Cryoprecipitate preparation instrument

Abstract

The invention relates to the technical field of plasma preparation equipment, and discloses a cryoprecipitate preparation instrument. The preparation module is used for accommodating the frozen plasma bag and the transfer bag, and the transfer bag is communicated with the frozen plasma bag through a catheter; the water supply system communicates with the preparation module; the peristaltic module is arranged corresponding to the conduit, and the conduit is at least partially fixed on the peristaltic module; the control system is electrically connected with the preparation module, the water supply system and the peristaltic module; the control system is used for controlling the water supply system to provide water at a preset temperature for the preparation module so as to melt the plasma in the frozen plasma bag; under the condition that the drainage preset condition is met, the peristaltic module is controlled to act on the catheter, so that the plasma in the frozen plasma bag is transferred to the transfer bag through the catheter. Through the arrangement, automatic water supply, melting and plasma transfer can be realized, so that the continuity and the preparation efficiency of a preparation process are ensured, and the consistency and the controllability of preparation conditions of different blood bags can be ensured.

Description

Technical Field

[0001] This application relates to the field of plasma preparation equipment technology, such as a cryoprecipitate preparation apparatus. Background Technology

[0002] Cryoprecipitate is an insoluble precipitate rich in clotting factors that forms after fresh frozen plasma is thawed in a low-temperature water bath. It is an important component in clinical blood transfusions and the preparation of blood products. Traditional cryoprecipitate preparation relies heavily on manual labor or semi-automatic equipment, which is cumbersome, inefficient, and suffers from problems such as cross-contamination between blood bags, insufficient temperature control precision, and poor process traceability. With the expansion of blood bank and clinical blood use and the improvement of quality control standards, achieving full automation, standardization, and safety in cryoprecipitate preparation has become an important requirement for the industry's development.

[0003] In related technologies, some cryoprecipitate preparation devices already employ a combination of water bath melting and gravity or simple pump suction for plasma transfer. These devices typically include a melting tank to hold the blood bags, a refrigeration system, piping, and collection bags. The frozen plasma is melted by controlling the water temperature, and then the thawed plasma is introduced into the transfer bag using a drop or peristaltic pump to ultimately obtain the cryoprecipitate component.

[0004] In the process of implementing the embodiments of this disclosure, at least the following problems were found in the related art: In related technologies, existing cryoprecipitate preparation equipment lacks sufficient automation and intelligence. Its water supply, melting, and plasma transfer processes are independent of each other and rely on manual judgment and operation, resulting in a discontinuous preparation process, low efficiency, and difficulty in ensuring the consistency and controllability of preparation conditions between different blood bags.

[0005] It should be noted that the information disclosed in the background section above is only used to enhance the understanding of the background of this application, and therefore may include information that does not constitute prior art known to those skilled in the art. Summary of the Invention

[0006] To provide a basic understanding of some aspects of the disclosed embodiments, a brief summary is given below. This summary is not intended as a general commentary, nor is it intended to identify key / important components or describe the scope of protection of these embodiments, but rather as a prelude to the detailed description that follows.

[0007] This disclosure provides a cryoprecipitate preparation apparatus that can automate water supply, melting, and plasma transfer to ensure the continuity and efficiency of the preparation process, and to guarantee the consistency and controllability of preparation conditions between different blood bags.

[0008] This disclosure provides a cryoprecipitate preparation apparatus comprising: a preparation module, a water supply system, a peristaltic module, and a control system. The preparation module is used to accommodate frozen plasma bags and transfer bags, with the transfer bags and frozen plasma bags connected via conduits. The water supply system is connected to the preparation module. The peristaltic module is positioned corresponding to the conduits, with the conduits at least partially fixed to the peristaltic module. The control system is electrically connected to the preparation module, the water supply system, and the peristaltic module. The control system controls the water supply system to provide water at a preset temperature to the preparation module to thaw the plasma in the frozen plasma bags. Under preset drainage conditions, the control system controls the peristaltic module to act on the conduits, transferring the plasma in the frozen plasma bags to the transfer bags via the conduits.

[0009] In some embodiments, the preparation module includes: a water tank, a melting frame, and a transfer box. The water tank is connected to a water supply system; the melting frame is used to hold frozen plasma bags and is located above the water tank; the transfer box is used to hold transfer bags; wherein the melting frame is at least partially located inside the water tank; the control system is used to control the water supply system to provide water at a preset temperature to the preparation module, including: the control system is used to control the water supply system to deliver water at a preset temperature to the water tank.

[0010] In some embodiments, the water supply system includes a chilled water tank and a collection water tank. The chilled water tank is connected to the inlet of the water tank and is used to supply water at a preset temperature to the water tank; the collection water tank is connected to the outlet of the water tank and is used to collect water discharged from the water tank.

[0011] In some embodiments, the water tank includes a first outlet and a second outlet, with the first outlet positioned lower than the second outlet. The water supply system also includes an outlet pipe and an overflow pipe. The outlet pipe connects the first outlet to the collection tank; the overflow pipe connects the second outlet to the collection tank.

[0012] In some embodiments, the water supply system further includes an inlet solenoid valve and an outlet solenoid valve. The inlet solenoid valve is disposed at the inlet of the water tank; the outlet solenoid valve is disposed at the first outlet of the water tank; wherein, the control system is electrically connected to the inlet solenoid valve and the outlet solenoid valve respectively to control the opening and closing of the inlet solenoid valve and the outlet solenoid valve.

[0013] In some embodiments, the control system for controlling the water supply system to deliver water at a preset temperature to the water tank includes: controlling the opening of the inlet solenoid valve and the outlet solenoid valve; wherein the opening degree of the outlet solenoid valve is less than or equal to the opening degree of the inlet solenoid valve.

[0014] In some embodiments, the cold precipitation preparation apparatus includes multiple preparation modules and multiple peristaltic modules; wherein the multiple peristaltic modules and multiple preparation modules are configured in a one-to-one correspondence.

[0015] In some embodiments, the water supply system further includes a pressure equalization tank. The pressure equalization tank includes an inlet and multiple outlets, the inlet being connected to a cooling water tank, and the multiple outlets being connected to water tanks of multiple preparation modules respectively.

[0016] In some embodiments, the pre-defined conditions for diversion include: the time for the water supply system to provide water at a preset temperature to the preparation module is greater than or equal to a preset time.

[0017] In some embodiments, the cryoprecipitate preparation apparatus further includes a weighing component. The weighing component is used to obtain the weights of the frozen plasma bags and transfer bags, respectively; the control system is also electrically connected to the weighing component to control the cryoprecipitate preparation apparatus to run a preset preparation program based on the weights of the frozen plasma bags and transfer bags.

[0018] In some embodiments, the preset preparation procedure includes: controlling the preparation module to transfer a preset weight of plasma according to the weight of the frozen plasma bag; wherein the weight of the transferred plasma is proportional to the weight of the frozen plasma bag.

