Traditional Chinese medicine preparation for treating cervical vertebra and lumbar vertebra

Abstract

The invention discloses a traditional Chinese medicine preparation for treating cervical vertebra and lumbar vertebra, and belongs to the technical field of traditional Chinese medicine preparations. The preparation is prepared from rhizoma polygonati, zaocys dhumnade, pawpaw, ginseng (artificially planted for less than five years), peach kernel, kudzuvine root, fructo-oligosaccharide and malt essence according to specific parts by weight through compatibility, the principle of'taking both symptoms and root causes into consideration and treating dialectically 'in traditional Chinese medicine is followed, and all the components act synergistically to jointly achieve the effects of tonifying liver and kidney, promoting blood circulation to remove blood stasis, relaxing tendons, dredging collaterals, relieving pain and relieving swelling. The preparation is a medicine and food homologous formula, is safe and non-toxic, adopts a solid beverage dosage form, is convenient to take, good in taste, stable in effective components and high in bioavailability, can quickly relieve pain, stiffness, numbness and other symptoms caused by cervical vertebra and lumbar vertebra degenerative diseases and chronic strain, can regulate the body constitution and delay the progress of the diseases after being taken for a long time, and has a good application prospect. The clinical application value and the market prospect are obvious.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine pharmaceutical technology, and in particular to a traditional Chinese medicine preparation for treating cervical and lumbar spondylosis. Background Technology

[0002] Cervical and lumbar spine diseases are common and frequently occurring diseases in clinical practice, and their pathological basis is mainly a series of pathological changes caused by the degenerative changes of the intervertebral discs, such as segmental instability, loosening, herniation or prolapse of the nucleus pulposus, osteophyte formation, ligament hypertrophy, and secondary spinal stenosis. These changes irritate or compress adjacent nerve roots, spinal cord, vertebral arteries, and cervical sympathetic nerves. In addition, factors such as chronic strain, acute trauma, developmental spinal stenosis, and congenital spinal malformations and changes in physiological curvature can induce inflammatory reactions such as edema and congestion of the spinal nerve roots, which gradually lead to fibrosis and even degeneration. Ultimately, this results in clinical symptoms mainly characterized by pain, numbness, and limited mobility. In severe cases, it can lead to limb weakness, sensory abnormalities, and even affect bowel and bladder function, seriously reducing the patient's quality of life and ability to work, and placing a heavy burden on individuals, families, and society.

[0003] Currently, clinical treatments for cervical and lumbar spine diseases are mainly divided into two categories: Western medicine and traditional Chinese medicine. Western medicine treatments often involve surgery, traction, and oral medications. Surgical treatments are highly invasive, risky, and have a long recovery period, with a certain recurrence rate, causing significant damage to the patient's body. Traction only temporarily relieves symptoms and cannot fundamentally solve the problem. Oral medications are mostly anti-inflammatory analgesics and neurotrophic drugs, which can easily lead to drug resistance with long-term use and may have adverse effects on gastrointestinal, liver, and kidney function, resulting in significant side effects.

[0004] Traditional Chinese medicine (TCM) considers cervical and lumbar spine diseases to fall under the categories of "Bi syndrome," "low back pain," and "cervical Bi." Their pathogenesis is mainly related to external injuries, invasion of wind-cold-dampness pathogens, disharmony of Qi and blood, obstruction of meridians, and deficiency of liver and kidney. Clinically, they are often classified into wind-cold-dampness Bi type, Qi stagnation and blood stasis type, phlegm-dampness obstruction type, and liver and kidney deficiency type. Currently available oral TCM preparations are mainly in the form of decoctions, pills, and capsules. Decoctions suffer from inconvenience in administration, difficulty in carrying, bitter taste, and easy loss of active ingredients; pills and capsules have shortcomings such as slow disintegration, low absorption efficiency, and delayed onset of action, failing to meet the needs of modern patients for convenient, palatable, and fast-acting preparations. Furthermore, some existing TCM preparations for treating cervical and lumbar spine diseases have complex formulas and high material costs; some preparations lack specificity, showing significant differences in therapeutic effects for different types of cervical and lumbar spine diseases; and some preparations do not fully consider the homology of medicine and food, posing certain safety risks with long-term use. Solid beverages, as a convenient form of pharmaceutical preparation, offer advantages such as portability, ease of consumption, easily adjustable taste, high stability of active ingredients, and ease of storage, and have been widely used in the health product and pharmaceutical fields. Combining traditional Chinese medicine for treating cervical and lumbar spine diseases with solid beverage dosage forms can not only leverage the therapeutic effects of traditional Chinese medicine but also overcome the drawbacks of traditional Chinese medicine preparations, thereby improving patient compliance. Summary of the Invention

[0005] To address the problems of inconvenient administration, poor taste, low absorption efficiency, slow onset of action, and unreasonable formulation in existing traditional Chinese medicine preparations for treating cervical and lumbar spine diseases, this invention provides a traditional Chinese medicine preparation for treating cervical and lumbar spine diseases. This preparation has a scientific and reasonable formula, is based on the principle of food and medicine being of the same origin, and has a definite curative effect. It adopts a solid beverage dosage form, which is convenient to take, has a good taste, and can quickly relieve symptoms such as pain, stiffness, and numbness caused by cervical and lumbar spine diseases. It is safe and non-toxic for long-term use, and the preparation process is simple and low in cost, making it suitable for large-scale production.

