Medical bacteriostatic and anti-inflammatory sodium hyaluronate dressing and preparation method thereof

Abstract

The invention belongs to the technical field of dressings, and particularly relates to a medical bacteriostatic and anti-inflammatory sodium hyaluronate dressing and a preparation method thereof. The sodium hyaluronate dressing is prepared from the following raw materials in percentage by mass: 3 to 5 percent of sodium hyaluronate, 1.5 to 3 percent of polyvinyl alcohol, 1.5 to 2 percent of modified silicon nitride, 0.3 to 0.5 percent of fructus tsaoko extract, 0.4 to 0.7 percent of carbomer, 1 to 2 percent of sodium alginate and the balance of deionized water. The dressing can effectively improve the bacteriostatic and anti-inflammatory effects of the dressing, prevent wound infection and promote wound healing.

Description

Technical Field

[0001] This invention belongs to the field of dressing technology, specifically relating to a medical antibacterial and anti-inflammatory sodium hyaluronate dressing and its preparation method. Background Technology

[0002] Wound management is a core aspect of clinical medicine and daily care. Ideal wound dressings not only passively cover the wound but also actively create a microenvironment conducive to healing, effectively resisting infection and accelerating tissue repair. Traditional dressings, such as gauze, are no longer sufficient to meet the demands of modern medicine for efficient healing due to their tendency to adhere to newly formed granulation tissue, causing secondary damage during dressing changes, and poor moisture retention. Therefore, developing novel functional dressings that combine excellent biological functions with a pleasant user experience has become a research hotspot in the field of biomaterials.

[0003] Among numerous biomaterials, sodium hyaluronate is highly favored due to its excellent biocompatibility and moisturizing properties. It is an important component of the human extracellular matrix, significantly regulating wound moisture, promoting cell migration and proliferation, and thus accelerating wound healing. However, sodium hyaluronate gel alone suffers from insufficient mechanical properties, such as low mechanical strength, easy degradation, and poor moldability, making it difficult to use alone as a dressing, and it lacks significant antibacterial ability. Excessive swelling caused by wound exudate accumulation may even lead to gel structure collapse, providing a breeding ground for bacteria. Therefore, a composite modification strategy that enhances the mechanical strength and endows sodium hyaluronate with strong antibacterial capabilities while retaining its healing-promoting advantages is key to overcoming its application bottlenecks. Based on this, this invention provides a medical antibacterial and anti-inflammatory sodium hyaluronate dressing. Summary of the Invention

[0004] In order to overcome the shortcomings of the prior art, the first objective of the present invention is to provide a medical antibacterial and anti-inflammatory sodium hyaluronate dressing with excellent antibacterial, mechanical and wound-healing properties.

[0005] The second objective of this invention is to provide a simple method for preparing a medical antibacterial and anti-inflammatory sodium hyaluronate dressing.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: A medical antibacterial and anti-inflammatory sodium hyaluronate dressing, by weight percentage, is composed of the following raw materials: 3-5% sodium hyaluronate, 1.5-3% polyvinyl alcohol, 1.5-2% modified silicon nitride, 0.3-0.5% Tetrapanax papyriferus fruit extract, 0.4-0.7% carbomer, 1-2% sodium alginate, and the balance being deionized water; The preparation process of the modified silicon nitride is as follows: (a) After activating the silicon nitride particles, add them to an aqueous ethanol solution, then add γ-glycidyl etheroxypropyltrimethoxysilane, heat to react, and after the reaction is complete, filter, wash and dry to obtain pretreated silicon nitride particles. (b) Take the pretreated silicon nitride particles and L-tyrosine methyl ester from step (a) and add them to an aqueous ethanol solution. Stir the reaction and after the reaction is complete, filter and dry the product. (c) The product of step (b) is added to N,N-dimethylformamide, then itaconic anhydride and potassium carbonate are added and heated. After the reaction is completed, the mixture is filtered, washed and dried to obtain the modified silicon nitride.

