Sample analysis apparatus and control method thereof

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses a control method of sample analysis equipment and the sample analysis equipment, and the control method of the sample analysis equipment comprises the following steps: controlling a sample container transmission device to transmit a first sample container loaded with a first volume of reference liquid to a liquid level detection position; controlling the liquid level detection device to detect the liquid level of the first sample container to obtain a first liquid level height value; controlling a sample container conveying device to convey a second sample container loaded with a second volume of reference liquid to a liquid level detection position; controlling the liquid level detection device to detect the liquid level of the second sample container to obtain a second liquid level height value; according to the first volume, the first liquid level height value, the second volume and the second liquid level height value, a first conversion model used for representing the relation between the volume and the liquid level height of the liquid in the first type of sample container is obtained. Through establishment of the first conversion model, accurate detection of the total liquid amount and the hematocrit of the sample can be facilitated.

Description

Sample analysis equipment and its control method Technical Field

[0001] This invention relates to the field of in vitro diagnostic equipment, and more particularly to a control method for a sample analysis device and a sample analysis device employing the control method. Background Technology

[0002] This related technology provides a sample analysis device for coagulation testing. For coagulation testing, detecting the total fluid volume and HCT (hematocrit) of the sample is a crucial part of sample quality verification. In this related technology, the total fluid volume of the sample is obtained by using a sample needle on the sample analysis device to detect the fluid level, obtaining the total fluid level height h. The total fluid volume V is then calculated as V = h * π * d² / 4 by manually inputting the inner diameter d of the sample container. The HCT of the sample is obtained through two main methods: 1) Method 1: The sample is photographed using a visual camera to identify the heights of the plasma and erythrocyte fluid levels, and the height of the erythrocyte fluid level is compared with the height of the plasma fluid level (i.e., the total fluid level height of the sample) to obtain the HCT. 2) Method 2: The HCT test results are obtained by using a LIS (Laboratory Information Management System) to acquire the test data of samples from the same patient measured by a hematology analyzer.

[0003] The aforementioned methods for obtaining the total liquid volume and HCT of a sample have the following shortcomings in practical applications: 1) In the method using a sample needle to measure the total liquid volume, although the total liquid volume can be measured, the HCT cannot be measured. Furthermore, because the sample container is not a standard cylinder, its inner diameter varies at different locations along the height, so the input inner diameter of the sample container may be inaccurate, leading to an inaccurate calculated total liquid volume. Additionally, if two or more types of sample containers are used, their inner diameters may differ, resulting in an inaccurate total liquid volume measurement. 2) In the method using height comparison to detect HCT, because the inner diameter of the sample container varies at different locations along the height, the HCT obtained by directly comparing heights may be inaccurate. 3) In the scheme of obtaining HCT through the test data of the hematology analyzer, the HCT test results are greatly affected by the LIS system because the system outside the sample analysis equipment is required. For example, the same patient may not have a test result from the hematology analyzer, or the hematology analyzer test result may be later than the coagulation test result. These situations will result in the inability to obtain the HCT test results of the sample in a timely manner when the sample analysis equipment is used for quality verification. Summary of the Invention

[0004] The first objective of this invention is to provide a control method for a sample analysis device, which aims to solve the technical problem of low accuracy in detecting total sample volume and hematocrit in related technologies.

[0005] To achieve the above objectives, the present invention provides a control method for a sample analysis device, comprising the following steps in a conversion model calibration process:

[0006] The control sample container transport device transports the first sample container, which contains a first volume of reference liquid, to the liquid surface detection position;

[0007] The control liquid level detection device performs liquid level detection on the first sample container located at the liquid level detection position to obtain the first liquid level height value of the reference liquid in the first sample container;

[0008] The sample container transport device is controlled to transport the second sample container, which contains the second volume of the reference liquid, to the liquid level detection position;

[0009] The liquid level detection device is controlled to perform liquid level detection on the second sample container located at the liquid level detection position to obtain the second liquid level height value of the reference liquid in the second sample container;

[0010] Based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, a first conversion model is obtained to characterize the relationship between the volume of liquid and the liquid level height in the container of the first type of sample.

[0011] Wherein, the first volume is greater than or less than the second volume;

[0012] The first sample container and the second sample container are two sample containers of the first type; or, the first sample container and the second sample container are the same sample container of the first type.

[0013] In one implementation, the control liquid level detection device performs liquid level detection on the first sample container located at the liquid level detection position to obtain a first liquid level height value corresponding to the first volume, including: controlling the camera device to take a picture of the first sample container located at the liquid level detection position to obtain a first target image, and obtaining the first liquid level height value based on the first target image;

[0014] The control liquid level detection device performs liquid level detection on the second sample container located at the liquid level detection position to obtain a second liquid level height value corresponding to the second volume, including: controlling the camera device to take a picture of the second sample container located at the liquid level detection position to obtain a second target image, and obtaining the second liquid level height value based on the second target image;

[0015] Preferably, the first target image includes at least an image showing the entire height of one side of the first sample container in a two-dimensional and / or three-dimensional form, and the second target image includes at least an image showing the entire height of one side of the second sample container in a two-dimensional and / or three-dimensional form.

[0016] Alternatively, the first target image may include at least an image showing all the reference liquid in the first sample container in a two-dimensional and / or three-dimensional form, and the second target image may include at least an image showing all the reference liquid in the second sample container in a two-dimensional and / or three-dimensional form.

[0017] Alternatively, the first target image may include at least images showing the bottom, middle, and top of the first sample container in a two-dimensional and / or three-dimensional form, and the second target image may include at least images showing the bottom, middle, and top of the second sample container in a two-dimensional and / or three-dimensional form.

[0018] In one implementation, the control camera device takes a picture of the first sample container located at the liquid level detection position to obtain a first target image, and obtains the first liquid level height value based on the first target image, including: controlling the camera device to take at least two pictures of the first sample container located at the liquid level detection position to obtain at least two first target images, and obtaining the first liquid level height value based on the at least two first target images;

[0019] The control camera device takes a picture of the second sample container located at the liquid level detection position to obtain a second target image, and obtains the second liquid level height value based on the second target image, including: controlling the camera device to take at least two pictures of the second sample container located at the liquid level detection position to obtain at least two second target images, and obtaining the second liquid level height value based on the at least two second target images.

[0020] As one implementation, obtaining the first liquid level height value based on the at least two first target images includes: obtaining at least two first initial height values ​​that correspond one-to-one with the at least two first target images, and averaging the at least two first initial height values ​​to obtain the first liquid level height value;

[0021] The step of obtaining the second liquid level height value based on the at least two second target images includes: obtaining at least two second initial height values ​​that correspond one-to-one with the at least two second target images, and averaging the at least two second initial height values ​​to obtain the second liquid level height value;

[0022] Alternatively, obtaining the first liquid level height value based on the at least two first target images includes: obtaining three first initial height values ​​corresponding one-to-one with the three first target images, and taking one of the three first initial height values ​​other than the maximum and minimum values ​​as the first liquid level height value;

[0023] The step of obtaining the second liquid level height value based on the at least two second target images includes: obtaining three second initial height values ​​corresponding one-to-one with the three second target images based on the three second target images, and taking one of the three second initial height values ​​other than the maximum and minimum values ​​as the second liquid level height value;

[0024] Alternatively, obtaining the first liquid level height value based on the at least two first target images includes: obtaining at least four first initial height values ​​corresponding one-to-one with the at least four first target images based on at least four first target images; and averaging the two first initial height values ​​other than the maximum and minimum values ​​among the at least four first initial height values ​​to obtain the first liquid level height value.

[0025] The step of obtaining the second liquid level height value based on the at least two second target images includes: obtaining at least four second initial height values ​​corresponding one-to-one with the at least four second target images based on the at least four second target images; and averaging the two second initial height values ​​other than the maximum and minimum values ​​among the at least four second initial height values ​​to obtain the second liquid level height value.

[0026] As one implementation, before obtaining the first conversion model characterizing the relationship between the volume and liquid level of the liquid in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes:

[0027] Based on the maximum and minimum values ​​among all the first initial height values ​​obtained from the at least two first target images, a first range is obtained, and the first range is divided by the first liquid level height value to obtain a first ratio.

[0028] The second range is obtained by taking the maximum and minimum values ​​of all the second initial height values ​​obtained from the at least two second target images, and the second range is divided by the second liquid level height value to obtain the second ratio.

[0029] If both the first ratio and the second ratio are less than or equal to the first threshold, the first conversion model of the first conversion model calibration process is determined to be successfully calibrated. Based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, a first conversion model is obtained to characterize the relationship between the volume of the liquid in the first type of sample container and the liquid level height.

[0030] If either the first ratio or the second ratio is greater than the first threshold, then the first conversion of the first conversion model calibration process is determined.

[0031] As one implementation, before obtaining the first conversion model characterizing the relationship between the volume and liquid level of the liquid in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes:

[0032] The maximum and minimum values ​​of all the first initial height values ​​obtained from the at least two first target images are compared with the first liquid level height value one by one;

[0033] The maximum and minimum values ​​of all the second initial height values ​​obtained from the at least two second target images are compared with the second liquid level height value one by one;

[0034] If the difference between the maximum value of all first initial height values ​​and the first liquid level value, the difference between the first liquid level value and the minimum value of all first initial height values, the difference between the maximum value of all second initial height values ​​and the second liquid level value, and the difference between the second liquid level value and the minimum value of all second initial height values ​​are all less than or equal to the second threshold, then the first conversion model of the first conversion model calibration process is determined to be successfully calibrated. Based on the first volume, the first liquid level value, the second volume, and the second liquid level value, a first conversion model is obtained to characterize the relationship between the volume of liquid and the liquid level in the first type of sample container.

[0035] If at least one of the following is greater than the second threshold: the difference between the maximum value of all first initial height values ​​and the first liquid level value, the difference between the first liquid level value and the minimum value of all first initial height values, the difference between the maximum value of all second initial height values ​​and the second liquid level value, and the difference between the second liquid level value and the minimum value of all second initial height values, then the first conversion model calibration of the first conversion model calibration process is determined to have failed.

[0036] As one implementation, before obtaining the first conversion model characterizing the relationship between the volume of liquid in the first type of sample container and the liquid level based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the calibration process of the first conversion model further includes: controlling the sample container transport device to transport the third sample container containing the reference liquid of the third volume to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the third sample container located at the liquid level detection position to obtain the third liquid level height value corresponding to the third volume;

[0037] The step of obtaining a first conversion model to characterize the relationship between the volume of liquid and the liquid level in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value includes: obtaining the first conversion model based on the first volume, the first liquid level value, the second volume, the second liquid level value, the third volume, and the third liquid level value;

[0038] Wherein, the third volume is greater than or less than the first volume, and the third volume is greater than or less than the second volume;

[0039] The third sample container, together with the first sample container and the second sample container, constitutes three sample containers of the first type; or, the third sample container and at least one of the first sample container and the second sample container constitute the same sample container of the first type.

[0040] In one embodiment, the control liquid level detection device performs liquid level detection on the first sample container located at the liquid level detection position to obtain a first liquid level height value corresponding to the first volume, including: controlling a liquid level detection device integrated on a pipette to perform liquid level detection on the first sample container located at the liquid level detection position to obtain the first liquid level height value;

[0041] The control liquid level detection device performs liquid level detection on the second sample container located at the liquid level detection position to obtain a second liquid level height value corresponding to the second volume, including: controlling the liquid level detection device integrated on the pipette to perform liquid level detection on the second sample container located at the liquid level detection position to obtain the second liquid level height value.

[0042] As one implementation, before the control sample container transfer device transfers the first sample container containing the first volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the first volume based on information input by the operator through the display screen;

[0043] Before the control sample container transfer device transfers the second sample container containing the second volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the second volume based on information input by the operator through a display screen.

[0044] As one implementation, before the controlled sample container transport device transports the first sample container containing a first volume of reference liquid to the liquid level detection position, the control method further includes: controlling the display screen to display at least one of the following information:

[0045] Information used to indicate and prompt the operator to place the first sample container and the second sample container into the target location of the sample analysis device;

[0046] This is used to prompt the operator to input information about the first volume and the second volume on the display screen.

[0047] As one implementation, the control method further includes: controlling the execution of the first conversion model calibration process when any one of the following first preset conditions is met:

[0048] The operator obtains information on executing the first conversion model calibration process based on the instructions input by the operator through the human-computer interaction device;

[0049] Obtain information to characterize the change or addition of sample container types;

[0050] Information on the position change of the liquid level detection position and / or the liquid level detection device is obtained;

[0051] Obtain information indicating that the first conversion model calibration process failed in the first conversion model calibration procedure;

[0052] Reaching the preset time point of the preset cycle;

[0053] Since the last execution of the first conversion model calibration process, the liquid level detection device has accumulated a preset operating time;

[0054] Since the last execution of the first conversion model calibration process, the liquid level detection device has accumulated a preset number of liquid level detections;

[0055] The human-computer interaction device includes at least one of a display screen, a voice interaction component, a button, a knob, and a push button.

[0056] As one implementation, the control method further includes: controlling the display screen to display the conversion model calibration function option on the function interface; and executing the conversion model calibration process steps when the conversion model calibration function option is triggered.

[0057] In one implementation, the first volume is half or twice the second volume;

[0058] And / or, the reference solution is one of mixed plasma, quality control material, calibrator, purified water, deionized water, and diluent.