[0006] A traditional Chinese medicine preparation for treating cervical and lumbar spondylosis, comprising the following raw materials in parts by weight: Polygonatum 15-30 parts, Zaocys dhumnades 10-20 parts, Chaenomeles speciosa 12-25 parts, Ginseng 5-15 parts, Peach kernel 8-18 parts, Kudzu root 10-25 parts, Fructooligosaccharides 5-12 parts, Malt flavoring 0.1-0.5 parts.

[0007] Furthermore, it includes the following raw materials in parts by weight: Polygonatum 20-25 parts, Zaocys dhumnades 12-18 parts, Chaenomeles speciosa 15-20 parts, Panax ginseng 8-12 parts, Prunus persica 10-15 parts, Pueraria lobata 15-20 parts, Fructooligosaccharides 8-10 parts, Malt flavoring 0.2-0.4 parts.

[0008] Furthermore, it includes the following raw materials in parts by weight: 22 parts Polygonatum sibiricum, 15 parts Zaocys dhumnades, 18 parts Chaenomeles speciosa, 10 parts Ginseng, 12 parts Prunus persica, 18 parts Pueraria lobata, 9 parts Fructooligosaccharides, and 0.3 parts Malt Flavoring.

[0009] Furthermore, the preparation method includes the following steps: S1: Raw material pretreatment: Select Polygonatum sibiricum, Zaocys dhumnades, Chaenomeles speciosa, Panax ginseng, Prunus persica, and Pueraria lobata that meet the pharmacopoeia standards, remove impurities, mud, and insect-infested parts, wash and air dry; Zaocys dhumnades are freeze-dried at low temperature, with a freezing temperature of -20℃ to -15℃ and a drying time of 12-18 hours, and then pulverized to 80-100 mesh to obtain Zaocys dhumnades powder; Polygonatum sibiricum, Chaenomeles speciosa, Panax ginseng, Prunus persica, and Pueraria lobata are sliced ​​or pulverized to 60-80 mesh respectively; S2: Extraction of effective components from traditional Chinese medicine: Mix the pretreated Polygonatum, papaya, ginseng, peach kernel and kudzu root, add 8-12 times the weight of deionized water, and soak for 30-60 minutes; heat to boiling, maintain a simmer and decoct 2-3 times, each time for 60-90 minutes, combine all the extracts to obtain a mixed extract of traditional Chinese medicine. S3: Purification and Concentration of Extract: Let the mixed extract of Chinese herbal medicine stand for 12-24 hours to remove the lower precipitate; filter it through a plate and frame filter with a filtration precision of 100-120 mesh to obtain a clear extract; send the clear extract into a rotary evaporator and concentrate it under a vacuum of 0.06-0.08 MPa and a temperature of 60-70℃ to obtain a concentrated paste with a relative density of 1.10-1.15 (25℃); S4: Mixing and Drying: Add the prepared *Zaocys dhumnades* powder from step 1 to the concentrated paste prepared in step 3, and stir evenly to obtain a mixed paste; add fructooligosaccharides and malt flavoring to the mixed paste, and continue stirring for 20-30 minutes until evenly mixed; send the mixed paste into a spray dryer, set the inlet air temperature to 160-180℃, the outlet air temperature to 70-80℃, and the feed rate to 20-30mL / min, and perform spray drying to obtain a dried solid powder; S5: Crushing, sieving and packaging: The solid powder obtained by spray drying is crushed to 100-120 mesh and sieved through a 100-120 mesh sieve; it is then packaged into individual bags of 10-20g each using aseptic packaging equipment, sealed, and after passing inspection, it becomes the finished product.

[0010] Furthermore, in step 1, the freeze-drying temperature of the black-striped snake is -18℃, the drying time is 15 hours, and it is pulverized to 90 mesh; the Solomon's seal, papaya, ginseng, peach kernel, and kudzu root are pulverized to 70 mesh.

[0011] Furthermore, in step 2, the amount of water added is 10 times the weight, the soaking time is 45 minutes, and it is decocted 3 times, each time for 75 minutes.

