Elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and preparation method thereof

Abstract

The invention relates to an elsholtzia and ginseng composite peptide special diet for improving cardiovascular and cerebrovascular diseases and microcirculation disturbance and a preparation method thereof. The special diet comprises the following components: 5-15% of small molecule peptide; 18-65% of a plant extract; 0.1 to 3 percent of gamma-aminobutyric acid; 0.01 to 1 percent of N-acetylneuraminic acid; 0.005% to 0.1% of thiamine; 0.001 to 0.05 percent of riboflavin; and the balance of auxiliary materials. Wherein the plant extract comprises at least one of elsholtzia, rhizoma zingiberis and ginseng. According to the scheme provided by the invention, the elasticity and permeability of blood capillaries can be improved, microcirculation can be improved, blood fat can be reduced, and cardiovascular and cerebrovascular diseases can be effectively prevented and relieved.

Description

Technical Field

[0001] This application relates to the field of health food technology, and in particular to a special dietary supplement containing ginseng and sesame compound peptides that improves cardiovascular and cerebrovascular diseases and microcirculation disorders, and its preparation method. Background Technology

[0002] Cardiovascular and cerebrovascular diseases are a collective term for diseases of the heart and brain blood vessels. They are ischemic or hemorrhagic diseases of the heart, brain, and other tissues caused by conditions such as hyperlipidemia, high blood viscosity, atherosclerosis, and hypertension. Cardiovascular and cerebrovascular diseases are common diseases that seriously threaten human health, especially for middle-aged and elderly people over 50 years of age, and are characterized by high morbidity, high disability rate, and high mortality rate.

[0003] Cardiovascular and cerebrovascular diseases are manifestations of systemic vascular diseases in the heart and brain. Their causes mainly fall into four categories: ① vascular factors such as atherosclerosis, hypertensive arteriosclerosis, and arteritis; ② hemodynamic factors such as hypertension; ③ hemorheological abnormalities such as hyperlipidemia and diabetes; and ④ blood component factors such as leukemia, anemia, and thrombocytosis. Long-term unhealthy lifestyle habits are a significant factor in the occurrence and development of cardiovascular and cerebrovascular diseases, directly affecting their recovery and prognosis. For example, smoking, excessive alcohol consumption, excessive dietary fat intake, and lack of necessary exercise can lead to damage to blood vessel tissues and increased blood viscosity, resulting in vascular obstruction or rupture, thrombosis, and other phenomena, triggering myocardial infarction or cerebral infarction.

[0004] Besides medication and surgical interventions, early prevention and preventative care for cardiovascular and cerebrovascular diseases are also crucial for improving their condition. For example, controlling blood pressure and blood lipids to appropriate deionization levels through a balanced diet, reducing the intake of high-salt and high-fat foods, and increasing physical activity can promote blood circulation and lower the probability of disease occurrence. Furthermore, nutritional supplements that can help lower blood lipids and improve cardiovascular microcirculation can be developed to accelerate the improvement of cardiovascular and cerebrovascular health. Summary of the Invention

[0005] To address or partially address the problems existing in related technologies, this application provides a special dietary supplement containing ginseng and euphorbia humifusa compound peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders, as well as its preparation method. This supplement can increase the elasticity and permeability of capillaries, improve microcirculation, reduce blood lipids, and effectively prevent and alleviate cardiovascular and cerebrovascular diseases.

[0006] The first aspect of this application provides a special dietary supplement containing *Elsholtzia ciliata* and ginseng compound peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders, comprising the following components: 5-15% small molecule peptides; 18-65% plant extracts; 0.1-3% γ-aminobutyric acid; 0.01-1% N-acetylneuraminic acid; 0.005-0.1% thiamine; 0.001-0.05% riboflavin; and the remainder being excipients.

[0007] The plant extract contains at least one of Elsholtzia ciliata, dried ginger, and ginseng.

[0008] In some embodiments, the small molecule peptides include earthworm protein powder.

[0009] In some embodiments, the small molecule peptides further include at least one of wheat oligopeptides and collagen peptides; and the mass ratio of earthworm protein powder, wheat oligopeptides, and collagen peptides is (1.5-3):1:1.

[0010] In some embodiments, the mass ratio of Elsholtzia ciliata, dried ginger, and ginseng in the plant extract is 1:1:1.

[0011] In some embodiments, the plant extract further includes at least one of the following: coix seed, honeysuckle, cinnamon, licorice, angelica, almond, and schizonepeta.

[0012] In some embodiments, the mass ratio of the small molecule peptide to the plant extract is 1:(3.5 to 4.5).

[0013] In some embodiments, 0.1-5% DHA algal oil is also included.

[0014] In some embodiments, the preparation steps of the plant extract include:

[0015] A1. Take plant raw materials, soak them in drinking water for 2-3 hours, heat to boiling, boil for 1-2.5 hours, and then filter to obtain the first plant extract;

[0016] A2. Add drinking water to the filter residue and heat to boiling. After boiling for 1 to 2.5 hours, filter to obtain the second plant extract. Repeat the boiling step 0 to 3 times to obtain the mixed plant pulp.

[0017] A3. The plant pulp was concentrated at 60–85°C to obtain a concentrated plant extract.

[0018] In some embodiments, the density of the plant extract concentrate is 1.0 to 1.5.

