Ion release of oral care compositions and related nozzles, assemblies, and methods

Abstract

A method for using an oral care composition includes dispensing an oral care composition through a nozzle to form a dispensed composition. The nozzle includes an orifice having a central axis and an orifice diameter, and a fin partially blocking the orifice. The method further includes brushing teeth with the dispensed composition to form a slurry. The dispensed composition has faster ion release during brushing compared to a control dispensed composition prepared by dispensing the oral care composition through a control nozzle including a non-clogging circular orifice having an orifice diameter.

Description

Technical Field

[0001] This disclosure relates generally to improved ion release of oral care compositions, and more specifically to nozzles, components, and methods for dispensing oral care compositions with improved ion release. Background Technology

[0002] Oral care compositions (such as toothpaste and / or dental floss compositions) are applied to the oral cavity to clean and / or maintain the aesthetics and / or health of teeth, gums, and / or tongue. Additionally, many oral care compositions deliver active ingredients directly to the oral care surface. Using the appropriate amount of an oral care composition ensures you have the right amount of active ingredients to provide effective cleaning and remove plaque, food particles, and bacteria, thus promoting optimal oral hygiene. For example, many toothpastes contain fluoride, which helps strengthen tooth enamel and prevent cavities. Using the recommended amount of toothpaste and the recommended brushing time helps ensure the user receives an effective dose of fluoride and / or the desired amount of aesthetic ingredients (e.g., flavoring agents) for their beneficial effects.

[0003] Many commercial toothpaste packages feature a cylindrical nozzle and a flexible tube containing the toothpaste. When the user squeezes the tube, the toothpaste is extruded through the cylindrical nozzle and dispensed onto the toothbrush head in the form of granules. Users tend to apply less toothpaste than recommended. Additionally, many users brush for less time than recommended. There is a need for devices or methods to improve the delivery of the ingredients without requiring users to change their habits. Summary of the Invention

[0004] In one embodiment, a method for using an oral care composition is provided. The method includes dispensing the oral care composition through a nozzle to form a dispensed composition. The nozzle includes an orifice having a central axis and an orifice diameter, and fins that partially block the orifice. The method also includes brushing teeth with the dispensed composition to form a paste. Compared to a control-dispensed composition prepared by dispensing the oral care composition through a control nozzle including an unblocked circular orifice with an orifice diameter, this dispensed composition exhibits faster ion release during brushing.

[0005] In one embodiment, a method for using an oral care composition is provided. The method includes dispensing the oral care composition through a nozzle to form a dispensed composition. The nozzle includes an orifice having a central axis and an orifice diameter, and fins that partially block the orifice. The method also includes adding the dispensed composition to a liquid and forming a slurry of the dispensed composition and the liquid. Compared to a control-dispensed composition prepared by dispensing the oral care composition through a control nozzle including an unblocked circular orifice with an orifice diameter, this dispensed composition exhibits faster ion release in the slurry. Attached Figure Description

[0006] Although this specification concludes by specifically pointing out and clearly claiming the claims of the invention, it is believed that the invention will be better understood by the following description taken in conjunction with the accompanying drawings, wherein: Figure 1 This is a top view of an example implementation of the nozzle.

[0007] Figure 2 yes Figure 1 A perspective view of the nozzle.

[0008] Figure 3 yes Figure 1 Side view of the nozzle.

[0009] Figure 3A It is along Figure 3 The line 3A-3A is cut off. Figure 1 A cross-sectional view of the nozzle.

[0010] Figure 4 This is a perspective view of an example implementation of the nozzle.

[0011] Figure 5 yes Figure 4 A top view of the nozzle.

[0012] Figure 6 This is a perspective view of an example implementation of the nozzle.

[0013] Figure 7 yes Figure 6 A top view of the nozzle.

[0014] Figure 8 This is a perspective view of an example implementation of a flip-top cover.

[0015] Figure 9 This is a perspective view of an example implementation of the pipe.

[0016] Figure 10 This is a graph showing the percentage of theoretical fluoride ions released into the solution over time during the mixing of dental cleaning agents extruded through a comparative nozzle and the nozzle of the present invention.

[0017] Figure 11 It is shown Figure 10 The graph shows the area under the curve (AUC) for the first 30 seconds of the results.

[0018] Figure 12 This is a graph showing the theoretical percentage of ion release over time for the comparative nozzle and the nozzle of the present invention.

[0019] Figure 13 It is shown Figure 12 A graph showing the numerical difference in the theoretical ion release percentage over time.

[0020] Figure 14 It is shown Figure 12 A graph showing the rate of change of the theoretical ion release percentage over time.

[0021] Figure 15 This is a graph comparing the AUC at 30 seconds with the clogging area of ​​the comparative nozzle and various nozzles of the present invention.

[0022] Figures 16A to 16E These are the perspective view, side view, sectional view, top view, and bottom view of the nozzle.

[0023] Figures 17A to 17E These are the perspective view, side view, sectional view, top view, and bottom view of the nozzle.

[0024] Figures 18A to 18E These are, respectively, a perspective view, a side view, a sectional view, a top view, and a bottom view of the nozzle of the present invention.

[0025] Figures 19A to 19E These are, respectively, a perspective view, a side view, a sectional view, a top view, and a bottom view of the nozzle of the present invention.

[0026] Figure 20 It is a comparison Figure 16A , Figure 17A , Figure 18A and Figure 19A A graph showing the average fluoride ion release from the nozzle over 30 seconds.

[0027] Figure 21 This is a graph showing the theoretical percentage of fluoride ions released from three dental cleaning agents into the solution over time for both the comparative nozzle and the nozzle of the present invention.

[0028] Figure 22 This is a graph showing the theoretical percentage of fluoride ions released from three dental cleaning agents after 30 seconds for the nozzle of the present invention.

[0029] Figure 23 This is a graph showing the mV measurements of the slurry over time during mixing of dental cleaning agents extruded through a comparative nozzle and the nozzle of the present invention.

[0030] Figure 24 This is a graph showing the percentage change of mV over time during the mixing of dental cleaning agents extruded through a comparative nozzle and the nozzle of the present invention.

[0031] Figure 25 This is a graph showing the pH over time during the mixing of dental cleaning agents extruded through a comparative nozzle and the nozzle of the present invention. Detailed Implementation

[0032] Embodiments of the present invention relate to a partially clogged nozzle that provides improved paste weight during use. The nozzle may also provide the user with an improved aesthetic experience, an improved sensory experience, and an improved rate of release of ingredients or ions from the dispensed oral care composition. Embodiments of the present invention also relate to oral care assemblies comprising a nozzle and a tube, and methods of manufacturing and using such assemblies.

[0033] It has been found that the shape of the nozzle orifice affects toothpaste pellet output in a variety of ways. Changing how the oral care composition exits the tube has a significant impact on both the physical pellets and the consumer's sensory experience. For example, creating multiple individual strips that join together at the orifice to form a pellet on the toothbrush head increases the surface area of ​​the resulting pellet. This, in turn, provides aesthetic benefits by changing the pellet shape from a simple cylinder to an aesthetically pleasing vortex. Alternatively, shearing the oral care composition immediately before brushing when dispensed onto the toothbrush appears to significantly affect the sensory experience, as it improves dispersibility, increases flavor presentation, and increases foaming. Without being bound by theory, it is believed that shearing, pressure, and off-axis extrusion, whether individually or in combination, can lead to an increase in pellet weight, as discussed further below. Therefore, a nozzle according to one embodiment of the invention enhances the appearance of the pellets, increases the size and surface area of ​​the dispensed oral care composition, and positively influences the consumer's experience of dispersibility, flavor, and foaming. These changes can be aesthetically pleasing and deliver an amount of oral care composition closer to the recommended dosage. If users brush for less time than recommended, these changes can also provide an improved experience by releasing the ingredients more quickly during brushing. The improved paste properties and brushing experience are due to the interaction of the oral care composition with partially blocked pores.

[0034] Although the following detailed description is given primarily in the context of nozzles and tubes for containing dental cleaning products, it should be understood that nozzles or tubes may be used to contain and dispense other oral care or personal care products in which an increased amount of product, an improved sensory experience, or improved ion release or dissolution is expected compared to a conventional round orifice.

[0035] The following chapter titles are provided solely for organizational and convenience purposes.

[0036] definition To more clearly define the terms used herein, the following definitions are provided. Unless otherwise indicated, the following definitions apply to this disclosure. If a term is used in this disclosure but is not specifically defined herein, the definition from IUPAC Compendium of Chemical Terminology, 2nd Edition (1997) may be applied, provided that the definition does not conflict with any other disclosure or definition applied herein, or render any claim to which the definition is applied uncertain or unenforceable.