[0012] Further, in step 3, the standing time is 18 hours, the filtration accuracy is 110 mesh, the vacuum degree is 0.07 MPa, the temperature is 65℃, and the concentrate is concentrated to a concentrated paste with a relative density of 1.12 (25℃).

[0013] Furthermore, in step 4, the stirring time is 25 minutes, the inlet air temperature of the spray dryer is 170℃, the outlet air temperature is 75℃, and the feed rate is 25mL / min.

[0014] Furthermore, the preparation is used to relieve symptoms of pain, stiffness, numbness, and limited mobility caused by cervical and lumbar degenerative diseases and chronic strain, and is a food and medicine homology preparation.

[0015] Explanation of the efficacy of raw material components: The formula of this invention follows the principles of traditional Chinese medicine, which emphasizes both addressing the root cause and symptoms and treating according to syndrome differentiation. Combined with modern pharmacological research, it selects and rationally combines medicinal and edible herbs. The components work synergistically to achieve the effects of tonifying the liver and kidneys, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, dispelling wind and dampness, relieving pain and reducing swelling. Specific effects are as follows: Polygonatum rhizome: sweet in taste and neutral in nature, it enters the spleen, lung, and kidney meridians. It has the effects of tonifying qi and nourishing yin, strengthening the spleen and moistening the lungs, and benefiting the kidneys and replenishing essence. Modern pharmacological research shows that the main active ingredients of Polygonatum rhizome include polysaccharides, polyphenols, alkaloids, and saponins, which have antioxidant, anti-inflammatory, and osteocyte differentiation-promoting biological functions. It can improve microcirculation in cervical and lumbar spine lesions, reduce inflammatory responses, repair damaged tissue cells, enhance the body's immunity, delay the progression of cervical and lumbar spine degenerative diseases, and provide lasting conditioning support to the body. It fundamentally improves the physical constitution of cervical and lumbar spine diseases, especially suitable for patients with liver and kidney deficiency-type cervical and lumbar spine diseases caused by long-term strain. It is one of the "principal herbs" in the formula, playing a core role in tonifying the liver and kidneys and strengthening the body's resistance.

[0016] Black-striped snake (Zaocys dhumnades): Sweet in taste and neutral in nature, it enters the liver meridian. It has the effects of dispelling wind and unblocking the meridians, relieving spasms and pain, and is a commonly used medicinal material for treating rheumatic pain, limb numbness, and muscle spasms. Modern pharmacological research has confirmed that the decoction and alcohol extract of black-striped snake have significant anti-inflammatory, sedative, and analgesic effects. Its active ingredients can penetrate the skin and muscle tissue, directly reaching the affected area, relieving symptoms such as muscle spasms, pain, and numbness caused by cervical and lumbar spine diseases. Simultaneously, it can unblock the meridians, improve local blood circulation, and promote the dissipation of blood stasis. It has a good relieving effect on radiating pain caused by nerve root compression. It is a "ministerial herb" in the formula, mainly responsible for dispelling wind and unblocking the meridians, relieving pain and spasms, and quickly relieving the patient's clinical symptoms.

[0017] Papaya: Sour in taste and warm in nature, it enters the liver and spleen meridians. It has the effects of relaxing muscles and tendons, harmonizing the stomach and resolving dampness. It is good at treating symptoms such as dampness-induced arthralgia, lower back and knee pain, and limb contractures. The papain in papaya can break down proteins and promote the body's absorption of nutrients. At the same time, its active ingredients can relieve muscle tension, alleviate stiffness in the cervical and lumbar spine, and improve symptoms of limited joint movement. When combined with black-striped snake, it enhances the effects of relaxing muscles and tendons, relieving pain, and regulating the spleen and stomach, avoiding the stimulation of the gastrointestinal tract by other medicinal materials. It is one of the "assistant herbs" in the formula, assisting the principal herb in its function, and taking into account both the effects of regulating the spleen and stomach and relaxing muscles and relieving pain. It is especially suitable for patients with cervical and lumbar spine diseases caused by dampness obstruction, relieving symptoms such as joint pain and limited movement caused by dampness invasion.

[0018] Ginseng (artificially cultivated for less than five years): sweet and slightly bitter in taste, slightly warm in nature, and enters the spleen, lung, and heart meridians. It has the effects of greatly replenishing vital energy, restoring pulse and consolidating the body, invigorating qi and strengthening the spleen, and promoting body fluid and calming the mind. Artificially cultivated ginseng for less than five years can be used as a new resource food, safe and non-toxic, suitable for long-term use. Its effective components can replenish the body's vital energy, improve the state of insufficient qi and blood, promote blood circulation, enhance the body's metabolic capacity, and repair damaged cervical and lumbar vertebrae. At the same time, it can relieve complications such as fatigue, dizziness, and insomnia caused by long-term illness, providing energy support for the body's recovery. It assists Polygonatum in playing the role of tonifying the liver and kidneys and strengthening the body's resistance. It is an "adjuvant" in the formula, taking into account both the effects of invigorating qi and regulating the body, avoiding the depletion of vital energy caused by promoting blood circulation, removing blood stasis, dispelling wind and unblocking the meridians, and achieving a balance between strengthening the body's resistance and eliminating pathogens.

