Individualized aberration compensation and depth-of-field fusion type implantable contact lens based on calculation of optical wavefront regulation and preparation method thereof

Abstract

The invention relates to a personalized aberration compensation and depth-of-field fusion type implantable contact lens based on calculation optical wavefront regulation and control, and belongs to the crossing field of ophthalmic medical instruments and calculation optics. A composite wavefront regulation and control structure is formed on at least one optical surface of an optical area of a lens main body of the contact lens; a target phase function corresponding to the composite wavefront regulation and control structure is a two-dimensional function and at least comprises an aberration compensation phase term used for compensating wavefront aberration of a target eyeball and a depth-of-field extension phase term used for generating an extension focal depth; the target phase function is determined through a computational optical reverse optimization method, the optimization process aims at improving the imaging quality of the eyeball-ICL combined optical system under a plurality of preset object distances, and meanwhile, the expected positioning error of the ICL relative to the pupil is used as a robustness constraint condition. The problems of individualized aberration correction and continuous depth-of-field expansion are solved, and a novel ICL solution with high visual quality, high clinical robustness and manufacturability is provided.

Description

Technical Field

[0001] This invention belongs to the interdisciplinary field of ophthalmic medical devices and computational optics, and relates to a personalized aberration compensation and depth-of-field fusion implantable contact lens based on computational optics wavefront modulation and its preparation method. Background Technology

[0002] Implantable contact lenses (ICLs) are one of the mainstream solutions for correcting high myopia and astigmatism, and their optical performance continues to evolve. Traditional ICL designs mainly focus on correcting low-order aberrations such as spherical and cylindrical lenses. With patients' increasing demands for postoperative visual quality, especially night vision and intermediate vision, ICLs that provide extended depth of focus (EDoF) have become a research hotspot. Current technological approaches to achieving EDoF mainly include: using aspherical designs to introduce specific spherical aberrations to extend the depth of focus; and using diffractive optical elements (such as annular diffraction gratings) to generate multiple discrete focal points.

[0003] However, these existing technologies have inherent limitations: First, whether it's a refractive aspherical or diffractive multifocal design, their optical functions are relatively fixed and cannot compensate for the unique higher-order aberrations of an individual's eye (such as coma and cloverleaf aberration), which are significant factors causing visual disturbances such as nighttime glare and halos. Second, traditional EDoF designs are usually based on rotational symmetry models, failing to deeply integrate and optimize with the asymmetry required for astigmatism correction and the asymmetry of potential higher-order aberrations, potentially leading to poor visual quality on the astigmatic axis. Furthermore, the final position of the ICL within the eye (oculus height, eccentricity, tilt, rotation) has clinical uncertainty; existing fixed designs are sensitive to such positioning errors, potentially causing a significant decrease in theoretical optical performance after actual implantation.

[0004] Computational optics offers a new solution to these problems. It works by setting a desired imaging effect (such as forming a continuous, sharp focal length on the retina) and then inversely solving for the optimal wavefront phase modulation required by the optical element. Currently, this technology is mostly used in external optical systems such as microscopes and telescopes. However, in the field of implantable optics (ICLs), which require implantation and face complex bio-optical environments and strict manufacturing constraints, how to construct a computational optics ICL that combines personalized aberration compensation, large depth of field, strong clinical robustness, and mass production capability remains a critical technical challenge that needs to be overcome. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a personalized aberration compensation and depth-of-field fusion implantable contact lens based on computational optical wavefront modulation and its manufacturing method. The lens achieves precise compensation for low-order and high-order aberrations of the individual eye by constructing a globally inversely optimized composite phase structure on its optical surface, and simultaneously expands the visual depth of field, thereby improving the overall visual quality after implantation.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] A personalized aberration compensation and depth-of-field fusion implantable contact lens based on computational optical wavefront modulation includes a lens body with optical refractive power, and a composite wavefront modulation structure is formed on at least one optical surface of the optical region of the lens body; the target phase function corresponding to the composite wavefront modulation structure is... It is a two-dimensional function that at least includes an aberration compensation phase term for compensating for wavefront aberrations of the target eye. and depth-of-field extension phase term used to generate extended depth of focus Wherein, the target phase function The optimization process, determined by computational optical inverse optimization, aims to improve the imaging quality of the eye-ICL combined optical system at multiple preset object distances, while simultaneously using the expected positioning error of the ICL relative to the pupil as a robust constraint.

