Skin repairing mask and preparation method thereof

Abstract

The invention discloses a skin repair mask and a preparation method thereof, and relates to the technical field of facial beauty care, the skin repair mask comprises a mask base material and mask liquid attached to the mask base material, the NMN / retinol palmitate / ergothioneine compound nanocrystal moisturizing and repairing lotion is prepared from the following components in parts by weight: 0.5 to 3.0 parts of liposome-coated NMN, 0.3 to 2.0 parts of retinol palmitate / ergothioneine compound nanocrystal, 5.0 to 15.0 parts of moisturizing and repairing component, 0.1 to 2.0 parts of soothing and anti-inflammatory component, 0.1 to 0.8 part of thickening agent, 0.1 to 0.5 part of preservative, 0.01 to 0.1 part of chelating agent, 0.01 to 0.2 part of essence and the balance of deionized water, wherein the total amount of the components is 100 parts. The mask has anti-aging and deep repairing effects, has a good anti-allergic effect, and is adaptive to sensitive skin.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a skin repair mask and its preparation method. Background Technology

[0002] With the deterioration of the environment, irregular lifestyles, and improper skincare practices, more and more people are facing problems such as damaged skin barriers and accelerated aging. These manifest as dry, rough, sensitive, and red skin, increased fine lines, and decreased elasticity, seriously affecting skin health and appearance. Skin repair masks, as convenient and effective skincare products, can quickly replenish skin moisture, soothe irritation, and repair damaged barriers, making them one of the core categories in consumers' daily skincare routines.

[0003] Currently, most skin repair masks on the market focus on moisturizing and soothing ingredients, such as sodium hyaluronate, panthenol, and centella asiatica extract. These only provide basic moisturizing and superficial soothing effects, failing to address skin aging and deep repair at the cellular level. With the increasing demand for anti-aging skincare, anti-aging active ingredients such as NMN (nicotinamide mononucleotide), retinyl palmitate, and ergothioneine are widely used in the skincare field; among them, NMN can replenish skin cells... At the same level, it activates cellular energy metabolism and promotes DNA repair. Retinyl palmitate can promote collagen synthesis, and ergothioneine can scavenge free radicals. The three can work together to significantly enhance the anti-aging effect, but there are obvious technical bottlenecks in its application.

[0004] In existing technologies, NMN is usually added to cosmetics in a free state. The free NMN molecule is unstable and easily degraded by enzymes on the skin surface, making it unable to reach dermal cells completely, resulting in significant loss of activity. Furthermore, free NMN is highly water-soluble and poorly lipid-soluble, making it difficult to penetrate the skin's stratum corneum barrier and effectively enter cells to replenish nutrients. Currently, NMN is difficult to exert its anti-aging effects at the cellular level. Furthermore, it is easily hydrolyzed and oxidized in aqueous mask solutions, exhibiting poor storage stability and potentially causing slight irritation to sensitive skin. Additionally, the anti-aging effects of NMN alone are relatively limited. Retinyl palmitate is easily oxidized and decomposed; ergot thiocyanate is highly water-soluble but weakly lipid-soluble, and since skin cell membranes are primarily composed of a lipid bilayer, it is difficult for it to penetrate the skin cell membrane barrier in its free state. Most of it remains on the skin surface and is easily metabolized and lost, failing to fully exert its biological activity. Existing technologies sometimes attempt to add only one active ingredient or simply mix them, but this fails to achieve synergistic delivery of two (or similar) active ingredients, resulting in poor anti-aging and repair effects. Simultaneously, some products attempt to improve transdermal efficiency by adding penetration enhancers, but these often irritate the skin, especially for sensitive skin, and their penetration-enhancing effects are limited.

[0005] Furthermore, existing skin repair masks suffer from poor formulation synergy. Most products simply mix multiple active ingredients without considering their interactions, leading to decreased stability of some active ingredients, diminished synergistic effects, and even antagonistic reactions. Additionally, some masks employ rudimentary manufacturing processes, failing to guarantee the uniform dispersion and effective retention of active ingredients, further impacting product efficacy and safety.

[0006] Therefore, developing a skin repair mask that combines anti-aging and deep repair effects has become a pressing technical challenge in the cosmetics industry. Summary of the Invention

[0007] The purpose of this invention is to overcome the shortcomings of existing technologies by providing a skin repair mask and its preparation method. By using nanocrystal delivery technology and liposome encapsulation technology, the technical bottleneck of anti-aging active ingredients being unable to penetrate the skin cell membrane and having low bioavailability is solved. At the same time, the formula and preparation process are optimized to achieve synergistic effects of anti-aging and deep skin repair.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is: a skin repair mask, comprising a mask substrate and a mask liquid attached to the mask substrate, wherein the mask liquid, by weight, comprises the following components: 0.5-3.0 parts of liposome-encapsulated NMN, 0.3-2.0 parts of retinyl palmitate / ergothioneine complex nanocrystals, 5.0-15.0 parts of moisturizing and repairing components, 0.1-2.0 parts of soothing and anti-inflammatory components, 0.1-0.8 parts of thickener, 0.1-0.5 parts of preservative, 0.01-0.1 parts of chelating agent, 0.01-0.2 parts of fragrance, and deionized water to make up to 100 parts.

