Multifunctional atomization administration device for organ transplantation patient

Abstract

The invention discloses a multifunctional atomization drug delivery device for an organ transplantation patient, relates to the technical field of medical instruments, and is used for solving the problems that an existing device is long in backflow guide-back path, much in residual liquid, difficult in drug path switching and sequential drug delivery and the like, and the multifunctional atomization drug delivery device comprises a patient end drug delivery module located at the near end and used for outputting oxygen-containing drug mist to the patient; the mixed oxygen supply module is connected with an air path of the patient end administration module and is used for inhaling and atomizing the liquid medicine under the action of oxygen flow; the medicine supply module is arranged in the mixed oxygen supply module, and the middle and the bottom of the medicine supply module are respectively communicated with the mixed oxygen supply module so as to realize reutilization of the liquid medicine; and the cleaning and drying module is mounted in the middle of the mixed oxygen supply module and is communicated with the patient end dosing module. The device has the effects of stable backflow, sequential dosing and rapid disinfection.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a multifunctional nebulized drug delivery device for organ transplant patients. Background Technology

[0002] Nebulized drug delivery, as an important means of respiratory administration and assisted oxygenation, is widely used in sequential treatment scenarios such as anti-infection, bronchiectasis, expectoration, and hormone therapy for post-organ transplant patients and immunocompromised individuals. These patients often require repeated inhalation of different drugs or staged oxygen therapy over extended periods, placing higher demands on droplet size stability, ease of drug switching, drug utilization rate, and the sterilizability and dryability of tubing, as well as closed-loop infection control. However, traditional nebulizers often employ single-path mixing and single-use output methods, limiting gas-liquid mixing efficiency, making it difficult to control drug residue and condensation reflux. Furthermore, they often require external connection or disassembly for cleaning, resulting in cumbersome operation and increased risk of cross-contamination.

[0003] In the prior art, such as the respiratory precision nebulization drug delivery device disclosed in CN116077770A, there is a shell, an oxygen delivery component, a mixing jet tube, a drug delivery tube, a nebulizing component, and an oxygen mask. The drug delivery tube is connected to the bottom of the mixing jet tube through a pipe. The oxygen delivery component is connected to the mixing jet tube and the drug delivery tube. The end of the mixing jet tube away from the oxygen delivery component is connected to the nebulizing component. This solution can achieve a certain degree of premixing at the mixing jet tube and the drug delivery tube, and achieve nebulization output with the help of the nebulizing component. However, its mixing structure mainly relies on a single jet tube and an external nebulizer to compress the liquid into mist. The gas-liquid mixing and particle size control are easily affected by flow fluctuations, drug viscosity, and channel resistance. At the same time, this solution does not establish a path for the separation and recycling of large droplets of the drug. Residual liquid and large droplets are prone to waste or deposition and blockage, which is also not conducive to maintaining stable particle size and continuous nebulization efficiency.

[0004] Furthermore, transplant patients often require "multi-drug, sequential, and switchable" treatments. Existing devices generally lack an integrated structure for independent, multi-channel circumferential drug delivery and sequential switching, typically requiring the replacement of medication cups or disassembly of tubing for medication changes, leading to operational complexity, drug delivery interruptions, and contamination risks. Moreover, infection control requirements necessitate effective flushing, disinfection, and thorough drying of contaminated areas such as the gas path, mixing chamber, and nozzle after treatment. However, most devices do not integrate cleaning, disinfection, drying, and end-of-line drainage / pressure relief functions into a closed-loop system, often relying on external cleaning, natural air drying, or manual drainage, making standardized process control difficult. Therefore, there is an urgent need for a multifunctional nebulizer drug delivery device that can improve gas-liquid mixing efficiency, enable drug recovery and reuse, and integrate cleaning and drying functions to better meet the requirements of sequential treatment and infection control for transplant patients. Summary of the Invention

[0005] To address the aforementioned problems, this invention aims to provide a multifunctional nebulized drug delivery device for organ transplant patients. Through coaxial dual Venturi systems with micron-level sieve reflux, circumferential multi-drug independent path selection, and in-machine cleaning and drying, it achieves stable droplet delivery, sequential drug administration, and rapid disinfection.

