Portable negative pressure drug delivery device and method for high-altitude medical treatment

Abstract

This application provides a portable negative pressure dosing device and method for high-altitude medical treatment. The method determines the negative pressure threshold range of the main drug solution bag by using a high-altitude low-pressure compensation coefficient and a target volume. When the pressure characteristic value inside the main drug solution bag exceeds the upper limit of the negative pressure threshold range, the resistance adjustment value of the operating lever at the current operation stage is determined based on the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold. The movement resistance of the manual operating lever is adjusted based on this resistance adjustment value, thereby obtaining the tactile feedback characteristics of the manual operating lever for the operator. During the dosing process of the main drug solution bag, the actual pressure of the drug solution bag is compensated through the tactile feedback characteristics to maintain the current pressure value inside the main drug solution bag within the negative pressure threshold range. Based on the above scheme, stable negative pressure control of the negative pressure dosing device in high-altitude environments can be achieved.

Description

Technical Field

[0001] This application relates to the field of portable medical device technology, and more specifically, to a portable negative pressure drug delivery device and method for high-altitude medical use. Background Technology

[0002] The high-altitude medical device is a portable medical equipment designed for low-pressure environments at high altitudes. It features lightweight, robust sealing, and environmental adaptability. Without stable power support, the device can quickly establish a controllable negative pressure environment through simple mechanical means for drug preparation, wound drainage, and isolation procedures, ensuring the feasibility and safety of basic medical treatment under extreme altitude and battlefield conditions.

[0003] Existing control logic lacks a closed-loop response to environmental pressure variables. Atmospheric pressure in high-altitude areas decreases exponentially with increasing altitude, directly altering the absolute pressure difference balance between the inside and outside of the sealed medication bag. Using a fixed negative pressure parameter essentially pre-sets a target absolute pressure value. When the ambient pressure decreases, the suction work required to reach this absolute pressure remains the same, but the maximum theoretical pressure difference the system can achieve decreases, leading to a weakened actual negative pressure build-up capability, manifesting as insufficient negative pressure. Conversely, if an excessively high suction volume is preset to adapt to high altitudes, the system will overcompensate in low-pressure environments, resulting in excessively low absolute pressure inside the bag. This not only causes turbulence and bubble formation in the medication but may also exceed the safe pressure tolerance of flexible containers, compromising the stability and consistency of operations across altitudes. Therefore, achieving stable negative pressure control of negative pressure dosing devices in high-altitude environments, thereby improving the reliability of medical medication dosing processes, has become a challenge for the industry. Summary of the Invention

[0004] This application provides a portable negative pressure dosing device and method for high-altitude medical treatment, which can achieve stable negative pressure control of the negative pressure dosing device in high-altitude environments, thereby improving the reliability of the high-altitude medical dosing process.

[0005] Firstly, this application provides a portable negative pressure drug delivery method for high-altitude medical use, comprising: When the operator repeatedly moves the manual control lever to establish the expected negative pressure, the pressure change information inside the main drug bag is collected, and then the pressure characteristic value inside the main drug bag is extracted from the pressure change information. The high-altitude low-pressure compensation coefficient in the main drug solution bag is determined based on the altitude and absolute atmospheric pressure of the device environment. The negative pressure threshold range of the main drug solution bag under negative pressure is determined by the high-altitude low-pressure compensation coefficient and the target volume of the main drug solution bag. When the pressure characteristic value is greater than the upper limit of the negative pressure threshold in the negative pressure threshold range, the resistance adjustment value of the operating lever in the current operation stage is determined according to the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold. Based on the resistance adjustment value, the motion resistance of the manual operating lever is adjusted to obtain the tactile feedback characteristics of the manual operating lever to the operator. During the dosing process of the main drug solution bag, the actual pressure of the drug solution bag is compensated by the tactile feedback feature to maintain the current pressure value inside the main drug solution bag within the negative pressure threshold range.

[0006] In some embodiments, extracting the pressure characteristic value inside the main drug bag from the pressure change information specifically includes: The pressure change information is filtered by a moving average to obtain a filtered pressure sequence. Based on the filtered pressure sequence, the pressure change within each sampling period is calculated. The pressure characteristic value inside the main drug solution bag is determined based on all pressure changes.

[0007] In some embodiments, determining the high-altitude low-pressure compensation coefficient in the main drug solution bag based on the altitude and absolute atmospheric pressure of the device environment specifically includes: The device obtains the real-time absolute air pressure by integrating a barometric pressure sensor and obtains the current altitude value by manual input, thereby obtaining the relative air pressure ratio of the device environment; The real-time temperature of the environment in which the device is located is obtained using a temperature sensor, and a temperature correction coefficient is obtained based on the atmospheric temperature-altitude model of the plateau region. The high-altitude low-pressure compensation coefficient inside the medicine bag is determined based on the relative air pressure ratio and the temperature correction coefficient.

[0008] In some embodiments, determining the negative pressure threshold range of the main drug solution bag during negative pressure establishment using the high-altitude low-pressure compensation coefficient and the target volume of the main drug solution bag specifically includes: Based on the target volume of the main drug solution bag, the basic negative pressure range under standard conditions is obtained from a preset lookup table; The base pressure range is linearly scaled using the plateau low-pressure compensation coefficient to obtain the target negative pressure range under plateau conditions. Based on the dynamic tolerance band of the main drug solution bag, the tolerance of the target negative pressure range is expanded to obtain the negative pressure threshold range established by the main drug solution bag under negative pressure.

[0009] In some embodiments, determining the resistance adjustment value of the operating lever in the current operating phase based on the difference between the pressure characteristic value and the upper limit of the negative pressure threshold specifically includes: Determine the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold, and obtain the historical correction factor of the resistance adjustment effect feedback in the previous operation cycle; Based on the current operating stage of the control lever and the difference amplitude, the corresponding basic resistance adjustment value is determined through a preset fuzzy control lookup table; The resistance adjustment value of the operating lever in the current operating phase is determined by the historical correction factor and the resistance adjustment base value.

