Nucleic acid aptamer specifically combined with MMLV as well as preparation method and application of nucleic acid aptamer

By using SELEX technology to screen nucleic acid aptamers that bind to MMLV protein with high affinity, the problem of lack of specific MMLV binding enzymes in existing technologies has been solved, enabling efficient enrichment and detection of MMLV protein and promoting the research and application of MMLV enzymes.

CN122012513APending Publication Date: 2026-05-12THE UNIVERSITY-TOWN HOSPITAL AFFILIATED TO CHONGQING MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202610365200.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-24
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

The lack of nucleic acid aptamers in the current technology that can bind to MMLV enzymes efficiently and specifically limits the research and application of MMLV enzymes.

Method used

SELEX technology was used to screen nucleic acid aptamers that specifically bind to MMLV. Through multiple rounds of screening and amplification, nucleic acid aptamers that can bind to MMLV protein with high affinity were prepared and applied to the enrichment, separation and detection of MMLV protein.

Benefits of technology

This technology enables efficient enrichment, separation, and detection of MMLV proteins, enhancing the research and application capabilities of MMLV enzymes.

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Abstract

The invention belongs to the technical field of bioengineering, and particularly relates to a nucleic acid aptamer specifically bound with MMLV, and the nucleotide sequence of the nucleic acid aptamer is as shown in SEQ ID NO.1 or SEQ ID NO.2; the nucleic acid aptamer capable of being specifically bound with MMLV is obtained through screening on the basis of the SELEX technology, has high affinity for MMLV protein, can be applied to MMLV protein enrichment reagents, MMLV protein separation reagents, MMLV protein detection reagents, test paper and biosensors, and facilitates identification and activity research of the MMLV protein.
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