[0009] Preferably, the method for preparing the liposome-encapsulated NMN includes the following steps: adding lecithin and cholesterol to anhydrous ethanol, placing it in a constant temperature water bath at 60-70℃, and stirring to obtain a homogeneous and transparent lipid organic solution; transferring the solution to a rotary evaporator, controlling the rotation speed at 30-50 r / min and the water bath temperature at 45-55℃, and slowly rotating to evaporate and remove the anhydrous ethanol until a uniform and dense blank liposome film is formed on the inner wall of the container; preparing a phosphate buffer solution with pH=6.0-7.0, dissolving NMN in the buffer solution to obtain an NMN buffer solution with a concentration of 10-20 mg / mL; slowly adding the NMN buffer solution to the prepared blank liposome film, placing it in a water bath at 30-35℃, and stirring to hydrate for 30- After 40 minutes, a crude liposome suspension was obtained. The crude liposome suspension was transferred to a high-pressure homogenizer, and the homogenization temperature was controlled at ≤30℃. The homogenization was performed 1-2 times at a pressure of 600-800 bar to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, the suspension was filtered using a 0.22μm microporous membrane to remove impurities and large particle size agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ low-temperature freezer for 2 hours, and then transferred to a freeze dryer. The freeze-drying temperature was controlled at -25℃~-35℃ and the vacuum degree was 10-30Pa. The mixture was freeze-dried for 12-16 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained.

[0010] Preferably, the mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol is [missing information]. (5-7):1:(30-40):(0.5-2):(2.5-7).

[0011] Preferably, the preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: first, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a water bath at 35-40°C for 10-15 min at a stirring speed of 500-800 r / min until completely dissolved, obtaining an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 8-12 min at a stirring speed of 600 r / min until completely dissolved, obtaining an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 1-2 mL / min, while maintaining stirring at room temperature during the dropping process, increasing the stirring speed to 1200-1500 r / min, and continuing stirring for 2 minutes after the dropping is completed. A uniform and fine pre-emulsion was obtained after 0 min. The pre-emulsion was then transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads were added. The milling speed was adjusted to 2200-2800 r / min, and the milling time was 40-50 min. During the milling process, a circulating water bath was used to control the temperature, and the temperature of the milling system was strictly controlled at 25-30℃. The milling equipment was kept away from light throughout the process. After milling, the milling liquid was removed and vacuum filtered using a 0.45μm cosmetic-grade filter membrane to remove large particles of impurities that were not milled evenly and a small amount of residual zirconia bead debris, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried into retinyl palmitate / ergothioneine complex nanocrystals using freeze-drying technology.

[0012] Preferably, the cosmetic-grade zirconia beads have a particle size of 0.2 mm, and the volume ratio of zirconia beads to pre-emulsion is 2:1; the mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water is (0.5-1.0):(0.2-0.5):(2.0-3.0):(0.1-0.3):(0.3-0.6):(1.0-1.5):(0.8-1.2):(85-90).

[0013] Preferably, the moisturizing and repairing components, by weight, consist of the following components: 3.0-8.0 parts glycerin, 0.1-0.5 parts sodium hyaluronate, 1.0-3.0 parts panthenol, 0.5-2.0 parts hydrolyzed collagen, and 0.1-0.5 parts ceramide NP.

[0014] Preferably, the soothing and anti-inflammatory component is composed of the following components by weight: 0.05-0.5 parts of Centella asiatica extract, 0.03-0.3 parts of dipotassium glycyrrhizate, and 0.02-0.2 parts of Myrtle extract.

[0015] Preferably, the Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%; the Myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0016] Preferably, the preservative is at least one of sorbic acid and potassium sorbate.

[0017] Preferably, the thickener is at least one of carbomer 940 and sodium carboxymethyl cellulose.

[0018] Preferably, the chelating agent is EDTA-disodium.

[0019] Preferably, the mask substrate is a bio-cellulose mask fabric; the bio-cellulose mask fabric has a thickness of 0.1-0.3 mm and a porosity of 70%-85%.

[0020] Another objective of this invention is to provide a method for preparing the skin repair mask, comprising the following steps: mixing the components of the mask liquid evenly according to their weight proportions, placing them in a vacuum degassing tank, and degassing them for 10-15 minutes under a vacuum of 0.05-0.07 MPa; after degassing, detecting the pH value of the mask liquid, and adjusting the pH value to 5.5-6.5 to obtain the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape that conforms to the facial contour, with each mask having an area of ​​20-25 cm², and evenly applying the mask liquid onto the mask substrate, with each mask having a mask liquid loading of 25-30 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 20-25℃ and the relative humidity at 40%-60% during the packaging process; and storing the sealed mask in a low-temperature cold storage.

[0021] Due to the application of the above technical solution, the present invention has the following beneficial effects: (1) The skin repair mask and its preparation method disclosed in this invention overcome the technical bottleneck of existing technologies where a single delivery system cannot simultaneously achieve the transdermal efficiency and stability of multiple active components by using liposome encapsulation technology and nanocrystal delivery technology, thus achieving a synergistic effect. Existing technologies mostly use liposome encapsulation or simple mixing of active components alone, which cannot solve the problem of the solubility difference between lipid-soluble and water-soluble anti-aging components, resulting in low bioavailability. In contrast, this invention specifically prepares a complex nanocrystal of highly lipid-soluble retinyl palmitate and highly water-soluble ergothioneine, and simultaneously uses liposome encapsulation of NMN. The particle sizes of the two delivery systems are compatible with each other, and they can synergistically penetrate the stratum corneum of the skin to reach the dermal cells. Compared with products with a single delivery system, the skin cell absorption rate of NMN, retinyl palmitate, and ergothioneine is significantly improved, effectively solving the core pain point of anti-aging active components being difficult to penetrate the skin cell membrane and having low bioavailability. Its synergistic transdermal effect far exceeds the simple superposition of the two delivery technologies and has significant non-obviousness.

