Multi-cavity micro-fluidic chip level instant-preparation infusion device
The multi-chamber microfluidic chip-level ready-to-use infusion device solves the problems of cumbersome operation, low precision, and contamination risk of existing ready-to-use infusion devices, and realizes precise drug mixing and infusion, meeting the needs of clinical infusion for closed, precise, and portable infusion.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FUJIAN PROVINCIAL HOSPITAL
- Filing Date
- 2026-03-26
- Publication Date
- 2026-05-15
AI Technical Summary
Existing ready-to-use infusion devices suffer from problems such as cumbersome operation, low precision, susceptibility to contamination, large size, and inability to achieve precise mixing and infusion of micro-drugs. Furthermore, existing microfluidic chip technology fails to meet the needs of clinical infusion for closed, precise, and portable solutions.
Design a multi-chamber microfluidic chip-level ready-to-use infusion device, including a microfluidic chip body, a drive component, a temperature control component, and a connection component. It adopts micron-level flow channels and high-precision micro control valves and micro pumps to achieve precise mixing and infusion of drugs in a closed environment. It integrates temperature control function, miniaturizes the device, and is compatible with existing infusion tubing.
It achieves absolute precision in drug formulation, avoids cross-contamination, ensures temperature stability, and is small and portable, improving the convenience of emergency care and bedside nursing.
Smart Images
Figure CN122031818A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical infusion technology, specifically to a multi-chamber microfluidic chip-level ready-to-use infusion device. Background Technology
[0002] In clinical medicine, many drugs (such as antibiotics, chemotherapy drugs, and biological agents) are unstable and cannot be prepared and stored in advance. They need to be mixed with the infusion solvent immediately before use, which is called "ready-to-use infusion". Currently, there are two main methods of ready-to-use infusion commonly used in clinical practice: one is for medical staff to manually dissolve the drug powder and inject it into the infusion bag. This method is cumbersome, inefficient, and has low accuracy in manual mixing, which is prone to dosage errors. At the same time, the drug is easily exposed to air during the operation, increasing the risk of contamination. The other method uses a double-chamber or multi-chamber infusion bag, which separates the solvent and drug through weakly welded separators or easily broken sealing membranes. When in use, the chambers are squeezed to break the sealing structure and achieve mixing. However, this type of device has problems such as the sealing membrane being easily damaged, leading to premature mixing of drugs, fixed ratios that cannot be flexibly adjusted, large size that is inconvenient to carry, and it cannot achieve precise mixing and infusion of micro-volume drugs.
[0003] Microfluidic chip technology integrates biological, chemical, and medical processes onto a micrometer-scale chip, offering advantages such as small size, high precision, low consumption, and low risk of contamination. However, current technology lacks a device that deeply integrates microfluidic chip technology with the needs of ready-to-use infusions, possessing integrated functions of independent fluid storage, precise drive, intelligent temperature control, and aseptic infusion. Existing microfluidic structures have not been optimized for the closed, precise, and portable requirements of clinical infusions, making it difficult to meet the urgent needs of modern medicine for precise, sterile, and immediate delivery of multi-component drugs. Summary of the Invention
[0004] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows: The multi-chamber microfluidic chip-level ready-to-use infusion device according to an embodiment of the present invention includes a microfluidic chip body, a driving component, a temperature control component, and a connecting component; The microfluidic chip body includes a cover plate and a chip substrate. The cover plate and the chip substrate are sealed together to form a closed chamber structure. At least two independent liquid storage chambers, a micro-mixing channel, and a liquid outlet chamber are formed on the chip substrate. Each liquid storage chamber is connected to the input end of the micro-mixing channel through an independent micro-channel. The output end of the micro-mixing channel is connected to the liquid outlet chamber. Each micro-channel is provided with a micro control valve for controlling the channel opening and closing and the flow rate. The top of the liquid storage chamber is provided with a liquid inlet that penetrates the chip substrate. The liquid inlet is provided with a removable sealing plug. The driving component includes a micropump and a control module. The micropump is connected to each of the liquid storage chambers and is used to provide precise driving force to the liquid in the liquid storage chambers. The control module is electrically connected to the micropump and the micro control valve and is used to control the output flow of the micropump and the on / off state of the micro control valve. The temperature control component includes a heating element and a temperature sensor. The heating element is attached to the top of the chip substrate, and the temperature sensor is embedded in the chip substrate and located near the liquid storage chamber. The temperature sensor is electrically connected to the control module, and the control module adjusts the heating power of the heating element according to the detection signal of the temperature sensor. The connecting assembly includes a liquid outlet interface, which is disposed on the cover plate and communicates with the liquid outlet chamber. The liquid outlet interface is used for sealed connection with an external infusion pipeline.