[0010] In some embodiments, the motion resistance of the manual operating lever is adjusted based on the resistance adjustment value to obtain the tactile feedback characteristics of the manual operating lever to the operator, specifically including: The resistance adjustment value is converted into a control signal, which drives the magnetorheological damper integrated at the operating lever shaft to change the current intensity of the internal magnetic field, thereby adjusting the damping force of the operating lever movement. By controlling the damping force to undergo step changes and pulse fluctuations within a specified time period, the tactile feedback characteristics of the manual control lever to the operator can be obtained.

[0011] In some embodiments, the tactile feedback feature is used to compensate for the actual pressure of the medicine bag and maintain the current pressure value inside the main medicine bag within the negative pressure threshold range. This specifically includes: After the operator perceives the tactile feedback features, they determine the current system status according to the pre-trained operating procedures and perform corresponding compensatory manual operations. When the operator adjusts the manual operation, the negative pressure convergence characteristics of the current pressure value inside the main drug bag relative to the negative pressure threshold range are determined by the pressure change information collected in real time. The actual pressure of the medicine bag is compensated based on the negative pressure convergence characteristic to maintain the current pressure value inside the main medicine bag within the negative pressure threshold range.

[0012] Secondly, this application provides a portable negative pressure drug delivery device for high-altitude medical use, comprising: The acquisition module is used to collect pressure change information inside the main drug bag when the operator repeatedly pulls the manual control lever to establish the expected negative pressure, and then extract the pressure characteristic value inside the main drug bag from the pressure change information. The processing module is used to determine the high-altitude low-pressure compensation coefficient in the main medicine bag based on the altitude and absolute atmospheric pressure of the device environment, and to determine the negative pressure threshold range of the main medicine bag under negative pressure by using the high-altitude low-pressure compensation coefficient and the target volume of the main medicine bag. The processing module is further configured to determine the resistance adjustment value of the operating lever in the current operation stage based on the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold range when the pressure characteristic value is greater than the upper limit of the negative pressure threshold range, and to adjust the motion resistance of the manual operating lever based on the resistance adjustment value, thereby obtaining the tactile feedback characteristics of the manual operating lever to the operator. The execution module is used to provide feedback compensation for the actual pressure of the main drug solution bag during the drug addition process through the tactile feedback feature, so as to maintain the current pressure value inside the main drug solution bag within the negative pressure threshold range.

[0013] Thirdly, this application provides a computer device, the computer device including a memory and a processor, the memory for storing a computer program, and the processor for calling and running the computer program from the memory, so that the computer device performs the above-described portable negative pressure drug delivery method for high-altitude medical use.

[0014] Fourthly, this application provides a computer-readable storage medium storing instructions or code that, when executed on a computer, cause the computer to implement the aforementioned portable negative pressure drug delivery method for high-altitude medical use.

[0015] The technical solutions provided by the embodiments disclosed in this application have the following beneficial effects: This application provides a portable negative pressure medication dispensing device and method for high-altitude medical use. When the operator repeatedly operates a manual lever to establish the desired negative pressure, pressure change information inside the main medication bag is collected, and pressure characteristic values ​​inside the main medication bag are extracted from the pressure change information. A high-altitude low-pressure compensation coefficient is determined based on the altitude and absolute atmospheric pressure of the device environment. The negative pressure threshold range for establishing negative pressure in the main medication bag is determined using the high-altitude low-pressure compensation coefficient and the target volume of the main medication bag. When the pressure characteristic value is greater than the upper limit of the negative pressure threshold range, the resistance adjustment value of the lever at the current operating stage is determined based on the difference between the pressure characteristic value and the upper limit of the negative pressure threshold. The movement resistance of the manual lever is adjusted based on the resistance adjustment value, thereby obtaining the tactile feedback characteristics of the manual lever to the operator. During the medication dispensing process in the main medication bag, the actual pressure of the medication bag is compensated through the tactile feedback characteristics to maintain the current pressure value inside the main medication bag within the negative pressure threshold range.

[0016] Therefore, in this application, during the dosing process of the main drug bag, the tactile feedback feature is used to compensate for the actual pressure of the drug bag, maintaining the current pressure value inside the main drug bag within the negative pressure threshold range. First, determining the negative pressure threshold range completes the accurate quantitative modeling of the high-altitude, low-pressure physical environment and transforms its influence into a calculable correction factor. This compensation coefficient is applied to the basic negative pressure range of the target volume of the main drug bag and subjected to environmentally adaptive linear scaling, enabling the setting reference of the entire control system to migrate synchronously with the external environment. This ensures that, whether in plains or plateaus, an optimal negative pressure operating point adapted to the current atmospheric conditions can be automatically found, eliminating the systematic errors introduced by environmental variables and providing a stable and correct reference system for control and feedback actions, significantly improving the environmental versatility of the device and the accuracy of the control reference. Then, the tactile feedback feature is determined to classify different pressure anomaly patterns into different intensities. The resistance command of the mode is converted into a perceptible change in damping force on the operating lever in real time through actuators such as magnetorheological dampers. This creates a direct state communication channel that does not rely on vision or complex instruments. The internal pressure state information is encoded into physical signals that can be directly perceived by the operator's limbs. After the operator perceives an abnormal tactile sensation, they perform corresponding compensatory operations according to training. The effect is immediately monitored by the pressure sensor, forming a closed loop. In essence, the operator is integrated into an intelligent execution and correction node in the control loop, enhancing the ability to suppress random interference during operation. Through mandatory and intuitive human-machine interaction, the main risks caused by the uncertainty of human operation can be effectively overcome under power-constrained high-altitude conditions. This significantly improves the reliability and overall robustness of maintaining pressure stability in complex field environments. In summary, based on the above scheme, negative pressure stability control of negative pressure dosing devices in high-altitude environments can be achieved, thereby improving the reliability of high-altitude medical dosing processes. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is an exemplary flowchart of a portable negative pressure drug delivery method for high-altitude medical use, as shown in some embodiments of this application. Figure 2 This is a flowchart illustrating the process of determining the resistance adjustment value according to some embodiments of this application; Figure 3This is a schematic diagram of the structure of a portable negative pressure drug delivery device for high-altitude medical use, as shown in some embodiments of this application; Figure 4 This is a schematic diagram of the structure of a computer device for implementing a portable negative pressure drug delivery method for high-altitude medical use, according to some embodiments of this application. Detailed Implementation