[0022] (2) The skin repair mask and its preparation method disclosed in this invention, with optimized active ingredient preparation process and ratio, significantly improve the stability and efficacy of the product, achieving technical effects that cannot be achieved by existing technologies. In existing technologies, liposome encapsulation often leads to liposome rupture and loss of active ingredients due to imbalance of component ratios, while nanocrystal preparation is prone to problems such as agglomeration and uneven particle size; however, this invention clarifies the optimal component mass ratio of liposome-encapsulated NMN and complex nanocrystals, precisely controls key parameters such as temperature, rotation speed, and homogenization pressure during the preparation process, and effectively protects retinyl palmitate from oxidation through the combination of vitamin E and panthenol, ensuring stable liposome bilayer structure and uniform dispersion of nanocrystals without agglomeration, thus greatly extending the product shelf life and reducing production and storage costs.

[0023] (3) The skin repair mask and its preparation method disclosed in this invention achieve a dual effect of anti-aging and deep skin repair through the scientific compounding and synergistic design of the formula components. It solves the technical defects of existing masks with single effects and poor formula synergy. Moreover, it is safe and suitable for sensitive skin people, and the effect exceeds expectations. Most existing skin repair masks can only achieve basic moisturizing and soothing, while anti-aging masks often neglect skin barrier repair and are prone to irritating sensitive skin. This invention precisely compoundes dual core anti-aging components with moisturizing and repairing components and soothing and anti-inflammatory components. The moisturizing and repairing components can provide a good skin environment for the anti-aging components to play their role, while the soothing and anti-inflammatory components can effectively reduce the potential irritation of liposomes and nanocrystals to the skin. At the same time, the source and effective content of key extracts are clearly defined to further ensure the stability of efficacy. It can not only effectively improve the aging state of the skin, but also quickly repair the damaged skin barrier. It is suitable for all skin types, especially sensitive skin. Its comprehensive efficacy far exceeds that of existing single-effect or simply compounded mask products.

[0024] (4) The skin repair mask and its preparation method disclosed in this invention take into account both efficacy and industrial feasibility. While enhancing the core competitiveness of the product, it reduces the difficulty and cost of production, and has practical value that cannot be matched by existing technologies. In the prior art, some high-efficiency anti-aging masks require complex preparation processes or expensive raw materials and equipment, making it difficult to achieve large-scale industrial production; while the raw materials used in this invention are all conventional raw materials in the cosmetics industry, the preparation process steps are clear and the parameters are well-defined, no special expensive equipment is required, and through precise component ratio and process control, the quality of the product is ensured to be stable between batches, making it suitable for large-scale industrial production. At the same time, this invention optimizes the specifications of the mask substrate and the loading parameters of the mask liquid, so that the mask liquid can be evenly attached and slowly release active ingredients, further improving the efficacy utilization rate. Compared with the prior art, without increasing the production cost, it achieves simultaneous improvement in product efficacy, stability and safety, and has significant market application advantages and promotion value.

[0025] (5) The skin repair mask and its preparation method disclosed in this invention, wherein the mask liquid is composed of the following components by weight: 0.5-3.0 parts of liposome-encapsulated NMN, 0.3-2.0 parts of retinyl palmitate / ergothioneine complex nanocrystals, 5.0-15.0 parts of moisturizing and repairing components, 0.1-2.0 parts of soothing and anti-inflammatory components, 0.1-0.8 parts of thickener, 0.1-0.5 parts of preservative, 0.01-0.1 parts of chelating agent, 0.01-0.2 parts of fragrance, and deionized water to make up to 100 parts. The moisturizing and repairing components are composed of the following components by weight: 3.0-8.0 parts of glycerin, 0.1-0.5 parts of sodium hyaluronate, 1.0-3.0 parts of panthenol, 0.5-2.0 parts of hydrolyzed collagen, and 0.1-0.5 parts of ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: Centella asiatica extract 0.05-0.5 parts, dipotassium glycyrrhizate 0.03-0.3 parts, and Myrtle extract 0.02-0.2 parts. Through the synergistic effect of these components, the resulting skin-repairing mask possesses both highly effective anti-aging and deep-repairing properties, while also achieving excellent moisturizing and soothing effects, and ensuring safety and stability. Detailed Implementation

[0026] The following description is intended to disclose the invention and enable those skilled in the art to implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art.

[0027] Example 1 A skin repair mask includes a mask base and a mask liquid attached to the mask base. The mask liquid, by weight, consists of the following components: 0.5 parts of liposome-encapsulated NMN, 0.3 parts of retinyl palmitate / ergothioneine complex nanocrystals, 5.0 parts of moisturizing and repairing components, 0.1 parts of soothing and anti-inflammatory components, 0.1 parts of thickener, 0.1 parts of preservative, 0.01 parts of chelating agent, 0.01 parts of fragrance, and deionized water to make up to 100 parts.

[0028] The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a 60°C constant temperature water bath, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 30 r / min and the water bath temperature at 45°C, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=6.0 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 10 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a 30°C water bath, and stirred for hydration for 30 min to obtain a crude liposome suspension; the crude liposome suspension is transferred... The mixture was homogenized once in a high-pressure homogenizer at a temperature ≤30℃ to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, it was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ freezer for 2 hours and then transferred to a freeze dryer. The freeze-drying temperature was controlled at -25℃ and the vacuum degree at 10Pa for 12 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained. The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol was 5:1:30:0.5:2.5.

