Anti-hair loss and hair growth composition and preparation method thereof

Abstract

The invention discloses an anti-hair loss and hair growth composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition takes natural active ingredients as a core and mild auxiliary materials as auxiliary materials, and specifically comprises a cacumen biotae extract, a ginger extract, an eclipta alba extract, a glossy privet fruit extract, a white mulberry root-bark extract, a garden balsam stem extract, a ginseng extract, panthenol and auxiliary materials such as a humectant, an emulsifier and a preservative. All the components have a synergistic effect and can effectively inhibit hair follicle atrophy, promote hair follicle blood circulation and enhance hair follicle activity, so that the effects of preventing alopecia and promoting hair growth are achieved; and the selected raw materials are low-toxicity or medicinal and edible medicinal materials, are high in biological safety after purification treatment, are free of irritation and are suitable for various head skins. The invention further discloses a preparation method of the composition, the steps are simple and controllable, the production cost is low, and industrial production is easy.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine compositions, and in particular to a hair loss prevention and hair growth composition and its preparation method. Background Technology

[0002] With the fast pace of life, increased work pressure, and environmental factors, hair loss has become a common problem troubling many people, affecting not only personal image but also potentially mental health. Currently, the market offers a wide variety of hair loss prevention and regrowth products, mainly including chemically synthesized and natural ingredients.

[0003] While chemically synthesized hair loss prevention and hair regrowth products may have some short-term effects, they often suffer from strong irritation and significant side effects. Long-term use may damage the scalp and hair follicles, and even cause adverse reactions such as allergies. Existing natural ingredient-based hair loss prevention and hair regrowth products mostly suffer from drawbacks such as limited effective ingredients, simple mechanisms of action, and poor hair loss prevention and regrowth effects, failing to meet consumer needs.

[0004] Therefore, developing a composition with natural, mild, non-irritating ingredients and significant hair loss prevention and hair regrowth effects has important market value and application prospects. Summary of the Invention

[0005] In response to the problems of strong irritation, significant side effects, and poor efficacy of existing anti-hair loss and hair regrowth products, this invention provides an anti-hair loss and hair regrowth composition and its preparation method. This composition uses natural active ingredients as its core, is mild and non-irritating, and can synergistically exert anti-hair loss and hair regrowth effects, with significant results.

[0006] To achieve the above objectives, the present invention provides a hair loss prevention and hair growth composition, comprising the following components by weight percentage: 5-30% active ingredient, 5-20% moisturizer, 1-5% emulsifier, 0.1-1% preservative, and the balance being deionized water; By weight percentage, the active ingredients include 10-20% Platycladus orientalis leaf extract, 8-15% ginger extract, 10-20% Eclipta prostrata extract, 8-15% Ligustrum lucidum extract, 5-10% Morus alba root bark extract, 5-10% Clematis chinensis extract, 5-10% ginseng extract, and 5-10% panthenol.

[0007] Arborvitae leaf extract: Contains active ingredients such as flavonoids and terpenes, which have antibacterial and anti-inflammatory effects, inhibit hair follicle atrophy, reduce damage to hair follicles caused by scalp inflammation, and prevent hair loss.

[0008] Ginger extract: Contains gingerol and other ingredients that can promote scalp blood circulation, provide sufficient nutrition to hair follicles, enhance hair follicle activity, and promote hair growth.

[0009] Eclipta prostrata extract: Contains ingredients such as wedelia lactone and demethylwedelia lactone. Traditional Chinese medicine believes that it can nourish yin and kidney, cool blood and stop bleeding. Modern pharmacological studies have shown that it can promote the proliferation of hair follicle papilla cells and inhibit hair follicle apoptosis. Moreover, it is a medicinal and edible material with high safety.

[0010] Ligustrum lucidum extract: Contains oleanolic acid, ursolic acid and other components. When combined with Eclipta prostrata, it can synergistically nourish yin and benefit the kidneys. Modern research has confirmed that it can regulate the scalp microenvironment, inhibit 5α-reductase activity, reduce dihydrotestosterone production, prevent hair follicle miniaturization, and has no obvious toxic side effects.