[0019] To better understand the technical solution of this application, the technical solution of this application will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0020] refer to Figure 1 The figure is an exemplary flowchart of a portable negative pressure drug delivery method for high-altitude medical use, according to some embodiments of this application. This portable negative pressure drug delivery method for high-altitude medical use mainly includes the following steps: In step 101, when the operator repeatedly moves the manual control lever to establish the expected negative pressure, pressure change information inside the main drug bag is collected, and then the pressure characteristic value inside the main drug bag is extracted from the pressure change information.

[0021] It should be noted that, in this application, the pressure change information is a data set used to reflect the continuous state of the instantaneous pressure change over time in the gas space inside the main drug solution bag during the establishment of negative pressure; the manual operating lever is a transmission component used to convert the manual torque applied by the operator into reciprocating linear motion, thereby driving the manual negative pressure generating device to do work; the expected negative pressure is a pressure range below the ambient atmospheric pressure that is expected to be reached and maintained inside the main drug solution bag, and this pressure range is pre-calculated and set by the control module based on environmental parameters; the main drug solution bag is a flexible or semi-rigid sterile sealed container used to establish negative pressure before drug addition, to hold the drug solution mixture during drug addition, and to be directly used for infusion after drug addition.

[0022] In practice, the operator repeatedly pulls the manual control lever, driving the piston of the mechanically connected manual negative pressure generating device (e.g., a piston pump) to reciprocate. The pump's suction end is connected to the exhaust port of the main medicine bag through a vent pipe, thereby generating negative pressure in the sealed cavity of the main medicine bag. During the reciprocating movement of the control lever, pressure sensing elements installed on the inner wall of the main medicine bag or on the vent pipe continuously collect the instantaneous pressure value of the gas space inside the main medicine bag at a frequency of ten times per second, generating a set of discrete pressure readings arranged in chronological order. The collection of all discrete pressure readings is used as pressure change information.

[0023] In some embodiments, extracting the pressure characteristic value within the main drug solution bag from the pressure change information can be achieved using the following steps: The pressure change information is filtered by a moving average to obtain a filtered pressure sequence. Based on the filtered pressure sequence, the pressure change within each sampling period is calculated. The pressure characteristic value inside the main drug solution bag is determined based on all pressure changes.

[0024] It should be noted that in this application, the filtered pressure sequence is a time series data set that reflects the smooth change trend of the internal pressure of the main drug solution bag; the pressure change is an algebraic value used to quantify the amplitude and direction of the pressure change inside the main drug solution bag between two adjacent sampling times; and the pressure characteristic value is a statistical value that characterizes the core attribute of the pressure change inside the main drug solution bag under the current operating stage.

[0025] In specific implementation, firstly, the pressure change information is filtered using a moving average to obtain the filtered pressure sequence. This can be achieved as follows: the control module preprocesses the raw pressure data in the pressure change information. Specifically, a moving window averaging algorithm can be used for digital filtering. A fixed-length data window is set, for example, containing the ten most recent consecutive instantaneous pressure readings. Each time a new instantaneous pressure reading is obtained, the window slides forward once, and the arithmetic mean of all readings within the window is output. This effectively smooths out sudden changes in readings or high-frequency noise caused by mechanical vibration or electromagnetic interference. The set of arithmetic means arranged in chronological order is used as the filtered pressure sequence. Then, based on the filtered pressure sequence, the pressure change within each sampling period is calculated as follows: based on the filtered pressure sequence, the difference between two adjacent effective pressure readings is calculated. Specifically, the instantaneous pressure value at each sampling moment in the pressure sequence is subtracted from the pressure change value. The instantaneous pressure value at the previous sampling moment yields the pressure change within that sampling period. This pressure change is algebraic, with positive and negative values ​​representing pressure increases and decreases, respectively. The absolute value reflects the severity of the pressure change. This method yields a time-ordered sequence of pressure changes corresponding to the filtered pressure sequence. Finally, the pressure characteristic value within the main drug bag can be determined based on all pressure changes using the following method: Extract and determine the value that characterizes the current negative pressure establishment state from all pressure changes. For example, during the initial rapid evacuation phase, the maximum value of all pressure changes within a certain time period (defaulting to the last two seconds) can be used as the pressure characteristic value to assess the pressure establishment rate. During the stabilization phase approaching the target negative pressure, the standard deviation of all pressure changes within the same time period can be used as the pressure characteristic value to assess pressure stability. This scalar value is then used as the pressure characteristic value within the main drug bag.

[0026] In step 102, the high-altitude low-pressure compensation coefficient in the main medicine bag is determined based on the altitude and absolute atmospheric pressure of the device environment. The negative pressure threshold range of the main medicine bag under negative pressure is determined by the high-altitude low-pressure compensation coefficient and the target volume of the main medicine bag.

