiol, and magnolia bark extract with ergosterol also disrupts the cell wall. This disruption of the cell wall and cell membrane helps cinnamate penetrate the cell wall more easily, further acting on the cell membrane and intracellular space, accelerating microbial death.

[0043] When the synergistic agents for microbial inhibition are berberine, phellodendron bark extract, and coptis chinensis extract, these agents limit the utilization of vitamin B6 and nicotinamide by microorganisms, interfere with normal microbial metabolism, and synergistically inhibit microbial genetic material while interfering with microbial metabolism, in conjunction with cinnamate. Specifically, berberine, phellodendron bark extract, and coptis chinensis extract compete with the microbial coenzyme pyridoxal phosphate for enzyme proteins on tyrosine decarboxylase and tryptophanase, while simultaneously inhibiting pyruvate oxidation in the bacterial sugar metabolism process. This limits the bacteria's utilization of vitamin B6 and nicotinamide, interfering with normal microbial metabolism to inhibit the synthesis of DNA, RNA, proteins, and lipids, thus interfering with bacterial reproduction. The pathway by which berberine, phellodendron bark extract, and coptis chinensis extract interfere with intracellular metabolism differs from the interference caused by cinnamate altering pH. These two mechanisms have complementary effects, and their interference with the inhibition of genetic material also has complementary effects, resulting in a significant synergistic effect.

[0044] When the microbial inhibitory synergists are myricetin, dihydromyricetin, vine tea extract, and grapefruit seed extract, the microbial inhibitory synergists inhibit the growth, development, and reproduction of microorganisms, and work synergistically with cinnamate to inhibit microbial growth. Specifically, myricetin, dihydromyricetin, vine tea extract, and grapefruit seed extract inhibit bacterial growth, development, and reproduction in three ways: (1) In the process of microbial sugar metabolism, by interfering with its respiratory metabolic pathway, it inhibits the synthesis of ATP required for bacterial growth activities, reduces the metabolism of microorganisms, and thus leads to the inability of bacteria to grow, develop, and reproduce normally, ultimately leading to death; (2) By destroying the integrity of the bacterial cell membrane and cell wall, it causes the loss of intracellular nutrients and inorganic salts, leading to dysfunction of the cell membrane fluidity membrane, and at the same time, it has a certain impact on the activity of ATP, ultimately leading to the inability of microbial RNA to be synthesized normally; (3) By interfering with the normal synthesis of genetic material DNA, RNA, or protein in microorganisms, it leads to a decrease in the synthesis of bacterial proteins, especially specific catalytic enzymes, or to the occurrence of denaturation and coagulation, ultimately inhibiting bacterial growth or causing its death.

[0045] When the microbial inhibitory synergists are grape seed extract and tea polyphenols, these synergists inhibit microbial enzymes and protein expression, and synergistically inhibit microbial growth with cinnamate. Specifically, grape seed extract and tea polyphenols have inhibitory effects on microbial enzymes, which in turn affect protein expression, and they can also chelate metal ions within microbial cells to inhibit microbial growth.

[0046] When the microbial inhibitory synergists are Artemisia capillaris extract, rosmarinic acid, and rosemary extract, these synergists disrupt bacterial cell walls, altering cell membrane permeability and integrity, and synergistically eliminate microorganisms with cinnamate. Specifically, Artemisia capillaris extract, rosmarinic acid, and rosemary extract can disrupt bacterial cell walls, damage both the outer and inner membranes, alter and disrupt cell membrane permeability and integrity, causing extracellular leakage of intracellular substances.

[0047] When the microbial inhibitory synergist is linalool and linalool extract, the synergist disrupts the cell wall and cell membrane of Escherichia coli, synergistically eliminating microorganisms with carboxylic acid. Specifically, linalool not only disrupts the cell wall of E. coli but also the cell membrane, leading to leakage of intracellular substances and causing E. coli to appear shrunken and shriveled.

[0048] In some embodiments, the weight ratio of cinnamate to microbial inhibitor synergist in the cinnamate-based microbial control composition is from 10:90 to 90:10. Preferably, the weight ratio of cinnamate to microbial inhibitor synergist is 30:70 or 40:60.

[0049] In addition, in some embodiments, the cinnamate is of natural plant origin or natural fermentation origin or is obtained synthetically or semi-synthetically.

[0050] Secondly, this solution provides an application of a meat silicate-based microbial control composition in daily chemical products. Correspondingly, a daily chemical product includes the aforementioned meat silicate-based microbial control composition in a predetermined proportion, as well as a personal care chemical component.