[0037] As used herein, “connection” means “permanent connection” or “releasable connection”. The term “permanent connection” is understood to mean a configuration in which a first element is fixed to a second element such that the elements cannot normally be separated from each other without at least partially damaging one or both elements. The term “releasable connection” is understood to mean a configuration in which a first element is fixed to a second element such that the first element and the second element can be separated without damage or with minimal damage to the first element and the second element.

[0038] As used herein, the term "oral care composition" includes products that are not intended for systemic administration of a particular therapeutic agent during ordinary use, but rather to remain in the oral cavity for a sufficient duration to contact the tooth surface or oral tissues. Examples of oral care compositions include dental floss, toothpaste, teething gel, subgingival gel, lotion, mouthwash, mousse, foam, oral spray, lozenges, chewing tablets, chewing gum, teeth whitening strips, dental floss and floss coatings, breath freshening soluble strips, unit-dose compositions, fiber compositions, or denture care or adhesive products. Oral care compositions may also be incorporated into strips or films for direct application or attachment to oral surfaces (such as teeth whitening strips). Examples of lotion compositions include the lotion composition of U.S. Patent No. 11,147,753, and clogging lotions, such as the clogging oil-in-water emulsion of U.S. Patent No. 11,096,874. Examples of unit-dose compositions include the unit-dose composition of U.S. Patent Application Publication No. 2019 / 0343732.

[0039] Unless otherwise specified, as used herein, the term "dental cleaning composition" includes dental or subgingival pastes, gels, or liquid formulations. A dental cleaning composition may be a monophasic composition or a combination of two or more individual dental cleaning compositions. A dental cleaning composition may be in any desired form, such as deep streaks, light streaks, multilayers, pastes surrounded by gels, or any combination thereof. In dental cleaning compositions comprising two or more individual dental cleaning compositions, each composition may be contained in a physically separate dispenser compartment and dispensed side-by-side.

[0040] The “active ingredients and other ingredients” used herein may be categorized or described in accordance with their cosmetic and / or therapeutic benefits or their assumed mode of action or function. However, it should be understood that in some cases, the active substances and other ingredients used herein may provide more than one cosmetic and / or therapeutic benefit, or act or function via more than one mode of action. Therefore, the categorization herein is for convenience only and is not intended to limit the ingredients to the specific functions or activities listed.

[0041] As used herein, the term “substantially free” means that the composition contains no more than 0.05%, preferably no more than 0.01%, and more preferably no more than 0.001% of the specified material on a total weight basis.

[0042] As used herein, the term "substantially free of" means that the indicated material is not intentionally added to the composition, or preferably is not present at an analytically detectable level. This means a composition in which the indicated material is present only as an impurity among other intentionally added materials.

[0043] The term “oral hygiene program” or “program” can be used to describe the use of two or more separate and distinct steps of oral health care, such as toothpaste, mouthwash, dental floss, toothpicks, sprays, rinsing devices, and massagers.

[0044] Unless otherwise stated, although compositions and methods are described herein by way of “comprising” various components or steps, compositions and methods may also be “inherently composed of various components or steps” or “consisting of various components or steps”.

[0045] As used in this article, the word "or" when used as a conjunction for two or more elements means including either the element alone or a combination of the elements; for example, X or Y means X or Y or both.

[0046] As used herein, the articles “an” and “a” are understood to mean one or more of the materials protected or described in the claims, such as “oral care composition” or “bleaching agent”.

[0047] Unless otherwise specified, all measurements mentioned herein were performed at approximately 23°C (i.e., room temperature).

[0048] Several types of scopes are disclosed in respect of embodiments of the present invention. When any type of scope is disclosed or protected by claims, the purpose is to disclose or protect by claims every possible value that such scope can reasonably cover, including the endpoints of the scope and any sub-scopes and combinations thereof covered therein.

[0049] nozzle The size and shape of the nozzle help define the user's experience of dispensing the desired volume of toothpaste from the packaging. A nozzle according to one embodiment of the invention can provide several benefits. For example, it can increase the weight of the toothpaste pellet to help deliver an optimal dose of oral care composition to the user. The oral care composition can be formulated to provide specific amounts of active ingredients (e.g., fluoride) and aesthetic ingredients (e.g., for flavor or foaming). The increased weight of the toothpaste pellet due to the use of the improved nozzle can result in superior foaming and flavor presentation, which provides a pleasant brushing experience and leaves the mouth feeling clean and fresh compared to using less than the recommended amount of oral care composition. Superior foaming performance can be, for example, an increased rate of foam production during the early stages of brushing. The aesthetics of the toothpaste pellet can be improved through a swirling shape compared to conventional cylindrical pellets. Due to the improved pellet, users may experience several differences during brushing. Some examples include improved foaming properties, a lighter, more palatable, and more creamy feel to the oral care composition, and an improved rate of ingredient release into the solution, making it more likely that active and aesthetic ingredients will be fully released before the brushing event is over. Improved foaming properties can be, for example, an increased rate of foam generation during the early stages of brushing.

[0050] Figures 1 to 3A A nozzle 10 according to one embodiment of the invention is illustrated. In use, an oral care composition (such as toothpaste) is extruded through the nozzle orifice to the outside of the nozzle 10 (e.g., onto a toothbrush) to produce paste particles. The nozzle 10 may include a nozzle orifice 12 having a central axis 14. The nozzle orifice 12 may be defined by sidewalls 16. The sidewalls 16 may have a distal surface or edge 18, an inner surface 20, and an outer surface 22. The edge 18 may be in a plane orthogonal to the central axis 14 of the orifice 12. The edge 18 may be coplanar with the nozzle orifice 12. The thickness of the edge 18 may be in the range of about 0.25 mm to about 4 mm or about 0.5 mm to about 1.5 mm. The diameter of the orifice 12 may be about 8 mm, about 9 mm, about 10 mm, or about 7 mm to about 11 mm, or about 8 mm to about 10 mm, or about 8.5 mm to about 10 mm.

[0051] The nozzle orifice 12 may be partially blocked, for example, by one or more fins 24. Each fin 24 may extend from an inner end 26 to an outer end 28 and between a first side surface 30 and a second side surface 32. The fin 24 may also include an upper surface 34 and a lower surface 36. The fin 24 may be located proximal to, distal to, or in line with the orifice 12. In one embodiment, the entire upper surface 34 of the fin 24 may be located distal to the orifice 12, and the entire lower surface 36 may be located proximal to the orifice 12. In one embodiment, the upper surface 34 may be flat or arched (e.g., see...). Figure 6The lower surface 36 may be, for example, arched or flat (not shown). The fins 24 may be aligned with each other, or, for example, one or more fins of fin 24 may be located closer to or farther from another fin 24. At least a portion of the fin 24 extends above the orifice 12 to partially block the orifice 12. The fin 24 may also extend radially outward from the orifice 12. For example, the outer end 28 of the fin 24 may extend to the edge of the edge 18 of the sidewall 16. Figure 2 and Figure 3A As shown, in one embodiment, the fins 24 may extend above and below (or proximal and distal) the aperture 12.

[0052] Fin 24 creates openings 38 through which the oral care composition moves as it is extruded through nozzle 10. Openings 38 can be symmetrical or asymmetrical. Figure 4 and Figure 5 As best shown, these openings 38 may include an axial channel 40 and / or an off-axis channel 42. The axial channel 40 is a space extending distal to the nozzle orifice 12 to the distal end of the fin 24. The off-axis channel 42 corresponds to the axially outer side of the orifice 12 and extends to the outer end of the fin 24. For example, in Figure 5 In this configuration, the off-axis channel 42 extends distally from edge 18 to the top of fin 24, from the inner edge of edge 18 (orifice 12) to the outer edge of edge 18, and extends between the sides of fin 24. When the oral care composition is extruded, the composition moves through a portion of the axial channel 40 generally parallel to the central axis 14 of orifice 12 (arrow A1). Reference Figure 4 The off-axis channel 42 allows some of the extruded oral care composition to move axially away from the central axis 14 (arrow A2) of the orifice 12. Extruding the oral care composition around the fin 24 and through the off-axis channel 42 both shears and pressurizes the flow of the oral care composition. Surprisingly, shearing and pressurization have been found to result in an increase in granule weight. In particular, the product shearing and reshaping appear to enhance and amplify flavor presentation, which provides an improved consumer experience when brushing with a product extruded through this type of shaped orifice.