[0027] In some embodiments, determining the high-altitude low-pressure compensation coefficient in the main drug solution bag based on the altitude and absolute atmospheric pressure of the device environment can be achieved through the following steps: The device obtains the real-time absolute air pressure by integrating a barometric pressure sensor and obtains the current altitude value by manual input, thereby obtaining the relative air pressure ratio of the device environment; The real-time temperature of the environment in which the device is located is obtained using a temperature sensor, and a temperature correction coefficient is obtained based on the atmospheric temperature-altitude model of the plateau region. The high-altitude low-pressure compensation coefficient inside the medicine bag is determined based on the relative air pressure ratio and the temperature correction coefficient.

[0028] It should be noted that, in this application, the relative pressure ratio is a dimensionless ratio parameter characterizing the degree of attenuation of the absolute atmospheric pressure at the current operating location relative to the standard atmospheric pressure at sea level; the temperature correction coefficient is a correction factor used to quantify the difference between the actual ambient temperature and the theoretical standard temperature at the current altitude, which affects the pressure sensing and aerodynamic effects; the plateau low-pressure compensation coefficient is an environmental coefficient used to compensate for the effects of low air pressure and temperature changes caused by high altitude, and to uniformly adjust all air pressure-related control parameters in the portable negative pressure dosing system.

[0029] In practice, firstly, the real-time absolute atmospheric pressure is acquired through an integrated pressure sensor, and the current altitude is obtained manually. The relative pressure ratio of the device's environment can then be calculated as follows: the device measures the absolute atmospheric pressure of the external environment using its integrated pressure sensor; simultaneously, the operator manually inputs the altitude of the work site via the device's input interface, which can be obtained from a map, altimeter, or empirical data. The control module divides the real-time absolute atmospheric pressure by a pre-stored standard sea-level reference atmospheric pressure (e.g., 101.325 kPa) to calculate the relative pressure ratio of the device's environment as a decimal, representing the percentage of the current ambient pressure relative to the standard sea-level atmospheric pressure. Then, a temperature sensor acquires the real-time temperature of the environment around the device, and based on the atmospheric temperature-altitude model for high-altitude regions, the relative pressure ratio is calculated. The temperature correction coefficient can be implemented as follows: the device uses a built-in temperature sensor to sense and acquire the real-time temperature of the surrounding air. The control module, based on a pre-existing mathematical relationship describing the variation of air temperature with altitude in plateau regions (e.g., a simplified version of the International Standard Atmospheric Model), substitutes the manually input altitude value into this relationship to calculate the theoretical standard temperature corresponding to that altitude. The real-time temperature is compared with the theoretical standard temperature, and the temperature correction coefficient is mapped and filtered through a preset nonlinear conversion relationship. This temperature correction coefficient can quantify the impact of the actual ambient temperature deviating from the theoretical standard temperature on the physical effects of air pressure. Finally, the plateau low-pressure compensation coefficient inside the medicine bag can be determined based on the relative air pressure ratio and the temperature correction coefficient, which can be implemented as follows: the product of the relative air pressure ratio and the temperature correction coefficient is used as the plateau low-pressure compensation coefficient inside the medicine bag.

[0030] In some embodiments, determining the negative pressure threshold range of the main drug solution bag during negative pressure establishment using the high-altitude low-pressure compensation coefficient and the target volume of the main drug solution bag can be achieved through the following steps: Based on the target volume of the main drug solution bag, the basic negative pressure range under standard conditions is obtained from a preset lookup table; The base pressure range is linearly scaled using the plateau low-pressure compensation coefficient to obtain the target negative pressure range under plateau conditions. Based on the dynamic tolerance band of the main drug solution bag, the tolerance of the target negative pressure range is expanded to obtain the negative pressure threshold range established by the main drug solution bag under negative pressure.

[0031] It should be noted that in this application, the basic negative pressure range is a reference pressure range used to provide a negative pressure setting range for the current main drug solution bag under standard atmospheric conditions and normal temperature; the target negative pressure range is a preliminary target pressure range used to guide the establishment of negative pressure in high-altitude environments; and the negative pressure threshold range is an acceptable pressure working range used as a control logic judgment and execution benchmark in the actual negative pressure establishment and control process.

[0032] In specific implementation, firstly, based on the target volume of the main medication bag, the basic negative pressure range under standard conditions can be obtained from a preset lookup table in the following way: the control module retrieves the recommended basic negative pressure range for negative pressure medication operation under standard conditions (defined as sea level, standard atmospheric pressure, and room temperature) from a lookup table pre-stored in the device, based on the preset target volume of the main medication bag (e.g., 500 ml). This lookup table uses the medication bag volume as an index and pre-associates experimentally verified ideal lower and upper negative pressure values ​​that ensure stable medication inhalation without excessive foaming. These two values ​​together constitute the basic negative pressure range. Then, the basic pressure range is linearly scaled using the high-altitude low-pressure compensation coefficient to obtain the target negative pressure range under high-altitude conditions. This can be achieved in the following way: the control module applies the high-altitude low-pressure compensation coefficient to the basic negative pressure range. Specifically, the lower and upper limits of the basic negative pressure range are multiplied by the same high-altitude low-pressure compensation coefficient, which is usually less than 1, thereby making the range within the range... All pressure values ​​are reduced proportionally (i.e., the absolute value of negative pressure decreases). The linear scaling process adjusts the pressure range originally applicable to the standard environment to a pressure level that matches the current low-pressure environment of the plateau, thus obtaining the target negative pressure range under the current plateau environment. Finally, based on the dynamic tolerance band of the main drug bag, the target negative pressure range is expanded to obtain the negative pressure threshold range established by the main drug bag under negative pressure. This can be achieved in the following way: In order to enhance the robustness and fault tolerance of the dynamic operation process, the target negative pressure range needs to be appropriately expanded. The control module dynamically presets the size of a dynamic tolerance band based on the stability of the pressure change in the main drug bag monitored in real time (e.g., the standard deviation of the pressure change rate). This dynamic tolerance band will shrink when the pressure fluctuation is small and will be appropriately widened when the pressure fluctuation is large. Subtract this dynamic tolerance band from the lower limit of the target negative pressure range and add this dynamic tolerance band to the upper limit to obtain a wider working range. This working range can be used as the negative pressure threshold range established by the main drug bag under negative pressure for actual judgment of whether the negative pressure meets the standard and to guide subsequent feedback control.