[0019] The second aspect of this application provides a method for preparing a special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders. The specific steps are as follows:

[0020] S1. First, dissolve the plant extract in purified water and mix thoroughly to obtain a mixed solution;

[0021] S2. Add small molecule peptides, γ-aminobutyric acid, N-acetylneuraminic acid, thiamine, riboflavin and excipients, mix evenly, filter, sterilize and fill to obtain a special dietary supplement of ginseng and sesame compound peptides that improves cardiovascular and cerebrovascular diseases and microcirculation disorders.

[0022] The technical solution provided in this application may include the following beneficial effects:

[0023] The special dietary supplement containing *Elsholtzia ciliata* and ginseng compound peptides proposed in this application for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders contains small molecule peptides, plant extracts, and a combination of γ-aminobutyric acid, N-acetylneuraminic acid, thiamine, and riboflavin. This combination is easily absorbed by the human body and can act rapidly on human tissues. Through the synergistic effect of its components, it can not only rapidly increase the elasticity and permeability of capillaries, improve blood circulation, and ensure the normal exchange of substances inside and outside blood vessels, thus preventing damage to blood vessels caused by blood pressure fluctuations or the accumulation of metabolic products, effectively preventing and reducing the risk of high blood pressure; it can also inhibit platelet aggregation and reduce inflammatory responses, effectively preventing and alleviating cardiovascular and cerebrovascular diseases.

[0024] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Detailed Implementation

[0025] It should be understood that although the terms "first," "second," "third," etc., may be used in this application to describe various information, this information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0026] The special dietary supplement containing ginseng and sesame compound peptides provided in this application for improving cardiovascular and cerebrovascular diseases and microcirculation disorders includes the following components: 5-15% small molecule peptides; 18-65% plant extracts; 0.1-3% γ-aminobutyric acid; 0.01-1% N-acetylneuraminic acid; 0.005-0.1% thiamine; 0.001-0.05% riboflavin; and the remainder being excipients.

[0027] The small molecule peptides may include earthworm protein powder. Earthworm protein powder is extracted from earthworms and contains various components such as collagenase, plasminase, lumbrokinase, nucleic acid, and trace elements. Its molecular weight is between 50 and 1000 Da, belonging to short-chain small molecules. In the embodiments of this application, the selected earthworm protein powder has a molecular weight of 300 to 600 Da.

[0028] Earthworm protein is typically used for its anti-thrombotic and vascular circulation-improving effects. Because it can readily enter microvessels to dissolve blood clots, it restores elasticity to hardened microvessels, alleviating blockages and distortions. Furthermore, earthworm protein has a potent, direct thrombolytic effect, dissolving both fresh and old blood clots. It also enhances the body's own anticoagulant capacity and activates the differentiation properties of vascular endothelial cells, generating new blood vessels to alleviate and repair necrotic brain nerve cells.

[0029] Earthworm protein has the following specific functions:

[0030] 1. Regulating blood pressure: Earthworm protein helps reduce peripheral blood flow resistance by restoring vascular elasticity and improving microcirculation, thereby lowering blood pressure. For patients with primary hypertension, taking earthworm protein can help control blood pressure at or near-normal levels.

[0031] 2. Antithrombotic effect: The active ingredient of earthworm protein can produce plasmin, which can inhibit platelet aggregation, anticoagulate, and reduce blood viscosity, thereby effectively preventing thrombus formation.

[0032] 3. Improve physical discomfort symptoms: Earthworm protein also has antipyretic, sedative, cough-relieving, and urination-promoting effects. It can be used to improve symptoms such as high fever and convulsions caused by various diseases, relieve discomfort caused by bronchial smooth muscle spasms, and assist in the treatment of bronchitis, cough-variant asthma, and other diseases.

[0033] The small molecule peptides may also include at least one of wheat oligopeptides and collagen peptides; the small molecule peptides are preferably a composite peptide composed of earthworm protein powder, wheat oligopeptides and collagen peptides.

[0034] Wheat oligopeptides are small molecule polypeptides obtained from wheat-extracted proteins using various enzyme preparations through targeted enzymatic hydrolysis and specific small peptide separation techniques. Wheat oligopeptides have good water solubility, are easily absorbed, and possess strong biological activity, exhibiting excellent health benefits. They provide the human body with various essential amino acids, aiding in the repair of human tissue cells. They can supplement protein nutrition, increase muscle strength, and restore physical energy. The molecular weight of wheat oligopeptides is approximately 50–1000 Da. In the embodiments of this application, the preferred molecular weight of the selected wheat oligopeptides is 200–500 Da.

[0035] Wheat oligopeptides have effects such as inhibiting cholesterol rise, promoting insulin secretion, and inhibiting angiotensin-converting enzyme. Specifically, they include:

[0036] 1. Inhibits cholesterol rise: Wheat oligopeptides are polypeptide substances obtained from proteins extracted from wheat protein powder and then separated using separation technology, which can increase cholesterol levels.

[0037] 2. Promotes insulin secretion: Wheat oligopeptides contain oligomethionine, which can enhance the body's insulin secretion, help regulate blood sugar, and improve diabetes-related symptoms.

[0038] 3. Inhibition of angiotensin-converting enzyme: Wheat oligopeptides can dilate blood vessels and thus lower blood pressure by inhibiting the production of angiotensin-converting enzyme.

