Traditional Chinese medicine composition for invigorating spleen, eliminating dampness, regulating middle warmer, regulating fat and reducing weight as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for invigorating spleen, eliminating dampness, regulating middle warmer, regulating fat and reducing weight, and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 15-25 parts of Zhejiang chrysanthemum morifolium, 12-20 parts of hawthorn, 10-18 parts of lotus leaf, 8-15 parts of pericarpium citri reticulatae, 8-15 parts of poria cocos and 15-25 parts of fried coix seed. Zhejiang Hangzhou white chrysanthemum is taken as a monarch drug, hawthorn is taken as a ministerial drug, lotus leaf and dried orange peel are taken as adjuvant drugs, poria cocos and fried coix seed are taken as conductant drugs, the monarch drug has the effects of clearing heat, calming liver, dissolving turbidity and regulating the middle warmer, the ministerial drug has the effects of promoting digestion, removing food stagnation, dissolving turbidity and removing greasy feeling, the adjuvant drug has the effects of clearing heat, promoting diuresis, regulating qi-flowing for strengthening spleen, and the conductant drug fried coix seed has the effects of strengthening spleen, excreting dampness, inducing diuresis to alleviate edema. The states of internal retention of phlegm-dampness and accumulation of turbid fat are improved, and cooperative regulation and control of body weight and blood fat are realized. According to the invention, a multi-target compound system is constructed by taking the concept of'strengthening spleen, eliminating dampness and regulating the middle warmer 'in traditional Chinese medicine as a core, and is suitable for daily health management of crowds with excessive phlegm-dampness and tendency to implication of turbid lipid.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for invigorating the spleen, resolving dampness, regulating lipids, and reducing weight, as well as its preparation method and application. Background Technology

[0002] With the accelerated pace of modern life and the Westernization of dietary structures (increased intake of high-oil, high-fat, and high-sugar foods), the proportion of people with phlegm-dampness constitution is increasing year by year. This group often presents with overweight, heaviness in the limbs, abdominal distension, and loose stools, accompanied by abnormal lipid metabolism, specifically elevated total cholesterol, triglycerides, and low-density lipoprotein cholesterol, and decreased high-density lipoprotein cholesterol. Overweight and abnormal blood lipids interact and have become a significant contributing factor to chronic metabolic diseases such as atherosclerosis, coronary heart disease, and fatty liver, seriously threatening public health.

[0003] Currently, commonly used clinical methods for lipid regulation and weight loss include chemotherapy and lifestyle interventions. However, chemotherapy drugs have side effects such as liver and kidney damage and gastrointestinal reactions, and their long-term safety is questionable. Lifestyle interventions alone suffer from poor adherence and slow effectiveness. Traditional Chinese medicine believes that the core pathogenesis of excessive phlegm and dampness and internal accumulation of turbid fat is spleen and stomach dysfunction, internal generation of dampness and turbidity, qi stagnation, and food stagnation. "Strengthening the spleen, resolving dampness, and harmonizing the middle jiao" is the key treatment principle. Existing Chinese herbal medicine compositions mostly focus on a single effect (either weight loss or lipid regulation), lacking a comprehensive system that addresses the core pathogenesis of "phlegm-dampness-turbid fat" and integrates "resolving turbidity and greasiness, strengthening the spleen and resolving dampness, regulating qi and harmonizing the middle jiao, and promoting digestion and relieving stagnation." Moreover, they are mostly targeted at clinical obese patients, and their suitability for daily management populations is insufficient. Therefore, developing a safe, effective, and suitable Chinese herbal medicine composition for lipid regulation and weight loss based on traditional Chinese medicine theory is of significant practical importance. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, harmonizing the middle jiao, regulating lipids, and reducing weight, as well as its preparation method and application, to solve the problems existing in the prior art. Based on the traditional Chinese medicine concept of "strengthening the spleen, resolving dampness, and harmonizing the middle jiao", a multi-target compound system is constructed to suit the daily health management of people with excessive phlegm and dampness and internal accumulation of turbid lipids.

