Micro sample injector

Abstract

The invention relates to the technical field of experimental instruments, and particularly discloses a trace sample injector. Comprising a sample injector body, a vertical warning device is arranged on the sample injector body, the internal space of the vertical warning device is divided into a first accommodating cavity and a second accommodating cavity by an isolating part, and conductive liquid, a power supply, an acousto-optic device, a first electrode and a second electrode are arranged in the first accommodating cavity and the second accommodating cavity, the first electrode, the power supply, the acousto-optic device and the second electrode are connected through wires. The anti-backflow reminding device can be suitable for various pipettes which are used at present without changing the internal structure of the pipette body, and the anti-backflow reminding effect on the pipettes is achieved. By means of the technical scheme, backflow of liquid in the suction head can be effectively reduced, so that corrosion of the liquid to core components in the sample injector is avoided, the risk of cross contamination between different detection samples is reduced, and the safety and reliability of the detection process are improved.

Description

Technical Field

[0001] This invention relates to the field of laboratory equipment technology, specifically to a micro-pipette. Background Technology

[0002] A micropipette, also known as a micropipette or micropipette, is a measuring instrument used to quantitatively aspirate and transfer liquid from one container to another within a predetermined volume range. It is widely used in research and industrial laboratories in fields such as biology, chemistry, medicine, molecular biology, and pharmaceuticals. In modern biomedical basic research and clinical applications, the handling of micro-volume liquids, such as the measurement, mixing, and separation of samples and reagents, is an indispensable basic experimental step. Especially in fields such as molecular biology, biochemistry, drug development, and clinical diagnostics, experimental results require high accuracy and repeatability of the sample volume. Micropipettes have become a commonly used instrument for achieving quantitative liquid handling. Existing micropipettes typically operate based on the principle of air displacement. By pressing and releasing the piston assembly, the volume of the air chamber inside the pipette changes, creating negative or positive pressure within the pipette tip, thus achieving liquid aspiration and dispensing. By adjusting the piston's stroke length, the volume of liquid transferred can be set within a certain range.

[0003] In current clinical or research practice, micropipettes are frequently forgotten to be returned to their holders after use. When a micropipette is laid horizontally or tilted for a period of time, liquid can easily flow back into the tip, corroding the core components inside the pipette and causing cross-contamination between samples. To prevent backflow, existing technologies incorporate anti-backflow mechanisms into the infusion tubing. For example, patent application number 202110689051X discloses a device to prevent backflow into the pipette body. This device has a first connecting tube and an anti-backflow mechanism at the bottom of the main body. The anti-backflow mechanism includes a baffle and a spring, which compresses the first connecting tube to ensure unidirectional liquid flow. Another example is a backflow-preventing pipette disclosed in patent application number 2025113612305, which uses a valve core that is only activated during aspiration and dispensing to prevent backflow. Existing technical solutions, whether using flexible anti-backflow baffles or anti-backflow valve cores, require improvements to the pipette's structure and cannot provide anti-backflow protection for existing pipettes already in use. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by providing a micro-pipette.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] A micro-pipette includes a pipette body and a vertical alarm device on the pipette body. The space inside the vertical alarm device is divided into a first receiving cavity and a second receiving cavity by an isolation component. The first receiving cavity and the second receiving cavity are provided with a conductive liquid, a power supply, an acoustic and optical device, and a first electrode and a second electrode that are independent of each other. The first electrode, the power supply, the acoustic and optical device, and the second electrode are connected by a wire.

[0007] In the structure of the micro-pipette described above, the power supply and the acoustic-optical device are further disposed in the first receiving cavity, the conductive liquid is disposed in the second receiving cavity, and one end of the first electrode and the second electrode respectively penetrate the isolation component and extend into the second receiving cavity.

[0008] In the structure of the micropipette described above, when the micropipette is placed vertically, the conductive liquid in the second receiving chamber does not contact the first electrode and the second electrode. When the micropipette is placed horizontally or tilted and flipped, the conductive liquid in the second receiving chamber contacts the first electrode and the second electrode.