[0006] The main idea of ​​the technical solution adopted in this invention is as follows: An inner and outer Venturi mixing chamber are coaxially arranged in an integrated shell, with micron-level mesh arranged at the inner end to achieve droplet sieving; an annular drug storage tank is arranged around the outer perimeter and divided into multiple storage tanks, with a solenoid valve arranged on the top of the tank. The selected drug solution is injected into the outer Venturi mixing section through the nozzle to complete traction atomization; each drug bottle achieves liquid intake and air pressure balance through a balance bar, forming a repeatable and continuous drug supply; the patient end outputs to the nose and mouth interfaces via a main air path + adjustable pressure valve; the lower part integrates a three-way valve, a disinfectant pump, and a heating air path to complete the switching between three modes: disinfection, drying, and operation, and releases pressure and drains liquid through the end pressure regulating valve, constructing a closed-loop, safe, and easy-to-maintain atomized drug delivery system.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A multifunctional nebulized drug delivery device for organ transplant patients includes: a patient-end drug delivery module located proximally for delivering oxygenated drug mist to the patient; a mixed oxygen supply module connected to the gas path of the patient-end drug delivery module for inhaling and nebulizing the drug solution under the action of oxygen flow; a drug delivery module disposed within the mixed oxygen supply module, with its middle and bottom respectively connected to the mixed oxygen supply module to realize the reuse of the drug solution; and a cleaning and drying module installed in the middle of the mixed oxygen supply module and connected to the patient-end drug delivery module.

[0008] Furthermore, the patient-side drug delivery module includes: a main airway, a three-way connector at the proximal end of the main airway, which is detachably connected to the nasal cannula and the mouthpiece respectively, and an adjustable pressure valve between the distal end of the main airway and the mixed oxygen supply module.

[0009] Furthermore, the hybrid oxygen supply module includes: A hollow shell with multiple accommodating cavities spaced circumferentially; The gas-liquid mixing component is located in the middle of the hollow shell, and its end is connected to the main gas circuit through an adjustable pressure valve; The oxygen supply component is connected to the other end of the gas-liquid mixing component through the cleaning and drying module.

[0010] Furthermore, the gas-liquid mixing assembly includes: The internal Venturi mixing chamber is located in the middle of the hollow shell; The outer Venturi mixing cavity is coaxially fitted outside the inner Venturi mixing cavity to form a ring-shaped mixing zone; Micron-sized mesh is installed at the upper end of the inner Venturi mixing chamber to screen the atomized liquid carried out by the inner Venturi mixing chamber by particle size.

[0011] Furthermore, the drug supply module includes: Medicine bottles, with multiple medicine bottles respectively placed in each receiving cavity; The drug storage assembly is arranged circumferentially around the outer Venturi mixing chamber, with one end connected to the drug bottle and the other end connected to the outer Venturi mixing chamber, forming several independent drug delivery channels; The balanced delivery assembly connects one end to the medication bottle and the other end to the Venturi mixing chamber inside the storage tank to maintain pressure balance inside and outside the medication bottle.

[0012] Furthermore, the drug storage component includes: An annular storage tank is located outside the outer Venturi mixing chamber; The liquid storage tanks are independently opened along the circumference of the annular medicine storage tank; A solenoid valve is installed on the upper part of the liquid storage tank to selectively connect the corresponding liquid storage tank to the outer Venturi mixing chamber.

[0013] Furthermore, the airway balanced drug delivery component includes: The balance bar has one end connected to the medicine bottle and the other end connected to the Neventuri mixing chamber; The liquid dispensing tank is located inside the balance bar and is connected to the liquid storage tank corresponding to the medicine bottle.

[0014] Furthermore, a balancing air passage is formed inside the balance bar. The balancing air passage is connected to the outer Venturi mixing chamber and the inner Venturi mixing chamber through a connecting tube. The connection between the connecting tube and the outer Venturi mixing chamber is a clearance fit to form a micro-leakage to recover the atomizing liquid.

[0015] Furthermore, the cleaning and drying module includes a connector with a through hole in the middle, through which an air supply pipe passes and communicates with the bottom of the gas-liquid mixing component. Inside the connector, a disinfectant storage chamber and a drying chamber are provided separately from each other, and a three-way control valve is provided between the two chambers.