[0029] The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: First, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a 35°C water bath for 10 minutes at a stirring speed of 500 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 8 minutes at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 1 mL / min, while maintaining room temperature stirring during the dropping process, and increasing the stirring speed to 1200 r / min; after the dropping is completed, stirring is continued for 20 minutes to obtain a homogeneous and fine pre-emulsion; the above pre-emulsion is transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads are added; the milling speed is adjusted to 2200 r / min. The grinding time was 40 minutes, and a circulating water bath was used for temperature control during the grinding process, strictly controlling the temperature of the grinding system at 25℃. The grinding equipment was kept completely dark throughout the process. After grinding, the grinding liquid was removed and vacuum filtered through a 0.45μm cosmetic-grade filter membrane to remove large, unevenly ground impurities and residual zirconia bead fragments, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried into retinyl palmitate / ergothioneine complex nanocrystals using freeze-drying technology. The cosmetic-grade zirconia beads had a particle size of 0.2mm, and the volume ratio of zirconia beads to pre-emulsion was 2:1. The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water was 0.5:0.2:2.0:0.1:0.3:1.0:0.8:85.

[0030] The moisturizing and repairing components, by weight, consist of the following: 3.0 parts glycerin, 0.1 parts sodium hyaluronate, 1.0 part panthenol, 0.5 parts hydrolyzed collagen, and 0.1 parts ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: 0.05 parts Centella asiatica extract, 0.03 parts dipotassium glycyrrhizate, and 0.02 parts myrtle extract. The Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%. The myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0031] The preservative is sorbic acid; the thickener is carbomer 940; the chelating agent is EDTA-disodium; the mask substrate is a bio-cellulose mask cloth; the bio-cellulose mask cloth has a thickness of 0.1 mm and a porosity of 70%.

[0032] A method for preparing the skin repair mask includes the following steps: Mixing the components of the mask liquid evenly according to their weight proportions, placing it in a vacuum degassing tank, and degassing for 10 minutes under a vacuum of 0.05 MPa; after degassing, detecting the pH value of the mask liquid, adjusting the pH value to 5.5 to obtain the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape conforming to the facial contour, with each mask having an area of ​​20 cm², and evenly applying the mask liquid to the mask substrate, with each mask having a mask liquid loading of 25 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 20°C and the relative humidity at 40% during the packaging process; storing the sealed mask in a low-temperature cold storage.

[0033] Example 2 A skin repair mask includes a mask base and a mask liquid attached to the mask base. The mask liquid, by weight, consists of the following components: 1.5 parts of liposome-encapsulated NMN, 1 part of retinyl palmitate / ergothioneine complex nanocrystals, 9 parts of moisturizing and repairing components, 0.8 parts of soothing and anti-inflammatory components, 0.3 parts of thickener, 0.2 parts of preservative, 0.04 parts of chelating agent, 0.08 parts of fragrance, and deionized water to make up to 100 parts.

[0034] The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a 63°C constant temperature water bath, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 35 r / min and the water bath temperature at 47°C, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=6.3 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 13 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a 32°C water bath, and stirred for hydration for 33 min to obtain a crude liposome suspension; the crude liposome suspension is then transferred to a rotary evaporator. The mixture was transferred to a high-pressure homogenizer, and homogenized twice at 650 bar pressure, with the homogenization temperature controlled at ≤30℃, to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, it was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant, and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ freezer for 2 hours, and then transferred to a freeze dryer, with the freeze-drying temperature controlled at -28℃ and the vacuum degree at 15Pa, for 13 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained. The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol was 5.5:1:33:1:4.

[0035] The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: First, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a 37°C water bath for 12 minutes at a stirring speed of 600 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 9 minutes at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 1.2 mL / min, while maintaining stirring at room temperature during the dropping process, and increasing the stirring speed to 1300 r / min. After the dropping is completed, stirring is continued for 20 minutes to obtain a homogeneous and fine pre-emulsion; the above pre-emulsion is transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads are added; the milling speed is adjusted to 2400 r / min. The grinding time was 43 minutes. A circulating water bath was used for temperature control during the grinding process, strictly maintaining the grinding system temperature at 26℃. The grinding equipment was kept completely dark throughout the process. After grinding, the grinding liquid was removed and vacuum filtered through a 0.45μm cosmetic-grade filter membrane to remove large, unevenly ground impurities and residual zirconia bead fragments, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried using freeze-drying technology to obtain retinyl palmitate / ergothioneine complex nanocrystals. The cosmetic-grade zirconia beads had a particle size of 0.2mm, and the volume ratio of zirconia beads to the pre-emulsion was 2:1. The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water was 0.6:0.3:2.3:0.15:0.4:1.2:0.9:87.

[0036] The moisturizing and repairing components, by weight, consist of the following: 5.0 parts glycerin, 0.2 parts sodium hyaluronate, 1.5 parts panthenol, 1 part hydrolyzed collagen, and 0.2 parts ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: 0.2 parts Centella asiatica extract, 0.1 parts dipotassium glycyrrhizate, and 0.1 parts myrtle extract. The Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%. The myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0037] The preservative is potassium sorbate; the thickener is sodium carboxymethyl cellulose; the chelating agent is disodium EDTA; the mask substrate is a bio-cellulose mask fabric; the bio-cellulose mask fabric has a thickness of 0.2 mm and a porosity of 75%.

[0038] A method for preparing the skin repair mask includes the following steps: Mixing the components of the mask liquid evenly according to their weight proportions, placing it in a vacuum degassing tank, and degassing it for 12 minutes under a vacuum of 0.055 MPa; after degassing, detecting the pH value of the mask liquid, adjusting the pH value to 5.8 to obtain the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape conforming to the facial contour, with each mask having an area of ​​22 cm², and evenly applying the mask liquid to the mask substrate, with each mask having a mask liquid loading of 27 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 22°C and the relative humidity at 45% during the packaging process; storing the sealed mask in a low-temperature cold storage.

