Application of organic acid metal compound as animal feed additive

Abstract

The invention belongs to the field of animal feed additives, and particularly relates to application of organic acid metal compounds and / or solvates as or in preparation of animal feed additives. The organic acid metal compound and / or the solvate thereof provided by the invention can effectively increase the weight of animals and improve the feed conversion rate, has a good effect of improving the production performance of the animals, and can improve the production efficiency of the animals by applying the organic acid metal compound and / or the solvate thereof to the animals. Basically no residue exists in tissues such as muscles and livers of edible animals.

Description

Technical Field

[0001] This invention relates to the field of animal feed additives, and more specifically to the use of a class of organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives. Background Technology

[0002] Organic aluminum compounds are diverse and widely used, with formic acid aluminum compounds and acetate aluminum compounds being the most common. Formic acid aluminum compounds are often used as catalysts in organic synthesis reactions, especially esterification reactions, where they can promote ester formation and increase reaction rates and yields, such as in the synthesis of amino acid esters. As wood preservatives, formic acid aluminum compounds help protect wood from fungi, insects, and other organisms. They penetrate the wood surface and bind with the fibers to form a protective film, extending the lifespan of the wood. Formic acid aluminum compounds can be used as components in certain dyes and pigments, and can also be added to pulp as paper reinforcing agents. Acetate aluminum compounds have antibacterial, anti-inflammatory, and antipruritic effects. As early as the early 20th century, acetic acid aluminum compounds were used in the pharmaceutical and dyeing fields as preservatives, astringents, and antipyretics. Acetate aluminum compounds can also be used as catalysts and color-fixing agents in leather dyeing and tanning processes.

[0003] In addition, organic Al compounds have been disclosed for use in the preparation of polyurethane foam, or as anti-caking agents, stabilizers, or viscosity control agents in foundations, sunscreens, and moisturizing creams; or as nucleating agents and surfactants in plastics processing; or as components of defoamers; or as components of conductor pastes in the preparation of chip resistor electrodes; or as components of lubricating grease compositions; or as catalyst compositions for polyesters. However, no reports have been found on the application of organic acid Al compounds in the feed industry and animal husbandry. Summary of the Invention

[0004] Based on this, the present invention provides the use of a class of organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives, and also provides compositions comprising the organic acid metal compounds and / or their solvates.

[0005] To achieve the above-mentioned objectives of this invention, this invention provides a molecular formula of Al n (R 1 ) n (R 2 ) n (R 3 ) n Use of organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives:

[0006] Where n is any natural number; R 1Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols;

[0007] Y is selected from H, straight chain, or branched C1-C. 19 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 19 Alkyl, C3-C7 cycloalkyl or 1-5 R 4 Substituted C3-C7 cycloalkyl, C3-C7 cyclohexaalkyl or 1-5 R 4 Substituted C3-C7 cyclohexaalkyl, C5-C 12 Aryl groups may be surrounded by 1-5 R groups. 5 Replacement C5-C 12 Aryl, C5-C 12 heteroaryl or surrounded by 1-5 R 5 Replacement C5-C 12 heteroaryl, -(CH=CH) m -(C5-C 12 (aryl) or 1-5 R 5 Replace C5-C 12 Aryl group -(CH=CH) m -(C5-C 12 Aryl), -(CH=CH) m -(C5-C 12 (Heteroaryl) or with 1-5 R 5 Replace C5-C 12 heteroaryl -(CH=CH) m -(C5-C 12 (Heteroary aryl);

[0008] m is any natural number;

[0009] R 4 It is -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I;

[0010] R 5 It is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I.

[0011] The present invention also provides a composition comprising Al n (R 1 ) n (R 2 ) n (R3 ) n The organic acid metal compound and / or its solvate; preferably, the organic acid metal compound and / or its solvate is the active component.

[0012] The present invention also provides a product containing the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n The use of a combination of organic acid metal compounds and / or their solvates as or in the preparation of an animal feed additive, preferably an animal growth promoter.

[0013] This invention provides a method for improving animal production performance, the method comprising administering an animal with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates or containing the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Compositions of organic acid metal compounds and / or their solvates.

[0014] This invention, through animal breeding experiments, confirms that the organic acid metal compound and / or its solvates provided by this invention can effectively increase animal weight gain and improve feed conversion rate, demonstrating a good effect on improving animal production performance. More importantly, the organic acid metal compound and / or its solvates provided by this invention leave virtually no residue in the muscle, liver, and other tissues of edible animals. The aluminum content is lower than the detection limit of aluminum detection instruments, lower than the aluminum content in commercially available meat products, or lower than the aluminum content in the meat products of edible animals in the blank control group that were not given the organic acid metal compound. This meets the requirements for aluminum residue in food as specified in the National Food Additives Standard GB 2760-2014 [Aluminum residue ≤ 100 mg / kg (equivalent to 100 ppm), (dry sample, calculated as Al)].

[0015] Any embodiment of any aspect of the present invention can be combined with other embodiments, provided that there is no contradiction between them. Furthermore, in any embodiment of any aspect of the present invention, any technical feature can be applied to the same technical feature in other embodiments, provided that there is no contradiction between them.

[0016] The foregoing description only outlines certain aspects of the invention, but is not limited to these aspects. The foregoing and other aspects will be described in more detail below.

[0017] Detailed description of the invention

[0018] The following detailed description is intended to enable those skilled in the art to implement different embodiments. The description of specific devices, techniques, or applications is merely illustrative. The invention is intended to encompass all alternatives, modifications, and equivalents, all of which are included within the scope of the invention as defined in the claims. Furthermore, certain technical features of the invention are clearly visible and are described separately in multiple independent embodiments, but may also be provided in combination or in any suitable sub-combination in a single embodiment.

[0019] The organic acid metal compound involved in this invention

[0020] This invention relates to a class of molecules with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates.

[0021] Where n is any natural number; R 1 Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols;

[0022] Y is selected from H, straight chain, or branched C1-C. 19 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 19 Alkyl, C3-C7 cycloalkyl or 1-5 R 4 Substituted C3-C7 cycloalkyl, C3-C7 cyclohexaalkyl or 1-5 R 4 Substituted C3-C7 cyclohexaalkyl, C5-C 12 Aryl groups may be surrounded by 1-5 R groups. 5 Replacement C5-C 12 Aryl, C5-C 12 heteroaryl or surrounded by 1-5 R 5 Replacement C5-C 12 heteroaryl, -(CH=CH) m -(C5-C 12 (aryl) or 1-5 R 5Replace C5-C 12 Aryl group -(CH=CH) m -(C5-C 12 Aryl), -(CH=CH) m -(C5-C 12 (Heteroaryl) or with 1-5 R 5 Replace C5-C 12 heteroaryl -(CH=CH) m -(C5-C 12 (Heteroary aryl);

[0023] m is any natural number;

[0024] R 4 It is -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I;

[0025] R 5 It is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I.