[0033] In step 103, when the pressure characteristic value is greater than the upper limit of the negative pressure threshold in the negative pressure threshold range, the resistance adjustment value of the operating lever in the current operation stage is determined according to the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold. Based on the resistance adjustment value, the motion resistance of the manual operating lever is adjusted to obtain the tactile feedback characteristics of the manual operating lever to the operator.

[0034] It should be noted that in this application, when the pressure characteristic value is greater than the upper limit of the negative pressure threshold in the negative pressure threshold range, the control module determines that there is an abnormality in the current pressure building process, such as: the operation speed is too fast or there is a potential leak in the system. It must issue an immediate warning to the operator through tactile feedback. The core of this logic is to convert the dynamic pressure change that exceeds the allowable upper limit (i.e., the excessively high pressure change rate or fluctuation) into a resistance change pattern that the operator can directly perceive (e.g., a significant "jerk" feeling), thereby forcing the operator to pause or adjust the current operation to prevent the failure of negative pressure building, seal failure or pre-filling vaporization of the liquid due to continuous abnormal operation, and to ensure the reliability and controllability of the negative pressure building process in the high-altitude low-pressure environment.

[0035] In some embodiments, the resistance adjustment value of the operating lever in the current operating phase is determined based on the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold, with reference to... Figure 2 The diagram is a flowchart illustrating the determination of the resistance adjustment value in some embodiments of this application. In this embodiment, the determination of the resistance adjustment value can be achieved using the following steps: In step 1031, the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold is determined, and the historical correction factor of the resistance adjustment effect feedback in the previous operation cycle is obtained; In step 1032, the corresponding resistance adjustment base value is determined by using a preset fuzzy control lookup table based on the current operating stage of the control lever and the difference amplitude. In step 1033, the resistance adjustment value of the operating lever in the current operating phase is determined by the historical correction factor and the resistance adjustment base value.

[0036] It should be noted that, in this application, the difference amplitude is a relative deviation value used to quantify the degree of deviation between the current actual pressure dynamic and the theoretical allowable upper limit; the historical correction factor is a correction item used to dynamically fine-tune and compensate for the current resistance adjustment value; the resistance adjustment base value is the initial resistance control quantity without historical feedback correction; and the resistance adjustment value is a control command used to change the magnitude of the resistance of the manual operating lever.

[0037] In specific implementation, firstly, determining the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold, and obtaining the historical correction factor of the resistance adjustment effect feedback in the previous operating cycle can be achieved in the following way: The pressure characteristic value (e.g., the maximum pressure change rate during the rapid pressure build-up period) is algebraically compared with the control threshold (i.e., the upper limit of the allowable maximum pressure change rate) corresponding to the upper limit of the negative pressure threshold obtained from the negative pressure threshold range. The difference between the two is calculated, and the result of dividing this difference by the control threshold is taken as a dimensionless difference amplitude representing the degree of deviation. Simultaneously, the control module reads from its storage unit the recorded resistance adjustment value actually applied and the final pressure stability value achieved in the previous complete operating lever reciprocating cycle. The correlation information between the effects is used, and the ratio of the pressure stabilization effect value to the resistance adjustment value in this correlation information is used as a historical correction factor for fine-tuning the resistance. This historical correction factor is an algebraic value. Then, based on the current operation stage of the control lever and the difference amplitude, the corresponding resistance adjustment base value is determined through a preset fuzzy control lookup table. This can be achieved in the following way: based on the operation duration, the established negative pressure level, and the statistical characteristics of the pressure characteristic value, it is determined whether the current stage is a rapid pressure building period with the main goal of quickly establishing negative pressure, or a fine pressure stabilization period with the main goal of finely maintaining pressure stability. The identified current operation stage and the calculated difference amplitude are used as inputs to query a preset fuzzy control lookup table. The lookup table predefines the basic resistance adjustment value to be output when the difference amplitude belongs to different fuzzy levels (small, medium, and large) at different operation stages. A basic resistance adjustment value corresponding to the current state combination is directly obtained by looking up the table. Finally, the resistance adjustment value of the operating lever in the current operation stage can be determined by the historical correction factor and the basic resistance adjustment value in the following way: the historical correction factor is used to compensate for systematic deviations caused by mechanical wear, temperature changes, or individual operating habits, so that the adjustment has adaptability; the resistance adjustment base value obtained from the fuzzy control lookup table is added to the historical correction factor, and the result of the addition operation is the resistance adjustment value of the operating lever in the current operation stage.

[0038] In some embodiments, adjusting the motion resistance of the manual operating lever based on the resistance adjustment value to obtain the tactile feedback characteristics of the manual operating lever to the operator can be achieved through the following steps: The resistance adjustment value is converted into a control signal, which drives the magnetorheological damper integrated at the operating lever shaft to change the current intensity of the internal magnetic field, thereby adjusting the damping force of the operating lever movement. By controlling the damping force to undergo step changes and pulse fluctuations within a specified time period, the tactile feedback characteristics of the manual control lever to the operator can be obtained.

[0039] It should be noted that, in this application, the control signal is used to convert the digital resistance adjustment command into an analog electrical signal that represents the change in physical damping force; the magnetorheological damper is an electromechanical actuator used to adjust its output damping force in real time and steplessly by changing the input current, thereby providing variable motion resistance for the manual operating lever; the damping force is the mechanical resistance used to impede the movement of the manual operating lever; and the tactile feedback feature is a tactile signal pattern formed by the programmed damping force change pattern.

