Disease prediction method and system based on human immune age

By constructing an immune age prediction model based on multiple linear regression and binary logistic regression, immune biomarkers that are significantly related to age are screened out. This solves the problem of insufficient accuracy and interpretability in the existing immune age assessment, and realizes low-cost, accurate probability prediction of respiratory disease risk, supporting personalized intervention in health management.

CN121964121APending Publication Date: 2026-05-01中国人民解放军总医院第八医学中心 +1
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Patent Information

Application Number
CN202511629552.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-07
Publication Date
2026-05-01

AI Technical Summary

Technical Problem

Existing technologies lack an immune age assessment scheme that combines good accuracy, strong interpretability, and clinical applicability, especially for low-cost probability prediction of specific disease risks, making it difficult to apply effectively in health management and early intervention.

Method used

An immune age prediction model based on multiple linear regression and binary logistic regression was constructed. By screening immune biomarkers that are significantly related to age, such as red blood cell count, TNF-α, absolute CD8+ T cell count and absolute CD4+ T cell count, a risk prediction model for respiratory diseases was established, and risk assessment was carried out in combination with actual age group.

Benefits of technology

This represents a leap from traditional qualitative assessment to precise probabilistic prediction, providing a low-cost basis for risk stratification and personalized intervention in health management, and improving the accuracy and interpretability of disease risk prediction.

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Abstract

The invention discloses a disease prediction method and system based on human immune age. According to the method, a specific immune marker in blood of a subject is detected, the immune age of the subject is calculated by using a multiple linear regression model, and further based on the immune age, a quantitative probability risk value of the respiratory system disease of an individual is generated by adopting age group binary logistic regression analysis, so that early-stage and probabilistic early warning of the disease risk is realized. The invention further provides a model for quantitatively associating the immune age with the lung function, and the model can be used for comprehensive risk assessment of specific diseases such as chronic obstructive pulmonary diseases. The method has the advantages of model robustness, high interpretability and low cost, and is suitable for health screening, risk stratification and personalized medical intervention.
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