[0016] Furthermore, a drying assembly is installed inside the drying chamber, which includes an air pump, a gas heater, and an air pipe that connects the two in series to a three-way control valve.

[0017] The beneficial effects of this invention are: 1. Through the coaxial inner and outer Venturi mixing chambers and the droplet classification and recovery structure with micron-level mesh, the nozzle injects the drug solution into the outer Venturi mixing section. The fine mist passes through the micron-level mesh and enters the main air path, while larger droplets fall back along the outer cavity wall and are reinjected into the storage tank for reuse through the annular gap between the second cylindrical shell and the hose. As a result, the negative pressure is more stable, the particle size is more concentrated, the drug utilization rate is significantly improved, and the patient's inhalation is more uniform. 2. The annular drug storage tank has six independent storage tanks around its circumference, a top solenoid valve, and a nozzle. Combined with the bottom balance bar and dispensing tank, it forms a multi-channel independent drug supply system that can be switched one or in sequence. Switching does not require disassembling the tubing, and the storage tanks have little interference with each other. Multiple drug combinations and individualized plans can be quickly completed according to the doctor's orders, which significantly improves treatment efficiency and dosage accuracy.

[0018] 3. The bottom cleaning and drying module integrates a three-way control valve, water pump, air pump and gas heater. After treatment, it can switch to a closed-loop process of "disinfection-rinse-drying" with one click. The end is depressurized and drained by an adjustable pressure valve. It can complete rapid disinfection and drying without external disassembly and soaking, shortening the turnaround time, reducing the risk of infection and maintenance costs, and improving the overall safety and usability. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the patient-side drug delivery module of the present invention; Figure 3 This is a schematic diagram of the structure of the hybrid oxygen supply module of the present invention; Figure 4 This is a schematic diagram of the internal structure of the hybrid oxygen supply module of the present invention; Figure 5 This is a top view of the hybrid oxygen supply module of the present invention; Figure 6 This is a cross-section of the hybrid oxygen supply module and drug supply module of the present invention. Figure 1 ; Figure 7 This is a cross-section of the hybrid oxygen supply module and drug supply module of the present invention. Figure 2 ; Figure 8 This is a cross-sectional view of the airway balanced drug delivery component of the present invention; Figure 9 This is a schematic diagram of the balance bar structure of the present invention; Figure 10 This is a schematic diagram of the cleaning and drying module of the present invention; Figure 11 This is a schematic diagram of the internal structure of the cleaning and drying module of the present invention; Figure 12 for Figure 7 A schematic diagram of the structure at point A; Figure 13 The product of this invention Figure 1 ; Figure 14 The product of this invention Figure 2 ; Figure 15 The product of this invention Figure 3 ; Figure 16 The product of this invention Figure 4 ; The module includes: 1. Patient-side drug delivery module; 11. Main airway; 111. Adjustable pressure valve; 112. Three-way connector; 12. Nasal cannula; 13. Mouthpiece; 2. Mixed oxygen supply module; 21. Hollow shell; 211. Receptacle; 2111. Elastic seal; 22. Gas-liquid mixing assembly; 221. Inner Venturi mixing chamber; 2211. First cylindrical shell; 2212. Inner Venturi mixing tube; 222. Outer Venturi mixing chamber; 2221. Second cylindrical shell; 2222. Outer Venturi mixing tube; 2223. Nozzle; 2224. Mixing section; 223. Micron-level mesh; 23. 1. Oxygen supply module; 231. Gas cylinder; 232. Power component; 233. Gas delivery pipe; 3. Drug supply module; 31. Drug bottle; 32. Drug storage module; 321. Ring-shaped drug storage tank; 322. Liquid storage tank; 323. Solenoid valve; 33. Airway balanced drug delivery module; 331. Balance bar; 332. Liquid collection tank; 333. Balanced airway; 334. Connecting pipe; 4. Cleaning and drying module; 41. Connector; 42. Disinfectant storage chamber; 421. Water pump; 43. Drying chamber; 44. Three-way control valve; 45. Drying module; 451. Air pump; 452. Gas pipe; 453. Gas heater. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0021] The inventors discovered that the root cause affecting the efficacy and stability of nebulization is not solely the spray intensity, but also whether droplet classification and recovery are completed locally, whether the medication delivery is close to the mixing zone and can be independently routed, and whether the flow path has in-machine closed-loop sterilization and drying capabilities. If the particle size can be directly selected within the mixing zone and large droplets can be returned along the wall to the storage side, while multiple medications are arranged circumferentially close to each other to shorten the dead space, coupled with a linked cleaning-drying process, nebulization particle size, dosage switching, and infection control can be optimized simultaneously. However, existing solutions often guide the return flow back to the distal medication cup, resulting in a long path, a large dead space, and residual liquid; multiple medication paths are usually achieved through external parallel pipes or medication cup replacement, which is slow and prone to cross-contamination; cleaning and drying rely on external processing, making it difficult to link with the gas path, thus limiting turnover efficiency and safety.