[0026] Generally, "substituted" means that one or more substituted hydrogen atoms in the given structure are replaced by a specific substituent. A substituted group can have one substituent at each substituted position of the group. When more than one position in the given structural formula can be replaced by one or more substituents of a specific group, the substituents can be substituted at each position in the same or different ways.

[0027] In this invention, "C" a -C b "Alkyl" refers to a straight-chain or branched saturated alkyl group containing a to b carbon atoms, such as methyl, ethyl, propyl, isopropyl, ..., while "C1-C5 alkyl" refers to a straight-chain or branched saturated alkyl group containing 1 to 5 carbon atoms.

[0028] In this invention, "CH=CH" represents an olefin fragment with the structure -HC=CH-, (CH=CH) m This represents a conjugated olefin fragment consisting of m -HC=CH- groups linked by single bonds.

[0029] GB987715A, GB190708576A, GB190708643A, and GB182446A disclose existing processes for preparing Al salts of organic acids. These processes and their variations can be used to prepare the aforementioned organic acid metal compounds, the R involved in their structures... 2 and R 3 When it is not OH, R 2 and R3 It can be with R 1 Same or different.

[0030] The organic acid metal compounds provided by this invention can be in the form of monomers or polymers.

[0031] The monomers involved in this invention refer to organic acid metal compounds with the molecular formula Al(R) 1 (R) 2 (R) 3 ).

[0032] The polymers involved in this invention refer to organic acid metal compounds with the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) n In this case, n is a natural number greater than 2.

[0033] In some preparation schemes, the reaction selectivity of the substrate with multiple active functional groups may be problematic during the reaction, leading to a change in the product obtained from the above-mentioned organic acid metal compound preparation schemes, where the molecular formula Al is different. n (R 1 ) n (OH) n (OH) n Al n (R 1 ) n (R 2 ) n (OH) n And Al n (R 1 ) n (R 2 ) n (R 3 ) n One or more components of the compound, R 1 Selected from YC(O)O or plant polyphenols, R 2 and R 3 Each and every one is independently selected from: -OH, YC(O)O- or plant polyphenols; preferably, R 1 R 2 and R 3 In this preparation method, YC(O)O- or plant polyphenols are represented.

[0034] The "plant polyphenols" involved in this invention refer to secondary metabolites with polyphenolic structures derived from natural plants, including but not limited to curcumin, grape polyphenols, ellagic acid, magnolol, red dogwood extract, tea polyphenols, hydrolyzed tannins, chestnut tannins, grapefruit tannins, and tannic acid.

[0035] In some specific preparation methods, the aforementioned product is preferably composed of Al n (R 1 ) n (OH) n (OH) n Al n (R 1 ) n (R 1 ) n (OH) n And Al n (R 1 ) n (R 1 ) n (R 1 ) n One or more components of the compound, R 1 R 2 and R 3 In this preparation method, YC(O)O- or plant polyphenols are represented.

[0036] In some preparation methods, the product obtained is R 1 Selected from plant polyphenols, R 2 and R 3 Organic acid metal compounds, selected independently from -OH or plant polyphenols.

[0037] In some specific preparation methods, the obtained product is R 1 Selected from tannic acid, R 2 and R 3 Organic acid metal compounds, selected independently from -OH or tannic acid.

[0038] The "tannic acid" involved in this invention refers to tannins obtained from gallnuts, also known as tannic acid, tannic acid, tannins, or tannins.

[0039] In some preparation methods, the product obtained is R 1 Selected from YC(O)O-, R 2 and R 3 Organic acid metal compounds independently selected from: -OH, YC(O)O-, where Y is selected from: straight-chain or branched C1-C 15 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 15 Alkyl, R 4It can be -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I.

[0040] In some implementations, the resulting product is R 1 Selected from YC(O)O-, R 2 and R 3 Organic acid metal compounds independently selected from: -OH, YC(O)O-, where Y is selected from: C4-C5 cyclohexaalkyl or 1-5 R 4 Substituted C4-C5 cycloheteroalkyl, R 4 It can be -OH, -NH2, -CN, -SH or -X1, where X1 is selected from F, Cl, Br or I.

[0041] In some implementations, the resulting product is R 1 Selected from YC(O)O-, R 2 and R 3 Organic acid metal compounds independently selected from: -OH, YC(O)O-, where Y is selected from: phenyl or surrounded by 1-5 R 5 Substituted phenyl, R 5 It is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I.

[0042] In some implementations, the resulting product is R 1 Selected from YC(O)O-, R 2 and R 3 Organic acid metal compounds independently selected from: -OH, YC(O)O-, where Y is selected from: C4-C5 heteroaryl or surrounded by 1-5 R groups. 5 Substituted C4-C5 heteroaryl groups, wherein the heteroaryl group is a heteroaryl group containing O, S, or N, R 5 It is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I.

[0043] In some embodiments, the Y in the organic acid metal compound and / or its solvates is 3-pyridyl.

[0044] In some embodiments, the R of organic acid metal compounds and / or their solvates 1 Selected from YC(O)O-, R 2 and R 3 The components are independently selected from -OH and YC(O)O-, where Y is selected from -(CH=CH). m-phenyl or phenyl substituted by 1-5 R 5 -(CH=CH) m -phenyl, m is any natural number, R 5 is -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or -C1-C5 alkyl substituted by X2, where X2 is selected from F, Cl, Br or I.

[0045] In some embodiments, R of the organic acid metal compound and / or its solvate 1 is selected from Y-C(O)O-, R 2 and R 3 are each independently selected from: -OH and Y-C(O)O-, Y is selected from -(CH=CH)-phenyl.

[0046] In some embodiments, the solvate of the organic acid metal compound in the organic acid metal compound and / or its solvate is selected from: one, more than one or a combination of hydrate, acetone complex, ethanol complex, methanol complex, dimethyl sulfoxide complex, ethyl acetate complex, acetic acid complex, and / or isopropanol complex of the organic acid metal compound.

[0047] In some embodiments, the organic acid metal compound and / or its solvate is selected from a single one or more organic acid metal compounds with the same or different molecular formulas, a single one or more solvates of organic acid metal compounds with the same or different molecular formulas, and a combination of one or more organic acid metal compounds with the same or different molecular formulas and one or more solvates of organic acid metal compounds with the same or different molecular formulas.

[0048] In some embodiments, the organic acid metal compound includes a monomer of the organic acid metal compound or a polymer of the organic acid metal compound.