[0019] In some embodiments, when the weight of the transferred plasma reaches a preset weight, the peristaltic module is controlled to block the catheter.

[0020] The cold precipitation preparation apparatus provided in this disclosure can achieve the following technical effects: This disclosure provides a cryoprecipitate preparation apparatus comprising: a preparation module, a water supply system, a peristaltic module, and a control system. The preparation module is used to accommodate frozen plasma bags and transfer bags, with the transfer bags connected to the frozen plasma bags via conduits. The water supply system is connected to the preparation module. The peristaltic module is positioned corresponding to the conduits, and the conduits are at least partially fixed to the peristaltic module. The control system is electrically connected to the preparation module, the water supply system, and the peristaltic module. The control system controls the water supply system to provide water at a preset temperature to the preparation module to thaw the plasma in the frozen plasma bags. Under preset drainage conditions, the control system controls the peristaltic module to act on the conduits, transferring the plasma in the frozen plasma bags to the transfer bags via the conduits. Thus, frozen plasma bags containing frozen plasma and empty transfer bags are placed in corresponding positions within the preparation module, connected by conduits. The control system activates the water supply system to provide and maintain water at a preset temperature to the preparation module area containing the frozen plasma bags, initiating the ice bath thawing process. Then, the control system controls the peristaltic module to apply force to the conduits, pumping the thawed liquid plasma from the frozen plasma bags into the transfer bags via the conduits. This setup enables automated water supply, melting, and plasma transfer, ensuring the continuity and efficiency of the preparation process, and guaranteeing the consistency and controllability of preparation conditions between different blood bags.

[0021] The above general description and the description below are exemplary and illustrative only and are not intended to limit this application. Attached Figure Description

[0022] One or more embodiments are illustrated by way of example with reference to the accompanying drawings. These illustrations and drawings do not constitute a limitation on the embodiments. Elements having the same reference numerals in the drawings are shown as similar elements. The drawings are not to be scaled. And wherein: Figure 1 This is a schematic diagram of a cold precipitation preparation apparatus provided in an embodiment of this disclosure; Figure 2 This is a schematic diagram of another cold precipitation preparation apparatus provided in an embodiment of this disclosure; Figure 3 This is a schematic diagram of the structure of a preparation module provided in an embodiment of this disclosure; Figure 4 This is a schematic diagram of the structure of a peristaltic module provided in an embodiment of this disclosure; Figure 5 This is a schematic diagram of another peristaltic module provided in an embodiment of this disclosure; Figure 6 This is a schematic diagram of a water supply system provided in an embodiment of this disclosure; Figure 7 This is a schematic diagram of another water supply system provided in an embodiment of this disclosure; Figure 8 This is a schematic diagram of the structure of a blood bag provided in an embodiment of this disclosure.

[0023] Figure label: 11: Chassis; 21: Frozen plasma bag; 22: Transfer bag; 23: Catheter; 30: Preparation module; 31: Water tank; 32: Melting frame; 33: Transfer box; 34: Partition; 40: Water supply system; 411: Cooling water tank; 412: Collection tank; 413: Pressure equalizing tank; 421: Distribution pipeline; 422: Outlet pipe; 423: Overflow pipe; 424: Water supply pipeline; 431: Inlet solenoid valve; 432: Outlet solenoid valve; 433: Water supply solenoid valve; 44: Water pump; 50: Peristaltic module; 51: Peristaltic device; 511: Drive motor; 512: Peristaltic slider; 513: Transmission mechanism; 514: Pump frame; 515: Drive pulley; 516: Driven pulley; 52: Drive module; 53: Clamping mechanism; 531: First push rod; 532: Second push rod; 533: Push plate; 60: Weighing components; 70: Integrated operating platform; 71: Re-weighing component; 72: Barcode scanning module; 73: Heat sealing module; 74: Display device; 75: Disinfection component; 76: Lighting component. Detailed Implementation

[0024] To provide a more detailed understanding of the features and technical content of the embodiments of this disclosure, the implementation of the embodiments of this disclosure will be described in detail below with reference to the accompanying drawings. The accompanying drawings are for illustrative purposes only and are not intended to limit the embodiments of this disclosure. In the following technical description, for ease of explanation, several details are used to provide a full understanding of the disclosed embodiments. However, one or more embodiments may still be implemented without these details. In other cases, well-known structures and devices may be simplified in their depiction to simplify the drawings.

[0025] The terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this disclosure are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate for the embodiments of this disclosure described herein. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion.

[0026] In this disclosure, the terms "upper," "lower," "inner," "middle," "outer," "front," and "rear," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for better description of the embodiments of this disclosure and their implementations, and are not intended to limit the indicated devices, elements, or components to having a specific orientation, or to require them to be constructed and operated in a specific orientation. Furthermore, some of the aforementioned terms may be used to indicate other meanings besides orientation or positional relationship; for example, the term "upper" may in some cases indicate a dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in the embodiments of this disclosure according to the specific circumstances.

[0027] Furthermore, the terms "set up," "connect," and "fix" should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be an internal connection between two devices, components, or parts. Those skilled in the art can understand the specific meaning of the above terms in the embodiments of this disclosure according to the specific circumstances.

[0028] Unless otherwise stated, the term "multiple" means two or more.

[0029] In this embodiment of the disclosure, the character " / " indicates that the objects before and after it are in an "or" relationship. For example, A / B means: A or B.

[0030] The term "and / or" describes an association between objects, indicating that three relationships can exist. For example, A and / or B means: A or B, or A and B.

[0031] It should be noted that, unless otherwise specified, the embodiments and features described in the present disclosure can be combined with each other.

[0032] like Figures 1 to 8 As shown in the embodiments of this disclosure, a cryoprecipitate preparation apparatus is provided, which can realize automated water supply, melting and plasma transfer to ensure the continuity and efficiency of the preparation process, and can ensure the consistency and controllability of preparation conditions between different blood bags.

[0033] like Figures 1 to 8 As shown, this embodiment of the present disclosure provides a cryoprecipitate preparation apparatus including: a preparation module 30, a water supply system 40, a peristaltic module 50, and a control system. The preparation module 30 is used to accommodate a frozen plasma bag 21 and a transfer bag 22, respectively, and the transfer bag 22 is connected to the frozen plasma bag 21 via a conduit 23; the water supply system 40 is connected to the preparation module 30; the peristaltic module 50 is disposed corresponding to the conduit 23, and the conduit 23 is at least partially fixed to the peristaltic module 50; the control system is electrically connected to the preparation module 30, the water supply system 40, and the peristaltic module 50 respectively; the control system is used to control the water supply system 40 to provide water at a preset temperature to the preparation module 30 to thaw the plasma in the frozen plasma bag 21; under the condition of meeting the preset drainage conditions, the control system controls the peristaltic module 50 to act on the conduit 23, so that the plasma in the frozen plasma bag 21 is transferred to the transfer bag 22 through the conduit 23.