[0022] Based on the above findings, this application proposes a multifunctional nebulized drug delivery device for organ transplant patients. Based on these findings, the device achieves a comprehensive technical effect by: coaxially arranging inner and outer Venturi mixing chambers within the housing, with micron-sized mesh at the upper end of the inner chamber for real-time droplet sieving; arranging an annular drug storage tank and multiple independent liquid storage tanks, along with solenoid valves and nozzles circumferentially close to the mixing section to enable selective or sequential drug delivery and on-site recirculation; integrating an internal cleaning and drying circuit consisting of a bottom three-way control valve, water pump, air pump, and gas heater; and one-button liquid drainage via a terminal pressure regulating valve. This results in concentrated droplet size and high utilization rate, rapid and non-interfering drug path switching, one-button disinfection and drying of the entire device, and compliance with high-standard hospital infection control requirements for transplant patients.

[0023] Example 1: See Figures 1-16 This application discloses a multifunctional nebulized drug delivery device for organ transplant patients, including a patient-end drug delivery module 1. The patient-end drug delivery module 1 is located at the proximal end of the device and is used to stably and selectively deliver the oxygenated drug mist output from the mixed oxygen supply module 2 to the patient. It includes a main airway 11, a three-way interface 112, a nasal cannula 12, a mouthpiece 13, and an adjustable pressure valve 111 arranged between the distal end of the main airway 11 and the mixed oxygen supply module 2.

[0024] Preferably, the patient-side drug delivery module 1 is a continuous gas path: the outlet of the mixed oxygen supply module 2 is directly connected to the main gas path 11 via the adjustable pressure valve 111. The adjustable pressure valve 111 is a small, integrated structure with an external knob or ring dial. The adjustable pressure valve 111 is connected to the outlet and the main gas path using a Luer lock or bayonet quick-connect with a sealing ring to ensure visibility, detachability, and airtightness. The main gas path 11 is a flexible, transparent round tube that can be placed in a way that is easy to observe condensation. The preferred material is medical-grade silicone or TPU. One end of the main gas path 11 is connected to the adjustable pressure valve 111, and the other end is connected to the three-way interface 112. The connector has a smooth transition and a backstop shoulder. After insertion, a stable seal is formed by the buckle, the lock, and the O-ring. Preferably, a T-shaped three-way connector 112 is compactly assembled at the proximal end of the main airway. The two branches of the three-way connector 112 are respectively connected to the nasal cannula 12 and the mouthpiece 13. Both use a unified standard connector. When in use, one branch is selected for drug delivery, and the unselected branch closes naturally with a self-sealing cap or an internal check valve. A one-way valve and a micro filter can be integrated into the end of the exhalation side to direct the exhaled air out without backflow into the main airway. Preferably, the nasal cannula 12 is a soft part that is bifurcated to conform to the curvature of the nasal cavity. The main body and the contact end are made of medical silicone or TPE. The surface micro-texture increases friction to ensure a stable fit. The connection between the nasal cannula 12 body and the three-way valve is covered with a flexible ring to improve comfort and seal. Preferably, the mouthpiece 13 is a soft-hard composite with an elliptical cross-section, with a circumferential soft skirt that fits the lips, an internal biting wing or a lightweight skeleton to prevent bite collapse, and the material is mainly TPE and silicone, which are integrated with the rigid insert. The insert and the tee are connected by a barbed mouthpiece or a Luer cone with a strap to achieve quick replacement.

