Method and device for determining coronary artery resting blood flow based on individual specificity data

Abstract

The invention discloses a device for determining coronary artery resting blood flow based on individual specificity data. According to the technical scheme, the device is characterized by comprising an image acquisition device, an image analysis device, an individual specificity data acquisition device and a resting blood flow feature calculation device; the image acquisition device is used for acquiring and transmitting a CTA image sequence of an individual; the image analysis device is used for processing the CTA image sequence transmitted by the image acquisition device; the image analysis device is also used for performing three-dimensional reconstruction to obtain a coronary artery three-dimensional model, and calculating and judging the coronary artery dominant type of the individual through the coronary artery three-dimensional model; the individual specificity data acquisition device is used for acquiring, analyzing and storing individual specificity data in the physiological information of the patient; the resting blood flow characteristic calculation device is used for calculating the individual resting blood flow according to the coronary artery dominance type and the individual specificity data, and the accuracy of the resting blood flow calculation result can be improved by combining the individual specificity data.

Description

Technical Field

[0001] This invention relates to the field of medical technology, and more specifically, to a method and apparatus for determining coronary resting blood flow based on individual-specific data. Background Technology

[0002] The fractional flow reserve (FFR) of the coronary arteries is an important indicator for assessing coronary artery stenosis and is also the gold standard for coronary functional examination. FFR testing involves invasive intervention with a pressure guidewire to measure intravascular pressure, which is expensive. In recent years, with the rapid development of computational fluid dynamics, computed tomography-based FFR (CTFFR), calculated from computed tomography angiography (CTA), has gradually emerged and been applied clinically. The non-invasive and safe advantages of CTFFR have garnered widespread attention.

[0003] For a given coronary artery model, the FFR results obtained from computational fluid dynamics simulations are highly dependent on the setting of the inlet and outlet boundary conditions, one of the most important of which is the patient's resting blood flow. Therefore, to accurately calculate FFRCT and make effective clinical decisions, the inlet and outlet boundary conditions should be customized based on patient-specific data and follow the patient's actual physiological state. However, non-invasively determining physiologically specific parameters is very difficult. This is because it is impractical to non-invasively measure accurate boundary conditions, such as flow and pressure, at each coronary artery inlet and outlet; therefore, the inlet and outlet boundary conditions need to be estimated based on patient-specific data, such as age, blood pressure, and medical history. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a device for determining coronary resting blood flow based on individual-specific data. This device can improve the accuracy of resting blood flow calculation results by combining individual-specific data.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a device for determining coronary resting blood flow based on individual-specific data, comprising: an image acquisition device, an image analysis device, an individual-specific data acquisition device, and a resting blood flow characteristic calculation device;

[0006] The image acquisition device is used to acquire and transmit an individual's CTA image sequence;

[0007] The image analysis device is used to process the CTA image sequence transmitted by the image acquisition device;

[0008] The image analysis device is also used to perform three-dimensional reconstruction to obtain a three-dimensional model of the coronary arteries, and to calculate and determine the individual's coronary artery dominance type through the three-dimensional model of the coronary arteries;

[0009] The individual-specific data acquisition device is used to acquire, analyze, and store individual-specific data in the patient's physiological information;

[0010] The resting blood flow characteristic calculation device is used to calculate individual resting blood flow based on coronary artery dominance type and individual-specific data.

[0011] A method for determining coronary resting blood flow based on individual-specific data includes:

[0012] Obtain individual coronary artery CTA imaging sequences;

[0013] A coronal 3D model was obtained by reconstructing a 3D model using CTA image sequences.

[0014] The volume and length of the longest branch of the left and right coronary arteries were calculated using a three-dimensional coronary model, and the coronary artery dominance type of an individual was determined.

[0015] Obtain individual-specific data;

[0016] Based on the coronary dominance pattern and the individual-specific data, the individual resting blood flow was calculated.