[0011] Mulberry bark extract: Contains morin, morinol, and other components, which can inhibit 5α-reductase and has anti-inflammatory and moisturizing effects. It can relieve scalp sensitivity and its safety has been verified by long-term clinical trials.

[0012] Herba Clematis chinensis extract: Contains volatile oils and flavonoids, which can promote scalp blood circulation, enhance the transdermal absorption of active ingredients, and have anti-inflammatory and antipruritic effects without irritating the scalp.

[0013] Ginseng extract: Contains ginsenosides and other components, which have antioxidant and anti-aging effects. It can protect hair follicle cells, delay hair follicle aging, and promote the proliferation of hair papilla cells, which is beneficial to hair growth.

[0014] Panthenol: It can penetrate deep into the hair follicles to provide nutrients to the hair, repair damaged hair and hair follicles, and at the same time has a moisturizing effect, improving the condition of dry scalp.

[0015] Preferably, the active ingredient has a weight percentage of 15-25%.

[0016] Preferably, the moisturizer is selected from one or more combinations of glycerin, propylene glycol, and hyaluronic acid.

[0017] Preferably, the emulsifier is selected from one or more combinations of cetearyl alcohol polyether-25, stearyl alcohol polyether-2, and Tween 80.

[0018] Preferably, the preservative is selected from one or more combinations of phenoxyethanol, methylparaben, and chlorphenesin.

[0019] The moisturizer is selected from one or more combinations of glycerin, propylene glycol, and hyaluronic acid, which can retain moisture in the scalp and hair, prevent dryness and itching of the scalp, and provide a good growth environment for hair follicles. The emulsifier is selected from one or more combinations of cetearyl alcohol polyether-25, stearyl alcohol polyether-2, and Tween 80, which can fully mix the oil phase and water phase in the composition to form a stable emulsion system. The preservative is selected from one or more combinations of phenoxyethanol, methylparaben, and chlorphenesin, which can effectively inhibit the growth and reproduction of microorganisms in the composition and extend the shelf life of the product.

[0020] On the other hand, the present invention provides a method for preparing the above-mentioned anti-hair loss and hair growth composition, comprising the following steps: S1. Raw material pretreatment: After crushing the arborvitae leaves, ginger, eclipta prostrata, privet fruit, mulberry bark, clematis root, and ginseng, the effective components were extracted by ethanol reflux extraction. The extract was purified by macroporous resin, filtered, and concentrated to obtain the corresponding extracts for later use. S2. Aqueous phase preparation: Add deionized water to the reactor, heat to 70-80℃, add humectant and preservative in sequence, stir until completely dissolved, and keep warm for 30 minutes. S3. Oil phase preparation: In a separate container, add the emulsifier, heat to 75-85℃, and stir until melted and uniform; S4. Emulsification and mixing: Slowly add the oil phase to the water phase while stirring. The stirring speed is 300-500 r / min and the stirring time is 20-30 min. Then cool down to 45-55℃. S5. Add active ingredients: Add the pretreated raw materials from S1 and panthenol to the above mixture and stir until homogeneous; S6. Finished product: Continue cooling to room temperature, filter, and after passing inspection, the hair loss prevention and hair growth composition is obtained.

[0021] Preferably, the ethanol concentration is 60-80%, the material-to-liquid ratio is 1:10-1:20, the extraction temperature is 70-85℃, the extraction time is 2-4 hours, and the extraction is performed 2-3 times.

[0022] Preferably, after emulsification and mixing in S4, homogenization is performed at a pressure of 20-30 MPa for a time of 5-10 min.

[0023] Preferably, in S5, the stirring speed is 200-300 r / min and the stirring time is 15-20 min.

[0024] Therefore, the hair loss prevention and hair growth composition and preparation method of the present invention have the following beneficial effects: (1) The hair loss prevention and hair growth composition of the present invention combines a variety of natural Chinese herbal extracts, which work synergistically through multiple pathways such as inhibiting hair follicle apoptosis, regulating the scalp microenvironment, promoting blood circulation, and protecting hair follicle cells. The hair loss prevention and hair growth effects are better than those of single-ingredient products.

[0025] (2) All the raw materials selected are medicinal and edible materials or low-toxicity medicinal materials, and the extract is purified by macroporous resin to remove harmful impurities such as tannins and heavy metals; the product is verified by toxicological tests to be non-irritating and non-sensitizing to all types of scalp skin, including sensitive skin.