[0059] In one implementation, the control method further includes the following detection process steps:

[0060] The sample container transfer device is controlled to transfer the fourth sample container, which contains the first sample to be tested, to the liquid level detection position;

[0061] The liquid level detection device is controlled to perform liquid level detection on the fourth sample container located at the liquid level detection position, so as to obtain the fourth liquid level height value of the first sample to be tested in the fourth sample container;

[0062] Based on the fourth liquid level height value and the first conversion model, the fourth volume of the first sample to be tested in the fourth sample container is obtained;

[0063] Wherein, the fourth liquid level height value is the total liquid level height value of the first sample to be tested in the fourth sample container;

[0064] The fourth volume is the total volume of the first sample to be tested within the fourth sample container;

[0065] The fourth sample container and the first sample container are two sample containers of the first type.

[0066] As one implementation, controlling the sample container transport device to transport the fourth sample container loaded with the first sample to be tested to the liquid level detection position includes: controlling the sample container transport device to transport the fourth sample container loaded with the first sample to be tested, and the first sample to be tested having been centrifuged into upper liquid, middle liquid and lower liquid, to the liquid level detection position, wherein the lower liquid contains red blood cells;

[0067] The detection process also includes the following steps:

[0068] The liquid level is detected by the liquid level detection device at the liquid level detection position of the fourth sample container to obtain the fifth liquid level height value of the lower liquid in the fourth sample container.

[0069] Based on the fifth liquid level height value and the first conversion model, the fifth volume of the lower liquid in the fourth sample container is obtained;

[0070] The hematocrit of the first test sample is obtained based on the fourth volume and the fifth volume.

[0071] As one implementation, the control method further includes: controlling the display screen to display the total volume and / or hematocrit of the first sample to be tested in the fourth sample container;

[0072] And / or, the control liquid level detection device performs liquid level detection on the fourth sample container located at the liquid level detection position to obtain the fourth liquid level height value and the fifth liquid level height value, including: controlling the camera device to take a picture of the fourth sample container located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image; the control method further includes: controlling the display screen to display the third target image; wherein, the third target image at least includes an image showing the entire height of one side of the fourth sample container in a two-dimensional and / or three-dimensional form, or at least includes an image showing all the first test samples in the fourth sample container in a two-dimensional and / or three-dimensional form, or at least includes an image showing the bottom, middle part, and top of the fourth sample container in a two-dimensional and / or three-dimensional form.

[0073] In one implementation, the control method further includes the following steps in a conversion model calibration process:

[0074] The control sample container transport device transports the fifth sample container, which contains the sixth volume of reference liquid, to the liquid level detection position;

[0075] The control liquid level detection device performs liquid level detection on the fifth sample container located at the liquid level detection position to obtain the sixth liquid level height value of the reference liquid in the fifth sample container;

[0076] The sample container transport device is controlled to transport the sixth sample container, which contains the seventh volume of the reference liquid, to the liquid level detection position, wherein the sixth volume is greater than or less than the seventh volume;

[0077] The liquid level detection device is controlled to perform liquid level detection on the sixth sample container located at the liquid level detection position to obtain the seventh liquid level height value of the reference liquid in the sixth sample container;

[0078] Based on the sixth volume, the sixth liquid level height value, the seventh volume, and the seventh liquid level height value, a second conversion model is obtained to characterize the relationship between the volume of liquid and the liquid level height in the container of the second type of sample.

[0079] The control method further includes the following steps in the detection process:

[0080] The sample container transport device controls the seventh sample container, which contains the second sample to be tested and which has been centrifuged into upper liquid, middle liquid and lower liquid, to the liquid surface detection position. The lower liquid contains red blood cells.

[0081] The liquid level detection device is controlled to perform liquid level detection on the seventh sample container located at the liquid level detection position, so as to obtain the eighth liquid level height value of the second sample to be tested in the seventh sample container and the ninth liquid level height value of the lower liquid in the seventh sample container.

[0082] Based on the eighth liquid level height value and the second conversion model, the eighth volume of the second sample to be tested in the seventh sample container is obtained;

[0083] Based on the ninth liquid level height value and the second conversion model, the ninth volume of the lower layer liquid in the seventh sample container is obtained;

[0084] The hematocrit of the second sample to be tested is obtained based on the eighth volume and the ninth volume.

[0085] Wherein, the eighth liquid level height value is the total liquid level height value of the second sample to be tested in the seventh sample container;

[0086] The eighth volume is the total volume of the second sample to be tested within the seventh sample container;

[0087] The fifth sample container, the sixth sample container, and the seventh sample container are three second-type sample containers, or the fifth sample container and the sixth sample container are the same second-type sample container, and the seventh sample container is another second-type sample container;

[0088] The first type of sample container and the second type of sample container differ in at least one of the following: shape, size.

[0089] As one implementation, the control of the sample container transport device to transport a first sample container containing a first volume of reference liquid to the liquid level detection position includes: controlling the sample container transport device to transport the first sample container from the first storage area of ​​the sample management device to the liquid level detection position.

[0090] Controlling the sample container transfer device to transfer a second sample container containing a second volume of the reference liquid to the liquid level detection position includes: controlling the sample container transfer device to transfer the second sample container from the first storage area to the liquid level detection position;

[0091] Controlling the sample container transfer device to transfer the fourth sample container containing the first sample to be tested to the liquid level detection position includes: controlling the sample container transfer device to transfer the fourth sample container from the first storage area to the liquid level detection position;

[0092] The control of the sample container transport device to transport the fifth sample container containing the sixth volume of reference liquid to the liquid level detection position includes: the control of the sample container transport device to transport the fifth sample container from the second storage area of ​​the sample management device to the liquid level detection position;

[0093] Controlling the sample container transfer device to transfer the sixth sample container containing the seventh volume of the reference liquid to the liquid level detection position includes: controlling the sample container transfer device to transfer the sixth sample container from the second storage area to the liquid level detection position;

[0094] Controlling the sample container transfer device to transfer the seventh sample container containing the second sample to be tested to the liquid level detection position includes: controlling the sample container transfer device to transfer the seventh sample container from the second storage area to the liquid level detection position;

[0095] The first storage area and the second storage area are located in two different areas of the sample management device. The first storage area is used to place the first type of sample container to realize the feeding of the first type of sample container, and the second storage area is used to place the second type of sample container to realize the feeding of the second type of sample container.

[0096] As one implementation, before obtaining the first conversion model characterizing the relationship between the volume of liquid and the liquid level in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes: obtaining information that the first sample container belongs to the first type of sample container based on feedback information from the identification device's identification of the first sample container; and obtaining information that the second sample container belongs to the first type of sample container based on feedback information from the identification device's identification of the second sample container.

[0097] Before obtaining the fourth volume of the first sample to be tested in the fourth sample container based on the fourth liquid level height value and the first conversion model, the control method further includes: obtaining information that the fourth sample container belongs to the first type of sample container based on the feedback information of the identification device's identification of the fourth sample container;

[0098] Before obtaining the second conversion model characterizing the relationship between the volume and liquid level of the liquid in the second type of sample container based on the sixth volume, the sixth liquid level value, the seventh volume, and the seventh liquid level value, the control method further includes: obtaining information that the fifth sample container belongs to the second type of sample container based on feedback information from the identification device's identification of the fifth sample container; and obtaining information that the sixth sample container belongs to the second type of sample container based on feedback information from the identification device's identification of the sixth sample container.

[0099] Before obtaining the eighth volume of the second sample to be tested in the seventh sample container based on the eighth liquid level height value and the second conversion model, the control method further includes: obtaining information that the seventh sample container belongs to the second type of sample container based on the feedback information of the identification device's identification of the seventh sample container.

[0100] A second objective of this invention is to provide a control method for a sample analysis device, the control method comprising the following steps in a detection process:

[0101] The control sample container transport device transports the sample container containing the first sample to be tested to the liquid level detection position;

[0102] The control liquid level detection device performs liquid level detection on the sample container located at the liquid level detection position to obtain the fourth liquid level height value of the first sample to be tested in the sample container;

[0103] Based on the fourth liquid level height value and the first conversion model, the fourth volume of the first sample to be tested in the sample container is obtained;

[0104] The first conversion model is used to characterize the relationship between the volume of liquid in the sample container and the liquid level.

[0105] The fourth liquid level height value is the total liquid level height value of the first sample to be tested in the sample container;

[0106] The fourth volume is the total volume of the first sample to be tested within the sample container.

[0107] As one implementation, controlling the sample container transport device to transport the sample container containing the first sample to be tested to the liquid level detection position includes: controlling the sample container transport device to transport the sample container containing the first sample to be tested, after the first sample to be tested has been centrifuged and separated into an upper liquid layer, a middle liquid layer, and a lower liquid layer, to the liquid level detection position, wherein the lower liquid layer contains red blood cells;

[0108] The detection process also includes the following steps:

[0109] The liquid level of the sample container located at the liquid level detection position is detected by the liquid level detection device to obtain the fifth liquid level height value of the lower liquid in the sample container.

[0110] Based on the fifth liquid level height value and the first conversion model, the fifth volume of the lower liquid in the sample container is obtained;

[0111] The hematocrit of the first test sample is obtained based on the fourth volume and the fifth volume.

[0112] In one implementation, the controlled liquid level detection device performs liquid level detection on the sample container located at the liquid level detection position to obtain a fourth liquid level height value of the first sample to be tested in the sample container and a fifth liquid level height value of the lower liquid in the sample container, including: controlling a camera device to take a picture of the sample container located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image.

[0113] A third objective of this invention is to provide a sample analysis device, which includes:

[0114] A sample measuring device, the sample measuring device being used to: draw at least a portion of the sample to be tested from a sample container containing the sample to be tested and dispense it into a reaction container, and to measure the test solution in the reaction container which is at least composed of the sample to be tested and a reagent;

[0115] A sample container transport device, wherein the sample container transport device is used to transport the sample container;

[0116] A liquid level detection device, wherein the liquid level detection device is used to detect the liquid level of the sample container that has been transferred to the liquid level detection position by the sample container transfer device;

[0117] A display screen, which is at least used to display a functional interface;

[0118] A control device is configured to: control the display to show the conversion model calibration function option on the function interface; and when the conversion model calibration function option is triggered, execute the steps of the conversion model calibration process to obtain a conversion model for characterizing the relationship between the volume of liquid and the liquid level in the sample container.

[0119] In one implementation, the control device is further configured to perform the following detection process steps:

[0120] The sample container transfer device is controlled to transfer the sample container containing the sample to be tested to the liquid level detection position;

[0121] The liquid level detection device is controlled to perform liquid level detection on the sample container located at the liquid level detection position to obtain the fourth liquid level height value of the sample to be tested in the sample container;

[0122] Based on the fourth liquid level height value and the first conversion model, the fourth volume of the sample to be tested in the sample container is obtained;

[0123] Wherein, the fourth liquid level height value is the total liquid level height value of the sample to be tested in the sample container;

[0124] The fourth volume is the total volume of the sample to be tested within the sample container.

[0125] As one implementation, controlling the sample container transport device to transport the sample container containing the sample to be tested to the liquid level detection position includes: controlling the sample container transport device to transport the sample container containing the sample to be tested, and the sample to be tested having been centrifuged into upper liquid, middle liquid and lower liquid, to the liquid level detection position, wherein the lower liquid contains red blood cells;

[0126] The control device is also configured to perform the following steps of the detection process:

[0127] The liquid level of the sample container located at the liquid level detection position is detected by the liquid level detection device to obtain the fifth liquid level height value of the lower liquid in the sample container.

[0128] Based on the fifth liquid level height value and the first conversion model, the fifth volume of the lower liquid in the sample container is obtained;

[0129] The hematocrit of the sample to be tested is obtained based on the fourth volume and the fifth volume.

[0130] The control method for the sample analysis device provided by this invention uses a conversion model calibration process to detect the liquid level height of similar sample containers with different volumes, thereby establishing a conversion model to characterize the relationship between the volume of liquid and the liquid level height in such sample containers. This conversion model can then be used to accurately convert from liquid level height to volume. Thus, in the detection process of a specific sample, as long as the total liquid level height and the red blood cell layer liquid level height are detected, the conversion model can be used to accurately calculate the total liquid volume and red blood cell volume of the sample. Attached Figure Description

[0131] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0132] Figure 1 is a schematic diagram of the conversion model calibration process provided in an embodiment of the present invention;

[0133] Figure 2 is a schematic diagram of the distribution of a sample analysis device provided in an embodiment of the present invention;

[0134] Figure 3 is another schematic diagram of the distribution of the sample analysis device provided in an embodiment of the present invention;

[0135] Figure 4 is a schematic diagram of the sample determination device provided in an embodiment of the present invention;

[0136] Figure 5 is a schematic diagram of the camera device provided in an embodiment of the present invention indirectly capturing an image of a sample container through a reflector;

[0137] Figure 6 is a schematic diagram of the camera device provided in an embodiment of the present invention directly capturing images of a sample container;

[0138] Figure 7 is a schematic diagram showing the target image provided in an embodiment of the present invention.

