Systems and methods for multi-channel vases

By embedding 3D tissue structures into microphysiological devices, vascular interfaces with natural biological characteristics are formed, solving the problem of insufficient perfusion efficiency in multi-organ networks and realizing efficient culture and functional simulation of multi-organ networks.

CN122081065APending Publication Date: 2026-05-26THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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Patent Information

Application Number
CN202610221230.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2018-03-26
Filing Date
2019-03-26
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing organ-on-a-chip devices cannot create functional and/or realistic multi-organ networks, cannot generalize complex physiological responses and multi-organ interactions at the system level, and have insufficient perfusion efficiency, which limits the growth and development of 3D tissues.

Method used

By embedding tissues in a 3D structure within a microphysiological device, a vascular interface with the characteristics of a natural biological target tissue is formed. Vascular growth factors such as HIF, FGF, and VEGF are used to regulate vascular properties such as density, diameter, and barrier function, thus forming a multi-channel vascular culture system.

Benefits of technology

It achieves efficient perfusion of multi-organ networks, promotes tissue development, survival and homeostasis, simulates the human vascular system, and supports in vitro studies of tissue function and drug screening.

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Abstract

Systems and methods for a multi-channel vessel and multi-organ vessel-vessel fluid interface in an in vitro model are disclosed. The method comprises: embedding at least one tissue in a 3D structure; forming a vascular interface for perfusion of nutrients into the one or more tissues; adjusting the one or more vascular interfaces together or separately by altering vascular properties to possess characteristics of the natural biological target tissue or target environment; and lining the fluid interface channel to provide growth fluid in a physiologically summarized manner. The 3D structure includes vasculature elements for vasculature regeneration or vasculature generation.
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