[0034] Specifically, the preparation module 30 has preparation and placement areas adapted to two types of blood bags. One preparation and placement area is used to accommodate frozen plasma bags 21. This area needs to have a certain height space and an anti-slip design at the bottom to prevent the blood bags from shifting during the preparation process. The other preparation and placement area is used to accommodate transfer bags 22, which can be placed lower than the preparation and placement area of ​​the frozen plasma bags 21. The two ends of the conduit 23 are respectively sealed to the outlet of the frozen plasma bag 21 and the inlet of the transfer bag 22 to eliminate the risk of leakage. A section needs to be reserved in the middle of the conduit 23 to be fixed to the peristaltic module 50. The outer wall of the conduit 23 in this area needs to be smooth and wrinkle-free to ensure that the force of the peristaltic module 50 can be evenly transmitted to the fluid in the tube. The water supply system 40 has built-in cooling components and temperature monitoring components. When the water temperature is higher than the preset temperature, the control system triggers the cooling components to start and continuously cool. When the water temperature is lower than the preset temperature, the cooling components stop operating, maintaining the water temperature stable within the target range through a "start-stop cycle". This temperature control logic avoids both excessively high water temperatures that could inactivate clotting factors in the plasma and excessively low water temperatures that could slow down plasma melting and affect preparation efficiency. The peristaltic module 50 has a groove on its surface that matches the outer diameter of the catheter 23, allowing the catheter 23 to engage with it. Simultaneously, the groove length must cover the critical area where the catheter 23 contacts the module; for example, a groove length of 5-8 cm ensures even distribution of the force exerted by the module on the catheter 23, preventing excessive local compression that could cause the catheter 23 to rupture. The peristaltic module 50 periodically squeezes and releases this section of the catheter 23 through its internal rollers or pressure blocks, thereby generating a peristaltic pumping action to drive or precisely control the flow of liquid within the catheter 23.

[0035] When cryoprecipitate preparation is required, the operator installs the blood bag into the preparation module 30 and starts the program via the control system. The control system first commands the water supply system 40 to start working, delivering constant-temperature water at a preset temperature to the preparation module 30. The frozen plasma bag 21 in the preparation module 30 begins to thaw gradually under this constant-temperature environment. The control system continuously monitors the process throughout the thawing. When the control system determines that the current state meets the preset drainage conditions, it controls the peristaltic module 50 to start working, applying force to the fixed conduit 23. Driven by the peristaltic pump, the thawed plasma in the frozen plasma bag 21 is pumped through the conduit 23 to the transfer bag 22. The transfer process continues until the control system determines that the transfer is complete, then stops the peristaltic module 50. At this point, the main preparation process is complete, leaving cryoprecipitate in the frozen plasma bag 21. This setup enables automated water supply, thawing, and plasma transfer, ensuring the continuity and efficiency of the preparation process, and guaranteeing the consistency and controllability of preparation conditions between different blood bags.

[0036] In the above embodiments, the preset temperature can be set according to the user's actual needs. Specifically, the preset temperature can be greater than or equal to 0°C and less than or equal to 10°C, for example, the preset temperature can be 0°C, 2°C, 4°C, 6°C, 8°C or 10°C.

[0037] Optionally, the pipe diameter of the water supply system 40 needs to match the water flow rate to ensure that the water flow can evenly cover the melting area of ​​the frozen plasma bag 21. At the same time, the delivery unit of the water supply system 40 has a built-in small water pump 44 to provide stable water pressure and avoid water flow impact on the blood bag due to water pressure fluctuations, which could cause the bag to break. In addition, a one-way valve is provided at the end of the pipe to prevent water in the preparation module 30 from flowing back into the water supply system 40 and avoid cross-contamination.

[0038] In some embodiments, the preparation module 30 includes: a water tank 31, a melting frame 32, and a transfer box 33. The water tank 31 is connected to a water supply system 40; the melting frame 32 is used to accommodate a frozen plasma bag 21 and is located above the water tank 31; the transfer box 33 is used to accommodate a transfer bag 22; wherein the melting frame 32 is at least partially located within the water tank 31; the control system is used to control the water supply system 40 to provide water at a preset temperature to the preparation module 30, including: the control system is used to control the water supply system 40 to deliver water at a preset temperature to the water tank 31.

[0039] Specifically, the water tank 31 is a container with a cavity for holding a constant-temperature liquid, creating a direct water bath environment for thawing the blood bags. The water tank 31 has an inlet and an outlet, connected to the water supply system 40 via the inlet to receive temperature-controlled water from the system. The thawing frame 32 is used to support and secure the frozen plasma bag 21, which is placed above the water tank 31, and its bottom or sidewalls allow at least partial immersion of the bag in the water below. In this way, the frozen plasma bag 21 is surrounded by constant-temperature water, achieving uniform and controlled thawing. The transfer box 33 is used to support and secure the transfer bag 22, and is independently configured to reliably receive the plasma liquid separated from the frozen plasma bag 21. The water supply system 40 delivers constant temperature water at a preset temperature to the water tank 31; the melting frame 32 containing the frozen plasma bag 21 is partially immersed in the constant temperature water in the water tank 31, causing the blood bag to begin melting; the transfer box 33 containing the transfer bag 22 is placed independently and is connected to the frozen plasma bag 21 through the conduit 23; the control system controls the water supply system 40 to deliver and maintain constant temperature water in the water tank 31, so as to control the water supply system 40 to provide water at a preset temperature to the preparation module 30.

[0040] In some embodiments, the water supply system 40 includes a chilled water tank 411 and a collection water tank 412. The chilled water tank 411 is connected to the inlet of the water tank 31 and is used to provide water at a preset temperature to the water tank 31; the collection water tank 412 is connected to the outlet of the water tank 31 and is used to receive water discharged from the water tank 31.

[0041] Specifically, the chilled water tank 411 is the refrigeration component and water storage unit of the water supply system 40, used to prepare and store chilled water at a preset temperature. The chilled water tank 411 cools the injected room-temperature water, and a temperature sensor and control circuit ensure that the water temperature is accurately maintained within the required range. The chilled water tank 411 includes a compressor and an evaporator, which can cool the incoming room-temperature water to the preset temperature; the temperature sensor uses a high-precision platinum resistance temperature sensor to collect water supply temperature data in real time and feed it back to the control system. The outlet of the chilled water tank 411 is directly connected to the inlet of the water tank 31 via a pipe. When water supply is needed, the low-temperature water in the chilled water tank 411 is pumped or pressurized to the water tank 31 to provide a constant temperature environment for blood bag melting. The collecting water tank 412 is used to receive and temporarily store used water discharged from the water tank 31. The inlet of the collecting water tank 412 is connected to the outlet of the water tank 31 via a pipe. After completing the water bath function, the water in the water tank 31 is discharged into the collection tank 412 by gravity or pump suction.