[0025] Preferably, the mixed oxygen supply module 2 is composed of a hollow shell 21, a gas-liquid mixing component 22, and an oxygen supply component 23. The hollow shell 21 is an elliptical three-dimensional cavity with a hollow interior and through holes on the upper and lower sides of the middle for positioning, sealing, and communication with the gas-liquid mixing component 22. The hollow shell 21 is integrally formed with six elliptical cavities 211 with a height lower than the shell body along its circumference. Each cavity 211 has an elastic sealing element 2111 pressed into its upper opening for vertical insertion of the medicine bottle 31 to achieve self-sealing and puncture for liquid extraction. The lower end has a through hole for the balance rod 331 to pass through. The hollow shell is preferably made of transparent or semi-transparent engineering plastic to allow observation of the internal flow.

[0026] Preferably, the gas-liquid mixing assembly 22 is arranged coaxially in the middle of the hollow shell 21, and includes an inner Venturi mixing chamber 221, an outer Venturi mixing chamber 222, and micron-sized mesh 223 located thereon. The height of the inner Venturi mixing chamber 221 is approximately half the height of the shell, and it is composed of a first cylindrical shell 2211 and an inner Venturi mixing tube 2212 fixed inside it. The lower end of the first cylindrical shell 2211 passes through the bottom through hole of the shell and is sealed and fixed to the shell by means of a bayonet, threaded O-ring. The outer Venturi mixing chamber 222 is slightly smaller. It is higher than the hollow shell 21, its bottom surface is connected to the bottom of the hollow shell 21, and its upper end extends through and out of the top surface of the hollow shell 21. It includes a second cylindrical shell 2221 and an outer Venturi mixing tube 2222. The second cylindrical shell 2221 is sleeved outside the inner Venturi mixing chamber 221. The outer wall of the second cylindrical shell 2221 is sealed to the lower inner surface of the hollow shell 21 and the upper through hole, and extends to the upper surface of the shell. Its proximal end is provided with an adjustable pressure valve 111 and is connected to the main gas passage 11 through the valve to form an upstream pressure stabilizing inlet. Preferably, an outer Venturi mixing tube 2222 is provided in the upper part of the second cylindrical shell 2221. The tube and the inner Venturi mixing tube 2212 form an annular mixing section 2224 on the inner side of the second cylindrical shell 2221. Six nozzles 2223 are evenly distributed around the circumference of the mixing section and are arranged tangentially or obliquely relative to the circumference to introduce swirling flow. The nozzles 2223 are connected to the drug supply branch where the circumferential accommodating cavity 211 is located, so that the drug liquid of the selected channel is drawn into the mixing section 2224 under the action of external oxygen flow negative pressure. Preferably, a micron-sized mesh 223 is horizontally arranged at the upper end of the inner Venturi mixing chamber 221 to form a particle size sieving interface. Fine droplets pass through the mesh and rise with the airflow into the patient end, while larger droplets are blocked by the mesh and form a liquid film along the inner wall of the outer Venturi mixing chamber 222 under the action of aerodynamics and gravity. The liquid film then flows to the liquid storage tank 322 through the through hole opened on the bottom side wall of the second cylindrical shell 2221.

[0027] The oxygen supply assembly 23 includes a gas cylinder 231, a power unit 232, and a gas delivery pipe 233 connected to it. The gas cylinder 231 can be a portable high-pressure oxygen cylinder or a small liquid oxygen cylinder. A pressure reducing valve, a safety valve, and a pressure gauge are sequentially installed at the cylinder opening to stably reduce the pressure of the high-pressure gas inside the cylinder to the working pressure range. The power unit 232 is a combination of a pressure reducing valve and a constant flow valve, used to reduce the pressure of the high-pressure oxygen in the gas cylinder 231 and output it stably, driving the oxygen to be delivered upward through the gas delivery pipe 233. One end of the power unit 232 is connected to the gas cylinder 231 through the gas delivery pipe 233, and the other end is connected to the bottom of the cleaning and drying module 4 through the gas delivery pipe 233, extending through and to the bottom of the gas-liquid mixing assembly 22, directionally introducing a stable oxygen flow into the inner Venturi mixing tube 2212.