[0039] Collagen peptides are products of collagen hydrolysis, substances that lie between amino acids and large protein molecules. They are rich in essential amino acids such as glycine, proline, and hydroxyproline. They are more easily digested and absorbed, provide rapid energy to the body, do not denature proteins, have low allergenicity, and good water solubility, and possess multiple bioactive functions. Specifically, these include:

[0040] 1. Helps promote bone development: Collagen peptides can promote bone development, increase the toughness of bone tissue, and help prevent fractures and osteoporosis.

[0041] 2. Helps enhance joint mobility: Collagen peptides can enhance joint mobility and flexibility, and can help prevent arthritis and synovitis.

[0042] 3. Helps improve skin condition: Collagen peptides can improve skin elasticity, making the skin more supple, and can help prevent skin aging, improve wrinkles and sagging skin.

[0043] 4. Helps improve blood circulation: Collagen peptides can improve blood circulation and increase blood volume, which can help prevent diseases such as heart disease and high blood pressure.

[0044] For cardiovascular and cerebrovascular diseases, collagen peptides can increase the number and activity of endothelial progenitor cells, thereby promoting endothelial cell proliferation and migration, and repairing damaged blood vessel walls. In addition, it also has anti-inflammatory effects, reducing the damage of inflammatory responses to the cardiovascular system. Therefore, it can significantly improve symptoms of cardiovascular and cerebrovascular diseases, such as chest pain, shortness of breath, dizziness, headache, hemiplegia, and aphasia.

[0045] In this embodiment, the selected collagen peptide can be bovine collagen peptide, preferably with a molecular weight of 500-800 Da. Its preparation method mainly includes:

[0046] (1) Raw material pretreatment: Remove impurities from fresh beef bones and crush them into 2-3 cm pieces using a bone crusher. After crushing, clean the beef bones and put them into a cooking tank with water added for cooking. The volume ratio of beef bones to water is 1:3, the cooking temperature is 100℃, the cooking pressure is 2MPa, and the cooking time is 4h to obtain the cooking liquid.

[0047] (2) Oil-water separation: The cooking liquid is separated into oil and water by gravity separation, and the resulting aqueous phase is cooled to 50-55℃ to obtain crude collagen solution.

[0048] (3) Enzymatic hydrolysis: 0.1% (w / w) of a high-efficiency compound enzyme preparation by weight of the raw material is added to the crude collagen solution. After mixing evenly, enzymatic hydrolysis is performed for 1 hour to obtain a collagen peptide solution. The high-efficiency compound enzyme preparation consists of the following components in the indicated mass percentages: 30% complex protease, 30% flavor protease, 30% alkaline protease, 7% animal protein hydrolase, and 3% enzyme activator. The enzyme activator consists of the reducing agent dithiothreitol, β-mercaptoethanol, and the divalent metal ion Mg. 2+ Zn 2+ Ca 2+ The composition includes a reducing agent in which the molar ratio of dithiothreitol to β-mercaptoethanol is 1:1, a reducing agent in which the molar ratio of divalent metal ions is 1:1, and Mg... 2+ Zn 2+ Ca 2+ The molar ratio is 1:1:1.

[0049] (4) Ceramic membrane filtration: The collagen peptide solution is filtered using an inorganic nanofiltration ceramic membrane with a molecular weight cutoff of 800 Da, and the resulting permeate is a high-purity collagen peptide solution.

[0050] (5) High temperature and high pressure treatment: The high purity collagen peptide solution was treated at a temperature of 130℃ and a pressure of 0.1MPa for 5 minutes to obtain the treatment solution.

[0051] (6) Concentration: The treatment liquid is concentrated by heating under reduced pressure to obtain concentrated liquid.

[0052] (7) Drying and powdering and packaging: The concentrate is spray-dried into powder and packaged to obtain bovine bone collagen peptide product.

[0053] In the embodiments of this application, the mass ratio of earthworm protein powder, wheat oligopeptide, and bone collagen peptide is (1.5-3):1:1; preferably 2:1:1.

[0054] In this embodiment of the application, the plant extract includes at least one of Elsholtzia ciliata, dried ginger, and ginseng.

[0055] Among them, *Elsholtzia ciliata*, also known as perilla or large elm, is a common herb with effects including: inducing sweating to relieve exterior syndromes, resolving dampness and harmonizing the middle jiao, and promoting diuresis and reducing swelling. Specifically,

[0056] 1. Elsholtzia ciliata has pungent and warm properties that promote sweating, thereby relieving wind-cold pathogens on the surface of the body. It has a good therapeutic effect on symptoms such as chills, fever, and lack of sweating caused by wind-cold common cold.

[0057] 2. Elsholtzia ciliata has the function of clearing away dampness and regulating the spleen and stomach. It has a certain curative effect on symptoms such as abdominal distension, vomiting and diarrhea caused by dampness obstructing the middle jiao. It is especially suitable for summer colds caused by dampness and heat, and is often used with other dampness-clearing and heat-relieving herbs such as agastache rugosa and eupatorium fortunei.

[0058] 3. Elsholtzia can promote lung qi circulation, regulate water metabolism, and facilitate the metabolism and excretion of body fluids, thus having a diuretic and swelling-reducing effect. It can be combined with other diuretic and dampness-removing herbs such as Poria cocos and Atractylodes macrocephala.