[0049] In some of the preparation examples, the organic acid metal compound is one of the compounds with the following molecular formulas:

[0050] Al n (OH) 2n (CH3COO) n (abbreviation "Al acetate"), Al n (OH) 2n (CH3(CH2)2COO) n (abbreviation "Al butyrate"), Al n (OH) 2n (CH3(CH2)8COO) n (abbreviation "Al caprate"), Al n (OH) 2n (CH3(CH2) 12COO) n (abbreviation "14Al"), Al n (OH) 2n (CH3(CH2) 14 COO) n (abbreviation "Brown Al"), (abbreviation "Benzene Al"), (abbreviation "NAl"), (abbreviation "KAl"), (abbreviation "RAl").

[0051] In some of the preparation examples, the organic acid metal compound is one of the following combinations:

[0052] "Ethyl Al combination" is Al n (OH) 2n (CH3COO) n , Al n (OH) n (CH3COO) 2n and Al n (CH3COO) 3n or a combination of one or more of them;

[0053] "Butyl Al combination" is Al n (OH) 2n (CH3(CH2)2COO) n , Al n (OH) n (CH3(CH2)2COO) 2n , and Al n (CH3(CH2)2COO) 3n or a combination of one or more of them;

[0054] "Decyl Al combination" is Al n (OH) 2n (CH3(CH2)8COO) n , Al n (OH) n (CH3(CH2)8COO) 2n and Al n (CH3(CH2)8COO) 3n or a combination of one or more of them;

[0055] "14Al combination" is Al n (OH) 2n (CH3(CH2) 12 COO) n , Al n (OH) n(CH3(CH2) 12 COO) 2n And Al n (CH3(CH2) 12 COO) 3n One or more combinations thereof;

[0056] "Brown Al combination" is Al n (OH) 2n (CH3(CH2) 14 COO) n Al n (OH) n (CH3(CH2) 14 COO) 2n And Al n (CH3(CH2) 14 COO) 3n One or more combinations thereof; "Benzene-Al combination" is , and One or more combinations thereof; "NA1 combination" is , and One or more combinations thereof; "KAl combination" is , and One or more combinations thereof; "RAl group" is , and One or more combinations thereof.

[0057] The "organic acid metal compound" involved in this invention includes organic acid metal compound monomers or organic acid metal compound polymers; it also includes combinations of one or more organic acid metal compounds with the same or different molecular formulas.

[0058] In some embodiments, the preparation process of the organometallic acid compound also involves the separation, purification, or recrystallization of the reaction product. The reaction product can be obtained as a crude product from the reaction system via a solvent removal method. To obtain a solid substance with higher chemical purity and lower impurity content, the crude product is dissolved, crystallized, precipitated, recrystallized, and separated in an alcohol solvent, an alcohol-water mixed solvent, or other organic solvents suitable for recrystallization under appropriate temperature, light, and mechanical vibration conditions to obtain an organometallic acid compound with a specific physical form.

[0059] The organic acid-metal compound having a certain physical form is a solvate of the organic acid-metal compound. The solvate of the organic acid-metal compound may be selected from: hydrates, acetone compounds, ethanol compounds, methanol compounds, dimethyl sulfoxide compounds, ethyl acetate compounds, acetate compounds, and isopropanol compounds of the organic acid-metal compound.

[0060] The "solvate" involved in this invention refers to a eutectic association formed by the binding of stoichiometric or non-stoichiometric amounts of solvent molecules through non-covalent intermolecular forces during the contact between the compound and solvent molecules, caused by external and internal conditions. Solvents forming solvates include, but are not limited to, water, acetone, ethanol, methanol, dimethyl sulfoxide, ethyl acetate, acetic acid, and isopropanol. "Hydrate" refers to an association or crystal formed where the solvent molecules are water, that is, a compound in which stoichiometric or non-stoichiometric amounts of water are bound together through non-covalent intermolecular forces.

[0061] The "organic acid metal compound and / or its solvates" in this invention refer to a combination selected from: one or more individual organic acid metal compounds of the same or different molecular formulas, one or more individual organic acid metal compound solvates of the same or different molecular formulas, one or more organic acid metal compounds of the same or different molecular formulas, and one or more organic acid metal compound solvates of the same or different molecular formulas.

[0062] The bioavailability studies of the organic acid metal compounds provided by this invention include: experiments on the effects of the organic acid metal compounds and their solvates on the growth performance of piglets, broiler chickens, and laying hens, as well as studies on their application effects in duck feed. The results show that the organic acid metal compounds and their solvates, when applied to pig, chicken, and duck farming, effectively improve the growth rate of pigs, chickens, and ducks, reduce feed conversion ratio, improve growth efficiency, and promote growth.

[0063] This invention also investigated the residual Al element in the muscle or tissue of broiler chickens, ducks, pigs, and laying hens when the organic acid metal compound and its solvates were applied to their feed. The results showed that in a long-term feeding trial of 3-6 months, the residual Al element in the animals contained in the organic acid metal compound was lower than that in the blank control group or lower than the detection limit of the instrument. This fully demonstrates that the organic acid metal compound and its solvates of this invention can be applied to the feed of broiler chickens, ducks, pigs, and laying hens, and that there is no residual Al element in the muscle or tissue of the aforementioned animals.

[0064] The application of the organic acid metal compounds involved in this invention

[0065] Based on the results of bioavailability studies of organic acid metal compounds and their solvates and the results of studies on their residues in animals, this invention provides the application of the organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives.

[0066] The term "animal" in this invention refers to domesticated animals that cannot convert inorganic matter into organic matter, can only consume organic matter, and whose life activities include feeding, digestion, absorption, respiration, circulation, excretion, sensation, movement, and reproduction. "Domesticated animals" include poultry, livestock, aquatic animals, and other legally captured animals raised in captivity, including pets such as cats and dogs. The term "livestock" includes, for example, any of pigs, cattle, horses, goats, sheep, deer, and many useful rodents. The term "poultry" includes, for example, chickens, ducks, geese, quails, pigeons, etc. The term "aquatic animals" includes, for example, fish, shrimp, turtles, soft-shelled turtles, etc.

[0067] The organic acid metal compounds and / or their solvates provided by this invention are used as or used to prepare growth promoters for animals at various growth stages, wherein the animals may be selected from livestock, poultry, aquaculture animals or other animals, including pets, at various growth stages.

[0068] Furthermore, the livestock include, but are not limited to, pigs, cattle, sheep, deer, horses, rabbits, minks, or donkeys; the poultry include, but are not limited to, chickens, turkeys, ducks, geese, quails, or pigeons; the aquatic animals include, but are not limited to, fish, shrimp, turtles, crabs, soft-shelled turtles, bullfrogs, eels, or loaches; and the pets include, but are not limited to, various subspecies of dogs or cats.