[0139] Explanation of reference numerals: 10, Sample analysis equipment; 100, Sample management device; 200, Sample measurement device; 210, Sample aspiration channel; 220, Sample dispensing mechanism; 230, Measurement mechanism; 240, Incubation mechanism; 250, Reagent dispensing mechanism; 251, Mixed reagent dispensing assembly; 252, Trigger reagent dispensing assembly; 260, Reagent tray; 270, Reaction vessel supply mechanism; 280, Reaction vessel transfer mechanism; 300, Sample container transfer device; 3 10. Conveying track; 320. First sample container scheduling mechanism; 330. Sample container transfer device; 400. Camera device; 500. Control device; 600. Reflector; 800. Lighting component; 900. Centrifuge device; 101. Display screen; 1011. First target image; 1012. Second target image; 20. Sample container; 30. Sample to be tested; 31. Upper liquid layer; 32. Middle liquid layer; 321. Interface liquid surface; 33. Lower liquid layer. Detailed Implementation

[0140] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0141] This application provides a sample analysis device and its control method, applicable to analytical systems where the test object includes at least a sample collected from a human or animal, and the volume of liquid in the sample container and hematocrit need to be detected. The determination of the test sample by this sample analysis device includes, but is not limited to, coagulation tests.

[0142] As shown in Figures 1 to 7, a first aspect of the present invention provides a control method for a sample analysis device 10, comprising the steps of a conversion model calibration process as follows: controlling a sample container transfer device 300 to transfer a first sample container 20 containing a first volume of reference liquid to a liquid level detection position; controlling a liquid level detection device to perform liquid level detection on the first sample container 20 located at the liquid level detection position to obtain a first liquid level height value of the reference liquid in the first sample container 20; controlling the sample container transfer device 300 to transfer a second sample container 20 containing a second volume of reference liquid to the liquid level detection position; controlling... The liquid level detection device detects the liquid level in the second sample container 20 located at the liquid level detection position, obtaining a second liquid level height value of the reference liquid within the second sample container 20. Based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, a first conversion model is obtained to characterize the relationship between the volume and liquid level height of the liquid within the first type of sample container 20. The first volume is greater than or less than the second volume; the first sample container 20 and the second sample container 20 are two separate first type of sample containers 20; or, the first sample container 20 and the second sample container 20 are the same first type of sample container 20. The reference liquid is the liquid medium used to perform the conversion model calibration process. In this embodiment, at least two sample containers 20 of the same type, or the same sample container 20, are used to sequentially transport the same reference liquid containing different known volumes to the liquid level detection position. The liquid level detection device then sequentially detects the liquid level of the sample containers 20 located at the liquid level detection position and containing different volumes of reference liquid, thereby obtaining the liquid level height values ​​corresponding to the different known volumes. Based on at least two sets of known volumes and the detected liquid level heights, a first conversion model is established to characterize the relationship between the volume of liquid in the sample container 20 and the liquid level height. Thus, in the specific sample detection process, as long as the total liquid level height and the red blood cell layer liquid level height are detected, this conversion model can be used to accurately calculate the total liquid volume and red blood cell volume of the sample.

[0143] In one implementation, the reference solution is a mixed plasma. Specifically, the mixed plasma can be a liquid obtained by mixing the remaining plasma from different test samples 30. In practical applications, the amount of sample collected during testing may be more than the actual required amount, but the remaining amount from a single sample may not meet the reference solution requirements in the conversion model calibration process. Therefore, mixing the remaining plasma from different test samples 30 can make full use of resources, avoid waste, and reduce the cost of the reference solution. Of course, the method of setting the reference solution is not limited to this in practical applications. For example, as an alternative implementation, the reference solution can also be one of the following: quality control material, calibrator, purified water, deionized water, or diluent.

[0144] In one implementation, the first volume is half or twice the size of the second volume, which facilitates the quantitative determination of the first and second volumes. Of course, in specific applications, the arrangement of the first and second volumes is not limited to this.

[0145] As one implementation, before the control sample container transfer device 300 transfers the first sample container 20 containing the first volume of reference liquid to the liquid level detection position, the first sample container 20 can be prepared first, and then the first volume of reference liquid can be added to the first sample container 20 by manual operation or by a pipetting component. In specific applications, the first volume of reference liquid can be added to the first sample container 20 when the first sample container 20 is outside the sample analysis device 10, and after the operation of adding the first volume of reference liquid to the first sample container 20 is completed, the first sample container 20 containing the first volume can be placed in the sample analysis device 10; or, the first volume of reference liquid can be added to the first sample container 20 when the first sample container 20 is placed inside the sample analysis device 10.

[0146] As one implementation, before the control sample container transfer device 300 transfers the second sample container 20 containing the second volume of reference liquid to the liquid level detection position, the second sample container 20 can be prepared first, and then the second volume of reference liquid can be added to the second sample container 20 by manual operation or by a pipetting component. The specific method of adding the second volume of reference liquid to the second sample container 20 can be referred to the method of adding the first volume of reference liquid to the first sample container 20 described above, and will not be described in detail here.

[0147] In one implementation, the above-described liquid level detection device detects the liquid level in a first sample container 20 located at a liquid level detection position to obtain a first liquid level height value corresponding to a first volume. This includes controlling the camera device 400 to capture an image of the first sample container 20 at the liquid level detection position to obtain a first target image 1011, and obtaining the first liquid level height value based on the first target image 1011. Similarly, the above-described liquid level detection device detects the liquid level in a second sample container 20 located at a liquid level detection position to obtain a second liquid level height value corresponding to a second volume. This includes controlling the camera device 400 to capture an image of the second sample container 20 at the liquid level detection position to obtain a second target image 1012, and obtaining the second liquid level height value based on the second target image 1012. In this embodiment, the sample analysis device 10 includes a camera device 400. The liquid level height value within the sample container 20 is obtained by capturing images with the camera device 400. This liquid level detection method is simple and easy to implement.

[0148] Of course, in specific applications, the first liquid level height value and the second liquid level height value can also be detected by other methods. For example, as an alternative implementation, liquid level detection can be performed using a pipette. Specifically, in this alternative implementation, the above-mentioned control of the liquid level detection device to detect the liquid level of the first sample container 20 located at the liquid level detection position and obtain the first liquid level height value corresponding to the first volume includes: controlling the liquid level detection device integrated on the pipette to detect the liquid level of the first sample container 20 located at the liquid level detection position and obtain the first liquid level height value; the above-mentioned control of the liquid level detection device to detect the liquid level of the second sample container 20 located at the liquid level detection position and obtain the second liquid level height value corresponding to the second volume includes: controlling the liquid level detection device integrated on the pipette to detect the liquid level of the second sample container 20 located at the liquid level detection position and obtain the second liquid level height value. The liquid level detection device can be a capacitive sensor or a pressure sensor, etc.

[0149] In one implementation, the first target image 1011 includes at least an image showing the entire height of one side of the first sample container 20 in a two-dimensional and / or three-dimensional form, and the second target image 1012 includes at least an image showing the entire height of one side of the second sample container 20 in a two-dimensional and / or three-dimensional form; or, the first target image 1011 includes at least an image showing all the reference liquid inside the first sample container 20 in a two-dimensional and / or three-dimensional form, and the second target image 1012 includes at least an image showing all the reference liquid inside the second sample container 20 in a two-dimensional and / or three-dimensional form; or The first target image 1011 includes at least an image showing the surface of the reference liquid in the first sample container 20 in a two-dimensional and / or three-dimensional form, and the second target image 1012 includes at least an image showing the surface of the reference liquid in the second sample container 20 in a two-dimensional and / or three-dimensional form; or, the first target image 1011 includes at least an image showing the bottom, middle part, and top of the first sample container 20 in a two-dimensional and / or three-dimensional form, and the second target image 1012 includes at least an image showing the bottom, middle part, and top of the second sample container 20 in a two-dimensional and / or three-dimensional form. In this embodiment, the first target image 1011 is a full-view image of the first sample container 20 (it can be a full-view image of the first sample container 20 with or without a cap, a full-view image of the first sample container 20 with or without a stopper), which can at least show the entire height information of the first sample container 20; or the first target image 1011 is a full-view image of the reference liquid inside the first sample container 20, which can at least show the height information of the three liquid levels or the entire height information of the reference liquid inside the first sample container 20. For ease of description and understanding, the first target image 1011 can also be referred to as a full-view image of the second sample container 20 or a full-view image of the reference liquid inside the second sample container 20. The second target image 1012 is a full-view image of the second sample container 20 (it can be a full-view image of the second sample container 20 with or without a cap, a full-view image of the second sample container 20 with or without a stopper), which can at least show the entire height information of the second sample container 20; or the second target image 1012 is a full-view image of the reference liquid inside the second sample container 20, which can at least show the height information of the three liquid levels or the entire height information of the reference liquid inside the second sample container 20. For ease of description and understanding, the second target image 1012 can also be referred to as a full-view image of the second sample container 20 or a full-view image of the reference liquid inside the second sample container 20.

[0150] In one implementation, the aforementioned control camera device 400 captures an image of the first sample container 20 located at the liquid level detection position to obtain a first target image 1011. Based on the first target image 1011, a first liquid level height value is obtained. This includes: the control camera device 400 captures an image of the first sample container 20 located at the liquid level detection position at least twice to obtain at least two first target images 1011, and the first liquid level height value is obtained based on the at least two first target images 1011. In this implementation, the first liquid level height value is obtained by capturing multiple images. This helps reduce the possibility of inaccurate first liquid level height values ​​due to the influence of other factors in a single capture, thereby improving the accuracy of the first liquid level height detection. Of course, in specific applications, as an alternative implementation, the first liquid level height value can also be obtained by analyzing a single first target image 1011 obtained from a single capture.

[0151] In one implementation, the aforementioned control camera device 400 captures images of the second sample container 20 located at the liquid level detection position to obtain a second target image 1012. Based on the second target image 1012, a second liquid level height value is obtained. This includes: the control camera device 400 capturing images of the second sample container 20 located at the liquid level detection position at least twice to obtain at least two second target images 1012; and obtaining the second liquid level height value based on the at least two second target images 1012. In this embodiment, the principle of obtaining the second liquid level height value by capturing multiple images is the same as the principle of obtaining the first liquid level height value by capturing multiple images, and will not be detailed here. Of course, in specific applications, as an alternative implementation, the second liquid level height value can also be obtained by analyzing a single second target image 1012 obtained from a single capture.

[0152] As one implementation, obtaining the first liquid level height value based on at least two first target images 1011 includes: obtaining at least two first initial height values ​​corresponding one-to-one with each of the at least two first target images 1011, and averaging the at least two first initial height values ​​to obtain the first liquid level height value. Similarly, obtaining the second liquid level height value based on at least two second target images 1012 includes: obtaining at least two second initial height values ​​corresponding one-to-one with each of the at least two second target images 1012, and averaging the at least two second initial height values ​​to obtain the second liquid level height value. In this implementation, the first liquid level height value is obtained by averaging multiple first initial height values ​​obtained from multiple first target images 1011; the second liquid level height value is obtained by averaging multiple second initial height values ​​obtained from multiple second target images 1012. This method is simple and helps ensure the accuracy of both the first and second liquid level height values.

[0153] In one implementation, the aforementioned control camera device 400 takes at least two images of the first sample container 20 located at the liquid level detection position to obtain at least two first target images 1011, including: the control camera device 400 takes three images of the first sample container 20 located at the liquid level detection position to obtain three first target images 1011. The aforementioned averaging of at least two first initial height values ​​to obtain a first liquid level height value includes: averaging three first initial height values ​​to obtain a first liquid level height value. The aforementioned control camera device 400 takes at least two images of the second sample container 20 located at the liquid level detection position to obtain at least two second target images 1012, including: the control camera device 400 takes three images of the second sample container 20 located at the liquid level detection position to obtain three second target images 1012. The aforementioned averaging of at least two second initial height values ​​to obtain a second liquid level height value includes: averaging three second initial height values ​​to obtain a second liquid level height value. In this implementation scheme, the first liquid level height and the second liquid level height are obtained by averaging the initial height values ​​obtained from three shots. Of course, in specific applications, the first liquid level height and the second liquid level height can also be obtained by averaging the initial height values ​​obtained from two, four, or more shots.

[0154] The above scheme obtains the first and second liquid level heights using an average value method. However, in specific applications, the average value method is not the only option. For example, as an alternative implementation, obtaining the first liquid level height based on at least two first target images 1011 includes: obtaining three initial height values ​​corresponding to each of the three first target images 1011, and using the first initial height value other than the maximum and minimum values ​​as the first liquid level height. Similarly, obtaining the second liquid level height based on at least two second target images 1012 includes: obtaining three initial height values ​​corresponding to each of the three second target images 1012, and using the second initial height value other than the maximum and minimum values ​​as the second liquid level height. This alternative implementation mainly obtains the first and second liquid level heights using a median-based method (or extreme value removal method). Of course, in specific applications, the first liquid level height can be obtained by taking the median value of five or seven initial height values, and the second liquid level height can be obtained by taking the median value of five or seven initial height values.

[0155] Alternatively, as an alternative implementation, obtaining the first liquid level height value based on at least two first target images 1011 includes: obtaining at least four first initial height values ​​corresponding one-to-one with each of the at least four first target images 1011; and averaging the two first initial height values ​​excluding the maximum and minimum values ​​to obtain the first liquid level height value. Similarly, obtaining the second liquid level height value based on at least two second target images 1012 includes: obtaining at least four second initial height values ​​corresponding one-to-one with each of the at least four second target images 1012; and averaging the two second initial height values ​​excluding the maximum and minimum values ​​to obtain the second liquid level height value. This alternative implementation obtains the first and second liquid level height values ​​respectively through extreme value removal and averaging methods.