[0005] The number of liquid storage chambers is 2-4, and the volume of each liquid storage chamber is 10-100μL. The inner wall of each liquid storage chamber is covered with a hydrophilic layer, which is a silica layer or a polyethylene glycol modified layer.
[0006] The micro-mixing channel adopts a spiral structure with an inner diameter of 0.5-2 mm, a width of 10-50 μm, and a depth of 5-20 μm. The connection between the micro-channel and the micro-mixing channel adopts an arc-shaped transition structure.
[0007] The micro control valve is an electromagnetic control valve or a piezoelectric control valve, and the control accuracy of the micro control valve is not less than 0.1 μL / min, and the response time is not more than 10 ms.
[0008] The micropump is a micro peristaltic pump or a piezoelectric micropump, and the output flow rate of the micropump is adjustable from 0.1 to 10 μL / min, with a flow rate accuracy of not less than ±0.05 μL / min.
[0009] The temperature control component has a temperature control range of 20-37℃ and a temperature control accuracy of not less than ±0.5℃. The heating element is a flexible heating element that fits and covers the entire top of the chip substrate.
[0010] Both the cover plate and the chip substrate are made of biocompatible materials, such as polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), or glass.
[0011] The connecting assembly also includes a sealing connector, the liquid outlet is threadedly connected to the sealing connector, the other end of the sealing connector is provided with a Luer interface adapted to an external infusion pipeline, and the sealing connector is provided with a sealing ring.
[0012] The control module is equipped with an independent display screen and operation buttons. The display screen is used to display the liquid level, infusion flow rate, and chip temperature of each of the liquid storage chambers. The display screen is powered by an internal battery, and a charging interface is provided on the side of the display screen casing. The operation buttons are used to set infusion parameters and start / stop infusion.
[0013] The main body of the microfluidic chip has a size of 20-50mm×20-50mm×1-5mm, and the weight of the entire device does not exceed 50g.
[0014] The advantages of this invention compared to the prior art are: 1. By combining micron-level flow channels with high-precision micro-control valves and micro-pumps, precise control of nanoliter / microliter-level flow rates can be achieved, ensuring absolute accuracy in the formulation of multi-component drugs and avoiding medical risks caused by dosage errors; 2. The entire drug preparation and infusion process is completed inside a completely sealed chip, and the drugs and solvents are not exposed to the external environment, which fundamentally avoids the risk of cross-contamination and bacterial infection; 3. The integrated temperature control component can precisely maintain the temperature of the drug solution within the optimal range of 20-37℃, effectively ensuring the stability and efficacy of temperature-sensitive drugs; 4. The device has an overall size of only 20-50mm×20-50mm×1-5mm and weighs no more than 50g, achieving chip-level miniaturization and integration; it requires no complicated supporting equipment, is easy to operate, and greatly improves the portability and flexibility of emergency care, bedside care and home care.