[0019] Peach kernel: Bitter and sweet in taste, neutral in nature, and enters the heart, liver, and large intestine meridians. It has the effects of promoting blood circulation, removing blood stasis, and moistening the intestines to relieve constipation. Modern pharmacological research shows that peach kernel contains amygdalin, amygdalin, and other components, which can dilate blood vessels, reduce blood viscosity, and inhibit platelet aggregation, thereby promoting blood circulation and removing blood stasis. It can effectively improve the blood stasis in cervical and lumbar spine lesions, reduce the compression of nerve roots by blood stasis, relieve pain symptoms, and promote the dissipation of inflammatory factors, reduce local edema. It works synergistically with black-striped snake and papaya to enhance the effect of clearing the meridians and relieving pain. In addition, peach kernel also has the effect of moistening the intestines to relieve constipation, which can prevent constipation caused by long-term bed rest or medication. It can maintain the body's normal metabolic function and is one of the "adjuvant drugs" in the formula. It is mainly responsible for promoting blood circulation, removing blood stasis, and relieving pain, while also regulating intestinal function and reducing the side effects of the preparation.

[0020] Kudzu root: sweet and pungent in taste, cool in nature, and enters the spleen, stomach, and lung meridians. It has the effects of relieving muscle tension and fever, promoting body fluid production and quenching thirst, and unblocking meridians and collaterals. It is an important medicine for treating stiff neck and back pain, especially suitable for the conditioning and treatment of cervical spondylosis. Modern pharmacological research shows that the puerarin component contained in kudzu root can antagonize the damaging effect of glutamate on nerve cells, dilate microarteries, and improve microcirculation disorders, and has a certain curative effect on cervical spondylosis of nerve root type and spinal cord type. Puerarin can also increase cerebral microcirculation blood flow and improve symptoms such as dizziness, tinnitus, and limb numbness caused by insufficient blood supply to the brain. At the same time, kudzu root extract can inhibit the activity of inflammatory mediators, delay the degeneration of cervical intervertebral discs, relax neck smooth muscles, and relieve carotid artery spasm, thereby effectively relieving symptoms such as cervical stiffness, pain, and upper limb numbness. It works synergistically with peach kernel to enhance the effects of promoting blood circulation, removing blood stasis, unblocking meridians, and relieving pain. It is an "adjuvant" in the formula, focusing on conditioning the lesion site of cervical spondylosis, improving the therapeutic effect of the preparation on cervical spondylosis, and at the same time helping to relieve limb numbness caused by lumbar lesions.

[0021] Fructooligosaccharides (FOS): As a sweetener and prebiotic, FOS is sweet and odorless, improving the taste of the preparation, masking the bitterness of traditional Chinese medicine, and enhancing patient compliance. Simultaneously, FOS promotes the growth and reproduction of beneficial bacteria in the gut, enhances the intestinal mucosal barrier function, promotes the absorption of effective components of traditional Chinese medicine, improves the bioavailability of the preparation, improves intestinal function, alleviates gastrointestinal discomfort that may be caused by taking traditional Chinese medicine, and also lowers cholesterol and enhances the body's immunity. Working synergistically with the traditional Chinese medicine components in the formula, it further enhances the conditioning effect of the preparation. As one of the "guide drugs" in the formula, it is responsible for flavoring, promoting absorption, and reducing gastrointestinal irritation, balancing the dual needs of taste and drug absorption. It is also sugar-free, making it suitable for all types of people, especially patients with cervical and lumbar spine diseases accompanied by high blood sugar.

[0022] Malt flavoring: As a flavor modifier, it can impart a light malt aroma to the preparation, further improve the taste, mask the off-flavor of traditional Chinese medicine, enhance the patient's experience, and ensure that the preparation has a mellow and easily accepted taste. It is especially suitable for young patients with high requirements for taste. It is one of the "adjuvants" in the formula, assisting fructooligosaccharides in optimizing the taste of the preparation, improving patient compliance, and is used in very small amounts. It is safe and non-toxic, meets the relevant standards for food additives, does not affect the efficacy of the preparation, and works synergistically with other components to achieve a balance between taste and efficacy.