[0053] refer to Figure 2 and Figure 3AIn one embodiment, the nozzle 10 may include a hub 44 connecting the fins 24. In one embodiment, the hub 44 may be centered relative to the orifice 12 such that the longitudinal axis of the central hub 44 is coaxial with the central axis 14 of the orifice 12. The size and shape of the hub may vary. For example, the upper surface 46 of the hub 44 may be circular. The maximum diameter of the central hub 44 may be in the range of, for example, about 0.5 mm to about 5 mm, about 1 mm to about 4 mm, or about 2.5 mm to about 3.5 mm. The central hub 44 may have a conical shape with a lower tip 48, such as... Figure 3A Ideally, this is to guide the flow of the oral care composition and facilitate lateral extrusion. In another embodiment, the central hub 44 may be cylindrical or may have a flat lower surface. Similar to fins 24, the central hub 44 may be raised relative to the orifice 12. This height also facilitates lateral extrusion of the oral care composition during dispensing. In one example, the upper surface 46 of the central hub 44 may be located distal to the orifice 12, and the tip 48 or lower surface of the central hub 44 may be located proximal to the orifice 12. The central hub 44 may be in the same plane or a different plane from the fins 24. In another embodiment, the fins 24 may be spaced apart such that they do not contact each other (e.g., no central hub).

[0054] Several parameters, including fin width, thickness, and height relative to the orifice, have been found to affect the weight and aesthetics of the toothpaste particles. Unbound by theory, it is believed that recrystallization of the oral care composition as it is extruded by the consumer results in an increase in the effective particle diameter, which in turn increases the dosage. Given that benefits such as caries prevention, whitening, cleaning, gingivitis relief, and fresh breath can be dose-dependent, this property provides an advantage to consumers. This is particularly important when using smaller toothbrush heads (such as those found on most electric toothbrushes), where the usable surface area for dispensing the product is limited compared to most manual brush heads.

[0055] The off-axis extrusion region and the total restricted orifice area can vary. The off-axis extrusion region can be 0 mm. 2 Approximately 1cm 2 0mm 2 approximately 25mm 2 Approximately 0mm 2 Approximately 5mm 2 or approximately 3.9mm 2 Approximately 16.4mm 2 Within the range. In one embodiment where the fins are fan-shaped or disc-shaped, the off-axis extrusion area can be approximated by the product of the following: the number of fins (n), the distance by which the top of the fin protrudes distally beyond the orifice, and the approximate width (b) of the opening between the fins. The maximum width (b) of the opening between the individual fins can be approximated by the following equation: Where “r” is the radial distance from the center of the orifice to the outer circle defined by the end of the fin, “n” is the number of fins, and “a” is the fin width at the inner edge of the orifice. Figure 5 The symbols “r”, “a”, and “b” are shown in an example implementation. The off-axis extrusion region can be divided into a low-pressure region and a high-pressure region.

[0056] The total orifice surface area (e.g., limited by fins 24 and optional hub 44) may be in the range of about 10% to about 90%, about 40% to about 60%, 38.3% to about 58.9%, about 44.6% to about 49.6%, about 45% to about 50%, or about 46% to about 48% of the total orifice surface area.

[0057] The number of fins 24 can vary. The nozzle 10 may have, but is not limited to, 1 fin, 2 fins, 3 fins, 4 fins, 5 fins, 6 fins, 7 fins, or more than 7 fins. The nozzle 10 may have, but is not limited to, 1 to 10 fins, 3 to 7 fins, or 4 to 6 fins.

[0058] The length of fin 24 can vary. Fins 24 can have the same length or different lengths. Figure 1 The length L of the fin 24 is shown. In some embodiments, the length or maximum length of the fin 24 may be in the range of about 1 mm to about 7 mm, about 3.25 mm to about 4.5 mm, or about 3.5 mm to about 4 mm.

[0059] The width of fin 24 can be varied. Fins 24 can have the same width or different widths. The width of fin 24 can be constant or can vary along fin 24. The variation in fin width can be constant or variable. For example, as... Figure 1 As shown, the sides of fin 24 taper linearly inward from their maximum width W toward the central hub 44. In another example, the sides of fin 24 may be curved outward or inward. In some embodiments, the width or maximum width of fin 24 may be from about 0.5 mm to about 6 mm, from about 1 mm to about 5 mm, from about 3 mm to about 5 mm, from about 3.25 mm to about 4.5 mm, or from about 3.25 mm to about 4 mm.

[0060] The thickness of fin 24 can be varied. Fin 24 can have the same thickness or different thicknesses. The thickness of fin 24 can be constant or can vary along fin 24. For example, as Figure 3AAs shown, the thickness of the fin 24 decreases from the maximum thickness T toward the central hub 44. In some embodiments, the thickness or maximum thickness of the fin 24 may be in the range of about 0.1 mm to about 10 mm, about 0.25 mm to about 5 mm, about 0.25 mm to about 2 mm, or about 0.5 mm to about 1.5 mm.

[0061] The height of fin 24 relative to orifice 12 is variable. The height of fin 24 can be measured from the lower surface 36 of fin 24 to edge 18, or, if no edge exists, to the farthest edge of orifice 12. Figure 3A The height E of fin 24 is shown. In some embodiments, the height, or maximum height, can range from about -5 mm to about 5 mm, from about -2 mm to +1 mm, from about -1 mm to about 0 mm, from about -0.5 mm to about 0 mm, and from about 0 mm to about 0.5 mm. Reference Figure 4 and Figure 5 An example embodiment of the nozzle 10 is shown, in which the fins 24 are raised above the nozzle orifice 12.

[0062] The shape of the fin 24 can be varied. In another embodiment, the fin can have a triangular, rectangular, or curved shape, or it can be shaped like a fan blade or propeller blade. Figure 1 and Figure 5 As shown, in one embodiment, the fin 24 may be fan-shaped or disc-shaped. The fin 24 may extend from the edge 18 above the aperture 12. The fin 24 may be coupled to the central hub 44. The fin 24 and the central hub 44 may form a wheel shape. In another embodiment, the fin 24 may be arched and coupled to the central hub 44 to form a dome shape (e.g., as shown). Figure 6 (As shown). In another embodiment, fin 24 may have an end that is not connected to another portion of nozzle 10. In an embodiment excluding the edge, fin 24 may be connected to nozzle 10 adjacent to the edge of orifice 12 and extend distally to orifice 12. Fin 24 may be tilted at an angle relative to the central axis 14 of orifice 12, or may be perpendicular to the central axis 14 (e.g., as shown). Figure 2 and Figure 3A (As shown).

[0063] refer to Figure 6 and Figure 7In another embodiment, the fin 24 may be shaped similarly to a curved fan blade. For example, the fin 24 may have a longitudinal portion 50, an axial portion 52, and a transition portion 54 therebetween. The longitudinal portion 50 may be coupled to an edge 18 and extend distally from the edge 18. In an embodiment excluding the edge, the longitudinal portion 50 may be coupled to the nozzle 10 adjacent to the edge of the orifice 12 and extend distally from the orifice 12. In the illustrated embodiment, the longitudinal portion 50 does not extend above the orifice 12. In another embodiment, the longitudinal portion 50 may extend above the orifice 12.

[0064] The axial portion 52 may extend toward the central axis 14 of the orifice. In other words, the axial portion 52 may extend above the orifice 12 and partially block it. The axial portion 52 may extend to the central hub 44 (if present). In an embodiment where the central hub is absent, the end of the axial portion 52 may be freely suspended over the orifice 12, or may engage with the axial portion 52 of another fin 24. The axial portion 52 may be tilted at an angle relative to the central axis 14 of the orifice 12. The tilt angle of the axial portion 52 may vary along its length. The tilt angle may be from about 0° to about 90°, between about 0° and about 60°, between about 15° and about 90°, between about 40° and about 50°, or may be about 0° or about 45°. In another embodiment, the axial portion 52 may be perpendicular to the central axis 14 of the orifice 12.

[0065] A transition portion 54 extends between the longitudinal portion 50 and the axial portion 52. The transition portion 54 may be curved and twisted. At least a portion of the transition portion 54 may be inclined relative to the central axis 14 of the orifice 12. In various embodiments, the transition portion 54 may partially block the orifice 12 or may not block the orifice 12.

[0066] When the first side surface 30 and the second side surface 32 of the fin 24 are not coplanar, the first side surface 30 and the second side surface 32 may define a leading edge and a trailing edge, respectively. The trailing edge at the axial portion 52 may be located distal to the leading edge at the axial portion 52. When extruded through the nozzle, the oral care composition may first contact the leading edge and then the trailing edge.