[0007] Silicon nitride particles possess good biocompatibility and antibacterial activity; however, they tend to aggregate in dressings, and their hydrophobic surface affects their effectiveness. Therefore, this invention first modifies silicon nitride particles with a silane coupling agent, introducing epoxy groups onto their surface. Then, the epoxy groups react with the amino groups on L-tyrosine methyl ester, which has good bioactivity, reducing wound irritation and preventing exacerbation of inflammation. Unreacted amino or phenolic hydroxyl groups on the L-tyrosine methyl ester react with itaconic anhydride, and the itaconic anhydride and silicon nitride particles work synergistically to exert antibacterial properties. The modified silicon nitride surface has abundant polar groups such as carboxyl and phenolic hydroxyl groups, exhibiting good hydrophilicity, rapidly absorbing exudate, increasing the swelling ratio of the dressing, and promoting cell proliferation and accelerating wound healing and skin tissue repair through the interaction of active groups and cell surface receptors. During the preparation of the dressing, the active groups such as carboxyl groups and phenolic hydroxyl groups on the surface of the modified silicon nitride can interact with sodium hyaluronate, polyvinyl alcohol, etc. through hydrogen bonds and ionic bonds to form a stable three-dimensional network structure, which further improves the mechanical properties of the dressing.

[0008] Furthermore, in step (a), the mass ratio of silicon nitride particles, γ-glycidoxypropyltrimethoxysilane, and ethanol aqueous solution is 1:(0.3-0.5):(12-16); the concentration of the ethanol aqueous solution is 85-90 wt%.

[0009] Furthermore, the volumetric particle size Dv50 of the silicon nitride particles is 500-1000 nm.

[0010] Furthermore, the activation treatment in step (a) is carried out at a temperature of 120-130°C for 2-3 hours; the heating reaction is carried out at a temperature of 60-70°C for 6-8 hours.

[0011] Furthermore, in step (b), the mass ratio of the pretreated silicon nitride particles, L-tyrosine methyl ester, and ethanol aqueous solution is 1:(2-3):(32-36); the concentration of the ethanol aqueous solution is 50wt%.

[0012] Furthermore, the temperature of the stirring reaction in step (b) is 40-50°C, and the time is 8-12 hours.

[0013] Furthermore, in step (c), the mass ratio of the product, itaconic anhydride, and potassium carbonate is 1:(1-1.15):(1.8-2); the heating temperature is 50-60℃, and the heating time is 3-5h.

[0014] Furthermore, the sodium hyaluronate has a molecular weight of 10-30 kDa; the polyvinyl alcohol is polyvinyl alcohol 1788, with a molecular weight of 75-80 kDa, a degree of polymerization of 1700, and a degree of alcoholysis of 87-89%.

[0015] The preparation method of the above-mentioned medical antibacterial and anti-inflammatory sodium hyaluronate dressing includes the following steps: S1: Weigh each raw material according to the stated mass percentage, add carbomer to half of the deionized water, mix well, and obtain a carbomer solution. S2: Add modified silicon nitride, Tetrapanax papyriferus fruit extract, sodium hyaluronate, sodium alginate, and polyvinyl alcohol to the remaining deionized water, mix well, and obtain a mixed solution; S3: Add the carbomer solution of S1 to the mixed solution of S2, stir well, and then irradiate.

[0016] Furthermore, the irradiation time is 5-8 minutes.

[0017] Compared with the prior art, the main advantages of the present invention are as follows: This invention provides a medical antibacterial and anti-inflammatory sodium hyaluronate dressing. The addition of sodium hyaluronate, modified silicon nitride, and extracts from *Tetrapanax papyriferus* fruit, among other ingredients, effectively improves the dressing's antibacterial and anti-inflammatory effects, prevents wound infection, and promotes wound healing. Specifically, silicon nitride particles are first modified with a silane coupling agent to introduce epoxy groups onto their surface. The epoxy groups then react with the amino groups on L-tyrosine methyl ester, which has good biological activity. This reduces the dressing's irritation to the wound and prevents exacerbation of inflammation. Unreacted amino or phenolic hydroxyl groups on the L-tyrosine methyl ester react with itaconic anhydride, and the itaconic anhydride and silicon nitride particles work synergistically to exert antibacterial properties. The modified silicon nitride surface has abundant polar groups such as carboxyl and phenolic hydroxyl groups, exhibiting good hydrophilicity. It can quickly absorb exudate, increasing the dressing's swelling ratio. Furthermore, through the interaction of active groups and cell surface receptors, it promotes cell proliferation and accelerates wound healing and skin tissue repair. During the preparation of the dressing, the active groups such as carboxyl groups and phenolic hydroxyl groups on the surface of the modified silicon nitride can interact with sodium hyaluronate, polyvinyl alcohol, etc. through hydrogen bonds and ionic bonds to form a stable three-dimensional network structure, which further improves the mechanical properties of the dressing. Attached Figure Description