[0023] In this invention's formula, the principal herb (Polygonatum sibiricum) is responsible for tonifying the liver and kidneys, strengthening the body's constitution, and addressing the root cause of cervical and lumbar degenerative diseases. The assistant herbs (Smilax china, Chaenomeles speciosa) are responsible for dispelling wind, clearing the meridians, relaxing muscles and relieving pain, quickly alleviating patients' clinical symptoms such as pain, stiffness, and numbness. The adjuvant herbs (ginseng, peach kernel, kudzu root) assist the principal and assistant herbs in their effects, simultaneously tonifying qi, promoting blood circulation, removing blood stasis, clearing the meridians and relieving pain, while also regulating intestinal function and enhancing efficacy. The guiding herbs (fructooligosaccharides, malt flavoring) are responsible for flavoring, promoting absorption, reducing side effects, and improving the user experience and bioavailability of the preparation. The scientific combination and synergistic effects of each component focus on both rapid symptom relief and root cause treatment, achieving a comprehensive cure. Furthermore, all the medicinal materials are of the same origin as food, and artificially cultivated ginseng less than five years old meets the standards for new resource foods, ensuring safety and non-toxicity, making it suitable for long-term use without significant side effects. This solves the problem of existing Chinese medicine preparations having significant side effects and being unsuitable for long-term use.

[0024] The beneficial effects of this invention are as follows: 1. Scientifically formulated and effective: This invention selects medicinal and edible herbs such as Polygonatum sibiricum, Zaocys dhumnades, and Chaenomeles speciosa, and follows the principle of "treating both the symptoms and the root cause" in traditional Chinese medicine. The ingredients are rationally combined, and the synergistic effect of each component can not only quickly relieve the symptoms of pain, stiffness, and numbness caused by cervical and lumbar spine diseases, but also nourish the liver and kidneys, promote blood circulation and remove blood stasis, regulate the body's constitution, and delay the degenerative changes of the cervical and lumbar spine, thus achieving both symptomatic and root cause treatment.

[0025] 2. Novel dosage form and convenient administration: This invention transforms traditional Chinese medicine preparations into a solid beverage dosage form, overcoming the drawbacks of traditional decoctions, pills, and capsules. It is convenient to carry and easy to take, requiring only warm water to dissolve, making it suitable for various groups such as office workers, the elderly, and outdoor enthusiasts. At the same time, through the rational combination of fructooligosaccharides and malt flavoring, the bitter taste of traditional Chinese medicine is improved, enhancing patient compliance, making it especially suitable for long-term use. This solves the problems of poor taste and low patient compliance in traditional Chinese medicine preparations, expanding the applicable population of the preparation, and is especially suitable for young and elderly patients with high requirements for taste.

[0026] 3. Safe and non-toxic with minimal side effects: All the Chinese herbal raw materials used in this invention are food and medicine homologous. The ginseng is selected from varieties cultivated for less than five years, meeting the national standards for new resource foods. It is safe and non-toxic, suitable for long-term use. The preparation process uses water decoction extraction, without adding any preservatives, pigments, or other harmful additives, resulting in no obvious side effects. This avoids the gastrointestinal discomfort and liver and kidney damage caused by long-term use of Western medicine and traditional Chinese medicine preparations. It has high safety and is suitable for long-term conditioning use by various groups of people, especially patients with cervical and lumbar spine diseases accompanied by gastrointestinal diseases and weak liver and kidney function. It solves the problem of insufficient safety and unsuitability for long-term use of existing preparations, improving the clinical applicability and safety of the preparation.

[0027] 4. Simple preparation process and low cost: The preparation method of this invention adopts conventional processes such as water decoction and spray drying, which are simple to operate and have a clear process. No complicated equipment and technology are required, which is conducive to large-scale production. At the same time, the raw materials are widely available and low in cost. The extraction rate of effective components is high and the utilization rate of raw materials is high during the preparation process, which reduces resource waste and lowers production costs. This is conducive to the promotion and application of the product and solves the problems of complex preparation processes, high costs and difficulty in large-scale production of existing traditional Chinese medicine preparations. It has significant economic and social benefits.

[0028] 5. Stable active ingredients and long shelf life: This invention uses low-temperature freeze-drying and spray drying processes to maximize the preservation of the active ingredients of traditional Chinese medicine, avoiding the loss and damage of active ingredients. At the same time, the sealed and individually packaged packaging can prevent the powder from absorbing moisture and oxidizing, extending the shelf life of the preparation and ensuring the stability of the efficacy of the preparation within the shelf life. This solves the problems of unstable active ingredients and short shelf life of existing traditional Chinese medicine preparations, and enhances the market competitiveness and practicality of the product. Attached Figure Description

[0029] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0030] Figure 1 This is a flowchart illustrating the preparation process of the present invention. Detailed Implementation

[0031] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations. Example

[0032] A traditional Chinese medicine solid beverage preparation for treating cervical and lumbar spondylosis, comprising the following raw materials in parts by weight: 15 parts Polygonatum sibiricum, 10 parts Zaocys dhumnades, 12 parts Chaenomeles speciosa, 5 parts Ginseng (artificially cultivated for less than five years), 8 parts Prunus persica, 10 parts Pueraria lobata, 5 parts fructooligosaccharides, and 0.1 parts malt flavoring.