[0051] In embodiments of this solution, the total concentration of the meat silicate-based microbial control composition added to the daily chemical products is 0.001-10%. Preferably, the total concentration of the meat silicate-based microbial control composition added to the daily chemical products is 5%.

[0052] In some embodiments, the types of daily chemical products include, but are not limited to, detergents, cosmetics, care products, and toiletries. Cosmetics include, but are not limited to, one of the following: pressed powder, lipstick, lip oil, eyeshadow (cream, liquid, pressed), eyebrow pencil (pressed), eyeliner (pressed), mascara (liquid), cream (cream), nourishing gel, toner (spray), and face mask. Toiletries include, but are not limited to, one of the following: shampoo, conditioner, makeup remover, lotion, soap, liquid soap, shower gel, shower cream, essential oil, shaving cream, hair removal cream, bath soap, shower gel, toothpaste, and teeth whitening mousse. Care products include, but are not limited to, one of the following: sunscreen (spray, lotion, gel), perfume, cologne, nourishing liquid, antiperspirant, and hair removal cream. Detergents include, but are not limited to, one of the following: wet wipes, deodorant, detergent, laundry detergent, and dish soap. It should be noted that the chemical components in the daily chemical products vary depending on the type of daily chemical product.

[0053] In some embodiments, the application forms of daily chemical products include, but are not limited to, one of the following: bar, roll-on, spray, aerosol, soap bar, powder, solution, gel, cream, balm, and lotion.

[0054] In some embodiments, daily chemical products include excipient components, wherein the excipient components include, but are not limited to, surfactants, emulsifiers, oils, chelating agents, pH adjusters, fragrances, defoamers, fillers, pigments, antioxidants, bactericides, deodorants, sunscreens, natural or synthetic fiber fabrics, water, and ethanol, or a combination of two or more of these components.

[0055] Compared with existing technologies, this technical solution has the following characteristics and beneficial effects:

[0056] This solution incorporates cinnamate, a safe and antibacterial agent, as a microbial control component in daily chemical products. It also works synergistically with various microbial inhibitors to inhibit microbial growth. In other words, this solution provides a novel microbial control composition for daily chemical products that enhances microbial inhibition while maintaining mildness and safety. Detailed Implementation

[0057] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention are within the scope of protection of the present invention.

[0058] It is understood that the term "a" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of an element can be one, while in another embodiment, the number of the element can be multiple, and the term "a" should not be understood as a limitation on the number.

[0059] Example 1: Octyl glycol and phenoxyethanol were mixed in a mass ratio of 1:2 as microbial inhibitory synergists, and potassium cinnamate was used as a cinnamate salt. Microbial control compositions 1.1, 1.2, 1.3, 1.4 and 1.5 were obtained by mixing potassium cinnamate and microbial inhibitory synergists in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10, respectively.

[0060] Example 2: Using sodium carnitine as carnitine silicate, microbial control compositions 2.1, 2.2, 2.3, 2.4 and 2.5 were obtained by mixing sodium cinnamate and propylene glycol octanoate in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0061] Example 3: Using potassium cinnamate as the cinnamate silicate, microbial control compositions 3.1, 3.2, 3.3, 3.4 and 3.5 were obtained by mixing potassium cinnamate and levulinic acid in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0062] Example 4: Using sodium carnitine as carnitine silicate, microbial control compositions 4.1, 4.2, 4.3, 4.4 and 4.5 were obtained by mixing sodium cinnamate and p-hydroxyacetophenone in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10 respectively.

[0063] Example 5: Polylysine and ethyl lauroyl arginine were mixed in a 1:1 mass ratio as microbial inhibitory synergists, and potassium cinnamate was used as cinnamate silicate. Microbial control compositions 5.1, 5.2, 5.3, 5.4 and 5.5 were obtained by mixing potassium cinnamate and microbial inhibitory synergists in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10, respectively.

[0064] Example 6: Zinc lactate and zinc gluconate were mixed in a 1:1 mass ratio as microbial inhibitory synergists, and sodium cinnamate was used as cinnamate silicate. The microbial control compositions 6.1, 6.2, 6.3, 6.4 and 6.5 were obtained by mixing sodium cinnamate and microbial inhibitory synergists in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10, respectively.