[0008] Furthermore, the composite wavefront modulation structure is integrally composed of a base surface shape that provides the basic refractive power and a phase modulation microstructure superimposed thereon; the physical height distribution of the phase modulation microstructure... With the target phase function The following relationship must be satisfied: ,in, To design the center wavelength, , The refractive index of the material of the lens body is given. The refractive index of the aqueous humor in the eye.

[0009] Furthermore, in the computational optical inverse optimization method, the expected positioning error includes at least one of eccentricity, tilt angle, and rotation angle, and is incorporated into the objective function or constraints during the optimization process through Monte Carlo simulation or multi-configuration optimization.

[0010] Furthermore, the composite wavefront modulation structure includes a continuous surface shape, a multi-level stepped surface shape, or a discrete phase modulation unit array; the phase modulation unit array is arranged in one of the following ways: concentric rings, non-concentric rings, or aperiodic arrangement.

[0011] Furthermore, the depth-of-field extension phase term A radially varying energy distribution strategy is employed, which causes the modulation intensity of the phase modulation microstructure to gradually increase or decrease from the optical center to the edge, thereby achieving halo suppression.

[0012] Furthermore, the computational optics inverse optimization method also introduces manufacturing process constraints, which include at least one of the following: minimum lateral feature size of the phase modulation microstructure, maximum surface slope angle, or number of surface quantization steps.

[0013] Furthermore, the optical area surface of the lens body or the support haptic is provided with positioning marks for intraoperative axial alignment; the aberration compensation phase term It is a non-rotationally symmetric two-dimensional phase distribution, and its main compensation direction is associated with the axis indicated by the positioning mark.

[0014] The present invention also provides a method for manufacturing the contact lens, the method comprising the following steps: S1: Acquire wavefront aberration data and corneal topography data of the target eye; S2: Based on the wavefront aberration data, generate an initial aberration compensation phase term. ; S3: Construct a joint optimization model that includes an eyeball optical model, a contact lens substrate model, and a statistical model of expected positioning error; S4: In the joint optimization model, the main objective is to maximize the weighted average value of the modulation transfer function (MTF) under a preset object distance set, with the expected positioning error as a robust constraint, and the depth-of-field extension phase term is obtained through iterative algorithm optimization. This allows for the fusion of the phase functions to obtain the final target phase function. ; S5: According to the target phase function Based on the high mapping relationship described in claim 2, the machinable surface shape data of the composite wavefront modulation structure is generated; S6: Based on the machinable surface data, the composite wavefront modulation structure is formed on a designated optical surface of the ICL substrate.

[0015] Furthermore, the optimization process in step S4 is carried out simultaneously under at least two characteristic pupil diameters (photopic pupil and scotopic pupil), and the color difference at at least two wavelengths (such as 486nm, 550nm, and 656nm) is evaluated and constrained.

[0016] Furthermore, the processing technology in step S6 is one or more combinations of grayscale mask lithography, femtosecond laser two-photon polymerization direct writing, nanoimprint transfer, or single-point diamond turning.

[0017] The beneficial effects of this invention are as follows: Compared with the prior art, the ICL solution provided by the present invention has the following significant advantages: True wavefront personalization: It not only corrects myopia and astigmatism, but also compensates for higher-order aberrations based on individual data, improving visual quality from the optical root, especially improving vision in complex lighting environments such as night driving.

[0018] Smooth and continuous visual experience: By calculating the optically optimized EDoF phase, it provides continuous depth of focus from near to far, avoiding the image jumpiness and intermediate visual dips in traditional multifocal designs.

[0019] Excellent clinical robustness: The tolerance for implantation positioning errors was considered and optimized during the design phase, making the product more stable in actual use and reducing the risk of visual quality decline due to minor postoperative misalignment.

[0020] Design and manufacturing closed loop: By placing manufacturing process constraints at the forefront of the optical design stage, the feasibility of the pathway from "ideal phase" to "machinable surface shape" and then to "solid lens" is ensured, thereby improving the efficiency of results transformation.

[0021] Overall visual comfort improvement: Through built-in halo suppression optimization, the side effects that may be caused by complex phase structure are effectively controlled, thereby improving the visual comfort and satisfaction of patients.