[0033] Preparation method: Step 1: Raw material pretreatment: Select Polygonatum, Zaocys dhumnades, Chaenomeles speciosa, Ginseng (artificially cultivated for less than five years), Prunus persica, and Pueraria lobata that meet the pharmacopoeia standards. Remove impurities, mud, and insect-infested parts, wash and dry them. Zaocys dhumnades are freeze-dried at low temperature at -20℃ for 12 hours. After drying, they are pulverized to 80 mesh to obtain Zaocys dhumnades powder. Polygonatum, Chaenomeles speciosa, Ginseng, Prunus persica, and Pueraria lobata are sliced ​​and pulverized to 60 mesh.

[0034] Step 2: Extraction of effective components from traditional Chinese medicine: Mix the pretreated Polygonatum, papaya, ginseng, peach kernel and kudzu root, add 8 times the weight of deionized water and soak for 30 minutes; heat to boiling, keep at a simmer and decoct twice, each time for 60 minutes, combine the two extracts to obtain a mixed extract of traditional Chinese medicine.

[0035] Step 3: Purification and concentration of extract: Let the mixed extract of Chinese medicine stand for 12 hours to remove the lower precipitate; filter it through a plate and frame filter with a filtration precision of 100 mesh to obtain a clear extract; send the clear extract into a rotary evaporator and concentrate it under a vacuum of 0.06 MPa and a temperature of 60°C to a concentrated paste with a relative density of 1.10 (25°C).

[0036] Step 4: Mixing and Drying: Add the black snake powder to the concentrated paste and stir evenly; add fructooligosaccharides and malt flavoring, and continue stirring for 20 minutes until evenly mixed; send the mixed paste into a spray dryer, set the inlet air temperature to 160℃, the outlet air temperature to 70℃, and the feed rate to 20mL / min, and spray dry to obtain a dry solid powder.

[0037] Step 5: Crushing, sieving and packaging: Crush the solid powder to 100 mesh and sieve it through a 100-mesh sieve; use aseptic packaging equipment to package it into individual 5g bags, seal them, affix labels, and after passing inspection, it becomes the finished product. Example

[0038] A traditional Chinese medicine solid beverage preparation for treating cervical and lumbar spondylosis, comprising the following raw materials in parts by weight: 25 parts Polygonatum sibiricum, 18 parts Zaocys dhumnades, 20 parts Chaenomeles speciosa, 12 parts Ginseng (artificially cultivated for less than five years), 15 parts Prunus persica, 20 parts Pueraria lobata, 10 parts fructooligosaccharides, and 0.4 parts malt flavoring.

[0039] Preparation method: Step 1: Raw material pretreatment: Select Polygonatum sibiricum, Zaocys dhumnades, Chaenomeles speciosa, Ginseng (artificially cultivated for less than five years), Prunus persica, and Pueraria lobata that meet the pharmacopoeia standards. Remove impurities, mud, and insect-infested parts, wash and dry them. Zaocys dhumnades are freeze-dried at low temperature at -18℃ for 15 hours. After drying, they are pulverized to 90 mesh to obtain Zaocys dhumnades powder. Polygonatum sibiricum, Chaenomeles speciosa, Ginseng, Prunus persica, and Pueraria lobata are sliced ​​and pulverized to 70 mesh.

[0040] Step 2: Extraction of effective components from traditional Chinese medicine: Mix the pretreated Polygonatum, papaya, ginseng, peach kernel and kudzu root, add 10 times the weight of deionized water and soak for 45 minutes; heat to boiling, maintain a simmer and decoct 3 times, each time for 75 minutes, combine the three extracts to obtain a mixed extract of traditional Chinese medicine.

[0041] Step 3: Purification and concentration of extract: Let the mixed extract of Chinese medicine stand for 18 hours to remove the lower precipitate; filter it through a plate and frame filter with a filtration precision of 110 mesh to obtain a clear extract; send the clear extract into a rotary evaporator and concentrate it under a vacuum of 0.07 MPa and a temperature of 65°C to a concentrated paste with a relative density of 1.12 (25°C).

[0042] Step 4: Mixing and drying: Add the black snake powder to the concentrated paste and stir evenly; add fructooligosaccharides and malt flavoring, and continue stirring for 25 minutes until evenly mixed; send the mixed paste into a spray dryer, set the inlet air temperature to 170℃, the outlet air temperature to 75℃, and the feed rate to 25mL / min, and spray dry to obtain a dry solid powder.