[0067] The width and thickness of the longitudinal portion 50, the axial portion 52, and the transition portion 54 can vary. For example, the thickness of the transition portion at its trailing edge can be greater than the thickness of the transition portion at its leading edge. The thickness of the longitudinal portion 50 can be greater than the thickness at the end of the axial portion 52. Similarly, the width of the longitudinal portion 50 can be greater than the width at the end of the axial portion 52.

[0068] Top cover According to some implementation schemes, the nozzle can be connected to the top cover or integrated with the top cover. For example... Figure 8 As shown, in one embodiment, the top cover may be a hinged top cover 56 having a cover 58 hinged to a top cover body 60. The top cover body 60 may be configured to be releasably connected to a container or pipe.

[0069] The form of the top cap can be varied. The nozzle can serve as the top cap on the pipe. Figures 1 to 7 The example nozzle shown is depicted as having a Fiss-like skirt extending proximally from the nozzle. For example, as... Figure 3A As shown, the skirt 62 may flare slightly outward from the nozzle 10 to the proximal end of the skirt 62. The outer surface of the skirt 62 may be smooth or textured, such as ridged. The skirt may, for example, be removably connected to the tube using internal threads 64.

[0070] Alternatively, the nozzle may be separate from the top cover. For example, the nozzle may be connected to or integrated with a pipe, as discussed below. In such embodiments, the top cover may be a conventional top cover, such as a screw-on top cover (e.g., a Fiss top cover).

[0071] Tube Oral care components may include tubes, nozzles, and caps. Figure 9 An example of a reservoir or tube 66 and a nozzle, such as nozzle 10, according to an example embodiment is illustrated. Tube 66 may contain an oral care composition, such as toothpaste. The longitudinal axis of the tube or component, the central axis 14 of the orifice 12, and the flow direction of the oral care composition may, for example, be parallel or coaxial. Figure 9 As shown, nozzle 10 may be integral with or coupled to tube 66. For example, if nozzle 10 is coupled to tube 66, nozzle 10 may extend from insert 68 fixed inside tube 66. In other embodiments, nozzle 10 may be coupled to a top cover (e.g., Figure 8 The top cover 56 is integral with or connected to the top cover. When the top cover is connected to or otherwise closed with the tube 66, the tube 66 is sealed to prevent leakage of the contents of the tube under normal conditions.

[0072] The tube 66 may include a tube body 70 that can be squeezed by a user to expel the contained oral care composition through the nozzle 10. The tube body 70 may have a shoulder 72. In embodiments where the nozzle 10 is not integral with the tube 66, the tube 66 may include a tube orifice. In embodiments where the nozzle 10 is integral with the tube 66, a nozzle orifice 12 may serve as a tube orifice. When the tube is squeezed, the contents of the tube pass through the tube orifice and / or the nozzle orifice 12 to the outside of the assembly (e.g., to a toothbrush). The tube body 70 may be sealed at one end (such as the end of the tube 66 opposite the shoulder 72 or the tube orifice) by a coiled seal 74.

[0073] The tube 66 may be configured to be releasably connected to a top cover (e.g., top cover 56). For example, the tube 66 and the top cover may include corresponding threads. The top cover may include threads (e.g., Figure 3A The cap (64) is configured to releasably engage with a thread (not shown) on the tube 66. In one embodiment, the tube 66 may include threads on its outer surface, and the cap may include threads on its inner surface. In another embodiment, the cap may be configured to snap onto the tube 66.

[0074] The tube, nozzle, and cap may be made of the same material or different materials. The tube, nozzle, and cap may be made of any material known to those skilled in the art that provides adequate storage for the dental cleaning agent or other product contained within the tube. The materials constituting the components should not react with the components constituting the contents, so as not to render the contents unsafe or otherwise unsuitable for consumer use. Of course, these materials should also be durable enough to withstand normal consumer use without leakage, tearing, or breakage. These materials may be able to protect the oral care composition from environmental variables (e.g., humidity or light) that could damage the composition within its expected shelf life.

[0075] Non-limiting examples of suitable materials for containing dental cleaning products, which may be used to make their components or parts, include polyethylene, such as low-density polyethylene (“LDPE”), linear low-density polyethylene (“LLDPE”), medium-density polyethylene (“MDPE”), and high-density polyethylene (“HDPE”), ethylene acrylate (“EAA”), foil, such as aluminum foil, or any combination of the above materials, for example, formed as a laminate. The thickness of the sidewalls of the tube body may be, for example, from about 0.1 mm to about 0.4 mm, or about 0.3 mm. Thicker or thinner sidewalls may be provided, but it is believed that this would not be particularly cost-effective and would not necessarily provide additional dispensing benefits. The material may be a laminate.

[0076] While the description herein is given primarily in the context of a tube having a single internal chamber, it should be understood that the body of the invention can be divided into multiple chambers, each containing a component portion of the composition. Such embodiments are within the scope of the invention.

[0077] Ion release Using a nozzle as described herein to dispense toothpaste results in improved ion release from the oral care composition in a slurry. For example, when using a nozzle according to an embodiment of the invention, the rate of ion release from the paste particles during brushing can be increased compared to a conventional nozzle comprising an unobstructed circular orifice of the same diameter. Although the oral care composition (such as toothpaste) becomes a slurry during brushing, the ion release profile is improved compared to toothpaste dispensed from an unobstructed circular orifice of the same diameter. When the oral care composition is mixed to form a slurry, the concentration of one or more ions can be used to indirectly measure ion release or dissolution. A greater increase in the concentration of the target analyte indicates a faster release of the surfactant or aesthetic ingredient from the oral care composition.

[0078] When extruded from a nozzle according to an embodiment of the invention, during the initial 2 minutes of external mixing, the rate at which the dental cleaning agent components are released into the slurry may be, for example, at least about 2 times, at least about 5 times, or at least about 8 times the ion release rate measured when the same dental cleaning agent from the same tube is extruded through a conventional round orifice. During the first 60 seconds of mixing, the percentage of theoretical ions released from the dental cleaning agent particles extruded from the nozzle according to an embodiment of the invention may be at least 2 times, at least 3 times, at least 5 times, or at least 6 times the percentage of theoretical ions released when the same dental cleaning agent from the same tube is extruded through a conventional round orifice. During the first 30 seconds of mixing, the AUC of the percentage of theoretical ions released from the dental cleaning agent particles extruded from the nozzle according to an embodiment of the invention may be at least 2 times, at least 3 times, or at least 5 times the AUC of the percentage of theoretical ions released when the same dental cleaning agent from the same tube is extruded through a conventional round orifice.

[0079] Another indirect method for measuring ion release is to measure the slurry pH during mixing of the oral care composition. A faster change in slurry pH indicates a faster release of the active agent or aesthetic component from the oral care composition. The initial percentage change in slurry pH of the dental cleaning paste extruded from a nozzle according to an embodiment of the invention can be greater than the percentage change in slurry pH when the same dental cleaning agent from the same tube is extruded through a conventional round orifice. For example, within the first 120 seconds of mixing, the percentage change in slurry pH of the dental cleaning paste extruded from a nozzle according to an embodiment of the invention can be at least 1.5 times, at least 2 times, at least 2.5 times, or at least 5 times the percentage change in slurry pH of the same dental cleaning agent from the same tube extruded through a conventional round orifice.

[0080] Another indirect method for measuring ingredient release is to measure foam production during brushing. Differences in the rate or amount of foam production indicate that ingredients, such as surfactants, are released from the oral care composition more quickly. The initial rate of foam production when toothpaste particles extruded from a nozzle according to an embodiment of the invention is greater than the initial rate of foam production when the same toothpaste from the same tube is extruded through a conventional round orifice. For example, the amount of foam produced by toothpaste particles extruded from a nozzle according to an embodiment of the invention can be significantly greater than the amount of foam produced when using the same toothpaste from the same tube extruded through a conventional round orifice during the first 10, 20, or 30 seconds of brushing.

[0081] Flavor release Using a nozzle as described herein to dispense toothpaste can result in improved sensory properties. For example, flavor release or presentation can be enhanced when using a nozzle according to an embodiment of the invention compared to a conventional nozzle with an unobstructed circular orifice of the same diameter. Flavor release can be improved either in the paste particles themselves (e.g., pure toothpaste) or in a slurry. For example, flavor release can be improved when toothpaste becomes a slurry during brushing compared to toothpaste dispensed from a conventional circular orifice. Flavor release can be measured by the sum of the peak areas of the total ion chromatogram (TIC) of the flavor components measured in headspace.