[0022] Other advantages, objectives, and features of the invention will be set forth in part in the description which follows, and in part will be apparent to those skilled in the art from the following examination, or may be learned from practice of the invention. The objectives and other advantages of the invention can be realized and obtained through the following description. Attached Figure Description

[0023] To make the objectives, technical solutions, and advantages of the present invention clearer, the preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings, wherein: Figure 1 This is a schematic diagram of the physical carrier according to an embodiment of the present invention; Figure 2 Flowchart for computational optics inverse optimization design; Figure 3 For the target phase function Two-dimensional distribution map; Figure 4 Surface morphology of composite wavefront modulated structures Schematic diagram; Figure 5 MTF vs. rotational error comparison curves (robustness verification graph); Figure 6 Comparison of PSF radial energy distribution (halo suppression verification image); Figure 7 This is a schematic diagram of the grayscale photolithography process. Detailed Implementation

[0024] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the illustrations provided in the following embodiments are only schematic representations of the basic concept of the present invention. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0025] The accompanying drawings are for illustrative purposes only and are schematic diagrams, not actual pictures. They should not be construed as limiting the invention. To better illustrate the embodiments of the invention, some parts in the drawings may be omitted, enlarged, or reduced, and do not represent the actual product dimensions. It is understandable to those skilled in the art that some well-known structures and their descriptions may be omitted in the drawings.

[0026] In the accompanying drawings of the embodiments of the present invention, the same or similar reference numerals correspond to the same or similar components. In the description of the present invention, it should be understood that if terms such as "upper," "lower," "left," "right," "front," and "rear" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, they are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the terms used to describe positional relationships in the drawings are only for illustrative purposes and should not be construed as limiting the present invention. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0027] The purpose of this invention is to overcome the shortcomings of existing implantable collamer lens (ICL) technology in terms of personalized aberration correction, depth of field extension, and clinical tolerance, and to provide a novel implantable contact lens based on computational optical wavefront modulation and its design and manufacturing method. This approach aims to simultaneously achieve the following through a globally inversely optimized "composite wavefront modulation structure": precise compensation for low-order and key high-order aberrations of the individual eye; continuous and high-quality extended depth of field within a target range (e.g., 0.3m to infinity); good robustness to common positioning errors (eccentricity, tilt, rotation) during implantation; and suppression of stray light and halos that may be introduced by the phase structure through design optimization.

[0028] Figure 1This is a schematic diagram of the physical carrier of an embodiment of the present invention, used to illustrate the overall structure of an implantable contact lens. The composite wavefront modulation structure is the core technical feature of the present invention; it is not a traditional concentric circle diffraction structure, but rather a complex micro-nano scale texture that carries personalized aberration compensation and depth-of-field extension functions. For example... Figure 1 As shown, the contact lens includes a lens body with optical refractive power, and a composite wavefront modulation structure is formed on at least one optical surface of the optical region of the lens body; the target phase function corresponding to the composite wavefront modulation structure is... It is a two-dimensional function that at least includes an aberration compensation phase term for compensating for wavefront aberrations of the target eye. and depth-of-field extension phase term used to generate extended depth of focus Wherein, the target phase function The optimization process, determined by computational optical inverse optimization, aims to improve the imaging quality of the eye-ICL combined optical system at multiple preset object distances, while simultaneously using the expected positioning error of the ICL relative to the pupil as a robust constraint.

[0029] The core solution of this invention includes: 1. Description of composite wavefront modulation structure and its phase function: A "composite wavefront modulation structure" is designed and fabricated on an optical surface (such as the front or back surface) within the ICL optical region. This structure is not a simple superposition of traditional geometric structures, but rather consists of a unified, two-dimensional target phase function. Defined. It can be broken down into two core parts: Aberration Compensation Phase Term Generated based on preoperative individual ocular wavefront aberration data (such as Zernike coefficients), used to counteract inherent ocular defocus, astigmatism, and selected higher-order aberration components.

[0030] Depth of field extension phase term It is optimized through computational optical inverse design algorithm. Its goal is to make the eye-ICL joint system form a longitudinally extended depth of focus with the most uniform light intensity distribution at the retina under a series of preset object distances, rather than a discrete focus.

[0031] Figure 3 For the target phase function The two-dimensional distribution diagram, which serves as the core blueprint for optical control, uses color intensity to represent the phase delay (range 0 to 2π) of light passing through corresponding positions. Its core technical feature is a non-rotationally symmetric structure. This design is intended to adapt to the personalized aberration correction needs of patients, such as astigmatism and coma, overcoming the limitation of traditional rotationally symmetric phase structures in compensating for asymmetric aberrations; the phase function is compensated for by aberrations. With depth-of-field extension phase The directional differences in composition and color distribution directly correspond to personalized correction needs.