[0156] As one implementation, before obtaining a first conversion model characterizing the relationship between the volume of liquid and the liquid level in the first type of sample container 20 based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, the control method further includes: obtaining a first range based on the maximum and minimum values ​​among all first initial height values ​​obtained from at least two first target images 1011, and dividing the first range by the first liquid level height value to obtain a first ratio; obtaining a second range based on the maximum and minimum values ​​among all second initial height values ​​obtained from at least two second target images 1012, and dividing the second range by the second liquid level height value to obtain a second ratio;

[0157] If both the first ratio and the second ratio are less than or equal to the first threshold, the first conversion model calibration of the first conversion model calibration process is deemed successful. Based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, a first conversion model is obtained to characterize the relationship between the volume and liquid level height of the liquid within the first type of sample container 20. If either the first ratio or the second ratio is greater than the first threshold, the first conversion model calibration of the first conversion model calibration process is deemed unsuccessful. In this embodiment, the success of the first conversion model calibration is determined by comparing the first range, the second range, and the first threshold. When the first range or the second range is too large, it indicates a large error in the initial height value obtained from the image, and the calibration is deemed unsuccessful. When both the first range or the second range are less than or equal to the first threshold, it indicates a small error in the initial height value obtained from the image, and the calibration is deemed successful.

[0158] The above scheme uses the range and the calculated first liquid level height value and second liquid level height value to determine whether the first conversion model calibration is successful. Of course, in specific applications, other methods can also be used to determine whether the first conversion model calibration is successful. For example, as an alternative implementation, before obtaining the first conversion model to characterize the relationship between the volume and liquid level height of the liquid in the first type of sample container 20 based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, the control method further includes: comparing the maximum and minimum values ​​of all first initial height values ​​obtained from at least two first target images 1011 with the first liquid level height value one by one; comparing the maximum and minimum values ​​of all second initial height values ​​obtained from at least two second target images 1012 with the second liquid level height value one by one; if the difference between the maximum value and the first liquid level height value, the difference between the first liquid level height value and the minimum value of all first initial height values, and the difference between the maximum value and the second liquid level height value of all second initial height values ​​are less than or equal to ... control method further includes: comparing the maximum and the minimum value of all first initial height values ​​obtained from at least two first target images 1011 with the first liquid level height value; if the difference between the maximum value and the first liquid level height value, the difference between the first liquid level height value and the minimum value of all first initial height values, and the difference between the maximum value and the second liquid level height value of all second initial height values ​​are less than or equal to the first liquid level height value, the control method further includes: comparing the maximum and the minimum value of all first initial height values ​​obtained from at least two first target images 1011 with the second liquid level height value, the control method further includes: comparing the maximum and the minimum value of all first initial height values ​​obtained from at least two first target images 1012 with the second liquid level height value, the control method further includes If the difference between the second liquid level value and the minimum value among all second initial height values ​​is less than or equal to the second threshold, then the first conversion model calibration of the first conversion model calibration process is deemed successful. Based on the first volume, the first liquid level value, the second volume, and the second liquid level value, a first conversion model is obtained to characterize the relationship between the volume and liquid level of the liquid in the first type of sample container 20. If at least one of the differences between the maximum value and the first liquid level value among all first initial height values, the differences between the first liquid level value and the minimum value among all first initial height values, the differences between the maximum value and the second liquid level value among all second initial height values, and the differences between the second liquid level value and the minimum value among all second initial height values ​​is greater than the second threshold, then the first conversion model calibration of the first conversion model calibration process is deemed unsuccessful. In this embodiment, the success of the first conversion model calibration is determined by comparing the differences between the maximum and minimum values ​​and the liquid level values ​​with the second threshold. When the difference is too large, it indicates that the error of the initial height value obtained from the photograph is relatively large, and the calibration is deemed unsuccessful. When the difference is less than or equal to the first threshold, it means that the error of the initial height value obtained by shooting is relatively small, and the calibration is considered successful.

[0159] In the above scheme, by sequentially transferring reference liquids containing two different known volumes to a liquid level detection position using two sample containers 20 of the same type or the same sample container 20, a first conversion model is obtained to characterize the relationship between the volume of liquid and the liquid level height within that type of sample container 20. Of course, in specific applications, it is also possible to transfer reference liquids containing three or more different known volumes to a liquid level detection position using three or more sample containers 20 of the same type or the same sample container 20, to obtain a first conversion model to characterize the relationship between the volume of liquid and the liquid level height within that type of sample container 20. For example, as an alternative implementation, before obtaining the first conversion model to characterize the relationship between the volume of liquid and the liquid level height within a first type of sample container 20 based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value, the first conversion model calibration process further includes: controlling the sample container transfer device 300 to transfer a third sample container 20 containing a third volume of reference liquid to a liquid level detection position; and controlling the liquid level detection device to perform liquid level detection on the third sample container 20 located at the liquid level detection position to obtain a third liquid level height value corresponding to the third volume. The aforementioned first conversion model, derived from the first volume, first liquid level height, second volume, and second liquid level height, characterizes the relationship between the volume of liquid and the liquid level height within the first type of sample container 20. This model includes: obtaining the first conversion model based on the first volume, first liquid level height, second volume, second liquid level height, third volume, and third liquid level height; wherein the third volume is greater than or less than the first volume, and the third volume is greater than or less than the second volume; the third sample container 20, the first sample container 20, and the second sample container 20 constitute three first-type sample containers 20; or, the third sample container 20, at least one of the first sample container 20, and the second sample container 20 constitutes the same first-type sample container 20. In this alternative implementation, reference liquids containing three different known volumes are sequentially transferred to a liquid level detection position from three sample containers 20 of the same type or from the same sample container 20 for detection, thereby obtaining the first conversion model characterizing the relationship between the volume of liquid and the liquid level height within that type of sample container 20. Of course, in specific applications, as an alternative implementation, four or more sample containers 20 of the same type or the same sample container 20 are used to successively transfer reference liquids containing four or more different known volumes to the liquid level detection position for detection, thereby obtaining a first conversion model to characterize the relationship between the volume of the liquid in the sample container 20 and the liquid level height.

[0160] In one implementation, before the control sample container transfer device 300 transfers the first sample container 20 containing a first volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the first volume based on information input by the operator through the display screen 101; before the control sample container transfer device 300 transfers the second sample container 20 containing a second volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the second volume based on information input by the operator through the display screen 101. In this implementation, the first volume and the second volume are input through a human-computer interaction method. Of course, in specific applications, the first volume and the second volume can also be obtained in other ways. For example, as an alternative implementation, the first volume and the second volume can also be obtained by scanning a code.

[0161] As one implementation, before the control sample container transfer device 300 transfers the first sample container 20 containing a first volume of reference liquid to the liquid level detection position, the control method further includes: controlling the display screen 101 to display at least one of the following information: information indicating that the operator should place the first sample container 20 and the second sample container 20 into the target position of the sample analysis device 10; and information indicating that the operator should input the first volume and the second volume on the display screen 101. This implementation can prompt the operator to place the first sample container 20 and the second sample container 20 into the target position via an interface prompt, and prompt the operator to input the first volume and the second volume via an interface prompt.

[0162] As one implementation, the control method further includes: controlling the execution of the first conversion model calibration process when any of the following first preset conditions are met: obtaining information for executing the first conversion model calibration process according to the instructions input by the operator through the human-machine interaction device; obtaining information for characterizing the replacement or addition of sample container type 20; obtaining information on the position change of the liquid level detection position and / or liquid level detection device; obtaining information on the failure of the first conversion model calibration process; reaching a preset time point of a preset cycle; the cumulative running time of the liquid level detection device since the last execution of the first conversion model calibration process reaching a preset time; the cumulative number of liquid level detections performed by the liquid level detection device since the last execution of the first conversion model calibration process reaching a preset number; wherein, the human-machine interaction device includes at least one of a display screen 101, a voice interaction component, a button, a knob, and a push button. The first conversion model calibration process can be manually triggered or automatically controlled to execute after the preset conditions are met.

[0163] As one implementation, the above control method further includes: controlling the display screen 101 to display the conversion model calibration function option on the function interface; and executing the steps of the conversion model calibration process when the conversion model calibration function option is triggered. In this embodiment, the conversion model calibration process can be triggered by the interface, for example, by clicking the conversion model calibration function option on the function interface to trigger the execution of the conversion model calibration process steps, which is simple to operate.

[0164] In one implementation, the above control method further includes the following detection process steps: controlling the sample container transfer device 300 to transfer the fourth sample container 20 containing the first sample to be tested 30 to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the fourth sample container 20 located at the liquid level detection position to obtain the fourth liquid level height value of the first sample to be tested 30 in the fourth sample container 20; obtaining the fourth volume of the first sample to be tested 30 in the fourth sample container 20 according to the fourth liquid level height value and the first conversion model; wherein, the fourth liquid level height value is the total liquid level height value of the first sample to be tested 30 in the fourth sample container 20; the fourth volume is the total volume of the first sample to be tested 30 in the fourth sample container 20; the fourth sample container 20 and the first sample container 20 are two first-type sample containers 20. In this implementation scheme, after calibrating and obtaining a conversion model for a certain type of sample container 20, when testing a sample 30 loaded in that type of sample container 20, as long as the liquid level of the sample 30 inside the sample container 20 is detected, the total liquid volume of the sample can be accurately calculated using the conversion model.

[0165] In one implementation, controlling the sample container transfer device 300 to transfer the fourth sample container 20 containing the first test sample 30 to the liquid level detection position includes: controlling the sample container transfer device 300 to transfer the fourth sample container 20 containing the first test sample 30, after the first test sample 30 has been centrifuged into an upper liquid 31, an intermediate liquid 32, and a lower liquid 33, to the liquid level detection position, wherein the lower liquid 33 contains red blood cells. The above detection process further includes: performing liquid level detection on the fourth sample container 20 located at the liquid level detection position using the liquid level detection device to obtain a fifth liquid level height value of the lower liquid 33 within the fourth sample container 20; obtaining a fifth volume of the lower liquid 33 within the fourth sample container 20 based on the fifth liquid level height value and a first conversion model; and obtaining the hematocrit of the first test sample 30 based on the fourth and fifth volumes. The intermediate liquid 32 contains at least platelets and / or white blood cells. The intermediate liquid 32 is also called the white membrane layer, the upper liquid 31 is plasma or serum, and the lower liquid 33 is red blood cells. The sample 30 to be tested, collected from a human or animal and stored in sample container 20, is a whole blood sample. In this embodiment, after calibrating and obtaining a conversion model for a certain type of sample container 20, when testing the sample 30 loaded in that type of sample container 20, as long as the total liquid level and the red blood cell layer liquid level of the sample 30 in that type of sample container 20 are detected, the hematocrit can be accurately calculated using the conversion model.

[0166] In one implementation, the sample measuring device 200 is used to aspirate at least a portion of the upper liquid 31 from the sample container 20, which contains the sample 30 to be tested and which has been centrifuged into an upper liquid 31, a middle liquid 32, and a lower liquid 33, and distribute it to the reaction vessel for measurement. Specifically, the sample measuring device 200 is used to measure the upper liquid 31 in the centrifuged sample 30. In this embodiment, the sample measuring device 200 is used to perform the measurement on the upper liquid 31 obtained after centrifuging the sample 30. Of course, in specific applications, as an alternative implementation, other measuring devices can be set up in the sample analysis system to perform the measurement on the middle liquid and / or the lower liquid 33; or, as another alternative implementation, other measuring devices can be set up in the sample analysis system to perform the measurement on the uncent-centrifuged sample 30 (i.e., whole blood sample).

[0167] As one implementation method, the control method further includes: controlling the display screen 101 to display the total volume and / or hematocrit of the first sample 30 to be tested within the fourth sample container 20. This improves the efficiency and intuitiveness for operators in verifying liquid volume and hematocrit.

[0168] In one implementation, controlling the liquid level detection device to perform liquid level detection on the fourth sample container 20 located at the liquid level detection position to obtain a fourth liquid level height value and a fifth liquid level height value includes: controlling the camera device 400 to take a picture of the fourth sample container 20 located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image; the control method further includes: controlling the display screen 101 to display the third target image; wherein, the third target image includes at least an image showing the entire height of one side of the fourth sample container 20 in a two-dimensional and / or three-dimensional form, or at least an image showing all the first test samples 30 in the fourth sample container 20 in a two-dimensional and / or three-dimensional form, or at least an image showing the liquid level of the upper layer liquid 31, the liquid level of the middle layer liquid 32 and the liquid level of the lower layer liquid 33 in the fourth sample container 20, or at least an image showing the bottom, middle part and top of the fourth sample container 20 in a two-dimensional and / or three-dimensional form.

[0169] In practical applications, there are many types of sample containers 20. Different types of sample containers 20 will have different shapes and dimensional parameters. Differences in the shape and size of the sample container 20 will affect the accuracy of the conversion result from height to volume, thus affecting the accuracy of the liquid volume detection result and the hematocrit detection result of the sample 30. Specifically, the impact of the shape and size of the sample container 20 on the accuracy of the liquid volume calculation is mainly reflected in the following points: 1) Different sample containers 20 have different inner diameters, making it difficult to achieve a uniform inner diameter. 2) Draft angles exist during the manufacturing of the sample container 20, resulting in inconsistencies between the inner diameter of the nozzle and the bottom of the sample container 20. 3) The bottom shape of the sample container 20 is a non-standard hemisphere, making it difficult to model and calculate the volume of the bottom of the sample container 20. Therefore, since the sample container 20 has an irregular shape, it is necessary to obtain the conversion relationship (i.e., conversion model) between the liquid level height in the sample container 20 and the volume of the sample 30 to be tested before conducting liquid volume detection and hematocrit detection, so as to ensure the accuracy of the conversion result from height to volume.