[0026] (3) The preparation method of the present invention is simple and controllable, with low production cost and good market application prospects.

[0027] The technical solution of the present invention will be further described in detail below through embodiments. Detailed Implementation

[0028] The technical solution of the present invention will be further illustrated by the following embodiments.

[0029] To make the objectives, technical solutions, and advantages of this application clearer, more thorough, and more complete, the technical solutions of the present invention are clearly and completely described below through embodiments. The following detailed descriptions are all illustrations of embodiments, intended to provide further detailed explanations of the present invention. Unless otherwise specified, all technical terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains.

[0030] The instruments, equipment, reagents, and materials used in the examples were all obtained commercially.

[0031] Example 1 A hair loss prevention and hair growth composition, by weight percentage, comprises: 15% active ingredient, 10% glycerin, 2% cetearyl alcohol polyether-25%, 0.5% phenoxyethanol, and the balance being deionized water. Among the active ingredients are 15% Platycladus orientalis leaf extract, 10% ginger extract, 18% Eclipta prostrata extract, 12% Ligustrum lucidum extract, 8% Morus alba root bark extract, 7% Clematis chinensis extract, 8% ginseng extract, and 12% panthenol.

[0032] The preparation method is as follows: S1. Raw material pretreatment: The leaves of Platycladus orientalis, ginger, Eclipta prostrata, Ligustrum lucidum, Morus alba root bark, Clematis chinensis, and ginseng were pulverized separately and the effective components were extracted by reflux extraction with 70% ethanol. The material-to-liquid ratio was 1:15, the extraction temperature was 80℃, the extraction time was 3h, and the extraction was repeated twice. The extract was purified by AB-8 macroporous resin with a loading flow rate of 1.5 BV / h and 70% ethanol as the eluent at a flow rate of 1.5 BV / h. After filtration and concentration, the corresponding extracts were obtained.

[0033] S2. Aqueous phase preparation: Add deionized water to the reactor, heat to 75°C, add glycerol and phenoxyethanol in sequence, stir until completely dissolved, and keep warm for 30 minutes.

[0034] S3. Oil phase preparation: In a separate container, add cetearyl alcohol polyether-25, heat to 80°C, and stir until melted and uniform.

[0035] S4. Emulsification and mixing: Slowly add the oil phase to the water phase while stirring at a speed of 400 r / min for 25 min. Then, homogenize the mixture at a pressure of 25 MPa for 8 min and cool it down to 50℃.

[0036] S5. Add active ingredients: Add the pretreated plant extract and panthenol to the above mixture, stir evenly at a speed of 250 r / min for 18 min.

[0037] S7. Finished product: Continue cooling to room temperature, filter, and after passing inspection, the hair loss prevention and hair growth composition is obtained.

[0038] Example 2 A hair loss prevention and hair growth composition, by weight percentage, comprises: 25% active ingredient, 15% propylene glycol, 23% stearyl alcohol polyether, 0.8% methylparaben, and the balance being deionized water. Among the active ingredients are 12% Platycladus orientalis leaf extract, 8% ginger extract, 20% Eclipta prostrata extract, 15% Ligustrum lucidum extract, 10% Morus alba root bark extract, 10% Clematis chinensis extract, 5% ginseng extract, and 10% panthenol.

[0039] The preparation method is basically the same as that in Example 1, except that: in S1, the ethanol concentration is 80%, the material-liquid ratio is 1:20, the extraction temperature is 85℃, and the extraction time is 4h; in S4, the stirring speed is 500r / min, the stirring time is 30min, the homogenization pressure is 30MPa, and the homogenization time is 10min.

[0040] Example 3 A hair loss prevention and hair growth composition, by weight percentage, comprises: 20% active ingredients, 8% hyaluronic acid, 4% Tween 80, 0.3% chlorphenesin, and the balance being deionized water. Among the active ingredients are 20% Platycladus orientalis leaf extract, 15% ginger extract, 10% Eclipta prostrata extract, 8% Ligustrum lucidum extract, 5% Morus alba root bark extract, 5% Clematis chinensis extract, 10% ginseng extract, and 7% panthenol.