[0009] With the micropipette employing the above structure, when the micropipette is placed vertically, the first and second electrodes are isolated and disconnected, and the audible and visual device will not issue an alarm signal when powered off. When the micropipette is placed horizontally or tilted, due to the conductivity of the conductive liquid, the first and second electrodes become connected and conductive. At this time, the first electrode, power supply, audible and visual device, and second electrode form a current loop. After the audible and visual device is powered on, it emits an alarm light or sound signal to prompt the user to place the pipette vertically back into the pipette holder.

[0010] In the structure of the micro-pipette described above, the audible and visual device can be any one or more of a buzzer, an alarm light, or a micro vibration motor.

[0011] In the structure of the micro-pipette described above, the isolation component further includes a waterproof layer.

[0012] In the structure of the micro-pipette described above, the isolation component further includes an isolation layer.

[0013] Furthermore, in the structure of the aforementioned micro-pipette, a switch is provided on the outer casing of the alarm device.

[0014] As a further improvement to the micro-sampler of the present invention, a flow limiting plate is provided between the two electrodes and the conductive liquid in the second receiving cavity, and at least two drainage holes are provided on the flow limiting plate.

[0015] The micropipette with the above structure uses a flow limiting plate to limit the flow, which can reduce the risk of the vertical alarm device emitting a false alarm signal due to temporary tilting or flipping of the micropipette.

[0016] In the structure of the micro-pipette described above, the vertical warning device is either fixedly connected to or detachably connected to the pipette body.

[0017] In the structure of the micro-pipette described above, the vertical alarm device further includes a detachable adhesive component. The back of the adhesive component is provided with pressure-sensitive adhesive, and the front of the adhesive component is provided with a guide groove. The vertical alarm device is provided with an directional protrusion at a position corresponding to the guide groove, and the directional protrusion cooperates with the guide groove.

[0018] This invention requires no modification to the internal structure of the pipette body and is applicable to all existing pipettes, providing a backflow prevention reminder. Through this invention, backflow of liquid within the pipette tip is effectively reduced, thereby preventing corrosion of the core components inside the pipette, reducing the risk of cross-contamination between different samples, and improving the safety and reliability of the testing process. Attached Figure Description

[0019] Appendix Figure 1a This is a three-dimensional structural diagram of the micro-sampler of the present invention.

[0020] Appendix Figure 1b This is a front structural diagram of the micro-sampler of the present invention.

[0021] Appendix Figure 2 This is a schematic diagram of the vertical warning device in this invention.

[0022] Appendix Figure 3 for Figure 2 The diagram shows a cross-sectional view of the structure along the A-A' direction.

[0023] Appendix Figure 4 A schematic diagram of the internal structure of the first receiving cavity in this invention.

[0024] Appendix Figure 5 A schematic diagram of the internal structure of the second receiving cavity in this invention.

[0025] Appendix Figure 6 A schematic diagram of the improved structure of the present invention.

[0026] Appendix Figure 7 This is a schematic diagram of the connection structure between the vertical warning device and the sampler body in this invention.

[0027] The correspondence between the reference numerals and structural components in the above figures is as follows: 1. Sampler body; 2. Vertical alarm device; 3. Alarm device housing; 4. Waterproof layer; 5. Isolation layer; 6. Circuit board layer; 7. First receiving cavity; 8. Second receiving cavity; 9. Power supply; 10. Buzzer; 11. Alarm light; 12. First electrode; 13. Second electrode; 14. Conductive liquid; 15. Flow limiting plate; 16. Drainage hole; 17. Adhesive component; 18. Guide groove; 19. Orientation protrusion. Detailed Implementation

[0028] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Furthermore, it should be understood that after reading the description of this invention, those skilled in the art can make various alterations or modifications to the invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0029] Example

[0030] As shown in Figure 1, attached Figure 1a This is a three-dimensional structural schematic diagram of the micro-sampler of the present invention, with attached... Figure 1b This is a front structural diagram of the micropipette of the present invention. The present invention provides a micropipette, including a pipette body 1 and a vertical warning device 2 disposed on the surface of the pipette body. When the micropipette is placed horizontally or tilted and flipped, the vertical warning device actively emits an alarm sound or an alarm light to remind the user that the pipette needs to be placed vertically back into the pipette holder.