[0059] Dried ginger is the dried rhizome of the ginger plant (Zingiber officinale). It appears as flat, tuberous pieces with finger-like branches. The surface is grayish-yellow or light grayish-brown, rough, with longitudinal wrinkles and distinct segments. It is firm in texture, with a yellowish-white or grayish-white, powdery or granular cross-section. The endodermis rings are clearly visible, and vascular bundles and yellow oil dots are scattered throughout. It has a fragrant, distinctive odor and a pungent taste. It possesses the following medicinal properties and uses:

[0060] 1. Warming the Middle Jiao and Dispelling Cold: Dried ginger is hot in nature and pungent in taste. It mainly enters the spleen and stomach meridians and is good at warming the middle jiao and dispelling cold, making it an essential medicine for warming the middle jiao. It has significant effects on symptoms such as cold pain in the stomach, vomiting, and diarrhea caused by spleen and stomach deficiency and cold. It can be combined with spleen-tonifying and qi-boosting herbs such as Codonopsis pilosula and Atractylodes macrocephala to enhance the effect of warming the middle jiao and strengthening the spleen.

[0061] 2. Restore Yang and Unblock Meridians: Dried ginger has the effects of invigorating heart Yang and warming and unblocking the meridians. It can be used to treat Yang collapse syndrome caused by deficiency of heart and kidney Yang and excessive internal Yin-cold. Symptoms include cold extremities and a weak, almost imperceptible pulse. It is often combined with aconite to enhance its power to restore Yang and rescue from collapse.

[0062] 3. Warming the Lungs and Resolving Phlegm: Dried ginger can warm the lungs, dispel cold, resolve phlegm, and stop coughing. It has a good therapeutic effect on symptoms such as cough, wheezing, and copious clear phlegm caused by cold phlegm accumulating in the lungs. It is often combined with herbs such as Asarum and Schisandra to achieve the effects of warming the lungs, resolving phlegm, stopping cough, and relieving asthma.

[0063] Ginseng is the root of the ginseng plant, belonging to the Araliaceae family. The main root is spindle-shaped or cylindrical, with two or three branch roots at the lower part. Its surface is pale yellow, with obvious longitudinal wrinkles and fine root scars, while the upper part has sparse, shallow, discontinuous coarse transverse lines and obvious wart-like protrusions. The rhizome (root head) is short and thin, often constricted and curved, with adventitious roots and sparse, pitted stem scars (root bowls). Ginseng has the following medicinal properties:

[0064] 1. **Greatly Replenishes Vital Energy:** Ginseng can greatly replenish the body's vital energy, and has a significant therapeutic effect on cases of extreme deficiency and impending collapse of vital energy caused by serious illness, prolonged illness, or severe blood loss. Symptoms may include weak breathing, profuse sweating, and a faint pulse. It is often combined with herbs such as aconite to enhance its effects of restoring yang, rescuing from collapse, and greatly replenishing vital energy.

[0065] 2. Tonifying the Spleen and Lungs: Ginseng enters the spleen and lung meridians, tonifying spleen and lung qi. It has a good therapeutic effect on symptoms such as loss of appetite, fatigue, abdominal distension, and loose stools caused by spleen qi deficiency, as well as symptoms such as shortness of breath, wheezing, and spontaneous sweating caused by lung qi deficiency. It can be used in combination with spleen-tonifying herbs such as Atractylodes macrocephala and Poria cocos, or lung-tonifying herbs such as Astragalus membranaceus and Schisandra chinensis.

[0066] 3. Promotes the production of body fluids and quenches thirst: Ginseng has the effect of promoting the production of body fluids and quenching thirst. It can be used to treat syndromes of qi and body fluid deficiency caused by febrile diseases, manifested as thirst, excessive sweating, and fatigue. It is often combined with herbs such as Ophiopogon japonicus and Schisandra chinensis to enhance the effect of replenishing qi and promoting the production of body fluids.

[0067] 4. Calming the mind and improving intelligence: Ginseng can replenish heart qi, calm the mind and improve intelligence. It has a certain therapeutic effect on symptoms such as palpitations, insomnia, and forgetfulness caused by insufficient heart qi. It can be used in combination with calming herbs such as jujube seed and polygala root.

[0068] In this embodiment, Elsholtzia ciliata, dried ginger, and ginseng are used in combination. This combination promotes blood circulation, increases capillary elasticity and permeability, improves microcirculation, and effectively prevents and alleviates cardiovascular and cerebrovascular diseases.

[0069] In this embodiment, the mass ratio of Elsholtzia ciliata, dried ginger, and ginseng is 1:1:1.

[0070] In this embodiment, the plant extract also includes at least one of the following: coix seed, honeysuckle, cinnamon, licorice, angelica, apricot kernel, and schizonepeta; preferably, it is a combination of the above-mentioned Chinese medicinal materials.

[0071] Job's tears (Coix seed) is the dried, mature seed of the Gramineae plant (Coix lacryma-jobi). Its main active ingredients include coix polysaccharides, acidic polysaccharides, coixol, phenols, various unsaturated fatty acids, and various amino acids. Job's tears are cooling in nature and can clear heat and detoxify for patients with excessive liver fire. They can promote blood circulation and water metabolism, thus also clearing heat and promoting diuresis. Job's tears have a preventative effect on cardiovascular diseases because they can lower blood cholesterol and triglycerides, and prevent cardiovascular diseases such as hyperlipidemia, hypertension, and thrombosis. In addition, Job's tears are rich in water-soluble fiber, which can absorb bile salts responsible for fat digestion, reducing the absorption rate of fat in the intestines, lowering blood lipids, and also aiding in weight loss.