[0069] In one embodiment, the organic acid metal compound and / or its solvates provided by the present invention are used as or used to prepare feed additives that improve the production performance of hogs, wherein the feed additives have a significant effect on improving the average daily weight gain and feed conversion ratio of hogs.

[0070] In another embodiment, the organic acid metal compound and / or its solvates provided by the present invention are used as or to prepare feed additives that improve the production performance of broilers or laying hens, said feed additives can significantly improve the production performance of broilers or laying hens.

[0071] In another embodiment, the organic acid metal compound and / or its solvates provided by the present invention are used as or to prepare feed additives that improve the production performance of meat ducks, said feed additives can significantly improve the production performance of meat ducks.

[0072] In another embodiment, the organic acid metal compound and / or its solvates provided by the present invention are used as or to prepare a feed additive that improves the production performance of fish, said feed additive significantly improving the production performance of fish.

[0073] The composition involved in this invention

[0074] The “composition” of the present invention refers to a group or collection of compounds comprising one or more compounds, and more specifically, to a group or collection of compounds comprising one or more compounds as an active ingredient or component.

[0075] The composition provided by the present invention comprises the aforementioned organic acid metal compound and / or its solvate, and further, the effective ingredient or component of the composition is the aforementioned organic acid metal compound and / or its solvate.

[0076] The organic acid metal compound and / or its solvates are composed of Al. n (R 1 ) n (OH) n (OH) n Al n (R 1 ) n (R 2 ) n (OH) n And Al n (R 1 ) n (R 2 ) n (R 3 ) n One or more components of the compound, R 1 Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each polyphenol is independently selected from: -OH, YC(O)O-, or plant polyphenols; preferably, it is composed of Al n (R 1 ) n (OH) n (OH) n Al n (R 1 ) n (R 1 ) n (OH) n And Al n (R 1 ) n (R 1 ) n (R 1 ) n One or more components of the compound, R 1 R 2 and R 3 It represents YC(O)O- or plant polyphenols.

[0077] Furthermore, the composition provided by the present invention comprising the aforementioned organic acid metal compound and / or its solvates also comprises one or a combination of feedable adjuvants, additional animal feed additives, and animal feed ingredients.

[0078] Furthermore, the organic acid metal compound and / or its solvate provided by the present invention are selected from one, more or a combination thereof, of the following: hydrates, acetone compounds, ethanol compounds, methanol compounds, dimethyl sulfoxide compounds, ethyl acetate compounds, acetate compounds, and / or isopropanol compounds.

[0079] Furthermore, the aforementioned organic acid metal compounds and / or their solvates are selected from one or more individual organic acid metal compounds of the same or different molecular formulas, one or more individual organic acid metal compound solvates of the same or different molecular formulas, one or more organic acid metal compounds of the same or different molecular formulas, and a combination of one or more organic acid metal compound solvates of the same or different molecular formulas.

[0080] Furthermore, the aforementioned organic acid metal compounds include organic acid metal compound monomers or organic acid metal compound polymers.

[0081] The term "comprising" as used in this invention is an open-ended expression, encompassing both the content explicitly referred to in this invention and excluding other aspects.

[0082] Furthermore, the feedable excipient is selected from one or more of the following: carrier, diluent, excipient, and solvent.

[0083] The "carrier" involved in this invention refers to a feedable substance capable of carrying active ingredients, improving their dispersibility, and possessing good chemical stability and adsorption properties, including organic and inorganic carriers. The organic carriers are selected from materials rich in crude fiber, including but not limited to corn flour, corn cob flour, wheat bran, rice husk flour, defatted rice bran, rice bran, corn stalk flour, and peanut shell flour. The inorganic carriers are selected from minerals, further selected from calcium salts and silicon oxides, used in the preparation of trace element premixes, including but not limited to calcium carbonate, silicates, vermiculite, zeolite, and sepiolite.

[0084] The "diluent" involved in this invention refers to a substance that uniformly distributes additive raw materials in a material, diluting high-concentration additive raw materials into low-concentration premixes or premixes. It can separate trace components from each other, reduce interactions between active ingredients, and increase the stability of active ingredients without affecting the physicochemical properties of the substances. This includes organic and inorganic diluents. Organic diluents include, but are not limited to, corn flour, degermed corn flour, dextrose (glucose), sucrose, whole wheat flour with bran, roasted soybean flour, wheat middlings, and corn gluten meal. Inorganic diluents include, but are not limited to, limestone, calcium dihydrogen phosphate, shell powder, kaolin (white clay), salt, and sodium sulfate.

[0085] The "excipients" involved in this invention refer to wetting agents that induce the inherent viscosity of a substance, adhesives that bind substances together, disintegrants that break down a whole sheet of a substance into many fine particles, retention aids that reduce interparticle friction, or anti-adhesion agents that prevent materials from sticking together, including but not limited to magnesium stearate, talc, vegetable oil, magnesium lauryl sulfate, starch, starch paste, water, inorganic salts, dextrin, powdered sugar, etc.

[0086] The "solvent" involved in this invention refers to the solvent required to dissolve or disperse solids, including but not limited to water, ethanol, glycerol, etc.

[0087] The "feed additives" involved in this invention refer to small or trace amounts of substances added during feed processing, production, and use, including nutritional feed additives and general feed additives, also known as non-nutritive feed additives.

[0088] The "animal feed additives" involved in this invention refer to one or more of the following: nutritional feed additives, general feed additives, or medicated feed additives.

[0089] The “nutritional feed additives” involved in this invention refer to small or trace amounts of substances added to compound feed to balance feed nutrients, improve feed utilization, and directly exert a nutritional effect on animals, including amino acids, amino acid salts and their analogues, vitamins and vitamin-like substances, mineral elements and their complexes (chelates), microbial enzyme preparations, or non-protein nitrogen.

[0090] The "general feed additives" involved in this invention, also known as "non-nutritive additives," refer to non-nutritive substances added to feed to improve feed utilization, ensure feed quality and grade, and benefit animal health or metabolism. These include growth promoters, deworming and health care agents, flavoring and palatability enhancers, feed conditioners, feed formulations, feed storage agents, and traditional Chinese medicine additives.

[0091] The term "feed" as used in this invention refers to industrially processed and manufactured products intended for animal consumption. Unless otherwise stated, the term "feed" or "animal feed" comprises animal feed ingredients and one or more animal feed additives. In some embodiments, the animal feed ingredients include grains and their processed products, oilseeds and their processed products, legume seeds and their processed products, tubers and roots and their processed products, other seeds and fruits and their processed products, forage and roughage and their processed products, other plants and algae and their processed products, dairy products and their by-products, terrestrial animal products and their by-products, fish and other aquatic organisms and their by-products, minerals, microbial fermentation products and by-products, and other feed ingredients, etc.