[0032] 2. Inverse optimization design method incorporating robustness constraints: The key innovation of this invention lies in the optimized generation In the process, clinical uncertainties were explicitly considered. The optimization model not only included standard imaging quality objective functions (such as maximizing the area under the MTF curve at multiple object distances), but also introduced typical positioning errors that may occur in the ICL within the eye (such as eccentricity within 0.4 mm and rotation within 5°) as a "robust constraint." The optimization algorithm (such as gradient-based algorithms or genetic algorithms) will find an optimal value within the expected range of these errors. This makes the system's imaging performance insensitive to errors, thereby ensuring the stable realization of the designed performance in real clinical scenarios.

[0033] 3. Precise mapping of phase function to physical surface shape and manufacturability design: To achieve phase modulation, it is necessary to Converted to physical height undulations of the ICL material surface This invention employs a precise mapping formula: ,in This formula explicitly defines the working medium as the aqueous humor of the eye, ensuring the accuracy of the phase design. Simultaneously, "manufacturability constraints" are introduced during the optimization phase, such as limiting the minimum feature size (≥5μm to avoid process challenges and excessive scattering under diffraction limits) and the maximum slope (to ensure the coverage of coatings or biocompatible coatings), thereby guaranteeing that the design results can be reliably reproduced by existing or recent micro / nano fabrication processes (such as grayscale lithography and femtosecond laser direct writing).

[0034] 4. Halo suppression and energy management strategies: To reduce nighttime halos that may be caused by phase structure, the present invention... The design incorporates halo suppression strategies. For example, "apodization" is employed to gradually increase the intensity of phase modulation from the center to the edge of the optical region, thereby smoothing the energy distribution of the point spread function (PSF) and reducing secondary bright rings. This strategy is solved collaboratively with the imaging quality objective as part of the optimization goal.

[0035] This example uses a patient with astigmatism and coma to illustrate the complete process of personalized ICL from design to manufacturing.

[0036] Example: Personalized computational optical EDoF and customization of ICL 1. Patient Data Acquisition and Problem Definition: Patient parameters: equivalent spherical lens -4.50D, astigmatism -1.75D, @20°, wavefront aberration measurements showed significant vertical coma.

[0037] Design goals: To fully correct low-order aberrations, partially compensate for vertical coma (target residual coma <0.05μm), and provide continuous high-quality visual acuity from 0.33m (approximately 3.00D additional refractive power) to infinity. The design must be robust to ±0.3mm eccentricity and ±5° rotational errors.

[0038] 2. Computational optical inverse optimization design (corresponding to) Figure 2 process): like Figure 2 As shown, this diagram is the core design logic block diagram of the present invention. Unlike traditional forward design approaches, it achieves the reverse deduction of "target effect → structural form" through reverse optimization, including: Modeling: Create a personalized eye model (including corneal and lens parameters) in optical design software (such as Zemax Optic Studio) and insert a "phase plane" to be optimized to represent the posterior surface of the ICL.

[0039] Optimization variables: The phase surface is expressed as a combination of coefficients of a series of Zernike polynomials, or directly defined as a pixelated phase distribution.

[0040] Objective function: Main objective: To maximize the weighted sum of MTF values ​​at spatial frequencies of 15 cycles / degree and 30 cycles / degree for pupil diameters of 3 mm and 5 mm, given the object distance set {0.33 m, 0.5 m, 1.0 m, 2.0 m, ∞}.

[0041] Constraint 1: Specify Zernike item The coefficient is close to the target value (used to correct defocus, astigmatism, and coma).

[0042] Constraint 2 (Robustness): Create multiple “configurations”, in which different eccentricity (0, 0.2, 0.3 mm) and rotation (0, 3, 5°) errors are applied to the phase surface, requiring that the weighted sum of MTF of all configurations decreases by no more than 10%.

[0043] Constraint 3 (Manufacturability): The equivalent surface slope is calculated by phase gradient, and the maximum slope is limited to <30°; the minimum characteristic period of phase change is set to >10μm.

[0044] Constraint 4 (Halo Suppression): During optimization, the PSF is evaluated, and an upper limit is set for the energy percentage within the ring 1-2 arcmin from the center.

[0045] Optimized Solution: The software employs a combination of built-in global and local optimization algorithms to solve the problem, ultimately outputting the optimal two-dimensional phase distribution. .