[0028] Preferably, the drug supply module 3 is arranged coaxially around the second cylindrical shell 2221 of the mixed oxygen supply module 2. An integrated annular drug storage tank 321 is fixedly sleeved on the outer wall of the second cylindrical shell 2221. The annular body independently forms six isolated liquid storage tanks 322, which are matched one by one with the six accommodating cavities 211 corresponding to the circumference of the hollow shell 21. The six medicine bottles 31 are respectively inserted into the corresponding accommodating cavities 211 of the hollow shell 21 from top to bottom. The bottle mouth is positioned and sealed by the elastic sealing member 2111 at the top of the accommodating cavity, and the bottle bottom through hole and the lower support part cooperate to form a liquid intake and gas return passage.

[0029] Preferably, the annular storage tank 321, which is fixed integrally to the outer wall of the second cylindrical shell 2221, is arranged in a ring shape, and six independent storage tanks 322 are formed along its circumference. The upper sidewall of each storage tank is connected to the corresponding nozzle 2223 through a short-distance channel. The nozzle is arranged facing the mixing section 2224 of the outer Venturi mixing chamber 222. Under the negative pressure and shearing action induced by the main oxygen flow, the liquid in the tank is stretched into a finer water column and enters the mixing zone. A miniature solenoid valve 323 is vertically installed on the top of each storage tank. The valve body and the tank opening are tightly connected by threads or snaps + sealing rings. The solenoid valve is controlled to open and close the corresponding passage of the nozzle, thereby realizing the selective or sequential switching of the six channels of medicine. In order to maintain the pressure balance inside and outside the bottle and complete the liquid delivery, a gas channel balance drug delivery component 33 is set.

[0030] Preferably, the airway balanced drug delivery assembly 33 includes a balance bar 331, a liquid collection tank 332, a balanced airway 333, and a connecting pipe 334. The balance bar 331 is L-shaped, with a slender, hollow balance bar 331 entering the medicine bottle 31 through a hole at the bottom and connecting to the area adjacent to the bottom of the bottle. Its other end is connected to the inner Venturi mixing tube via the connecting pipe 334. A through balanced airway 333 is formed inside the balance bar for introducing or releasing balanced gas. A liquid collection tank 332 is also provided inside the balance bar. One end of the liquid collection tank is connected to the bottom of the medicine bottle, and the other end is connected to the corresponding liquid storage tank 322 to introduce the drug liquid into the annular drug storage tank 321. Preferably, the connecting pipe 334 is fixedly connected to the end of the balance airway 333. It forms a gap fit with the opening of the shell at the bottom side wall of the second cylindrical shell 2221. The atomized liquid falling back along the outer wall of the second cylindrical shell 2221 is naturally drawn into the return channel in the ring and returned to the corresponding liquid storage tank 322, thus constructing a closed loop of "large droplet separation - side wall return - re-entry into the storage tank - re-spraying".

[0031] Preferably, the cleaning and drying module 4 is assembled in the middle of the mixed oxygen supply module 2, and its components include a disc-shaped connector 41, a disinfectant storage chamber 42 and a drying chamber 43 disposed in the connector 41, and a three-way control valve 44 that connects the two chambers and communicates with the upward gas supply pipe 233.

[0032] Preferably, the connector 41 has a through hole in the center, the gas supply pipe 233 passes through the through hole from bottom to top and is positioned by a sealing ring at the through hole, and the pipe end is sealed and connected to the common port of the three-way control valve 44, so that after the valve position is switched, the medium from different chambers can be uniformly sent into the upstream gas-liquid mixing component 22. Preferably, the disinfectant storage chamber 42 is designed as a closed structure, and a corrosion-resistant submersible water pump 421 is arranged inside the chamber. A washable filter and an anti-dry-running liquid level switch are installed near the pump's suction port. The pressure outlet is connected to the disinfectant port of the three-way control valve 44 through a drug-resistant hose, and a one-way valve and a flow restrictor are connected in series in the outlet section to prevent backflow and facilitate flow stabilization.