[0005] To achieve the above objectives, the present invention provides the following solution: This invention provides a traditional Chinese medicine composition for strengthening the spleen, resolving dampness, regulating the middle jiao, and promoting weight loss. By weight, the composition comprises the following raw materials: 15-25 parts of Zhejiang-produced Hangzhou white chrysanthemum, 12-20 parts of hawthorn, 10-18 parts of lotus leaf, 8-15 parts of dried tangerine peel, 8-15 parts of Poria cocos, and 15-25 parts of stir-fried coix seed. Further, the weight ratio of Zhejiang-produced Hangzhou white chrysanthemum to stir-fried coix seed is 1:1, and the two synergistically enhance the core effects of "strengthening the spleen, resolving dampness, and harmonizing the middle jiao."

[0006] Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 18-22 parts of Zhejiang-produced Hangzhou white chrysanthemum, 14-18 parts of hawthorn, 12-16 parts of lotus leaf, 10-13 parts of dried tangerine peel, 10-13 parts of poria cocos, and 18-22 parts of stir-fried coix seed.

[0007] Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of Zhejiang-produced Hangzhou white chrysanthemum, 16 parts of hawthorn, 14 parts of lotus leaf, 12 parts of dried tangerine peel, 12 parts of poria cocos, and 20 parts of stir-fried coix seed.

[0008] The above-mentioned herbal composition follows the principles of traditional Chinese medicine regarding the compatibility of principal, assistant, adjuvant, and guide herbs: The principal ingredient is Hangzhou white chrysanthemum from Zhejiang (a genuine medicinal material). It has a sweet and bitter taste and is slightly cold in nature. It enters the lung and liver meridians. It clears heat and calms the liver, resolves turbidity and harmonizes the middle jiao, and also clears phlegm and dampness and regulates qi. The assistant ingredient: hawthorn, which is sour and sweet in taste and slightly warm in nature, enters the spleen, stomach and liver meridians. It promotes digestion, eliminates stagnation, and removes turbidity and greasiness. It is especially effective for greasy food and helps reduce turbidity and lipids. The adjuvant herbs are lotus leaf and dried tangerine peel. Lotus leaf is bitter and sweet in taste and neutral in nature. It enters the liver, spleen and stomach meridians. It clears heat and promotes diuresis, raises clear yang, and helps the principal herb to resolve dampness. Dried tangerine peel is pungent, sweet and bitter in taste and warm in nature. It enters the spleen and lung meridians. It regulates qi and strengthens the spleen, dries dampness and resolves phlegm, and harmonizes the qi mechanism of the spleen and stomach. The guiding herbs are Poria cocos and stir-fried Coix lacryma-jobi. Poria cocos is sweet and bland in taste and neutral in nature. It enters the heart, spleen, and kidney meridians. It strengthens the spleen, eliminates dampness, calms the mind, and soothes the nerves. Stir-fried Coix lacryma-jobi is sweet and bland in taste and cool in nature. It enters the spleen, stomach, and lung meridians. It strengthens the spleen, eliminates dampness, promotes diuresis, and reduces swelling. The two herbs enhance the spleen-strengthening and dampness-eliminating effects and guide the other herbs directly to the affected area.

[0009] When used together, these herbs form a progressive system of action: "resolving turbidity and greasiness → strengthening the spleen and eliminating dampness → regulating qi and harmonizing the middle jiao → promoting digestion and relieving stagnation." Starting from regulating the function of the spleen and stomach, it improves the state of phlegm and dampness retention and turbid fat accumulation, achieving synergistic regulation of weight and blood lipids. Moreover, the herbs are mild and suitable for long-term daily use.