[0040] In specific implementation, firstly, the resistance adjustment value is converted into a control signal to drive the magnetorheological damper integrated at the operating lever shaft to change the current intensity of the internal magnetic field, thereby adjusting the damping force of the operating lever movement. This can be achieved in the following way: the control module converts the resistance adjustment value into an electrical signal. This module contains a digital-to-analog converter unit, which converts the resistance adjustment value, as a digital quantity, into a corresponding DC current analog signal according to a preset ratio. This DC current analog signal is output as a control signal and transmitted to the magnetorheological damper integrated at the mechanical shaft or hinge point of the manual operating lever. The magnetorheological damper is encapsulated with magnetorheological fluid, whose rheological properties (viscosity) change rapidly with the change of the applied magnetic field strength. The current intensity flowing into the coil inside the magnetorheological damper determines the magnetic field strength, thereby continuously changing the viscosity of the magnetorheological fluid, which manifests as a change in the magnitude of the damping force resisting the rotation of the operating lever. In this way, the real-time adjustment of the damping force of the operating lever movement can be achieved; then, by controlling the resistance... The damping force undergoes step changes and pulse fluctuations within a specified time period, thus generating tactile feedback characteristics of the manual control lever for the operator. This can be achieved in the following ways: At a preset specified time point or when a specified trigger condition is met (e.g., when the pressure characteristic value exceeds the allowable upper limit and a serious leakage warning needs to be issued), the control module dynamically modulates the output control signal according to a predetermined program, instructing the control signal to change from one current value to another higher current value within a specified time (e.g., 100 milliseconds), thereby causing a significant instantaneous increase in damping force, which the operator will perceive as a clear jolt; or, the control module instructs the control signal to periodically switch on and off at a specified frequency and duty cycle, forming a pulse sequence, thereby causing high-frequency, small-amplitude periodic fluctuations in damping force, which the operator will perceive as a tremor. By predefining different damping force change patterns, tactile feedback characteristics of the manual control lever for the operator with specific meanings, which can be distinguished by the operator's touch, can be generated.

[0041] In step 104, during the dosing process of the main drug bag, the actual pressure of the drug bag is compensated by the tactile feedback feature to maintain the current pressure value inside the main drug bag within the negative pressure threshold range.

[0042] In some embodiments, the following steps can be used to compensate for the actual pressure of the medicine bag through the tactile feedback feature and maintain the current pressure value inside the main medicine bag within the negative pressure threshold range: After the operator perceives the tactile feedback features, they determine the current system status according to the pre-trained operating procedures and perform corresponding compensatory manual operations. When the operator adjusts the manual operation, the negative pressure convergence characteristics of the current pressure value inside the main drug bag relative to the negative pressure threshold range are determined by the pressure change information collected in real time. The actual pressure of the medicine bag is compensated based on the negative pressure convergence characteristic to maintain the current pressure value inside the main medicine bag within the negative pressure threshold range.

[0043] It should be noted that, in this application, compensatory manual operation is a manual action used to correct the current operating state and bring it back to the normal target range; negative pressure convergence characteristic is a judgment index used to describe the dynamic trend and efficiency of the current pressure value inside the main drug bag returning to the target negative pressure threshold range after the compensation operation is applied; auxiliary compensation is an automatic control function that is automatically triggered by precision electromechanical components to finely adjust the pressure inside the main drug bag when the operator's manual compensation effect is insufficient.

[0044] In specific implementation, firstly, after the operator perceives the tactile feedback feature, according to the pre-trained operating procedures, the current system state is determined, and corresponding compensatory manual operations are performed. This can be achieved in the following way: During the reciprocating operation of the manual lever, the operator perceives tactile feedback features formed by a specified damping force change pattern (e.g., a noticeable "jerkiness"). Based on the pre-trained operating procedures, the operator interprets this tactile feature as corresponding state information (e.g., "jerkiness" corresponds to "suspected leak, need to check and slow down the operation"). Based on this judgment, the operator immediately performs the compensatory manual operations specified in the training, such as immediately pausing the operation and checking the sealing of the drug bag and pipeline, or changing to a slower, smaller-amplitude reciprocating motion in subsequent operations. Then, when the operator adjusts the manual operation, the negative pressure convergence feature of the current pressure value inside the main drug bag relative to the negative pressure threshold range is determined by real-time collected pressure change information. This can be achieved in the following way: During the operator's performance of the compensatory manual operation, the control module continuously collects real-time pressure change information inside the main drug bag through the pressure sensor. The system collects information and calculates the current pressure value in real time. By continuously comparing the current pressure value with the upper and lower limits of the negative pressure threshold range, the control module determines whether the pressure value is returning to the range or deviating further, and calculates the rate of return. The judgment results regarding the pressure return trend and rate are used as the negative pressure convergence characteristics of the current pressure value inside the main drug bag relative to the negative pressure threshold range. Finally, based on the negative pressure convergence characteristics, auxiliary compensation is performed on the actual pressure of the drug bag to maintain the current pressure value inside the main drug bag within the negative pressure threshold range. This can be achieved in the following way: In other words, if the negative pressure convergence characteristics indicate that the operator's compensatory manual operation alone cannot effectively pull the pressure back and stabilize it within the negative pressure threshold range within the preset time window (e.g., 5 seconds), the control module will automatically activate the auxiliary compensation mechanism. This auxiliary compensation mechanism includes: briefly opening a miniature normally closed solenoid valve connected in parallel to the medicine bag for slight pressure relief, or instantaneously starting a backup miniature electric negative pressure pump for supplementary pumping; and assisting manual operation by executing automatic adjustment actions to ultimately maintain and stabilize the current pressure value inside the main medicine bag within the preset negative pressure threshold range.