[0072] Honeysuckle contains various chemical components, including flavonoids, iridoids, triterpenes and triterpenoid saponins, organic acids, and volatile oils. Honeysuckle contains a compound called rutin, which can dilate blood vessels, lower blood pressure, and reduce the burden on the heart, thereby preventing cardiovascular diseases. Furthermore, honeysuckle is rich in flavonoids, which have antioxidant properties, scavenging free radicals, reducing oxidative damage, and protecting cardiovascular health. It can also lower blood lipids, reduce the accumulation of cholesterol and triglycerides, and alleviate vascular inflammation, thus preventing cardiovascular diseases such as atherosclerosis.

[0073] Cinnamon is considered a warming food in traditional Chinese medicine. It contains volatile oils, the main component of which is cinnamaldehyde, accounting for over 70%. It also contains volatile compounds such as cinnamyl acetate, coumarins, and benzaldehyde, as well as non-volatile components like polysaccharides, diterpenes, polyphenols, and flavonoids. Cinnamon is believed to enhance brain function, particularly improving memory and concentration, and may offer some benefits in preventing certain types of Alzheimer's disease. It can also improve blood supply to the heart, particularly by lowering blood lipids, thus improving the internal environment of the heart and brain blood vessels and offering some protection against cardiovascular and cerebrovascular diseases. Furthermore, cinnamon can promote metabolism, regulate blood sugar and blood lipids, and even indirectly regulate blood pressure, offering numerous health benefits.

[0074] Licorice is neutral in nature and sweet in taste, and it enters the heart, lung, spleen, and stomach meridians. Licorice contains various chemical components, including triterpenoids, flavonoids, polysaccharides, coumarins, alkaloids, volatile oils, and trace elements. Among these, glycyrrhizic acid and glycyrrhizin have antitussive and expectorant effects, and can be used to relieve respiratory symptoms such as cough and excessive phlegm. Glycyrrhetinic acid and glycyrrhizin have anti-inflammatory and antibacterial effects, and can be used to treat some inflammatory diseases. In addition, it also protects the gastric mucosa, relieves stomach discomfort, regulates the endocrine system, balances hormone levels, dilates blood vessels, lowers blood pressure, has anti-allergic effects, and protects the liver.

[0075] Angelica dahurica is pungent and warm in nature, and enters the lung, stomach, and large intestine meridians. It contains volatile oils, such as methylcyclodecane, 1-tetradecene, ethyl laurate, several furanocoumarins, imperatorin, angelicin, scopolamine, angelicin, isoimperatorin lactone, hydrated angelicin, isopyrrolidone, oxyimperatorin, anethole, carvacrol, palmitic acid, etc. The root of Angelica dahurica is used medicinally, possessing properties such as dispelling dampness and pathogens, promoting pus drainage and tissue regeneration, and relieving pain. It is mainly used to treat colds due to wind-cold, headaches, rhinitis, toothaches, leukorrhea, boils, and carbuncles. Angelica dahurica also has many other benefits, such as protecting the cardiovascular system, beautifying the skin, and invigorating the mind.

[0076] Almonds are rich in flavonoids and isoimperatorin, which can improve cardiovascular function, increase vascular permeability, and prevent vascular aging, thus offering some preventative benefits against hypertension and hyperlipidemia. Furthermore, angelica dahurica is rich in monounsaturated fatty acids, vitamin E, and antioxidants, which can enhance heart function, promote myocardial contraction, stabilize heart rate, and prevent heart disease; it also strengthens the immune system, improving the body's ability to fight disease. Angelica dahurica can promote skin metabolism, prevent pigment accumulation on the skin surface, prevent age spots, repair damaged skin cells, lighten age spots, and whiten the skin. In addition, angelica dahurica has a stimulating effect on the nervous system, activating the brain and providing a refreshing feeling.

[0077] Catnip is rich in chemical components, mainly including volatile oils (such as monoterpenes, sesquiterpenes, aldehydes, and ketones, like L-menthol, menthol, and caryophyllene), other terpenes, flavonoids (such as apigenin, kaempferol, and rutin), and other components (such as chlorogenic acid and β-sitosterol). Among these, the volatile oils can promote the activity of the renin-angiotensin-aldosterone system, thereby lowering blood pressure; affect platelet function, reducing adhesion and aggregation, and preventing thrombosis; dilate peripheral blood vessels, including coronary arteries, increasing blood supply to the heart; enhance local tissue blood circulation, increase blood flow, help reduce blood viscosity, and prevent cardiovascular diseases.

[0078] This application's embodiments utilize a combination of herbs including Elsholtzia ciliata, dried ginger, ginseng, coix seed, honeysuckle, cinnamon, licorice root, angelica dahurica, apricot kernel, and schizonepeta tenuifolia. This combination effectively lowers blood cholesterol and triglycerides, increases vascular permeability, enhances blood circulation, reduces blood viscosity, and prevents cardiovascular diseases such as hyperlipidemia, hypertension, and thrombosis. Furthermore, the combination of these Chinese medicinal herbs can harmonize each other, mitigating the toxicity and potency of the drugs, allowing each herb to work synergistically and significantly enhancing its efficacy in improving cardiovascular and cerebrovascular diseases.