[0015] 5. The components are arranged in a compact and reasonable manner, and the outlet interface adopts a standard Luer connector, which can be seamlessly compatible with existing clinical infusion tubing and has broad prospects for promotion and application. Attached Figure Description
[0016] Figure 1 This is a schematic diagram of the overall structure of the multi-chamber microfluidic chip-level ready-to-use infusion device of the present invention; Figure 2 This is a cross-sectional view of the internal structure of the multi-chamber microfluidic chip-level ready-to-use infusion device of the present invention; Figure 3 This is a partial enlarged view of the micro-mixing channel of the multi-chamber microfluidic chip-level instant infusion device of the present invention; Figure 4 This is a schematic diagram of the control module display screen of the multi-chamber microfluidic chip-level ready-to-use infusion device of the present invention.
[0017] Figure label: 1. Microfluidic chip body; 11. Cover plate; 12. Chip substrate; 13. Liquid storage chamber; 14. Micro-mixing channel; 15. Liquid outlet chamber; 16. Microchannel; 17. Micro control valve; 18. Liquid inlet port; 19. Sealing plug; Drive component 2; micro pump 21; control module 22; display screen 221; operation buttons 222; charging interface 223; Temperature control component 3; heating element 31; temperature sensor 32; Connection component 4; liquid outlet 41; sealing connector 42. Detailed Implementation
[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.
[0019] Example: A multi-chamber microfluidic chip-level ready-to-use infusion device according to an embodiment of the present invention, such as... Figure 1 As shown, specifically, it includes a microfluidic chip body 1, a driving component 2, a temperature control component 3, and a connecting component 4.
[0020] like Figure 2 As shown, the microfluidic chip body 1 includes a cover plate 11 and a chip substrate 12, both made of polydimethylsiloxane (PDMS) material, which are sealed together by plasma bonding to form a closed chamber structure. The chip substrate 12 has two independent liquid storage chambers 13, a micro-mixing channel 14, and a liquid outlet chamber 15. Each liquid storage chamber 13 has a volume of 50 μL, and its inner wall is covered with a layer of hydrophilic silica to reduce liquid adhesion and improve drug utilization. Figure 3 As shown, each of the liquid storage chambers 13 is connected to the input end of the micro-mixing channel 14 via an independent microchannel 16. The micro-mixing channel 14 has a spiral structure and an inner diameter of 1 mm. The microchannel 16 connecting the liquid storage chamber 13 and the micro-mixing channel 14 has a width of 30 μm and a depth of 10 μm. The connection with the micro-mixing channel 14 is designed as a smooth arc transition structure to reduce fluid resistance. The output end of the micro-mixing channel 14 is connected to the liquid outlet chamber 15. Each microchannel 16 is equipped with an electromagnetic control valve (micro control valve 17) for precise control of the channel opening and closing and flow rate. Its control accuracy is 0.1 μL / min and the response time is 8 ms. The top of the liquid storage chamber 13 is provided with a liquid inlet 18 that penetrates the chip substrate 12 for injecting drugs or solvents. The liquid inlet 18 is equipped with a removable sealing plug 19 to achieve sealing. The sealing plug 19 is made of medical-grade silicone.
[0021] like Figure 4As shown, the driving component 2 includes a micropump 21 and a control module 22. The micropump 21 is a micro peristaltic pump, which is connected to the two liquid storage chambers 13 one-to-one, providing precise driving force for the liquid in the liquid storage chambers 13. The output flow rate of the micropump 21 is adjustable from 0.1 to 10 μL / min, and the flow rate control accuracy is ±0.05 μL / min. The control module 22 is controlled by a microcontroller and is electrically connected to the micropump 21 and the micro control valves 17. It is responsible for controlling the output flow rate of the micropump 21 and the on / off timing and opening degree of all the micro control valves 17. The control module 22 integrates an independent LCD display screen 221 and a set of membrane operation buttons 222. The display screen 221 can display the remaining liquid volume in each liquid storage chamber, the current infusion flow rate, and the chip substrate temperature in real time. The operation buttons 222 are used by medical staff to set infusion parameters (such as the ratio and infusion rate) and start / stop the infusion program.