[0043] Step 5: Crushing, sieving and packaging: Crush the solid powder to 110 mesh and sieve it through a 110 mesh sieve; use aseptic packaging equipment to package it into individual 8g bags, seal them, affix labels, and after passing inspection, it becomes the finished product. Example

[0044] A traditional Chinese medicine solid beverage preparation for treating cervical and lumbar spondylosis, comprising the following raw materials in parts by weight: 22 parts Polygonatum sibiricum, 15 parts Zaocys dhumnades, 18 parts Chaenomeles speciosa, 10 parts Ginseng (artificially cultivated for less than five years), 12 parts Prunus persica, 18 parts Pueraria lobata, 9 parts fructooligosaccharides, and 0.3 parts malt flavoring.

[0045] Preparation method: Step 1: Raw material pretreatment: Select Polygonatum, Zaocys dhumnades, Chaenomeles speciosa, Ginseng (artificially cultivated for less than five years), Prunus persica, and Pueraria lobata that meet the pharmacopoeia standards. Remove impurities, mud, and insect-infested parts, wash and dry them. Zaocys dhumnades are freeze-dried at low temperature at -15℃ for 18 hours. After drying, they are pulverized to 100 mesh to obtain Zaocys dhumnades powder. Polygonatum, Chaenomeles speciosa, Ginseng, Prunus persica, and Pueraria lobata are sliced ​​and pulverized to 80 mesh.

[0046] Step 2: Extraction of effective components from traditional Chinese medicine: Mix the pretreated Polygonatum, papaya, ginseng, peach kernel and kudzu root, add 12 times the weight of deionized water and soak for 60 minutes; heat to boiling, keep at a simmer and decoct 3 times, each time for 90 minutes, combine the three extracts to obtain a mixed extract of traditional Chinese medicine.

[0047] Step 3: Purification and concentration of extract: Let the mixed extract of Chinese medicine stand for 24 hours to remove the lower precipitate; filter it through a plate and frame filter with a filtration precision of 120 mesh to obtain a clear extract; send the clear extract into a rotary evaporator and concentrate it under a vacuum of 0.08 MPa and a temperature of 70°C to a concentrated paste with a relative density of 1.15 (25°C).

[0048] Step 4: Mixing and drying: Add the black snake powder to the concentrated paste and stir evenly; add fructooligosaccharides and malt flavoring, and continue stirring for 30 minutes until evenly mixed; send the mixed paste into a spray dryer, set the inlet air temperature to 180℃, the outlet air temperature to 80℃, and the feed rate to 30mL / min, and spray dry to obtain a dry solid powder.

[0049] Step 5: Crushing, sieving and packaging: Crush the solid powder to 120 mesh and sieve it through a 120 mesh sieve; use aseptic packaging equipment to package it into individual 10g bags, seal them, affix labels, and after passing inspection, it becomes the finished product. Example

[0050] A traditional Chinese medicine solid beverage preparation for treating cervical and lumbar spondylosis, comprising the following raw materials in parts by weight: 30 parts Polygonatum sibiricum, 20 parts Zaocys dhumnades, 25 parts Chaenomeles speciosa, 15 parts Ginseng (artificially cultivated for less than five years), 18 parts Prunus persica, 25 parts Pueraria lobata, 12 parts fructooligosaccharides, and 0.5 parts malt flavoring.

[0051] The preparation method is basically the same as in Example 3, with only the amount of raw materials and some process parameters adjusted: the amount of water added during extraction is 12 times the weight, the soaking time is 60 minutes, and the decoction is performed 3 times, each time for 90 minutes; the concentration relative density is 1.15 (25℃); the spray drying inlet air temperature is 180℃ and the outlet air temperature is 80℃; and it is packaged in 10g bags.

[0052] In summary, the formulation of this invention is a food-medicine homology formula, which is safe and non-toxic. It adopts a solid beverage dosage form, which is convenient to take, has a good taste, stable active ingredients, and high bioavailability. It can quickly relieve symptoms such as pain, stiffness, and numbness caused by cervical and lumbar degenerative diseases and chronic strain. Long-term use can regulate the body's constitution and delay the progression of diseases. It has significant clinical application value and market prospects.

[0053] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine preparation for treating cervical and lumbar spondylosis, characterized in that, Including the following parts by weight of raw materials: Polygonatum 15-30 parts, Zaocys dhumnades 10-20 parts, Chaenomeles speciosa 12-25 parts, Ginseng 5-15 parts, Peach kernel 8-18 parts, Kudzu root 10-25 parts, Fructooligosaccharides 5-12 parts, Malt flavoring 0.1-0.5 parts.