[0018] Figure 1 This is a SEM image of the modified silicon nitride obtained in Example 1. Detailed Implementation

[0019] The technical solution of the present invention will be further described below with reference to specific embodiments. However, those skilled in the art should understand that the following embodiments are only for illustrating the present invention and should not be regarded as limiting the present invention. Specific conditions not specified in the embodiments are performed according to conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the reagents or instruments used are all conventional products obtained through commercial channels.

[0020] The polyvinyl alcohol involved in this invention is polyvinyl alcohol 1788, with a molecular weight of 75-80 kDa, a degree of polymerization of 1700, and a degree of alcoholysis of 87-89%.

[0021] The preparation method of the extract of Tetrapanax papyriferus fruit in this invention is as follows: After cleaning the fruit of Tetrapanax papyriferus, the pulp is extracted, crushed, dried and concentrated to obtain pulp pulp. The pulp pulp is mixed with anhydrous ethanol at a volume ratio of 1:3, and then the pH is adjusted to 3 with citric acid. After stirring evenly, it is centrifuged and dried to obtain Tetrapanax papyriferus extract.

[0022] Preparation Example 1 A modified silicon nitride, prepared as follows: (a) With silicon nitride particles, γ-glycidoxypropyltrimethoxysilane and ethanol aqueous solution in a mass ratio of 1:0.4:14, silicon nitride particles (Dv50=1000nm) were activated at 125℃ for 2.5h, then added to an 88wt% ethanol aqueous solution, followed by the addition of γ-glycidoxypropyltrimethoxysilane, and reacted at 65℃ for 7h. After the reaction was completed, the particles were filtered, washed and dried to obtain pretreated silicon nitride particles. (b) The pretreated silicon nitride particles, L-tyrosine methyl ester and ethanol aqueous solution were added to a 50 wt% ethanol aqueous solution at a mass ratio of 1:2.5:35. The reaction was carried out at 45 °C for 10 h. After the reaction was completed, the product was filtered, dried and collected. (c) The product from step (b) was added to N,N-dimethylformamide (DMF) at a mass ratio of product, itaconic anhydride, and potassium carbonate of 1:1.12:1.9. Itaconic anhydride and potassium carbonate were then added, and the mixture was reacted at 55°C for 4 hours. After the reaction was complete, the mixture was filtered, washed, and dried to obtain the modified silicon nitride. The SEM image of the modified silicon nitride is shown below. Figure 1 .

[0023] Preparation Example 2 A modified silicon nitride, prepared as follows: (a) With silicon nitride particles, γ-glycidoxypropyltrimethoxysilane and ethanol aqueous solution in a mass ratio of 1:0.3:12, silicon nitride particles (Dv50=500nm) were activated at 120℃ for 3h, then added to an 85wt% ethanol aqueous solution, followed by the addition of γ-glycidoxypropyltrimethoxysilane, and reacted at 60℃ for 8h. After the reaction was completed, the particles were filtered, washed and dried to obtain pretreated silicon nitride particles. (b) The pretreated silicon nitride particles, L-tyrosine methyl ester and ethanol aqueous solution were added to a 50 wt% ethanol aqueous solution at a mass ratio of 1:2:32. The reaction was carried out at 40 °C for 12 h. After the reaction was completed, the product was filtered, dried and collected. (c) The product from step (b) was added to DMF in a mass ratio of product, itaconic anhydride and potassium carbonate of 1:1:1.8. Itaconic anhydride and potassium carbonate were then added and reacted at 50°C for 5 hours. After the reaction was completed, the product was filtered, washed and dried to obtain the modified silicon nitride.