[0033] Preferably, a drying assembly 45 is integrally installed inside the drying chamber 43, which consists of an air pump 451, an air pipe 452 and a gas heater 453 connected in series. The air pump 451 is fixed on the chamber support and draws in air from outside the chamber through a filter port. One end of the air pipe 452 is connected to the air pump, and the other end is connected in series with the gas heater 453 and then connected to the heating gas inlet of the three-way control valve 44. The valve body is a small rotary or direct-acting three-way valve and corresponds to the three ports of the air supply pipe 233, the disinfectant storage chamber 42 and the heating gas passage respectively.

[0034] During operation, in disinfection mode, the three-way control valve 44 is switched to the disinfectant passage, and the water pump 421 pushes the disinfectant upward along the gas supply pipe 233, through the gas-liquid mixing component 22 and the main gas path 11 to the patient end; at this time, the adjustable pressure valve 111 is switched to the drain position / pressure relief position, and its built-in pressure relief port is opened. The liquid at the end is guided into the waste liquid container through the drain hose connected to the pressure relief port, so as to be discharged from the end through the pressure regulating valve; when switching back to drying mode, the pressure valve 111 is reset and the pressure relief port is closed, and the air pump 451 and the heater 443 output dry hot air to complete the drying, and the check device ensures that the drained liquid does not flow back into the gas path.

[0035] A procedure for using a multifunctional nebulizer for organ transplant patients includes the following steps: 1. Assembly and Connection Insert the six medicine bottles 31 into the circumferential accommodating cavity 211 of the hollow shell 21, press the bottle mouth tightly against the upper sealing gasket, and align the bottle bottom with the through hole of the support seat; insert the balance rod 331 through the bottom hole of the bottle and ensure that the liquid dispensing tank 332 and the balance airway 333 are unobstructed. After the annular medicine storage tank 321 is coaxially fixed with the second cylindrical shell 2221, confirm that each liquid storage tank 332 is connected to the corresponding nozzle and that the plug of the solenoid valve 323 is aligned. Connect the mixed oxygen supply module 2 to the patient-end drug delivery module 1, and adjust the pressure to the prescribed range through the adjustable pressure valve 111.

[0036] 2. Select the route of administration Choose "nasal inhalation" or "oral inhalation" according to the patient's condition and wear it securely; keep unused branches closed; if filtration is required, attach a disposable filter to the end.

[0037] 3. Start nebulized drug delivery Turn on the oxygen source and select the first drug delivery channel: open the solenoid valve 323 on the top of the corresponding storage tank 322; the nozzle 2223 is pulled by the venturi negative pressure, pulling the drug liquid in the tank into a fine beam and spraying it into the mixing section to mix and atomize with the oxygen flow.

[0038] Micron-sized mesh 223 sieves the droplet size, and the fine mist enters the main airway and is output to the patient; larger droplets flow back along the inner wall of the outer Venturi mixing chamber 222 and are introduced into the storage tank 322 for recycling through the gap.

[0039] Multiple drug and sequential dosing options are available. After finishing the previous medication, close its solenoid valve 323, and open the solenoid valve 323 of the next reservoir 322 as prescribed by the doctor; there is no need to disconnect the pipes between the two lines, and a seamless switch can be completed by maintaining stable pressure.

[0040] If only oxygen is needed, simply close all solenoid valves 323.

[0041] 4. End of treatment and drainage Turn off the oxygen source or turn the adjustable pressure valve 111 to the drain / pressure relief position to allow the residual liquid at the end to be discharged to the waste liquid container through the pressure relief port of the valve body; then reset the valve to the closed position.

[0042] 5. Cleaning and disinfection cycle Turn the three-way control valve 44 to the disinfection position and turn on the water pump 421 in the disinfectant storage chamber 42; the disinfectant flows upward through the air supply pipe 233, sequentially rinsing the inner / outer venturi, nozzle 2223, and main air passage 11 to the end. After cycling several times according to the program, keep the drain passage open to completely drain the rinsing solution.

[0043] 6. Drying cycle Switch the three-way control valve 44 to the drying position, start the air pump 451 and turn on the gas heater; the warm gas rises along the same path, carrying away the residual moisture and condensation.

[0044] After drying is completed, the three-way control valve 44 returns to the working position, and the air pump 451 and gas heater 453 stop.