[0041] The preparation method is basically the same as that in Example 1, except that: in S1, the ethanol concentration is 60%, the material-liquid ratio is 1:10, the extraction temperature is 70℃, and the extraction time is 2h; in step 4, the stirring speed is 300r / min, the stirring time is 20min, the homogenization pressure is 20MPa, and the homogenization time is 5min.

[0042] Example 1 Eighty volunteers aged 20-50 years who met the diagnostic criteria for androgenetic alopecia or telogen effluvium were selected, including 45 men and 35 women, with a hair loss duration of 6 months to 5 years. Patients with scalp inflammation, infection, autoimmune diseases, and those who had used other hair loss prevention products or medications in the past 3 months were excluded.

[0043] Volunteers were randomly divided into 4 groups of 20 each using a random number table. There were no statistically significant differences in baseline data such as gender, age, type of hair loss, and duration of disease among the groups. P>0.05), indicating comparability. The specific groups are as follows: Experimental group 1 (using the composition of Example 1 of the present invention), Experimental group 2 (using the composition of Example 2 of the present invention), Experimental group 3 (using the composition of Example 3 of the present invention), and control group (using commercially available conventional anti-hair loss shampoo containing ketoconazole).

[0044] After cleansing their scalps daily, all participants applied the corresponding product evenly to their scalps and massaged for 3-5 minutes, once daily for 3 consecutive months. During the experiment, participants avoided using other products that might affect their scalp condition and maintained regular sleep and diet.

[0045] Evaluation indicators and testing methods: (1) Hair loss detection: At week 0 (baseline), week 4, week 8 and week 12 of the experiment, the amount of hair loss was recorded by hair loss counting method (collecting the number of hairs lost in 24 hours) and hair combing test (combing the hair 10 times with a standard comb and counting the hairs that fell out).

[0046] (2) New hair growth related indicators: The hair loss area on the top of the head was observed using a trichoscope, and the density of new hair growth (per cm²) was measured at baseline and at week 12. 2 The number of new hairs (defined as hairs less than 2cm in length) and the diameter of hairs (the diameter of 20 new hairs was randomly measured and the average value was taken).

[0047] (3) Scalp condition evaluation: The degree of scalp itching and oiliness was evaluated using the visual analog scale (VAS, 0-10 points, the higher the score, the more severe the symptoms). Scores were recorded at baseline, week 4, week 8, and week 12. At the same time, changes in scalp pH were detected.

[0048] (4) Safety evaluation: During the experiment, the subjects’ scalp was observed and recorded daily for adverse reactions such as erythema, papules, stinging, and itching. A safety assessment was conducted once a week, and the incidence of adverse reactions was calculated.

[0049] Experimental results: (1) The comparison of the reduction rate of hair loss in each group is shown in Table 1: Table 1 Comparison of hair loss reduction rates among groups

[0050] Note: 'a' indicates a comparison with the control group. P <0.05, the difference is statistically significant.

[0051] As shown in Table 1, the amount of hair loss in experimental groups 1-3 gradually decreased with the duration of use. At week 12, the average reduction rates of 24-hour hair loss were 68%, 75%, and 72%, respectively, and the average reduction rates of hair loss during the combing test were 70%, 76%, and 73%, respectively. In contrast, the reduction rate of 24-hour hair loss in the control group at week 12 was only 35%, and the reduction rate of hair loss during the combing test was 38%. The hair loss reduction effect in the experimental group was significantly better than that in the control group. P <0.05).

[0052] (2) The comparison of changes in the new hair growth indicators of each group is shown in Table 2: Table 2 Comparison of changes in new hair growth indicators among groups (Week 12)

[0053] Note: 'a' indicates a comparison with the control group. P <0.05, the difference is statistically significant.

[0054] As shown in Table 2, at week 12, the density of newly grown hair in experimental groups 1-3 increased by 35%, 42%, and 38% respectively compared to baseline, and the diameter of newly grown hair increased by 18%, 22%, and 20% respectively compared to baseline; while the density of newly grown hair in the control group increased by only 12%, and the diameter increased by 8%. The growth effect of newly grown hair in the experimental group was significantly better than that in the control group. P <0.05).