[0024] Preparation Example 3 A modified silicon nitride, prepared as follows: (a) With silicon nitride particles, γ-glycidoxypropyltrimethoxysilane and ethanol aqueous solution in a mass ratio of 1:0.5:16, silicon nitride particles (Dv50=800nm) were activated at 130℃ for 2h, then added to 90wt% ethanol aqueous solution, followed by γ-glycidoxypropyltrimethoxysilane, and reacted at 70℃ for 6h. After the reaction was completed, the particles were filtered, washed and dried to obtain pretreated silicon nitride particles. (b) The pretreated silicon nitride particles, L-tyrosine methyl ester and ethanol aqueous solution were added to a 50 wt% ethanol aqueous solution at a mass ratio of 1:3:36. The reaction was carried out at 50 °C for 8 h. After the reaction was completed, the product was filtered, dried and collected. (c) The product from step (b) was added to DMF in a mass ratio of product, itaconic anhydride and potassium carbonate of 1:1.15:2. Itaconic anhydride and potassium carbonate were then added and reacted at 60°C for 3 hours. After the reaction was completed, the product was filtered, washed and dried to obtain the modified silicon nitride.

[0025] Example 1 A medical antibacterial and anti-inflammatory sodium hyaluronate dressing, by weight percentage, is composed of the following raw materials: 4% sodium hyaluronate (20kDa), 2% polyvinyl alcohol, 1.8% modified silicon nitride of Preparation Example 1, 0.4% Tetrapanax papyriferus fruit extract, 0.6% carbomer, 1.5% sodium alginate, and the balance being deionized water.

[0026] The preparation method of the above-mentioned medical antibacterial and anti-inflammatory sodium hyaluronate dressing includes the following steps: S1: Weigh each raw material according to the stated mass percentage, add carbomer to half of the deionized water, mix well, and obtain a carbomer solution. S2: Add modified silicon nitride, Tetrapanax papyriferus fruit extract, sodium hyaluronate, sodium alginate, and polyvinyl alcohol to the remaining deionized water, mix well, and obtain a mixed solution; S3: Add the carbomer solution of S1 to the mixed solution of S2, stir well, and then irradiate under a 400W ultraviolet lamp for 6 minutes.

[0027] Example 2 A medical antibacterial and anti-inflammatory sodium hyaluronate dressing, by weight percentage, is composed of the following raw materials: 3% sodium hyaluronate (10kDa), 1.5% polyvinyl alcohol, 1.5% modified silicon nitride of Preparation Example 2, 0.3% Tetrapanax papyriferus fruit extract, 0.4% carbomer, 1% sodium alginate, and the balance being deionized water.

[0028] The preparation method of the above-mentioned medical antibacterial and anti-inflammatory sodium hyaluronate dressing includes the following steps: S1: Weigh each raw material according to the stated mass percentage, add carbomer to half of the deionized water, mix well, and obtain a carbomer solution. S2: Add modified silicon nitride, Tetrapanax papyriferus fruit extract, sodium hyaluronate, sodium alginate, and polyvinyl alcohol to the remaining deionized water, mix well, and obtain a mixed solution; S3: Add the carbomer solution of S1 to the mixed solution of S2, stir well, and then irradiate under a 400W ultraviolet lamp for 5 minutes.

[0029] Example 3 A medical antibacterial and anti-inflammatory sodium hyaluronate dressing, by weight percentage, is composed of the following raw materials: 5% sodium hyaluronate (30kDa), 3% polyvinyl alcohol, 2% modified silicon nitride of Preparation Example 3, 0.5% Tetrapanax papyriferus fruit extract, 0.7% carbomer, 2% sodium alginate, and the balance being deionized water.

[0030] The preparation method of the above-mentioned medical antibacterial and anti-inflammatory sodium hyaluronate dressing includes the following steps: S1: Weigh each raw material according to the stated mass percentage, add carbomer to half of the deionized water, mix well, and obtain a carbomer solution. S2: Add modified silicon nitride, Tetrapanax papyriferus fruit extract, sodium hyaluronate, sodium alginate, and polyvinyl alcohol to the remaining deionized water, mix well, and obtain a mixed solution; S3: Add the carbomer solution of S1 to the mixed solution of S2, stir well, and then irradiate under a 400W ultraviolet lamp for 8 minutes.