[0170] As one implementation method, after the sample analysis device 10 is installed, a conversion model corresponding to the type of sample container 20 is pre-stored in the sample analysis device 10. During the user's use, the updated conversion model is obtained by performing a conversion model calibration process on the user's end.

[0171] In one implementation, the control method further includes the following steps in the conversion model calibration process: controlling the sample container transfer device 300 to transfer the fifth sample container 20 containing a sixth volume of reference liquid to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the fifth sample container 20 located at the liquid level detection position to obtain a sixth liquid level height value of the reference liquid in the fifth sample container 20; controlling the sample container transfer device 300 to transfer the sixth sample container 20 containing a seventh volume of reference liquid to the liquid level detection position, wherein the sixth volume is greater than or less than the seventh volume; controlling the liquid level detection device to perform liquid level detection on the sixth sample container 20 located at the liquid level detection position to obtain a seventh liquid level height value of the reference liquid in the sixth sample container 20; and obtaining a second conversion model for characterizing the relationship between the volume and liquid level height of the liquid in the second type of sample container 20 based on the sixth volume, the sixth liquid level height value, the seventh volume, and the seventh liquid level height value. The control method also includes the following detection process steps: controlling the sample container transfer device 300 to transfer the seventh sample container 20, which contains the second test sample 30 and has been centrifuged into upper liquid 31, middle liquid 32, and lower liquid 33, to the liquid level detection position, wherein the lower liquid 33 contains red blood cells; controlling the liquid level detection device to perform liquid level detection on the seventh sample container 20 located at the liquid level detection position, obtaining the eighth liquid level height value of the second test sample 30 in the seventh sample container 20 and the ninth liquid level height value of the lower liquid 33 in the seventh sample container 20; obtaining the eighth volume of the second test sample 30 in the seventh sample container 20 based on the eighth liquid level height value and the second conversion model; obtaining the eighth volume of the second test sample 30 in the seventh sample container 20 based on the ninth liquid level height value and the second conversion model; and obtaining the eighth volume of the second test sample 30 in the seventh sample container 20 based on the ninth liquid level height value and the second conversion model. The conversion model yields the ninth volume of the lower layer liquid 33 within the seventh sample container 20; based on the eighth and ninth volumes, the hematocrit of the second sample 30 is obtained; wherein, the eighth liquid level height is the total liquid level height of the second sample 30 within the seventh sample container 20; the eighth volume is the total volume of the second sample 30 within the seventh sample container 20; the fifth, sixth, and seventh sample containers 20 are three second-type sample containers 20, or the fifth and sixth sample containers 20 are the same second-type sample container 20, and the seventh sample container 20 is another second-type sample container 20; the first-type sample container 20 and the second-type sample container 20 differ in at least one of the following: shape, size. This embodiment obtains the liquid volume detection results and the hematocrit detection results in a manner applicable to situations where the sample analysis device 10 employs at least two types of sample containers 20. In the prior art, it was difficult to measure the inner diameter of all sample containers 20, making it difficult to accurately calculate the volume of the sample 30 to be tested and the hematocrit of red blood cells in each different type of sample container 20 based on the liquid level.In this implementation scheme, different conversion models are obtained by calibrating different types of sample containers 20. Thus, in practical applications, only the type information of the sample container 20 and the liquid level of the sample 30 to be tested within the sample container 20 are needed to calculate the total liquid volume and hematocrit of the sample 30 based on the conversion model. The type of sample container 20 can be obtained through a barcode reader or visual imaging, or by feeding different types of sample containers 20 separately into different feeding areas.

[0172] In one implementation, the above-described control sample container transport device 300 transports a first sample container 20 containing a first volume of reference liquid to a liquid level detection position, including: the control sample container transport device 300 transports the first sample container 20 from the first storage area of ​​the sample management device 100 to the liquid level detection position. The above-described control sample container transport device 300 transports a second sample container 20 containing a second volume of reference liquid to a liquid level detection position, including: the control sample container transport device 300 transports the second sample container 20 from the first storage area to the liquid level detection position. The above-described control sample container transport device 300 transports a fourth sample container 20 containing a first test sample 30 to a liquid level detection position, including: the control sample container transport device 300 transports the fourth sample container 20 from the first storage area to the liquid level detection position. The above-described control sample container transport device 300 transports a fifth sample container 20 containing a sixth volume of reference liquid to a liquid level detection position, including: the control sample container transport device 300 transports the fifth sample container 20 from the second storage area of ​​the sample management device 100 to the liquid level detection position. The aforementioned control sample container transfer device 300 transfers the sixth sample container 20, containing a seventh volume of reference liquid, to the liquid level detection position, including: the control sample container transfer device 300 transferring the sixth sample container 20 from the second storage area to the liquid level detection position. The aforementioned control sample container transfer device 300 also transfers the seventh sample container 20, containing a second sample to be tested 30, to the liquid level detection position, including: the control sample container transfer device 300 transferring the seventh sample container 20 from the second storage area to the liquid level detection position. The first storage area and the second storage area are located in two different areas of the sample management device 100. The first storage area is used for loading first-type sample containers 20, and the second storage area is used for loading second-type sample containers 20. In this embodiment, different types of sample containers 20 are loaded in separate zones to achieve identification of different types of sample containers 20.

[0173] As another implementation, before obtaining the first conversion model characterizing the relationship between the volume of liquid and the liquid level in the first type of sample container 20 based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes: obtaining information that the first sample container 20 belongs to the first type of sample container 20 based on feedback information from the identification device's identification of the first sample container 20; and obtaining information that the second sample container 20 belongs to the first type of sample container 20 based on feedback information from the identification device's identification of the second sample container 20. Before obtaining the fourth volume of the first sample to be tested 30 in the fourth sample container 20 based on the fourth liquid level value and the first conversion model, the control method further includes: obtaining information that the fourth sample container 20 belongs to the first type of sample container 20 based on feedback information from the identification device's identification of the fourth sample container 20. Before obtaining the second conversion model characterizing the relationship between the volume and liquid level of the liquid in the second type of sample container 20 based on the sixth volume, sixth liquid level value, seventh volume, and seventh liquid level value, the control method further includes: obtaining information that the fifth sample container 20 belongs to the second type of sample container 20 based on feedback information from the identification device's identification of the fifth sample container 20; and obtaining information that the sixth sample container 20 belongs to the second type of sample container 20 based on feedback information from the identification device's identification of the sixth sample container 20. Before obtaining the eighth volume of the second test sample 30 in the seventh sample container 20 based on the eighth liquid level value and the second conversion model, the control method further includes: obtaining information that the seventh sample container 20 belongs to the second type of sample container 20 based on feedback information from the identification device's identification of the seventh sample container 20. The identification device can be a barcode reader or a vision camera. This embodiment distinguishes different types of sample containers 20 through information identification.

[0174] As one embodiment for obtaining the total liquid volume and hematocrit based on the total liquid level and the height of the lower liquid layer 33, obtaining the total liquid volume of the sample to be tested 30 in the sample container 20 based on the total liquid level includes: obtaining the total liquid volume of the sample to be tested 30 in the sample container 20 based on the total liquid level and a first conversion model pre-stored in the sample analysis device 10, wherein the first conversion model is a conversion relationship between the liquid level in the sample container 20 and the volume of the sample to be tested 30. Obtaining the hematocrit of the sample to be tested 30 in the sample container 20 based on the total liquid level and the height of the lower liquid layer 33 includes: obtaining the hematocrit of the sample to be tested 30 in the sample container 20 based on the total liquid level, the height of the lower liquid layer 33, and the first conversion model. Specifically, the detection methods for liquid volume and hematocrit are as follows: First, based on the overall image of the sample 30 to be tested, the total liquid level and the height of the lower liquid 33 are obtained. Then, based on the total liquid level and the first conversion model of the pre-stored sample analysis device 10, the total volume (i.e., total liquid volume) of the sample 30 to be tested is calculated. Next, based on the height of the lower liquid 33 and the first conversion model, the volume of the lower liquid 33 is calculated. Finally, based on the total volume of the sample 30 to be tested and the volume of the lower liquid 33, the hematocrit of the sample 30 is obtained, thus completing the detection of the liquid volume and hematocrit of the sample 30. This implementation method for obtaining the total liquid volume and hematocrit of the sample 30 is applicable when the sample analysis device 10 uses only one type of sample container 20.

[0175] As one implementation method, this implementation method establishes a height-volume conversion model by calibration (conversion model calibration) (i.e., for a specified sample container 20, the height is identified by adding a specified amount of reference liquid to the sample container 20). When actually measuring the sample 30 to be tested, the total liquid level height and red blood cell liquid level height obtained from the sample 30 to be tested are substituted into the conversion model to obtain the total liquid volume and HCT.

[0176] A first aspect of this invention also provides a sample analysis device 10, which includes a sample management device 100, a sample measurement device 200, a sample container transfer device 300, and a control device 500. The sample management device 100 is used at least to place a sample container 20 containing a sample to be tested 30 into the sample container 20 for loading the sample 30. The sample measurement device 200 is used to aspirate at least a portion of the sample 30 from the sample container 20 containing the sample 30 for measurement. The sample container transfer device 300 is used to transfer the sample container 20 containing the sample 30 from the sample management device 100 to the sample measurement device 200. The sample management device 100 can be used to load the sample 30, and the sample container 20 containing the sample 30 can be placed in the sample management device 100 by an operator or a robot. The sample container transfer device 300 is used to transfer the sample 30. The sample measurement device 200 is used to perform measurement tasks on the sample 30.

[0177] In one embodiment, the sample measuring device 200 is used to measure the centrifuged sample 30, that is, the sample measuring device 200 is used to aspirate at least a portion of the centrifuged sample 30 from the sample container 20 containing the sample 30 after centrifugation and distribute it to the reaction container for reaction and measurement.

[0178] In one embodiment, the sample determination device 200 includes a sample dispensing mechanism 220 and a determination mechanism 230. The sample dispensing mechanism 220 is used to aspirate at least a portion of the upper liquid 31 from the sample container 20, which contains the sample to be tested 30 and has been centrifuged into upper liquid 31, middle liquid 32, and lower liquid 33, and dispense it into the reaction container. The middle liquid 32 contains platelets and / or white blood cells. The determination mechanism 230 is used to determine the test solution in the reaction container, which is at least made up of the aspirated upper liquid 31 and reagents.

[0179] In one implementation, the sample analysis device 10 further includes a camera device 400, which is used to take a picture of the sample container 20 before the sample dispensing mechanism 220 draws at least a portion of the upper liquid 31 from the sample container 20. The control device 500 is further configured to: obtain a target image based on feedback information from the camera device 400's image-taking action; and obtain at least one of the following information based on the target image: the total volume of the sample 30 to be tested in the sample container 20, the hematocrit of the sample 30 to be tested in the sample container 20, the hemolysis index of the sample 30 to be tested in the sample container 20, the jaundice index of the sample 30 to be tested in the sample container 20, and the lipemia index of the sample 30 to be tested in the sample container 20. The camera device 400 is one type of liquid level detection device. In this embodiment, at least one of the hematocrit detection result, liquid volume detection result, hemolysis detection result, jaundice detection result, and lipemia detection result is obtained through the target image, and the detection method is simple.

[0180] In one embodiment, the control device 500 is further configured to obtain at least two of the following information based on the target image: the total volume of the sample 30 to be tested in the sample container 20, the hematocrit of the sample 30 to be tested in the sample container 20, the hemolysis index of the sample 30 to be tested in the sample container 20, the jaundice index of the sample 30 to be tested in the sample container 20, and the lipemia index of the sample 30 to be tested in the sample container 20.

[0181] In one implementation, the control device 500 is further configured to obtain, based on the target image, all of the following information: the total volume of the sample 30 to be tested in the sample container 20, the hematocrit of the sample 30 to be tested in the sample container 20, the hemolysis index of the sample 30 to be tested in the sample container 20, the jaundice index of the sample 30 to be tested in the sample container 20, and the lipid index of the sample 30 to be tested in the sample container 20.

[0182] In one implementation, the target image includes at least an image showing the entire height of one side of the sample container 20 in a two-dimensional and / or three-dimensional form, or at least an image showing all the test samples 30 inside the sample container 20 in a two-dimensional and / or three-dimensional form, or at least an image showing the liquid surface of the upper liquid 31, the liquid surface of the middle liquid 32, and the liquid surface of the lower liquid 33 inside the sample container 20, or at least an image showing all the upper liquid 31, all the middle liquid 32, and all the lower liquid 33 inside the sample container 20 in a two-dimensional and / or three-dimensional form, or at least an image showing the bottom, middle part, and at least one side of the top of the sample container 20 in a two-dimensional and / or three-dimensional form. The second target image 1012 is a full-view image of the sample container 20 (it can be a full-view image of the sample container 20 with or without a cap, a full-view image of the sample container 20 with or without a stopper), which can at least show the entire height information of the sample container 20; or the second target image 1012 is a full-view image of the sample 30 to be tested inside the sample container 20, which can at least show the height information of the three liquid layers or the entire height information of the sample 30 to be tested inside the sample container 20. For ease of description and understanding, the second target image 1012 can also be referred to as a full-view image of the sample 30 to be tested.

[0183] In one implementation, the imaging device 400 performs the imaging action on the sample container 20 by: directly capturing an image of the sample container 20 from the side or indirectly capturing an image of the sample container 20 through the reflector 600. That is, the imaging device 400 is used to directly or indirectly capture images of the sample container 20 and / or the sample 30 to be tested inside the sample container 20.