[0039] Example 3 A skin repair mask includes a mask base and a mask liquid attached to the mask base. The mask liquid, by weight, consists of the following components: 2 parts of liposome-encapsulated NMN, 1.3 parts of retinyl palmitate / ergothioneine complex nanocrystals, 10 parts of moisturizing and repairing components, 1.3 parts of soothing and anti-inflammatory components, 0.5 parts of thickener, 0.3 parts of preservative, 0.06 parts of chelating agent, 0.13 parts of fragrance, and deionized water to make up to 100 parts.

[0040] The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a 65°C constant temperature water bath, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 40 r / min and the water bath temperature at 50°C, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=6.5 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 15 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a 33°C water bath, and stirred for hydration for 35 min to obtain a crude liposome suspension; the crude liposome suspension is then transferred to a rotary evaporator. The mixture was transferred to a high-pressure homogenizer, and homogenized once at 700 bar pressure, with the homogenization temperature controlled at ≤30℃, to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, it was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant, and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ freezer for 2 hours, and then transferred to a freeze dryer, with the freeze-drying temperature controlled at -30℃ and the vacuum degree at 20Pa, for 14 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained. The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol was 6:1:35:1.3:4.

[0041] The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: First, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a 38°C water bath for 13 minutes at a stirring speed of 650 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 10 minutes at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 1.5 mL / min, while maintaining stirring at room temperature during the dropping process, and increasing the stirring speed to 1350 r / min. After the dropping is completed, stirring is continued for 20 minutes to obtain a homogeneous and fine pre-emulsion; the above pre-emulsion is transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads are added; the milling speed is adjusted to 2500 r / min. The grinding process was carried out for 45 minutes, with a circulating water bath used for temperature control, strictly maintaining the grinding system temperature at 28℃. The grinding equipment was kept completely dark throughout the process. After grinding, the grinding solution was removed and vacuum filtered through a 0.45μm cosmetic-grade filter membrane to remove large, unevenly ground impurities and residual zirconia bead fragments, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried using freeze-drying technology to obtain retinyl palmitate / ergothioneine complex nanocrystals. The cosmetic-grade zirconia beads had a particle size of 0.2mm, and the volume ratio of zirconia beads to pre-emulsion was 2:1. The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water was 0.8:0.35:2.5:0.2:0.45:1.3:1:88.

[0042] The moisturizing and repairing components, by weight, consist of the following: 6.0 parts glycerin, 0.35 parts sodium hyaluronate, 2.0 parts panthenol, 1.3 parts hydrolyzed collagen, and 0.35 parts ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: 0.35 parts Centella asiatica extract, 0.2 parts dipotassium glycyrrhizate, and 0.1 parts myrtle extract. The Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%. The myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0043] The preservative is sorbic acid; the thickener is carbomer 940; the chelating agent is EDTA-disodium; the mask substrate is a bio-cellulose mask cloth; the bio-cellulose mask cloth has a thickness of 0.2 mm and a porosity of 80%.

[0044] A method for preparing the skin repair mask includes the following steps: Mixing the components of the mask liquid evenly according to their weight proportions, placing it in a vacuum degassing tank, and degassing for 13 minutes under a vacuum of 0.06 MPa; after degassing, detecting the pH value of the mask liquid, adjusting the pH value to 6, and obtaining the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape conforming to the facial contour, with each mask having an area of ​​23 cm², and evenly applying the mask liquid to the mask substrate, with each mask having a mask liquid loading of 28 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 23°C and the relative humidity at 50% during the packaging process; and storing the sealed mask in a low-temperature cold storage.

[0045] Example 4 A skin repair mask includes a mask base and a mask liquid attached to the mask base. The mask liquid, by weight, consists of the following components: 2.5 parts of liposome-encapsulated NMN, 1.5 parts of retinyl palmitate / ergothioneine complex nanocrystals, 13.0 parts of moisturizing and repairing components, 1.8 parts of soothing and anti-inflammatory components, 0.7 parts of thickener, 0.4 parts of preservative, 0.08 parts of chelating agent, 0.16 parts of fragrance, and deionized water to make up to 100 parts.

[0046] The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a 68°C constant temperature water bath, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 45 r / min and the water bath temperature at 53°C, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=6.8 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 18 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a 34°C water bath, and stirred for hydration for 38 min to obtain a crude liposome suspension; the crude liposome suspension is transferred... The mixture was homogenized twice in a high-pressure homogenizer at a temperature ≤30℃ to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, it was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ freezer for 2 hours and then transferred to a freeze dryer. The freeze-drying temperature was controlled at -33℃ and the vacuum degree at 25Pa for 15 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained. The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol was 6.5:1:38:1.8:6.

[0047] The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: First, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a 39°C water bath for 14 min at a stirring speed of 750 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 11 min at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 1.8 mL / min, while maintaining room temperature stirring during the dropping process, and increasing the stirring speed to 1450 r / min; after the dropping is completed, stirring is continued for 20 min to obtain a homogeneous and fine pre-emulsion; the above pre-emulsion is transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads are added; the milling speed is adjusted to 2700 r / min. The grinding time was 48 minutes. During the grinding process, a circulating water bath was used to control the temperature of the grinding system, strictly maintaining it at 29℃. The grinding equipment was kept completely dark throughout the process. After grinding, the grinding liquid was removed and vacuum filtered through a 0.45μm cosmetic-grade filter membrane to remove large, unevenly ground impurities and residual zirconia bead fragments, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried into retinyl palmitate / ergothioneine complex nanocrystals using freeze-drying technology. The cosmetic-grade zirconia beads had a particle size of 0.2mm, and the volume ratio of zirconia beads to the pre-emulsion was 2:1. The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water was 0.9:0.45:2.8:0.25:0.55:1.4:1.1:89.