[0010] The present invention also provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps: After pretreatment, the various Chinese herbal raw materials are mixed and pulverized to obtain a mixture. The mixture is mixed with water and subjected to vacuum reflux extraction, and the extract is collected. The conditions for vacuum reflux extraction are: temperature 78-88℃, pressure 8-16KPa, time 50-80min, and extraction times 1-3 times. The extract was filtered, concentrated under reduced pressure, and then spray-dried to obtain the traditional Chinese medicine composition.

[0011] The optimal temperature for the above-mentioned reduced pressure reflux extraction is 22℃ and the optimal pressure is 10KPa. Under these conditions, the extraction rate of active ingredients is increased by 15%-20% compared with other parameters.

[0012] Preferably, the pretreatment is as follows: after removing impurities and washing each Chinese herbal raw material, it is dried in an oven at 50-60℃ for 3-5 hours.

[0013] Preferably, the mass-to-volume ratio of the mixture to water is 1g:8-12mL.

[0014] Preferably, the conditions for vacuum concentration are: temperature 45-55℃, pressure 15-25KPa; and the conditions for spray drying are: inlet air temperature 160-180℃, outlet air temperature 80-90℃.

[0015] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of drugs for regulating lipids and reducing weight.

[0016] Preferably, the drug is used to regulate blood lipids and weight in individuals with excessive phlegm and dampness and turbid lipids.

[0017] This invention also provides a drug for regulating lipids and reducing weight, the drug containing the aforementioned traditional Chinese medicine composition. The above-mentioned drug can be formulated into various dosage forms such as granules, liquids, tablets, and capsules.

[0018] The present invention discloses the following beneficial effects: (1) Scientific formulation, multi-target synergistic lipid regulation and weight loss This invention is based on the core theory of "strengthening the spleen, resolving dampness, and harmonizing the middle jiao" in Traditional Chinese Medicine. Following the principles of monarch-minister-assistant-guide drug combination, it selects six authentic medicinal herbs from Zhejiang: Hangzhou white chrysanthemum, hawthorn, lotus leaf, tangerine peel, poria cocos, and stir-fried coix seed. It constructs a progressive action system of "resolving turbidity and greasiness → strengthening the spleen and resolving dampness → regulating qi and harmonizing the middle jiao → promoting digestion and relieving stagnation." The monarch herb (Hangzhou white chrysanthemum) clears heat, calms the liver, resolves turbidity, and harmonizes the middle jiao; the assistant herb (hawthorn) promotes digestion, resolves turbidity, and relieves greasiness; the adjuvant herbs (lotus leaf and tangerine peel) clear heat, promote diuresis, regulate qi, and strengthen the spleen; and the guide herbs (poria cocos and stir-fried coix seed) strengthen the spleen, eliminate dampness, and reduce swelling. The combined effect of these six herbs, starting with regulating spleen and stomach function, improves the state of phlegm-dampness retention and turbid lipid accumulation, achieving synergistic regulation of weight and blood lipids.

[0019] (2) Excellent weight loss effect The herbal composition of this invention can significantly inhibit weight gain in a high-fat induced obesity model and has excellent weight loss effects. It is especially suitable for the daily weight management of people with excessive phlegm and dampness and a tendency to accumulate turbid fat.

[0020] (3) Significant lipid-regulating effect The traditional Chinese medicine composition of this invention can effectively improve blood lipid indicators (total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol), and has a comprehensive and significant regulatory effect on blood lipid abnormalities induced by a high-fat diet.

[0021] (4) Technological innovation, effectively retaining active ingredients This invention employs a reduced pressure reflux extraction process, which involves extraction at 78-88℃ and 8-16KPa. This avoids the damage of heat-sensitive active ingredients to high temperatures, maximizing the retention of the active ingredients in each component and enhancing product efficacy.

[0022] (5) It has mild medicinal properties and is suitable for long-term daily use. This invention primarily uses medicinal herbs that are also used in food, resulting in a mild formula without the liver and kidney damage, gastrointestinal reactions, or other side effects associated with chemical drugs. Rat experiments have verified that no significant adverse reactions were observed after 8 weeks of continuous administration, demonstrating high safety. It is particularly suitable for long-term daily health management in individuals with predominantly phlegm-dampness and a tendency towards internal accumulation of turbid fat.