[0022] The temperature control component 3 includes a heating element 31 and a temperature sensor 32. The heating element 31 is a flexible thin-film heating element that is attached to and covers the entire top surface of the chip substrate 12 to provide a uniform heat source. The temperature sensor 32 is an NTC thermistor that is embedded inside the chip substrate 12 and is located close to the liquid storage chamber 13 to monitor the temperature of the chip substrate in real time. The temperature control component 3 has a temperature control range of 25-37℃ and a temperature control accuracy of ±0.3℃. The temperature sensor (32) is electrically connected to the control module (22). The control module 22 has a built-in PID algorithm that can accurately adjust the duty cycle of the heating element 31 according to the feedback signal of the temperature sensor 32 to achieve stable constant temperature control and thus keep the chip temperature stable within the set range.
[0023] The connecting component 4 includes an outlet port 41 and a sealing connector 42. The outlet port 41 is located on the cover plate 11 and communicates with the inside of the outlet chamber 15 for sealing connection with external infusion tubing. The sealing connector 42 is threaded to the outlet port 41, and the other end is provided with a Luer interface adapted to standard infusion tubing. It has a sealing ring inside and can achieve sterile and leak-free rapid connection with most intravenous infusion tubing on the market.
[0024] The microfluidic chip body 1 described in this embodiment has a size of 30mm×30mm×2mm and the overall device weighs about 25g. It has a compact structure and is easy to operate by hand.
[0025] The specific steps for using the multi-chamber microfluidic chip-level ready-to-use infusion device are as follows: (1) Device preparation and drug injection: Take out the microfluidic chip body 1 and confirm that the cover plate 11 and the chip substrate 12 are sealed. Open the sealing plug 19 of the liquid inlet port 18 at the top of the liquid storage chamber 13 and inject the corresponding solvent and drug components into each independent liquid storage chamber 13. After the injection is completed, reset the sealing plug 19 to ensure that each liquid storage chamber 13 is in a sealed state. (2) Pipeline connection and air tightness check: Tightly connect the liquid outlet 41 of the connection component 4 to the sealing joint 42, and connect the external infusion pipeline through the Luer interface at the end of the sealing joint 42 to confirm that the sealing ring is reliable, with no leakage or air ingress. (3) Parameter setting and temperature control start-up: Set the infusion parameters through the operation button 222 of the control module 22, including the ratio of each group, the infusion flow rate and the target temperature; start the temperature control component 3, the heating element 31 heats the chip substrate 12, the temperature sensor 32 collects the temperature signal in real time and feeds it back to the control module 22, and the control module 22 automatically adjusts the heating power to stabilize the internal temperature of the chip within the set range. (4) Drug mixing and infusion start-up: After the temperature stabilizes, the drive component 2 is started by the control module 22; the control module 22 controls the micro control valve 17 on each microchannel 16 to open and adjusts the output flow of the micro pump 21 so that the liquid in each storage chamber 13 flows into the micro mixing channel 14 in a set ratio; after the liquid is fully mixed in the micro mixing channel 14, it enters the outlet chamber 15 and enters the external infusion pipeline through the outlet interface 41 and the sealing joint 42 to achieve continuous, stable and precise infusion; (5) Process monitoring and abnormal handling: During the infusion process, the liquid balance, infusion flow rate and chip temperature of each liquid storage chamber 13 can be observed in real time through the display screen 221; when abnormal flow rate, excessive temperature or insufficient liquid balance occurs, the control module 22 will automatically prompt, and the operator can pause, adjust or stop the infusion through the operation button 222. (6) End of infusion and device disposal: After the infusion is completed, the drive component 2 and the temperature control component 3 are turned off by the control module 22, and the sealing joint 42 is disconnected from the external infusion pipeline. This device can be used for single use or reused after being disinfected according to medical standards, and it should be disposed of in accordance with the medical waste disposal standards after use.
[0026] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the invention, such designs should fall within the protection scope of the present invention.