[0045] In another aspect, in some embodiments, this application provides a portable negative pressure drug delivery device for high-altitude medical use, as referenced. Figure 3 The figure is a schematic diagram of the structure of a portable negative pressure dosing device for high-altitude medical use, according to some embodiments of this application. The portable negative pressure dosing device for high-altitude medical use includes: a data acquisition module 201, a processing module 202, and an execution module 203, which are described below: The acquisition module 201 in this application is mainly used to collect pressure change information inside the main medicine bag when the operator repeatedly moves the manual operating lever to establish the expected negative pressure, and then extract the pressure characteristic value inside the main medicine bag from the pressure change information. Processing module 202, in this application, is used to determine the high-altitude low-pressure compensation coefficient in the main medicine bag based on the altitude value and absolute atmospheric pressure of the device environment, and to determine the negative pressure threshold range of the main medicine bag under negative pressure by the high-altitude low-pressure compensation coefficient and the target volume of the main medicine bag. It should be noted that the processing module 202 is also used to determine the resistance adjustment value of the operating lever in the current operation stage based on the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold range when the pressure characteristic value is greater than the upper limit of the negative pressure threshold range, and to adjust the motion resistance of the manual operating lever based on the resistance adjustment value, thereby obtaining the tactile feedback characteristics of the manual operating lever to the operator. The execution module 203 in this application is mainly used to provide feedback compensation for the actual pressure of the main drug bag through the tactile feedback feature during the drug addition process, so as to maintain the current pressure value inside the main drug bag within the negative pressure threshold range.

[0046] The foregoing has detailed examples of portable negative pressure drug delivery devices and methods for high-altitude medical use provided in the embodiments of this application. It is understood that, in order to achieve the aforementioned functions, the corresponding devices include hardware structures and / or software modules for executing each function. Those skilled in the art should readily recognize that, based on the units and algorithm steps of the examples described in conjunction with the embodiments disclosed herein, this application can be implemented in hardware or a combination of hardware and computer software. Whether a function is executed in hardware or by computer software driving hardware depends on the specific application and design constraints of the technical solution. Those skilled in the art can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of this application.

[0047] In some embodiments, this application also provides a computer device, the computer device including a memory and a processor, the memory for storing a computer program, and the processor for calling and running the computer program from the memory, so that the computer device performs the above-described portable negative pressure drug delivery method for high-altitude medical use.

[0048] In some embodiments, reference Figure 4The dashed lines in the figure indicate that the unit or module is optional. This figure is a schematic diagram of the structure of a computer device for implementing a portable negative pressure drug delivery method for high-altitude medical use, according to an embodiment of this application. The portable negative pressure drug delivery method for high-altitude medical use described in the above embodiments can be achieved through… Figure 4 The computer device shown is used to implement this, and the computer device includes at least one processor 301, a memory 302 and at least one communication unit 305. The computer device may be a terminal device, a server or a chip.

[0049] Processor 301 can be a general-purpose processor or a special-purpose processor. For example, processor 301 can be a central processing unit (CPU), which can be used to control computer devices, execute software programs, and process data from software programs. The computer device may also include a communication unit 305 for inputting (receiving) and outputting (transmitting) signals.

[0050] For example, the computer device may be a chip, and the communication unit 305 may be the input and / or output circuit of the chip, or the communication unit 305 may be the communication interface of the chip, which may be a component of a terminal device, network device or other device.

[0051] For example, the computer device may be a terminal device or a server, and the communication unit 305 may be a transceiver of the terminal device or the server, or the communication unit 305 may be a transceiver circuit of the terminal device or the server.

[0052] The computer device may include one or more memories 302 storing a program 304. The program 304 can be executed by a processor 301 to generate instructions 303, causing the processor 301 to execute the method described in the above method embodiments according to the instructions 303. Optionally, the memory 302 may also store data (such as a target audit model). Optionally, the processor 301 may also read data stored in the memory 302, which may be stored at the same storage address as the program 304, or it may be stored at a different storage address than the program 304.

[0053] The processor 301 and memory 302 can be configured separately or integrated together, for example, integrated on the system on chip (SOC) of the terminal device.

[0054] It should be understood that each step of the above method embodiment can be completed by hardware logic circuits or software instructions in the processor 301. The processor 301 can be a CPU, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or other programmable logic devices, such as discrete gates, transistor logic devices, or discrete hardware components.

[0055] Those skilled in the art will understand that embodiments of this application can be provided as methods, systems, or computer program products. Therefore, this application can take the form of a completely hardware embodiment, a completely software embodiment, or an embodiment combining software and hardware aspects. Furthermore, this application can take the form of a computer program product embodied on one or more computer-usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer-usable program code.

[0056] For example, in some embodiments, this application also provides a computer-readable storage medium storing instructions or code that, when executed on a computer, cause the computer to implement the above-described portable negative pressure drug delivery method for high-altitude medical use.

[0057] Although preferred embodiments of this application have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of this application.

[0058] Obviously, those skilled in the art can make various modifications and variations to this application without departing from the spirit and scope of this application. Therefore, if such modifications and variations fall within the scope of the claims of this application and their equivalents, this application also intends to include such modifications and variations.

Claims

1. A portable negative pressure drug delivery method for high-altitude medical use, characterized in that, Includes the following steps: When the operator repeatedly moves the manual control lever to establish the expected negative pressure, the pressure change information inside the main drug bag is collected, and then the pressure characteristic value inside the main drug bag is extracted from the pressure change information. The high-altitude low-pressure compensation coefficient in the main drug solution bag is determined based on the altitude and absolute atmospheric pressure of the device environment. The negative pressure threshold range of the main drug solution bag under negative pressure is determined by the high-altitude low-pressure compensation coefficient and the target volume of the main drug solution bag. When the pressure characteristic value is greater than the upper limit of the negative pressure threshold in the negative pressure threshold range, the resistance adjustment value of the operating lever in the current operation stage is determined according to the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold. Based on the resistance adjustment value, the motion resistance of the manual operating lever is adjusted to obtain the tactile feedback characteristics of the manual operating lever to the operator. During the dosing process of the main drug solution bag, the actual pressure of the drug solution bag is compensated by the tactile feedback feature to maintain the current pressure value inside the main drug solution bag within the negative pressure threshold range.