[0048] The moisturizing and repairing components, by weight, consist of the following: 7.0 parts glycerin, 0.4 parts sodium hyaluronate, 2.5 parts panthenol, 1.8 parts hydrolyzed collagen, and 0.4 parts ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: 0.45 parts Centella asiatica extract, 0.25 parts dipotassium glycyrrhizate, and 0.18 parts myrtle extract. The Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%. The myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0049] The preservative is a mixture of sorbic acid and potassium sorbate in a mass ratio of 1:3; the thickener is a mixture of carbomer 940 and sodium carboxymethyl cellulose in a mass ratio of 1:1; the chelating agent is disodium EDTA; the mask substrate is a bio-cellulose mask cloth; the bio-cellulose mask cloth has a thickness of 0.25 mm and a porosity of 83%.

[0050] A method for preparing the skin repair mask includes the following steps: Mixing the components of the mask liquid evenly according to their weight proportions, placing it in a vacuum degassing tank, and degassing it for 14 minutes under a vacuum of 0.065 MPa; after degassing, detecting the pH value of the mask liquid, adjusting the pH value to 6.3 to obtain the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape conforming to the facial contour, with each mask having an area of ​​24 cm², and evenly applying the mask liquid to the mask substrate, with each mask having a mask liquid loading of 29 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 24°C and the relative humidity at 55% during the packaging process; and storing the sealed mask in a low-temperature cold storage.

[0051] Example 5 A skin repair mask includes a mask base and a mask liquid attached to the mask base. The mask liquid, by weight, consists of the following components: 3.0 parts of liposome-encapsulated NMN, 2.0 parts of retinyl palmitate / ergothioneine complex nanocrystals, 15.0 parts of moisturizing and repairing components, 2.0 parts of soothing and anti-inflammatory components, 0.8 parts of thickener, 0.5 parts of preservative, 0.1 parts of chelating agent, 0.2 parts of fragrance, and deionized water to make up to 100 parts.

[0052] The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a 70°C constant temperature water bath, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 50 r / min and the water bath temperature at 55°C, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=7.0 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 20 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a 35°C water bath, and stirred for hydration for 40 min to obtain a crude liposome suspension; the crude liposome suspension is... The mixture was transferred to a high-pressure homogenizer, and homogenized twice at 800 bar pressure, with the homogenization temperature controlled at ≤30℃, to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, it was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant, and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ low-temperature freezer for 2 hours, and then transferred to a freeze dryer, with the freeze-drying temperature controlled at -35℃ and the vacuum degree at 30Pa, for 16 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained. The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol was 7:1:40:2:7.

[0053] The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: First, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a 40°C water bath for 15 minutes at a stirring speed of 800 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 12 minutes at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; the oil phase solution is slowly added dropwise to the aqueous phase solution at a dropping rate of 2 mL / min, while maintaining stirring at room temperature during the dropping process, and increasing the stirring speed to 1500 r / min; after the dropping is completed, stirring is continued for 20 minutes to obtain a homogeneous and fine pre-emulsion; the above pre-emulsion is transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads are added; the milling speed is adjusted to 2800 r / min. The grinding time was 50 minutes. During the grinding process, a circulating water bath was used for temperature control, and the temperature of the grinding system was strictly controlled at 30℃. The grinding equipment was kept in the dark throughout the process. After grinding, the grinding liquid was removed and vacuum filtered through a 0.45μm cosmetic-grade filter membrane to remove large, unevenly ground impurities and residual zirconia bead fragments, resulting in a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried into retinyl palmitate / ergothioneine complex nanocrystals using freeze-drying technology. The cosmetic-grade zirconia beads had a particle size of 0.2mm, and the volume ratio of zirconia beads to pre-emulsion was 2:1. The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water was 1.0:0.5:3.0:0.3:0.6:1.5:1.2:90.

[0054] The moisturizing and repairing components, by weight, consist of the following: 8.0 parts glycerin, 0.5 parts sodium hyaluronate, 3.0 parts panthenol, 2.0 parts hydrolyzed collagen, and 0.5 parts ceramide NP. The soothing and anti-inflammatory components, by weight, consist of the following: 0.5 parts Centella asiatica extract, 0.3 parts dipotassium glycyrrhizate, and 0.2 parts Myrtle extract. The Centella asiatica extract is provided by Changsha Hepu Biotechnology Co., Ltd., with a total saponin content of 80%. The Myrtle extract is provided by Xi'an Jincuifang Plant Technology Development Co., Ltd., under the brand name Jincuifang.

[0055] The preservative is potassium sorbate; the thickener is carbomer 940; the chelating agent is EDTA-disodium; the mask substrate is a bio-cellulose mask cloth; the bio-cellulose mask cloth has a thickness of 0.3 mm and a porosity of 85%.

[0056] A method for preparing the skin repair mask includes the following steps: Mixing the components of the mask liquid evenly according to their weight proportions, placing it in a vacuum degassing tank, and degassing for 15 minutes under a vacuum of 0.07 MPa; after degassing, detecting the pH value of the mask liquid, adjusting the pH value to 6.5 to obtain the mask liquid; selecting a bio-cellulose mask sheet, cutting it into a shape conforming to the facial contour, with each mask having an area of ​​25 cm², and evenly applying the mask liquid to the mask substrate, with each mask having a mask liquid loading of 30 g; placing the mask substrate loaded with the mask liquid into a sterile aluminum foil bag, sealing it, and controlling the ambient temperature at 25°C and the relative humidity at 60% during the packaging process; storing the sealed mask in a low-temperature cold storage.