[0079] In this embodiment, the mass ratio of Elsholtzia ciliata, dried ginger, ginseng, coix seed, honeysuckle, cinnamon, licorice, angelica dahurica, apricot kernel, and schizonepeta tenuifolia is 1:1:1:1:1:1:1:1:1:1:1.

[0080] In this embodiment of the application, the preparation steps of the plant extract include:

[0081] A1. Take plant raw materials, soak them in drinking water for 2-3 hours, heat to boiling, boil for 1-2.5 hours, and then filter to obtain the first plant extract;

[0082] A2. Add drinking water to the filter residue and heat to boiling. After boiling for 1 to 2.5 hours, filter to obtain the second plant extract. Repeat the boiling step 0 to 3 times and mix the plant extracts to obtain the mixed plant pulp.

[0083] A3. The plant pulp was concentrated at 60–85°C to obtain a concentrated plant extract.

[0084] In step A1, the amount of drinking water added is 10 times the amount of plant raw materials; after soaking, the plant raw materials can be crushed, pressed and then heated, or the plant raw materials can be crushed and then soaked.

[0085] In step A2, the amount of drinking water added is 8 times the amount of plant material.

[0086] The density of the plant extract concentrate in step A3 is 1.0 to 1.5; preferably 1.2 to 1.3.

[0087] In the embodiments of this application, the mass ratio of small molecule peptides to plant extracts is 1:(3.5 to 4.5).

[0088] In the embodiments of this application, the mass ratio of γ-aminobutyric acid and N-acetylneuraminic acid is (1.5~2.5):1.

[0089] Among them, γ-aminobutyric acid (GABA), as an inhibitory neurotransmitter, has a brain-awakening effect. It can improve cerebral blood flow, increase oxygen supply, and promote brain metabolism. It can be used to treat headaches, tinnitus, and altered consciousness caused by stroke, head trauma sequelae, and cerebral arteriosclerosis sequelae, and also has a certain effect on improving liver and kidney function. It can also lower blood pressure, promote cerebral blood flow, increase oxygen supply, and promote brain metabolism.

[0090] In addition, gamma-aminobutyric acid (GABA) acts on the cerebrovascular center, lowering blood pressure and inhibiting the secretion of antidiuretic hormone, thus dilating blood vessels and reducing blood pressure. It can also treat epilepsy because it is an inhibitory amino acid that counteracts the excitatory effect of glutamate, thereby treating epilepsy. It can also improve lipid metabolism, prevent arteriosclerosis, and has a sobering effect by promoting the excretion of alcohol metabolites. It can prevent skin aging, eliminate body odor, and enhance flavor, possessing a glutamate-like sweetness that can improve the taste of food.

[0091] N-acetylneuraminic acid, also known as sialic acid, is a naturally occurring amino acid derivative and a salivary enzyme. It is widely present in the human body, especially abundant in the brain and nerve tissue. N-acetylneuraminic acid mainly has the following functions:

[0092] 1. Promotes brain development and enhances brain function

[0093] N-acetylneuraminic acid (N-acetylneuraminic acid) is an important component of neurotransmitters in the brain, promoting synapse growth and aiding in brain cell growth, development, and repair. For infants and adolescents, sufficient N-acetylneuraminic acid contributes to intellectual development and improved academic performance. For adults, it can also help enhance mental agility and memory.

[0094] 2. Provides energy for brain cells

[0095] N-acetylneuraminic acid can provide energy and substrates to meet the needs of brain cells. It can be converted into metabolites such as aspartic acid and acetyl-CoA to provide energy for brain cells.

[0096] 3. Improve sleep quality

[0097] N-acetylneuraminic acid can also regulate neurotransmitters, participate in neurotransmitter metabolism, relieve tension, and improve sleep quality.

[0098] 4. Protect eyesight

[0099] N-acetylneuraminic acid can promote the regeneration of rhodopsin in the retina and also promote the regeneration of retinaldehyde in the retina, which can improve vision to a certain extent.

[0100] 5. Promotes liver detoxification

[0101] N-acetylneuraminic acid can also promote liver detoxification because it can promote liver metabolism and, to some extent, enhance the liver's detoxification ability.

[0102] In the embodiments of this application, the mass ratio of thiamine to riboflavin is 2:1.

[0103] In this embodiment, the special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders includes 0.1-5% DHA algal oil. Further, the mass ratio of small molecule peptides to DHA algal oil is (8-15):1.

[0104] DHA algal oil powder (brain gold) is an oil extracted from marine microalgae. Its main component is docosahexaenoic acid (DHA), an important member of the Omega-3 unsaturated fatty acid family, which has many positive effects on the human body, including the following:

[0105] 1. Promotes brain development: DHA is an important structural fatty acid in the brain and retina, playing a vital role in the brain and vision development of infants and young children. DHA supplementation by pregnant and breastfeeding women can be passed to the infant through the placenta and breast milk, contributing to the development of the infant's nervous system.

[0106] 2. Improve cardiovascular and cerebrovascular health: DHA can lower triglyceride and cholesterol levels in the blood, reduce the risk of atherosclerosis, and play a positive role in preventing cardiovascular and cerebrovascular diseases; it can also improve the elasticity of cerebral blood vessels, prevent cerebral arteriosclerosis, and thus improve cerebral blood supply.

[0107] 3. Maintaining vision health: DHA is an important component of retinal cells and plays a positive role in maintaining retinal function and preventing eye diseases.