[0082] When extruded from a nozzle according to one embodiment of the invention, after about 15 seconds, the increase in the overall flavor release (pure) of the dental cleaning agent may be, for example, at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, or at least 70% higher than the flavor intensity measured when the same dental cleaning agent from the same tube is extruded through a conventional round orifice, or in the range of about 10% to about 90% or about 15% to about 75%. The increase in the overall flavor release (pure) at about 30 seconds may be, for example, at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, or at least 70%, or in the range of about 10% to about 90% or about 15% to about 85%. The increase in the overall flavor release (pure) at about 60 seconds may be, for example, at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, or at least 70%, or in the range of about 10% to about 90% or about 40% to about 50%.

[0083] The increase in total flavor release (slurry) at about 15 seconds may be, for example, at least 10%, at least 20%, or at least 30%, or in the range of about 5% to about 40%, about 10% to about 35%, about 15% to about 30%, or about 18% to about 27%.

[0084] The effect on flavor release can also be measured for individual flavor components. Flavor components may include, but are not limited to, α-pinene, β-pinene, limonene, eucalyptol, menthone, isomenthone, menthyl acetate, menthol, carvone, anethole, myrcene, p-cymene, and combinations thereof. Some individual components may have a greater increase in flavor release compared to other components. For example, the change in flavor release of α-pinene over up to about 60 seconds may be at least 50%, at least 100%, or at least 200%, or in the range of about 50% to about 400%. The change in flavor release of β-pinene over up to about 60 seconds may, for example, be at least 50%, at least 100%, or at least 250%, or in the range of about 50% to about 350%. In another example, the change in flavor release of limonene over up to about 60 seconds may be at least 60%, at least 150%, or at least 300%, or in the range of about 60% to about 425%. For eucalyptol, the flavor release change over a maximum of about 60 seconds may be, for example, at least 30%, at least 75%, or at least 100%, or in the range of about 30% to about 130%. The flavor release change of menthone over a maximum of about 60 seconds may be, for example, at least 25%, at least 50%, or at least 75%, or in the range of about 25% to about 100%. In another example, the flavor release change of isomenthone over a maximum of about 60 seconds may be at least 10%, at least 50%, or at least 70%, or in the range of about 10% to about 85%. For menthyl acetate, the flavor release change over a maximum of about 60 seconds may be, for example, at least 10%, at least 50%, or at least 100%, or in the range of about 10% to about 120%. The flavor release change of menthol over at least about 60 seconds may be, for example, greater than 0%, at least 25%, or at least 60%, or in the range of about -5% to about 75%. In another example, the flavor release change of carvone over a maximum of about 60 seconds may be at least 10%, at least 50%, or at least 70%, or in the range of about 10% to about 80%. For anethole, the flavor release change over a maximum of about 60 seconds may be, for example, at least 20%, at least 50%, or at least 70%, or in the range of about 20% to about 80%. For individual compounds, in a slurry, the flavor release change over a maximum of about 30 seconds may be greater than 0%, at least 30%, or at least 50%, or in the range of about -7% to about 65%.

[0085] Oral care composition Oral care compositions may be in any suitable form, such as solid, liquid, powder, paste, or combinations thereof. Oral care compositions may be dental cleaning agents, teeth whitening gels, subgingival gels, mouthwashes, mousses, foams, oral sprays, lozenges, chewing tablets, chewing gum, teeth whitening strips, dental floss and floss coatings, breath freshening soluble strips, or denture care or adhesive products. Components of dental cleaning agent compositions may be incorporated into film, strip, foam, or fiber-based dental cleaning agent compositions.

[0086] Oral care compositions may include a variety of active and inactive ingredients, such as, but not limited to, hops extract, dicarboxylic acid, calcium ion source, water, fluoride ion source, metal source (such as tin ion source and / or zinc ion source), antibacterial agent, bioactive material, potassium source, quaternary ammonium compound, polyphosphate, humectant, surfactant, buffer, monodentate ligand, polydentate ligand, thickener, abrasive, amino acid (such as neutral or basic amino acid), whitening agent, and any combination thereof. Oral care compositions may contain one or more of the active and inactive ingredients as described in U.S. Patent No. 11,696,881 or U.S. Patent Publication No. 2021 / 0346259, each of which is incorporated herein by reference in its entirety.

[0087] The nozzles or components described herein are particularly suitable for use with oral care compositions with viscosities ranging from 150,000 centipoise to 850,000 centipoise (“cP”). Methods for evaluating viscosity are described in this invention. A Brookfield viscometer is used. ® The viscometer, model DV-I Prime, features a Brookfield “Helipath” stand. Place the viscometer on the Helipath stand and level it via the spirit level. Attach the E-spindle and set the viscometer to 2.5 RPM. Remove the spindle to zero the viscometer and reinstall the E-spindle. Then, before starting the measurement, lower the spindle until the crossbar is partially immersed in the paste. Simultaneously turn on the power switches on both the viscometer and the lifting stand to allow the spindle to begin rotating downwards. Set the timer to 48 seconds and simultaneously turn on the timer, motor, and lifting stand. Obtain the reading after 48 seconds. The reading is in cP.

[0088] Oral care composition form Suitable compositional forms include emulsion compositions such as the emulsion composition of U.S. Patent No. 11,147,753 (the entire contents of which are incorporated herein by reference), unit-dose compositions such as the unit-dose composition of U.S. Patent Application Publication No. 2019 / 0343732 (the entire contents of which are incorporated herein by reference), no-rinse oral care compositions, clogging emulsions such as the clogging oil-in-water emulsion of U.S. Patent No. 11,096,874 (the entire contents of which are incorporated herein by reference), dental cleaning compositions, mouthwash compositions, mouthwash compositions, teeth whitening gels, subgingival gels, mouthwashes, mousses, foams, oral sprays, tablets, chewing tablets, chewing gum, teeth whitening strips, dental floss and floss coatings, breath freshening soluble strips, denture care products, denture adhesive products, or combinations thereof.

[0089] method The oral care compositions described herein can produce beneficial effects on oral health, such as treating, reducing, and / or preventing tooth decay, cavities, gingivitis, and / or combinations thereof, and / or whitening teeth, removing stains from teeth, and / or preventing stain buildup when applied to the oral cavity. For example, a user may dispense at least one inch of a suitable strip or granule of oral care composition as described herein through a nozzle into an oral care appliance such as a toothbrush, applicator, and / or mouth tray, and apply it to the oral cavity and / or teeth. Dispensing the oral care composition using the nozzle described above may include axial extrusion and off-axis extrusion of the oral care composition.

[0090] Users can be instructed to brush their teeth thoroughly for at least 30 seconds, at least one minute, at least 90 seconds, or at least two minutes, at least once, at least twice, or at least three times a day. Users can also be instructed to spit out the oral care composition after brushing. This dispensed composition exhibits faster ion release during brushing compared to a control-dispensed composition prepared by dispensing the oral care composition through a control nozzle comprising a non-clogging circular orifice with an orifice diameter.

[0091] Users may also be instructed to rinse with the mouthwash and / or mouthwash composition after or in place of brushing. Users may be instructed to rinse thoroughly with the oral care composition for at least 30 seconds, at least one minute, at least 90 seconds, or at least two minutes, at least once, at least twice, or at least three times a day. Users may also be instructed to spit out the oral care composition after the process is complete.

[0092] Oral care compositions according to embodiments of the present invention can be used to treat, reduce, and / or prevent dental caries, cavities, gingivitis, and / or combinations thereof. Oral care compositions according to embodiments of the present invention can be used to provide beneficial whitening effects, such as whitening teeth, removing stains from teeth, and / or preventing stain buildup on teeth.

[0093] Oral care compositions may include primary packaging, such as tubes, bottles, and / or drums. The primary packaging may be placed within secondary packaging, such as cartons, shrink wrap, etc. Instructions for use of the oral care composition may be printed on the primary and / or secondary packaging. The scope of this method is intended to include instructions provided by the manufacturer, distributor, and / or producer of the oral care composition.

[0094] If the oral care composition is toothpaste, the user can be instructed to dispense the toothpaste from the tube.

[0095] The user may be instructed to apply a portion of toothpaste to the toothbrush. This portion of toothpaste may be in any suitable shape, such as a strip, a pea-sized amount, or various other shapes that will fit onto any mechanical and / or manual brush head. The user may be instructed to apply a strip of toothpaste at least about 1 inch, at least about 0.5 inches, at least 1 inch, and / or at least 0.5 inches to the bristles of the toothbrush (such as a soft-bristled toothbrush).