2. The method as described in claim 1, characterized in that, Extracting the pressure characteristic value inside the main drug solution bag from the pressure change information specifically includes: The pressure change information is filtered by a moving average to obtain a filtered pressure sequence. Based on the filtered pressure sequence, the pressure change within each sampling period is calculated. The pressure characteristic value inside the main drug solution bag is determined based on all pressure changes.

3. The method as described in claim 1, characterized in that, The high-altitude low-pressure compensation coefficient for the main drug solution bag is determined based on the altitude and absolute atmospheric pressure of the device environment. Specifically, this includes: The device obtains the real-time absolute air pressure by integrating a barometric pressure sensor and obtains the current altitude value by manual input, thereby obtaining the relative air pressure ratio of the device environment; The real-time temperature of the environment in which the device is located is obtained using a temperature sensor, and a temperature correction coefficient is obtained based on the atmospheric temperature-altitude model of the plateau region. The high-altitude low-pressure compensation coefficient inside the medicine bag is determined based on the relative air pressure ratio and the temperature correction coefficient.

4. The method as described in claim 1, characterized in that, The determination of the negative pressure threshold range for the main drug solution bag under negative pressure establishment, based on the high-altitude low-pressure compensation coefficient and the target volume of the main drug solution bag, specifically includes: Based on the target volume of the main drug solution bag, the basic negative pressure range under standard conditions is obtained from a preset lookup table; The base pressure range is linearly scaled using the plateau low-pressure compensation coefficient to obtain the target negative pressure range under plateau conditions. Based on the dynamic tolerance band of the main drug solution bag, the tolerance of the target negative pressure range is expanded to obtain the negative pressure threshold range established by the main drug solution bag under negative pressure.

5. The method as described in claim 1, characterized in that, Determining the resistance adjustment value of the operating lever in the current operating phase based on the difference between the pressure characteristic value and the upper limit of the negative pressure threshold specifically includes: Determine the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold, and obtain the historical correction factor of the resistance adjustment effect feedback in the previous operation cycle; Based on the current operating stage of the control lever and the difference amplitude, the corresponding basic resistance adjustment value is determined through a preset fuzzy control lookup table; The resistance adjustment value of the operating lever in the current operating phase is determined by the historical correction factor and the resistance adjustment base value.

6. The method as described in claim 1, characterized in that, Based on the aforementioned resistance adjustment value, the motion resistance of the manual operating lever is adjusted in feedback, thereby obtaining the tactile feedback characteristics of the manual operating lever to the operator, specifically including: The resistance adjustment value is converted into a control signal, which drives the magnetorheological damper integrated at the operating lever shaft to change the current intensity of the internal magnetic field, thereby adjusting the damping force of the operating lever movement. By controlling the damping force to undergo step changes and pulse fluctuations within a specified time period, the tactile feedback characteristics of the manual control lever to the operator can be obtained.

7. The method as described in claim 1, characterized in that, The tactile feedback feature provides feedback compensation for the actual pressure of the medicine bag, maintaining the current pressure value inside the main medicine bag within the negative pressure threshold range. Specifically, this includes: After the operator perceives the tactile feedback features, they determine the current system status according to the pre-trained operating procedures and perform corresponding compensatory manual operations. When the operator adjusts the manual operation, the negative pressure convergence characteristics of the current pressure value inside the main drug bag relative to the negative pressure threshold range are determined by the pressure change information collected in real time. The actual pressure of the medicine bag is compensated based on the negative pressure convergence characteristic to maintain the current pressure value inside the main medicine bag within the negative pressure threshold range.

8. A portable negative pressure drug delivery device for high-altitude medical use, characterized in that, include: The acquisition module is used to collect pressure change information inside the main drug bag when the operator repeatedly pulls the manual control lever to establish the expected negative pressure, and then extract the pressure characteristic value inside the main drug bag from the pressure change information. The processing module is used to determine the high-altitude low-pressure compensation coefficient in the main medicine bag based on the altitude and absolute atmospheric pressure of the device environment, and to determine the negative pressure threshold range of the main medicine bag under negative pressure by using the high-altitude low-pressure compensation coefficient and the target volume of the main medicine bag. The processing module is further configured to determine the resistance adjustment value of the operating lever in the current operation stage based on the difference amplitude between the pressure characteristic value and the upper limit of the negative pressure threshold range when the pressure characteristic value is greater than the upper limit of the negative pressure threshold range, and to adjust the motion resistance of the manual operating lever based on the resistance adjustment value, thereby obtaining the tactile feedback characteristics of the manual operating lever to the operator. The execution module is used to provide feedback compensation for the actual pressure of the main drug solution bag during the drug addition process through the tactile feedback feature, so as to maintain the current pressure value inside the main drug solution bag within the negative pressure threshold range.

9. A computer device, characterized in that, The computer device includes a memory and a processor. The memory is used to store computer programs, and the processor is used to call and run the computer programs from the memory, so that the computer device performs the portable negative pressure drug delivery method for high-altitude medical use as described in any one of claims 1 to 7.

10. A computer-readable storage medium, characterized in that, The computer-readable storage medium stores instructions or code that, when executed on a computer, cause the computer to perform the portable negative pressure drug delivery method for high-altitude medical use as described in any one of claims 1 to 7.

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