[0042] In some embodiments, the water tank 31 includes a first water outlet and a second water outlet, with the first water outlet positioned lower than the second water outlet. The water supply system 40 also includes an outlet pipe 422 and an overflow pipe 423. The outlet pipe 422 connects the first water outlet to the collection tank 412; the overflow pipe 423 connects the second water outlet to the collection tank 412.

[0043] Specifically, the water tank 31 is provided with a first outlet and a second outlet, with the first outlet positioned lower than the second outlet. A drain pipe 422 connects the lower-positioned first outlet to the collection tank 412, serving as an active drainage channel. An overflow pipe 423 connects the higher-positioned second outlet to the collection tank 412, serving as a safe overflow channel for the water level in the water tank 31. When the control system controls the water supply system 40 to inject constant-temperature water into the water tank 31, the water level in the water tank 31 begins to rise. Initially, the water level is lower than the higher second outlet, and water is discharged only from the lower-positioned first outlet through the drain pipe 422. If the water injection rate is greater than the drainage rate, the water level will continue to rise. When the water level rises to the same height as the second outlet, excess water will naturally flow out from the overflow pipe 423. At this point, the water level in the water tank 31 will be stably maintained at the height of the second outlet and will not continue to rise, forming a dynamic equilibrium: the injected water volume is equal to the combined water volume discharged from the first and second outlets. In this way, without the need for complex sensors and feedback control, the water level in each tank 31 can be kept constant and consistent during the melting process using only a simple physical structure.

[0044] In some embodiments, the water supply system 40 further includes an inlet solenoid valve 431 and an outlet solenoid valve 432. The inlet solenoid valve 431 is disposed at the inlet of the water tank 31; the outlet solenoid valve 432 is disposed at the first outlet of the water tank 31; wherein, the control system is electrically connected to the inlet solenoid valve 431 and the outlet solenoid valve 432 respectively to control the opening and closing of the inlet solenoid valve 431 and the outlet solenoid valve 432.

[0045] Specifically, the inlet solenoid valve 431 is installed at the inlet of the water tank 31, located between the water supply pipe 424 and the inlet of the water tank 31, and is used to control the supply of constant temperature water to the water tank 31. The outlet solenoid valve 432 is installed at the first outlet of the water tank 31, located between the first outlet of the water tank 31 and the outlet pipe 422, and is used to control the active drainage of water in the water tank 31.

[0046] In some embodiments, the control system for controlling the water supply system 40 to deliver water at a preset temperature to the water tank 31 includes: controlling the opening of the inlet solenoid valve 431 and the outlet solenoid valve 432; wherein the opening degree of the outlet solenoid valve 432 is less than or equal to the opening degree of the inlet solenoid valve 431.

[0047] Specifically, by making the opening of the outlet solenoid valve 432 less than or equal to the opening of the inlet solenoid valve 431, the instantaneous inflow of water into the tank 31 can be greater than or equal to the instantaneous outflow. When the inflow exceeds the outflow, the water level in the tank 31 will rise. The rising water level will eventually overflow from the higher-positioned second outlet, thus achieving dynamic equilibrium and stabilizing the water level at the overflow height. Even after water level equilibrium is achieved, because both valves remain open, low-temperature water continues to be injected, and relatively warmer water in the tank continues to be discharged from the first outlet. Excess water overflows from the overflow outlet, creating a continuous, slow water flow renewal and circulation within the tank. This circulation avoids localized temperature increases, thus ensuring consistent melting conditions for the blood bags. Furthermore, compared to passive drainage relying entirely on the overflow pipe, this active valve opening control strategy gives the system stronger regulatory capabilities. For example, during the initial water injection phase, a larger opening difference can be set to quickly establish the water level; during the maintenance phase, the opening can be adjusted to near equality, achieving more energy-efficient micro-circulation. All processes are completed automatically by the control system without human intervention.

[0048] In some embodiments, the cold precipitation preparation apparatus includes a plurality of preparation modules 30 and a plurality of peristaltic modules 50; wherein the plurality of peristaltic modules 50 and the plurality of preparation modules 30 are arranged in a one-to-one correspondence.

[0049] Specifically, each preparation module 30 includes, as described above, a water tank 31, a melting frame 32, a transfer box 33, and matching inlet solenoid valve 431, outlet solenoid valve 432, and piping. Multiple peristaltic modules 50 are configured in a one-to-one correspondence with multiple preparation modules 30. This means that each independent preparation module 30 is equipped with a corresponding peristaltic module 50. Thus, multiple preparation modules 30 allow for the simultaneous placement and processing of multiple blood bags. Each module is an independent working unit, enabling the instrument to prepare multiple samples of cryoprecipitate simultaneously, greatly improving the overall processing efficiency and output capacity of the equipment.

[0050] Optionally, if the cold precipitation preparation apparatus includes multiple preparation modules 30, each preparation module 30's water tank 31 is equipped with an independent set of inlet and outlet solenoid valves 432. This allows the control system to control the water supply and drainage of any one water tank 31 independently without interfering with other modules. For example, the water supply to a certain water tank 31 can be started independently to begin preparation, or a water tank 31 that has completed its task can be emptied independently.

[0051] In some embodiments, the water supply system 40 further includes a pressure equalization tank 413. The pressure equalization tank 413 includes an inlet end and multiple outlet ends, the inlet end being connected to the cooling water tank 411, and the multiple outlet ends being respectively connected to the water tanks 31 of the multiple preparation modules 30.

[0052] Specifically, the equalizing water tank 413 is located downstream of the cooling water tank 411 and upstream of the preparation module 30. In the case where the cryoprecipitation preparation apparatus includes multiple preparation modules 30, the inlet is connected to the cooling water tank 411 via a pipeline to receive constant-temperature chilled water from the cooling water tank 411, and multiple outlets are connected to the inlets of the water tanks 31 in the corresponding preparation modules 30 via independent pipelines. The internal cavities of the equalizing water tank 413 are interconnected. When water from the cooling water tank 411 is pumped into the equalizing water tank 413, the water diffuses freely within the tank and reaches pressure equilibrium. This ensures that the static and dynamic pressures at the source of the water flowing out from each outlet of the equalizing water tank 413 remain essentially consistent, thus providing a balanced water supply pressure basis for each downstream water tank 31. Under the premise of balanced water supply pressure, even if multiple preparation modules 30 start the water injection process simultaneously, the water flow velocity through each parallel branch can remain highly consistent. This ensures that the water injection speed and volume of each water tank 31 are controllable and identical. In addition, when the water supply of some preparation modules 30 stops due to valve closure, it will not cause a severe impact on the pipeline pressure of other modules that are using water. The overall water pressure of the system remains stable, thereby ensuring the stability of the water flow of the remaining working modules.