[0184] In one implementation, the sample analysis device 10 further includes a reflector 600, which is used to reflect an image, at least in a two-dimensional and / or three-dimensional form, showing the entire sample container 20 to the camera device 400 when the camera device 400 performs an image capture operation. The image capture operation performed by the camera device 400 on the sample container 20 includes: the camera device 400 indirectly captures an image of the sample container 20 through the reflector 600. Of course, in specific applications, the sample analysis device 10 may not include the reflector 600. For example, as an alternative implementation, the image capture operation performed by the camera device 400 on the sample container 20 includes: the camera device 400 directly captures an image of the sample container 20 from the side of the sample container 20.

[0185] In one implementation, the imaging device 400 is a camera, and the sample analysis device 10 also includes a supplementary lighting component 800. The camera captures the entire view of the sample 30 to be tested from the side of the sample container 20. The supplementary lighting component 800 is mainly used to provide supplementary lighting to the entire view of the sample 30 to be tested within the camera's field of view, so as to illuminate at least all the samples 30 to be tested within the sample container 20.

[0186] In one embodiment, the sample container transfer device 300 includes a transport track 310, a first sample container scheduling mechanism 320, and a sample container transfer device 330. The transport track 310 is used to transport a sample holder with a single first container position, the first container position being used to place a single sample container 20. The first sample container scheduling mechanism 320 is used to schedule the sample container 20, which is placed in the sample management device 100 and loaded with the sample to be tested 30, to the sample holder located on the transport track 310.

[0187] In one implementation, a sample container transfer device 330 is located between the transport track 310 and the sample measuring device 200. It is used to pick up the sample containers 20 one by one from the sample holders transported by the transport track 310 and place them onto the sample rack inside the sample container transfer device 330. The sample containers 20 are then transported to the sample measuring device 200 for measurement via the sample rack. The transport track 310 is the main transport track 310 of the sample analysis equipment 10, and the sample measuring device 200 is the sample processing device in the sample analysis equipment 10 used to perform analytical functions on the samples 30 to be tested. The sample container transfer device 330, also known as an RBU module, is mainly used to pick up the sample containers 20 one by one from the sample holders transported by the transport track 310 and place them onto the sample rack inside the sample container transfer device 330. The sample containers 20 are then transported to the sample measuring device 200 for measurement via the sample rack. In this implementation scheme, the sample container transfer device 330 is set up to achieve the effect of transferring the sample container 20 from the sample holder to the sample rack for transmission. Thus, without changing the structure of the transport track 310 and the sample measuring device 200, the transmission function of the sample to be tested 30 between the transport track 310 with sample holder transmission function and the sample measuring device 200 with sample rack transmission function can be realized.

[0188] In one implementation, the sample container transfer device 330 includes a sample seat scheduling mechanism, a second sample container scheduling mechanism, and a sample rack scheduling mechanism. The sample seat scheduling mechanism is used to transport sample seats, which are conveyed to the sample container transfer device 330 by the conveyor rail 310, to the racking position. The second sample container scheduling mechanism is used to schedule the sample containers 20 on the sample seats located at the racking position to the sample racks provided by the sample rack scheduling mechanism. The sample racks have at least two second container positions, each for placing a single sample container 20. The sample rack scheduling mechanism is used to schedule the sample racks loaded with sample containers 20, and the sample containers 20 are loaded with samples 30 to be tested, to the sample determination device 200. The sample seat is the transport carrier for a single sample container 20, and the sample rack is the transport carrier for multiple sample containers 20. The sample seat scheduling mechanism is used, on the one hand, to connect the sample container transfer device 330 with the conveyor rail 310, and on the other hand, to facilitate the transport of sample seats within the sample container transfer device 330. The sample rack scheduling mechanism serves two purposes: firstly, it connects the sample container transfer device 330 to the sample measurement device 200; secondly, it facilitates the transfer of the sample rack within the sample container transfer device 330. The second sample container scheduling mechanism serves two purposes: firstly, it enables interaction between the sample seat scheduling mechanism and the sample rack scheduling mechanism; and thirdly, it facilitates the transfer of the sample container 20 between the sample seat and the sample rack.

[0189] In one embodiment, the sample analysis device 10 further includes a centrifuge device 900. The centrifuge device 900 is used to centrifuge the sample container 20 containing the sample to be tested 30, causing the sample 30 to separate into an upper liquid layer 31, a middle liquid layer 32, and a lower liquid layer 33. The sample management device 100 is used to load the sample container 20 containing the sample to be tested 30 that has not yet undergone centrifugation, and to load the sample container 20 containing the sample to be tested 30 that has already undergone centrifugation, thus loading the centrifuged sample 30. The sample container transfer device 300 is used at least to transport a sample container 20, loaded with an uncent sample 30 to be tested and output from the sample management device 100, to the centrifuge device 900 for centrifugation; to transport a sample container 20, loaded with a centrifuged sample 30 to be tested and output from the centrifuge device 900, to the sample determination device 200; and to transport a sample container 20, loaded with a centrifuged sample 30 to be tested and output from the sample management device 100, to the sample determination device 200. In this embodiment, the sample analysis device 10 has the function of centrifuging the sample 30 to be tested, which can meet the sample loading and determination requirements of both uncent and centrifuged samples. Of course, in specific applications, as an alternative implementation, the sample analysis device 10 may not be equipped with a centrifuge device 900, and the sample 30 to be tested may be centrifuged in other devices before being placed on the sample analysis device 10 for determination.

[0190] In one embodiment, the camera device 400 is used to perform a shooting action on the sample container 20 that is transported to the shooting position by the transport track 310. The shooting position is located on the transport track 310, on the path of transporting the sample container 20 by the transport track 310, and between the first sample scheduling mechanism and the sample container transfer device 330.

[0191] In one implementation, the imaging position is located between the centrifugation device 900 and the sample measuring device 200.

[0192] In one implementation, the imaging position is located between the centrifugation device 900 and the sample container transfer device 330.

[0193] In one embodiment, the camera device 400 is disposed on the sample container transfer device 300 and located beside the centrifugation device 900.

[0194] In one embodiment, the sample determination apparatus 200 includes a sample dispensing mechanism 220, a reagent dispensing mechanism 250, an incubation mechanism 240, and a determination mechanism 230. The sample dispensing mechanism 220 is used to draw a sample 30 to be tested from a sample container 20 located in the sample aspiration channel 210 and dispense at least a portion of the drawn sample 30 into a reaction container. The reagent dispensing mechanism 250 is used to draw reagents from a reagent container and dispense at least a portion of the drawn reagents into the reaction container. The incubation mechanism 240 is used to incubate the sample 30 to be tested or a mixture of sample and reagent in the reaction container. The determination mechanism 230 is used to determine the reaction solution prepared from the sample 30 to be tested and the reagent in the reaction container.

[0195] In one implementation, the sample dispensing mechanism 220 includes a sample needle, a first suction / dispensing driving component, and a first motion driving component; the sample needle is used to aspirate and dispense samples. The first suction / dispensing driving component provides driving force for the sample needle to aspirate and dispense samples. The first motion driving component drives the sample needle to move in two-dimensional or three-dimensional space, so that the sample needle moves to different positions, such as a standby position, a suction position, a sample dispensing position, a cleaning position, etc.

[0196] In one implementation, the first suction / discharge driving component is a syringe. Of course, in specific applications, the arrangement of the first suction / discharge driving component is not limited to this; for example, it could also be a pump or a positive / negative pressure driving component.

[0197] In one implementation, the sample determination device 200 further includes a reaction container supply mechanism 270 and a reaction container transfer mechanism 280. The reaction container supply mechanism 270 provides the reaction container, and the reaction container transfer mechanism 280 transfers the reaction container. During the specific determination process, the sample distribution mechanism 220 distributes the sample 30 to be tested into the reaction container supplied by the reaction container supply mechanism 270. The reaction container transfer mechanism 280 transfers the reaction container supplied by the reaction container supply mechanism 270, after sample addition, to the incubation mechanism 240. The reagent distribution mechanism 250 distributes reagents into the reaction container. The determination mechanism 230 measures the reaction between the sample 30 and the reagents in the reaction container. The reaction container transfer mechanism 280 discards and recycles the completed reaction container. In this embodiment, the reaction container is a disposable container; that is, after carrying the sample 30 and completing the corresponding determination, the reaction container is discarded and recycled without needing to be cleaned and reused within the sample determination device 200, thus simplifying the structure and operating procedure of the sample determination device 200. Of course, in specific applications, the sample determination device 200 can also use a reusable reaction container.

[0198] In one implementation, the sample testing device 200 is used to perform coagulation-related tests on the upper liquid 31 dispensed into the reaction container. The sample testing device 200 is a coagulation analyzer and also includes a reagent tray 230. The reagent dispensing mechanism 250 includes a mixed reagent dispensing assembly 251 and a trigger reagent dispensing assembly 252. The mixed reagent dispensing assembly 251 draws mixed reagents from the mixed reagent container located in the reagent tray 230 and dispenses them into the reaction container. The trigger reagent dispensing assembly 252 draws trigger reagents from the trigger reagent container located in the reagent tray 230 and dispenses them into the reaction container. Each coagulation test includes at least a sample addition period, an incubation period, a trigger reagent period, and a testing period, performed sequentially. During the sample addition period, the sample dispensing mechanism 220 draws the sample 30 to be tested from the sample container 20 and dispenses it into the reaction container to complete the sample addition operation. During the incubation period of the multi-reagent coagulation assay, the mixed reagent dispensing assembly 251 dispenses the mixed reagent from the reagent container into the reaction container, and the incubation mechanism 240 incubates the reaction container containing at least the test sample 30 and the mixed reagent to complete the incubation operation of the multi-reagent coagulation assay. During the incubation period of the single-reagent coagulation assay, the incubation mechanism 240 incubates the reaction container containing at least the test sample 30 to complete the incubation operation of the single-reagent coagulation assay. During the trigger reagent period, the trigger reagent dispensing assembly 252 dispenses the trigger reagent from the reagent container into the reaction container and mixes the reaction container to complete the trigger reagent addition operation. During the measurement period, the measurement mechanism 230 measures the reaction solution in the reaction container to complete the measurement operation. Of course, in specific applications, the sample measurement device 200 is not limited to a coagulation analyzer. For example, as an alternative embodiment, the sample measurement device 200 can also be a biochemical analyzer, an immunoassay analyzer, etc.

[0199] As one implementation method, the processing of the test sample 30 used in the coagulation test includes: using sodium citrate as an anticoagulant, thoroughly mixing the anticoagulant and the test sample 30, and then centrifuging it on a centrifuge 900; due to the different densities of red blood cells, white blood cells, platelets and plasma, the centrifuged test sample 30 is divided into three layers, the bottom layer is mainly red blood cells; the top layer is plasma, which is pale yellow; in the middle of the red blood cells and plasma is a white membrane layer, the main components of which are white blood cells and platelets; the coagulation test mainly involves the absorption and analysis of the plasma on the top layer, and the plasma used for the coagulation test is also called platelet-poor plasma.

[0200] In a preferred embodiment, the sample analysis device 10 mainly uses optical photography to take a picture of the whole picture of the sample 30 after centrifugation, and uses the whole picture information of the sample 30 to calculate the liquid volume detection result, HCT detection result and HIL detection result of the sample 30.

[0201] In practical applications, when measuring the sample 30 to be tested, the total liquid level height h1 and the red blood cell level height h2 are first taken by a side-view camera. These are then substituted into the first conversion model above to obtain the total liquid volume V1 and the red blood cell volume V2. Finally, the hematocrit is obtained according to HCT = V2 / V1.

[0202] Since the conversion model calibration is primarily performed during installation (and also when changing sample container 20), the reference solution used for conversion model calibration can be either mixed plasma or quality control materials. Even in newly opened hospitals that have not yet admitted patients, usage confirmation will be conducted before actual operation. Therefore, the primary conversion model calibration supports mixed plasma from hospitals. Quality control materials are an alternative.

[0203] For the calibrated (converted by the transformation model) sample containers 20, different regions for the sample containers 20 are set in the sample management device 100. This allows different sample containers 20 to be placed in different locations and calculated using different first transformation models. In other words, the region type can be set via a pipeline to specify the placement of a certain type of sample container 20. Thus, if a sample is placed in a region, the first transformation model corresponding to that region is used for calibration.

[0204] Furthermore, in this embodiment of the invention, different types of sample containers 20 have different calibration conversion models, supporting the separate calibration of two or more sample containers 20. In actual sampling, different sample containers 20 are placed in different positions, or different sample containers 20 are identified by visual recognition or barcode scanning to complete the classification of different sample containers 20, and are substituted into the first conversion model of the specified sample container 20 to calculate the total liquid volume and HCT.

[0205] A second aspect of the present invention provides a control method for a sample analysis device 10, the control method comprising the following steps in a detection process: controlling a sample container transfer device 300 to transfer a sample container 20 containing a first sample to be tested 30 to a liquid level detection position; controlling a liquid level detection device to perform liquid level detection on the sample container 20 located at the liquid level detection position to obtain a fourth liquid level height value of the first sample to be tested 30 in the sample container 20; and obtaining a fourth volume of the first sample to be tested 30 in the sample container 20 based on the fourth liquid level height value and a first conversion model; wherein, the first conversion model is used to characterize the relationship between the volume of liquid in the sample container 20 and the liquid level height; the fourth liquid level height value is the total liquid level height value of the first sample to be tested 30 in the sample container 20; and the fourth volume is the total volume of the first sample to be tested 30 in the sample container 20.