[0055] (3) The comparison of scalp condition improvement in each group is shown in Table 3: Table 3 Comparison of scalp condition improvement in each group (Week 12)

[0056] Note: 'a' indicates a comparison with the control group. P <0.05, the difference is statistically significant.

[0057] As shown in Table 3, the VAS scores for scalp itching and oiliness in the experimental group 1-3 gradually decreased with the duration of use. By week 12, the average reduction in itching scores was 65%, 70%, and 68%, and the average reduction in oiliness scores was 62%, 68%, and 65%, respectively. The scalp pH value remained within the healthy range of 5.5-6.5. In contrast, the control group only saw a reduction in itching and oiliness scores of 25% and 22%, respectively, and the scalp pH value fluctuated significantly.

[0058] (4) During the experiment, no subjects in experimental groups 1-3 experienced significant adverse reactions, with an adverse reaction rate of 0%; three subjects in the control group experienced mild scalp tingling, with an adverse reaction rate of 15%.

[0059] Therefore, the hair loss prevention and hair growth composition of the present invention can significantly reduce hair loss and promote the growth of new hair, while effectively improving discomfort such as scalp itching and oiliness, regulating the health of the scalp, and has high safety with no obvious adverse reactions. Its overall effect is better than conventional hair loss prevention products on the market and has significant clinical application value.

[0060] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A non- shedding hair growth composition characterized in that, By weight percentage, it includes the following components: 5-30% active ingredients, 5-20% moisturizer, 1-5% emulsifier, 0.1-1% preservative, and the balance being deionized water; By weight percentage, the active ingredients include 10-20% Platycladus orientalis leaf extract, 8-15% ginger extract, 10-20% Eclipta prostrata extract, 8-15% Ligustrum lucidum extract, 5-10% Morus alba root bark extract, 5-10% Clematis chinensis extract, 5-10% ginseng extract, and 5-10% panthenol.

2. A hair loss prevention composition according to claim 1, wherein: The active ingredient accounts for 15-25% by weight.

3. The hair loss prevention composition according to claim 1, wherein: The moisturizer is selected from one or more combinations of glycerin, propylene glycol, and hyaluronic acid.

4. The hair loss prevention composition according to claim 1, wherein: The emulsifier is selected from one or more combinations of cetearyl alcohol polyether-25, stearyl alcohol polyether-2, and Tween 80.

5. The hair loss prevention and hair growth composition according to claim 1, characterized in that: The preservative is selected from one or more combinations of phenoxyethanol, methylparaben, and chlorphenesin.

6. A method for preparing the anti-hair loss and hair growth composition according to any one of claims 1-5, characterized in that, Includes the following steps: S1. Raw material pretreatment: After crushing the arborvitae leaves, ginger, eclipta prostrata, privet fruit, mulberry bark, clematis root, and ginseng, the effective components were extracted by ethanol reflux extraction. The extract was purified by macroporous resin, filtered, and concentrated to obtain the corresponding extracts for later use. S2. Aqueous phase preparation: Add deionized water to the reactor, heat to 70-80℃, add humectant and preservative in sequence, stir until completely dissolved, and keep warm for 30 minutes. S3. Oil phase preparation: In a separate container, add the emulsifier, heat to 75-85℃, and stir until melted and uniform; S4. Emulsification and mixing: Slowly add the oil phase to the water phase while stirring. The stirring speed is 300-500 r / min and the stirring time is 20-30 min. Then cool down to 45-55℃. S5. Add active ingredients: Add the pretreated raw materials from S1 and panthenol to the above mixture and stir until homogeneous; S6. Finished product: Continue cooling to room temperature, filter, and after passing inspection, the hair loss prevention and hair growth composition is obtained.

7. The preparation method according to claim 6, characterized in that, The conditions for ethanol reflux extraction in S1 are: ethanol concentration of 60-80%, solid-liquid ratio of 1:10-1:20, extraction temperature of 70-85℃, extraction time of 2-4 hours, and extraction times of 2-3 times.

8. The preparation method according to claim 6, characterized in that: After emulsification and mixing in S4, homogenization is performed at a pressure of 20-30 MPa for 5-10 minutes.

9. The preparation method according to claim 6, characterized in that: In S5, the stirring speed is 200-300 r / min and the stirring time is 15-20 min.

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