[0053] In some embodiments, the horizontal height of the connection between the multiple water distribution pipes 421 and the pressure equalization tank 413 is the same to avoid static pressure differences at the inlet ends of the multiple water distribution pipes 421.

[0054] Specifically, the connection points of the multiple water distribution pipes 421 to the equalizing water tank 413, i.e., the inlet ports of each pipe, are set at the same horizontal height. According to the principle of fluid statics, the static pressure is different at different depths in a connected liquid. Therefore, if the inlet heights of the water distribution pipes 421 on the side wall of the equalizing water tank 413 are different, then even if the internal pressure of the equalizing water tank 413 is the same, the water depth at different inlets will produce different static pressure superpositions. The inlets at lower positions will bear greater static water pressure. By making all inlets at the same horizontal height, it is ensured that the water distributed from the equalizing water tank 413 to each water distribution pipe 421 carries a consistent total pressure, thereby eliminating the systematic pressure deviation introduced by differences in structural installation.

[0055] In some embodiments, the water supply system 40 further includes a pressure sensor. The pressure sensor is used to acquire the internal pressure of the equalizing water tank 413; the control system is also used to adjust the operating state of the water pump 44 according to the internal pressure of the equalizing water tank 413, so as to maintain the internal pressure of the equalizing water tank 413 within a preset pressure range.

[0056] Specifically, a pressure sensor is installed to acquire the internal pressure value of the equalizing tank 413 in real time. The control system is configured to receive pressure data from the pressure sensor and dynamically adjust the operating state of the water pump 44 based on the measured internal pressure value of the equalizing tank 413 to stably maintain the internal pressure of the equalizing tank 413 within a preset pressure range. In this way, the pressure sensor continuously detects the pressure; the control system compares the detected value with the preset range; and then compensates for pressure deviations by adjusting the power of the water pump 44. This allows the system to proactively respond to pressure disturbances caused by changes in water consumption, achieving dynamic equilibrium, rather than relying solely on the passive buffering of the equalizing tank 413 structure.

[0057] In some embodiments, the control system is further configured to adjust the operating state of the water pump 44 according to the internal pressure of the equalizing water tank 413, including: increasing the power or speed of the water pump 44 when the internal pressure of the equalizing water tank 413 is less than the lower limit of the preset pressure range; decreasing the power or speed of the water pump 44 when the internal pressure of the equalizing water tank 413 is greater than the upper limit of the preset pressure range; or controlling the water pump 44 to stop.

[0058] Specifically, when multiple preparation modules 30 simultaneously open the water supply solenoid valve 433 in their water tanks, the system's water flow demand increases. If the output of the water pump 44 remains unchanged, the pressure in the equalizing water tank 413 tends to decrease. At this time, the pressure sensor immediately detects the pressure drop and its proximity to or below the lower limit of the preset range. The control system then increases the power or speed of the water pump 44 to increase the water supply and restore the tank pressure. Conversely, when the number of water-using modules decreases, the system automatically reduces the power of the water pump 44 to prevent excessive pressure. This ensures that regardless of the number of water tanks 31 operating simultaneously, the water supply pressure at the outlet of each open water distribution pipe 421 remains stable, thereby guaranteeing that the water filling conditions of each water tank 31 are strictly consistent.

[0059] In practical applications, the above-mentioned preset pressure range can be set according to the user's actual needs.

[0060] In some embodiments, the water supply system 40 further includes: a plurality of first liquid level sensors. The plurality of first liquid level sensors are respectively disposed on a plurality of water tanks 31 for obtaining the water level in the water tanks 31; the control system is further configured to control the opening and closing of the corresponding water supply solenoid valve 433 according to the water level in the water tanks 31, so as to maintain the water level in the water tanks 31 at a preset water level.

[0061] Specifically, the number of first liquid level sensors corresponds one-to-one with the number of water tanks 31. Each first liquid level sensor is installed in a corresponding water tank 31 to obtain the water level data in the tank 31 in real time and accurately. Specifically, the control system is electrically connected to each first liquid level sensor and continuously receives the real-time water level information of each water tank 31. For each water tank 31, the system has a preset target water level value. Based on the real-time water level in each water tank 31, the control system independently controls the opening or closing of the water supply solenoid valve 433 on the water distribution pipe 421 connected to that water tank 31, thereby maintaining the water level in each water tank 31 at its respective preset water level. Thus, when the water level in any water tank 31 is lower than the preset value, its first liquid level sensor sends a signal, and the control system immediately opens the corresponding water supply solenoid valve 433, using the stable pressure provided by the equalizing water supply system 40 to fill the water tank 31 with water; when the water level in the water tank 31 reaches the preset value, the solenoid valve is closed, and water filling stops. By independently maintaining the water level of each tank 31 at the same preset height, the immersion depth and water bath environment of all blood bags are ensured to be completely consistent, eliminating water level differences caused by manual water injection or simple time control.

[0062] In practical applications, since the water level of each tank 31 can be maintained independently, different tanks 31 can start or stop the preparation process independently. For example, after a new blood bag is placed in any empty tank 31, that tank 31 can immediately start the water filling program to the preset water level without waiting for other tanks 31, which better supports the automation requirements of multi-module parallel and time-sharing operation.

[0063] In this application, the water supply solenoid valve 433 and the water inlet solenoid valve 431 can be a single solenoid valve or two independent solenoid valves.

[0064] In some embodiments, the water supply system 40 further includes a second liquid level sensor. The second liquid level sensor is disposed in the collection tank 412 and is used to obtain the water level in the collection tank 412; the control system is also used to adjust the power or speed of the water pump 44 according to the water level in the collection tank 412 so that the water supply pressure of the equalizing tank 413 matches the recovery pressure of the collection tank 412.

[0065] Specifically, a second liquid level sensor is installed inside the collecting tank 412 to obtain real-time and accurate water level data within the collecting tank 412. The control system is electrically connected to the second liquid level sensor and continuously receives real-time water level information from the collecting tank 412. The control system also dynamically adjusts the power or speed of the water pump 44 based on changes in the water level within the collecting tank 412 to dynamically match the supply pressure of the equalizing tank 413 with the recovery pressure of the collecting tank 412. In essence, the water level in the collecting tank 412 directly reflects the load status of the drainage system. A high water level in the collecting tank 412 indicates a large drainage volume or fast drainage speed, and there may be back pressure in the drainage pipeline. By monitoring the water level in the collecting tank 412, the control system can predict or sense pressure changes at the drainage end. For example, when multiple water tanks 31 simultaneously drain large amounts of water, causing the water level in the collection tank 412 to rise rapidly, the system can appropriately reduce the power or speed of the water pump 44. This is because the drainage back pressure may increase at this time, and it is not necessary to maintain stable water filling in the water tanks 31 without excessively high water supply pressure. In fact, it is even necessary to prevent excessively high water supply pressure from causing difficulties in water filling. Conversely, when the water level in the collection tank 412 is very low, the system can appropriately increase the output of the water pump 44 to overcome the potentially lower drainage end resistance and ensure water supply efficiency. In this way, the energy waste and potential overload risk caused by the water pump 44 still operating at high power when drainage is not smooth are avoided, as is the problem of insufficient water supply pressure when drainage is smooth. This significantly improves the energy efficiency ratio and operating economy of the entire water circulation system.