[0046] 3. Surface data generation and process preparation: like Figure 4 As shown, Figure 4 Surface morphology of composite wavefront modulated structures Schematic diagram, this diagram is Figure 3 The physical realization scheme of the target phase function transforms abstract phase information into a micrometer-scale machinable physical structure. In the figure, the x and y axes represent the spatial position of the lens surface (unit: mm), and the Z-axis represents the physical height of the microstructure; the morphology transformation follows the formula... ,in The difference in refractive index between the aqueous humor of the human eye and the lens material is used to achieve a precise mapping of phase delay to physical height through this formula; the surface has an irregular undulating morphology, and its structural characteristics directly determine the light refraction law, simultaneously achieving the functions of improving visual clarity and expanding depth of field.

[0047] This section includes the following steps: The optimized result Perform phase unwrapping (if necessary) and 2π modulo operation.

[0048] According to the formula Calculate the physical height distribution. The refractive index of the ICL material is taken as 1.46, and the refractive index of the aqueous humor is taken as 1.336.

[0049] according to The data includes grayscale mask data for grayscale lithography processes, or laser scanning path and energy control files for femtosecond laser direct writing processes.

[0050] 4. Microstructure fabrication (e.g.) Figure 7 (Flowchart shown) Taking nanoimprint transfer technology as an example: Master mold processing: On a silicon or quartz plate, using electron beam lithography or deep ultraviolet lithography combined with etching processes, a master mold is fabricated to resemble the original mold. The corresponding negative relief structure serves as the master mold.

[0051] Flexible mold replication: Replicating a flexible polymer mold from a master mold.

[0052] ICL preform preparation: Provide an ICL polymer preform with a preset front surface curvature.

[0053] Curved surface nanoimprinting: A flexible mold is precisely aligned and attached to the back surface of the ICL preform. Under certain temperature and pressure conditions, the microstructure pattern on the mold is transferred to the surface of the polymer preform.

[0054] Demolding and post-processing: After cooling, the mold is removed, and the composite wavefront modulation structure formed by the transfer is lightly etched by plasma to remove the residual layer. Then, ultra-precision polishing (for non-microstructure areas), cleaning, hydrophilic coating treatment and sterilization are performed.

[0055] 5. Performance Verification (Simulation and Field Testing): Optical simulation verification: The processing parameters (measured or designed surface shape) were re-imported into the eye model for simulation. Results showed that under ideal implantation conditions with no errors, the MTF@30c / deg remained above 0.25 from 0.33m to infinity. After applying ±0.3mm eccentricity and ±5° rotation errors, the MTF decreased by less than 15%, verifying the effectiveness of the robust design. PSF analysis showed that the halo ring intensity was reduced by approximately 50% compared to the traditional diffractive EDoF design.

[0056] Actual testing: The microstructure morphology of the processed ICL surface was examined using a white light interferometer or atomic force microscope to ensure that the surface shape accuracy (RMS error) was less than 50 nm. The defocus MTF curve was measured using a model eye optical system to confirm that it possesses the expected continuous depth-of-focus characteristics.

[0057] like Figure 5 As shown, the curves comparing MTF versus rotational error (robustness verification chart) are used to verify the robust design effect of the present invention. The horizontal axis represents the intraocular rotational error of the lens (range -5° to +5°), and the vertical axis represents the modulation transfer function (MTF) value, characterizing the imaging contrast (maximum value 1.0 is the ideal state). Curve A represents the prior art solution without robustness constraints, which only maintains a high MTF value at 0° rotation, and its performance significantly decreases after slight rotation (such as 2°). Curve B represents the solution of the present invention, which has a flat-top distribution and maintains stable performance within the rotational error range of -3° to +3°, proving that the present invention can reduce the requirements for surgical positioning accuracy and improve the reliability of clinical applications.

[0058] like Figure 6 As shown, the PSF radial energy distribution is compared (halo suppression verification graph). This graph is used to verify the halo suppression effect. The horizontal axis is the radial distance (logarithmic coordinates, unit arcmin), and the vertical axis is the normalized light intensity (logarithmic coordinates). Curve A represents the scheme without a halo suppression strategy, with a significant secondary peak appearing in the 1-2 arcmin region, corresponding to the halo phenomenon in nighttime vision. Curve B represents the scheme of this invention using a phase amplitude gradient strategy, with the secondary peak intensity reduced by more than 50%. Through energy convergence design, it effectively suppresses nighttime glare and improves visual comfort.