[0057] Comparative Example 1 This example provides a skin repair mask and its preparation method, which is basically the same as in Example 5, except that free NMN is used instead of liposomes to encapsulate NMN (the amount of NMN is the same).

[0058] Comparative Example 2 This example provides a skin repair mask and its preparation method, which is basically the same as in Example 5, except that a retinyl palmitate / ergothioneine complex is used instead of retinyl palmitate / ergothioneine complex nanocrystals (the amounts of retinyl palmitate and ergothioneine are the same).

[0059] Comparative Example 3 This example provides a skin repair mask and its preparation method, which is basically the same as that in Example 5, except that an equal amount of NMN is encapsulated in liposomes instead of retinyl palmitate / ergothioneine complex nanocrystals.

[0060] Comparative Example 4 This example provides a skin repair mask and its preparation method, which is basically the same as that in Example 5, except that an equal amount of retinyl palmitate / ergothioneine complex nanocrystals are used instead of liposomes to encapsulate NMN.

[0061] Comparative Example 5 This example provides a skin repair mask and its preparation method, which is basically the same as Example 5. The difference is that the skin repair composition in Example 1 of the invention patent document CN116869858A is freeze-dried at -35°C instead of liposome-encapsulated NMN (where the amount of NMN is the same).

[0062] Comparative Example 6 This example provides a skin repair mask and its preparation method, which is basically the same as in Example 5, except that an equal amount of Centella asiatica extract is used instead of Myrtle extract.

[0063] Comparative Example 7 This example provides a skin repair mask and its preparation method, which is basically the same as in Example 5, except that an equal amount of myrtle extract is used instead of centella asiatica extract.

[0064] Allergy test: 400 patients with cosmetic-sensitive skin diseases were randomly divided into 8 groups, labeled as Example 5 group and Comparative Examples 1-7, with 50 people per group. Samples prepared in Example 5 and Comparative Examples 1-7 were applied to the upper back of the subjects using non-irritating adhesive tape. After 48 hours, the adhesive tape was removed, and the test results were observed. No obvious changes in the skin were observed (no allergic reactions such as erythema, edema, papules, or itching). It can be seen that the products of the present invention and the comparative examples have good anti-allergy effects and are suitable for people with sensitive skin.

[0065] Skin Repair Efficacy Test: 400 women aged 20-50 years with facial skin redness, itching, and other allergic symptoms were randomly divided into 8 groups, designated as Example 5 and Comparative Examples 1-7, with 50 participants per group. Each group used the prepared mask after cleansing morning and evening, applying it for 10 minutes, then removing the mask and washing their face. This was repeated for 14 consecutive days. During the trial period, participants avoided consuming irritating foods and using other cosmetics. The efficacy was evaluated during the trial period, and the criteria for efficacy judgment are as follows: Cured: After use, the redness and itching of the skin completely disappeared, and there was no recurrence after 7 days of continuous observation; Significant effect: Symptoms are significantly reduced after use; Ineffective: Symptoms do not improve or may worsen after use.

[0066] Note: Overall effectiveness rate = (number of cured patients + number of patients with significant improvement) / total number of test subjects × 100%; test results are shown in Table 1.

[0067] As can be seen from the data in Table 1, the cure rate (100.0%) and total effective rate (100.0%) of the product in Example 5 of this invention are significantly higher than those of the comparative examples. This confirms the technical advantages of the dual-core active components (liposome-encapsulated NMN + retinyl palmitate / ergothioneine complex nanocrystals) and the compound synergistic effect of the soothing and anti-inflammatory components (Centella asiatica extract + Myrtle extract + dipotassium glycyrrhizate) of this invention. It also highlights the necessity of liposome encapsulation technology and nanocrystal delivery technology, as well as the positive effect of the synergistic enhancement of Myrtle extract with the original components, which is not disclosed in the prior art.

[0068] Table 1 Group Heal (person) Effective (person) Invalid (person) Cure rate (%) Overall effectiveness (%) Example 5 50 0 0 100.0 100.0 Comparative Example 1 28 13 9 56.0 82.0 Comparative Example 2 26 14 10 52.0 80.0 Comparative Example 3 30 12 8 60.0 84.0 Comparative Example 4 29 12 9 58.0 82.0 Comparative Example 5 31 11 8 62.0 84.0 Comparative Example 6 35 10 5 70.0 90.0 Comparative Example 7 34 11 5 68.0 90.0 The above embodiments are only for illustrating the technical concept and features of the present invention. Their purpose is to enable those skilled in the art to understand the content of the present invention and implement it accordingly. They should not be used to limit the scope of protection of the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A skin repair mask, characterized in that, The product includes a mask base material and a mask liquid adhered to the mask base material. The mask liquid, by weight, consists of the following components: 0.5-3.0 parts of liposome-encapsulated NMN, 0.3-2.0 parts of retinyl palmitate / ergothioneine complex nanocrystals, 5.0-15.0 parts of moisturizing and repairing components, 0.1-2.0 parts of soothing and anti-inflammatory components, 0.1-0.8 parts of thickener, 0.1-0.5 parts of preservative, 0.01-0.1 parts of chelating agent, 0.01-0.2 parts of fragrance, and deionized water to make up to 100 parts.