[0066] In some embodiments, the pre-defined conditions for diversion include: the time for the water supply system 40 to provide water at a preset temperature to the preparation module 30 is greater than or equal to a preset time.

[0067] Specifically, the control system continuously compares the actual water supply time with a preset time threshold. When the actual water supply time is greater than or equal to the preset time, the control system determines that the drainage preset condition is met. The preset time can be set according to the user's actual needs. Specifically, the preset time is greater than or equal to 2 seconds, meaning that when the water system provides water at a preset temperature to the preparation module 30 for a time greater than or equal to 2 seconds, the control system determines that the drainage preset condition is met. The preset time can be 2 seconds, 4 seconds, 6 seconds, 8 seconds, or 10 seconds. In this way, by forcibly implementing a uniform melting time, the problem of decreased cold precipitation yield or quality caused by premature transfer of plasma due to insufficient melting can be effectively avoided. At the same time, after placing the blood bag, starting the water supply, and stabilizing the water level, the system only needs to wait a fixed time to automatically trigger the next peristaltic pump transfer action, without any manual intervention or visual inspection.

[0068] In the above embodiments, when the cold precipitation preparation instrument includes multiple preparation modules 30, each preparation module 30 can be set with an independent water supply timer. Different modules can start supplying water sequentially and independently trigger the transfer after reaching their preset time, supporting a parallel asynchronous working mode for multiple modules.

[0069] In some embodiments, the cryoprecipitate preparation apparatus further includes a weighing component 60. The weighing component 60 is used to obtain the weights of the frozen plasma bag 21 and the transfer bag 22, respectively; the control system is also electrically connected to the weighing component 60 to control the cryoprecipitate preparation apparatus to run a preset preparation program based on the weights of the frozen plasma bag 21 and the transfer bag 22.

[0070] Specifically, the weighing component 60 is used to separately and independently acquire the real-time weight of the frozen plasma bag 21 and the transfer bag 22. The control system is electrically connected to the weighing component 60 to receive the two weight signals in real time. The control system is configured to automatically control the cryoprecipitate preparation instrument to run the corresponding preset preparation program based on these two initial weight values. It is understood that traditional single-weighing systems require manual execution of complex operations such as tareing and differential calculation. In this embodiment, by simultaneously acquiring the initial weights of the upper and lower blood bags, the control system can automatically complete the necessary calculation benchmark settings. The operator only needs to place the blood bag in the designated position; the equipment automatically identifies the specifications based on the weight and prepares accordingly, greatly simplifying the operation.

[0071] In some embodiments, the preset preparation procedure includes: controlling the preparation module 30 to transfer a preset weight of plasma according to the weight of the frozen plasma bag 21; wherein the weight of the transferred plasma is proportional to the weight of the frozen plasma bag 21.

[0072] Specifically, the control system automatically determines the target plasma transfer weight required for this preparation based on the initial weight of the frozen plasma bag 21 obtained by the weighing component 60. This target weight is the amount of liquid plasma to be transferred from the frozen plasma bag 21 to the transfer bag 22. This target weight is proportional to the initial weight of the frozen plasma bag 21. For example, 100g of plasma corresponds to the preparation of 20g of cryoprecipitate, meaning approximately 80g of liquid plasma needs to be transferred; 150g corresponds to approximately 120g. During the plasma transfer process via the peristaltic module 50, the weighing component 60 operates continuously. The control system monitors this in real time, determining whether the transfer is complete based on the real-time transfer volume calculated from the weighing component 60. When the control system calculates and determines that the actual weight of plasma transferred to the transfer bag 22 has reached the target weight determined by the proportional relationship, i.e., after determining that the plasma weight has reached the preset weight, the peristaltic module 50 stops transferring plasma. This setup ensures that even if there are slight differences in the initial state of each bag of plasma, the final weight of the cryoprecipitate will strictly meet the preset standard, achieving optimization from process control to result control, and significantly improving product consistency and quality reliability.

[0073] In some embodiments, when the weight of the transferred plasma reaches a preset weight, the peristaltic module 50 is controlled to block the catheter 23.

[0074] Specifically, when the real-time feedback data from the weighing component 60 indicates that the cumulative weight of plasma transferred from the frozen plasma bag 21 to the transfer bag 22 has reached the preset target weight, the control system immediately blocks the flow of liquid in the catheter 23 to the peristaltic module 50 corresponding to the target preparation module 30. The peristaltic module 50 includes a clamping mechanism driven by an electric cylinder. During the normal pumping phase, this mechanism releases the catheter 23, subjecting it only to the action of the peristaltic rollers. Upon receiving the blocking command, the control system controls the electric cylinder to retract, driving the push rod and push plate 533 to move forward, firmly pressing the catheter 23 against a fixed surface of the module, thereby using mechanical force to completely close the flexible catheter 23 wall, forming a non-flowing physical blockage.

[0075] In some embodiments, the cryoprecipitate preparation apparatus further includes a housing 11 and an integrated operating platform 70. A preparation module 30 is disposed within the housing 11 and is used to accommodate frozen plasma bags 21. The integrated operating platform 70 is also disposed within the housing 11 and integrates a weighing assembly 71, a barcode scanning module 72, and a heat-sealing module 73. A control system is electrically connected to the preparation module 30 and the integrated operating platform 70. The control system controls the preparation module 30 to perform cryoprecipitate preparation on the frozen plasma bags 21 and controls the weighing assembly 71, the barcode scanning module 72, and the heat-sealing module 73 to collaboratively weigh, scan, and heat-seal the frozen plasma bags 21 after cryoprecipitate preparation.

[0076] In some embodiments, the weighing assembly 71 includes a weighing placement area provided with a weight sensor, the weight sensor being used to weigh the frozen plasma bags in the weighing placement area.

[0077] Specifically, the weighing assembly 71 includes a weighing placement area, and a weight sensor is disposed below or inside the weighing placement area. The weighing assembly 71 is used to accurately verify the weight of the frozen plasma bag 21 containing the final product (i.e., the blood bag that has undergone separation and has residual cryoprecipitate) after the cryoprecipitate preparation process is completed. The weighing placement area can be a fixed platform or groove for stably placing the blood bag to be weighed, ensuring consistent placement posture. The weight sensor is integrated below the weighing placement area or into the support structure. When the blood bag is placed in this area, its weight is accurately sensed by the sensor and converted into an electrical signal. The weight sensor can be a high-precision strain gauge sensor or an electromagnetic force sensor.