[0206] In one implementation, controlling the sample container transfer device 300 to transfer the sample container 20 containing the first test sample 30 to the liquid level detection position includes: controlling the sample container transfer device 300 to transfer the sample container 20 containing the first test sample 30, after the first test sample 30 has been centrifuged into upper liquid 31, middle liquid 32 and lower liquid 33, to the liquid level detection position, wherein the lower liquid 33 contains red blood cells;

[0207] The testing process also includes the following steps:

[0208] The liquid level of the sample container 20 located at the liquid level detection position is detected by the liquid level detection device, and the fifth liquid level height value of the lower liquid 33 in the sample container 20 is obtained.

[0209] Based on the fifth liquid level height value and the first conversion model, the fifth volume of the lower liquid 33 in the sample container 20 is obtained;

[0210] Based on the fourth and fifth volumes, the hematocrit of the first test sample 30 was obtained.

[0211] In one implementation, the liquid level detection device is controlled to perform liquid level detection on the sample container 20 located at the liquid level detection position to obtain the fourth liquid level height value of the first sample 30 to be tested in the sample container 20 and the fifth liquid level height value of the lower liquid 33 in the sample container 20. This includes: controlling the camera device 400 to take a picture of the sample container 20 located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image.

[0212] Apart from the above, other parts and principles of the control method for the sample analysis device 10 provided in the second aspect of the present invention can be referred to the first aspect above, and will not be described in detail here.

[0213] A third aspect of the present invention provides a sample analysis device 10, the sample analysis device 10 comprising:

[0214] The sample measuring device 200 is used to: draw at least a portion of the sample 30 to be tested from the sample container 20 containing the sample 30 to be tested and dispense it into the reaction container, and measure the test solution in the reaction container which is at least made of the sample 30 to be tested and the reagent;

[0215] Sample container transfer device 300, used for transferring sample container 20;

[0216] A liquid level detection device is used to detect the liquid level of a sample container 20 that has been transferred from the sample container transfer device 300 to the liquid level detection position.

[0217] Display screen 101 is used to display at least the functional interface;

[0218] The control device 500 is configured to: control the display to show the conversion model calibration function option on the function interface; when the conversion model calibration function option is triggered, execute the steps of the conversion model calibration process to obtain a conversion model for characterizing the relationship between the volume of liquid and the liquid level in the sample container 20.

[0219] In one implementation, the control device 500 is also configured to perform the following detection process steps:

[0220] The sample container transfer device 300 controls the transfer of the sample container 20 containing the sample 30 to be tested to the liquid level detection position;

[0221] The control liquid level detection device performs liquid level detection on the sample container 20 located at the liquid level detection position to obtain the fourth liquid level height value of the sample 30 to be tested in the sample container 20;

[0222] Based on the fourth liquid level height value and the first conversion model, the fourth volume of the sample 30 to be tested inside the sample container 20 is obtained;

[0223] Among them, the fourth liquid level height value is the total liquid level height value of the sample 30 to be tested in the sample container 20;

[0224] The fourth volume is the total volume of the sample 30 to be tested inside the sample container 20.

[0225] In one implementation, controlling the sample container transfer device 300 to transfer the sample container 20 containing the sample to be tested 30 to the liquid level detection position includes: controlling the sample container transfer device 300 to transfer the sample container 20 containing the sample to be tested 30, after the sample to be tested 30 has been centrifuged into upper liquid 31, middle liquid 32 and lower liquid 33, to the liquid level detection position, wherein the lower liquid 33 contains red blood cells;

[0226] The control device 500 is also configured to perform the following steps of the detection process:

[0227] The liquid level of the sample container 20 located at the liquid level detection position is detected by the liquid level detection device, and the fifth liquid level height value of the lower liquid 33 in the sample container 20 is obtained.

[0228] Based on the fifth liquid level height value and the first conversion model, the fifth volume of the lower liquid 33 in the sample container 20 is obtained;

[0229] Based on the fourth and fifth volumes, the hematocrit of the test sample 30 was obtained.

[0230] Apart from the above, other parts and principles of the sample analysis device 10 provided in the third aspect of the present invention can be referred to the first and second aspects above, and will not be described in detail here.

[0231] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A control method for a sample analysis device, characterized in that: The conversion model calibration process includes the following steps: controlling a sample container transport device to transport a first sample container containing a first volume of reference liquid to a liquid level detection position; controlling a liquid level detection device to perform liquid level detection on the first sample container located at the liquid level detection position to obtain a first liquid level height value of the reference liquid in the first sample container; controlling the sample container transport device to transport a second sample container containing a second volume of reference liquid to the liquid level detection position; controlling a liquid level detection device to perform liquid level detection on the second sample container located at the liquid level detection position to obtain a second liquid level height value of the reference liquid in the second sample container; and obtaining a first conversion model characterizing the relationship between the volume and liquid level height of the liquid in a first type of sample container based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value; wherein the first volume is greater than or less than the second volume; the first sample container and the second sample container are two first type of sample containers; or, the first sample container and the second sample container are the same first type of sample container.

2. The control method for the sample analysis device as described in claim 1, characterized in that: The control liquid level detection device performs liquid level detection on the first sample container located at the liquid level detection position to obtain a first liquid level height value corresponding to the first volume, including: controlling a camera device to capture an image of the first sample container located at the liquid level detection position to obtain a first target image, and obtaining the first liquid level height value based on the first target image; the control liquid level detection device performs liquid level detection on the second sample container located at the liquid level detection position to obtain a second liquid level height value corresponding to the second volume, including: controlling the camera device to capture an image of the second sample container located at the liquid level detection position to obtain a second target image, and obtaining the second liquid level height value based on the second target image; preferably, the first target image at least includes an image showing the entire height of one side of the first sample container in a two-dimensional and / or three-dimensional form, and the second target image at least includes an image showing the entire height of one side of the first sample container in a two-dimensional and / or three-dimensional form. The first target image may contain an image showing the entire height of one side of the second sample container in a two-dimensional and / or three-dimensional form; or, the first target image may contain at least an image showing all the reference liquid in the first sample container in a two-dimensional and / or three-dimensional form, and the second target image may contain at least an image showing all the reference liquid in the second sample container in a two-dimensional and / or three-dimensional form; or, the first target image may contain at least an image showing the liquid surface of the reference liquid in the first sample container in a two-dimensional and / or three-dimensional form, and the second target image may contain at least an image showing the liquid surface of the reference liquid in the second sample container in a two-dimensional and / or three-dimensional form; or, the first target image may contain at least an image showing the bottom, middle, and top of the first sample container in a two-dimensional and / or three-dimensional form, and the second target image may contain at least an image showing the bottom, middle, and top of the second sample container in a two-dimensional and / or three-dimensional form.

3. The control method for the sample analysis device as described in claim 2, characterized in that: The control camera device captures images of the first sample container located at the liquid level detection position to obtain a first target image, and obtains the first liquid level height value based on the first target image, including: controlling the camera device to capture images of the first sample container located at the liquid level detection position at least twice to obtain at least two first target images, and obtaining the first liquid level height value based on the at least two first target images; the control camera device captures images of the second sample container located at the liquid level detection position to obtain a second target image, and obtains the second liquid level height value based on the second target image, including: controlling the camera device to capture images of the second sample container located at the liquid level detection position at least twice to obtain at least two second target images, and obtaining the second liquid level height value based on the at least two second target images.

4. The control method for the sample analysis device as described in claim 3, characterized in that: The step of obtaining the first liquid level height value based on the at least two first target images includes: obtaining at least two first initial height values ​​corresponding one-to-one with the at least two first target images, and averaging the at least two first initial height values ​​to obtain the first liquid level height value; the step of obtaining the second liquid level height value based on the at least two second target images includes: obtaining at least two second initial height values ​​corresponding one-to-one with the at least two second target images, and averaging the at least two second initial height values ​​to obtain the second liquid level height value; or, the step of obtaining the first liquid level height value based on the at least two first target images includes: obtaining three first initial height values ​​corresponding one-to-one with the three first target images, and taking one of the three first initial height values ​​other than the maximum and minimum values ​​as the first liquid level height value; the step of obtaining the first liquid level height value based on the at least two second target images includes: obtaining at least two first initial height values ​​corresponding one-to-one with the three first target images, and taking one of the three first initial height values ​​other than the maximum and minimum values ​​as the first liquid level height value; the step of obtaining the first liquid level height value based on the at least two second target images includes: obtaining at least two first initial height values ​​corresponding one-to-one with the three first target images, and averaging the at least two first initial height values ​​to obtain the first liquid level height value. The second liquid level height value includes: obtaining three second initial height values ​​corresponding one-to-one with the three second target images based on the three second target images, and taking one of the three second initial height values ​​other than the maximum and minimum values ​​as the second liquid level height value; or, obtaining the first liquid level height value based on the at least two first target images includes: obtaining at least four first initial height values ​​corresponding one-to-one with the at least four first target images based on the at least four first target images, and averaging the two first initial height values ​​other than the maximum and minimum values ​​among the at least four first initial height values ​​to obtain the first liquid level height value; obtaining the second liquid level height value based on the at least two second target images includes: obtaining at least four second initial height values ​​corresponding one-to-one with the at least four second target images based on the at least four second target images, and averaging the two second initial height values ​​other than the maximum and minimum values ​​among the at least four second initial height values ​​to obtain the second liquid level height value.

5. The control method for the sample analysis device as described in claim 4, characterized in that: Before obtaining the first conversion model characterizing the relationship between the volume and liquid level of the liquid in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes: obtaining a first range based on the maximum and minimum values ​​among all the first initial height values ​​obtained from at least two first target images; dividing the first range by the first liquid level value to obtain a first ratio; obtaining a second range based on the maximum and minimum values ​​among all the second initial height values ​​obtained from at least two second target images; dividing the second range by the second liquid level value to obtain a second ratio; if both the first ratio and the second ratio are less than or equal to a certain value... If the first ratio is equal to the first threshold, the first conversion model calibration of the first conversion model calibration process is determined to be successful. Based on the first volume, the first liquid level value, the second volume, and the second liquid level value, a first conversion model is obtained to characterize the relationship between the volume and liquid level of the liquid in the first type of sample container. If the first ratio or the second ratio is greater than the first threshold, the first conversion model calibration of the first conversion model calibration process is determined to be unsuccessful. Alternatively, before obtaining the first conversion model to characterize the relationship between the volume and liquid level of the liquid in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the control method further includes: [The text abruptly ends here, likely due to an incomplete sentence or missing information.] The maximum and minimum values ​​of all first initial height values ​​obtained from at least two first target images are compared one by one with the first liquid level height value; the maximum and minimum values ​​of all second initial height values ​​obtained from at least two second target images are compared one by one with the second liquid level height value; if the difference between the maximum value and the first liquid level height value, the difference between the first liquid level height value and the minimum value of all first initial height values, the difference between the maximum value and the second liquid level height value, and the difference between the second liquid level height value and the minimum value of all second initial height values ​​are all less than or equal to a second threshold, then the first conversion model calibration flow is determined to be... If the first conversion model calibration of the process is successful, a first conversion model is obtained based on the first volume, the first liquid level value, the second volume, and the second liquid level value to characterize the relationship between the volume of the liquid in the first type of sample container and the liquid level. If at least one of the differences between the maximum value and the first liquid level value among all the first initial height values, the differences between the first liquid level value and the minimum value among all the first initial height values, the differences between the maximum value and the second liquid level value among all the second initial height values, and the differences between the second liquid level value and the minimum value among all the second initial height values ​​is greater than the second threshold, then the first conversion model calibration of the first conversion model calibration process is determined to have failed.

6. The control method for the sample analysis device as described in claim 1, characterized in that: Before obtaining the first conversion model characterizing the relationship between the volume and liquid level of the liquid in the first type of sample container based on the first volume, the first liquid level value, the second volume, and the second liquid level value, the calibration process of the first conversion model further includes: controlling the sample container transport device to transport the third sample container containing the reference liquid of the third volume to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the third sample container located at the liquid level detection position to obtain the third liquid level value corresponding to the third volume; the first conversion model is obtained based on the first volume, the first liquid level value, the second volume, and the second liquid level value. A first conversion model for characterizing the relationship between the volume of liquid and the liquid level in the first type of sample container is obtained, comprising: obtaining the first conversion model based on the first volume, the first liquid level value, the second volume, the second liquid level value, the third volume, and the third liquid level value; wherein the third volume is greater than or less than the first volume, and the third volume is greater than or less than the second volume; the third sample container, the first sample container, and the second sample container are three first type of sample containers; or, the third sample container and at least one of the first sample container and the second sample container are the same first type of sample container.

7. The control method for the sample analysis device as described in claim 1, characterized in that: The control liquid level detection device performs liquid level detection on the first sample container located at the liquid level detection position to obtain a first liquid level height value corresponding to the first volume, including: controlling the liquid level detection device integrated on the pipette to perform liquid level detection on the first sample container located at the liquid level detection position to obtain the first liquid level height value; the control liquid level detection device performs liquid level detection on the second sample container located at the liquid level detection position to obtain a second liquid level height value corresponding to the second volume, including: controlling the liquid level detection device integrated on the pipette to perform liquid level detection on the second sample container located at the liquid level detection position to obtain the second liquid level height value.

8. The control method for the sample analysis device as described in claim 1, characterized in that: Before the control sample container transfer device transfers the first sample container containing the first volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the first volume based on information input by the operator through the display screen; before the control sample container transfer device transfers the second sample container containing the second volume of reference liquid to the liquid level detection position, the control method further includes: obtaining the second volume based on information input by the operator through the display screen.