[0092] Use of the composition

[0093] This invention relates to the use of the above-mentioned compositions comprising the aforementioned organic acid metal compounds and / or their solvates; further, this invention relates to the use of the above-mentioned compositions comprising organic acid metal compounds and / or their solvates as active ingredients or components.

[0094] In some embodiments, the composition or feed composition comprising an organic acid metal compound and / or its solvates is used as or in the preparation of an animal feed additive.

[0095] The use of compositions or feed compositions comprising the aforementioned organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives, wherein the animal feed additives are selected from livestock feed additives, poultry feed additives, aquaculture animal feed additives, or pet feed additives. Specifically, the animal feed additives are animal growth promoters.

[0096] Specifically, the use of compositions or feed compositions comprising the organic acid metal compounds and / or their solvates as or in the preparation of livestock feed additives, wherein the livestock include, but are not limited to, pigs, cattle, sheep, horses, rabbits, mink, etc. at various growth stages.

[0097] Specifically, the use of compositions or feed compositions comprising the organic acid metal compounds and / or their solvates as or in the preparation of poultry feed additives, wherein the poultry includes, but is not limited to, chickens, ducks, geese, pigeons, etc. at various growth stages.

[0098] Specifically, the use of compositions or feed compositions comprising the organic acid metal compounds and / or their solvates as feed additives for aquaculture animals, wherein the aquaculture animals include, but are not limited to, fish, shrimp, crabs, turtles, eels, etc. at various growth stages.

[0099] Specifically, the use of compositions or feed compositions comprising the organic acid metal compound and / or its solvates as pet food additives or in the preparation of pet food, wherein the pets include, but are not limited to, artificially bred dogs or cats.

[0100] Specifically, the use of the composition or feed composition comprising an organic acid metal compound and / or its solvates as an animal feed additive or in the preparation of such an animal feed additive is selected from premixes, compound premixes, aqueous solutions or granules.

[0101] In some embodiments, compositions or feed compositions comprising the organic acid metal compound and / or its solvates are used as or in the preparation of animal feed.

[0102] Specifically, the animal feed, as or prepared using a composition or feed composition comprising the organic acid metal compound and / or its solvates, is selected from livestock feed, poultry feed, aquaculture animal feed, or pet feed.

[0103] Specifically, the livestock feed is a composition or feed composition containing an organic acid metal compound and / or its solvates, including but not limited to pigs, cattle, sheep, horses, rabbits, mink, etc. at various growth stages.

[0104] Specifically, poultry feed is a composition or feed composition containing an organic acid metal compound and / or its solvates, wherein the poultry includes, but is not limited to, chickens, ducks, geese, pigeons, etc. at various growth stages.

[0105] Specifically, a composition or feed composition comprising an organic acid metal compound and / or its solvates is used as or prepared as feed for aquaculture animals, including but not limited to fish, shrimp, crab, turtle, eel, etc. at various growth stages.

[0106] Specifically, pet food is prepared as or made from a composition or feeding composition comprising an organic acid metal compound and / or its solvates, wherein the pets include, but are not limited to, artificially bred dogs or cats.

[0107] In some embodiments, compositions or feed compositions comprising organic acid metal compounds and / or their solvates are used as or in the preparation of feeds, said feeds being selected from single feeds, concentrated feeds, compound feeds, compound premixes, or concentrate supplements.

[0108] Specifically, the compound feed is a complete compound feed.

[0109] Methods to improve the production performance of farmed animals

[0110] The method for improving animal production performance provided by this invention includes administering an animal with the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates, or those containing an active ingredient of the molecular formula Al, which is administered to animals. n (R 1 ) n (R 2 ) n (R 3 ) n Compositions of organic acid metal compounds and / or their solvates.

[0111] In some embodiments, the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates, or compounds containing an effective component with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A composition of an organic acid metal compound and / or its solvates, administered to animals in combination with feed; the application of the organic acid metal compound and / or its solvates, or the composition, can significantly improve the production performance of the animals.

[0112] In some embodiments, the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates are mixed with animal feed and then consumed by the animals.

[0113] In some embodiments, the composition of the organic acid metal compound and / or its solvates is selected from premixes, composite premixes, granules, or aqueous solutions, and contains an effective component with the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) nA combination of organic acid metal compounds and / or their solvates, which are mixed with animal feed and then fed to animals.

[0114] Specifically, the animals are selected from livestock, poultry, aquaculture animals, or pets.

[0115] Specifically, the livestock include, but are not limited to, pigs, cattle, sheep, horses, rabbits, minks, etc. at various growth stages; the poultry include, but are not limited to, chickens, ducks, geese, pigeons, etc. at various growth stages; the aquatic animals include, but are not limited to, fish, shrimp, crabs, turtles, eels, etc. at various growth stages; and the pets include, but are not limited to, artificially raised dogs or cats.

[0116] In one embodiment, the molecular formula Al is used. n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates, or containing an effective component with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Combinations of organic acid metal compounds and / or their solvates, administered to weaned piglets in combination with feed; this method of administration can significantly improve the average daily weight gain and feed conversion ratio of weaned piglets.

[0117] In one embodiment, the molecular formula Al is used. n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates, or containing an effective component with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A combination of organic acid metal compounds and / or their solvates, administered to broilers in combination with feed; this method of administration can significantly reduce the feed conversion ratio of broilers and improve feed conversion rate.

[0118] In one embodiment, the molecular formula Al is used. n (R 1 ) n (R 2 )n (R 3 ) n Organic acid metal compounds and / or their solvates, or containing an effective component with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A combination of organic acid metal compounds and / or their solvates, administered to fish in combination with feed.

[0119] In one embodiment, the molecular formula Al is used. n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates, or containing an effective component with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n A combination of an organic acid metal compound or its solvate, administered to puppies in combination with their feed.

[0120] In other embodiments, the aforementioned effective component is of the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) n Combinations of organic acid metal compounds and / or their solvates are administered to animals; this method of administration can significantly improve the production performance of animals.

[0121] Optionally, the composition is selected from feed additive premixes, feed additive compound premixes, granules or liquids, and / or given to animals in combination with feed.

[0122] In one embodiment, the composition is a feed additive premix.

[0123] In one embodiment, the composition is a feed additive compound premix.

[0124] Optionally, the composition is a concentrated feed, compound feed, compound premix or concentrate supplement, or can be directly fed to animals as animal feed.