[0078] In the above embodiments, the weighing component 71 is different from the weighing component 60 that may be used for monitoring during the preparation process, but is used to confirm the quality of the final output.

[0079] In some embodiments, the barcode scanning module 72 includes an image acquisition device located above the weighing and placing area, and the field of view of the image acquisition device covers the weighing and placing area, so that the weighing component 71 and the barcode scanning module 72 work together to weigh and scan the frozen plasma bag 21.

[0080] In some embodiments, the cold precipitation preparation apparatus includes multiple integrated operating platforms 70, which are arranged opposite each other on both sides of the preparation module 30, and at least one integrated operating platform 70 is located in the middle of the housing 11.

[0081] In some embodiments, the integrated operating platform 70 further includes a display device 74. The display device 74 is provided with a human-machine interface; the control system is also used to control the human-machine interface to display weighing data, barcode scanning results, heat sealing status and equipment operating parameters in real time, and supports control of the cold precipitation preparation instrument via touch operation.

[0082] In some embodiments, the peristaltic module 50 includes a peristaltic device 51, a drive module 52, and a clamping mechanism 53. The peristaltic device 51 is used to squeeze or release the conduit 23 to control the liquid flow; the clamping mechanism 53 is connected to the output end of the drive module 52, and the clamping mechanism 53 is used to perform linear motion under the drive of the drive module 52 to press the conduit 23 onto the peristaltic device 51 or release the conduit 23 from the peristaltic device 51. The drive module 52 is used to drive the clamping mechanism 53 to press the conduit 23 to cooperate with the peristaltic device 51 in actively pumping the liquid in the conduit 23; and to drive the clamping mechanism 53 to release the conduit 23 so that the liquid in the conduit 23 forms a siphon flow under the action of an external liquid level difference.

[0083] Specifically, the peristaltic device 51 is used to periodically squeeze or release the catheter 23 mechanically. When squeezing occurs, the inner cavity of the catheter 23 is temporarily sealed, pushing the liquid in front of it forward; when releasing, the catheter 23 returns to its original shape, allowing the liquid to fill. By controlling the rhythm and direction of squeezing, the direction and speed of liquid flow can be actively controlled. The clamping mechanism 53 is directly connected to the output end of the drive module 52. Driven by the drive module 52, the clamping mechanism 53 can perform precise linear motion. Through its linear motion, the clamping mechanism 53 presses the catheter 23 against the peristaltic device 51 or releases the catheter 23 from the peristaltic device 51. When pressed, the catheter 23 is stably fixed in the working position of the peristaltic device 51; when released, the catheter 23 is released from the forced contact with the peristaltic device 51 and is in a free or relaxed state. When it is necessary to start the device for plasma transfer, the drive module 52 drives the clamping mechanism 53 to move, pressing the catheter 23 against the peristaltic device 51. Subsequently, the peristaltic device 51 actively pumps the thawed plasma from the frozen plasma bag 21 to the transfer bag 22 through regular squeezing actions, providing initial power and ensuring the reliability of the transfer initiation. After the active pumping establishes the initial flow or a certain liquid level difference, in order to carry out subsequent transfers more gently and energy-efficiently, the drive module 52 drives the clamping mechanism 53 to move in the opposite direction, thereby releasing the conduit 23 so that it is no longer forcibly squeezed by the peristaltic device 51. Since the height of the frozen plasma bag 21 is set higher than that of the transfer bag 22, there is a stable external liquid level difference between the two. After the conduit 23 is released, under the action of this liquid level difference, the liquid in the conduit 23 can form a continuous siphon flow, automatically flowing from the higher bag to the lower bag. This setting integrates the active drive function of the peristaltic module 50 with the siphon process, effectively improving the automation level of the equipment and the user experience, and enabling precise and automated control of the fluid transfer stage throughout the preparation process.

[0084] In some embodiments, the clamping mechanism 53 includes a first push rod 531, a second push rod 532, and a push plate 533. One end of the first push rod 531 is connected to the output end of the electric cylinder; the push plate 533 is connected to the second push rod 532 and is used to directly contact and press the conduit 23; wherein, the first push rod 531 and the second push rod 532 are connected by a floating connection structure, so that the push plate 533 can adaptively press the conduit 23.

[0085] Specifically, one end of the first push rod 531 is fixedly connected to the output end of the electric cylinder, thereby directly transmitting the linear driving force generated by the electric cylinder to the clamping mechanism 53. The second push rod 532 is configured as an intermediate force transmission component connected to the actuator. The push plate 533 is connected to the second push rod 532 and moves linearly under the drive of the second push rod 532, thereby achieving direct contact and clamping of the guide tube 23. The first push rod 531 and the second push rod 532 are not rigidly fixed, but are connected by a floating connection structure, so that the first push rod 531 and the second push rod 532 maintain linkage along the electric cylinder driving direction, while having a certain degree of relative motion freedom or angle adjustment range in a plane perpendicular to this direction. When the electric cylinder transmits driving force through the first push rod 531, thereby pushing the second push rod 532 and the push plate 533 to move towards the guide tube 23, the floating connection structure allows the push plate 533 to make slight adaptive adjustments according to the actual position and contour of the surface of the guide tube 23 at the moment of contact.

[0086] In some embodiments, the peristaltic device 51 includes a drive motor 511, a peristaltic slider 512, and a pump frame 514. The peristaltic slider 512 is connected to the drive motor 511 via a transmission mechanism 513 and performs reciprocating or rotational motion under the drive of the drive motor 511 to periodically squeeze the conduit 23; the pump frame 514 is used to support the drive motor 511 and the peristaltic slider 512; wherein, the push plate 533 of the clamping mechanism 53 is configured to press the conduit 23 against the working surface of the peristaltic slider 512.