[0065] Example 7: Using potassium cinnamate as the cinnamate silicate, microbial control compositions 7.1, 7.2, 7.3, 7.4 and 7.5 were obtained by mixing potassium cinnamate and cypress / arborvitae extracts in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0066] Example 8: Using sodium carnitine as carnitine silicate, microbial control compositions 8.1, 8.2, 8.3, 8.4 and 8.5 were obtained by mixing sodium cinnamate and vine tea extract in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0067] Example 9: Using potassium cinnamate as the cinnamate silicate, microbial control compositions 9.1, 9.2, 9.3, 9.4 and 9.5 were obtained by mixing potassium cinnamate and cephalosporin in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0068] Example 10: Using sodium cinnamate as the cinnamate silicate, microbial control compositions 10.1, 10.2, 10.3, 10.4 and 10.5 were obtained by mixing sodium cinnamate and polyhexamethylene biguanide (or polyaminopropyl biguanide) in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10 respectively.

[0069] Example 11: Using potassium cinnamate as the cinnamate silicate, microbial control compositions 11.1, 11.2, 11.3, 11.4 and 11.5 were obtained by mixing potassium cinnamate and piroctone ethanolamine salt in ratios of 10:90, 25:75, 50:50, 75:25 and 90:10.

[0070] Example 12: Potassium cinnamate was added only.

[0071] Example 13: Sodium carboxylate was added only.

[0072] Comparative Example 1: Octyl glycol and phenoxyethanol were mixed in a mass ratio of 1:2 as a microbial inhibitory synergist.

[0073] Comparative Example 2: Only propylene glycol octanoate was added.

[0074] Comparative Example 3: Only levulinic acid was added.

[0075] Comparative Example 4: Only p-hydroxyacetophenone was added.

[0076] Comparative Example 5: Polylysine and ethyl lauroyl arginine were mixed in a 1:1 mass ratio as a microbial inhibitory synergist.

[0077] Comparative Example 6: Zinc lactate and zinc gluconate were mixed in a 1:1 mass ratio as a microbial inhibitory synergist.

[0078] Comparative Example 7: Only cypress / arborvitae extract was added.

[0079] Comparative Example 8: Only vine tea extract was added.

[0080] Comparative Example 9: Only silkworm peptides were added.

[0081] Comparative Example 10: Only polyhexamethylene biguanide (or polyaminopropyl biguanide) was added.

[0082] Comparative Example 11: Only pyrrolidone ethanolamine salt was added.

[0083] Example 1 of Microbial Inhibition Control Test (Shampoos or Shower Gels, pH=5.5):

[0084] Shampoos or shower gels were prepared using the microbial control compositions of Examples 1, 2, 6, 9, 11, 12, and 13 and the corresponding comparative examples. The formulations of the shampoos prepared were as follows: deionized water balance; EDTA-2Na 0.1%; AES (70%) 15%; cocamidopropyl betaine (35%) 10%; sodium chloride 0.8%; microbial control composition 0.5%; and citric acid as needed.

[0085] The formula of the prepared shower gel is as follows: deionized water balance; EDTA-2Na 0.1%; AES (70%) 15%; cocamidopropyl betaine (35%) 10%; sodium chloride 0.8%; microbial control composition 0.5%; citric acid appropriate amount.

[0086] Table 3 shows the results of measuring the microbial residue levels in the prepared shampoos or shower gels.

[0087] Table 3. Measurement values ​​of microbial residues in shampoos or shower gels.

[0088]

[0089]

[0090]

[0091] Regarding the design of Table 3, the bacteria (a mixture of Staphylococcus aureus ATCC6538, Escherichia coli ATCC8739, and Pseudomonas aeruginosa ATCC9027) in Table 3 are represented by B, the yeast (Candida albicans ATCC10231) is represented by Y, and the mold (Aspergillus niger ATCC 16404) is represented by M. As can be seen from Table 3, the microbial control composition provided by this scheme can effectively inhibit microorganisms.

[0092] Example 2 of Microbial Inhibition Control Test (Toner, pH=5.5):

[0093] The microbial control compositions of Examples 10, 12, and 13, as well as Comparative Example 10, were used to prepare a cosmetic lotion. The formula of the prepared cosmetic lotion is as follows: deionized water balance; glycerin 3%; 1,3-butanediol 5%; trehalose 0.8-1.0%; allantoin 0.1%; microbial control composition 0.5%; citric acid appropriate amount.

[0094] The microbial residue levels of the prepared toner were measured, as shown in Table 4.