[0125] In one embodiment, the composition is a complete compound feed. Detailed Implementation

[0126] To make the objectives, technical solutions, and advantages of this invention clearer, the compounds, compositions, and applications of this invention are further described in detail below through examples. It should be understood that the specific examples described herein are for illustrative purposes only and are not intended to limit the scope of this invention.

[0127] Example 1: Effects of organic acid metal compounds on the growth performance of piglets

[0128] Two hundred Duroc × Landrace × Large White three-way crossbred lean-type piglets of similar weight at 45 days of age were randomly divided into 10 treatment groups, with two replicates per group, half male and half female, and 10 piglets per replicate. The specific groupings are shown in Table 1. The pigpens and equipment were disinfected before the experiment. During the experiment, the piglets were housed separately in the same pen under the same feeding and management conditions. The piglets had free access to feed and water during the experiment. Group A served as the blank control group, receiving only nursery feed; experimental groups B and H were given nursery feed containing different organic acid metal compounds. No additional antioxidants or growth promoters were added to any of the experimental groups throughout the feeding process. The experiment lasted 28 days, and the growth performance of the pigs was statistically analyzed. The average daily feed intake (ADFI, g / d*head), average daily weight gain (ADG, g / d*head), and feed conversion ratio (FCR) of the experimental pigs are expressed as "average values," as shown in Table 1.

[0129] Fertilizer ratio (FCR) = Average daily feed intake / Average daily weight gain;

[0130] Weight gain rate = (Experimental group ADG - Control group ADG) / Control group ADG * 100%;

[0131] Increase in feed intake rate = (ADFI in experimental group - ADFI in control group) / ADFI in control group * 100%;

[0132] Feed conversion ratio decrease rate = (FCR of control group - FCR of experimental group) / FCR of control group * 100%.

[0133] Table 1. Effects of organometallic acid compounds on the growth performance of piglets.

[0134] The results show that the organic acid metal compounds involved in the experiment significantly improved or increased the feed conversion ratio of the experimental pigs, as reflected in a 9.82%-11.90% reduction in the feed conversion ratio compared to the blank control group. Furthermore, in terms of weight gain, the experimental group showed an average daily weight gain increase of 12.25%-25.64% compared to the blank control group. Regarding feed intake, butane Al, decane Al, brown Al, benzene Al, and NAl all increased the feed intake of the experimental pigs to varying degrees.

[0135] Example 2: Effects of organic acid metal compounds on broiler growth performance

[0136] The experiment employed a single-factor randomized design, selecting 600 one-day-old, yellow-feathered broiler chickens with similar average weights (50g) and randomly dividing them into 10 treatment groups, with 3 replicates per group and 20 chickens per replicate (half male and half female). The groupings are shown in Table 2. The chicken houses and equipment were disinfected before the experiment. During the experimental period, the chickens were cage-raised under the same conditions in the same chicken house. The basal diet consisted mainly of corn-soybean meal, with no additional antioxidants or growth promoters added throughout the feeding process. Experiment A served as the control group, receiving only the basal diet. Experiments B through H added 250 ppm of an organic acid metal compound to the basal diet, as shown in Table 2. The experiment lasted 20 days, with free access to water and feed, and the chickens were fed twice daily. For each replicate, chickens were weighed at 21 days of age (feed withheld for 12 hours, water supply continued), and feed consumption was recorded. The average daily feed intake (ADFI, g / d*bird), average daily weight gain (ADG, g / d*bird), and feed conversion ratio (FCR) of each group of chickens were calculated using the following formulas:

[0137] Fertilizer ratio (FCR) = Average daily feed intake / Average daily weight gain;

[0138] Weight gain rate = (Experimental group ADG - Control group ADG) / Control group ADG * 100%;

[0139] Increase in feed intake rate = (ADFI in experimental group - ADFI in control group) / ADFI in control group * 100%;

[0140] Feed conversion ratio decrease rate = (FCR of control group - FCR of experimental group) / FCR of control group * 100%.

[0141] The experimental results are shown in Table 2.

[0142] Table 2. Application effects of organic acid metal compounds in broiler feed

[0143] The results showed that the organic acid metal compounds involved in the experiment had a significant effect on improving or increasing the feed intake, average daily weight gain and feed conversion ratio of the experimental chickens. Compared with the blank control group, the feed intake of the experimental chickens increased by 9.40%-29.87%, the average daily weight gain increased by 25.89%-50.89%, and the feed conversion ratio decreased by 11.95%-14.13%.

[0144] Example 3: Research on the application of organic acid metal compounds in duck feed

[0145] A single-factor experimental design was used. Forty-eighty Cherry Valley ducks, aged one day with similar weight and in good health, were randomly divided into eight treatments, with three replicates per treatment and twenty ducks per replicate. The control group received a blank diet supplemented with a corn-soybean meal basal diet. The other treatment groups received supplemental diets, with different organic acid-metallic compounds added to the basal diet. The experiment lasted 42 days. Specific animal groupings are shown in Table 3. During the experiment, ducks had free access to feed and water. Immunization was performed according to the standard immunization schedule. Feed intake, feed consumption, and mortality were observed and recorded daily for each group. Ducks were weighed on an empty stomach at the beginning and end of the experiment. After the experiment, the average daily weight gain, average daily feed intake, and feed conversion ratio were statistically analyzed for each treatment group on a replicate basis. The results are shown in Table 3.

[0146] Table 3. Application effects of organic acid metal compounds in duck feed

[0147] The results showed that the organic acid metal compounds involved in the experiment had a significant effect on improving or increasing the feed intake, average daily weight gain and feed conversion ratio of the experimental ducks. Compared with the blank control group, the feed intake of the experimental ducks increased by 7.26%-23.46%, the average daily weight gain increased by 19.06%-38.90%, and the feed conversion ratio decreased by 10.42%-11.99%.

[0148] Example 4: Study on the effects of Al benzoate compound on the laying performance of laying hens

[0149] A Hy-Line Grey laying hen flock (277 days old, 38,395 birds) with stable production performance was observed for two weeks after continuous monitoring of normal production data. Then, benzoic acid Al compound (referred to as "benzoic acid Al") (500 g / ton) was added to the complete feed for 33 days, followed by another 33 days using the complete feed without benzoic acid Al. Daily data on egg production, mortality, feed consumption, temperature, and humidity were recorded, and data were summarized approximately every two weeks as one experimental phase. The entire experiment consisted of five phases: pre-control (14 days), benzoic acid Al salt I (14 days), benzoic acid Al salt II (19 days), post-control I (14 days), and post-control II (19 days). In addition, a sample of eggs was randomly collected weekly to test eggshell thickness and strength.