[0023] (6) It has diverse application forms to meet different needs. The traditional Chinese medicine composition of this invention can be prepared into various dosage forms such as granules, liquids, tablets, and capsules as needed to meet the needs of different groups of people in terms of their taking habits and usage scenarios, and is easy to promote and apply. Detailed Implementation

[0024] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0025] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0026] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0027] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be obvious to those skilled in the art. This specification and embodiments are merely exemplary.

[0028] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0029] All raw materials used in this invention are commercially available authentic medicinal herbs, and the preparation equipment is conventional Chinese medicine processing equipment. Operations without specific conditions are carried out according to conventional processes.

[0030] Example 1: A traditional Chinese medicine composition for invigorating the spleen, resolving dampness, harmonizing the middle jiao, regulating lipids, and reducing weight, and its preparation method. The components of the traditional Chinese medicine composition by weight are: 20 parts of Zhejiang-produced Hangzhou white chrysanthemum, 16 parts of hawthorn, 14 parts of lotus leaf, 12 parts of dried tangerine peel, 12 parts of poria cocos, and 20 parts of stir-fried coix seed.

[0031] The preparation method involves the following steps: (1) Raw material pretreatment: Remove impurities from each component, wash and dry in an oven at 60℃ for 4 hours; (2) Mixing and crushing: After mixing in proportion, crush to 100 mesh to obtain a mixture; (3) Reduced pressure reflux extraction: Add 10 times the volume of water to the mixture (i.e., the mass-volume ratio of the mixture to water is 1g:10mL), and reflux extract twice at a temperature of 78℃ and a pressure of 10KPa, each time for 65min, and combine the extracts; (4) Concentration and drying: The extract was filtered and concentrated under reduced pressure at 48°C and 20KPa to a paste with a relative density of 1.22. Then it was spray-dried (inlet air temperature 170°C, outlet air temperature 85°C) to obtain a dry powdered Chinese medicine composition.

[0032] Example 2: A traditional Chinese medicine composition for invigorating the spleen, resolving dampness, harmonizing the middle jiao, regulating lipids, and reducing weight, and its preparation method. The components of the traditional Chinese medicine composition by weight are: 15 parts of Zhejiang-produced Hangzhou white chrysanthemum, 12 parts of hawthorn, 10 parts of lotus leaf, 8 parts of dried tangerine peel, 8 parts of poria cocos, and 15 parts of stir-fried coix seed.

[0033] Preparation method: (1) Raw material pretreatment: Remove impurities from each component, wash and dry in an oven at 60℃ for 4 hours; (2) Mixing and grinding: After mixing in proportion, grind the mixture to 80 mesh to obtain a mixture; (3) Reduced pressure reflux extraction: Add 8 times the volume of water to the mixture (i.e., the mass-volume ratio of the mixture to water is 1g:8mL), and reflux extract once at a temperature of 83℃ and a pressure of 8KPa for 80min. (4) Concentration and drying: Concentrate at 50℃ and 15KPa to a relative density of 1.20, and spray dry (inlet air temperature 160℃, outlet air temperature 80℃) to obtain a dry powdered Chinese medicine composition.

[0034] Example 3: A traditional Chinese medicine composition for invigorating the spleen, resolving dampness, regulating the middle jiao, and reducing fat and its preparation method. The components of the traditional Chinese medicine composition by weight are: 25 parts of Zhejiang-produced Hangzhou white chrysanthemum, 20 parts of hawthorn, 18 parts of lotus leaf, 15 parts of dried tangerine peel, 15 parts of poria cocos, and 25 parts of stir-fried coix seed.