[0096] Users can be instructed to apply a pea-sized or rice-grain-sized amount of toothpaste to the bristles of the toothbrush, such as when used by children under 6 years of age and / or under 2 years of age.

[0097] Users can be instructed to brush their teeth for at least approximately 30 seconds, at least approximately 1 minute, at least approximately 90 seconds, at least approximately 2 minutes, at least 30 seconds, at least 1 minute, at least 90 seconds, and / or at least 2 minutes.

[0098] It can instruct users to brush their teeth thoroughly and / or as directed by a doctor and / or dentist.

[0099] Users can be instructed to brush their teeth after each meal. Users can be instructed to brush their teeth at least once, at least twice, and / or at least three times a day. Users can be instructed to brush their teeth no more than three times a day, for example, to prevent Sn staining. Users can be instructed to brush their teeth in the morning and / or before going to bed at night.

[0100] Because the toothpaste composition contains ingredients that are not suitable for ingestion, such as fluoride, the user may be instructed not to swallow it. However, in the case of oral care compositions that contain hops but not fluoride, it may not be necessary to instruct the user not to swallow the toothpaste. The user may be instructed to spit out (or cough up) the toothpaste composition after stopping the brushing cycle.

[0101] It can instruct users to dispense mouthwash from a bottle containing mouthwash.

[0102] Users may be instructed to use mouthwash at least once a day, at least twice a day, and / or at least three times a day.

[0103] Users can be instructed to use the mouthwash composition after using toothpaste and / or dental floss.

[0104] The user can be instructed to rinse their mouth with a portion of mouthwash for a period of time, such as between their teeth. The user can also be instructed to rinse vigorously with a portion of mouthwash.

[0105] Users can be instructed to use approximately 5 mL to approximately 50 mL, approximately 10 mL to approximately 40 mL, 10 mL, 20 mL, 25 mL, 30 mL, 40 mL, 2 teaspoons, and / or 4 teaspoons of mouthwash.

[0106] Users may be instructed to rinse their mouths with mouthwash for at least approximately 30 seconds, at least approximately 1 minute, at least approximately 90 seconds, at least approximately 2 minutes, at least 30 seconds, at least 1 minute, at least 90 seconds, and / or at least 2 minutes.

[0107] Because the mouthwash composition contains ingredients that are not suitable for ingestion, such as fluoride, the user may be instructed not to swallow it. However, in the case of oral care compositions that contain hops but not fluoride, it may not be necessary to instruct the user not to swallow the mouthwash. The user may be instructed to spit out (or cough up) the mouthwash composition after stopping the rinsing cycle.

[0108] Instructions for use of oral care compositions such as toothpaste compositions and / or mouthwashes may vary based on age. For example, one set of instructions may be provided for adults and children aged at least 6 years or at least 2 years, while a second set of instructions may be provided for children aged 6 years or less.

[0109] Additionally, as described herein, oral care compositions can be used to reduce the number and / or intensity of white patches on teeth that may be attributable to the presence of dental caries in the oral cavity. Alternatively, oral care compositions as described herein can be used to reduce redness, swelling, tenderness, and / or edema of the gingiva at the gingival line immediately adjacent to the tooth surface (which may be attributable to the presence of gingivitis in the oral cavity).

[0110] combination A. A method for using an oral care composition, the method comprising: The oral care composition is dispensed through a nozzle to form a dispensed composition, wherein the nozzle comprises: An orifice having a central axis and an orifice diameter; and Fins, wherein the fins partially block the orifice; and Brush your teeth with the dispensed composition to form a paste. The oral care composition dispensed by means of a control dispensing prepared by dispensing the oral care composition through a control nozzle comprising an unobstructed circular orifice having the orifice diameter has a faster ion release during brushing.

[0111] B. According to the method disclosed in A, the center of the orifice is blocked.

[0112] C. The method according to claim A or claim B, wherein the nozzle further includes a central hub, wherein the fins are coupled to the central hub.

[0113] D. According to the method disclosed in A, wherein the fins do not contact the central hub.

[0114] E. The method disclosed in any one of A to D, wherein each of the fins has an upper surface and a lower surface, and the upper surface of each of the fins is located distal to the orifice.

[0115] F. The method disclosed in any one of A to E, wherein the lower surface of each fin is located near the orifice.

[0116] G. The method disclosed in any one of A to F, wherein the lower surface of each fin is located distal to the orifice.

[0117] H. The method disclosed in any one of A to G, wherein the nozzle further includes an axial extrusion region and an off-axis extrusion region.

[0118] I. The method disclosed in any one of A to H, wherein the nozzle further includes a sidewall defining the orifice, wherein the sidewall includes an inner wall, an edge, and an outer wall.

[0119] J. According to the method disclosed in I, each of the fins further includes an outer end of the outer wall extending into the sidewall.

[0120] K. According to the method disclosed in I, the lower surface of each fin in the fin extends from the inner surface of the sidewall.

[0121] L. The method disclosed in any one of A to K, wherein the oral care composition comprises fluoride, and after brushing for 15 seconds, the fluoride concentration in the paste is greater than the control fluoride concentration in the control paste after brushing for 15 seconds with the control-split composition.

[0122] M. According to the method disclosed in L, the concentration of said fluoride is more than three times the concentration of said control fluoride.

[0123] N. The method disclosed in any one of A to L, wherein the oral care composition comprises fluoride, and after brushing for 30 seconds, the fluoride concentration in the paste is greater than the control fluoride concentration in the control paste after brushing for 30 seconds with the control-split composition.

[0124] O. According to the method disclosed in N, the concentration of said fluoride is more than twice the concentration of said control fluoride.

[0125] P. A method for using an oral care composition, the method comprising: The oral care composition is dispensed through a nozzle to form a dispensed composition, wherein the nozzle comprises: An orifice having a central axis and an orifice diameter; and Fins, wherein the fins partially block the orifice; Add the dispensed composition to the liquid; and To form a slurry of the dispensed composition and the liquid. The dispensed composition exhibits faster ion release in the slurry compared to a control-dispensed composition prepared by dispensing the oral care composition through a control nozzle comprising an unobstructed circular orifice having the orifice diameter.

[0126] Q. Use of nozzles with partially blocked orifices for increasing the initial ion release rate of oral care compositions. Example

[0127] The following embodiments further illustrate the invention, and these embodiments should not be construed in any way as limiting the scope of the invention. After reading this specification, various other aspects, modifications, and equivalents thereof may be proposed to those skilled in the art without departing from the spirit of the invention or the scope of the appended claims.

[0128] Methods for measuring ion release Sample preparation A sample for evaluating changes in ion release or dissolution of a given dental cleaning agent is prepared by squeezing a sample from the same tube of dental cleaning agent through a given nozzle into an 80 mL titration cup. This is similar to using Mettler Toledo. ® The sample weight was measured using an XPE 504 balance (Mettler Toledo, Columbus, OH, USA), with a sample weight of 2.0 g (+ / - 0.5 g).

[0129] Titrator Analysis Methods Place the cup with the Mettler Toledo ® The T7 titrator (Mettler-Toledo Corporation, Columbus, Ohio, USA) is equipped with a Mettler Toledo... ® On the SD 660 autosampler (Mettler-Toledo, Columbus, Ohio, USA), the Mettler Toledo... ®A propeller-driven stirrer (Mettler-Toledo, Columbus, Ohio, USA) and a fluoride ion selective electrode (ISE) (Thermo Scientific, Chelmsford, MA, USA; part number 9609BNEP) or a pH probe (Cole-Parmer pH Probe, Vernon Hills, IL, USA; part number 05990-65) were inserted. A titrator was used to mechanically add 20 mL of solution from Millipore to the beaker. ® Milli-QIQ 7000 system (MilliporeSigma, Rockville, MD, USA; Part No. ZIQ7000T0C) Milli-Q ® Water and 20 mL of 1% TISAB II buffer (Thermo Fisher Scientific, Rockwood, TN, USA; Part No. 940909). The impeller was agitated at 31% (pH) or 32% (fluoride) using Lab-X software (Mettler Toledo, Columbus, Ohio). For fluoride measurements, the ISE measured the amount of fluoride ions released into the water:TISAB II mixture as the impeller agitated the paste into the solution over several minutes. For pH measurements, the pH probe measured the millivolt change in the solution after 6 minutes of impeller agitation dispersing the paste into the slurry solution. This process was repeated 6 times for each nozzle.

[0130] Data processing Based on the recorded sample weight and the prepared concentration of 1100 μg / g fluoride ions in the final product paste, the absolute fluoride ion concentration (F) in the solution was determined. - The concentration is converted into a percentage of the total theoretical fluoride ion content. This method normalizes the data, thus allowing direct comparisons between samples.