[0150] Detailed production performance data are as follows: (1) Increased egg production rate: The egg production rate of the flock increased from 91.71% in the previous control stage to 93.57% (benzene Al I) and 93% (benzene Al II). After discontinuation, the egg production rate decreased to 91.72% (post-control I) and 91.96% (post-control II), which is comparable to the previous control stage; (2) Improved feed conversion ratio: The feed conversion ratio in the previous control stage was 2.063:1. The feed conversion ratio in the experimental stage was significantly improved, decreasing to 2.0:1 (benzene Al I) and 1.970:1 (benzene Al II). After discontinuation of benzene Al, the feed conversion ratios were 1.976 (post-control I) and 1.996 (post-control II), respectively; (3) Decreased daily feed intake: After using benzene Al, the average daily feed intake decreased from 116.79 g to 115.27 g (benzoate Al salt I) and 112.69 g (benzene Al II); (4) No significant change in eggshell thickness.

[0151] Comprehensive statistical analysis of experimental data clearly shows that the use of benzene Al improved gut health, increased egg production, decreased feed conversion ratio, reduced daily feed intake, and showed a downward trend in average egg weight. Furthermore, the production performance of flocks discontinued from benzene Al continued to improve, demonstrating a sustained aftereffect.

[0152] Example 5: Residual analysis of different organic acid metal compounds in different animals

[0153] I. Experimental animals: White-feathered broiler chickens (1 day old), yellow-feathered broiler chickens (1 day old), broiler ducks (1 day old), pigs (15 kg), laying hens (eggs)

[0154] II. Experimental Methods:

[0155] 1. Add high doses of organic acid metal compounds to the feed, and test the Al content in muscle or tissue samples taken at different ages during a long-term feeding trial of 3-6 months, as shown in Table 4-10.

[0156] 2. The experimental design included a blank control group without the addition of organic acid metal compounds.

[0157] 3. The Al content in the feed was tested after adding different organic acid metal compounds.

[0158] III. Test Results

[0159] (I) Results of the White-feathered Broiler Chicken Trial

[0160] Table 4. Test results of broiler chickens (40 days old)

[0161] (II) Experimental Results of Yellow-feathered Broiler Chickens

[0162] Table 5. Test results of yellow-feathered broiler chickens at 40 days of age

[0163] Table 6. Test results of yellow-feathered broiler chickens at 80 days of age

[0164] Table 7. Test results of yellow-feathered broiler chickens at 120 days of age

[0165] (III) Results of the experiment with laying hens:

[0166] The Al content in eggs was detected in eggs both before and 1-4 weeks after the use of organic acid metal compounds.

[0167] Table 8. Detection results of Al content in eggs

[0168] (iv) Results of the duck experiment

[0169] Table 9. Test results of duck samples (40 days old)

[0170] (v) Results of the experiment with pigs

[0171] Table 10 Summary of Test Results for Pig Experimental Samples

[0172] This invention, through animal breeding experiments, confirms that the organic acid metal compound and / or its solvates provided by this invention can effectively increase animal weight gain and improve feed conversion rate, demonstrating a good effect on improving animal production performance. More importantly, the organic acid metal compound and / or its solvates provided by this invention leave virtually no residue in the muscle, liver, and other tissues of edible animals. The aluminum content is lower than the detection limit of aluminum detection instruments, lower than the aluminum content in commercially available meat products, or lower than the aluminum content in the meat products of edible animals in the blank control group that were not given the organic acid metal compound. This meets the requirements for aluminum residue in food as specified in the National Food Additives Standard GB 2760-2014 [Aluminum residue ≤ 100 mg / kg (equivalent to 100 ppm), (dry sample, calculated as Al)].

[0173] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. The molecular formula is Al n (R 1 ) n (R 2 ) n (R 3 ) n Use of organic acid metal compounds and / or their solvates as or in the preparation of animal feed additives: in, n is any natural number; R 1 Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or plant polyphenols; Y is selected from H, straight chain, or branched C1-C. 19 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 19 Alkyl, C3-C7 cycloalkyl or 1-5 R 4 Substituted C3-C7 cycloalkyl, C3-C7 cyclohexaalkyl or 1-5 R 4 Substituted C3-C7 cyclohexaalkyl, C5-C 12 Aryl groups may be surrounded by 1-5 R groups. 5 Replacement C5-C 12 Aryl, C5-C 12 heteroaryl or surrounded by 1-5 R 5 Replacement C5-C 12 heteroaryl, -(CH=CH) m -(C5-C 12 (aryl) or 1-5 R 5 Replace C5-C 12 Aryl group -(CH=CH) m -(C5-C 12 Aryl), -(CH=CH) m -(C5-C 12 (Heteroaryl) or with 1-5 R 5 Replace C5-C 12 heteroaryl -(CH=CH) m -(C5-C 12 (Heteroary aryl); m is any natural number; R 4 The components are selected from -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I; R 5 It is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I.

2. The use according to claim 1, characterized in that, The organic acid metal compound and / or its solvates have the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) n , where R 1 Selected from plant polyphenols, R 2 and R 3 Each is independently selected from -OH or plant polyphenols, preferably R 1 It is tannic acid, R 2 and R 3 Each is independently selected from OH or tannic acid.

3. The use according to claim 1, characterized in that, The organic acid metal compound and / or its solvates have the molecular formula Al. n (R 1 ) n (R 2 ) n (R 3 ) n , where R 1 Selected from YC(O)O-, R 2 and R 3 Each is independently selected from -OH or YC(O)O-, where Y is selected from straight-chain or branched C1-C. 15 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 15 Alkyl, R 4 The components are selected from -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I; Or, where R 1 Selected from YC(O)O-, R 2 and R 3 Each is independently selected from -OH or YC(O)O-, where Y is selected from C4-C5 cyclohexane or 1-5 R groups. 4 Substituted C4-C5 cycloheteroalkyl, R 4 The components are selected from -OH, -NH2, -CN, -SH, or -X1, where X1 is selected from F, Cl, Br, or I; Or, where R 1 Selected from YC(O)O-, R 2 and R 3 Each is independently selected from -OH or YC(O)O-, where Y is selected from phenyl or surrounded by 1-5 R groups. 5 Substituted phenyl, R 5 Selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I; Or, where R 1 Selected from YC(O)O-, R 2 and R 3 Each is independently selected from -OH or YC(O)O-, where Y is selected from C4-C5 heteroaryl groups or surrounded by 1-5 R groups. 5 Substituted C4-C5 heteroaryl groups, wherein the heteroaryl group is a heteroaryl group containing O, S, or N, R 5 The derivative is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I; preferably, Y is 3-pyridyl. Or, where R 1 Selected from YC(O)O-, R 2 and R 3 Each is independently selected from -OH or YC(O)O-, and Y is selected from -(CH=CH). m -Phenyl or with 1-5 R 5 Substituted phenyl group -(CH=CH) m -phenyl, m is any natural number, R 5 The Y is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br or I; preferably, Y is selected from -(CH=CH)-phenyl.