[0108] 4. Anti-inflammatory effect: DHA has a certain anti-inflammatory effect, which can reduce the production of inflammatory mediators and may be helpful in the adjunctive treatment of some inflammatory diseases.

[0109] 5. Improve cognitive function: Studies have shown that DHA has a positive effect on improving cognitive function and preventing neurodegenerative diseases such as Alzheimer's disease.

[0110] 6. Mood Regulation: DHA also plays a role in mood regulation. Studies have shown that adequate DHA supplementation may help alleviate depressive symptoms.12

[0111] 7. Enhances the body's resistance: DHA algal oil can enhance the body's immunity, improve the body's resistance, and reduce the occurrence of diseases. It is beneficial for people of all ages, especially infants and the elderly.

[0112] In the embodiments of this application, the excipients may include sweeteners, flavor modifiers, etc. Specifically, the sweetener may include at least one of maltitol and erythritol; preferably, a combination of maltitol and erythritol; the flavor modifier is preferably citric acid. Further, the amount of citric acid added is ≤10% of the total amount of maltitol and erythritol added.

[0113] In this embodiment of the application, a method for preparing a special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders includes the following specific steps:

[0114] S1. First, dissolve the plant extract in purified water and mix thoroughly to obtain a mixed solution;

[0115] S2. Add small molecule peptides, γ-aminobutyric acid, N-acetylneuraminic acid, thiamine, riboflavin and excipients, mix evenly, filter, sterilize and fill to obtain a special dietary supplement of ginseng and sesame compound peptides that improves cardiovascular and cerebrovascular diseases and microcirculation disorders.

[0116] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0117] Preparation Example 1

[0118] The preparation steps of plant extracts include:

[0119] A1. Take the following ingredients in a mass ratio of 1:1:1:1:1:1:1:1:1:1:1 as the plant raw materials: Mosla chinensis, dried ginger, ginseng, coix seed, honeysuckle, cinnamon, licorice, angelica dahurica, apricot kernel, and schizonepeta tenuifolia. Soak them in 10 times the amount of drinking water for more than 2 hours. Heat the mixture to boiling and keep it boiling for 1.5 hours. Filter the mixture through a 100-mesh sieve to obtain the first plant extract.

[0120] A2. Add 8 times the amount of drinking water as plant material to the filter residue, heat to boiling, maintain boiling for 1 hour, filter through a 100-mesh sieve to obtain the second plant extract; mix the first and second plant extracts to obtain the mixed plant pulp.

[0121] A3. The plant pulp was concentrated to a density of 1.2 to 1.3 at 60–85°C to obtain a concentrated plant extract.

[0122] Preparation Example 2

[0123] The preparation steps of plant extracts include:

[0124] A1. Take dried ginger, ginseng, coix seed, honeysuckle, cinnamon, licorice, angelica, apricot kernel and schizonepeta in a mass ratio of 1:1:1:1:1:1:1:1:1 as plant raw materials, add 10 times the amount of drinking water and soak for more than 2 hours, turn on the heat to boil, keep boiling for 1.5 hours, and then filter through a 100-mesh sieve to obtain the first plant extract;

[0125] A2. Add 8 times the amount of drinking water as plant material to the filter residue, heat to boiling, maintain boiling for 1 hour, filter through a 100-mesh sieve to obtain the second plant extract; mix the first and second plant extracts to obtain the mixed plant pulp.

[0126] A3. The plant pulp was concentrated to a density of 1.2 to 1.3 at 60–85°C to obtain a concentrated plant extract.

[0127] Preparation Example 3

[0128] The preparation steps of plant extracts include:

[0129] A1. Take the following ingredients in a mass ratio of 1:1:1:1:1:1:1:1:1:1 as the plant raw materials: Mosla chinensis, ginseng, coix seed, honeysuckle, cinnamon, licorice, angelica dahurica, apricot kernel, and schizonepeta tenuifolia. Soak them in 10 times the amount of drinking water for more than 2 hours. Heat the mixture to boiling and keep it boiling for 1.5 hours. Filter the mixture through a 100-mesh sieve to obtain the first plant extract.

[0130] A2. Add 8 times the amount of drinking water as plant material to the filter residue, heat to boiling, maintain boiling for 1 hour, filter through a 100-mesh sieve to obtain the second plant extract; mix the first and second plant extracts to obtain the mixed plant pulp.

[0131] A3. The plant pulp was concentrated to a density of 1.2 to 1.3 at 60–85°C to obtain a concentrated plant extract.

[0132] Preparation Example 4

[0133] The preparation steps of plant extracts include:

[0134] A1. Take the following ingredients in a mass ratio of 1:1:1:1:1:1:1:1:1:1 as the plant raw materials: Mosla chinensis, dried ginger, coix seed, honeysuckle, cinnamon, licorice, angelica dahurica, apricot kernel, and schizonepeta tenuifolia. Soak them in 10 times the amount of drinking water for more than 2 hours. Heat the mixture to boiling and keep it boiling for 1.5 hours. Filter the mixture through a 100-mesh sieve to obtain the first plant extract.

[0135] A2. Add 8 times the amount of drinking water as plant material to the filter residue, heat to boiling, maintain boiling for 1 hour, filter through a 100-mesh sieve to obtain the second plant extract; mix the first and second plant extracts to obtain the mixed plant pulp.

