A bismuth-copper bimetallic coordination nanomaterial, its preparation method and application

By combining bismuth-copper bimetallic nanomaterials with sonodynamic therapy and chemodynamic therapy, the problem of low efficiency of sonodynamic therapy in the tumor microenvironment has been solved, achieving the effect of efficiently killing tumor cells and activating the immune response.

CN122075686APending Publication Date: 2026-05-26HUNAN SHIZHUYUAN NON FERROUS METAL +1
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUNAN SHIZHUYUAN NON FERROUS METAL
Filing Date
2026-01-07
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing sonodynamic therapy (SDT) is limited by the dual barriers of the tumor microenvironment in tumor treatment, resulting in low treatment efficiency and an inability to effectively kill cancer cells and activate the immune system.

Method used

A bismuth-copper bimetallic coordination nanomaterial was developed. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), Cu2+ catalyzes a Fenton-like reaction in tumor endogenous H2O2 to generate highly toxic hydroxyl radicals, which are internalized into tumor cells via copper transporter protein (CTR1), inducing oligomerization of the mitochondrial enzyme DLAT and activating immunogenic cell death.

Benefits of technology

It achieves efficient generation of reactive oxygen species (ROS) under ultrasound stimulation, enhances the oxidative stress response of tumor cells, depletes the tumor's antioxidant barrier, directly kills tumor cells and activates the immune system, and effectively inhibits the proliferation of cancer cells.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122075686A_ABST
    Figure CN122075686A_ABST
Patent Text Reader

Abstract

This invention discloses a bismuth-copper bimetallic coordination nanomaterial, its preparation method, and its applications, belonging to the technical field of biofunctional materials. The prepared bismuth-copper bimetallic coordination nanomaterial can efficiently generate reactive oxygen species (ROS) under ultrasonic stimulation, initiating the sonodynamic therapy (SDT) process; the Cu in this material... 2+ The weakly acidic environment of the tumor microenvironment can also trigger a Fenton-like reaction, generating cytotoxic hydroxyl radicals (•OH) and oxygen in situ, thus initiating the chemokinetic therapy (CDT) process. Through the synergistic effect of sonodynamic therapy (SDT) and chemokinetic therapy (CDT), they jointly inhibit cancer cell proliferation and promote T cell generation.
Need to check novelty before this filing date? Find Prior Art