Claims
1. A multi-chamber microfluidic chip-level ready-to-use infusion device, characterized in that, It includes a microfluidic chip body (1), a driving component (2), a temperature control component (3), and a connecting component (4); The microfluidic chip body (1) includes a cover plate (11) and a chip substrate (12). The cover plate (11) and the chip substrate (12) are sealed together to form a closed chamber structure. At least two independent liquid storage chambers (13), a micro-mixing channel (14) and an outlet chamber (15) are provided on the chip substrate (12). Each liquid storage chamber (13) is connected to the input end of the micro-mixing channel (14) through an independent micro-channel (16). The output end of the micro-mixing channel (14) is connected to the outlet chamber (15). Each micro-channel (16) is provided with a micro control valve (17) for controlling the flow channel opening and closing and the flow rate. The top of the liquid storage chamber (13) is provided with a liquid inlet (18) that penetrates the chip substrate (12). The liquid inlet (18) is provided with a removable sealing plug (19). The drive assembly (2) includes a micropump (21) and a control module (22). The micropump (21) is connected to each of the liquid storage chambers (13) to provide precise driving force for the liquid in the liquid storage chambers (13). The control module (22) is electrically connected to the micropump (21) and the micro control valve (17) to control the output flow of the micropump (21) and the on / off state of the micro control valve (17). The temperature control component (3) includes a heating element (31) and a temperature sensor (32). The heating element (31) is attached to the top of the chip substrate (12). The temperature sensor (32) is embedded in the chip substrate (12) and located near the liquid storage chamber (13). The temperature sensor (32) is electrically connected to the control module (22). The control module (22) adjusts the heating power of the heating element (31) according to the detection signal of the temperature sensor (32). The connecting component (4) includes a liquid outlet (41), which is disposed on the cover plate (11) and communicates with the liquid outlet chamber (15). The liquid outlet (41) is used to seal and connect with an external infusion pipeline.
2. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The number of liquid storage chambers (13) is 2-4, and the volume of each liquid storage chamber (13) is 10-100μL. The inner wall of each liquid storage chamber (13) is covered with a hydrophilic layer, which is a silica layer or a polyethylene glycol modified layer.
3. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The micro-mixing channel (14) adopts a spiral structure with an inner diameter of 0.5-2 mm. The width of the micro-channel (16) is 10-50 μm and the depth is 5-20 μm. The connection between the micro-channel (16) and the micro-mixing channel (14) adopts an arc-shaped transition structure.
4. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The micro control valve (17) is an electromagnetic control valve or a piezoelectric control valve. The control accuracy of the micro control valve (17) is not less than 0.1 μL / min and the response time is not more than 10 ms.
5. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The micropump (21) is a micro peristaltic pump or a piezoelectric micropump. The output flow rate of the micropump (21) is adjustable from 0.1 to 10 μL / min, and the flow rate accuracy is not less than ±0.05 μL / min.
6. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The temperature control component (3) has a temperature control range of 20-37℃ and a temperature control accuracy of not less than ±0.5℃. The heating element (31) is a flexible heating element that fits and covers the entire top of the chip substrate (12).
7. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, Both the cover plate (11) and the chip substrate (12) are made of biocompatible materials, such as polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), or glass.
8. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The connecting assembly (4) also includes a sealing connector (42), the liquid outlet (41) is threadedly connected to the sealing connector (42), the other end of the sealing connector (42) is provided with a Luer interface adapted to the external infusion pipeline, and the sealing connector (42) is provided with a sealing ring.
9. The multi-chamber microfluidic chip-level instant infusion device according to claim 1, characterized in that, The control module (22) is equipped with an independent display screen (221) and operation buttons (222). The display screen (221) is used to display the liquid balance, infusion flow rate and chip temperature of each of the liquid storage chambers (13). The display screen (221) is powered by an internal battery. The display screen (221) has a charging interface (223) on the side of its casing. The operation buttons (222) are used to set infusion parameters and start / stop infusion.
10. The multi-chamber microfluidic chip-level ready-to-use infusion device according to any one of claims 1-9, characterized in that, The microfluidic chip body (1) has a size of 20-50mm×20-50mm×1-5mm, and the overall device weighs no more than 50g.