[0017] In summary, the present invention has the following beneficial effects: This application performs three-dimensional reconstruction of coronary arteries on CTA images and can calculate and obtain the topological attribute information of coronary vessels, determine the dominant type of coronary arteries, and calculate individual resting blood flow by combining individual-specific data. It comprehensively considers the influence of various factors such as age, gender, and medical history on the calculation of resting blood flow, making the resting blood flow value obtained by the method of determining coronary resting blood flow based on individual-specific data of the present invention more accurate and reliable. Attached Figure Description

[0018] Figure 1 A structural block diagram of a device for determining coronary resting blood flow based on individual-specific data;

[0019] Figure 2 This is a flowchart illustrating a method for determining coronary resting blood flow based on individual-specific data.

[0020] Reference numerals: 1. Image acquisition device; 2. Image analysis device; 3. Individual-specific data acquisition device; 4. Resting blood flow characteristic calculation device. Detailed Implementation

[0021] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Identical components are denoted by the same reference numerals. It should be noted that the terms "front," "rear," "left," "right," "upper," and "lower" used in the following description refer to directions in the accompanying drawings, and the terms "bottom surface," "top surface," "inner," and "outer" refer to directions toward or away from the geometric center of a specific component, respectively.

[0022] Reference Figure 1 and Figure 2 As shown, in order to achieve the above objectives, the present invention provides the following technical solution: a device for determining coronary resting blood flow based on individual-specific data, comprising: an image acquisition device 1, an image analysis device 2, an individual-specific data acquisition device 3, and a resting blood flow characteristic calculation device 4;

[0023] Image acquisition device 1 is used to acquire and transmit an individual's CTA image sequence;

[0024] Image analysis device 2 is used to process the CTA image sequence transmitted by image acquisition device 1;

[0025] Image analysis device 2 is also used to perform three-dimensional reconstruction to obtain a three-dimensional model of the coronary arteries, and to calculate and determine the individual's coronary artery dominance type through the three-dimensional model of the coronary arteries;

[0026] The individual-specific data acquisition device 3 is used to acquire, analyze, and store individual-specific data in the patient's physiological information;

[0027] Individual-specific data include, but are not limited to, individual age, sex, weight, blood pressure, whether they have diabetes, and whether they have a history of smoking.

[0028] The resting blood flow characteristic calculation device 4 is used to calculate individual resting blood flow based on coronary artery dominance type and individual-specific data.

[0029] The resting blood flow characteristic calculation device 4 receives the coronary artery dominance information transmitted by the image analysis device 2 and the individual-specific data transmitted by the individual-specific data acquisition device 3, and calculates the individual resting blood flow using the coronary artery dominance information and the individual-specific data.

[0030] The image acquisition device 1 includes an X-ray emitting device and can generate CTA image sequences.

[0031] The image analysis device 2 is used to obtain the coronary artery dominance pattern. The specific steps include:

[0032] S1. Reconstruct the CTA image sequence to obtain a three-dimensional model of the individual's coronary arteries;

[0033] S2. Determine the individual coronary artery dominance type based on the topological attribute information of the left and right coronary arteries;

[0034] The attribute information of the left and right coronary arteries was obtained through a three-dimensional model of the coronary arteries.

[0035] The topological attribute information includes the volume of the left crown, the length of the longest trunk of the left crown, the volume of the right crown, and the length of the longest trunk of the right crown;

[0036] Topological attribute information is obtained by three-dimensional reconstruction and calculation of the CTA image sequence using image analysis device 2.

[0037] The calculation method for coronary artery dominance is as follows:

[0038]

[0039] I Left =αL Left +βV Left

[0040] I Right =αL Right +βV Right

[0041] Where I is the coronary dominance index, L is the length of the longest branch, V is the volume, and α and β are constants;

[0042] When I ≥ 0.5, it is a left crown-dominant type;

[0043] When I < 0.5, it is a right crown dominance type.

[0044] The method for calculating individual resting blood flow is as follows:

[0045] Q=-0.5Y+0.4P-0.3S+0.2I+0.7*115*(0.2X+1)-0.1D;

[0046] Q represents resting blood flow, Y represents individual age, P represents individual systolic blood pressure, X represents individual gender, S represents individual smoking history, I represents coronary dominance index, and D represents individual diabetes history.

[0047] In X, males are represented by 1 and females by 0;

[0048] In S, smoking is represented by 1, and non-smoking is represented by 0.

[0049] D is 1 for those with diabetes and 0 for those without diabetes.