[0031] Figure 2 This is a schematic diagram of the vertical warning device in this invention. Figure 3 This is a cross-sectional diagram of the vertical warning device structure along the A-A' direction. (Example) Figure 2 and Figure 3 As shown, the vertical warning device includes a warning device housing 3, and the space inside the warning device housing is divided into a first receiving cavity 7 and a second receiving cavity 8 by an isolation component. Figure 4 As shown, a circuit board layer 6 is provided inside the first receiving cavity. A power supply 9, an audio-visual device, and independent first and second electrodes are provided on the circuit board layer. The first electrode, power supply, audio-visual device, and second electrode are connected by wires. Figure 3-5 As shown, the attached Figure 5 This is a schematic diagram of the internal structure of the second receiving cavity in this invention. One end of the first electrode and the second electrode respectively penetrate the isolation component and extend into the second receiving cavity. A flowable conductive liquid is provided in the second receiving cavity.

[0032] The technical solution of the above embodiment features a vertical alarm device on the surface of the micropipette body. A power supply and an audible-optical device are housed in the first receiving cavity of the vertical alarm device, while a conductive liquid is placed in the second receiving cavity. One end of the first electrode and the second electrode are located in the second receiving cavity, and the other end passes through an isolation component and is electrically connected to the power supply and the audible-optical device. When the micropipette is placed vertically, the conductive liquid in the second receiving cavity does not contact the first and second electrodes, and the first and second electrodes are in an isolated, disconnected state. At this time, the audible-optical device will not issue an alarm signal when powered off. When the micropipette is placed horizontally or tilted, the conductive liquid in the second receiving cavity contacts the first and second electrodes. Due to the conductivity of the conductive liquid, the first and second electrodes become electrically connected. At this time, the first electrode, power supply, audible-optical device, and second electrode form a current loop. After the audible-optical device is powered on, it emits an alarm light or sound signal, prompting the user to vertically return the pipette to the pipette holder.

[0033] In some embodiments of the present invention, the sound and light device is a buzzer 10 or an alarm light 11. Figure 4 The audible and visual device is illustrated as a buzzer 10 and an alarm light 11. In another specific embodiment, for the purpose of warning, the audible and visual device may be either a buzzer or an alarm light, or it may be any other known prior art device that can warn a user, such as a miniature vibration motor.

[0034] In some embodiments of the present invention, the warning device housing is further provided with a switch, which is connected to a power source. The conductive liquid may be water or other conductive liquids.

[0035] In some embodiments of the present invention, the isolation component is a waterproof layer 4, which is made of silicone, rubber, TPE, or TPU material, and the outer edge of the waterproof layer is sealed to the outer shell of the warning device. To better support the waterproof layer and improve the waterproof isolation effect, the isolation component further includes an isolation layer 5, which is made of polycarbonate or a rigid polymer material, and provides structural support for the waterproof layer and restricts its deformation.

[0036] To reduce the risk of false alarms from the vertical alarm device due to temporary tilting or flipping of the micropipette, the structure within the second receiving cavity is further improved in some embodiments of the present invention. Please refer to the appendix. Figure 6 , attached Figure 6This invention presents a schematic diagram of the internal structure of the second receiving cavity in the improved embodiment. A flow-limiting plate is provided between the two electrodes and the conductive liquid within the second receiving cavity, and at least two drainage holes are provided on the flow-limiting plate. In this embodiment, the flow-limiting plate serves to limit the flow. The conductive liquid on one side of the flow-limiting plate needs to pass through the drainage holes to reach the receiving cavity where the two electrodes are located. Due to the flow-limiting effect of the flow-limiting plate, when the micropipette is temporarily tilted or flipped, only a small amount of conductive liquid passes through the drainage holes to reach the receiving cavity where the two electrodes are located. At this time, the liquid level is insufficient to submerge the two electrodes, causing the first and second electrodes to fail to conduct electricity. Only after tilting, flipping, or lying flat for a period of time can the first and second electrodes conduct electricity under the action of sufficient conductive liquid. The advantage of setting a flow-limiting plate and flow-limiting holes between the two electrodes and the conductive liquid in the second receiving cavity is that it can reduce the false triggering signal of the vertical alarm device caused by the temporary tilting or flipping of the micropipette.