[0031] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that silicon nitride was used instead of the modified silicon nitride used in Example 1, while the rest remained the same as in Example 1.

[0032] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the extract of Tetrapanax papyriferus fruit was omitted, while the rest remained the same as in Example 1.

[0033] Experimental Example 1 The mechanical properties, swelling properties, and antibacterial properties of the dressings obtained in Examples 1-3 and Comparative Examples 1-2 were tested. The specific testing methods are as follows: 1.1 Swelling properties The dressing samples obtained in Examples 1-3 and Comparative Examples 1-2 were dried to constant weight in a vacuum freeze dryer, cut into test samples with a length of 40 mm, a width of 4 mm, and a thickness of 2 mm, and weighed, denoted as M0. Each test sample was immersed in deionized water, and after periodic intervals, it was removed, the surface moisture was wiped off, and the weight was recorded as M. t Calculate the swelling ratio SR. SR = (M t -M0) / M0×100%, the results are shown in Table 1.

[0034] 1.2 Mechanical Properties The dressing samples obtained in Examples 1-3 and Comparative Examples 1-2 were dried to constant weight in a vacuum freeze dryer and cut into test samples with a length of 40 mm, a width of 4 mm, and a thickness of 2 mm. The tensile strength and elongation at break of the dressings were tested using a universal testing machine. The dressings were stretched at a constant strain rate of 100 mm / min, and the tensile strength and elongation at break of each test sample were measured. The results are shown in Table 1.

[0035] 1.3 Antibacterial properties Activated Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were inoculated onto agar plates (ordinary broth medium) and incubated at 37°C for 24 hours, after which the bacterial cells were diluted to 1×10⁻⁶. 8 CFU / mL, then add 0.1g of the medical dressings obtained in Examples 1-3 and Comparative Examples 1-2, incubate at room temperature for 1h, then take 50μL of each and spread it on a plate. Incubate upside down at 37℃ for 24h, observe the colony growth and count the number of colonies. The control group is sterile water. The results are shown in Table 2.

[0036] Table 1 Table 2 As shown in Table 1, compared to Comparative Example 1, the dressing obtained in Example 1 exhibits higher mechanical properties and a higher swelling ratio. These results indicate that the addition of modified silicon nitride significantly improves the mechanical properties and swelling ratio of the dressing. This is because the modified silicon nitride surface possesses abundant polar groups such as carboxyl and phenolic hydroxyl groups, exhibiting good hydrophilicity and rapid absorption of exudate, thus increasing the swelling ratio of the dressing. Furthermore, during the dressing preparation process, the active groups such as carboxyl and phenolic hydroxyl groups on the modified silicon nitride surface can interact with sodium hyaluronate, polyvinyl alcohol, etc., through hydrogen bonds and ionic bonds to form a stable three-dimensional network structure, further improving the mechanical properties of the dressing.

[0037] As shown in Table 2, compared with Comparative Examples 1-2, the dressing obtained in Example 1 has excellent antibacterial and anti-inflammatory effects. The above results indicate that the combined use of modified silicon nitride and Tetrapanax papyriferus fruit extract can effectively improve the antibacterial and anti-inflammatory effects of the dressing. Experimental Example 2 The wound healing promotion properties of the dressings obtained in Examples 1-3 and Comparative Examples 1-2 were tested, and the specific testing methods are as follows: 2.1 Laboratory Animals Forty male mice, each weighing 20-22g, were acclimatized and fed for one week.

[0038] 2.2 Experimental Procedure One week later, the mice were randomly divided into 5 groups: Example 1-3 groups and Comparative Example 1-2 groups, with 8 mice in each group. A skin defect model with a diameter of 10 mm was created on the back of each group of mice. The wound was treated with the dressing corresponding to the group, and the dressing was changed once a day. The area of ​​the remaining wound was recorded each day. The results are shown in Table 3.