[0131] Direct comparison of slurry pH data; no mathematical normalization.

[0132] Analyte release is used to represent the release of a component from the composition. The methods described above and the results below are based on measurements of fluoride ion release or changes in slurry pH. It is worth noting that other analytes or ions present in the formulation can be selected to demonstrate the rate of release of individual components from the paste. For example, the target analyte could be potassium or sodium. Alternatively, a non-specific measurement of total conductivity can be used as an endpoint. Any of the measurement techniques described above is suitable for measuring the release rate of dental cleaning agents in water.

[0133] nozzle The effect of nozzle design on ion release or dissolution was evaluated using comparative nozzle 1 and nozzles 1 to 3 of the present invention. Comparative nozzle 1 has a circular, unobstructed orifice with a diameter of approximately 9.0 mm. Nozzles 1 to 3 of the present invention are described in Table 1. The fins of nozzles 1 to 3 of the present invention are not tilted (i.e., at a 0° angle).

[0134] Table 1: Nozzle Design Fluoride release results and discussion Crest ® Professional Healthy Fresh Mint (Crest) ® Fluoride concentrations were measured over time as Pro-Health Clean Mint (“Pro-Health”) was mixed to form a slurry. Fluoride slurry concentration data for each sample are shown in Table 2 below.

[0135] Table 2: Theoretical F over time - Percentage of ions released Unexpectedly, the results in Table 2 (which are also shown in...) Figure 10The results show that, compared to the control nozzle 1, the nozzle 1 of the present invention has a higher fluoride concentration in the slurry at all stirring times. Given sufficient mixing time, it is expected that the percentage of ions released from the same dental cleaning agent but different nozzles will reach the same endpoint. Because the data were normalized as discussed above, and because the same dental cleaning agent was used, it is believed that this faster release of fluoride is due to the partially blocked design of the nozzle 1 of the present invention. The faster release of fluoride indicates that the dental cleaning agent extruded through the nozzle 1 of the present invention has a faster initial dissolution rate than the dental cleaning agent extruded through the control nozzle 1. The dental cleaning agent is blue in color, and the significant difference in release rate can also be visually observed. The slurry from the nozzle 1 of the present invention turns opaque blue almost immediately after stirring begins, while the dental cleaning agent particles from the control nozzle 1 remain intact in a clear solution during the initial stirring time. The effect of the partially blocked nozzle orifice on the ion release rate is unknown. As previously mentioned, many users brush their teeth for less time than recommended. The faster ion release from dental floss and thus the resulting faster release of surfactants increases the amount of time during which surfactants can provide their corresponding benefits before the dental floss is spat out during any given brushing process. Given that the action of dental floss is localized and the oral cavity is primarily a cleaning organ (meaning that saliva flow and swallowing constantly rinse the oral tissues), the kinetics of ingredient release are very important.

[0136] As a comparison, the area under the curve (AUC) of both the comparative nozzle 1 and the nozzle 1 of the present invention was calculated. Quantifying the data in this way helps to distinguish the relative ion release performance of each type of dispensing (through either nozzle). AUC is a mathematical expression of the amount of active substance available in the oral cavity at a given slurry time. The results are shown in Table 3 and Figure 11 middle.

[0137] Table 3: Theoretical F over time - AUC of ion release percentage Figure 11 The first 30 seconds of the mixture are shown. Figure 11 The results show that, with all other variables held constant, the toothpaste extruded through nozzle 1 of the present invention releases significantly more fluoride in the first few seconds of stirring compared to the same toothpaste extruded through comparative nozzle 1. These results indicate that, compared to conventional non-clogging nozzles, users will experience the benefits of toothpaste more quickly when using the nozzle according to an embodiment of the present invention.

[0138] To further evaluate the effect of nozzle design over time, the paste extruded by comparing nozzle 1 and nozzle 1 of the present invention was stirred until 100% of the theoretical fluoride ions were released. The results are shown in Table 4 and Figure 12 The numerical differences in ion release (%) between nozzle 1 and nozzle 1 of the present invention are also shown in Table 4 and... Figure 13 middle.

[0139] Table 4: Percentage of maximum fluoride ion release into the slurry The nozzle 1 of this invention results in rapid ion release from the paste during the first few seconds of in vitro stirring. This release rate peaks after approximately 2 minutes of slow in vitro stirring, then stabilizes until 100% ion release is achieved. In contrast, nozzle 1 produces a stable ion release rate throughout the entire stirring time.

[0140] The nozzle 1 of the present invention causes a rapid release of ions during initial stirring, while the contrast nozzle 1 causes a relatively stable release of ions over time. Figure 14 The rate of change of the theoretical ion release percentage during the first two minutes of slurry preparation is shown. Two minutes after mixing begins, the ion release rate of nozzle 1 of the present invention is approximately 0.62 ppm / s, while the ion release rate of the control nozzle 1 is approximately 0.08 ppm / s. Although both designs produce paste particles that ultimately achieve 100% ion release, nozzle 1 of the present invention increases the ion release rate by approximately eight times during the first two minutes.

[0141] Given these surprising results, the effect of the additional partially blocked nozzle design (nozzles 2 and 3 of the present invention) on ion release was evaluated. Table 5 shows the AUC results of the fluoride concentration over time measured at 30 seconds of mixing, comparing the control nozzle 1 and nozzles 1 to 3 of the present invention. The results are also shown in... Figure 15 middle.

[0142] Table 5: Theoretical F over 30 seconds - AUC of ion release percentage These results demonstrate a previously unknown positive correlation between orifice clogging and enhanced ion release from dental cleaning paste particles.

[0143] Shear control comparison To better understand the mechanism behind the surprising correlation between orifice clogging and ion release, additional research on the effect of shear force on ion release in dental cleaning agents was evaluated. In addition to control nozzle 1, three prototype nozzles were developed to investigate the effect of shear on ion release. Compared with control nozzle 2 ( Figures 17A to 17E Compared to 11.0mm, nozzle 1 ( Figures 16A to 16E It has an inner wall length of 7.0 mm. (For example...) Figures 18A to 18E As shown, the nozzle 4 of the present invention has a set of fins and a corresponding central hub inside the nozzle. For example... Figures 19A to 19E As shown, the nozzle 5 of the present invention has two sets of fins and a corresponding central hub inside the nozzle. Table 6 and Figure 20The results show the area under the curve (AUC) of fluoride ion release after 30 seconds of mixing, comparing nozzles 1 and 2 with nozzles 4 and 5 of the present invention.

[0144] Table 6: Theoretical F for various nozzles - Percentage of ions released These results suggest that mechanical shearing may not have a strictly linear relationship with enhanced ion release from toothpaste particles, but there may be a shear threshold that can produce a significantly increased release rate. Because the partially blocked orifice of the nozzle of this invention imparts changes to both shear force and surface area, it is likely that both factors can play a role in enhanced ion release. For example, when comparing the results of nozzles 1 and 2, a positive correlation was found between simply elongating the nozzle and an increase in the ion dissolution rate. This is likely due to the shear wall effect and laminar flow of the paste composition along the nozzle wall during dispensing. Additionally, any design parameters that cause changes in orifice blockage size or paste flow path can also alter the shear rate of the system, which can also affect the dissolution rate. It is noteworthy that toothpaste is both a yield stress fluid and a shear-thinning fluid, initiating flow only when shear stress / force is applied and thinning as shear force and / or shear rate increase. Furthermore, any viscosity reduction that may occur due to the applied force can additionally play a role in enhancing ion release during slurry formation.

[0145] Comparison of dental cleaning agent bases The effects of various dental floss bases with different initial hydration levels on ion release from partially clogged pores were evaluated. Three different dental floss formulations with different water contents and binder systems were tested. Three dental flosses were used: Crest ProHealth (floss A), Crest CavityProtection (floss B), and Crest ProHealth Advanced (floss C). Floss A had a high water content of 35.8%, floss B had a medium water content of 30.9%, and floss C was anhydrous, containing less than 1.0% water. Table 7 shows the results comparing the three dental flosses. Figure 21 A comparison of the theoretical fluoride ion release percentages from dental cleaning agents A to C is shown for comparative nozzle 1 and nozzle 1 of the present invention. Figure 22 The theoretical percentage of fluoride ions released from dental cleaning agents A to C after 30 seconds is shown for nozzle 1 of the present invention.