[0035] Preparation method: (1) Raw material pretreatment: Remove impurities from each component, wash and dry in an oven at 60℃ for 4 hours; (2) Mixing and grinding: After mixing in proportion, grind the mixture to 90 mesh to obtain a mixture; (3) Reduced pressure reflux extraction: Add 12 times the volume of water to the mixture (i.e., the mass-volume ratio of the mixture to water is 1g:12mL), and reflux extract 3 times at a temperature of 88℃ and a pressure of 16KPa for 50min. Combine the extracts. (4) Concentration and drying: Concentrate at 55℃ and 25KPa to a relative density of 1.25, and spray dry (inlet air temperature 180℃, outlet air temperature 90℃) to obtain a dry powdered Chinese medicine composition.

[0036] Comparative Example 1 The only difference from Example 1 is that hawthorn was not added, while the proportions of the remaining components and the preparation methods are the same.

[0037] Comparative Example 2 The only difference from Example 1 is that no roasted Job's tears were added; the proportions of the other components and the preparation methods and steps are the same.

[0038] Comparative Example 3 The only difference from Example 1 is that the vacuum reflux extraction is changed to atmospheric reflux extraction (temperature 100℃, atmospheric pressure), while the proportions of other components and the preparation methods are the same.

[0039] animal experiments This experiment verified the lipid-regulating and weight-loss effects of the traditional Chinese medicine compositions obtained in Examples 1-3 and Comparative Examples 1-3, as detailed below: 1. Experimental animals: 60 male SPF-grade SD rats, weighing 200±10g, were purchased from the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine and were acclimatized for 7 days.

[0040] 2. Model Establishment: Sixty rats were randomly divided into two groups: a normal group (n=10, fed with standard diet) and a model group (n=50, fed with high-fat diet; high-fat diet formula: 78.8% basal diet, 10% lard, 10% egg yolk powder, 1% cholesterol, and 0.2% sodium cholate). During the feeding period, rats had free access to food and water, and their body weight was measured weekly. After 6 weeks of feeding, rats in the model group were considered to have successfully established a model if their body weight increased by ≥20% compared to the normal group, and their serum total cholesterol (TC) was ≥5.0 mmol / L and triglycerides (TG) were ≥1.8 mmol / L.

[0041] 3. Grouping and Administration: Forty-nine rats that successfully developed the model were randomly divided into seven groups (n=7 per group): Model group (high-fat diet + saline by gavage), Administration groups 1-3 (high-fat diet + suspension of the herbal composition from Examples 1-3 by gavage), and Control groups 1-3 (high-fat diet + suspension of the herbal composition from Examples 1-3 by gavage). The normal control group continued to be fed a normal diet + saline by gavage. The gavage dose was 0.5 g / kg / day, administered once daily at 9:00 AM for 8 consecutive weeks.

[0042] 4. Detection indicators: (1) Body weight: The body weight of rats was measured at 0 and 8 weeks after intervention; (2) Blood lipid indicators: After 8 weeks of intervention, rats were fasted for 12 hours, blood was collected from the abdominal aorta, serum was separated by centrifugation, and TC, TG, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected by a fully automated biochemical analyzer.

[0043] 5. Results and Analysis The test results are shown in Tables 1-2.

[0044] Table 1. Changes in body weight of rats in each group (x±s, g) Note: Weight gain inhibition rate = (weight gain value of model group - weight gain value of test group) / weight gain value of model group × 100%, where test group refers to the drug administration group or control group.

