Lactic acid metabolism regulation nano preparation, preparation method and application

By using a lactate metabolism-regulating nano-formulation, and utilizing oxygen-enriched phase change agents and GLUT1 inhibitors, the problem of excessive lactate production during HIFU treatment was solved. This achieved source blocking of lactate production within the tumor and reversal of immunosuppression, thereby improving the tumor ablation effect.

CN122005791APending Publication Date: 2026-05-12THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202610240076.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-28
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

In the treatment of hepatocellular carcinoma with high-intensity focused ultrasound, insufficient energy deposition in the target area leads to the production of large amounts of lactate, forming a sublethal heat stress zone, which weakens effector T cell proliferation and promotes an immunosuppressive microenvironment, increasing the risk of recurrence. Furthermore, existing lactate metabolism intervention strategies cannot effectively block lactate production in tumor cells.

Method used

The lactate metabolism regulating nano-formulation uses liposomes containing oxygen-enriched phase change agents and cRGD peptides to generate microbubbles through ultrasound-triggered phase change, which enhances the local sound field, reduces HIFU output power, releases oxygen to improve tumor oxygenation, and is combined with GLUT1 inhibitors to block glucose uptake, inhibiting lactate production from multiple levels.

Benefits of technology

It significantly reduces lactate production, improves the tumor microenvironment, enhances tumor ablation efficacy, reverses immunosuppression, increases tumor oxygenation levels, reduces the power required for HIFU ablation, reduces heat-induced lactate production, and enhances tumor necrosis.

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Abstract

The invention relates to the field of biological medicine, in particular to a lactic acid metabolism regulation nano preparation, a preparation method and application thereof.The lactic acid metabolism regulation nano preparation contains an oxygen-enriched phase change agent, the oxygen-enriched phase change agent serves as a core, the outer side of the oxygen-enriched phase change agent is wrapped with lipidosome, the lipidosome is cRGD peptide modified lipidosome, the lipidosome is loaded with a GLUT-1 inhibitor, the GLUT-1 inhibitor is BAY-876, and the oxygen-enriched phase change agent serves as the core. The oxygen-enriched phase change agent is perfluorohexane. After the HIFU operation, the nano preparation can regulate lactic acid and reduce the generation of lactic acid, so that the problems that cells in a sublethal heat stress area undergo metabolic disorder and a large amount of lactic acid is generated after the HIFU operation are solved.
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