[0146] Table 7: Theoretical F-ion release percentage for various dental cleaning agents Interestingly, the results showed that for both high and medium moisture content substrates, the shaped orifice provided a significant enhancement in ion release rates. Dispensing the dental floss agent C (anhydrous product) through the shaped orifice (applying shear force and increasing surface area) appeared to have no effect on the rate of ion release into the slurry. When slurried under these moderate mixing conditions, the anhydrous dental floss agent continued to exhibit a slow linear ion release rate for both nozzle types.

[0147] pH Results and Discussion When Crest ® The pH was assessed over time as the Pro-Health peppermint was blended to form a slurry. The pH was determined based on the mV readings of the slurry. The mV data for each sample (n=6) are shown in Table 8 below.

[0148] Table 8: Raw Data of Average mV Readings Because pH probe readings require a few seconds to stabilize in each new solution, the probe is allowed to equilibrate before setting t=0. The baseline measurement is the probe's mV reading when initially placed in the sample solution. Once the probe is equilibrated and the reading has stabilized, the timer starts at t=0.

[0149] The percentage change in mV readings over time relative to baseline readings is shown in Table 9. The average pH over time, calculated from the mV data, is shown in Table 10.

[0150] Table 9: Percentage change in mV relative to baseline Table 10: Average pH over time Unexpectedly, the results in Tables 8 to 10 (which are also shown in...) Figures 23 to 25 The results show that, compared to control nozzle 1, the pH in the slurry produced by nozzle 1 of the present invention exhibits a greater increase relative to the baseline across all stirring times. Given sufficient mixing time, it is expected that the same dental floss but different nozzles will have the same effect on pH to reach the same endpoint. Because the same dental floss is used, this faster pH change is believed to be due to the partially blocked design of nozzle 1 of the present invention. The faster pH change indicates that the dental floss extruded through nozzle 1 of the present invention has a faster initial dissolution rate than that extruded through control nozzle 1. The effect of the partially blocked nozzle orifice on the rate of pH change is unknown. As previously mentioned, many users brush their teeth for less time than recommended. As discussed above, faster release of the surfactant increases the amount of time during which the surfactant can provide its corresponding benefits before the dental floss is spat out during any given brushing session.

[0151] Methods for measuring foam generation Compare the effects of nozzle 1 and nozzle 1 of the present invention on foam generation.

[0152] Sample preparation The sample used to evaluate the effect of nozzle shape on foam production was prepared by squeezing 1.0 g (+ / - 0.1 g) of dental cleaning agent sample from the same tube of dental cleaning agent through a given nozzle onto a toothbrush (Anchor, 41 bundle white toothbrush, Team Technologies, Inc, Morristown, TN, USA; Part No. 07771HC).

[0153] Foam Analysis Methods The Descriptive Profiling Team (“DPP”) conducted sensory tests to understand the amount of foam produced by three dental floss formulations that differed in the amount of foam dispensed by each nozzle shape. The three formulations included Crest. ® Professional Healthy Gum Cleaning (Crest) ® Pro-Health Gum Detoxify, Crest ® Professional Health Premium Series Deep Cleansing Mint (Crest) ® Pro-Health Advanced Deep Clean Mint and Crest ® 3D dazzling white mint (Crest) ® 3D White Brilliance Vibrant Peppermint). The DPP team consisted of 12 to 14 team members who were working on the modified Spectrum. ™ The descriptive analysis method was trained and validated. Team members assessed foam volume at six time points, spaced 10 seconds apart, while brushing their teeth. Following a standardized 60-second brushing protocol, each time point was evaluated on a scale ranging from 0 (no foam) to 60 (extreme foam volume). JMP was used for the evaluation. ® Results were analyzed using Pro 17.1.0 (JMP Statistical Discovery LLC, Cary, NC). Descriptive group results data for all group members were averaged, and order was defined as a random variable. The complete model included ointment and nozzle as primary effects. Least squares means were calculated using Fisher's method of least significance (p<0.05).

[0154] Bubble Results and Discussion The foam production of three different toothpastes dispensed from two different nozzles was evaluated over time. The results of the expert panel analysis of foam production for each nozzle are shown in Table 11 below.

[0155] Table 11: Effect of nozzles on foam over time The results in Table 11 show that the nozzle 1 of the present invention produces more foam than the control nozzle 1 over time. At each evaluation time point, the nozzle 1 of the present invention consistently tends to produce more foam than the control nozzle 1. Given sufficient time, it is expected that the same dental cleaning agent but different nozzles will produce the same amount of foam to the same endpoint. Notably, a statistically significant difference was observed at the 20-second time point. p <0.05), wherein the nozzle 1 of the present invention produces significantly more foam than the comparative nozzle 1. This indicates that the nozzle 1 of the present invention has a more significant effect on foam production during the early stages of brushing when foam begins to form. The effect of a partially blocked nozzle orifice on the foam production rate is unknown.

[0156] The dimensions and values ​​disclosed herein should not be construed as strictly limited to the precise numerical values ​​cited. Rather, unless otherwise specified, each such dimension is intended to represent the stated value and the range surrounding its functional equivalent. For example, a dimension disclosed as “40 mm” is intended to represent “approximately 40 mm”.

[0157] Unless expressly excluded or otherwise limited, every reference cited herein, including any cross-references or related patents or patent applications, and any patent application or patent claiming priority to or benefiting from it, is incorporated herein by reference in its entirety. A reference to any document is not an admission that it is prior art concerning any invention disclosed or claimed herein, nor is it an admission that it, alone or in any combination with any other reference, teaches, suggests, or discloses any such invention. Furthermore, where any meaning or definition of a term in this invention conflicts with any meaning or definition of the same term in a referenced document, the meaning or definition given to that term in this invention shall prevail.

[0158] While specific embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Therefore, it is intended that all such changes and modifications falling within the scope of the invention be covered by the appended claims.

Claims

1. A method for using an oral care composition, the method comprising: The oral care composition is dispensed through a nozzle to form a dispensed composition, wherein the nozzle comprises: An orifice, the orifice having a central axis and an orifice diameter; and Fins, the fins partially blocking the orifice; and Brush your teeth with the dispensed composition to form a paste. The dispensed composition has a faster ion release during brushing compared to a control dispensed composition, the control dispensed composition being formed by dispensing the oral care composition through a control nozzle comprising a non-clogging circular orifice having the orifice diameter.

2. The method according to claim 1, wherein the orifice is centrally blocked, preferably wherein the nozzle further includes a central hub, wherein the fins are connected to the central hub.

3. The method according to claim 1, wherein the fins do not contact the central hub.

4. The method according to any one of claims 1-3, wherein each of the fins has an upper surface and a lower surface, and the upper surface of each of the fins is located distal to the orifice.

5. The method according to any one of claims 1-4, wherein the lower surface of each of the fins is located near the orifice.

6. The method according to any one of claims 1-5, wherein the lower surface of each of the fins is located distal to the orifice.

7. The method according to any one of claims 1-6, wherein the nozzle further comprises an axial extrusion region and an off-axis extrusion region.

8. The method according to any one of claims 1-7, wherein the nozzle further comprises a sidewall defining the orifice, wherein the sidewall comprises an inner wall, an edge, and an outer wall.

9. The method of claim 8, wherein each of the fins further comprises an outer end extending to the outer wall of the sidewall.

10. The method of claim 8, wherein the lower surface of each fin extends from the inner surface of the sidewall.

11. The method according to any one of claims 1-10, wherein the oral care composition comprises fluoride, and after brushing for 15 seconds, the fluoride concentration in the paste is greater than the control fluoride concentration in the control paste after brushing the control-split composition for 15 seconds.

12. The method of claim 11, wherein the fluoride concentration is more than three times the control fluoride concentration.

13. The method according to any one of claims 1-12, wherein the oral care composition comprises fluoride, and after brushing for 30 seconds, the fluoride concentration in the paste is greater than the control fluoride concentration in the control paste after brushing the control-split composition for 30 seconds.

14. The method of claim 13, wherein the fluoride concentration is more than twice the control fluoride concentration.

15. A method for using an oral care composition, the method comprising: The oral care composition is dispensed through a nozzle to form a dispensed composition, wherein the nozzle comprises: An orifice, the orifice having a central axis and an orifice diameter; and Fins that partially block the orifice; Add the dispensed composition to the liquid; and To form a slurry of the dispensed composition and the liquid. The dispensed composition exhibits faster ion release in the slurry compared to a control dispensed composition, the control dispensed composition being formed by dispensing the oral care composition through a control nozzle comprising a non-clogging circular orifice having the orifice diameter.

16. Use of a nozzle having a partially blocked orifice for increasing the initial ion release rate of a dispensed oral care composition.

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