2. The traditional Chinese medicine preparation for treating cervical and lumbar spondylosis according to claim 1, characterized in that, Including the following parts by weight of raw materials: Polygonatum 20-25 parts, Zaocys dhumnades 12-18 parts, Chaenomeles speciosa 15-20 parts, Panax ginseng 8-12 parts, Prunus persica 10-15 parts, Pueraria lobata 15-20 parts, Fructooligosaccharides 8-10 parts, Malt flavoring 0.2-0.4 parts.

3. A traditional Chinese medicine preparation for treating cervical and lumbar spondylosis according to claim 1, characterized in that, Including the following parts by weight of raw materials: 22 parts Polygonatum sibiricum, 15 parts Zaocys dhumnades, 18 parts Chaenomeles speciosa, 10 parts Ginseng, 12 parts Prunus persica, 18 parts Pueraria lobata, 9 parts Fructooligosaccharides, and 0.3 parts Malt Flavoring.

4. A traditional Chinese medicine preparation for treating cervical and lumbar spondylosis according to claim 1, characterized in that, The preparation method includes the following steps: S1: Raw material pretreatment: Select Polygonatum sibiricum, Zaocys dhumnades, Chaenomeles speciosa, Panax ginseng, Prunus persica, and Pueraria lobata that meet the pharmacopoeia standards, remove impurities, mud, and insect-infested parts, wash and air dry; Zaocys dhumnades are freeze-dried at low temperature, with a freezing temperature of -20℃ to -15℃ and a drying time of 12-18 hours, and then pulverized to 80-100 mesh to obtain Zaocys dhumnades powder; Polygonatum sibiricum, Chaenomeles speciosa, Panax ginseng, Prunus persica, and Pueraria lobata are sliced ​​or pulverized to 60-80 mesh respectively; S2: Extraction of effective components from traditional Chinese medicine: Mix the pretreated Polygonatum, papaya, ginseng, peach kernel and kudzu root, add 8-12 times the weight of deionized water, and soak for 30-60 minutes; heat to boiling, maintain a simmer and decoct 2-3 times, each time for 60-90 minutes, combine all the extracts to obtain a mixed extract of traditional Chinese medicine. S3: Purification and Concentration of Extract: Let the mixed extract of Chinese herbal medicine stand for 12-24 hours to remove the lower precipitate; filter it through a plate and frame filter with a filtration precision of 100-120 mesh to obtain a clear extract; send the clear extract into a rotary evaporator and concentrate it under a vacuum of 0.06-0.08 MPa and a temperature of 60-70℃ to obtain a concentrated paste with a relative density of 1.10-1.15 (25℃); S4: Mixing and Drying: Add the prepared *Zaocys dhumnades* powder from step 1 to the concentrated paste prepared in step 3, and stir evenly to obtain a mixed paste; add fructooligosaccharides and malt flavoring to the mixed paste, and continue stirring for 20-30 minutes until evenly mixed; send the mixed paste into a spray dryer, set the inlet air temperature to 160-180℃, the outlet air temperature to 70-80℃, and the feed rate to 20-30mL / min, and perform spray drying to obtain a dried solid powder; S5: Crushing, sieving and packaging: The solid powder obtained by spray drying is crushed to 100-120 mesh and sieved through a 100-120 mesh sieve; it is then packaged into individual bags of 10-20g each using aseptic packaging equipment, sealed, and after passing inspection, it becomes the finished product.

5. The preparation method according to claim 4, characterized in that, In step 1, the freeze-drying temperature of the black-striped snake is -18℃, the drying time is 15 hours, and it is pulverized to 90 mesh; the Solomon's seal, papaya, ginseng, peach kernel, and kudzu root are pulverized to 70 mesh.

6. The preparation method according to claim 4, characterized in that, In step 2, add water at a volume of 10 times the weight, soak for 45 minutes, and decoct 3 times, each time for 75 minutes.

7. The preparation method according to claim 4, characterized in that, In step 3, the standing time is 18 hours, the filtration accuracy is 110 mesh, the vacuum degree is 0.07 MPa, the temperature is 65℃, and the concentration is concentrated to a concentrated paste with a relative density of 1.12 (25℃).

8. The preparation method according to claim 4, characterized in that, In step 4, the stirring time is 25 minutes, the inlet air temperature of the spray dryer is 170℃, the outlet air temperature is 75℃, and the feed rate is 25mL / min.

9. The traditional Chinese medicine preparation for treating cervical and lumbar spondylosis according to any one of claims 1-3, characterized in that, The preparation is used to relieve symptoms of pain, stiffness, numbness, and limited mobility caused by degenerative changes in the cervical and lumbar spine and chronic strain, and it is a food-grade preparation.

Images