[0087] Specifically, the drive motor 511 is the power source for the peristaltic device 51, providing rotational motion output. The peristaltic slider 512 is connected to the drive motor 511 via a transmission mechanism 513. Driven by the drive motor 511, the transmission mechanism 513 converts the motor's rotational motion into specific reciprocating linear motion or rotational motion of the peristaltic slider 512. Regardless of whether the peristaltic slider 512 performs reciprocating or rotational motion, its design purpose is to enable its working surface to periodically contact and flatten the passing conduit 23 segment, thereby forming a forward-propelling liquid column within the conduit 23 to achieve the pumping function; when the slider's working surface leaves, the conduit 23 rebounds, creating a negative pressure inside to draw in subsequent liquid, thus repeating the cycle. The pump body frame 514 is a rigid structural component, used to provide a stable mounting reference and support for the drive motor 511, transmission mechanism 513, and peristaltic slider 512, ensuring that each component maintains the correct relative position and that power transmission is precise and reliable. The push plate 533 is positioned opposite the working surface of the peristaltic slider 512, and the conduit 23 is placed between the working surface of the peristaltic slider 512 and the push plate 533 of the clamping mechanism 53. When active pumping is required, the push plate 533 of the clamping mechanism 53 moves under the drive of the electric cylinder, pressing the conduit 23 against the working surface of the peristaltic slider 512, so that the conduit 23 is pre-positioned and pressed against the effective working area of ​​the slider. Subsequently, the drive motor 511 is started, driving the peristaltic slider 512 to move, performing efficient and regular compression on the conduit 23 that has been pressed in this position, realizing controllable liquid pumping. When it is necessary to switch to siphon mode, the electric cylinder drives the push plate 533 to move in the opposite direction, releasing the conduit 23, causing it to break away from the forced contact with the working surface of the peristaltic slider 512, creating conditions for the conduit 23 to deform freely under the action of liquid level difference and form a siphon.

[0088] In some embodiments, the transmission mechanism 513 is a synchronous belt transmission mechanism 513; the output shaft of the drive motor 511 is provided with a driving belt pulley 515, the peristaltic slider 512 and the driven pulley 516 are coaxially arranged, and the synchronous belt is tensioned between the driving belt pulley 515 and the driven pulley 516; wherein, in the pressing state, the push plate 533 presses the guide tube 23 against the peristaltic slider 512.

[0089] The foregoing description and accompanying drawings fully illustrate embodiments of the present disclosure to enable those skilled in the art to practice them. Other embodiments may include structural and other changes. The embodiments represent only possible variations. Individual components and functions are optional unless explicitly required, and the order of operation may vary. Parts and features of some embodiments may be included or substituted for parts and features of other embodiments. Embodiments of the present disclosure are not limited to the structures described above and shown in the accompanying drawings, and various modifications and changes may be made without departing from its scope. The scope of the present disclosure is limited only by the appended claims.

Claims

1. A cold precipitation preparation apparatus, characterized in that, include: The preparation module (30) is used to accommodate the frozen plasma bag (21) and the transfer bag (22) respectively, and the transfer bag (22) and the frozen plasma bag (21) are connected by a conduit (23); A water supply system (40) is connected to the preparation module (30); A peristaltic module (50) is provided corresponding to the conduit (23), and the conduit (23) is at least partially fixed to the peristaltic module (50); and, The control system is electrically connected to the preparation module (30), the water supply system (40), and the peristaltic module (50), respectively. The control system is used to control the water supply system (40) to provide water at a preset temperature to the preparation module (30) so that the plasma in the frozen plasma bag (21) melts; Under the condition that the drainage preset conditions are met, the peristaltic module (50) is controlled to act on the catheter (23) so that the plasma in the frozen plasma bag (21) is transferred to the transfer bag (22) through the catheter (23).

2. The cold precipitation preparation apparatus according to claim 1, characterized in that, The preparation module (30) includes: Water tank (31) is connected to the water supply system (40); A melting frame (32) for receiving the frozen plasma bag (21), the melting frame (32) being positioned above the water tank (31); and, A transfer box (33) is used to contain the transfer bag (22); The melting frame (32) is at least partially located within the water tank (31); The control system is used to control the water supply system (40) to provide water at a preset temperature to the preparation module (30), including: the control system is used to control the water supply system (40) to deliver water at a preset temperature to the water tank (31).

3. The cold precipitation preparation apparatus according to claim 2, characterized in that, The water supply system (40) includes: A cooling water tank (411) is connected to the inlet of the water tank (31), and the cooling water tank (411) is used to supply water at a preset temperature to the water tank (31); and, A collection tank (412) is connected to the outlet of the water tank (31) and is used to receive the water discharged from the water tank (31).

4. The cold precipitation preparation apparatus according to claim 3, characterized in that, The water tank (31) includes a first water outlet and a second water outlet, and the position of the first water outlet is lower than the position of the second water outlet; The water supply system (40) also includes: Water outlet pipe (422) is used to connect the first water outlet and the water collection tank (412); and, An overflow pipe (423) is used to connect the second outlet and the collection tank (412).

5. The cold precipitation preparation apparatus according to claim 4, characterized in that, The water supply system (40) also includes: A water inlet solenoid valve (431) is installed at the water inlet of the water tank (31); and, A water outlet solenoid valve (432) is installed at the first water outlet of the water tank (31); The control system is electrically connected to the inlet solenoid valve (431) and the outlet solenoid valve (432) respectively to control the opening and closing of the inlet solenoid valve (431) and the outlet solenoid valve (432).

6. The cold precipitation preparation apparatus according to claim 5, characterized in that, The control system is used to control the water supply system (40) to deliver water at a preset temperature to the water tank (31) by controlling the inlet solenoid valve (431) and the outlet solenoid valve (432) to open. The opening degree of the outlet solenoid valve (432) is less than or equal to the opening degree of the inlet solenoid valve (431).

7. The cold precipitation preparation apparatus according to claim 3, characterized in that, The cold precipitation preparation instrument includes multiple preparation modules (30) and multiple peristaltic modules (50); Among them, multiple peristaltic modules (50) and multiple preparation modules (30) are set up one-to-one.

8. The cold precipitation preparation apparatus according to claim 7, characterized in that, The water supply system (40) also includes: The equalizing water tank (413) includes an inlet end and multiple outlet ends. The inlet end is connected to the cooling water tank (411), and the multiple outlet ends are respectively connected to the water tanks (31) of the multiple preparation modules (30).

9. The cold precipitation preparation apparatus according to claim 1, characterized in that, The preset conditions for diversion include: The water supply system (40) provides water at a preset temperature to the preparation module (30) for a time that is greater than or equal to a preset time.

10. The cold precipitation preparation apparatus according to claim 1, characterized in that, Also includes: Weighing component (60) for obtaining the weights of the frozen plasma bag (21) and the transfer bag (22) respectively; The control system is also electrically connected to the weighing component (60) to control the cryoprecipitate preparation instrument to run a preset preparation program based on the weight of the frozen plasma bag (21) and the transfer bag (22).

11. The cold precipitation preparation apparatus according to claim 10, characterized in that, The preset preparation procedure includes: Based on the weight of the frozen plasma bag (21), the preparation module (30) is controlled to transfer a preset weight of plasma; The weight of the transferred plasma is directly proportional to the weight of the frozen plasma bag (21).

12. The cold precipitation preparation apparatus according to claim 11, characterized in that, When the weight of the transferred plasma reaches a preset weight, the peristaltic module (50) is controlled to block the catheter (23).

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