[0095] Table 4 Microbial Residue Values ​​of Toners

[0096]

[0097] Example 3 of Microbial Inhibition Control Test (Emulsion, pH=5.5):

[0098] Emulsions were prepared from the microbial control compositions of Examples 3 and 4, Examples 12 and 13, and Comparative Examples 3 and 4. The formulations of the prepared emulsions are as follows: deionized water balance; acrylate / C10-30 alcohol acrylate crosspolymer potassium 0.3%; glycerol 2.5%; 1,3-butanediol 5.0%; betaine 1.0%; trehalose 1.0%; cetearyl alcohol 1.0%; polydimethylsiloxane 1.0%; isononyl isononanoate 2.0%; PEG-100 stearate 2.0%; microbial control composition 0.5%; triethanolamine 0.8%.

[0099] The microbial residue levels of the prepared emulsion were measured, as shown in Table 5.

[0100] Table 5 Microbial Residue Values ​​of Emulsions

[0101]

[0102]

[0103] Example 4 of Microbial Inhibition Control Test (Cream, pH=5.7):

[0104] Creams were prepared using the microbial control compositions from Examples 7 and 8, Examples 12 and 13, and Comparative Examples 7 and 8. The formulations of the prepared creams are as follows: deionized water balance; glycerin 4.3%; 1,3-butanediol 5.0%; allantoin 0.1%; acrylate / C10-30 alcohol acrylate crosspolymer potassium salt 0.3%; seaweed 1.0%; cetearyl alcohol 3.0%; caprylic / capric triglyceride 10.0%; polydimethylsiloxane 1.0%; isononyl isononanoate 4.0%; PEG-100 stearate 3.5%; microbial control composition 0.5%.

[0105] The microbial residue levels of the prepared cream were measured and shown in Table 6.

[0106] Table 6. Measurement values ​​of microbial residues in creams

[0107]

[0108]

[0109] Microbial inhibition control test example five (wet wipes, (solid weight: liquid weight = 1:3) (pH = 5.5)): Wet wipes were prepared from the microbial control compositions of Examples 9, 10, 12, 13, 9, and 10, with the following formulation: liquid: water balance, Tween-20 0.2%, sodium citrate / citric acid appropriate amount, microbial control composition 0.3%; nonwoven fabric: viscose: wood glue = 50:50.

[0110] The microbial residue levels of the prepared wet wipes were measured, and the results are shown in Table 7.

[0111]

[0112]

[0113] Microbial inhibition control test example six (makeup remover, pH=5.7):

[0114] Makeup remover was prepared using the microbial control compositions of Examples 2, 5, 12, and 13, as well as Comparative Examples 5 and 2. The formulation of the prepared makeup remover is as follows: deionized water balance; disodium EDTA 0.05%; PEG-6 caprylic / capric glycerides 5.0%; microbial control composition 0.3%; dipropylene glycol 3.0%.

[0115] The microbial residue levels of the prepared makeup remover were measured, as shown in Table 8.

[0116] Table 8. Measurement values ​​of microbial residues in makeup remover.

[0117]

[0118]

[0119] Microbial inhibition control test example seven (facial mask liquid, pH=5.7):

[0120] The microbial control compositions of Examples 5, 12, and 13, as well as Comparative Example 5, were used to prepare a facial mask liquid. The formulation of the prepared facial mask liquid is as follows: deionized water balance; glycerin 3.6%; 1,3-butanediol 5.0%; allantoin 0.1%; sodium hyaluronate 0.1%; acrylate / C10-30 alcohol acrylate crosspolymer potassium salt 0.15%; hydroxyethyl cellulose 0.1%; trehalose 1.0%; microbial control composition 0.3%.

[0121] The microbial residue levels of the prepared facial mask liquid were measured, as shown in Table 8.

[0122]

[0123]

[0124] This invention is not limited to the preferred embodiments described above. Anyone can derive other products in various forms under the guidance of this invention. However, regardless of any changes in shape or structure, any technical solution that is the same as or similar to this application falls within the protection scope of this invention.

Claims

1. A microbial control composition based on cinnamate, characterized in that, include: A predetermined ratio of cinnamate and a microbial inhibitory synergist, wherein the cinnamate is selected from sodium cinnamate and potassium cinnamate or a combination thereof.

2. The cinnamate-based microbial control composition according to claim 1, characterized in that, The microbial inhibitory synergists in the microbial control composition include, but are not limited to, one or more combinations of diol / alcohol synergists, polyol ester synergists, organic acid synergists, phenolic derivative synergists, amino acid synergists, special zinc salt synergists, plant extract synergists, bioactive substance synergists, cationic bactericide synergists, and antifungal synergists.

3. The cinnamate-based microbial control composition according to claim 1, characterized in that, The weight ratio of cinnamate to microbial inhibitor synergist is 10:90 to 90:

10.