[0059] The design and manufacturing process of the ICL described in this invention is highly digitalized and automated, and can be integrated with existing wavefront-guided personalized refractive surgery systems. The hospital provides patient eye data, the design center completes computational optimization and processing file generation in the cloud, and the manufacturing end completes customized production through a flexible micro-nano fabrication line. The technologies involved, such as grayscale lithography and nanoimprint lithography, are mature in the semiconductor and micro-optics fields and have the potential for large-scale production. This invention provides a novel solution for patients who require superior visual quality, especially those troubled by higher-order aberrations or with high demands for night vision.

[0060] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A personalized aberration compensation and depth-of-field fusion implantable contact lens based on computational optical wavefront modulation, characterized in that, The lens body includes a lens with optical refractive power, and a composite wavefront modulation structure is formed on at least one optical surface of the optical region of the lens body; the target phase function corresponding to the composite wavefront modulation structure is... It is a two-dimensional function that at least includes an aberration compensation phase term for compensating for wavefront aberrations of the target eye. and depth-of-field extension phase term used to generate extended depth of focus Wherein, the target phase function The optimization process, determined by computational optical inverse optimization, aims to improve the imaging quality of the eye-ICL combined optical system at multiple preset object distances, while simultaneously using the expected positioning error of the ICL relative to the pupil as a robust constraint.

2. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 1, characterized in that, The composite wavefront modulation structure is composed of an integrated base surface that provides the basic refractive power and a phase modulation microstructure superimposed thereon; the physical height distribution of the phase modulation microstructure With the target phase function The following relationship must be satisfied: ,in, To design the center wavelength, , The refractive index of the material of the lens body is given. The refractive index of the aqueous humor in the eye.

3. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 2, characterized in that, In the computational optics inverse optimization method, the expected positioning error includes at least one of eccentricity, tilt angle, and rotation angle, and is incorporated into the objective function or constraints during the optimization process through Monte Carlo simulation or multi-configuration optimization.

4. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 1, characterized in that, The composite wavefront modulation structure includes a continuous surface shape, a multi-level stepped surface shape, or a discrete phase modulation unit array; the phase modulation unit array is arranged in one of the following ways: concentric rings, non-concentric rings, or a non-periodic arrangement.

5. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 4, characterized in that, The depth-of-field phase term A radially varying energy distribution strategy is employed, which causes the modulation intensity of the phase modulation microstructure to gradually increase or decrease from the optical center to the edge, thereby achieving halo suppression.

6. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 5, characterized in that, The computational optics inverse optimization method also introduces manufacturing process constraints, which include at least one of the following: minimum lateral feature size of the phase modulation microstructure, maximum surface slope angle, or number of surface quantization steps.

7. The implantable contact lens based on computational optical wavefront modulation with personalized aberration compensation and depth-of-field fusion as described in claim 1, characterized in that, The optical area surface of the lens body or the support haptic is provided with positioning marks for intraoperative axial alignment; the aberration compensation phase term It is a non-rotationally symmetric two-dimensional phase distribution, and its main compensation direction is associated with the axis indicated by the positioning mark.

8. A method for preparing the contact lens according to any one of claims 1-7, characterized in that, The method includes the following steps: S1: Acquire wavefront aberration data and corneal topography data of the target eye; S2: Based on the wavefront aberration data, generate an initial aberration compensation phase term. ; S3: Construct a joint optimization model that includes an eyeball optical model, a contact lens substrate model, and a statistical model of expected positioning error; S4: In the joint optimization model, the main objective is to maximize the weighted average value of the modulation transfer function (MTF) under a preset object distance set, with the expected positioning error as a robust constraint, and the depth-of-field extension phase term is obtained through iterative algorithm optimization. This allows for the fusion of the final target phase function. ; S5: According to the target phase function Based on the high mapping relationship described in claim 2, the machinable surface shape data of the composite wavefront modulation structure is generated; S6: Based on the machinable surface data, the composite wavefront modulation structure is formed on a designated optical surface of the ICL substrate.

9. The method according to claim 8, characterized in that, The optimization process in step S4 is performed simultaneously under at least two characteristic pupil diameter conditions, and the chromatic difference at at least two wavelengths is evaluated and constrained.

10. The method according to claim 8 or 9, characterized in that, The processing technology in step S6 is one or more combinations of grayscale mask lithography, femtosecond laser two-photon polymerization direct writing, nanoimprint transfer, or single-point diamond turning.

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