2. The skin repair mask according to claim 1, characterized in that, The method for preparing NMN encapsulated in liposomes includes the following steps: Lecithin and cholesterol are added to anhydrous ethanol and placed in a constant temperature water bath at 60-70℃, stirred to obtain a homogeneous and transparent lipid organic solution; the solution is transferred to a rotary evaporator, and the rotation speed is controlled at 30-50 r / min and the water bath temperature at 45-55℃, and the anhydrous ethanol is slowly removed by rotary evaporation until a uniform and dense blank liposome film is formed on the inner wall of the container; a phosphate buffer solution with pH=6.0-7.0 is prepared, and NMN is dissolved in the buffer solution to prepare an NMN buffer solution with a concentration of 10-20 mg / mL; the NMN buffer solution is slowly added to the prepared blank liposome film, placed in a water bath at 30-35℃, and stirred for hydration for 30-40 minutes. The crude liposome suspension was obtained by homogenizing for 1-2 times at a pressure of 600-800 bar. The homogenized liposome suspension was then transferred to a high-pressure homogenizer and homogenized at a temperature ≤30℃ to obtain a liposome-encapsulated NMN suspension with uniform particle size and good dispersibility. After homogenization, the suspension was filtered through a 0.22μm microporous membrane to remove impurities and large agglomerates. Mannitol was added to the filtered liposome-encapsulated NMN suspension as a freeze-drying protectant and stirred until completely dissolved. The mixture was pre-frozen in a -40℃ freezer for 2 hours and then transferred to a freeze dryer. The freeze-drying temperature was controlled at -25℃ to -35℃ and the vacuum degree was 10-30Pa. The mixture was freeze-dried for 12-16 hours until a loose, easily resoluble powdered liposome-encapsulated NMN product was obtained.

3. The skin repair mask according to claim 2, characterized in that, The mass ratio of lecithin, cholesterol, anhydrous ethanol, NMN, and mannitol is (5-7):1:(30-40):(0.5-2):(2.5-7).

4. The skin repair mask according to claim 1, characterized in that, The preparation method of the retinyl palmitate / ergothioneine complex nanocrystals includes the following steps: first, retinyl palmitate and vitamin E are added to polyethylene glycol-400 and stirred in a water bath at 35-40℃ for 10-15 min at a stirring speed of 500-800 r / min until completely dissolved to obtain an oil phase solution; simultaneously, ergothioneine, panthenol, Tween 80, and lecithin are added to deionized water and stirred at room temperature for 8-12 min at a stirring speed of 600 r / min until completely dissolved to obtain an aqueous phase solution; The oil phase solution was slowly added dropwise to the aqueous phase solution at a rate of 1-2 mL / min. During the addition process, the mixture was stirred at room temperature and the stirring speed was increased to 1200-1500 r / min. After the addition was completed, the mixture was stirred for another 20 min to obtain a homogeneous and fine pre-emulsion. The pre-emulsion was transferred to a cosmetic-grade wet milling apparatus, and cosmetic-grade zirconia beads were added. The milling speed was adjusted to 2200-2800 r / min, and the milling time was 40-50 min. During the milling process, a circulating water bath was used to control the temperature, and the temperature of the milling system was strictly controlled at 25-30℃. At the same time, the milling equipment was kept away from light throughout the process. After milling, the milling liquid was removed and vacuum filtered using a 0.45μm cosmetic-grade filter membrane to remove large particles of impurities that were not milled evenly and a small amount of residual zirconia bead debris, so as to obtain a uniform and transparent retinyl palmitate / ergothioneine complex nanocrystal suspension. Finally, the suspension was dried into retinyl palmitate / ergothioneine complex nanocrystals using freeze-drying technology.

5. The skin repair mask according to claim 4, characterized in that, The mass ratio of retinyl palmitate, vitamin E, polyethylene glycol-400, ergothioneine, panthenol, Tween 80, lecithin, and deionized water is as follows: (0.5-1.0):(0.2-0.5):(2.0-3.0):(0.1-0.3):(0.3-0.6):(1.0-1.5):(0.8-1.2):(85-90); The cosmetic-grade zirconia beads have a particle size of 0.2 mm, and the volume ratio of zirconia beads to pre-emulsion is 2:

1.

6. The skin repair mask according to claim 1, characterized in that, The moisturizing and repairing components, by weight, consist of the following components: 3.0-8.0 parts glycerin, 0.1-0.5 parts sodium hyaluronate, 1.0-3.0 parts panthenol, 0.5-2.0 parts hydrolyzed collagen, and 0.1-0.5 parts ceramide NP.

7. The skin repair mask according to claim 1, characterized in that, The soothing and anti-inflammatory component is composed of the following components by weight: 0.05-0.5 parts of Centella asiatica extract, 0.03-0.3 parts of dipotassium glycyrrhizate, and 0.02-0.2 parts of Myrtle extract.

8. The skin repair mask according to claim 1, characterized in that, The preservative is at least one of sorbic acid and potassium sorbate; the thickener is at least one of carbomer 940 and sodium carboxymethyl cellulose.

9. The skin repair mask according to claim 1, characterized in that, The chelating agent is EDTA-disodium; the mask substrate is a bio-cellulose mask fabric; the bio-cellulose mask fabric has a thickness of 0.1-0.3 mm and a porosity of 70%-85%.

10. A method for preparing a skin repair mask according to any one of claims 1-9, characterized in that, The process includes the following steps: Mix all components of the mask liquid evenly according to their weight proportions, place the mixture in a vacuum degassing tank, and degas for 10-15 minutes under a vacuum of 0.05-0.07 MPa; after degassing, test the pH value of the mask liquid and adjust it to 5.5-6.5 to obtain the mask liquid; select a bio-cellulose mask sheet, cut it into a shape that conforms to the facial contours, with each mask having an area of ​​20-25 cm², and evenly apply the mask liquid onto the mask substrate, with each mask having a liquid load of 25-30 g; pack the liquid-loaded mask substrate into a sterile aluminum foil bag, seal it, and control the ambient temperature at 20-25℃ and the relative humidity at 40%-60% during the packaging process; store the sealed mask in a low-temperature cold storage.