[0039] Table 3 As shown in Table 3, compared with Comparative Examples 1-2, the dressing obtained in Example 1 can better promote wound healing. The above results indicate that the combined use of modified silicon nitride and Tetrapanax papyrifer extract can effectively promote wound healing. This is because the present invention first modifies silicon nitride particles with a silane coupling agent, introducing epoxy groups onto their surface. Then, the epoxy groups react with the amino groups on L-tyrosine methyl ester, which has good biological activity, reducing the dressing's irritation to the wound and preventing the aggravation of inflammatory reactions. Unreacted amino or phenolic hydroxyl groups on the L-tyrosine methyl ester react with itaconic anhydride, and itaconic acid and silicon nitride particles work synergistically to exert antibacterial properties. The modified silicon nitride can also promote cell proliferation and accelerate wound healing and skin tissue repair through the interaction of active groups and cell surface receptors. The combined use of modified silicon nitride and Tetrapanax papyrifer extract can effectively promote wound healing.

[0040] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them. The basic principles and main features of the present invention have been described above with specific implementation schemes. Based on the present invention, some modifications or substitutions can be made, but these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of protection claimed by the present invention.

Claims

1. A medical antibacterial and anti-inflammatory sodium hyaluronate dressing, characterized in that, By mass percentage, it is composed of the following raw materials: sodium hyaluronate 3-5%, polyvinyl alcohol 1.5-3%, modified silicon nitride 1.5-2%, Tetrapanax papyriferus fruit extract 0.3-0.5%, carbomer 0.4-0.7%, sodium alginate 1-2%, and the balance being deionized water; The preparation process of the modified silicon nitride is as follows: (a) After activating the silicon nitride particles, add them to an aqueous ethanol solution, then add γ-glycidyl etheroxypropyltrimethoxysilane, heat to react, and after the reaction is complete, filter, wash and dry to obtain pretreated silicon nitride particles. (b) Take the pretreated silicon nitride particles and L-tyrosine methyl ester from step (a) and add them to an aqueous ethanol solution. Stir the reaction and after the reaction is complete, filter and dry the product. (c) The product of step (b) is added to N,N-dimethylformamide, then itaconic anhydride and potassium carbonate are added and heated. After the reaction is completed, the mixture is filtered, washed and dried to obtain the modified silicon nitride.

2. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, The mass ratio of silicon nitride particles, γ-glycidoxypropyltrimethoxysilane, and aqueous ethanol solution in step (a) is 1:(0.3-0.5):(12-16); the concentration of the aqueous ethanol solution is 85-90 wt%.

3. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 2, characterized in that, The volumetric particle size Dv50 of silicon nitride particles is 500-1000 nm.

4. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, The activation treatment in step (a) is performed at a temperature of 120-130°C for 2-3 hours; the heating reaction is performed at a temperature of 60-70°C for 6-8 hours.

5. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, In step (b), the mass ratio of the pretreated silicon nitride particles, L-tyrosine methyl ester, and ethanol aqueous solution is 1:(2-3):(32-36); the concentration of the ethanol aqueous solution is 50wt%.

6. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, The stirring reaction in step (b) is carried out at a temperature of 40-50°C for 8-12 hours.

7. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, In step (c), the mass ratio of the product, itaconic anhydride, and potassium carbonate is 1:(1-1.15):(1.8-2); the heating temperature is 50-60℃ and the heating time is 3-5h.

8. The medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 1, characterized in that, The sodium hyaluronate has a molecular weight of 10-30 kDa; the polyvinyl alcohol is polyvinyl alcohol 1788, with a molecular weight of 75-80 kDa, a degree of polymerization of 1700, and a degree of alcoholysis of 87-89%.

9. A method for preparing a medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to any one of claims 1-8, characterized in that, Includes the following steps: S1: Weigh each raw material according to the stated mass percentage, add carbomer to half of the deionized water, mix well, and obtain a carbomer solution. S2: Add modified silicon nitride, Tetrapanax papyriferus fruit extract, sodium hyaluronate, sodium alginate, and polyvinyl alcohol to the remaining deionized water, mix well, and obtain a mixed solution; S3: Add the carbomer solution of S1 to the mixed solution of S2, stir well, and then irradiate.

10. The method for preparing the medical antibacterial and anti-inflammatory sodium hyaluronate dressing according to claim 9, characterized in that, The irradiation time is 5-8 minutes.

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