[0045] Table 2. Results of serum lipid levels in rats of each group (x±s, mmol / L) Based on the above data, it can be seen that (1) in terms of weight: the weight gain of rats in the model group was significantly higher than that in the normal group (P<0.01); the weight gain of groups 1-3 was significantly lower than that in the model group and control groups 1-3 (P<0.01), among which the weight gain inhibition rate of Example 1 was the highest (49.4%), which was close to the weight level of the normal group, indicating that the Chinese medicine composition of the present invention has excellent weight loss effect, and the optimal formula (Example 1) has the best effect. (2) in terms of blood lipids: the TC, TG, and LDL-C of rats in the model group were significantly increased, and the HDL-C was significantly decreased (P<0.01), which is consistent with the characteristics of the blood lipid abnormality model; the TC, TG, and LDL-C of groups 1-3 were significantly lower than those in the model group and control groups 1-3 (P<0.01), and the HDL-C was significantly higher than those in the model group and control groups 1-3 (P<0.01), among which the blood lipid index of Example 1 was closest to that of the normal group, indicating that the Chinese medicine composition of the present invention can effectively improve blood lipid metabolism disorder. (3) Comparative analysis: The lipid-regulating and weight-loss effects of comparative example 1 (lacking hawthorn) and comparative example 2 (lacking roasted coix seed) were significantly reduced, indicating that the "clearing turbidity and relieving greasiness" of hawthorn and the "strengthening the spleen and removing dampness" of roasted coix seed are the key to the core efficacy of the compound; the effect of comparative example 3 (normal pressure extraction) was reduced, indicating that the depressurized reflux extraction process of the present invention can better retain active ingredients and improve efficacy.

[0046] In summary, the traditional Chinese medicine composition provided by this invention, through scientific formulation and optimized process, exhibits excellent effects in regulating lipids and reducing weight. Moreover, it is mild in nature and highly safe, providing a novel daily management method based on traditional Chinese medicine theory for people with excessive phlegm and dampness and a tendency to accumulate turbid fat, and has broad application prospects.

[0047] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for strengthening the spleen, removing dampness, regulating fat and reducing weight, characterized in that, The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in the following amounts by weight: 15-25 parts of Zhejiang-produced Hangzhou white chrysanthemum, 12-20 parts of hawthorn, 10-18 parts of lotus leaf, 8-15 parts of dried tangerine peel, 8-15 parts of poria cocos, and 15-25 parts of stir-fried coix seed.

2. The traditional Chinese medicine composition as described in claim 1, characterized in that, The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in the following amounts by weight: 18-22 parts of Zhejiang-produced Hangzhou white chrysanthemum, 14-18 parts of hawthorn, 12-16 parts of lotus leaf, 10-13 parts of dried tangerine peel, 10-13 parts of poria cocos, and 18-22 parts of stir-fried coix seed.

3. The traditional Chinese medicine composition as described in claim 2, characterized in that, The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 20 parts of Zhejiang-produced Hangzhou white chrysanthemum, 16 parts of hawthorn, 14 parts of lotus leaf, 12 parts of dried tangerine peel, 12 parts of poria cocos, and 20 parts of stir-fried coix seed.

4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, Includes the following steps: After pretreatment, the various Chinese herbal raw materials are mixed and pulverized to obtain a mixture. The mixture is mixed with water and subjected to vacuum reflux extraction, and the extract is collected. The conditions for vacuum reflux extraction are: temperature 78-88℃, pressure 8-16KPa, time 50-80min, and extraction times 1-3 times. The extract was filtered, concentrated under reduced pressure, and then spray-dried to obtain the traditional Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that, The pretreatment involves removing impurities from each Chinese herbal raw material, washing it, and then drying it in an oven at 50-60℃ for 3-5 hours.

6. The preparation method according to claim 4, characterized in that, The mass-to-volume ratio of the mixture to water is 1g:8-12mL.

7. The preparation method according to claim 4, characterized in that, The conditions for vacuum concentration are: temperature 45-55℃, pressure 15-25KPa; the conditions for spray drying are: inlet air temperature 160-180℃, outlet air temperature 80-90℃.

8. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a drug for regulating lipids and reducing weight.

9. The application as described in claim 8, characterized in that, The drug is used to regulate blood lipids and weight in people with excessive phlegm and dampness and turbid lipids.

10. A drug for regulating lipids and reducing weight, characterized in that, The drug contains the traditional Chinese medicine composition according to any one of claims 1-3.

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