[0050] A method for determining coronary resting blood flow based on individual-specific data includes:

[0051] Obtain individual coronary artery CTA imaging sequences;

[0052] A coronal 3D model was obtained by reconstructing a 3D model using CTA image sequences.

[0053] The volume and length of the longest branch of the left and right coronary arteries were calculated using a three-dimensional coronary model, and the coronary artery dominance type of an individual was determined.

[0054] Obtain individual-specific data;

[0055] Individual resting blood flow is calculated based on coronary dominance type and individual-specific data.

[0056] In summary, this application performs three-dimensional reconstruction of coronary arteries on CTA images, calculates and obtains the topological attribute information of coronary vessels, determines the dominant type of coronary arteries, and calculates individual resting blood flow by combining individual-specific data. It comprehensively considers the influence of various factors such as age, gender, and medical history on the calculation of resting blood flow, making the resting blood flow value obtained by the method of determining coronary resting blood flow based on individual-specific data of this invention more accurate and reliable.

[0057] The above are merely preferred embodiments of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principle of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. A device for determining coronary resting blood flow based on individual-specific data, characterized in that, It includes: an image acquisition device (1), an image analysis device (2), an individual-specific data acquisition device (3), and a resting blood flow characteristic calculation device (4); The image acquisition device (1) is used to acquire and transmit an individual's CTA image sequence; The image analysis device (2) is used to process the CTA image sequence transmitted by the image acquisition device (1); The image analysis device (2) is also used to perform three-dimensional reconstruction to obtain a three-dimensional model of the coronary artery, and to calculate and determine the individual's coronary artery dominance type through the three-dimensional model of the coronary artery; The individual-specific data acquisition device (3) is used to acquire, analyze and store individual-specific data in the patient's physiological information; The resting blood flow characteristic calculation device (4) is used to calculate individual resting blood flow based on coronary artery dominance type and individual-specific data.

2. The apparatus for determining coronary resting blood flow based on individual-specific data according to claim 1, characterized in that: The image acquisition device (1) includes an X-ray emitting device and can generate CTA image sequences.

3. The device for determining coronary resting blood flow based on individual-specific data according to claim 1, characterized in that: The image analysis device (2) is used to obtain the coronary artery dominance pattern. The specific steps include: S1. Reconstruct the CTA image sequence to obtain a three-dimensional model of the individual's coronary arteries; S2. Determine the individual coronary artery dominance type based on the topological attribute information of the left and right coronary arteries; The attribute information of the left and right coronary arteries is obtained through the three-dimensional model of the coronary arteries.

4. The device for determining coronary resting blood flow based on individual-specific data according to claim 3, characterized in that: The topological attribute information includes the volume of the left crown, the length of the longest trunk of the left crown, the volume of the right crown, and the length of the longest trunk of the right crown; The topological attribute information is obtained by three-dimensional reconstruction and calculation of the CTA image sequence through the image analysis device (2).

5. The apparatus for determining coronary resting blood flow based on individual-specific data of claim 3, wherein: The calculation method for the coronary artery dominance type is as follows: I Left = aL Left + βV Left I Right = aL Right + βV Right Where I is the coronary dominance index, L is the length of the longest branch, V is the volume, and α and β are constants; When I ≥ 0.5, it is a left crown-dominant type; When I < 0.5, it is a right crown dominance type.

6. The apparatus for determining coronary resting blood flow based on individual-specific data of claim 1, wherein: The method for calculating the individual resting blood flow is as follows: Q=-0.5Y+0.4P-0.3S+0.2I+0.7*115*(0.2X+1)-0.1D; Q represents resting blood flow, Y represents individual age, P represents individual systolic blood pressure, X represents individual gender, S represents individual smoking history, I represents coronary dominance index, and D represents individual diabetes history.

7. A method of determining coronary resting blood flow based on individual-specific data, characterized by Including: Obtain individual coronary artery CTA imaging sequences; A coronal 3D model was obtained by reconstructing a 3D model using CTA image sequences. The volume and length of the longest branch of the left and right coronary arteries were calculated using a three-dimensional coronary model, and the coronary artery dominance type of an individual was determined. Obtain individual-specific data; Based on the coronary dominance pattern and the individual-specific data, the individual resting blood flow was calculated.

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