4. The use according to claim 1, characterized in that, The organic acid metal compound and / or its solvates are used as animal growth promoters for use as or in the preparation of animal feed additives.

5. The use according to claim 1, characterized in that, The organometallic acid compound and / or its solvates are selected from one, several, or combinations thereof of hydrates, acetone compounds, ethanol compounds, methanol compounds, dimethyl sulfoxide compounds, ethyl acetate compounds, acetic acid compounds, and / or isopropanol compounds of organometallic acid compounds; preferably, the organometallic acid compound and / or its solvates are selected from one or more organometallic acid compounds of the same or different molecular formulas, one or more organometallic acid compounds of the same or different molecular formulas, one or more organometallic acid compounds of the same or different molecular formulas, and a combination of one or more organometallic acid compounds of the same or different molecular formulas; more preferably, the organometallic acid compound comprises an organometallic acid compound monomer or an organometallic acid compound polymer.

6. A composition, characterized in that, The composition contains Al. n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates: Where n is any natural number from 1 to 10; R 1 Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each of the following is independently selected from -OH, YC(O)O- and plant polyphenols; preferably, R 1 Selected from YC(O)O- or tannic acid, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or tannic acid; Y is selected from H, straight chain, or branched C1-C. 19 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 19 Alkyl, C3-C7 cycloalkyl or 1-5 R 4 Substituted C3-C7 cycloalkyl, C3-C7 cyclohexaalkyl or 1-5 R 4 Substituted C3-C7 cyclohexaalkyl, C5-C 12 Aryl groups may be surrounded by 1-5 R groups. 5 Replacement C5-C 12 Aryl, C5-C 12 heteroaryl or surrounded by 1-5 R 5 Replacement C5-C 12 heteroaryl, -(CH=CH) m -(C5-C 12 (aryl) or 1-5 R 5 Replace C5-C 12 Aryl group -(CH=CH) m -(C5-C 12 Aryl), -(CH=CH) m -(C5-C 12 (Heteroaryl) or with 1-5 R 5 Replace C5-C 12 heteroaryl -(CH=CH) m -(C5-C 12 (Heteroary aryl); m is any natural number; R 4 Selected from -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I; R 5 The derivative is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br, or I.

7. The composition according to claim 6, characterized in that, The composition contains Al. n (R 1 ) n (OH) n (OH) n , or Al n (R 1 ) n (R 2 ) n (OH) n , or Al n (R 1 ) n (R 2 ) n (R 3 ) n One, more, or a combination thereof of an organometallic acid compound and / or its solvates; Where, n, R 1 R 2 R 3 Y, m, R 4 R 5 X1 and X2 are as described in claim 6.

8. The composition according to claim 6, characterized in that, The composition comprises Al n (R 1 ) n (OH) n (OH) n Al n (R 1 ) n (R 1 ) n (OH) n And Al n (R 1 ) n (R 1 ) n (R 1 ) n One, more, or a combination thereof of an organometallic acid compound and / or its solvates; Where, n, R 1 R 2 R 3 Y, m, R 4 R 5 X1 and X2 are as described in claim 6.

9. The composition according to any one of claims 6-8, characterized in that, The organometallic acid compound and / or its solvates are selected from one, several, or combinations thereof of hydrates, acetone compounds, ethanol compounds, methanol compounds, dimethyl sulfoxide compounds, ethyl acetate compounds, acetic acid compounds, and / or isopropanol compounds of organometallic acid compounds; preferably, the organometallic acid compound and / or its solvates are selected from one or more organometallic acid compounds of the same or different molecular formulas, one or more organometallic acid compounds of the same or different molecular formulas, one or more organometallic acid compounds of the same or different molecular formulas, and a combination of one or more organometallic acid compounds of the same or different molecular formulas; more preferably, the organometallic acid compound comprises an organometallic acid compound monomer or an organometallic acid compound polymer.

10. The composition according to any one of claims 6-9, characterized in that, The composition further comprises animal feed ingredients, additional animal feed additives and / or feedable adjuvants, wherein the additional animal feed additives are selected from at least one of nutritional feed additives, non-nutritive feed additives or medicated feed additives.

11. Use of the composition according to any one of claims 6-10 as or in the preparation of an animal feed additive, preferably, the animal feed additive is an animal growth promoter.

12. A method for improving animal production performance, the method comprising administering to the animal an animal a substance with the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Organic acid metal compounds and / or their solvates or containing the molecular formula Al n (R 1 ) n (R 2 ) n (R 3 ) n Compositions of organic acid metal compounds and / or their solvates: in, n is any natural number from 1 to 10; R 1 Selected from YC(O)O- or plant polyphenols, R 2 and R 3 Each of the following is independently selected from -OH, YC(O)O- and plant polyphenols; preferably, R 1 Selected from YC(O)O- or tannic acid, R 2 and R 3 Each is independently selected from -OH, YC(O)O-, or tannic acid; Y is selected from H, straight chain, or branched C1-C. 19 Alkyl groups or those with 1-5 R groups 4 Replacement of straight or branched C1-C 19 Alkyl, C3-C7 cycloalkyl or 1-5 R 4 Substituted C3-C7 cycloalkyl, C3-C7 cyclohexaalkyl or 1-5 R 4 Substituted C3-C7 cyclohexaalkyl, C5-C 12 Aryl groups may be surrounded by 1-5 R groups. 5 Replacement C5-C 12 Aryl, C5-C 12 heteroaryl or surrounded by 1-5 R 5 Replacement C5-C 12 heteroaryl, -(CH=CH) m -(C5-C 12 (aryl) or 1-5 R 5 Replace C5-C 12 Aryl group -(CH=CH) m -(C5-C 12 Aryl), -(CH=CH) m -(C5-C 12 (Heteroaryl) or with 1-5 R 5 Replace C5-C 12 heteroaryl -(CH=CH) m -(C5-C 12 (Heteroary aryl); m is any natural number; R 4 Selected from -OH, -NH2, -CN, -SH or -X1, wherein X1 is selected from F, Cl, Br or I; R 5 The derivative is selected from -OH, -NH2, -NO2, -CN, -SH, -X2, -C1-C5 alkoxy, -C1-C5 alkyl, or X2-substituted -C1-C5 alkyl, wherein X2 is selected from F, Cl, Br, or I.

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