[0136] A3. The plant pulp was concentrated to a density of 1.2 to 1.3 at 60–85°C to obtain a concentrated plant extract.

[0137] Example 1

[0138] A method for preparing a special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders, the specific steps of which are as follows:

[0139] S1. Dissolve 500g of the concentrated plant extract from Preparation Example 1 in purified water, and add purified water to 2000mL. Stir and mix well to obtain a mixed solution.

[0140] S2. Add small molecule peptides, γ-aminobutyric acid, N-acetylneuraminic acid, DHA algal oil, thiamine, riboflavin and excipients as shown in Table 1, stir and mix evenly, filter, sterilize and fill to obtain a special dietary supplement of ginseng and sesame compound peptides that improves cardiovascular and cerebrovascular diseases and microcirculation disorders.

[0141] Example 2

[0142] The difference from Example 1 is that it does not contain earthworm protein powder.

[0143] Comparative Examples 1-3

[0144] The difference from Example 1 is that the plant extract concentrates prepared in Examples 2 to 4 are selected respectively.

[0145] Comparative Example 4

[0146] The difference from Example 1 is that it does not contain γ-aminobutyric acid.

[0147] Comparative Example 5

[0148] The difference from Example 1 is that it does not contain N-acetylneuraminic acid.

[0149] Table 1

[0150]

[0151] Parameter measurement

[0152] Two hundred and ten healthy male rats weighing 120-160g were selected for the experiment and randomly divided into seven groups of 30 rats each: experimental groups 1-2 and control groups 1-5. Each group of mice was administered a high-fat, high-salt diet (composed of 10% salt, 20% lard, 15% egg yolk, and the remainder as basal food) by gavage daily for four weeks to establish a rat model of hypertension and hyperlipidemia. The following lipid levels were measured in the rats: serum total cholesterol (TC), serum triglycerides (TG), serum high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C).

[0153] After the model was established, rats in experimental groups 1-2 were administered the special diet of Examples 1-2 of this application by gavage daily, while rats in control groups 1-5 were administered the same amount of the special diet of Comparative Examples 1-5 by gavage daily. Following the gavage standard of 0.02 mL / g of the special diet, rats were gavaged once daily for 30 consecutive days, with all other culture conditions remaining the same for each group. After the experiment, the following lipid levels (serum total cholesterol (TC), serum triglyceride (TG), serum high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C)) were measured in the rats. The results are shown in Table 2 below.

[0154] Table 2

[0155]

[0156] Based on the above results, after long-term consumption of the special dietary supplement containing ginseng and sesame compound peptides proposed in this application for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders, consumers can effectively reduce blood lipids (triglycerides, cholesterol, and low-density lipoprotein cholesterol), increase capillary elasticity and permeability, improve microcirculation, and effectively prevent and alleviate cardiovascular and cerebrovascular diseases.

[0157] The various embodiments of this application have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders, characterized in that, It includes the following components: 5-15% small molecule peptides; 18-65% plant extracts; 0.1-3% γ-aminobutyric acid; N-acetylneuraminic acid 0.01–1%; thiamine 0.005–0.1%; riboflavin 0.001–0.05%; the remainder are excipients; The plant extract contains at least one of Elsholtzia ciliata, dried ginger, and ginseng.

2. The special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The small molecule peptides include earthworm protein powder.

3. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The small molecule peptides also include at least one of wheat oligopeptides and collagen peptides; and the mass ratio of earthworm protein powder, wheat oligopeptides, and collagen peptides is (1.5-3):1:

1.

4. The special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The mass ratio of Elsholtzia ciliata, dried ginger and ginseng in the plant extract is 1:1:

1.

5. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The plant extract also includes at least one of the following: coix seed, honeysuckle, cinnamon, licorice, angelica, almond, and schizonepeta.

6. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The mass ratio of the small molecule peptide to the plant extract is 1:(3.5-4.5).

7. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: It also includes 0.1-5% DHA algal oil.

8. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The preparation steps of the plant extract include: A1. Take plant raw materials, soak them in drinking water for 2-3 hours, heat to boiling, boil for 1-2.5 hours, and then filter to obtain the first plant extract; A2. Add drinking water to the filter residue and heat to boiling. After boiling for 1 to 2.5 hours, filter to obtain the second plant extract. Repeat the boiling step 0 to 3 times and mix the plant extracts to obtain the mixed plant pulp. A3. The plant pulp was concentrated at 60–85°C to obtain a concentrated plant extract.

9. The special dietary supplement containing Elsholtzia ciliata and ginseng compound peptides for improving cardiovascular and cerebrovascular diseases and microcirculatory disorders according to claim 1, characterized in that: The density of the plant extract concentrate is 1.0 to 1.

5.

10. A method for preparing a special dietary supplement containing Elsholtzia ciliata and ginseng complex peptides to improve cardiovascular and cerebrovascular diseases and microcirculatory disorders, characterized in that, The specific steps are as follows: S1. First, dissolve the plant extract in purified water and mix thoroughly to obtain a mixed solution; S2. Add small molecule peptides, γ-aminobutyric acid, N-acetylneuraminic acid, thiamine, riboflavin and excipients, mix evenly, filter, sterilize and fill to obtain a special dietary supplement of ginseng and sesame compound peptides that improves cardiovascular and cerebrovascular diseases and microcirculation disorders.

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