[0045] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A multifunctional nebulized drug delivery device for organ transplant patients, characterized in that, include: The patient-end drug delivery module (1), located at the proximal end, is used to deliver oxygenated drug mist to the patient; The mixed oxygen supply module (2) is connected to the gas path of the patient-end drug delivery module (1) and is used to inhale and atomize the drug solution under the action of oxygen flow; The drug supply module (3) is located inside the mixed oxygen supply module (2), with its middle and bottom connected to the mixed oxygen supply module (2) to realize the recycling of the drug solution; The cleaning and drying module (4) is installed in the middle of the mixed oxygen supply module (2) and connected to the patient-end drug delivery module (1).

2. The multifunctional nebulized drug delivery device for organ transplant patients according to claim 1, characterized in that, The patient-side drug delivery module (1) includes: a main airway (11), a three-way interface (112) at the proximal end of the main airway, the three-way interface (112) being detachably connected to the nasal cannula (12) and the mouthpiece (13) respectively, and an adjustable pressure valve (111) between the distal end of the main airway (11) and the mixed oxygen supply module (2).

3. The multifunctional nebulized drug delivery device for organ transplant patients according to claim 1, characterized in that, The mixed oxygen supply module (2) includes: A hollow shell (21) has multiple accommodating cavities (211) spaced apart circumferentially. The gas-liquid mixing assembly (22) is located in the middle of the hollow shell (21), and its end is connected to the main gas passage (11) through an adjustable pressure valve (111); The oxygen supply component (23) is connected to the other end of the gas-liquid mixing component (22) through the cleaning and drying module (4).

4. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 3, characterized in that, The gas-liquid mixing assembly (22) includes: The inner Venturi mixing chamber (221) is located in the middle of the hollow shell (21); The outer Venturi mixing cavity (222) is coaxially sleeved outside the inner Venturi mixing cavity (221) to form an annular mixing zone; Micron-sized mesh (223) is set at the upper end of the inner Venturi mixing chamber (221) to screen the atomized liquid carried out by the inner Venturi mixing chamber (221) by particle size.

5. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 1, characterized in that, The drug supply module (3) includes: Medicine bottles (31), multiple medicine bottles (31) are respectively arranged in each receiving cavity (211); The drug storage component (32) is arranged circumferentially around the outer Venturi mixing chamber (222), with one end connected to the drug bottle (31) and the other end connected to the outer Venturi mixing chamber (222), forming several independent drug delivery channels; The balanced delivery assembly (33) is connected at one end to the medicine bottle (31) and at the other end to the Venturi mixing chamber (221) inside the storage to maintain the pressure balance inside and outside the medicine bottle (31).

6. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 5, characterized in that, The drug storage component (32) includes: An annular storage tank (321) is located outside the outer Venturi mixing chamber (222); The liquid storage tank (322) has multiple independent openings along the circumference of the annular medicine storage tank (321); A solenoid valve (323) is installed on the upper part of the liquid storage tank (322) to selectively connect the corresponding liquid storage tank (322) to the Venturi mixing chamber (222).

7. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 5, characterized in that, The airway balanced drug delivery component (33) includes: A balance bar (331) has one end connected to a medicine bottle (31) and the other end connected to an inner Venturi mixing chamber (221); The liquid collection tank (332) is located inside the balance bar (331) and is connected to the liquid storage tank (322) corresponding to the medicine bottle (31).

8. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 7, characterized in that, A balance air passage (333) is formed inside the balance bar (331). The balance air passage (333) is connected to the outer Venturi mixing chamber (222) and the inner Venturi mixing chamber (221) through the connecting pipe (334). The connection between the connecting pipe (334) and the outer Venturi mixing chamber (222) is a clearance fit to form a micro-release to recover the atomizing liquid.

9. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 1, characterized in that, The cleaning and drying module (4) includes a connector (41), which has a through hole in the middle. An air supply pipe (233) passes through the hole and communicates with the bottom of the gas-liquid mixing component (22). Inside the connector (41) and isolated from each other, there are a disinfectant storage chamber (42) and a drying chamber (43), and a three-way control valve (44) is provided between the two chambers.

10. A multifunctional nebulized drug delivery device for organ transplant patients according to claim 9, characterized in that, The drying chamber (43) is equipped with a drying assembly (45), which includes an air pump (451), a gas heater (453), and an air pipe (452) that connects the two in series to a three-way control valve (44).

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