[0037] In some embodiments of the present invention, the vertical warning device is fixedly connected to the sampler body. In other embodiments of the present invention, the vertical warning device is detachably connected to the sampler body, and the detachable connection is by adhesive, snap-fit, or magnetic connection. Figure 7 A specific preferred embodiment of the connection provided by the present invention, such as Figure 7 As shown, the vertical alarm device also includes a detachable adhesive component. The back of the adhesive component is provided with pressure-sensitive adhesive, which bonds the adhesive component to the sampler body. A guide groove is provided on the front of the adhesive component, and an directional protrusion is provided at a position corresponding to the guide groove on the vertical alarm device. The directional protrusion engages with the guide groove. In use, the adhesive component is first attached to an appropriate position on the surface of the sampler body, and then the directional protrusion of the vertical alarm device is inserted into the guide groove to fix the vertical alarm device to the sampler body. In other embodiments of the invention, magnetic attraction devices are respectively provided at or near the directional protrusion and the guide groove. The magnetic attraction devices can be magnets and metal, or magnets with positive and negative charges attracting each other. These magnetic attraction devices can make the connection between the vertical alarm device and the sampler body more secure.

[0038] The above description is only a preferred embodiment of the present invention. It should be noted that those skilled in the art can make several improvements and additions without departing from the method of the present invention, and these improvements and additions should also be considered within the scope of protection of the present invention.

Claims

1. A micro-syringe comprising a syringe body, characterized in that, The vertical warning device is arranged on the pipette body, and the space inside the vertical warning device is divided into a first accommodating cavity and a second accommodating cavity by a separation component, and a conductive liquid, a power supply, an audible and light device, and first and second electrodes independent of each other are arranged in the first and second accommodating cavities, and the first electrode, the power supply, the audible and light device, and the second electrode are connected by wires.

2. The micro-sampler according to claim 1, characterized in that, The power supply and the audible and light device are arranged in the first accommodating cavity, the conductive liquid is arranged in the second accommodating cavity, and one end of the first and second electrodes respectively extends into the second accommodating cavity through the separation component.

3. The micro-sampler according to claim 2, wherein When the micropipette is vertically placed, the conductive liquid in the second accommodating cavity does not contact the first and second electrodes, and when the micropipette is placed horizontally or tilted and turned over, the conductive liquid in the second accommodating cavity contacts the first and second electrodes.

4. The micro-sampler according to claim 3, wherein The audible and light device is any one or more of a buzzer, an alarm lamp, or a micro vibration motor.

5. The micro-sampler according to claim 4, wherein The separation component comprises a waterproof layer.

6. The micro-sampler according to claim 5, wherein The separation component further comprises an isolation layer.

7. The micro-sampler according to claim 6, characterized in that A switch is arranged on the shell of the warning device.

8. The micro-sampler according to any one of claims 1 to 7, wherein A flow limiting plate is arranged between the two electrodes and the conductive liquid in the second accommodating cavity, and at least two flow guide holes are arranged on the flow limiting plate.

9. The micro-sampler according to claim 8, characterized in that The vertical warning device is fixedly connected or detachably connected with the pipette body.

10. The micro-sampler according to claim 9, characterized in that The vertical warning device further comprises a separable adhesive member, the back surface of the adhesive member is provided with a pressure-sensitive adhesive, the front surface of the adhesive member is provided with a guide groove, a directional protrusion is arranged at a position corresponding to the guide groove of the vertical warning device, and the directional protrusion is matched with the guide groove.

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