4. The cinnamate-based microbial control composition according to claim 2, characterized in that, When the microbial inhibitory synergist is a diol / alcohol synergist, the synergist is selected from one or more combinations of 1,3-propanediol, 1,2-butanediol, 1,4-butanediol, 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, octyl glycol, 1,2-decanediol, 1,10-decanediol, ethylhexylglycerin, benzyl alcohol, phenethyl alcohol, phenylpropanol, phenoxyethanol, and dichlorobenzyl alcohol; when the microbial inhibitory synergist is a polyol ester synergist, the synergist is selected from glyceryl caprylate, propylene glycol caprylate, glyceryl caprylate, and glyceryl tartrate. The microbial inhibitor is selected from one or more combinations of glyceryl cinnamate, sorbitan caprylate, and chlorphenesin; when the microbial inhibitor is an organic acid synergist, the microbial inhibitor is selected from one or more combinations of benzoic acid, sorbic acid, dehydroacetic acid, levulinic acid, anisic acid, lactic acid, phytic acid, capryloyl hydroxamic acid, ferulic acid, caffeic acid, salicylic acid, EDTA, GLDA, tartaric acid, citric acid, malic acid, salicylic acid, glycolic acid, kojic acid, undecenoyl phenylalanine, and ascorbic acid; when the microbial inhibitor is a phenolic derivative synergist, the microbial inhibitor is selected from p-hydroxyacetophenone, The microbial inhibitor is selected from one or more combinations of raspberry ketone or raspberry extract, paeonol, cymene-5-ol, maltol, ethyl maltol, vanillin, methyl vanillin, ethyl vanillin, thymol / thymol, and parabens; when the microbial inhibitor is an amino acid synergist, the microbial inhibitor is selected from one or more combinations of capryloyl glycine, lauroyl glycine, polylysine, and lauroyl arginine ethyl ester; when the microbial inhibitor is a specific zinc synergist, the microbial inhibitor is selected from zinc lactate, zinc glycinate, zinc citrate, zinc gluconate, zinc pyrithione, and ricinoleic acid. One or more combinations of zinc; when the microbial inhibitor is a bioactive synergist, the microbial inhibitor is selected from one or more combinations of lipopeptides, rhamnolipids, sophorolipids, nisin and lactic acid bacteria fermentation products, lysozyme, silkworm peptides and chitosan; when the microbial inhibitor is a cationic bactericide synergist, the microbial inhibitor is selected from one or more combinations of benzalkonium chloride, dialcyldimethylammonium chloride, polyhexamethylene biguanide or polyaminopropyl biguanide and its hydrochloride, polyhexamethylene monoguanide, benzyl chloride, cetylpyridinium chloride, chlorhexidine gluconate and domiphen.When the microbial inhibitory synergist is a plant extract synergist, the microbial inhibitory synergist is selected from one or more combinations of cinnamyl alcohol, cinnamaldehyde and cinnamon extract, citral, limonene and lemon extract, eugenol and clove flower extract, matrine, total alkaloids of matrine and matrine extract, cypressol, juniper alcohol and cypress / thuja extract, magnolol, honokiol and magnolol extract, berberine and phellodendron bark extract, coptis extract, myricetin, dihydromyricetin and vine tea extract, grape seed extract, grapefruit seed extract, tea polyphenols, artemisia capillaris extract, rosmarinic acid and rosemary extract, and linalool and linalool extract.

5. The cinnamate-based microbial control composition according to claim 1, characterized in that, Cinnamates are derived from natural plant sources, natural fermentation sources, or are obtained through synthesis or semi-synthesis.

6. A daily chemical product, characterized in that, The microbial control composition based on cinnamate as described in any one of claims 1 to 4, and daily chemical components, are included in a specified proportion.

7. The daily chemical product according to claim 6, characterized in that, The total concentration of the meat silicate-based microbial control composition added is 0.001-10%.

8. The daily chemical product according to claim 6, characterized in that, Personal care products include, but are not limited to, cosmetics, care products, detergents, and toiletries.

9. The daily chemical product according to claim 6, characterized in that, Daily chemical products can be applied in various forms, including but not limited to bars, roll-ons, sprays, aerosols, soap bars, powders, solutions, gels, creams, balms, and lotions.

10. The daily chemical product according to claim 6, characterized in that, It includes auxiliary components, which include, but are not limited to, surfactants, emulsifiers, oils, chelating agents, pH adjusters, fragrances, defoamers, fillers, pigments, antioxidants, bactericides, deodorants, sunscreens, natural or synthetic fiber fabrics, water, and ethanol, or one or more combinations thereof.

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