9. The control method for the sample analysis device as described in any one of claims 1 to 8, characterized in that: Before the control sample container transfer device transfers the first sample container containing the first volume of reference liquid to the liquid level detection position, the control method further includes: controlling the display screen to display at least one of the following: information indicating that the operator should place the first sample container and the second sample container into the target position of the sample analysis device; information indicating that the operator should input the first volume and the second volume on the display screen.

10. The control method for the sample analysis device according to any one of claims 1 to 8, characterized in that: The control method further includes: controlling the execution of the first conversion model calibration process when any of the following first preset conditions are met: obtaining information for executing the first conversion model calibration process according to the instructions input by the operator through the human-computer interaction device; obtaining information for characterizing the change or addition of sample container type; obtaining information on the position change of the liquid level detection position and / or the liquid level detection device; obtaining information on the failure of the first conversion model calibration process; reaching a preset time point of a preset cycle; the cumulative running time of the liquid level detection device since the last execution of the first conversion model calibration process reaches a preset time; the cumulative number of liquid level detections performed by the liquid level detection device since the last execution of the first conversion model calibration process reaches a preset number; wherein, the human-computer interaction device includes at least one of a display screen, a voice interaction component, a button, a knob, and a push button.

11. The control method for the sample analysis device according to any one of claims 1 to 8, characterized in that: The control method further includes: controlling the display screen to show the conversion model calibration function option on the function interface; and executing the steps of the conversion model calibration process when the conversion model calibration function option is triggered.

12. The control method for the sample analysis device according to any one of claims 1 to 8, characterized in that: The first volume is half or twice the second volume; and / or the reference solution is one of mixed plasma, quality control material, calibrator, purified water, deionized water, and diluent.

13. The control method for the sample analysis device according to any one of claims 1 to 8, characterized in that: The control method further includes the following detection process steps: controlling the sample container transmission device to transmit the fourth sample container loaded with the first sample to be tested to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the fourth sample container located at the liquid level detection position to obtain the fourth liquid level height value of the first sample to be tested in the fourth sample container; obtaining the fourth volume of the first sample to be tested in the fourth sample container according to the fourth liquid level height value and the first conversion model; wherein, the fourth liquid level height value is the total liquid level height value of the first sample to be tested in the fourth sample container; the fourth volume is the total volume of the first sample to be tested in the fourth sample container; the fourth sample container and the first sample container are two sample containers of the first type.

14. The control method for the sample analysis device as described in claim 13, characterized in that: The step of controlling the sample container transfer device to transfer the fourth sample container containing the first test sample to the liquid level detection position includes: controlling the sample container transfer device to transfer the fourth sample container containing the first test sample, after the first test sample has been centrifuged into an upper liquid layer, a middle liquid layer, and a lower liquid layer, to the liquid level detection position, wherein the lower liquid layer contains red blood cells; the detection process further includes: performing liquid level detection on the fourth sample container located at the liquid level detection position according to the liquid level detection device to obtain a fifth liquid level height value of the lower liquid layer in the fourth sample container; obtaining a fifth volume of the lower liquid layer in the fourth sample container according to the fifth liquid level height value and the first conversion model; and obtaining the red blood cell volume of the first test sample according to the fourth volume and the fifth volume.

15. The control method for the sample analysis device as described in claim 14, characterized in that: The control method further includes: controlling the display screen to display the total volume and / or hematocrit of the first sample to be tested in the fourth sample container; and / or, controlling the liquid level detection device to perform liquid level detection on the fourth sample container located at the liquid level detection position to obtain the fourth liquid level height value and the fifth liquid level height value, including: controlling the camera device to take a picture of the fourth sample container located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image; the control method further includes: controlling the display screen to display the third target image; wherein the third target image at least includes an image showing the entire height of one side of the fourth sample container in a two-dimensional and / or three-dimensional form, or at least includes an image showing all the first samples to be tested in the fourth sample container in a two-dimensional and / or three-dimensional form, or at least includes images of the upper liquid level, the middle liquid level and the lower liquid level in the fourth sample container, or at least includes images showing the bottom, middle part and top of the fourth sample container in a two-dimensional and / or three-dimensional form.

16. The control method for the sample analysis device as described in claim 14, characterized in that: The control method further includes the following steps in the conversion model calibration process: controlling the sample container transport device to transport a fifth sample container containing a sixth volume of reference liquid to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the fifth sample container located at the liquid level detection position to obtain a sixth liquid level height value of the reference liquid in the fifth sample container; controlling the sample container transport device to transport a sixth sample container containing a seventh volume of reference liquid to the liquid level detection position, wherein the sixth volume is greater than or less than the seventh volume; controlling the liquid level detection device to perform liquid level detection on the fifth sample container located at the liquid level detection position. The sixth sample container is subjected to liquid level detection to obtain a seventh liquid level height value of the reference liquid in the sixth sample container; based on the sixth volume, the sixth liquid level height value, the seventh volume, and the seventh liquid level height value, a second conversion model is obtained to characterize the relationship between the volume and liquid level height of the liquid in the second type of sample container; the control method further includes the following detection process steps: controlling the sample container transfer device to transfer the seventh sample container loaded with the second test sample, after the second test sample has been centrifuged and separated into upper liquid, middle liquid, and lower liquid, to the liquid level detection position. The lower liquid contains red blood cells; the liquid level detection device is controlled to perform liquid level detection on the seventh sample container located at the liquid level detection position to obtain the eighth liquid level height value of the second sample to be tested in the seventh sample container and the ninth liquid level height value of the lower liquid in the seventh sample container; based on the eighth liquid level height value and the second conversion model, the eighth volume of the second sample to be tested in the seventh sample container is obtained; based on the ninth liquid level height value and the second conversion model, the ninth volume of the lower liquid in the seventh sample container is obtained; based on the eighth volume and the ninth volume, the red blood cell volume of the second sample to be tested is obtained; wherein, the eighth liquid level height value is the total liquid level height value of the second sample to be tested in the seventh sample container; the eighth volume is the total volume of the second sample to be tested in the seventh sample container; the fifth sample container, the sixth sample container, and the seventh sample container are three second-type sample containers, or the fifth sample container and the sixth sample container are the same second-type sample container, and the seventh sample container is another second-type sample container; the first-type sample container and the second-type sample container differ in at least one of the following: shape, size.

17. The control method for the sample analysis device as described in claim 16, characterized in that: The control of the sample container transport device to transport a first sample container containing a first volume of reference liquid to the liquid level detection position includes: controlling the sample container transport device to transport the first sample container from the first storage area of ​​the sample management device to the liquid level detection position; controlling the sample container transport device to transport a second sample container containing a second volume of reference liquid to the liquid level detection position includes: controlling the sample container transport device to transport the second sample container from the first storage area to the liquid level detection position; controlling the sample container transport device to transport a fourth sample container containing a first sample to be tested to the liquid level detection position includes: controlling the sample container transport device to transport the first sample container containing a first sample to be tested to the liquid level detection position. The device transfers the fourth sample container from the first storage area to the liquid level detection position; controlling the sample container transfer device to transfer the fifth sample container containing a sixth volume of reference liquid to the liquid level detection position includes: controlling the sample container transfer device to transfer the fifth sample container from the second storage area of ​​the sample management device to the liquid level detection position; controlling the sample container transfer device to transfer the sixth sample container containing a seventh volume of reference liquid to the liquid level detection position includes: controlling the sample container transfer device to transfer the sixth sample container from the second storage area to the liquid level detection position; controlling the sample container transfer device to transfer a second sample to be tested... The transfer of the seventh sample container to the liquid level detection position includes: controlling the sample container transfer device to transfer the seventh sample container from the second storage area to the liquid level detection position; wherein the first storage area and the second storage area are located in two different areas of the sample management device, and the first storage area is used for placing the first type of sample container to realize the loading of the first type of sample container, and the second storage area is used for placing the second type of sample container to realize the loading of the second type of sample container; or, obtaining the volume of liquid in the first type of sample container based on the first volume, the first liquid level height value, the second volume, and the second liquid level height value. Before the first conversion model relating to the liquid level height, the control method further includes: obtaining information that the first sample container belongs to the first type of sample container based on feedback information from the identification device's identification of the first sample container; obtaining information that the second sample container belongs to the first type of sample container based on feedback information from the identification device's identification of the second sample container; before obtaining the fourth volume of the first sample to be tested in the fourth sample container based on the fourth liquid level height value and the first conversion model, the control method further includes: obtaining information that the fourth sample container belongs to the first type of sample container based on feedback information from the identification device's identification of the fourth sample container;Before obtaining the second conversion model characterizing the relationship between the volume and liquid level of the liquid in the second type of sample container based on the sixth volume, the sixth liquid level value, the seventh volume, and the seventh liquid level value, the control method further includes: obtaining information that the fifth sample container belongs to the second type of sample container based on feedback information from the identification device's identification of the fifth sample container; obtaining information that the sixth sample container belongs to the second type of sample container based on feedback information from the identification device's identification of the sixth sample container; before obtaining the eighth volume of the second sample to be tested in the seventh sample container based on the eighth liquid level value and the second conversion model, the control method further includes: obtaining information that the seventh sample container belongs to the second type of sample container based on feedback information from the identification device's identification of the seventh sample container.

18. A control method for a sample analysis device, characterized in that: The detection process includes the following steps: controlling a sample container transport device to transport a sample container containing a first sample to be tested to a liquid level detection position; controlling a liquid level detection device to perform liquid level detection on the sample container located at the liquid level detection position to obtain a fourth liquid level height value of the first sample to be tested in the sample container; obtaining a fourth volume of the first sample to be tested in the sample container based on the fourth liquid level height value and a first conversion model; wherein, the first conversion model is used to characterize the relationship between the volume of liquid in the sample container and the liquid level height; the fourth liquid level height value is the total liquid level height value of the first sample to be tested in the sample container; and the fourth volume is the total volume of the first sample to be tested in the sample container.

19. The control method for the sample analysis device as described in claim 18, characterized in that: The step of controlling the sample container transfer device to transfer the sample container containing the first test sample to the liquid level detection position includes: controlling the sample container transfer device to transfer the sample container containing the first test sample, after the first test sample has been centrifuged into upper liquid, middle liquid, and lower liquid, to the liquid level detection position, wherein the lower liquid contains red blood cells; the detection process further includes: performing liquid level detection on the sample container located at the liquid level detection position according to the liquid level detection device to obtain a fifth liquid level height value of the lower liquid in the sample container; and based on the fifth liquid level height value and the first transfer... The model is changed to obtain the fifth volume of the lower liquid in the sample container; the hematocrit of the first sample to be tested is obtained based on the fourth volume and the fifth volume; and / or, the liquid level detection device is controlled to perform liquid level detection on the sample container located at the liquid level detection position to obtain the fourth liquid level height value of the first sample to be tested in the sample container and the fifth liquid level height value of the lower liquid in the sample container, including: controlling the camera device to take a picture of the sample container located at the liquid level detection position to obtain a third target image, and obtaining the fourth liquid level height value and the fifth liquid level height value based on the third target image.

20. A sample analysis device, characterized in that: include: A sample measuring device, the sample measuring device being used to: draw at least a portion of the sample to be tested from a sample container containing the sample to be tested and dispense it into a reaction container, and to measure the test solution in the reaction container which is at least composed of the sample to be tested and a reagent; and a sample container transport device, the sample container transport device being used to transport the sample container. A liquid level detection device, wherein the liquid level detection device is used to detect the liquid level of the sample container that has been transferred to the liquid level detection position by the sample container transfer device; The display screen is used to display at least a functional interface; the control device is configured to: control the display screen to display the conversion model calibration function option on the functional interface, and when the conversion model calibration function option is triggered, execute the steps of the conversion model calibration process to obtain a conversion model for characterizing the relationship between the volume of liquid and the liquid level in the sample container.

21. The sample analysis device as described in claim 20, characterized in that: The control device is further configured to perform the following detection process steps: controlling the sample container transfer device to transfer the sample container containing the sample to be tested to the liquid level detection position; controlling the liquid level detection device to perform liquid level detection on the sample container located at the liquid level detection position to obtain a fourth liquid level height value of the sample to be tested in the sample container; obtaining a fourth volume of the sample to be tested in the sample container based on the fourth liquid level height value and the first conversion model; wherein, the fourth liquid level height value is the total liquid level height value of the sample to be tested in the sample container; the fourth volume is the total volume of the sample to be tested in the sample container; preferably, controlling the sample container transfer device to transfer the sample container containing the sample to the liquid level detection position to the liquid level detection position to obtain a fourth liquid level height value of the sample container containing the sample container; wherein, controlling the sample container transfer device to transfer the sample container containing the sample to be tested ... container to the liquid level The liquid level detection station includes: controlling the sample container transfer device to transfer a sample container loaded with a sample to be tested, after the sample to be tested has been centrifuged and separated into an upper liquid layer, a middle liquid layer, and a lower liquid layer, to the liquid level detection station, wherein the lower liquid layer contains red blood cells; the control device is further configured to perform the following steps of the detection process: performing liquid level detection on the sample container located at the liquid level detection station according to the liquid level detection device to obtain a fifth liquid level height value of the lower liquid layer in the sample container; obtaining a fifth volume of the lower liquid layer in the sample container according to the fifth liquid level height value and the first conversion model; and obtaining the red blood cell volume of the sample to be tested according to the fourth volume and the fifth volume.

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